CN105968109B - 一种制备帕博西尼中间体的方法 - Google Patents
一种制备帕博西尼中间体的方法 Download PDFInfo
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- CN105968109B CN105968109B CN201610320997.8A CN201610320997A CN105968109B CN 105968109 B CN105968109 B CN 105968109B CN 201610320997 A CN201610320997 A CN 201610320997A CN 105968109 B CN105968109 B CN 105968109B
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- pyrimidine
- methyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201610320997.8A CN105968109B (zh) | 2016-05-13 | 2016-05-13 | 一种制备帕博西尼中间体的方法 |
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CN201610320997.8A CN105968109B (zh) | 2016-05-13 | 2016-05-13 | 一种制备帕博西尼中间体的方法 |
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CN105968109A CN105968109A (zh) | 2016-09-28 |
CN105968109B true CN105968109B (zh) | 2017-11-17 |
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CN201610320997.8A Expired - Fee Related CN105968109B (zh) | 2016-05-13 | 2016-05-13 | 一种制备帕博西尼中间体的方法 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN106565707B (zh) * | 2016-11-03 | 2019-01-04 | 杭州科巢生物科技有限公司 | 帕博西尼新合成方法 |
CN106970177B (zh) * | 2017-06-06 | 2018-05-15 | 北京元延医药科技股份有限公司 | 帕博西尼中间体及其杂质的分析检测方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104892604A (zh) * | 2015-06-19 | 2015-09-09 | 北京康立生医药技术开发有限公司 | 一种新型的cdk4抑制剂的合成方法 |
CN105294681A (zh) * | 2014-07-26 | 2016-02-03 | 广东东阳光药业有限公司 | Cdk类小分子抑制剂的化合物及其用途 |
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US20020025968A1 (en) * | 1998-04-15 | 2002-02-28 | Rifat Pamukcu | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives |
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Patent Citations (2)
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CN105294681A (zh) * | 2014-07-26 | 2016-02-03 | 广东东阳光药业有限公司 | Cdk类小分子抑制剂的化合物及其用途 |
CN104892604A (zh) * | 2015-06-19 | 2015-09-09 | 北京康立生医药技术开发有限公司 | 一种新型的cdk4抑制剂的合成方法 |
Non-Patent Citations (1)
Title |
---|
Design, Synthesis, and Evaluation in Vitro of Quinoline-8-carboxamides, a New Class of Poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) Inhibitor;Anna-Marie Lord et al.;《J. Med. Chem.》;20081231;第52卷(第3期);868-877 * |
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CN105968109A (zh) | 2016-09-28 |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Nie Hongmei Inventor after: Li Jianai Inventor after: Yu Mingxia Inventor before: Wang Chuanxiu |
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CB03 | Change of inventor or designer information | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20171024 Address after: 276399 No. 2, unit 14, building 70, building 401, Yuquanlu Road, Linyi, Shandong, Yinan Applicant after: Nie Hongmei Applicant after: Li Jianai Applicant after: Yu Mingxia Address before: 266109 Shandong, Qingdao, Chengyang District, No. 825 Zhengyang Road, building, room 1, office, room 205 Applicant before: The skies, Qingdao Bioisystech Co., Ltd |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171117 Termination date: 20180513 |
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CF01 | Termination of patent right due to non-payment of annual fee |