CN105963469A - Traditional Chinese herbal medicine composition for treating haemorrhoids and postoperative complications thereof - Google Patents
Traditional Chinese herbal medicine composition for treating haemorrhoids and postoperative complications thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese herbal medicine composition for treating haemorrhoids and postoperative complications thereof, and relates to medicinal preparations containing herbs. The composition is prepared from the following traditional Chinese herbal medicinal materials in parts by weight: 1-100 parts of haematococcaceae, 5-25 parts of cynanchum glaucescens, 10-30 parts of rosa cymosa, 10-40 parts of Chinese fevervine herb and root, 10-50 parts of Chinese yam, 5-15 parts of belamcanda sinensis, 5-15 parts of cucumber, 1-3 parts of silver and 5-15 parts of fructus evodiae. The traditional Chinese herbal medicine composition can be used for effectively treating haemorrhoid diseases, and has a positive effect for recovery after haemorrhoidectomy, and has remarkable curative effect, no toxic or side effect and no drug dependence. Compared with the prior art, the traditional Chinese herbal medicine composition has the advantages of higher safety, no allergy, long-term human body application availability and low cost, has a high application value, and is suitable for popularization and application.
Description
Technical field
The present invention relates to a kind of medicinal preparation containing plant, particularly relate to one and treat hemorrhoid and post-operative complication thereof
Herbal composite.
Background technology
Hemorrhoid are a kind of commonly encountered diseases, frequently-occurring diseases, the most just have saying of " ten people nine hemorrhoid ", and hemorrhoid are that anus pad pathologic hypertrophy moves
The agglomerate that position and crissum veins beneath the skin clump stasis of blood stream are formed.Main clinical manifestation for having blood in stool, pain, edema, falling inflation, pruritus,
The symptom such as secretions increase and abjection, relevant research shows, the sickness rate of China's hemorrhoid is about 46%, many in some district
Reach 70%.There is having blood in stool because of hemorrhoid in many patients, deviate from and the symptom such as pain, have had a strong impact on life, working and learning,
So there being the exploitation of the hemorrhoid treating medicine of good result to have great importance.
The method for the treatment of hemorrhoid mainly has Drug therapy, surgical ligation and injection treatment at present.Anorectal educational circles of China 2000
April in year has held national hemorrhoid disease symposium in Chengdu, explicitly points out " the purpose of all treatments in the new definition of hemorrhoid
Not being to eliminate hemorrhoid body, but eliminate symptom, the symptom releasing hemorrhoid is more more meaningful than changing hemorrhoid body size, should be considered treatment effect
The standard of fruit ".These new treatment concept make the Therapeutic Principle of hemorrhoid clearly, and non-operative treatment especially basic pharmaceutical is treated
Importance appeared suddenly.Now mostly the suggestion of scholar be the therapeutic purposes of hemorrhoid be to eliminate symptom, asymptomatic hemorrhoid are without controlling
Treating, Symptomatic hemorrhoid more than 90% can eliminate symptom through non-operative treatment, and the hemorrhoid patients only less than 10% needs surgery to control
Treat.Drug therapy energy reducing swelling and alleviating pain, relief of symptoms, turn avoid the pain of operation and the complication of injection treatment, so absolutely
Most people is suitable for using Drug therapy.Drug therapy occupies critical role in the treatment of hemorrhoid, and Chinese medicine preparation is due to curative effect
Notable and low toxic and side effects, extensively by expert and the favorable comment of patient.The Chinese medicine preparation treating hemorrhoid on market has ointment, suppository, patch
Agent, ointment, lotion, oral formulations etc., manufacturer is the most numerous.The hemorrhoid class ointment of controlling sold on domestic market mainly has
MAYINGLONG MUSK HEMORRHOID UNGUENTUM, Gangtai Ointment, hemorrhoid-eliminating paste, jiuhua plaster, bear's gall ointment etc..These medicines have heat-clearing and toxic substances removing more,
The effect such as reducing swelling and alleviating pain, removing the necrotic tissue and promoting granulation, but have that anti-inflammatory analgesic effect is undesirable and the deficiency such as drug dependence.
Summary of the invention
It is an object of the invention to the defect overcoming prior art to exist, it is provided that one can effectively treat hemorrhoid and postoperative
The herbal composite of complication.
Treatment hemorrhoid of the present invention and the herbal composite of post-operative complication thereof, by following portions by weight
Medical herbs forms:
Haematococcus Pluvialis 1～100, Rhizoma Cynanchi Stauntonii 5～25, Smallfruit Rose Root 10～30, Herba Paederiae 10～40, Rhizoma Dioscoreae 10～50, crow fan 5
～15, Viola grypoceras A. Gray 5～15, silver 1～3, Wu Lai cornel 5～15.
Preferably herbal composite is made up of the Chinese herbal medicine of following portions by weight:
Haematococcus Pluvialis 15～75, Rhizoma Cynanchi Stauntonii 15～20, Smallfruit Rose Root 20～25, Herba Paederiae 15～30, Rhizoma Dioscoreae 20～40, crow fan
10～15, Viola grypoceras A. Gray 10～15, silver 2～3, Wu Lai cornel 10～15.
Preferred herbal composite is made up of the Chinese herbal medicine of following portions by weight:
Haematococcus Pluvialis 45～65, Rhizoma Cynanchi Stauntonii 18～20, Smallfruit Rose Root 22～25, Herba Paederiae 20～25, Rhizoma Dioscoreae 25～30, crow fan
13～15, Viola grypoceras A. Gray 13～15, silver 2～3, Wu Lai cornel 13～15.
Most preferably herbal composite is made up of the Chinese herbal medicine of following portions by weight:
Haematococcus Pluvialis 55, Rhizoma Cynanchi Stauntonii 18, Smallfruit Rose Root 23, Herba Paederiae 23, Rhizoma Dioscoreae 25, crow fan 14, Viola grypoceras A. Gray 14, silver 2,
Wu Lai cornel 13～14.
The preparation method of a kind of herbal composite treating hemorrhoid and post-operative complication thereof, comprises the following steps:
(1) prepare each raw material the most dried, weigh each raw material by weight, standby；
(2) raw material weighed in step (1) mixing being inserted in decoction still, add deionized water, big fire decocts 30-45min,
Slow fire boiling 2-3h again, filters decocting liquid, collects filtrate, is concentrated into ointment shape.
Preferably, described herbal composite is external preparation, can be any in gel, ointment or ointment
A kind of.
The present invention provide treatment hemorrhoid and the herbal composite of post-operative complication, compared with prior art have with
Lower effect: Traditional Chinese medicine composition formula of the present invention is scientific and reasonable, it is possible to effectively treat hemorrhoids disease, simultaneously to hemorrhoid post-operative recovery
Having positive effect, curative effect is obvious, there is not any toxic and side effects, does not also have drug dependence, compared to prior art
Safer, do not have allergy, be suitable for human body life-time service, and with low cost, therefore, the present invention has the highest application valency
Value, is suitable to popularization and application.
Detailed description of the invention
Embodiment one
1, prepare Haematococcus Pluvialis 3g, Rhizoma Cynanchi Stauntonii 5g, Smallfruit Rose Root 12g, Herba Paederiae 12g, Rhizoma Dioscoreae 7g, crow fan 6g, Viola grypoceras A. Gray 6g,
Silver 13g, Wu Lai cornel 7g.
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, filters decocting liquid, collects filtrate, be concentrated into ointment shape.
Embodiment two
1, Haematococcus Pluvialis 90g, Rhizoma Cynanchi Stauntonii 23g, Smallfruit Rose Root 28g, Herba Paederiae 37g, Rhizoma Dioscoreae 38g, crow fan 13g, Viola grypoceras A. Gray are prepared
13g, silver 3g, Wu Lai cornel 13g.
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, filters decocting liquid, collects filtrate, be concentrated into ointment shape.
Embodiment three
1, Haematococcus Pluvialis 15g, Rhizoma Cynanchi Stauntonii 17g, Smallfruit Rose Root 20g, Herba Paederiae 15g, Rhizoma Dioscoreae 24g, crow fan 11g, Radix Rehmanniae are prepared
Melon 11g, silver 2g, Wu Lai cornel 11g.
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, filters decocting liquid, collects filtrate, be concentrated into ointment shape.
Embodiment four
1, Haematococcus Pluvialis 75g, Rhizoma Cynanchi Stauntonii 20g, Smallfruit Rose Root 25g, Herba Paederiae 30g, Rhizoma Dioscoreae 40g, crow fan 15g, Radix Rehmanniae are prepared
Melon 15g, silver 3g, Wu Lai cornel 15 g.
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, filters decocting liquid, collects filtrate, be concentrated into ointment shape.
Embodiment five
1, Haematococcus Pluvialis 45g, Rhizoma Cynanchi Stauntonii 18g, Smallfruit Rose Root 22g, Herba Paederiae 20g, Rhizoma Dioscoreae 25g, crow fan 13g, Radix Rehmanniae are prepared
Melon 13g, silver 2g, Wu Lai cornel 13g.
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, filters decocting liquid, collects filtrate, be concentrated into ointment shape.
Embodiment six
1, Haematococcus Pluvialis 65g, Rhizoma Cynanchi Stauntonii 20g, Smallfruit Rose Root 25g, Herba Paederiae 25g, Rhizoma Dioscoreae 30g, crow fan 15g, Radix Rehmanniae are prepared
Melon 15g, silver 3g, Wu Lai cornel 15 g.
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, filters decocting liquid, collects filtrate, be concentrated into ointment shape.
Embodiment seven
1, Haematococcus Pluvialis 55g, Rhizoma Cynanchi Stauntonii 18g, Smallfruit Rose Root 23g, Herba Paederiae 23g, Rhizoma Dioscoreae 25g, crow fan 14g, Viola grypoceras A. Gray are prepared
14g, silver 2g, Wu Lai cornel 13～14.
2, clean up and dried each raw material above-mentioned, then above-mentioned raw materials mixing is inserted in decoction still, add
Deionized water, big fire decocts 30-45min, then slow fire boiling 2-3h, filters decocting liquid, collects filtrate, be concentrated into ointment shape.
Embodiment eight
The herbal composite experiment to rat Oleum Tiglii hemorrhoid model
50 SD rats (about 200 grams) are randomly divided into five groups by body weight, i.e. low group of model control group, herbal composite
Group (dosage is 1000mg/kg), herbal composite in (dosage is 100mg/kg), herbal composite
High group of (dosage is 10g/kg), Ma Yinglong group, often group 10.It is administered: rat carries a few days ago drop rectum with drug, often
It secondary, is stained with medicine with 10mg cotton balls, cotton balls is filled in internal rectum, when next time is administered, should first check whether internal rectum has cotton
Ball (should take out if any cotton balls).Last administration should after modeling 2 hours.
Modeling: Oleum Tiglii is a kind of conventional proinflammatory agent, conventional Oleum Tiglii mixed liquor 1 part of distilled water, 4 parts of pyrroles
Pyridine, 5 parts of ether and 10 part of 15% Oleum Tiglii diethyl ether solution preparation.It is stained with Oleum Tiglii mixed liquor with 10mg cotton balls, will leaching
Cotton balls after bubble puts into rat anal, takes out after stopping 15 seconds.
Index determining: after modeling 7 hours, her Wen orchid normal saline solution (2ml/ of every rat intravenous injection 1%
Kg), sacrificed by exsanguination animal after 40 minutes, cut-off intestinal and perianal tissue, with acetone normal saline 7: 3 solution after weighing
Soaking 48 hours, 3000rpm is centrifuged 10 minutes, takes supernatant and surveys absorbance in 590nm, as evaluating vascular permeability
Property index, the results are shown in Table 1.
Table 1 each treatment group and the comparison of model control group absorbance
* compare with model control group, * P ＜ 0.05, * * P ＜ 0.01
Result shows, the rectum vein that herbal composite of the present invention can well reduce Oleum Tiglii hemorrhoid model mice is penetrating
Property, in compositions, various Chinese medicinal components achieve good synergism, from reality in terms for the treatment of rat Oleum Tiglii hemorrhoid model
Testing in data visible, a certain proportion of compositions curative effect is better than Ma Yinglong randomized controlled treatment group.
The mice dimethylbenzene antiinflammatory experiment of embodiment nine herbal composite
60 KM mices, male and female half and half, body weight 25-30 gram, it is randomly divided into five groups by body weight, i.e. model control group, Chinese herbal medicine group
Group (dosage is 1000mg/kg), medium-height grass in low group of compound (dosage is 100mg/kg), herbal composite
Drug composition high group (dosage is 10g/kg), Ma Yinglong group, often group 12.
Experimental technique:
Take dimethylbenzene 20 μ l, be applied to each mouse right ear.Take after 30min and be respectively the most uniformly applied to mouse right ear, auris dextra by reagent
Putting to death to after dimethylbenzene 3.5h, and measure the ear method of double differences, assay method is: cuts two ears at auricle baseline, beats with 8mm
Hole device lays auricle at the same position of left and right ear, weighs, the ear method of double differences=auris dextra tablet weight-left auricle weight, the results are shown in Table 2.
Table 2 each experimental group ear method of double differences compares
Compare with matched group, * P ＜ 0.05, * * P ＜ 0.01.
Conclusion: herbal composite compositions of the present invention has obvious antiinflammatory action, the antiinflammatory effect of herbal composite high group
Fruit is better than Ma Yinglong group.
Mice analgesic activity is tested by embodiment ten herbal composite of the present invention
KM mice 60, male and female half and half, body weight 25-30 gram, it is randomly divided into four groups by body weight, i.e. model control group, Chinese herbal medicine group
Group (dosage is 1000mg/kg), medium-height grass in low group of compound (dosage is 100mg/kg), herbal composite
Drug composition high group (dosage is 10g/kg), Ma Yinglong group, often group 12.Mice anum administration, cotton with 10mg
Ball is stained with medicine, and cotton balls is filled in internal rectum, once a day, continuous three days, after last administration 30 minutes, away from
At anus 3.5cm, rectal wall injects 5% formalin 0.2ml.Record mice writhing number of times in 20 minutes.Concrete outcome
It is shown in Table 3.
Table 3 each experimental group writhing number of times compares
Compare with matched group, * P ＜ 0.05, * * P ＜ 0.01.
Conclusion: in this is tested, herbal composite has significant analgesic activities, herbal composite high group
Analgesic effect be better than Ma Yinglong group.
Embodiment 11 herbal composite of the present invention clinical efficacy
Clinical trial uses parallel control, random, Double-blind double-dummy, multiple center trial method for designing, observes medium-height grass of the present invention
Drug composition treatment inflammatory external hemorrhoid and hemorrhoid postoperative caused anus swelling, the clinical efficacy of pain and safety thereof.
Clinic observes case 520 example altogether.II phase inflammatory external hemorrhoid case 130 example, III phase inflammatory external hemorrhoid case 180
Example, hemorrhoid postoperative case 200 example.The course for the treatment of is 7 days.
(1) II clinical trial phase inflammatory external hemorrhoid result of the test:
Clinical cure rate to inflammatory external hemorrhoid is 31.88%, and obvious effective rate is 48.06%, and cure-remarkable-effectiveness rate is 79.94%；
Clinical cure rate to patient's anus swelling is 62.19%, and obvious effective rate is 17.42%, and cure-remarkable-effectiveness rate is 79.61%；
Clinical cure rate to patient's proctalgia is 78.94%, and obvious effective rate is 6.88%, and cure-remarkable-effectiveness rate is 85.82%；
(2) III clinical trial phase inflammatory external hemorrhoid result of the test:
Clinical cure rate to inflammatory external hemorrhoid is 53.70%, and obvious effective rate is 39.70%, and cure-remarkable-effectiveness rate is 93.40%；
Clinical cure rate to patient's anus swelling is 84.30%, and obvious effective rate is 6.90%, and cure-remarkable-effectiveness rate is 91.20%；
Clinical cure rate to patient's proctalgia is 93.50%, and obvious effective rate is 4.20%, and cure-remarkable-effectiveness rate is 97.70%；
Detumescence average onset time to anus swelling is 2.77 days, and the pain relieving average onset time to proctalgia is 2.27
My god.
(3) the postoperative result of the test of hemorrhoid:
Clinical cure rate to patient's anus swelling is 86.10%, and obvious effective rate is 8.40%, and cure-remarkable-effectiveness rate is 94.50%；
Clinical cure rate to patient's proctalgia is 87.70%, and obvious effective rate is 7.90%, and cure-remarkable-effectiveness rate is 95.60%；
Detumescence average onset time to anus swelling is 2.87 days, and the pain relieving average onset time to proctalgia is 2.11
My god, the detumescence uniform release time to anus swelling is 5.32 days, and the pain relieving uniform release time to proctalgia is 4.77
My god.
(4) safety of clinical trials result
Participate in clinical trial case before the test after all carried out blood, urine, stool routine examination, hepatic and renal function, Electrocardioscopy, not
Find the abnormal change relevant with trial drug, process of the test has no adverse events.
Claims (4)
1. treatment hemorrhoid and the herbal composite of post-operative complication thereof, it is characterised in that by the Chinese herbal medicine group of following portions by weight
Become: Haematococcus Pluvialis 1～100, Rhizoma Cynanchi Stauntonii 5～25, Smallfruit Rose Root 10～30, Herba Paederiae 10～40, Rhizoma Dioscoreae 10～50, crow fan 5
～15, Viola grypoceras A. Gray 5～15, silver 1～3, Wu Lai cornel 5～15.
2. treatment hemorrhoid as claimed in claim 1 and the herbal composite of post-operative complication thereof, it is characterised in that by following
Parts by weight Chinese herbal medicine composition: Haematococcus Pluvialis 15～75, Rhizoma Cynanchi Stauntonii 15～20, Smallfruit Rose Root 20～25, Herba Paederiae 15～30,
Rhizoma Dioscoreae 20～40, crow fan 10～15, Viola grypoceras A. Gray 10～15, silver 2～3, Wu Lai cornel 10～15.
3. treatment hemorrhoid as claimed in claim 2 and the herbal composite of post-operative complication thereof, it is characterised in that by following
Parts by weight Chinese herbal medicine composition: Haematococcus Pluvialis 45～65, Rhizoma Cynanchi Stauntonii 18～20, Smallfruit Rose Root 22～25, Herba Paederiae 20～25,
Rhizoma Dioscoreae 25～30, crow fan 13～15, Viola grypoceras A. Gray 13～15, silver 2～3, Wu Lai cornel 13～15.
4. treatment hemorrhoid as claimed in claim 3 and the herbal composite of post-operative complication thereof, it is characterised in that by following
Parts by weight Chinese herbal medicine composition: Haematococcus Pluvialis 55, Rhizoma Cynanchi Stauntonii 18, Smallfruit Rose Root 23, Herba Paederiae 23, Rhizoma Dioscoreae 25, crow fan 14,
Viola grypoceras A. Gray 14, silver 2, Wu Lai cornel 13～14.
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Non-Patent Citations (2)
| Title |
|---|
| 丁丽菊，等: "痔疮中药治疗的实验和临床研究进展", 《亚太传统医药》 * |
| 杨卫平: "《新编中草药彩色图谱与验方》", 30 April 2004, 江西科学技术出版社 * |
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Application publication date: 20160928 |