CN105943901A - Traditional Chinese medicinal preparation for treating chest congestion after heart bypass - Google Patents
Traditional Chinese medicinal preparation for treating chest congestion after heart bypass Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicinal preparation for treating chest congestion after heart bypass. The traditional Chinese medicinal preparation consists of the following medicinal raw materials: raw radix astragali, body of radix angelicae sinensis, sun-cured ginseng, longan aril, rhizoma ligustici wallichii, borneol, radix notoginseng powder, cassia twig, radix salviae miltiorrhizae, radix paeoniae rubra, cortex moutan, rhizoma corydalis, fructus forsythia, honeysuckle flowers, storax, XinHui dried tangerine peel, cortex magnoliae officinalis, radix aucklandiae, raw fructus crataegi, red yeast rice, radix puerariae, root of kirilow rhodiola, folium ginkgo, scorpio, radix ophiopogonis and fruits of Chinese magnoliavine. The traditional Chinese medicinal preparation, when applied in accordance with the symptoms of qi deficiency and blood stasis, and blockade of heart vessels in patients, can take a good improving effect; the traditional Chinese medicinal preparation has therapeutic advantages which are in lack in Western medicines; and the traditional Chinese medicinal preparation is suitable for clinical popularization.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of treat heart pass after Chinese medicine preparation uncomfortable in chest.
Background technology
Bypass operation of coronary artery be exactly coronary stricture proximally and distally between set up a passage, make blood around
Cross narrow positions and arrive far-end, just as a bridge block make highway stride across mountain gully rivers unblocked.Material the most used
Material is not reinforced concrete, but the great saphenous vein of self, IMA, right gastroepiploic artery, radial artery, inferior epigastric artery etc..
Owing to artery bypass damage is big, technology requires height, and operation is more difficult to, but long-term effect is good compared with great saphenous vein, it is adaptable to
Younger patient.Generally, more than 80 years old old man great saphenous vein that can be used alone is put up a bridge, and less than 55 years old it is contemplated that entirely use tremulous pulse
Putting up a bridge, other ages can be with an IMA plus great saphenous vein.
Left main stem disease: according to guide both domestic and external, surgical operation is the first-selection of Left main stem disease.Because Left main artery is once
There is blocking or restenosis, may be fatal.In order to reduce risk, it is preferably selected bridging.
Three-image difference: lesion vessels is more, if selecting interventional therapy, will put a lot of support, and this can make restenosis, generation
The probability of thrombosis increases significantly.And, the financial burden of patient is the most heavier.
With cardiac insufficiency: this kind of patient needs complete myocardial revascularization to promote the recovery of ischemic myocardium, gets involved
It is difficult to accomplish.
Coronary heart disease myocardial infarction infectious-related complication patient: ventricular rupture, perforation of ventricular septum, mitral incompetence etc. are the most necessary
Select the treatment of surgery bypass surgery.
Owing to support needs patient to take antiplatelet drug, the patient of this drug allergy is also considered as bypass surgery.
But, if patient has the disease of respiratory system, accept general anesthesia and there may be danger, be not suitable for accepting routine in vitro circulation
Put up a bridge, and interventional therapy should be selected.
Statistics shows at present, domestic bypass surgery success rate 97%-98%.Hospitalization expenses about 5-6 ten thousand.Operation wind
There are important organ functional defect or exhaustion, acute myocardial infarction etc. in danger.
Although bypass surgery has certain risk, but uses coronary artery bypass surgery to be still in current worldwide
Treatment one of coronary stricture, the maximally effective means of myocardial ischemia.
In hospital, doctor can determine the optimal treatment hands of a kind of applicable patient symptom according to the concrete condition of patient
Section, as Drug therapy, interventional therapy or bypass surgery are treated.The advantage of interventional therapy is that wound is little, recovers fast, it is easy to by patient
Accept.But, interventional therapy has certain indication scope, and the relapse rate of angiostenosis is higher, does ordinary stent half a year
The interior patient that may have about 20% there will be the phenomenon of vascular restenosis, and uses coating stent of medicine to make vascular restenosis have
It is decreased obviously.The scope using at present interventional therapy coronary heart disease is increasingly wider, by the simplest, the Single vessel disease of limitation,
Two pathological changes treat all kinds of pathological changes etc. of coronary stricture till now.But, interventional therapy is not appropriate for all of coronary heart disease
Patient, for pathological changes than the wide and patient of Lesions in Particular Regions, takes coronary artery bypass surgery to treat than intervention
Therapeutic effect is good.Because using coronary artery bypass surgery can solve the situation of patient's coronary stricture, recurrence up hill and dale
Rate is low, and long-term effect is good.But this operation wound is bigger, and there is certain operation risk.Especially for older, both
Toward there being the people merging cerebral arteriosclerosis, cerebral infarction medical history occurring, cranial nerve complication easily occur, the lighter there will be transient
Hypomnesis, but most patient can recover normal 1 within thoughtful 7 months.And severe patient may be left over forever
Property brain injury, including stupor, hemiplegia, aphasia, serious hypomnesis, personality change etc..This situation is typically confined to part
High risk patient, incidence rate is relatively low.While it is true, it is crown to use coronary artery bypass surgery to be still current worldwide internal therapy
One of maximally effective means of stricture of artery, myocardial ischemia.
After patient's myocardial ischemia, the hemoperfusion of heart reduces, and causes the oxygen supply of heart to reduce, and energy metabolism of myocardial is the most just
Often, it is impossible to support normal heart action, after row bypass surgery, blood walks around narrow, arrives heart ischemia position, improves the heart
The blood supply of flesh, and then reach allevating angina pectoris symptom, improve cardiac function, improve patients ' life quality and prolong long-life
Purpose.But, there will be in postoperative patient a period of time uncomfortable in chest, breathe hard, cardio palmus shape, affect doctor trained in Western medicine to this disease always
Therapeutic effect and satisfaction, do not have preferable ameliorative way to this doctor trained in Western medicine, only advises patient to adjust smooth mood, minimizing motion, avoid being subject to
Cool etc., the traditional Chinese medical science is thought, patient's blood stasis due to qi deficiency, blockage of the cardiac vessels, and the traditional Chinese medical science has Coryza Treated by Syndrome Differentiation advantage, for disease for the treatment of this disease
Machine benefiting QI and nourishing blood, coronary circulation-promoting pain-relieving, improve rapidly the clinical symptoms of patient, and through clinical research and clinical observation, it is evident in efficacy,
It is applicable to clinical application invention formulation.
Summary of the invention
The technical problem to be solved is to provide a kind of Chinese medicine preparation uncomfortable in chest after treating heart pass, pin
The symptom of patient's blood stasis due to qi deficiency, blockage of the cardiac vessels is carried out verification treatment, there is good improvement result, have what Western medicine did not had
Treatment advantage, it is adaptable to clinical expansion.
For solving above-mentioned technical problem, the present invention provides a kind of Chinese medicine preparation uncomfortable in chest after treating heart pass, its raw material
Medicine includes Radix Astragali, Radix Angelicae Sinensis body, Radix Ginseng, Arillus Longan, Rhizoma Chuanxiong, Borneolum Syntheticum, Radix Notoginseng powder, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Cortex Moutan, Rhizoma Corydalis
Rope, Fructus Forsythiae, Flos Lonicerae, Styrax, Xinhui tangerine peel, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Crataegi, Monas cuspurpureus Went, Radix Puerariae, Radix Rhodiolae, Folium Ginkgo, Scorpio,
Radix Ophiopogonis and Fructus Schisandrae Chinensis.
Wherein, the weight of each crude drug of described Chinese medicine preparation be Radix Astragali 55g~65g, Radix Angelicae Sinensis body 15g~20g, Radix Ginseng
10g~20g, Arillus Longan 15g~20g, Rhizoma Chuanxiong 15g~20g, Borneolum Syntheticum 5g~10g, Radix Notoginseng powder 5g~10g, Ramulus Cinnamomi 10g~15g,
Radix Salviae Miltiorrhizae 15g~25g, Radix Paeoniae Rubra 15g~20g, Cortex Moutan 10g~20g, Rhizoma Corydalis 30g~35g, Fructus Forsythiae 15g~20g, Flos Lonicerae
10g~20g, Styrax 10g~15g, Xinhui tangerine peel 10g~15g, Cortex Magnoliae Officinalis 10g~15g, the Radix Aucklandiae 15g~20g, Fructus Crataegi 25g
~30g, Monas cuspurpureus Went 10g~15g, Radix Puerariae 30g~35g, Radix Rhodiolae 15g~20g, Folium Ginkgo 10g~15g, Scorpio 5g~8g, Mai Men
Winter 25g~35g and Fructus Schisandrae Chinensis 10g~20g.
Wherein, the weight of each crude drug of described Chinese medicine preparation be Radix Astragali 60g~65g, Radix Angelicae Sinensis body 15g~20g, Radix Ginseng
10g~15g, Arillus Longan 15g~20g, Rhizoma Chuanxiong 15g~20g, Borneolum Syntheticum 5g~8g, Radix Notoginseng powder 5g~10g, Ramulus Cinnamomi 10g~15g, pellet
Ginseng 15g~20g, Radix Paeoniae Rubra 15g~20g, Cortex Moutan 10g~15g, Rhizoma Corydalis 30g~35g, Fructus Forsythiae 15g~20g, Flos Lonicerae 15g
~20g, Styrax 10g~15g, Xinhui tangerine peel 10g~15g, Cortex Magnoliae Officinalis 10g~15g, the Radix Aucklandiae 15g~20g, Fructus Crataegi 25g~
30g, Monas cuspurpureus Went 10g~15g, Radix Puerariae 30g~35g, Radix Rhodiolae 15g~20g, Folium Ginkgo 10g~15g, Scorpio 5g~8g, Radix Ophiopogonis
30g~35g and Fructus Schisandrae Chinensis 10g~15g.
Wherein, the weight of each crude drug of described Chinese medicine preparation be Radix Astragali 60g, Radix Angelicae Sinensis body 20g, Radix Ginseng 15g, Arillus Longan
15g, Rhizoma Chuanxiong 15g, Borneolum Syntheticum 8g, Radix Notoginseng powder 5g, Ramulus Cinnamomi 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Cortex Moutan 15g, Rhizoma Corydalis 30g, Fructus Forsythiae
15g, Flos Lonicerae 15g, Styrax 10g, Xinhui tangerine peel 10g, Cortex Magnoliae Officinalis 15g, Radix Aucklandiae 20g, Fructus Crataegi 25g, Monas cuspurpureus Went 15g, Radix Puerariae
30g, Radix Rhodiolae 15g, Folium Ginkgo 10g, Scorpio 8g, Radix Ophiopogonis 30g and Fructus Schisandrae Chinensis 15g.
Wherein, described Chinese medicine preparation is prepared as oral liquid.
Present invention also offers preparation method when above-mentioned Chinese medicine preparation is prepared as oral liquid, specifically include:
The first step, takes each crude drug by above-mentioned weight, cleans respectively, pulverizes, mixes, it is thus achieved that mixture, add water
Decocting secondary, add relative to mixture quality 4~the water of 6 times for the first time, decoct 2~3 hours, second time adds relative to mixture
Quality 2~the water of 4 times, decoct 1~2 hour, collecting decoction, filters, and being concentrated into relative density is 1.05~1.10 (60 DEG C)
Clear paste, stands 24 hours, filters, decompression filtrate recycling ethanol, is dried, it is thus achieved that dry cream, and the dry cream obtained is placed on superfine powder
Broken machine is pulverized 1~2 hour, pulverizes, sieve, it is thus achieved that 300 mesh~the micropowders of 400 mesh;
Second step, takes micropowders prepared by the 500g first step, adds sucrose 50g, ethyl hydroxybenzoate 0.5g, sodium benzoate
0.3g, appropriate distilled water is heated to 30 DEG C~40 DEG C, is stirred to dissolve completely, refilters once after cold preservation 5h, and filtrate continues to add
Add distilled water adjust volume to 1000ml, stir evenly, filter, fill, sterilizing, obtain oral liquid.
Useful technique effect
The Chinese medicine preparation uncomfortable in chest after treating heart pass that the present invention provides, for patient's blood stasis due to qi deficiency, heart BI-syndrome involved the blood vessels
The symptom of resistance carries out verification treatment, has good improvement result, has the treatment advantage that Western medicine does not has, it is adaptable to clinic pushes away
Extensively.
Detailed description of the invention
The present invention provides a kind of Chinese medicine preparation uncomfortable in chest after treating heart pass, its crude drug include Radix Astragali, Radix Angelicae Sinensis body,
Radix Ginseng, Arillus Longan, Rhizoma Chuanxiong, Borneolum Syntheticum, Radix Notoginseng powder, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Cortex Moutan, Rhizoma Corydalis, Fructus Forsythiae, Flos Lonicerae, Su He
Perfume, Xinhui tangerine peel, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Crataegi, Monas cuspurpureus Went, Radix Puerariae, Radix Rhodiolae, Folium Ginkgo, Scorpio, Radix Ophiopogonis and Fructus Schisandrae Chinensis.
Syndrome of blood stasis due to qi deficiency is one of common syndrome of coronary heart disease and myocardial ischemia, and blood stasis due to qi deficiency is the card of deficiency in origin and excess in superficiality, the main blood of the heart
Arteries and veins, arteries and veins is blood mansion, with gas for this.After morbidity, carry out bypass surgery, wasting QI-blood, more increased the weight of the feelings of insufficiency of vital energy and blood
Condition, therefore occur postoperative uncomfortable in chest, breathe hard, the symptom such as weak, cyanosis.The traditional Chinese medical science thinks " qi as the commander of blood ", the most unable handsome blood of the deficiency of vital energy, blood
Stream is not smooth, and obstruction of collaterals by blood stasis forms the pathology of blood stasis due to qi deficiency.Answer giving consideration to both the incidental and fundamental when treatment, make motive foot, blood stasis dispel, then blood vessels
Logical.
Chinese medicine preparation of the present invention, according to clinical practice for many years, sums up the Chinese medicine compound of screening, has good QI invigorating
Invigorate blood circulation, effect of disperse blood stasis and dredge collateral.Side reuses Radix Astragali, coordinates the Radix Angelicae Sinensis body that dynamics of enriching blood is the strongest, combine the modern times according to ancient method
Medical practice experience, in Chinese medicine preparation of the present invention, Radix Astragali is 3:1 (or approximation 3:1) with the ratio of Radix Angelicae Sinensis body, and tangible blood is not
Energy fast-growing, invisible gas is worked as anxious solid, and therefore the Radix Astragali of invigorating the spleen and benefiting QI is reused, and Radix Angelicae Sinensis body relative quantity is little, and two medicines coordinate, in the hope of gas
Blood giving young employees remedial-courses in general knowledge and vocational skills, for monarch drug group;In addition use Radix Ginseng, Arillus Longan assist monarch drug Radix Astragali mend the whole body gas, tonifying the spleen and stomach the foundation of acquired constitution,
With metaplasia QI and blood to support congenital Liver and kidney, use Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Notoginseng powder, Rhizoma Corydalis, Radix Rhodiolae to coordinate monarch drug Radix Angelicae Sinensis body to rise and nourish blood
Invigorate blood circulation, effect of blood stasis dispelling removing heat from blood, wherein promoting flow of QI and blood is apt to by Rhizoma Chuanxiong, and Radix Paeoniae Rubra is apt to removing heat from blood and promoting blood circulation, and Radix Notoginseng powder is apt to blood circulation promoting and blood stasis dispelling, Rhizoma Corydalis
Benefaction gas promoting blood circulation and stopping pain, the angina pectoris etc. produced for myocardial ischemia has good mitigation, uses Radix Rhodiolae nourshing blood and promoting blood circulation,
Modern medicine study, Radix Rhodiolae has and improves myocardial ischemia, regulation blood fat, reduces the effect such as blood viscosity, suppression platelet aggregation, suitable
For qi stagnation and blood stasis type thoracic obstruction patient, all medicines share as ministerial drug group;After myocardial ischemia, local myocardial is downright bad, or because of bypass surgery,
The wound caused, produces the blood stasis long heat-transformation of the easy stasis of blood, therefore adds Borneolum Syntheticum, Radix Salviae Miltiorrhizae, Cortex Moutan, Fructus Forsythiae, Flos Lonicerae and aforementioned red
The medicines such as Chinese herbaceous peony, clearing away heat and cooling blood, dissolving blood stasis and detoxication, wherein Rhizoma Chuanxiong, Borneolum Syntheticum two medicine coordinate, and a temperature one is cool, and promoting flow of QI and blood does not help heat, removing heat from blood
The stasis of blood does not stay heresy, and Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Paeoniae Rubra three medicine share, and see its character, are redness, enters blood, clearing away heat and cooling blood, promoting blood circulation to remove blood stasis merit
Effect, one of Chinese medicine preparation characteristic of the present invention is to add Fructus Forsythiae, Flos Lonicerae, and two medicines share, heat-clearing and toxic substances removing, and two medicines are by entering heart channel
Gu protects heart master not by effect of heresy, modern medicine study, and two medicines are by good antiinflammatory, anti-infective effect, scorching for local
Disease has good inhibiting effect, all medicines to share as adjuvant, in addition addition Ramulus Cinnamomi warming YANG and promoting blood circulation, Fructus Trichosanthis, Bulbus Allii Macrostemonis cooperation Wen Tongxin
Arteries and veins, improves heart-yang, and effective prevention heart failure occurs, and adds Radix Puerariae regulation Taiyang channel gas, and has supplementing QI for promoting the production of body fluid effect, assistance Fructus Trichosanthis,
Bulbus Allii Macrostemonis temperature is shaken heart-yang, adds Styrax, Xinhui tangerine peel, Cortex Magnoliae Officinalis, the Radix Aucklandiae, coordinates the monarch and his subjects' Qi-tonifying drug, plays effect of circulation of qi promoting, mend and not
Stopping up, go and do not dissipate, wherein Styrax has good regulation effect to the motive, selects the famousst and precious Xinhui tangerine peel, has very
Effect of the burnt mechanism of qi of good tune three, allows the ascending, descending, exiting and entering of gas have restraining, adds Radix Ophiopogonis, Fructus Schisandrae Chinensis cooperation ministerial drug Radix Ginseng, rises
To supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid effect, Radix Ophiopogonis is cool in nature simultaneously, can help the warm-dryness syndrome of Radix Ginseng processed, and Chinese medicine preparation of the present invention is another
One characteristic is to add Fructus Crataegi, Monas cuspurpureus Went, Folium Ginkgo, and three medicines share, and has suppression serum total cholesterol and low density lipoprotein, LDL gallbladder
The rising of sterol levels, alleviates vascular endothelial cell injury, suppresses its intimal hyperplasia, improves the effects such as myocardial ischemia, onset
Rapidly, it is adaptable to angina pectoris acute attack, or be used for preventing or alleviating angina pectoris attacks, it is possible to the risk factor palliated a disease,
Can assist in Fructus Forsythiae, Flos Lonicerae preventing and treating myocardial remodelling etc., 3rd characteristic of Chinese medicine preparation of the present invention adds a small amount of Scorpio exactly, worm
Class Drug is walked to alter, and has good dredging collateral effect, for the pattern of syndrome of blood stasis due to qi deficiency after operation in patients, after adding Scorpio, and Ke Yizai
The sensible whole body of all medicines, adjusts the smooth vital organs of the human body, reaches quick-acting.
Further preferably, described Chinese medicine preparation is only prepared from by above-mentioned raw materials medicine.
Chinese medicine preparation of the present invention is prepared as oral liquid formulation, and it is right to carry out for the symptom of patient's blood stasis due to qi deficiency, blockage of the cardiac vessels
Card treatment, has good improvement result, has the treatment advantage that Western medicine does not has, it is adaptable to clinical expansion.
Each crude drug pharmacology is as follows:
Radix Astragali: latin name astragali radix, sweet in the mouth, warm in nature, enter spleen, lung meridian, have a benefit strengthening spleen and lung, rise lift yang-energy,
Strengthening superficial resistance to stop perspiration, holds in the palm the effects such as skin ulcer granulation promoting, is mainly used in the weak anorexia and loose stool that deficiency of both the splenic and pulmonary QI is caused, shortness of breath and palpitation, sinking of QI of middle-JIAO
Visceroptosis, the metrorrhagia of QI failing to control blood has blood in stool, chronic diarrhea proctoptosis;The spontaneous sweating of exterior deficiency, insufficiency of vital energy and blood etc. is demonstrate,proved.
Radix Angelicae Sinensis body: latin name Angelicae Sinensis Radix, sweet in the mouth, pungent, warm in nature, enter liver, the heart, spleen channel, have
Replenishing and activating blood, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation, cure mainly having a dizzy spell of deficiency of heart-blood, fatigue and weakness, shortness of breath and palpitation, blood
Air-sea is empty, and the cold and deficiency of CHONG and REN meridians or the menoxenia of congestion retardance, dysmenorrhoea are produced or suffer from abdominal pain, and other blood stasis are had a pain and deficiency of YIN insufficiency of blood intestinal
Dry constipation etc. are demonstrate,proved, and it can improve the blood circulation in uterus, alleviate pelvic congestion, alleviate dysmenorrhea.
Radix Ginseng: also known as Radix Ginseng, is fresh ginseng to be formed through working procedure processing such as washing, Exposure to Sunlight, drying, form keeps people
The prototype of ginseng, adds active ingredient in man-hour and volatile oil content loss is less, and the property of medicine is gentleer compared with Radix Ginseng Rubra.It can be mended greatly
Vigour: be suitable to vigour collapse, pale complexion, palpitation and restlessness, incessant sweating due to debility, has dripping cold sweat, extremity the warmest faint pulse being about to disappear person concurrently;
Invigorating the spleen to benefit the lung: spleen, insufficiency of lung-QI can be controlled.Weakness of the spleen and stomach, lassitude, vomiting are had loose bowels;Insufficiency of lung-QI, cough with asthma wind and cold weak, susceptible;
Promoting the production of body fluid to quench thirst:, fever of the body excessive thirst thirsty for Tianjin wound, sweating body is tired, rapid pulse is unable, belongs to interior-heat and deficiency of both vital energy and Yin person;Calm the nerves increasing intelligence:
Cure mainly the irritability that insufficiency of vital energy and blood causes, insomnia forgetfulness.
Arillus Longan: warm in nature, taste is sweet, has invigorating the heart and spleen, effect of nourishing blood to tranquillize the mind, for insufficiency of vital energy and blood, severe palpitation, is good for
Forget the cards such as insomnia, blood deficiency and yellow complexion.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel, there is blood-activating and qi-promoting, effect of wind-expelling pain-stopping, cure mainly menstruation not
Adjust;Amenorrhea dysmenorrhea;Puerperal the stasis of blood stagnant raw meat pain;Lump in the abdomen lump;Pain in chest and hypochondrium;Headache dizziness;Anemofrigid-damp arthralgia;Traumatic injury;Carbuncle skin ulcer
Infectionss etc. are demonstrate,proved.
Borneolum Syntheticum: acrid in the mouth, hardship, cool in nature, GUIXIN, lung meridian, there is logical all keys, dissipate stagnated fire, removing nebula improving eyesight, the merit of reducing swelling and alleviating pain
Effect, cures mainly apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, mesh also nebula
Film, enterobiasis etc. is demonstrate,proved.
Radix Notoginseng powder: latin name notoginseng radix et rhizoma, for panax araliaceae plant dry root and root
Stem: warm in nature, sweet in the mouth, micro-hardship, return liver, stomach warp, there is hemostasis, dissipating blood stasis, detumescence, the effect of pain relieving, cure mainly: control haematemesis, hemoptysis, nosebleed
The cards such as blood, has blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain, modern
Pharmacology proves, Radix Notoginseng can be stopped blooding, antithrombotic, promotion hemopoietic, antiinflammatory, protect the liver, antitumor, analgesia, cardiovascular is had good
Effect.
Ramulus Cinnamomi: latin name cinnamomi ramulus, is dried twig for canella Cortex Cinnamomi: acrid in the mouth, sweet, warm in nature, returns
The heart, lung, bladder warp, have a diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, effect of dispersing cold for relieving pain, Ramulus Cinnamomi warming the meridian and promoting blood circulation, horizontal logical
Podomere, for affection of exogenous wind-cold exterior syndrome, no matter having antiperspirant, lossless all can applying, also for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, bitterly
Warp, rheumatic arthralgia, take on the cards such as arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, cough with dyspnea
The phlegm retention syndromes such as dizziness.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel, there is promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, supports
Effect of blood and tranquilizing mind, cures mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, and skin infection swells and ache, vexed not
Sleep;Hepatosplenomegaly, angina pectoris etc. is demonstrate,proved.
Radix Paeoniae Rubra: bitter in the mouth, cold nature, return Liver Channel, have removing fire from the liver, clearing away heat and cooling blood, effect of stasis-dispelling and pain-killing, cure mainly high liver fire
Conjunctival congestion and swelling pain, have a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, macule is hemorrhage, and blood stasis amenorrhea;
The haematemesis hematuria of the burning hot absurd row of flourishing forcing blood;Women's heat in blood trip is through too much;Various pain caused by blood retardance;Heat in blood poison
The furuncle carbuncle of Sheng etc. are demonstrate,proved.
Cortex Moutan: bitter in the mouth, pungent, cold nature, enter the heart, liver, kidney channel, there is the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, mainly use
In the treatment epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, calentura later stage hot Fu Yin distribution heat, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, bitterly
Warp, carbuncle sore tumefacting virus, fall flutter the pain of injury, beriberoid pyretic arthralgia etc. card, Cortex Moutan is to bacillus subtilis, escherichia coli, Bacillus typhi, paratyphoid fever bar
Bacterium, Bacillus proteus, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, vibrio cholera etc. all have stronger antibacterial
Effect.
Rhizoma Corydalis: bitter in the mouth, pungent, warm in nature, enter liver, the heart, stomach warp, benefaction is wandered away, and can rise and can drop, and has promoting blood circulation to remove blood stasis, circulation of qi promoting
The effect of pain relieving, cures mainly obstruction of qi in the chest and cardialgia, coerces rib, all pains of gastral cavity abdomen, headache, lumbago, colicky, bones and muscles pain, dysmenorrhea, amenorrhea, puerperal
The cards such as the stasis of blood is suffered from abdominal pain, traumatic injury.
Fructus Forsythiae: bitter in the mouth, cold nature, enter the heart, liver, gallbladder, small intestine meridian, have heat-clearing and toxic substances removing, the effect of dispersing swelling and dissipating binds, for carbuncle
Cellulitis, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm is joined the army, high hot excessive thirst, and coma sends out speckle, the card such as pyretic stranguria urine retention
Treatment, has the strongest inhibitory action to dysentery bacterium, staphylococcus aureus.
Flos Lonicerae: latin name loniceraejaponicaeflos, sweet in the mouth, cold in nature, enter the heart, lung, stomach, large intestine channel, have clear
The effect of thermal detoxification, hold concurrently can eliminating pathogenic heat from blood to cure dysentery, be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is relatively contained, or epidemic febrile disease still exist from the beginning of pathogenic heat
The part of the body cavity above the diaphragm housing the heart and lungs and the most descending time;Pyretic toxicity dysentery, stool hematochezia;Fever disease in summer is demonstrate,proved;The carbuncle sore of pyretic toxicity accumulation is from the beginning of, the heat person of swelling and ache, Yi Jiqi
His skin infection, this thing has preferable antipyretic effect, has antiinflammatory action, can promote the phagocytic function of leukocyte, to streptococcus pneumoniae,
Bacillus typhi etc. have obvious inhibitory action.
Styrax: acrid in the mouth, warm in nature, GUIXIN warp, spleen channel, have and open surreptitiously, ward off dirty, effect of pain relieving, for apoplexy syncope due to accumulation of phlegm, sudden
So fainting, chest and abdomen cold type of pain, infantile convulsion etc. is demonstrate,proved.
Xinhui tangerine peel: bitter in the mouth, pungent, warm in nature.Regulate the flow of vital energy, spleen invigorating, dampness, function of reducing phlegm.For fullness in the epigastrium and chest, emotional vomiting
Tell, inappetence, cough with copious phlegm.
Cortex Magnoliae Officinalis: bitter in the mouth, pungent, warm in nature, return spleen channel;Stomach warp;Large intestine channel, has circulation of qi promoting removing food stagnancy;Dampness is except full;Lowering the adverse QI to relieve asthma
Effect, cures mainly stagnation of QI due to dyspepsia;Abdominal distention constipation;Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea;Expectorant stops up QI rising in reverse order;Fullness in the chest such as is breathed with cough at the card.
The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature, enter spleen, stomach, large intestine, gallbladder meridian, have the effect of week pain relieving, all gas can be lifted, the longest
Stagnant in row the intestines and stomach, leads the heap soil or fertilizer over and around the roots of three Jiao;The card of all mechanism of qi retardances, such as the intestines and stomach stagnation of QI, upper for vomiting, in be distension and fullness in the abdomen, under be
Having loose bowels, it may also be used for the damp and hot stagnant dysentery of the intestines and stomach, the symptom such as tenesmus, to transmissible gastroenteritis, Bacillus typhi, hay bar
Bacterium, dysentery bacterium have inhibitory action.
Fructus Crataegi: latin name Crataegi Fructus, sour in the mouth, sweet, slightly warm in nature, return spleen, stomach, Liver Channel, be used for helping digestion strong
Stomach, circulation of qi promoting dissipating blood stasis, it is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, Fructus Crataegi is the regular supplies for the treatment of dyspepsia, Fructus Crataegi energy
Increase the secretion of peptic digestion enzyme, facilitating digestion;Dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc. are had
Significantly inhibitory action.
Monas cuspurpureus Went: latin name Fermentum Rubrum, sweet in the mouth, warm in nature, return liver, spleen, stomach, large intestine channel, there is blood circulation promoting and blood stasis dispelling;
Effect of strengthening the spleen to promote digestion.Cure mainly eating accumulation;Distension and fullness in the abdomen;Red white dysentery;Prolonged lochia;Traumatic injury etc. are demonstrate,proved.
Radix Puerariae: latin name Puerariae Thomsonii Radix, sweet in the mouth, pungent, cool in nature, enter spleen, stomach warp, have inspiration stomach
Gas, clearing away heat and promoting production of body fluid, expelling pathogenic factors from muscles is delivered, raw positive, oozes the effect of rash, is mainly used in fever caused by exogenous pathogens, headache, stiff nape and back, and calentura is thirsty,
Quench one's thirst;Diarrhea due to hypofunction of the spleen, clear YANG failing to ascend etc. is demonstrate,proved.
Radix Rhodiolae: sweet in the mouth, bitter, property is put down, and returns lung, heart channel, has benefiting QI for activating blood circulation, and effect relievingd asthma of promoting blood circulation, for deficiency of vital energy blood
The stasis of blood, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma etc. is demonstrate,proved.
Folium Ginkgo: sweet in the mouth, hardship, puckery, property is put down, and enters the heart, lung meridian, and having astringes the lung relievings asthma, invigorate blood circulation nourish heart, the merit of relieving diarrhea with astringents
Effect, for cough and asthma due to lung deficiency, uncomfortable in chest pained, dizziness headache, to have loose bowels, dysentery etc. is demonstrate,proved.
Scorpio: acrid in the mouth, property is put down, is returned Liver Channel, have endogenous wind stopping spasmolytic, dispersing pathogen accumulation, effect of removing obstruction in the collateral to relieve pain, cures mainly children's and shies
Wind, tic spasm, the cards such as middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature, enters the heart, lung, stomach warp, has the work that nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, heat clearing away are nourished heart
With, be mainly used in pathogenic dryness impairing the lung or lung-dryness syndrome due to deficiency of YIN have the dry cough expectorant of heat to stick, chronic cough hemoptysis, dry pharynx dryness in the nasal cavity, lung abscess, thermal burn stomach-Yin or
Dry mouth and throat caused by deficiency of stomach-Yin, red tongue lacks tongue, vague epigastralgia, and interior-heat is quenched one's thirst, and constipation due to dry stool, deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed
And the heart-nutriment and the dysphoria and insomnia that causes, crimson tongue and dry wait card.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, enter lung, the heart, kidney channel, there is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, the work of kidney calming
With.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat disappears
Yearningly, palpitation and insomnia etc. is demonstrate,proved, and Fructus Schisandrae Chinensis has cardiotonic. its infusion and dilute alcohol immersion, and contractile force can be strengthened, increase blood vessel and open
Power.
Weight preferred Radix Astragali 55g~65g of each crude drug of described Chinese medicine preparation, Radix Angelicae Sinensis body 15g~20g, Radix Ginseng 10g
~20g, Arillus Longan 15g~20g, Rhizoma Chuanxiong 15g~20g, Borneolum Syntheticum 5g~10g, Radix Notoginseng powder 5g~10g, Ramulus Cinnamomi 10g~15g, Radix Salviae Miltiorrhizae
15g~25g, Radix Paeoniae Rubra 15g~20g, Cortex Moutan 10g~20g, Rhizoma Corydalis 30g~35g, Fructus Forsythiae 15g~20g, Flos Lonicerae 10g~
20g, Styrax 10g~15g, Xinhui tangerine peel 10g~15g, Cortex Magnoliae Officinalis 10g~15g, the Radix Aucklandiae 15g~20g, Fructus Crataegi 25g~30g,
Monas cuspurpureus Went 10g~15g, Radix Puerariae 30g~35g, Radix Rhodiolae 15g~20g, Folium Ginkgo 10g~15g, Scorpio 5g~8g, Radix Ophiopogonis 25g
~35g and Fructus Schisandrae Chinensis 10g~20g.
Weight further preferred Radix Astragali 60g~65g of each crude drug of described Chinese medicine preparation, Radix Angelicae Sinensis body 15g~20g, life
Shine ginseng 10g~15g, Arillus Longan 15g~20g, Rhizoma Chuanxiong 15g~20g, Borneolum Syntheticum 5g~8g, Radix Notoginseng powder 5g~10g, Ramulus Cinnamomi 10g~
15g, Radix Salviae Miltiorrhizae 15g~20g, Radix Paeoniae Rubra 15g~20g, Cortex Moutan 10g~15g, Rhizoma Corydalis 30g~35g, Fructus Forsythiae 15g~20g, gold silver
Flower 15g~20g, Styrax 10g~15g, Xinhui tangerine peel 10g~15g, Cortex Magnoliae Officinalis 10g~15g, the Radix Aucklandiae 15g~20g, Fructus Crataegi
25g~30g, Monas cuspurpureus Went 10g~15g, Radix Puerariae 30g~35g, Radix Rhodiolae 15g~20g, Folium Ginkgo 10g~15g, Scorpio 5g~8g,
Radix Ophiopogonis 30g~35g and Fructus Schisandrae Chinensis 10g~15g.
The weight of each crude drug of described Chinese medicine preparation most preferably Radix Astragali 60g, Radix Angelicae Sinensis body 20g, Radix Ginseng 15g, Arillus Longan
15g, Rhizoma Chuanxiong 15g, Borneolum Syntheticum 8g, Radix Notoginseng powder 5g, Ramulus Cinnamomi 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Cortex Moutan 15g, Rhizoma Corydalis 30g, Fructus Forsythiae
15g, Flos Lonicerae 15g, Styrax 10g, Xinhui tangerine peel 10g, Cortex Magnoliae Officinalis 15g, Radix Aucklandiae 20g, Fructus Crataegi 25g, Monas cuspurpureus Went 15g, Radix Puerariae
30g, Radix Rhodiolae 15g, Folium Ginkgo 10g, Scorpio 8g, Radix Ophiopogonis 30g and Fructus Schisandrae Chinensis 15g.
Present invention also offers preparation method when above-mentioned Chinese medicine preparation is prepared as oral liquid, specifically include:
The first step, takes each crude drug by above-mentioned weight, cleans respectively, pulverizes, mixes, it is thus achieved that mixture, add water
Decocting secondary, add relative to mixture quality 4~the water of 6 times for the first time, decoct 2~3 hours, second time adds relative to mixture
Quality 2~the water of 4 times, decoct 1~2 hour, collecting decoction, filters, and being concentrated into relative density is 1.05~1.10 (60 DEG C)
Clear paste, stands 24 hours, filters, decompression filtrate recycling ethanol, is dried, it is thus achieved that dry cream, and the dry cream obtained is placed on superfine powder
Broken machine is pulverized 1~2 hour, pulverizes, sieve, it is thus achieved that 300 mesh~the micropowders of 400 mesh;
Second step, takes micropowders prepared by the 500g first step, adds sucrose 50g, ethyl hydroxybenzoate 0.5g, sodium benzoate
0.3g, appropriate distilled water is heated to 30 DEG C~40 DEG C, is stirred to dissolve completely, refilters once after cold preservation 5h, and filtrate continues to add
Add distilled water adjust volume to 1000ml, stir evenly, filter, fill, sterilizing, obtain oral liquid.
Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means
Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 oral liquid 1
Take Radix Astragali 60g, Radix Angelicae Sinensis body 20g, Radix Ginseng 15g, Arillus Longan 15g, Rhizoma Chuanxiong 15g, Borneolum Syntheticum 8g, Radix Notoginseng powder 5g, osmanthus
Branch 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Cortex Moutan 15g, Rhizoma Corydalis 30g, Fructus Forsythiae 15g, Flos Lonicerae 15g, Styrax 10g, newly can be old
Skin 10g, Cortex Magnoliae Officinalis 15g, Radix Aucklandiae 20g, Fructus Crataegi 25g, Monas cuspurpureus Went 15g, Radix Puerariae 30g, Radix Rhodiolae 15g, Folium Ginkgo 10g, Scorpio 8g, wheat
Door winter 30g and Fructus Schisandrae Chinensis 15g, cleans respectively, pulverizes, mixes, it is thus achieved that mixture, boiling secondary, adds for the first time
The water of 2.2kg, decocts 3 hours, and second time adds the water of 1.5kg, decocts 2 hours, collecting decoction, filters, is concentrated into relative density
It is the clear paste of 1.10 (60 DEG C), stands 24 hours, filter, decompression filtrate recycling ethanol, be dried, it is thus achieved that dry cream, dry by obtain
Cream is placed in super micron mill pulverizing 1 hour, pulverizes, sieves, it is thus achieved that the micropowders of 400 mesh, take 500g micropowders, add
Entering sucrose 50g, ethyl hydroxybenzoate 0.5g, sodium benzoate 0.3g, appropriate distilled water is heated to 30 DEG C~40 DEG C, has been stirred to dissolve
Entirely, refiltering once after cold preservation 5h, filtrate continuation interpolation distilled water adjustment volume, to 1000ml, stirs evenly, filters, fill, sterilizing,
Obtain oral liquid.
Embodiment 2 oral liquid 2
Take Radix Astragali 60g, Radix Angelicae Sinensis body 20g, Radix Ginseng 10g, Arillus Longan 15g, Rhizoma Chuanxiong 15g, Borneolum Syntheticum 5g, Radix Notoginseng powder 5g, osmanthus
Branch 10g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 15g, Cortex Moutan 10g, Rhizoma Corydalis 30g, Fructus Forsythiae 15g, Flos Lonicerae 15g, Styrax 10g, newly can be old
Skin 10g, Cortex Magnoliae Officinalis 10g, Radix Aucklandiae 15g, Fructus Crataegi 25g, Monas cuspurpureus Went 10g, Radix Puerariae 30g, Radix Rhodiolae 15g, Folium Ginkgo 10g, Scorpio 5g, wheat
Door winter 30g and Fructus Schisandrae Chinensis 10g, cleans respectively, pulverizes, mixes, it is thus achieved that mixture, boiling secondary, adds for the first time
The water of 2.2kg, decocts 3 hours, and second time adds the water of 1.5kg, decocts 2 hours, collecting decoction, filters, is concentrated into relative density
It is the clear paste of 1.10 (60 DEG C), stands 24 hours, filter, decompression filtrate recycling ethanol, be dried, it is thus achieved that dry cream, dry by obtain
Cream is placed in super micron mill pulverizing 1 hour, pulverizes, sieves, it is thus achieved that the micropowders of 400 mesh, take 500g micropowders, add
Entering sucrose 50g, ethyl hydroxybenzoate 0.5g, sodium benzoate 0.3g, appropriate distilled water is heated to 30 DEG C~40 DEG C, has been stirred to dissolve
Entirely, refiltering once after cold preservation 5h, filtrate continuation interpolation distilled water adjustment volume, to 1000ml, stirs evenly, filters, fill, sterilizing,
Obtain oral liquid.
Embodiment 3 oral liquid 3
Take Radix Astragali 60g, Radix Angelicae Sinensis body 20g, Radix Ginseng 15g, Arillus Longan 20g, Rhizoma Chuanxiong 20g, Borneolum Syntheticum 8g, Radix Notoginseng powder 10g, osmanthus
Branch 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 20g, Cortex Moutan 15g, Rhizoma Corydalis 35g, Fructus Forsythiae 20g, Flos Lonicerae 20g, Styrax 15g, newly can be old
Skin 15g, Cortex Magnoliae Officinalis 15g, Radix Aucklandiae 20g, Fructus Crataegi 30g, Monas cuspurpureus Went 15g, Radix Puerariae 35g, Radix Rhodiolae 20g, Folium Ginkgo 15g, Scorpio 8g, wheat
Door winter 35g and Fructus Schisandrae Chinensis 15g, cleans respectively, pulverizes, mixes, it is thus achieved that mixture, boiling secondary, adds for the first time
The water of 2.2kg, decocts 3 hours, and second time adds the water of 1.5kg, decocts 2 hours, collecting decoction, filters, is concentrated into relative density
It is the clear paste of 1.10 (60 DEG C), stands 24 hours, filter, decompression filtrate recycling ethanol, be dried, it is thus achieved that dry cream, dry by obtain
Cream is placed in super micron mill pulverizing 1 hour, pulverizes, sieves, it is thus achieved that the micropowders of 400 mesh, take 500g micropowders, add
Entering sucrose 50g, ethyl hydroxybenzoate 0.5g, sodium benzoate 0.3g, appropriate distilled water is heated to 30 DEG C~40 DEG C, has been stirred to dissolve
Entirely, refiltering once after cold preservation 5h, filtrate continuation interpolation distilled water adjustment volume, to 1000ml, stirs evenly, filters, fill, sterilizing,
Obtain oral liquid.
Embodiment 4 drug toxicology is tested
Acute toxicity testing
Laboratory animal: SD rat, grade: SPF level, sex: male and female half and half, quantity: 40, body weight 180~220g.
Experimental agents: the Chinese medicine preparation oral liquid 1 of the embodiment of the present invention 1 preparation, water bath with thermostatic control is heated, is condensed into crude drug dense
Degree 1.25g/ml, standby.
Animal feeding environmental condition: temperature 20~26 DEG C, humidity 40~70%.
Route of administration: gavage, is administered volume 40ml/kg, is administered 3 times in 24 hours.
Animal is grouped: taking the SD rat weight that quarantine is qualified, be randomly divided into 2 groups by body weight, every treated animal 20, male and female are each
Half.
It is administered: water is can't help in each Mus fasting, and after 12 hours, administration group presses 40ml/kg body weight gavage Chinese medicine oral liquid of the present invention
Solution after process, crude drug concentration 1.25g/ml, it is administered 3 times in 24 hours, then Continuous Observation 14 days.
General observation of symptoms: observed content includes drinking-water, feed, outward appearance sign, general behavior are movable.
Observing time: Continuous Observation 14 days after administration.
Observed frequency: test the same day be administered after 1/2,1,2,3,4,6,8h.Test the 2nd day to the 14th day, morning every day, under
Noon respectively observes once.
Observed and recorded: record toxic reaction symptom occurs, increases the weight of, alleviates and the time of death.
Body weight: weigh SD rat body weight next day of rising for after administration the 2nd day.
Anatomic observation: be administered the 14th day, puts to death and gross anatomy animal, and the perusal heart, liver, spleen, lung, kidney etc. are the dirtiest
Device is with or without pathological changes, and ill dirty device carries out pathologic finding.
Experimental result
General observation of symptoms result
After solution after 3 gavage Chinese medicine oral liquid of the present invention process in 24 hours, SD rat drinking-water, feed, outward appearance body
Levy, general behavior activity all normal, observe and have no SD rats death in 14 days.
Body weight observed result
After administration, SD activities in rats is normal.In observing 14, animal has no dead, and general status is good, diet, two the most just
Often, and outward appearance, fur, behavior, breathing are all normal, nose, eye, oral cavity secretions without exception, after the administration of administration group male rat
4th day body weight statistically significant with matched group comparing difference outer (P < 0.05), has no other obvious abnormal response.
Anatomic observation result
SD rat is put to death in observation after terminating, each main organs color and luster such as the gross anatomy perusal heart, liver, spleen, lung, kidney,
The no abnormality seen such as shape, size.
Maximum dosage-feeding calculates
The maximum dosage-feeding that Chinese medicine preparation oral liquid SD rat oral gavage of the present invention is administered is 150g/kg/d, and this dosage is to face
Bed adult's (body weight is based on 60kg) daily dosage is 40g/d conversion, is equivalent to the 1352.25 of clinical adult's consumption (0.67g/kg)
Times, modern pharmacology is thought, zoopery is administered more than 100 times for human body dosage, and without obvious toxic-side effects and without late
Send out toxic reaction, i.e. it is believed that this medicine is without obvious toxic-side effects, therefore studied by Chinese medicine preparation acute toxicity testing of the present invention,
Its dosage is 2884.8 times of human body dosage, it is believed that it has good safety.
Long term toxicity test is studied
Investigating in SD rat 30, every day is administered for continuous 2 times, the concentration drawn by anxious toxicity test, according to its 0.7 times and
After the Chinese medicine oral liquid 1 of the 0.49 times of gavage embodiment of the present invention 1 preparation, chronic toxicity produced by animal and toxic reaction
First target organs, provide safety foundation for clinical long-term prescription.
Laboratory animal: with anxious toxicity test.
Experimental agents: the Chinese medicine oral liquid 1 of the embodiment of the present invention 1, the same acute toxicity test of preparation method, obtain being equivalent to life
Concentration 0.875g/ml, 0.6125g/ml, standby.
Animal feeding and management: same to acute toxicity test.
Route of administration: the same acute toxicity test of route of administration, successive administration 30 days.
Animal is grouped: taking the SD rat weight that quarantine is qualified, be randomly divided into 3 groups by body weight, every treated animal 20, male and female are each
Half.
It is administered: the same acute toxicity test of medication, gives and normal saline, high dose, the low dosage embodiment of the present invention 1 respectively
Chinese medicine preparation oral liquid 1.
Observation item and index: with anxious toxicity test.
Experimental result
General observation of symptoms result: after the solution after 2 gavage Chinese medicine oral liquid of the present invention process every day, SD rat drinks
Water, feed, outward appearance sign, general behavior activity are all normal, and Continuous Observation has no SD rats death in 30 days.
Body weight observed result: after administration, SD activities in rats is normal.In observing 30, animal has no dead, and general status is good
Good, diet, two just normal, and outward appearance, fur, behavior, breathing are all normal, nose, eye, oral cavity secretions without exception, with matched group
Relatively, reaction, no statistical difference difference are shown no obvious abnormalities.
Anatomic observation result: observe and put to death SD rat after terminating, the gross anatomy perusal heart, liver, spleen, lung, kidney etc. are each
The no abnormality seens such as main organs color and luster, shape, size.
Maximum dosage-feeding calculates: the maximum dosage-feeding that Chinese medicine preparation oral liquid SD rat oral gavage of the present invention is administered is 70g/
Kg, 49g/kg, this dosage is 0.3g conversion by clinic adult's (body weight is based on 60kg) daily dosage, is equivalent to clinical adult's consumption
(0.67g/kg) 627.91 times, 439.54 times, modern pharmacology is thought, zoopery is administered successive administration 30 days, animal without
Obvious toxic-side effects, also without obvious cumulative toxicity, it is believed that it has good safety.
Embodiment 5 experimentation
Medicine and reagent
The Chinese medicine oral liquid 1 of the embodiment of the present invention 1 preparation, concentrates and is prepared as, containing crude drug 2g/ml, saving backup.
FUFANG DANSHEN ZHUSHEYE, Shanghai Westen and Chinese Tranditional Medicine Pharamacentic Co., Ltd's product, containing extracts from crude drugs 2g/ml;
NBT, Chinese Medicine group Solution on Chemical Reagents in Shanghai Products;
Lactic dehydrogenase enzyme reagent kit, converge Pharmaceutical Technology Co., Ltd's product in upper Haifeng county;
Creatine phosphokinase test kit, converge Pharmaceutical Technology Co., Ltd's product in upper Haifeng county;
Heparin sodium injection, the biochemical thousand red pharmaceutical Co. Ltd products in Changzhou;
Adrenalin hydrochloride injection, 1mg/ml, Wuhan pharmacy (group) joint-stock company product;
Active partial thromboplastin time (APTT) measures test kit, prothrombin time (TT) measures test kit and fiber
The proteinogen time (FT) measures test kit, is Diagnostics, USA imported product.
Animal
SD rat, SPF level, male, body weight 180~220g, 40, body weight 350~400g, 40.
Experimental technique
Rat coronary artery ligation model
Choose SD rat, 40, male, it is randomly divided into normal group, model group, invention group, FUFANG DANSHEN ZHUSHEYE comparison
Group (Radix Salviae Miltiorrhizae group).After animal gavage pentobarbital sodium 40mg/kg anesthesia, circulation of qi promoting cannula, connect artificial respirator, manually exhale
Inhale, at left breast fourth, fifth intercostal incision skin and Musclar layer, expose thoracic cavity with expander, cut off pericardium, before coronary artery
Hindering stitching thread following coronary artery occlusion with medical non-destructive at offset distance opening part 2~3mm, close thoracic cavity, electrocardiogram two ST-Segment is bright
The aobvious person of raising takes.Normal group animal is in addition to not following coronary artery occlusion, and other operation processs are identical with model group, i.e. cause and do evil through another person
Art.
Suture muscles layer and skin layer after following coronary artery occlusion or sham-operation, normal group and model group gavage physiology salt
Water, is administered by 0.1ml/100g body weight;Invention group gives the molten of crude drug concentration 2g/ml of embodiment 1 Chinese medicine oral liquid 1 preparation
Liquid, is administered by 0.1ml/100g body weight, and Radix Salviae Miltiorrhizae group gives FUFANG DANSHEN ZHUSHEYE, gives and gavage by drug administration by injection two multiple dose,
I.e. press 0.2ml/100g body weight, gavage 2g/ml FUFANG DANSHEN ZHUSHEYE.Gavage relative medicine again after 4h, dosage is the same.24h
Pneumoretroperitoneum venous blood sampling, is performing centrifugal separation on obtaining blood serum sample, measures its lactic acid dehydrogenase with BTS-370 automatic biochemistry analyzer
And creatine phosphokinase (CK) content, and respectively organize difference (LDH).After taking blood, take out rat heart immediately, use normal saline
Clean hematocele in the chambers of the heart, remove atrium and fat, claim the left heart and weigh whole-heartedly, by crosscutting for myocardium of left ventricle 5~8, put into test tube
In, then toward the phosphate buffer about 3ml of addition chloride containing nitro blue tetrazolium (5mg/ml) in test tube, put in 37 DEG C of waters bath with thermostatic control
Dye about 10min, cleans with normal saline, cuts ischemic tissue's (not dyeing or lark) and weigh, calculate after tissue staining
Infarcted myocardium accounts for percentage by weight whole-heartedly, and respectively organizes difference.
Rat acute syndrome of blood stasis model
Take rat, body weight 350~400g, be randomly divided into 4 groups, be i.e. normal group, model group, Radix Salviae Miltiorrhizae group and invention group, with hat
The identical administering mode of shape artery ligation model experiment and dosage, successive administration 6d, after the 5th is administered, in addition to normal group, each group
Animal skins hemostasis adrenalin hydrochloride injection 0.8mg/kg, injects after the 4h of interval 1 time again, totally 2 times, injects kidney at the 2nd time
Before upper parathyrine, rat is placed in frozen water immersion 5min, causes syndrome of blood stasis model.After fasting 24h, give in operation consent 15min
Medicine 1 time, anaesthetizes with 10% chloral hydrate (300mg/kg, ip), faces upward position and fix, and carotid artery intubates blood-letting, uses 3.8% sodium citrate
Or heparin sodium normal saline solution (heparin 500u/ml) is by 1: 9 anticoagulant, detects hemorheological indices.
Statistical method
Institute resultful significant difference inspection all use t inspection process, result withRepresent.
Result of the test
To the anti-myocardial infarction effect of rat after following coronary artery occlusion
As seen from Table 1, invention group can reduce myocardial infarction area;As seen from Table 2, three dosage of Chinese medicine preparation of the present invention are equal
Serum LDH and CK level can be significantly reduced.Result above is pointed out, and rat following coronary artery occlusion is caused by Chinese medicine preparation of the present invention
Ischemic cardiac muscle infarction has certain therapeutical effect.
The comparison of rat myocardial infarction model area respectively organized by table 1
Packet | N | Myocardial infarct size |
Normal group | 10 | 0±0* |
Model group | 10 | 28.3±8.4 |
Radix Salviae Miltiorrhizae group | 10 | 24.7±6.4 |
Invention group | 10 | 12.1±5.4* |
Compare with model group,*P<0.05
The comparison of rat LDH and CK respectively organized by table 2
Packet | N | CK(U/L) | LDH(U/L) |
Normal group | 10 | 723±382* | 1101±698* |
Model group | 10 | 1437±854 | 3224±1989 |
Radix Salviae Miltiorrhizae group | 10 | 663±321* | 863±422* |
Invention group | 10 | 658±247* | 1512±918* |
Compare with model group,*P<0.05
Chinese medicine preparation of the present invention is to acute blood-stasis rat blood rheology
Chinese medicine preparation of the present invention can reduce cerebral lucunar infarction, reduces whole blood viscosity (in cut, undercut) and plasma viscosity,
Increase erythrocyte deformability.
Table 3 respectively organizes Rat Erythrocytes viscosity, the comparison of erythrocyte deformability
Packet | N | RBC deformability | RBC aggregation extent |
Normal group | 10 | 52.38±2.14* | 1.39±0.72* |
Model group | 10 | 49.03±2.97 | 2.21±0.53 |
Radix Salviae Miltiorrhizae group | 10 | 52.51±3.21* | 1.61±0.49 |
Invention group | 10 | 52.81±2.46* | 1.51±0.48* |
Compare with model group,*P<0.05
Conclusion
By experimentation of the present invention, it was demonstrated that Chinese medicine preparation of the present invention anti-heart infarction function well, indirect reaction device is to arteria coronaria
Blood supply insufficiency has good improvement result, passes through Analysis of Hemorheological Properties, it was demonstrated that its have well improve hemorheology make
With, there is good therapeutical effect for TCM Blood Stasis & Blood type.
Embodiment 6 clinical research
Physical data
Randomly draw 138 example myocardial ischemia that my institute treats in April ,-2015 in March, 2014 with uncomfortable in chest, breathe hard, weak
For the patient of principal agent symptom, wherein 71 example male, 67 example women, patient age is between 27~79 years old, and the mean age is 52.1.
Patients with Myocardial Ischemia being divided into two groups: observation group and matched group, contrast the related data of two groups of patients, difference is failed to understand
Aobvious, do not possess statistical significance (P > 0.05), have comparability.Patient all gets rid of valvular heart disease, conduction block, heart failure, cardiac muscle
The diseases such as disease.
Diagnostic criteria
In ST section electrocardiogram, general level decrease beyond T ripple in 0.1mV, and the electrocardiogram having and changes;ST section is sagging
Type and horizontal type force down more than 1mV, and the time is more than 1min, it is possible to determine that myocardial ischemia occurs in patient.And patient is at 24h
In, the number of times that ischemic-type changes is more than 10 times, and patient just belongs to positive.
Therapeutic Method
In observation group, patient uses TCM Therapy to treat, and uses the Chinese medicine oral liquid of the embodiment of the present invention 1 preparation
1,100ml/ time, 2 times/day.Patient takes 3~6 months;
In matched group, patient uses Nifedipine sustained release tablets to treat, every day 2-3 time, 10-60mg/ time, needs patient
Take 2-6 month continuously.
Ischemia evaluation criterion
According to patient's ischemia number of times evaluation in 24h.In 24h, ischemia number of times is less than 3 times, belongs to slight;Lack in 24h
Blood number of times is less than 5 times, belongs to moderate;In 24h, ischemia number of times is more than 10 times, belongs to severe.
Criterion of therapeutical effect
Effective: after treating 1 course for the treatment of, the ST section ischemic-type of patient disappears, and ischemia number of times is less than 2 times in 24h,
The primary underlying pathology of patient is effectively improved, and the ambulatory electrocardiogram of patient is normal in 2-6 month, does not occur heart anxious
Sexual behavior part;
Effective: after accepting to treat 1 course for the treatment of, the ischemic ST-segment in patient ECG disappears, and ambulatory electrocardiogram
The ischemia number of times detected in 24h is less than 3 times, and the primary underlying pathology of patient is improved or do not deteriorates,
In 2-6 month dynamic ecg monitoring to patient's ischemia number of times do not increase, heart acute events does not occur;
Invalid: after treatment patients, it is not reaching to treat effective standard, or patient is during accepting treatment
There is angina pectoris or heart acute events
Result
The therapeutic effect of two groups of patients compares (%)
The treated effect of 4 liang of table group patient compares
Group | Number of cases | Effective | Effectively | Invalid | Effective percentage |
Observation group | 71 | 34 | 27 | 3 | 95.77 |
Matched group | 67 | 26 | 32 | 9 | 86.57 |
Table 5 patient treat 2 weeks, 4 weeks, 6 weeks time the obvious number of cases of therapeutic effect compare
6 liang of table group patient is at the Clinical efficacy comparison of target indication
Conclusion
Being observed by clinical trial medication, Chinese medicine preparation of the present invention has reached the therapeutical effect identical with Western medicine, P > 0.05,
But comparing its total effective rate and improve time-effect relationship, Chinese drug-treated group of the present invention is better than matched group, therefore, the overall merit present invention
Chinese medicine preparation Clinical practice is safe and effective.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints
What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc.
Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit of the foundation present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.
Claims (6)
1. one kind treat heart pass after Chinese medicine preparation uncomfortable in chest, it is characterised in that: crude drug includes Radix Astragali, Radix Angelicae Sinensis body, life
Shine ginseng, Arillus Longan, Rhizoma Chuanxiong, Borneolum Syntheticum, Radix Notoginseng powder, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Cortex Moutan, Rhizoma Corydalis, Fructus Forsythiae, Flos Lonicerae, Styrax,
Xinhui tangerine peel, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Crataegi, Monas cuspurpureus Went, Radix Puerariae, Radix Rhodiolae, Folium Ginkgo, Scorpio, Radix Ophiopogonis and Fructus Schisandrae Chinensis.
2. Chinese medicine preparation uncomfortable in chest after treatment heart pass as claimed in claim 1, it is characterised in that: the weight of each crude drug
For Radix Astragali 55g~65g, Radix Angelicae Sinensis body 15g~20g, Radix Ginseng 10g~20g, Arillus Longan 15g~20g, Rhizoma Chuanxiong 15g~20g, ice
Sheet 5g~10g, Radix Notoginseng powder 5g~10g, Ramulus Cinnamomi 10g~15g, Radix Salviae Miltiorrhizae 15g~25g, Radix Paeoniae Rubra 15g~20g, Cortex Moutan 10g~
20g, Rhizoma Corydalis 30g~35g, Fructus Forsythiae 15g~20g, Flos Lonicerae 10g~20g, Styrax 10g~15g, Xinhui tangerine peel 10g~
15g, Cortex Magnoliae Officinalis 10g~15g, the Radix Aucklandiae 15g~20g, Fructus Crataegi 25g~30g, Monas cuspurpureus Went 10g~15g, Radix Puerariae 30g~35g, Radix Rhodiolae
15g~20g, Folium Ginkgo 10g~15g, Scorpio 5g~8g, Radix Ophiopogonis 25g~35g and Fructus Schisandrae Chinensis 10g~20g.
3. Chinese medicine preparation uncomfortable in chest after treatment heart pass as claimed in claim 1 or 2, it is characterised in that: each crude drug
Weight is Radix Astragali 60g~65g, Radix Angelicae Sinensis body 15g~20g, Radix Ginseng 10g~15g, Arillus Longan 15g~20g, Rhizoma Chuanxiong 15g~
20g, Borneolum Syntheticum 5g~8g, Radix Notoginseng powder 5g~10g, Ramulus Cinnamomi 10g~15g, Radix Salviae Miltiorrhizae 15g~20g, Radix Paeoniae Rubra 15g~20g, Cortex Moutan 10g
~15g, Rhizoma Corydalis 30g~35g, Fructus Forsythiae 15g~20g, Flos Lonicerae 15g~20g, Styrax 10g~15g, Xinhui tangerine peel 10g~
15g, Cortex Magnoliae Officinalis 10g~15g, the Radix Aucklandiae 15g~20g, Fructus Crataegi 25g~30g, Monas cuspurpureus Went 10g~15g, Radix Puerariae 30g~35g, Radix Rhodiolae
15g~20g, Folium Ginkgo 10g~15g, Scorpio 5g~8g, Radix Ophiopogonis 30g~35g and Fructus Schisandrae Chinensis 10g~15g.
4. Chinese medicine preparation uncomfortable in chest after the treatment heart pass as described in claims 1 to 3, it is characterised in that: each crude drug
Weight is Radix Astragali 60g, Radix Angelicae Sinensis body 20g, Radix Ginseng 15g, Arillus Longan 15g, Rhizoma Chuanxiong 15g, Borneolum Syntheticum 8g, Radix Notoginseng powder 5g, Ramulus Cinnamomi
15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Cortex Moutan 15g, Rhizoma Corydalis 30g, Fructus Forsythiae 15g, Flos Lonicerae 15g, Styrax 10g, Xinhui tangerine peel
10g, Cortex Magnoliae Officinalis 15g, Radix Aucklandiae 20g, Fructus Crataegi 25g, Monas cuspurpureus Went 15g, Radix Puerariae 30g, Radix Rhodiolae 15g, Folium Ginkgo 10g, Scorpio 8g, Mai Men
Winter 30g and Fructus Schisandrae Chinensis 15g.
5. Chinese medicine preparation uncomfortable in chest after the treatment heart pass as described in Claims 1-4, it is characterised in that: described Chinese medicine system
Agent is prepared as oral liquid.
6. the preparation method of Chinese medicine preparation described in Claims 1-4, it is characterised in that:
When being prepared as oral liquid, specifically include,
The first step, takes each crude drug by above-mentioned weight, cleans respectively, pulverizes, mixes, it is thus achieved that mixture, boiling
Secondary, adds relative to mixture quality 4~the water of 6 times for the first time, decocts 2~3 hours, and second time adds relative to mixture quality
The water of 2~4 times, decocts 1~2 hour, collecting decoction, filters, is concentrated into the clear paste that relative density is 1.05~1.10 (60 DEG C),
Stand 24 hours, filter, decompression filtrate recycling ethanol, be dried, it is thus achieved that dry cream, the dry cream obtained is placed in super micron mill
Pulverize 1~2 hour, pulverize, sieve, it is thus achieved that 300 mesh~the micropowders of 400 mesh;
Second step, takes micropowders prepared by the 500g first step, adds sucrose 50g, ethyl hydroxybenzoate 0.5g, sodium benzoate
0.3g, appropriate distilled water is heated to 30 DEG C~40 DEG C, is stirred to dissolve completely, refilters once after cold preservation 5h, and filtrate continues to add
Add distilled water adjust volume to 1000ml, stir evenly, filter, fill, sterilizing, obtain oral liquid.
Priority Applications (1)
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CN101628078A (en) * | 2008-07-14 | 2010-01-20 | 何立军 | Chinese medicinal preparation for treating ischemic cardiovascular diseases |
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CN103784820A (en) * | 2014-02-23 | 2014-05-14 | 曹小松 | Traditional Chinese medicine formula for treating cariac blood stasis type coronary heart disease |
CN108478731A (en) * | 2018-06-25 | 2018-09-04 | 江苏百剑药业科技有限公司 | Chinese medicine preparation and Chinese medicinal capsule for treating cardiovascular stasis coronary heart disease |
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CN101628078A (en) * | 2008-07-14 | 2010-01-20 | 何立军 | Chinese medicinal preparation for treating ischemic cardiovascular diseases |
CN103784888A (en) * | 2014-02-23 | 2014-05-14 | 曹小松 | Traditional Chinese medicine for treating coronary atherosclerotic heart disease caused by qi deficiency and blood stasis |
CN103784820A (en) * | 2014-02-23 | 2014-05-14 | 曹小松 | Traditional Chinese medicine formula for treating cariac blood stasis type coronary heart disease |
CN108478731A (en) * | 2018-06-25 | 2018-09-04 | 江苏百剑药业科技有限公司 | Chinese medicine preparation and Chinese medicinal capsule for treating cardiovascular stasis coronary heart disease |
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