CN105920545A - 一种治疗乳腺增生的中药组合物及其制备方法 - Google Patents
一种治疗乳腺增生的中药组合物及其制备方法 Download PDFInfo
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Abstract
一种治疗乳腺增生的中药组合物及其制备方法，属于中药医学技术领域，所述治疗乳腺增生的中药组合物，由下述重量配比的原料制成：蒲公英2500—3500g、夏枯草2500—3500g、牡蛎2500—3500g、皂针800—1200g、赤芍800—1200g、青皮800—1200g、三棱800—1200g、橘核800—1200g、文术800—1200g、蚤休800—1200g、橘叶800—1200g、桃仁800—1200g、当归1500‑2500g、天龙800—1200g、鳖甲800—1200g、姜虫800—1200g。本发明标本兼治、无毒副作用、使用方便、成本低。
Description
技术领域
本发明属于中药医学技术领域，具体涉及一种治疗乳腺增生的中药组合物及其制备方法。
背景技术
乳腺增生是女性常见的乳腺疾病，其发病率占乳腺疾病的首位，多发于30-50岁女性，发病高峰为35-40岁。其又名小叶增生，是指乳腺上皮和纤维组织增生，乳腺组织导管和乳小叶在结构上的退行性病变及进行性***的生长，其发病原因主要是内分泌激素失调。乳腺增生的早期表现症状有：1、***疼痛：常为胀痛或刺痛，可累及一侧或两侧***，以一侧偏重多见，疼痛严重者不可触碰，甚至影响日常生活及工作，疼痛以***肿块处为主，亦可向患侧腋窝，胸胁或肩背部放射；有些则表现为***疼痛或痒，***疼痛常于月经前数天出现或加重，行经后疼痛明显减轻或消失；疼痛亦可随情绪变化而波动，这种与***及情绪变化有关的疼痛是乳腺增生临床表现的主要特点；2、***肿块：肿块可发于单侧或双侧***内，单个或多个，好发于***外上象限，亦可见于其他象限，肿块形状有片块状、结节状、条索状、颗粒状等，其中以片块状为多见，肿块边界不明显，质地中等或稍硬韧，活动好，与周围组织无粘连，常有触痛，肿块大小不一，小者如粟粒般大，大者可逾3～4cm，***肿块也有随***而变化的特点，月经前肿块增大***，月经来潮后肿块缩小***。乳腺增生有很多类型：生理性的乳腺增生，如单纯性乳腺增生症，不需特殊处理，可自行消退。因为精神、情绪及人为因素引起的乳腺增生，通过自身的调整(如及时诊治与乳腺疾病发生相关的其它器官疾病，调节情绪、缓解精神压力，改变不健康的饮食习惯，戒烟戒酒等)也会消退或缓解；病理性的乳腺增生，需积极治疗，尤其是囊性增生类型，由于存在癌变的可能，不能掉以轻心。临床上常用的药物多数是中成药，但治疗时间长，不能根治，效果不佳。此外，尚有激素疗法，有人采用雄激素治疗本病，但这种治疗有可能加剧人体激素间失衡，不宜常规应用。
发明内容
本发明的目的在于克服现有乳腺增生治疗中存在的缺陷，提供一种标本兼治、无毒副作用、使用方便的治疗乳腺增生的中药组合物及其制备方法。
一种治疗乳腺增生的中药组合物，由下述重量配比的原料制成：蒲公英2500—3500g、夏枯草2500—3500g、牡蛎2500—3500g、皂针800—1200g、赤芍800—1200g、青皮800—1200g、三棱800—1200g、橘核800—1200g、文术800—1200g、蚤休800—1200g、橘叶800—1200g、桃仁800—1200g、当归1500-2500g、天龙800—1200g 、鳖甲800—1200g、姜虫800—1200g。
所述一种治疗乳腺增生的中药组合物的制备方法，包括以下步骤：（1）按比例取蒲公英、夏枯草、牡蛎、皂针、赤芍、青皮、三棱、橘核、文术、蚤休、橘叶、桃仁、当归共十三味药材，加水煎煮2-4次，合并药液再次煎煮至呈浸膏状，后烘干，再粉碎成细粉，备用；（2）按比例取天龙、鳖甲、姜虫，粉碎细粉，后与步骤（1）所得产物混合均匀，制成蜜丸，即得本发明中药组合物。
本发明的组方方义：
蒲公英：甘、微苦，寒。功用：清热解毒、消肿散结。
夏枯草：味甘、辛、微苦，性寒。功用：散结消肿、清热解毒。
牡蛎：咸，微寒。归肝、胆、肾经。功用：平肝息风、软坚散结。
皂针：辛，温。入肝、肺经。功能：消肿托毒、排脓、杀虫。
赤芍：酸、苦，微寒。入肝经。功用：散瘀活血、止痛。
青皮：苦、辛，性温。归肝、胆、胃经。功能：疏肝理气、消积化滞。
三棱：味辛、涩，凉。入肝、脾经。功能：软坚散结、通乳络消核，治胁肋胀痛，痛经，闭经，疮肿坚硬。
橘核：苦，平。归肝、肾经。功能：理气、散结、止痛，用于乳痈肿痛。
文术：苦、辛、温。归肝、脾、胃、大肠、肺经。功能：败毒抗癌、破淤消肿、行滞缓痛。
蚤休：味苦，微寒。入心、肝经。功能：清热解毒，治痈肿、疔疮。
橘叶：苦，平。功能：疏肝、行气、化痰、消肿毒，治胁痛，乳痈，肺痈。
桃仁：味苦、甘，性平。入心、肝、大肠经。功能：活血祛瘀。
当归：味甘、辛、苦，性温。归肝、心、脾经。功能：活血化瘀、调经止痛。
天龙：辛，温。归肝经。功能: 息风镇痉、功毒散结、通络止痛。
鳖甲：咸、寒。归肝、肾经。功能：软坚散结、退热除蒸。
姜虫：辛咸，平。入肝经、肺经，胃经。功能：祛风解痉，化痰散结。
有益效果
本发明的有益效果在于，标本兼治、无毒副作用、使用方便、成本低。
具体实施方式
通过以下实施例进一步举例描述本发明，并不以任何方式限制本发明，在不背离本发明的技术解决方案的前提下，对本发明所作的本领域普通技术人员容易实现的任何改动或改变都将落入本发明的权利要求范围之内。
实施例1
一种治疗乳腺增生的中药组合物，由下述重量配比的原料制成：蒲公英2500g、夏枯草2500g、牡蛎2500g、皂针800g、赤芍800g、青皮800g、三棱800g、橘核800g、文术800g、蚤休800g、橘叶800g、桃仁800g、当归1500g、天龙800g、鳖甲800g、姜虫800g。
实施例2
一种治疗乳腺增生的中药组合物，由下述重量配比的原料制成：蒲公英3000g、夏枯草3000g、牡蛎3000g、皂针1000g、赤芍1000g、青皮1000g、三棱1000g、橘核1000g、文术1000g、蚤休1000g、橘叶1000g、桃仁1000g、当归2000g、天龙1000g、鳖甲1000g、姜虫1000g。
实施例3
一种治疗乳腺增生的中药组合物，由下述重量配比的原料制成：蒲公英3500g、夏枯草3500g、牡蛎3500g、皂针1200g、赤芍1200g、青皮1200g、三棱1200g、橘核1200g、文术1200g、蚤休1200g、橘叶1200g、桃仁1200g、当归2500g、天龙1200g、鳖甲1200g、姜虫1200g。
上述一种治疗乳腺增生的中药组合物的制备方法，包括以下步骤：
（1）按比例取蒲公英、夏枯草、牡蛎、皂针、赤芍、青皮、三棱、橘核、文术、蚤休、橘叶、桃仁、当归共十三味药材，加水煎煮3次，合并药液再次煎煮至呈浸膏状，后烘干，再粉碎成细粉；
（2）按比例取天龙、鳖甲、姜虫，粉碎细粉，后与步骤（1）所得产物混合均匀，按照本领域常规技术制成蜜丸，每丸重约9g。
服用方法：每次服用一丸，每日两次，黄酒为引，温开水送服。
采用本发明中药组合物应用乳腺增生患者临床试验：
经100例乳腺增生患者临床试验，其中年龄最大者65岁，最小者24岁。
诊断标准：***有结块，且局部肿、热、痛，并伴有高热、头痛等症状。
临床试验结果：实验患者共计100例，痊愈90例，有效7例，无效3例，有效率97%。
根据国家中医药管理局发布的《中医病症诊断疗效标准》：
痊愈：***肿块、痛疼消失，同时高热、头痛等症状也消失；
有效：***肿块缩小，痛疼减轻或消失，同时高热、头痛等症状消失；
无效：***肿块与痛疼无变化。
以下通过典型病例对本发明中药组合物对乳腺增生治疗的疗效作进一步说明。
典型病例
1、李某，女，34岁，自述：两***胀痛，右侧为重，有时痛至腋窝或肩背部，***疼痛常于月经前数天出现或加重，行经后疼痛减轻，亦随情绪、劳累变化而波动，给与本发明实施例1予以治疗，每次一丸，每日两次，服药三天，症状明显减轻，服药一个月痊愈。
2、刘某，女，40岁，自述：左侧***疼痛一年余，诊见：能触摸到条索状肿物，有触痛，边界不明显，质地稍硬，伴有高热，给予本发明实施例2予以治疗，每次一丸，每日两次，服药7天后，疼痛减轻，肿块稍软，服药20日痊愈。
3、王某，女，37岁，自述：家庭生活矛盾较多，经常生气，两***胀痛有两周，且有头痛，尤其是生气的时候，疼痛加重，给予本发明实施例1给予治疗，每次一丸，每日两次，服药4天后，疼痛减轻，服药10日痊愈。
4、乔某，女，45岁，自述：右侧***疼痛三个月，诊见：肿块，边界不明显，质地稍硬，给予本发明实施例3给予治疗，每次一丸，每日两次，服药7天后，疼痛减轻，服药一个月痊愈。
本发明药物诸药合成，相得益彰，有清热解毒、疏肝理气生、化痰清淤、软坚散结之功效，因此本发明对治疗乳腺增生有显著疗效。
Claims (2)
1.一种治疗乳腺增生的中药组合物，其特征在于：由下述重量配比的原料制成：蒲公英2500—3500g、夏枯草2500—3500g、牡蛎2500—3500g、皂针800—1200g、赤芍800—1200g、青皮800—1200g、三棱800—1200g、橘核800—1200g、文术800—1200g、蚤休800—1200g、橘叶800—1200g、桃仁800—1200g、当归1500-2500g、天龙800—1200g、鳖甲800—1200g、姜虫800—1200g。
2.如权利要求1所述的一种治疗乳腺增生的中药组合物的制备方法，其特征在于：包括以下步骤：
（1）按比例取蒲公英、夏枯草、牡蛎、皂针、赤芍、青皮、三棱、橘核、文术、蚤休、橘叶、桃仁、当归共十三味药材，加水煎煮2-4次，合并药液再次煎煮至呈浸膏状，后烘干，再粉碎成细粉，备用；
（2）按比例取天龙、鳖甲、姜虫，粉碎细粉，后与步骤（1）所得产物混合均匀，制成蜜丸，即得本发明中药组合物。
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