CN105920574A - 一种治疗心悸病的药物及其制备方法 - Google Patents
一种治疗心悸病的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗心悸病的药物及其制备方法,其主要是由灵芝草、太子参、百合、玉竹、益母草、龙眼肉、五味子、茉莉花、苦参、柏子仁、川芎、黄芪、甘松、黄精、酸枣仁、甘草、桑椹、当归、龙齿、南沙参、连翘、前胡、莲子心、半夏、干姜按一定重量配比制备而成。本发明药物具有清心除烦,益胃生津,宁心安神,补肺健脾,益心脾,补气血的功能,用于治疗心悸病见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗心悸病的药物及其制备方法,属中药领域。
背景技术
心悸病患者自觉心跳或心慌,伴有心前区不适感,当心率缓慢常感到心脏搏动强烈,心率加快时可感到心脏跳动,甚至可感到心前区振动。中医则认为心悸病与素体虚弱,气血亏虚,情志所伤,外邪侵袭有关。由于西药治疗副作用大,因此人们对有效治疗心悸病的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗心悸病的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗心悸病的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择灵芝草、太子参、百合、玉竹、益母草、龙眼肉、五味子、茉莉花、苦参、柏子仁、川芎、黄芪、甘松、黄精、酸枣仁、甘草、桑椹、当归、龙齿、南沙参、连翘、前胡、莲子心、半夏、干姜、桂枝、麦冬、石菖蒲、泽泻、茵陈蒿、丹参、天花粉药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗心悸病。其中,选用灵芝草是因为其性味甘,平,有补气安神,止咳平喘的功能,治眩晕不眠,心悸气短,虚劳咳喘。选用太子参是因为其性味甘苦,微温,入心、脾、肺三经,有补肺、健脾的功能,治肺虚咳嗽,脾虚食少,心悸目汗,精神疲乏。选用百合是因为其性味甘微苦,平,入心、肺经,有润肺止咳,清心安神的功能,治肺痨久嗽,咳唾痰血,热病后余热未清,虚烦惊悸,神志恍惚,脚气浮肿。玉竹是因为其性味甘,平,入肺,胃经,有养阴,润燥,除烦,止渴的功能,治热病阳伤,咳嗽,烦渴,虚劳发热,消谷易饥,小便频数。选用益母草是因为其性味辛苦,凉,入心包、肝经,有活血,祛瘀,调经,消水的功能,治***,治漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。选用龙眼肉是因为其性味甘,温,入心、脾经,有益心脾,补气血,安神的功能,治虚功羸弱,失眠,健忘,惊悸,怔仲。选用五味子是因为其性味酸,温,入肺、肾经,有敛肺,滋肾,生津,收汗,涩精的功能,治肺虚喘咳,口干作渴,自汗,盗汗,劳伤羸瘦,梦遗滑精,久泻久痢。选用茉莉花是因为其性味辛甘,温,有理气,开郁,辟秽,和中的功能,治下痢腹痛,结膜炎,疮毒。选用苦参是因为其性味苦,寒,入肝、肾、大肠、小肠经,有清热,燥湿,杀虫的功能,治热毒血痢,肠风下血,黄疸,赤白带下,小儿肺炎,疳积,急性扁桃体炎,痔漏,脱肛,皮肤瘙痒,阴疮湿痒,瘰疬,烫伤。选用柏子仁是因为其性味甘,平,入心、肝、脾经,有养心安神,润肠通便的功能,治惊悸,失眠,遗精,盗汗,便秘的功能。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用甘松是因为其性味甘,温,入脾、胃经,有理气止痛,醒脾健胃,治胃痛,胸腹胀满,头痛,癔病,脚气。选用黄精是因为其性味甘平,入脾、肺、肾经,有补中益气,润心肺,强筋骨的功能,治虚损寒热,肺痨咳血,病后体虚食少,筋骨软弱,风湿疼痛,风癞癣疾。选用酸枣仁是因为其性味甘,平,入心、脾、肝、胆经,有养肝,宁心,安神,敛汗的功能,治虚烦不眠,惊悸怔忡,烦渴,虚汗。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用桑椹是因为其性味甘,寒,入肝、肾经,有补肝,益肾,熄风,滋液的功能,治肝肾阴亏,消渴,便秘,目暗,耳鸣,瘰疬,关节不利。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治***,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用龙齿是因为其性味涩,凉,入心、肝经,有镇惊安神,除烦热的功能,治惊癎癫狂,烦热不安,失眠多梦。选用南沙参是因为其性味甘,微寒,归肺、胃经,有养阴清肺,化痰,益气的功能,治肺热燥咳,阴虚劳咳,干咳痰黏,气阴不足,烦热口干。选用连翘是因为其性味苦,凉,入心、肝、胆经,有清热,解毒,散结,消肿的功能,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。选用前胡是因为其性味辛、苦,微寒,归肺经,有散风清热,降气化痰的功能,治风热咳嗽,痰多,痰热喘满,咯痰黄稠。选用莲子心是因为其性味苦寒,归心、肺、肾三经,有清心,去热,止血,涩精的功能,治心烦,口渴,吐血,遗精。选用半夏是因为其性味辛,温,有毒,入脾、胃经,有燥湿化痰,降逆止呕,消痞散结的功能,治湿痰冷饮,呕吐,反胃,咳喘痰多,胸膈胀满,痰厥头痛,头晕不眠,外消痈肿。选用干姜是因为其性味辛,热,入脾、胃、肺经,有温中逐寒,回阳通脉的功能,治心腹冷痛,吐泻,肢冷脉微,寒饮喘咳,风寒湿痹,阳虚吐、衄、下血。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用麦冬是因为其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的功能,治肺燥干咳,吐血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用石菖蒲因为其性味辛,微温。入心、肝、脾经。开窍,豁痰,理气,活血,散风,去湿。治癫痫,痰厥,热病神错,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用茵陈蒿是因为其性味苦辛,凉,入肝、脾、膀胱经,有清热利湿的功能,治湿热黄疸,小便不利,风痒疮疥。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,***,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用天花粉是因为其性味甘苦酸,凉,入肺、胃经,有生津,止渴,降火,润燥,排脓,消肿的功能,治热病口渴,消渴,黄疸,肺燥咳血,痈肿,痔瘘。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效.
灵芝草15-25克,太子参10-20克,百合10-20克,玉竹10-15克,益母草10-20克,龙眼肉10-20克,五味子7-12克,茉莉花5-15克,苦参10-20克,柏子仁10-15克,川芎10-20克,黄芪5-15克,甘松5-15克,黄精10-20克,酸枣仁10-15克,甘草10-20克,桑椹10-20克,当归5-15克,龙齿5-15克,南沙参7-12克,连翘5-15克,前胡7-12克,莲子心7-12克,半夏5-15克,干姜5-10克,桂枝7-12克,麦冬5-15克,石菖蒲5-15克,泽泻10-20克,茵陈蒿10-15克,丹参7-12克,天花粉5-15克。
优选为:
灵芝草20克,太子参15克,百合15克,玉竹12克,益母草15克,龙眼肉15克,五味子9克,茉莉花10克,苦参15克,柏子仁12克,川芎15克,黄芪10克,甘松10克,黄精15克,酸枣仁12克,甘草15克,桑椹15克,当归10克,龙齿10克,南沙参9克,连翘10克,前胡9克,莲子心9克,半夏10克,干姜8克,桂枝9克,麦冬10克,石菖蒲10克,泽泻15克,茵陈蒿12克,丹参9克,天花粉10克。
本发明药物的制备方法如下:
一、备料
1、灵芝草:除去杂质,洗净,润软,切厚片,干燥,筛去碎屑;
2、太子参:摘除须根,晒干;
3、百合:拣去杂质,黑瓣,簸除灰屑;
4、玉竹:除去杂质,洗净泥土,闷润至内外湿度均匀,切片,晒干;
5、益母草:拣去杂质,洗净,润透,切段,晒干;
6、龙眼肉:取原药材,除去杂质;
7、五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
8、茉莉花:拣去杂质,晒干;
9、苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干;
10、柏子仁:拣净杂质,除去残留的外壳和种皮;
11、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
12、黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
13、甘松:除净杂质,抢水速洗,捞出,切段,晾干;
14、黄精:洗净泥土,略润,切片,晒干;
15、酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将刺仁捞出,晒干;
16、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
17、桑椹:用水洗净,拣去杂质,摘除长柄,晒干;
18、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
19、龙齿:刷净泥土,打碎;
20、南沙参:除去须根,洗净,刮去粗皮,干燥;
21、连翘:拣净杂质,搓开,除去枝梗;
22、前胡:取原药材,除去杂质,洗净,润透,切薄片,干燥或低温干燥,筛去碎屑;
23、莲子心:秋季采收莲子时,从莲子中剥取,晒干;
24、半夏:拣去杂质,筛去灰屑;
25、干姜:拣净杂质,用水浸泡3—6小时,捞出,闷润后切片或切成小方块,晒干;
26、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
27、麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
28、石菖蒲:拣去杂质,洗净,稍稍浸泡,润透,切片,晒干;
29、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
30、茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥屑;
31、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
32、天花粉:拣去杂质,大小块分开,用水泡约六成透,捞出,闷润至内外湿度均匀,切片,晒干,或用水洗净,捞出,晒至极干,捣成小块。
二、制备
1、将炮制后的灵芝草、太子参、百合、玉竹、益母草、龙眼肉、五味子、茉莉花、苦参、柏子仁、川芎、黄芪、甘松、黄精、酸枣仁、甘草、桑椹、当归、龙齿、南沙参、连翘、前胡、莲子心、半夏、干姜、桂枝、麦冬、石菖蒲、泽泻、茵陈蒿、丹参、天花粉放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中麦冬有养阴润肺,清心除烦,益胃生津的功能为君药;太子参补肺、健脾;酸枣仁有养肝,宁心,安神的功能,二者为臣药,三味药共同发挥养阴润肺,清心除烦,益胃生津,补肺、健脾,宁心安神的作用,治疗心悸病效力全面,且以补肺健脾,清心除烦,宁心安神为主可治本,龙眼肉有益心脾,补气血,安神的功能为佐药,灵芝草有补气安神,治眩晕不眠,心悸气短的功能为使药,与余下诸药是治标。
本发明药物具有清心除烦,益胃生津,宁心安神,补肺健脾,益心脾,补气血的功能,用于治疗心悸病,疗程短、见效快、治愈后不复发。
具体实施方式:
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治心悸病门诊患者共33例。
2、诊断标准
典型症状为患者心情紧张,忧心忡忡,感觉疲倦,呼吸困难,心律失常,严重者会导致晕厥或抽搐和出现甲亢等症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:心悸病症状消失,体质恢复正常,痊愈;
好转:患者心慌,疲倦,呼吸困难,心律失常的症状减轻,心悸病症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗心悸病患者33例,结果显效25例,显效率为75.75%,好转5例,好转率为15.15%,无效3例,总有效率为90.9%。
Claims (3)
1.一种治疗心悸病的药物,其特征在于:它是由下列重量范围内的原料药制成:
灵芝草15-25克,太子参10-20克,百合10-20克,玉竹10-15克,益母草10-20克,龙眼肉10-20克,五味子7-12克,茉莉花5-15克,苦参10-20克,柏子仁10-15克,川芎10-20克,黄芪5-15克,甘松5-15克,黄精10-20克,酸枣仁10-15克,甘草10-20克,桑椹10-20克,当归5-15克,龙齿5-15克,南沙参7-12克,连翘5-15克,前胡7-12克,莲子心7-12克,半夏5-15克,干姜5-10克,桂枝7-12克,麦冬5-15克,石菖蒲5-15克,泽泻10-20克,茵陈蒿10-15克,丹参7-12克,天花粉5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
灵芝草20克,太子参15克,百合15克,玉竹12克,益母草15克,龙眼肉15克,五味子9克,茉莉花10克,苦参15克,柏子仁12克,川芎15克,黄芪10克,甘松10克,黄精15克,酸枣仁12克,甘草15克,桑椹15克,当归10克,龙齿10克,南沙参9克,连翘10克,前胡9克,莲子心9克,半夏10克,干姜8克,桂枝9克,麦冬10克,石菖蒲10克,泽泻15克,茵陈蒿12克,丹参9克,天花粉10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)灵芝草:除去杂质,洗净,润软,切厚片,干燥,筛去碎屑;
(2)太子参:摘除须根,晒干;
(3)百合:拣去杂质,黑瓣,簸除灰屑;
(4)玉竹:除去杂质,洗净泥土,闷润至内外湿度均匀,切片,晒干;
(5)益母草:拣去杂质,洗净,润透,切段,晒干;
(6)龙眼肉:取原药材,除去杂质;
(7)五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
(8)茉莉花:拣去杂质,晒干;
(9)苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干;
(10)柏子仁:拣净杂质,除去残留的外壳和种皮;
(11)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(12)黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
(13)甘松:除净杂质,抢水速洗,捞出,切段,晾干;
(14)黄精:洗净泥土,略润,切片,晒干;
(15)酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将刺仁捞出,晒干;
(16)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
(17)桑椹:用水洗净,拣去杂质,摘除长柄,晒干;
(18)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(19)龙齿:刷净泥土,打碎;
(20)南沙参:除去须根,洗净,刮去粗皮,干燥;
(21)连翘:拣净杂质,搓开,除去枝梗;
(22)前胡:取原药材,除去杂质,洗净,润透,切薄片,干燥或低温干燥,筛去碎屑;
(23)莲子心:秋季采收莲子时,从莲子中剥取,晒干;
(24)半夏:拣去杂质,筛去灰屑;
(25)干姜:拣净杂质,用水浸泡3—6小时,捞出,闷润后切片或切成小方块,晒干;
(26)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(27)麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
(28)石菖蒲:拣去杂质,洗净,稍稍浸泡,润透,切片,晒干;
(29)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(30)茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥屑;
(31)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(32)天花粉:拣去杂质,大小块分开,用水泡约六成透,捞出,闷润至内外湿度均匀,切片,晒干,或用水洗净,捞出,晒至极干,捣成小块;
(二)制备
(1)将炮制后的灵芝草、太子参、百合、玉竹、益母草、龙眼肉、五味子、茉莉花、苦参、柏子仁、川芎、黄芪、甘松、黄精、酸枣仁、甘草、桑椹、当归、龙齿、南沙参、连翘、前胡、莲子心、半夏、干姜、桂枝、麦冬、石菖蒲、泽泻、茵陈蒿、丹参、天花粉放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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