CN105943953A - Health product for treating diabetes and preparation method thereof - Google Patents

Health product for treating diabetes and preparation method thereof Download PDF

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Publication number
CN105943953A
CN105943953A CN201610497348.5A CN201610497348A CN105943953A CN 105943953 A CN105943953 A CN 105943953A CN 201610497348 A CN201610497348 A CN 201610497348A CN 105943953 A CN105943953 A CN 105943953A
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parts
extract
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dried
health product
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傅志勇
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61K36/06—Fungi, e.g. yeasts
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention provides a health product for treating diabetes and a preparation method thereof. The health product can be used for treating diabetes and has the advantages of little side effects and high cure rate. The health product comprises the following raw materials in parts by weight: 20 to 30 parts of a wheat grass extract, 15 to 25 parts of konjac glycan, 5 to 10 parts of se-enriched yeast, 15 to 20 parts of buckwheat, 13 to 17 parts of a walnut seed powder, 15 to 20 parts of bitter gourds, 10 to 15 parts of inulin, 20 to 30 parts of Chinese yam, 10 to 15 parts of dark plums, 9 to 17 parts of longan, 5 to 25 parts of coix seeds, 8 to 20 parts of pumpkin, 15 to 30 parts of black soya beans, 20 to 30 parts of lophatherum gracile and 5 to 10 parts of a mulberry leaf extract. According to the method, raw materials with different physicochemical properties can be treated differently, and finally evenly mixed, and the effective components of all the raw materials can be retained furthest, synergistically play the pesticide role, ensure mutual gains, and all together play the role of curing diabetes.

Description

A kind of health product treating diabetes and preparation method thereof
Technical field
The invention belongs to health care of food product technical field, be specifically related to a kind of health product treating diabetes and Preparation method.
Background technology
Diabetes be by inherited genetic factors, immunologic function disorder, microorganism infection and toxin thereof, free radical toxin, The various virulence factor of Nervous and Mental Factors etc. acts on body and causes hypoinsulinism, insulin resistant etc. to draw A series of metabolism disorder syndromes such as sugar, protein, fat, water and the electrolyte sent out, clinically with high blood Sugar is main feature, and model case may occur in which polyuria, polydipsia, polyphagia, the performance such as become thin, i.e. three-many-one-little Symptom.
Diabetes may result in infection, heart change, cerebrovascular disease, renal failure, lose the sight of both eyes, under Limb gangrene etc. and become the lethal main cause disabled.Diabetes height oozes the serious acute that syndrome is diabetes Complication, the starting stage can behave as polyuria, polydipsia, fatigue and weakness, bradykinesia etc., along with body loses The increase state of an illness of the water yield drastically develops, and the similar brains such as drowsiness, disorientation, epileptic are twitched, hemiplegia occurs The symptom of apoplexy, even goes into a coma.
The most still lack the specific drug for the treatment of diabetes.The drug main depressor to be included of western medical treatment diabetes Thing and insulin, antihypertensive drugs includes sulphanylureas, biguanides, prandial glucose regulator etc., pharmacologically, Antihypertensive drugs such as angiotensin converting enzyme inhibitor or Angiotensin Ⅱ receptor antagonist are often drug of first choice Thing, often needs to combine other depressor such as calcium antagonist, diuretic, beta-blocker etc., although above this A little antihypertensive drugs have certain curative effect to the treatment of diabetes, but its effect is not it is obvious that have in clinic A little antihypertensive drugs also have toxic and side effects to patient, and side effect as the most serious in biguanides is to cause breast Acidosis, after generation, mortality rate is 50%, unsuitable long-term taking.
In recent years, use pharmaceutical composition that the treatment of diabetes is achieved certain effect.In recent years, greatly Amount relates to treating the pharmaceutical composition application of diabetes Chinese patent.Such as, publication number 00122950.8 " one Kind of medicine treating diabetes and preparation method thereof ", publication number 02124998.9 " a kind of diabetes for the treatment of Medicated tea and preparation method ", application number 200710300014.5 is " for treating Chinese patent medicine and the life thereof of diabetes Production. art " and application number 200910226792.3 " a kind of ultra micron Chinese medicinal blood glucose reducing treating diabetes " etc.. These pharmaceutical compositions no doubt have certain curative effect, but curative effect is definite not simultaneously, and cure rate is relatively low.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of health care treating diabetes Product and preparation method thereof.Diabetes can effectively be treated by described health product, have that side effect is little, cure rate is high Advantage.
The technical solution adopted in the present invention is:
A kind of health product treating diabetes, including the raw material of following weight portion: Caulis et Folium Tritici aestivi extract 20-30 Part, Rhizoma amorphophalli polysaccharide 15-25 part, yeast rich in selenium 5-10 part, Fagopyrum esculentum Moench powder 15-20 part, Semen Juglandis powder 13-17 Part, Fructus Momordicae charantiae 15-20 part, inulin 10-15 part, Rhizoma Dioscoreae 20-30 part, Fructus Mume 10-15 part, Arillus Longan 9-17 Part, Semen Coicis 5-25 part, Fructus Cucurbitae moschatae 8-20 part, Semen sojae atricolor 15-30 part, Herba Lophatheri 20-30 part and Folium Mori extract Thing 5-10 part.
In order to the curative effect making described health product is more definite, preferred technical scheme is, described health product include The raw material of following weight portion: Caulis et Folium Tritici aestivi extract 25 parts, Rhizoma amorphophalli polysaccharide 20 parts, yeast rich in selenium 7 parts, buckwheat Flour 17 parts, Semen Juglandis powder 15 parts, 17 parts of Fructus Momordicae charantiae, inulin 12 parts, Rhizoma Dioscoreae 25 parts, Fructus Mume 12 parts, Arillus Longan 13 parts, Semen Coicis 15 parts, 14 parts of Fructus Cucurbitae moschatae, 22 parts of Semen sojae atricolor, Herba Lophatheri 25 parts and Folium Mori extract 7 parts.
Present invention also offers the preparation method of a kind of above-mentioned health product, comprise the steps:
A, weigh Fructus Mume, Arillus Longan and Herba Lophatheri, be dried respectively, after pulverization process, after being sufficiently mixed Add water distillation, extracts volatile oil, and after extracting volatile oil, remaining medicinal residues and the another device of aqueous solution are collected；
B, weigh Fructus Momordicae charantiae and Fructus Cucurbitae moschatae is dried respectively, after pulverization process, add together with the medicinal residues in step A Soak by water obtains decoction liquor；
C, described aqueous solution and described decoction liquor are filtered respectively after merge mix homogeneously, concentrate and be spray-dried, Obtain premixing flour I；
D, weigh Caulis et Folium Tritici aestivi, be dried, after pulverization process, carry out alcohol extraction operation: add 200-400 weight Measure the ethanol of part and 40-80 DEG C of reflux, extract, 1-2h, after reclaiming ethanol, obtain alcohol extract；Described alcohol extraction operates It is repeated twice, and alcohol extract merges, more described alcohol extract is filtered successively and is spray-dried, contained Water yield Caulis et Folium Tritici aestivi extract below 5%；Weigh Folium Mori, be dried, after pulverization process, carry out alcohol extraction Operation: add the ethanol of 200-400 weight portion and 40-80 DEG C of reflux, extract, 1-2h, obtain after reclaiming ethanol Alcohol extract；Described alcohol extraction operation is repeated twice, and alcohol extract merges, then is carried out successively by described alcohol extract Filter and spray drying, obtain water content Folium Mori extract below 5%；By described Caulis et Folium Tritici aestivi extract and Mulberry Leaf extract mix homogeneously, obtains premixing flour II；
E, weigh Rhizoma Dioscoreae, Semen Coicis and Semen sojae atricolor, after being dried respectively, grind to form micropowder, obtain ultra-fine Premixing flour；
F, will the premixing flour I that obtain in the volatile oil that obtain in step A, step C, step D obtain Premixing flour II and ultra-fine premixing flour mix homogeneously, be sequentially added into Rhizoma amorphophalli polysaccharide, yeast rich in selenium, Fagopyrum esculentum Moench powder, Semen Juglandis powder and inulin mix homogeneously, obtain described health product.
In step A, after pulverizing, 100-150 mesh sieve crossed by medicated powder pulverization process obtained.
Decoction in step B operates to be divided into three times and carries out, and decoct concretely comprises the following steps every time: use raw material weight Measure the water of 6-8 times, raw material is decocted, after being heated to boiling and keeping 1-3 hour, take solution；Three times After decoction completes, the solution of acquirement is merged.
The temperature of the concentration operation in step C is 70-90 DEG C.
In step D, 20-100 mesh sieve will be crossed after Caulis et Folium Tritici aestivi and Folium Mori drying and crushing；The volume integral of described ethanol Number is 85-95%.
In step E, the temperature of drying process is 110-130 DEG C, and drying time is 0.5-1.5h.
In step F, by the premixing flour I obtained in the volatile oil obtained in step A, step C, step D In cross 100-200 mesh sieve after the premixing flour II that obtains and ultra-fine premixing flour mix homogeneously.
For the ease of understanding the present invention, below the raw material in the present invention and drug effect are further elaborated.
Caulis et Folium Tritici aestivi extract, is the nutritional labeling extracted from Caulis et Folium Tritici aestivi (Wheatgrass), in Caulis et Folium Tritici aestivi Containing abundant chlorophyll, aminoacid, vitamin, mineral and ferment, have anticancer, the liver protecting, Strengthen the health-care effect such as cell viability, blood sugar lowering.In the present invention, the preparation method of Caulis et Folium Tritici aestivi extract is: claim Take Caulis et Folium Tritici aestivi, be dried, after pulverization process, after being sufficiently mixed, carry out alcohol extraction operation: use ethanol and 40-80 DEG C of reflux, extract, 1-2h, obtains alcohol extract after reclaiming ethanol；Described alcohol extraction operation is repeated twice, and alcohol Extract merges, then is filtered successively by described alcohol extract and be spray-dried, and obtains water content below 5% Caulis et Folium Tritici aestivi extract.
Rhizoma amorphophalli polysaccharide, also known as konjacmannan, English name: Konjac flour, it is possible to be effectively reduced gallbladder Sterin, blood glucose and fat-reducing, will have wide practical use in pharmaceuticals industry, can be used for treating hyperlipidemia, sugar Urine disease, obesity and constipation etc..
Yeast rich in selenium, Classification system: Selenium enriched yeast, add during culture yeasts Selenium element, has absorbed selenium during yeast growth, make selenium protein in yeast body and polysaccharide organic be combined It is converted into biological selenium, thus eliminates chemistry selenium (such as sodium selenite) and toxicity and the intestines and stomach of human body are stung Swash, enable that selenium is more efficient, be more safely absorbed by the body utilization.Yeast rich in selenium is also the most domestic The most efficiently, the selenium-replenishing preparation that the safest, nutrition equalizes most.
Fagopyrum esculentum Moench powder, the powder worn into for Semen Fagopyri Esculenti (Fagopyrum esculentum Moench.), Semen Fagopyri Esculenti sugariness Cool, there is a wide intestinal of appetizing, therapeutic method to keep the adverse QI flowing downwards removing food stagnancy, control dry cholera, the intestines and stomach stagnates, effect of chronic diarrhea.
Semen Juglandis powder, the powder worn into for Semen Juglandis, Semen Juglandis has the kidney invigorating warming the lung, effect of loosening bowel to relieve constipation.
Fructus Momordicae charantiae, Classification system: Momordica charantia L., there is heat-clearing and toxic substances removing, skin care skin care, fall blood Sugar, liver nourishing of nourishing blood, heat-clearing and toxic substances removing, effect of improving eyesight.
Inulin, Classification system: Inulin, Synanthrin, CAS accession number 9005-80-5；Inulin is plant Middle deposit polysaccharide, is mainly derived from plant, has and controls blood fat, reduction blood glucose, the suction of promotion mineral Receipts, regulating intestinal canal microorganism species, improve intestinal health and prevent effect of constipation.
Rhizoma Dioscoreae, has nourishing strong, aid digestion, holds back sweating due to debility, and effect of antidiarrheal cures mainly insufficiency of the spleen diarrhoea, lung Empty cough, diabetes are quenched one's thirst, oliguria frequency, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.
Fructus Mume, near ripe for being dried of rose department plant plum (Prunus mume (Sieb.) Sieb.etZuce.) Fruit, has and astringes the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, effect of relieving colic caused by ascaris；It is usually used in chronic cough of deficiency lung, chronic diarrhea chronic dysentery, void Heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache.
Arillus Longan, Classification system: Dimocarpus longan Lour., there is reinforcing the heart spleen, replenishing QI and blood, strengthening the spleen and stomach, Support effect of muscle；For worry impairing spleen, dizzy, insomnia, severe palpitation, empty win, after being ill or body in puerperal Void, and owing to insufficiency of the spleen caused hematochezia is lost blood disease.
Semen Coicis, for grass Semen Coicis Coix lacryma-jobi L.var.mayuen. (Roman.) Stapf Dry mature kernal, there is promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, eliminating impediment, evacuation of pus, effect of detoxicating and resolving stagnation of pathogens； For edema, tinea pedis, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis, cancerous protuberance, wart.
Fructus Cucurbitae moschatae, Classification system: Cucurbita moschata (Duch.ex Lam.) Duch.ex Poiret, have Invigorating the spleen and replenishing QI, blood fat reducing, blood sugar lowering, heat-clearing and toxic substances removing, protection gastric mucosa and digestive effect.
Semen sojae atricolor, for the black seeds of legume soybean (Glycinemax (L.) merr), its sweet in the mouth, property Flat, nontoxic；There are heat clearing away of inducing sweat, the suppressing the hyperactive liver that nourishes blood, Bu Shen Zhuang the moon, effect of qi-restoratives hair color.
Herba Lophatheri, Classification system: Lophatherum gracile, have refrigerant, antipyretic, diuresis and hastening parturition Effect；Cure mainly in the heart disease heat, cough with dyspnea, haematemesis, pyretic toxicity wind, only quench one's thirst, press borax poison, expectorant, control Fanatical unhappiness, apoplectic aphasia are in silence, wind syndrome of head, spasmolytic are throbbed with fear bitterly, pestilence fan is vexed, kill small worm, heat extraction delays spleen.
Folium Mori extract, be from Folium Mori (Morus alba L.) extract nutritional labeling, Folium Mori have have thin Dissipate wind heat, clearing away lung-heat and moistening for dryness, effect of liver heat removing and eyesight improving, can treat anemopyretic cold, lung-heat type cough, dizziness headache, The disease that conjunctival congestion is dim-sighted, in the present invention, the preparation method of Folium Mori extract is: weigh Folium Mori, be dried, After pulverization process, carry out alcohol extraction operation after being sufficiently mixed: use ethanol and 40-80 DEG C of reflux, extract, 1-2h, Alcohol extract is obtained after reclaiming ethanol；Described alcohol extraction operation is repeated twice, and alcohol extract merges, then by described alcohol Extract filters successively and is spray-dried, and obtains water content Folium Mori extract below 5%.
The invention have the benefit that
1, the invention provides one and treat health-care product for curing diabetes, use multiple natural food as raw material, its In；Caulis et Folium Tritici aestivi extract, Rhizoma amorphophalli polysaccharide have the effect protecting the liver blood sugar lowering, be aided with Fagopyrum esculentum Moench powder, Semen Juglandis powder, Yeast rich in selenium, Rhizoma Dioscoreae, Arillus Longan, the therapeutic method to keep the adverse QI flowing downwards removing food stagnancy of Semen sojae atricolor, the effect of the kidney invigorating warming the lung, add Fructus Momordicae charantiae, inulin, Fructus Cucurbitae moschatae, Herba Lophatheri and Folium Mori extract control blood fat, drop hypoglycemic effect, Fructus Mume, the promoting the production of body fluid of Semen Coicis The effect of spleen invigorating, above-mentioned all raw materials coordination compatibility, mutual gain, jointly play effect for the treatment of diabetes, There is the advantage that side effect is little, cure rate is high.
2, the described preparation method in the present invention, by with Fructus Mume, Arillus Longan and Herba Lophatheri as raw material, steaming Evaporate extraction operation；With Fructus Momordicae charantiae and Fructus Cucurbitae moschatae as raw material, boiling；With Caulis et Folium Tritici aestivi and Folium Mori as raw material, pulverize Rear alcohol extraction, and Rhizoma Dioscoreae, Semen Coicis and Semen sojae atricolor are ground to form micropowder, the raw material of different physicochemical properties is done not With processing, final mix homogeneously, the effective ingredient of various raw materials is able to maximum reservation, and drug effect is worked in coordination with to be sent out Wave, mutual gain, jointly play effect for the treatment of diabetes.
Detailed description of the invention
Below in conjunction with embodiment, further illustrate present disclosure.Should be appreciated that the enforcement of the present invention Being not limited to the following examples, any pro forma accommodation and/or the change of being made the present invention all will fall Enter scope.
In the present invention, if not refering in particular to, all of part, percentage ratio are unit of weight, all of equipment and Raw materials etc. are all commercially available or the industry is conventional.Method in following embodiment, as without saying especially Bright, it is the conventional method of this area.In the present invention, the particle size of described micropowder is less than 10 μm.
Embodiment 1
A kind of health product treating diabetes, including the raw material of following weight: Caulis et Folium Tritici aestivi extract 20g, evil spirit Taro polysaccharide 25g, yeast rich in selenium 5g, Fagopyrum esculentum Moench powder 20g, Semen Juglandis powder 13g, Fructus Momordicae charantiae 20g, inulin 10g, Rhizoma Dioscoreae 30g, Fructus Mume 10g, Arillus Longan 17g, Semen Coicis 5g, Fructus Cucurbitae moschatae 20g, Semen sojae atricolor 15g, Herba Lophatheri 30g With Folium Mori extract 5g.
The preparation method of described health product, comprises the steps:
A, weigh Fructus Mume, Arillus Longan and Herba Lophatheri, be dried respectively, pulverization process, pulverization process is obtained To medicated powder cross 100 mesh sieves, after sieving, medicated powder is sufficiently mixed the distillation that adds water, extracts volatile oil, extraction is waved After hair oil, remaining medicinal residues and the another device of aqueous solution are collected；
B, weigh Fructus Momordicae charantiae and Fructus Cucurbitae moschatae is dried respectively, after pulverization process, add together with the medicinal residues in step A Soak by water obtains decoction liquor；Decocting operation to be divided into three times and carrying out, decoct concretely comprises the following steps every time: use raw material The water that weight is 8 times, decocts raw material, after being heated to boiling and keeping 1 hour, takes solution；Three times After decoction completes, the solution of acquirement is merged；
C, described aqueous solution and described decoction liquor are filtered respectively after merge mix homogeneously, at 90 DEG C concentrate And be spray-dried, obtain premixing flour I；
D, weigh Caulis et Folium Tritici aestivi, be dried, cross 20 mesh sieves after pulverization process, then carry out alcohol extraction operation: Addition 400g volume fraction is the ethanol of 85% and obtains alcohol extraction after 80 DEG C of reflux, extract, 1h, recovery ethanol Liquid；Described alcohol extraction operation be repeated twice, and alcohol extract merge, then by described alcohol extract successively carry out filter and It is spray-dried, obtains water content Caulis et Folium Tritici aestivi extract below 5%；Weigh Folium Mori, be dried, pulverize Cross 100 mesh sieves after process, then carry out alcohol extraction operation: add ethanol that 200g volume fraction is 95% and 40 DEG C of reflux, extract, 2h, obtain alcohol extract after reclaiming ethanol；Described alcohol extraction operation is repeated twice, and alcohol extract Merge, more described alcohol extract is filtered successively and is spray-dried, obtain water content Folium Mori below 5% Extract；By described Caulis et Folium Tritici aestivi extract and Folium Mori extract mix homogeneously, obtain premixing flour II；
E, weigh Rhizoma Dioscoreae, Semen Coicis and Semen sojae atricolor, after being dried respectively, grind to form micropowder, obtain ultra-fine Premixing flour；The temperature of drying process is 110 DEG C, and drying time is 1.5h；
F, will the premixing flour I that obtain in the volatile oil that obtain in step A, step C, step D obtain Premixing flour II and ultra-fine premixing flour mix homogeneously after cross 100 mesh sieves, be sequentially added into Rhizoma amorphophalli polysaccharide, selenium-rich ferment Mother, Fagopyrum esculentum Moench powder, Semen Juglandis powder and inulin mix homogeneously, obtain described health product.
Embodiment 2
A kind of health product treating diabetes, including the raw material of following weight: Caulis et Folium Tritici aestivi extract 30g, evil spirit Taro polysaccharide 15g, yeast rich in selenium 10g, Fagopyrum esculentum Moench powder 15g, Semen Juglandis powder 17g, Fructus Momordicae charantiae 15g, inulin 15g, Rhizoma Dioscoreae 20g, Fructus Mume 15g, Arillus Longan 9g, Semen Coicis 25g, Fructus Cucurbitae moschatae 8g, Semen sojae atricolor 30g, Herba Lophatheri 20g and Folium Mori extract 10g.
The preparation method of described health product, comprises the steps:
A, weigh Fructus Mume, Arillus Longan and Herba Lophatheri, be dried respectively, pulverization process, pulverization process is obtained To medicated powder cross 150 mesh sieves, after sieving, medicated powder is sufficiently mixed the distillation that adds water, extracts volatile oil, extraction is waved After hair oil, remaining medicinal residues and the another device of aqueous solution are collected；
B, weigh Fructus Momordicae charantiae and Fructus Cucurbitae moschatae is dried respectively, after pulverization process, add together with the medicinal residues in step A Soak by water obtains decoction liquor；Decocting operation to be divided into three times and carrying out, decoct concretely comprises the following steps every time: use raw material The water that weight is 6 times, decocts raw material, after being heated to boiling and keeping 3 hours, takes solution；Three times After decoction completes, the solution of acquirement is merged；
C, described aqueous solution and described decoction liquor are filtered respectively after merge mix homogeneously, at 70 DEG C concentrate And be spray-dried, obtain premixing flour I；
D, weigh Caulis et Folium Tritici aestivi, be dried, cross 100 mesh sieves after pulverization process, then carry out alcohol extraction operation: Addition 200g volume fraction is the ethanol of 95% and obtains alcohol extraction after 40 DEG C of reflux, extract, 2h, recovery ethanol Liquid；Described alcohol extraction operation be repeated twice, and alcohol extract merge, then by described alcohol extract successively carry out filter and It is spray-dried, obtains water content Caulis et Folium Tritici aestivi extract below 5%；Weigh Folium Mori, be dried, pulverize Cross 20 mesh sieves after process, then carry out alcohol extraction operation: add ethanol that 400g volume fraction is 85% and 80 DEG C of reflux, extract, 1h, obtain alcohol extract after reclaiming ethanol；Described alcohol extraction operation is repeated twice, and alcohol extract Merge, more described alcohol extract is filtered successively and is spray-dried, obtain water content Folium Mori below 5% Extract；By described Caulis et Folium Tritici aestivi extract and Folium Mori extract mix homogeneously, obtain premixing flour II；
E, weigh Rhizoma Dioscoreae, Semen Coicis and Semen sojae atricolor, after being dried respectively, grind to form micropowder, obtain ultra-fine Premixing flour；The temperature of drying process is 130 DEG C, and drying time is 0.5h；
F, will the premixing flour I that obtain in the volatile oil that obtain in step A, step C, step D obtain Premixing flour II and ultra-fine premixing flour mix homogeneously after cross 200 mesh sieves, be sequentially added into Rhizoma amorphophalli polysaccharide, selenium-rich ferment Mother, Fagopyrum esculentum Moench powder, Semen Juglandis powder and inulin mix homogeneously, obtain described health product.
Embodiment 3
A kind of health product treating diabetes, including the raw material of following weight: Caulis et Folium Tritici aestivi extract 25g, evil spirit Taro polysaccharide 20g, yeast rich in selenium 7g, Fagopyrum esculentum Moench powder 17g, Semen Juglandis powder 15g, Fructus Momordicae charantiae 17g, inulin 12g, Rhizoma Dioscoreae 25g, Fructus Mume 12g, Arillus Longan 13g, Semen Coicis 15g, Fructus Cucurbitae moschatae 14g, Semen sojae atricolor 22g, Herba Lophatheri 25g With Folium Mori extract 7g.
The preparation method of described health product, comprises the steps:
A, weigh Fructus Mume, Arillus Longan and Herba Lophatheri, be dried respectively, pulverization process, pulverization process is obtained To medicated powder cross 120 mesh sieves, after sieving, medicated powder is sufficiently mixed the distillation that adds water, extracts volatile oil, extraction is waved After hair oil, remaining medicinal residues and the another device of aqueous solution are collected；
B, weigh Fructus Momordicae charantiae and Fructus Cucurbitae moschatae is dried respectively, after pulverization process, add together with the medicinal residues in step A Soak by water obtains decoction liquor；Decocting operation to be divided into three times and carrying out, decoct concretely comprises the following steps every time: use raw material The water that weight is 7 times, decocts raw material, after being heated to boiling and keeping 2 hours, takes solution；Three times After decoction completes, the solution of acquirement is merged；
C, described aqueous solution and described decoction liquor are filtered respectively after merge mix homogeneously, at 80 DEG C concentrate And be spray-dried, obtain premixing flour I；
D, weigh Caulis et Folium Tritici aestivi, be dried, cross 60 mesh sieves after pulverization process, then carry out alcohol extraction operation: Addition 300g volume fraction is the ethanol of 90% and obtains alcohol after 60 DEG C of reflux, extract, 1.5h, recovery ethanol Extract；Described alcohol extraction operation is repeated twice, and alcohol extract merges, then is filtered successively by described alcohol extract And spray drying, obtain water content Caulis et Folium Tritici aestivi extract below 5%；Weigh Folium Mori, be dried, powder Cross 60 mesh sieves after broken process, then carry out alcohol extraction operation: add ethanol that 300g volume fraction is 90% also 60 DEG C of reflux, extract, 1.5h, after reclaiming ethanol, obtain alcohol extract；Described alcohol extraction operation is repeated twice, and alcohol Extract merges, then is filtered successively by described alcohol extract and be spray-dried, and obtains water content below 5% Folium Mori extract；By described Caulis et Folium Tritici aestivi extract and Folium Mori extract mix homogeneously, obtain premixing flour II；
E, weigh Rhizoma Dioscoreae, Semen Coicis and Semen sojae atricolor, after being dried respectively, grind to form micropowder, obtain ultra-fine Premixing flour；The temperature of drying process is 120 DEG C, and drying time is 1h；
F, will the premixing flour I that obtain in the volatile oil that obtain in step A, step C, step D obtain Premixing flour II and ultra-fine premixing flour mix homogeneously after cross 150 mesh sieves, be sequentially added into Rhizoma amorphophalli polysaccharide, selenium-rich ferment Mother, Fagopyrum esculentum Moench powder, Semen Juglandis powder and inulin mix homogeneously, obtain described health product.
Experimental example
The therapeutic test below done for a kind of pharmaceutical composition treating diabetes in the present invention:
(1), testing crew physical data
Select various diabetes 400 example made a definite diagnosis through hospital, type i diabetes and type ii diabetes difference 200 People, the wherein multiple teenager of being born in of type i diabetes, onset is anxious, and symptom is obvious and heavy, can be with in ketosis acid Poison is onset symptoms；Type ii diabetes is more common in more than 40 years old adult and old people, is mostly soft-fat type, Onset is slow, and symptom is lighter.Overall patient's age is 26～66 years old and in normal distribution, the mean age 46 Year.
(2), diagnostic criteria
Meet the WHO diagnostic criteria (1996) about diabetes, fasting glucose >=7.0 mM/l Or OGTT2 hour >=11.1 mM/ls.
Comprehensively comment with reference to whole nation diabetes meeting index relevant with blood circulation promoting and blood stasis dispelling meeting and efficacy assessment standard Fixed, except Diabetic Acute complication and the heart, Liver and kidney function exhaustion, infect and merge other endocrine disease Sick.The diabetic symptom weight loss of polydipsia, polyuria and unknown cause (classical symptom include) is plus following Anticipate one: random time plasma glucose levels >=11.1 mM/l (200 milligram/deciliter) or empty stomach Plasma glucose (FPG) level >=7.0 mM/l (126 milligram/deciliter) or oral glucose tolerance In test (OGTT), 2 hours blood glucoses (2hPG) level >=11.1 mM/l (200 milligram/deciliter).
Non-diabetic symptom, then need the another above-mentioned blood glucose of day rechecking.
(3), test method
Patient is administered orally the pharmaceutical composition in the present invention in embodiment 3, three times a day, each 20-30g, meal Half an hour after is taken, and within three months, is a course for the treatment of, if curing in the phase course for the treatment of, discontinues medication, and a course for the treatment of unites Meter therapeutic outcome.
(4), curative effect determinate standard
Effective: symptom and sign disappear substantially, hemorheology 5, fibrinolytic system 2 are improved, Fasting glucose≤110mg/dl, twenty-four-hour urine sugar≤5g or blood glucose, glucose in urine relatively treat front drop-out value >=50% Person；
Take a turn for the better: symptom and sign substantially alleviate, hemorheology and fibrinolytic system 4 or 4 is derived above changes Kind, fasting glucose≤150mg/dl, the sugared quantitative≤10g of twenty-four-hour urine or blood glucose, glucose in urine relatively treat front decline Value >=30%；
Invalid: through treatment in 3 months, symptom was without any improvement, even has the trend increased the weight of.
Cure and take a turn for the better and all count effectively statistics.
(5), result of the test and conclusion
After statistics is taken medicine 3 months, add up therapeutic outcome.Experimental result is shown in Table 1:
Table 1: experimental result statistical table
During medication, find no any toxic and side effects, drug safety.
Conclusion: from above-mentioned therapeutic test it can be seen that the present invention provide pharmaceutical composition have instant effect, The advantage that side effect is little, cure rate is high.
Model case
1, Lee: man, 57 years old, suffers from diabetes on inspection, and fasting glucose is 12.4mmol/L, after the meal Blood glucose is 16.7mmol/L.The pharmaceutical composition taken in the present invention checked again for after 3 months, its sky of result Abdomen blood glucose is 6.4mmol/L, and post-prandial glycemia is 9.8mmol/L.
2, Zhang, man, 44 years old, suffer from diabetes on inspection, fasting glucose is 11.2mmol/L, islets of langerhans Element secretion is few, for polydipsia, polyphagia, polyuria and the classical symptom such as lose weight, and depends on islets of langerhans always Element and oral antidiabetic drug.The pharmaceutical composition taken in the present invention checked again for after 2 months, and symptom is the best Turn.After take again pharmaceutical composition in the present invention 1 month, tend to normal through measuring blood glucose, and blood so far Sugar does not rise.
3, Song, female, 39 years old.Clinical manifestation is that thirsty polydipsia, urine many, the spanomenorrhea of frequency etc. are bad Symptom, simultaneously emaciated physique, myasthenia of limbs, menolipsis, deep pulse, give up red, be hard and dry, and urine time is many, It is diagnosed as diabetes, glucose in urine through hospital.Taking the pharmaceutical composition in the present invention after 1 month, symptom is Slowing down, serve on 3 months, frequent micturition, thirsty symptom all disappear, and menstruation is risen as scheduled, and extremity are strong；Again Take 5 months, through examination in hospital, recover normal.
4, beam, man, 55 years old, suffer from diabetes on inspection, fasting glucose is 11.4mmol/L, islets of langerhans Element secretion is few, takes the pharmaceutical composition in invention the most continuously, and after 2 months, symptom is clearly better.After again Take pharmaceutical composition in the present invention continuously 3 months, tend to normal through measuring blood glucose, and blood glucose does not has so far There is rising.
5, Lu, female, 57 years old, suffer from diabetes 5 years, Symptoms is frequent micturition, polyphagia, excessive thirst, weary Power, becoming thin, fasting glucose is 11.9mmol/L；Took multi-medicament not cure, took in invention Pharmaceutical composition after 2 months symptom be obviously improved, fasting glucose is 6.7mmol/L；After taking 3 months again Diabetes are fully recovered, and fasting glucose is 5.2mmol/L；Follow up a case by regular visits to 2 years, do not recur.
It should be noted last that, above example only in order to technical scheme to be described and unrestricted, Although the present invention being described in detail with reference to preferred embodiment, be it should be understood that and be the foregoing is only The detailed description of the invention of the present invention, the protection domain being not intended to limit the present invention, all the present invention's Within spirit and principle, any modification, equivalent substitution and improvement etc. done, should be included in the present invention's Within protection domain.

Claims (9)

1. the health product treating diabetes, it is characterised in that include the raw material of following weight portion: little Wheat straw extract 20-30 part, Rhizoma amorphophalli polysaccharide 15-25 part, yeast rich in selenium 5-10 part, Fagopyrum esculentum Moench powder 15-20 part, Semen Juglandis powder 13-17 part, Fructus Momordicae charantiae 15-20 part, inulin 10-15 part, Rhizoma Dioscoreae 20-30 part, Fructus Mume 10-15 Part, Arillus Longan 9-17 part, Semen Coicis 5-25 part, Fructus Cucurbitae moschatae 8-20 part, Semen sojae atricolor 15-30 part, Herba Lophatheri 20-30 Part and Folium Mori extract 5-10 part.
Health product the most according to claim 1, it is characterised in that: include the raw material of following weight portion: Caulis et Folium Tritici aestivi extract 25 parts, Rhizoma amorphophalli polysaccharide 20 parts, yeast rich in selenium 7 parts, Fagopyrum esculentum Moench powder 17 parts, Semen Juglandis powder 15 parts, 17 parts of Fructus Momordicae charantiae, inulin 12 parts, Rhizoma Dioscoreae 25 parts, Fructus Mume 12 parts, Arillus Longan 13 parts, Semen Coicis 15 parts, 14 parts of Fructus Cucurbitae moschatae, 22 parts of Semen sojae atricolor, Herba Lophatheri 25 parts and Folium Mori extract 7 parts.
3. the preparation method of the health product described in a claim 1 or 2, it is characterised in that include as Lower step:
A, weigh Fructus Mume, Arillus Longan and Herba Lophatheri, be dried respectively, after pulverization process, after being sufficiently mixed Add water distillation, extracts volatile oil, and after extracting volatile oil, remaining medicinal residues and the another device of aqueous solution are collected；
B, weigh Fructus Momordicae charantiae and Fructus Cucurbitae moschatae is dried respectively, after pulverization process, add together with the medicinal residues in step A Soak by water obtains decoction liquor；
C, described aqueous solution and described decoction liquor are filtered respectively after merge mix homogeneously, concentrate and spray dried Dry, obtain premixing flour I；
D, weigh Caulis et Folium Tritici aestivi, be dried, after pulverization process, carry out alcohol extraction operation: add 200-400 weight Measure the ethanol of part and 40-80 DEG C of reflux, extract, 1-2h, after reclaiming ethanol, obtain alcohol extract；Described alcohol extraction operates It is repeated twice, and alcohol extract merges, more described alcohol extract is filtered successively and is spray-dried, contained Water yield Caulis et Folium Tritici aestivi extract below 5%；Weigh Folium Mori, be dried, after pulverization process, carry out alcohol extraction Operation: add the ethanol of 200-400 weight portion and 40-80 DEG C of reflux, extract, 1-2h, obtain after reclaiming ethanol Alcohol extract；Described alcohol extraction operation is repeated twice, and alcohol extract merges, then is carried out successively by described alcohol extract Filter and spray drying, obtain water content Folium Mori extract below 5%；By described Caulis et Folium Tritici aestivi extract and Mulberry Leaf extract mix homogeneously, obtains premixing flour II；
E, weigh Rhizoma Dioscoreae, Semen Coicis and Semen sojae atricolor, after being dried respectively, grind to form micropowder, obtain ultra-fine Premixing flour；
F, will the premixing flour I that obtain in the volatile oil that obtain in step A, step C, step D obtain Premixing flour II and ultra-fine premixing flour mix homogeneously, be sequentially added into Rhizoma amorphophalli polysaccharide, yeast rich in selenium, Fagopyrum esculentum Moench powder, Semen Juglandis powder and inulin mix homogeneously, obtain described health product.
Preparation method the most according to claim 3, it is characterised in that in step A, after pulverizing, 100-150 mesh sieve crossed by medicated powder pulverization process obtained.
Preparation method the most according to claim 3, it is characterised in that the decoction operation in step B Being divided into three times and carrying out, decoct concretely comprises the following steps every time: uses the water of raw material weight 6-8 times, enters raw material Row decocts, and after being heated to boiling and keeping 1-3 hour, takes solution；After three times have decocted, by obtain Solution merges.
Preparation method the most according to claim 3, it is characterised in that the concentration operation in step C Temperature be 70-90 DEG C.
Preparation method the most according to claim 3, it is characterised in that in step D, by Caulis et Folium Tritici aestivi With mistake 20-100 mesh sieve after Folium Mori drying and crushing；The volume fraction of described ethanol is 85-95%.
Preparation method the most according to claim 3, it is characterised in that in step E, drying process Temperature be 110-130 DEG C, drying time is 0.5-1.5h.
Preparation method the most according to claim 3, it is characterised in that in step F, by step A In obtain volatile oil, the premixing flour I obtained in step C, the premixing flour II obtained in step D and ultra-fine 100-200 mesh sieve is crossed after premixing flour mix homogeneously.
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CN107410861A (en) * 2017-09-15 2017-12-01 李玉保 A kind of suitable polypeptide dietotherapy rice paste of diabetic population and its preparation technology
CN107950717A (en) * 2017-12-17 2018-04-24 柳州市象行教育科技有限责任公司 A kind of health care tea capable of reducing blood sugar and preparation method thereof
CN109699897A (en) * 2019-03-07 2019-05-03 哈尔滨商业大学 A kind of food compositions preventing diabetes and its production technology

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107410861A (en) * 2017-09-15 2017-12-01 李玉保 A kind of suitable polypeptide dietotherapy rice paste of diabetic population and its preparation technology
CN107950717A (en) * 2017-12-17 2018-04-24 柳州市象行教育科技有限责任公司 A kind of health care tea capable of reducing blood sugar and preparation method thereof
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Application publication date: 20160921