CN105902642A - Pharmaceutical composition having breast health care function, and preparation method and use of pharmaceutical composition - Google Patents

Pharmaceutical composition having breast health care function, and preparation method and use of pharmaceutical composition Download PDF

Info

Publication number
CN105902642A
CN105902642A CN201610475008.2A CN201610475008A CN105902642A CN 105902642 A CN105902642 A CN 105902642A CN 201610475008 A CN201610475008 A CN 201610475008A CN 105902642 A CN105902642 A CN 105902642A
Authority
CN
China
Prior art keywords
weight portion
pharmaceutical composition
weight
preparation
olibanum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610475008.2A
Other languages
Chinese (zh)
Inventor
马月鲤
杨跃华
冯治聪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610475008.2A priority Critical patent/CN105902642A/en
Publication of CN105902642A publication Critical patent/CN105902642A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732Chaenomeles, e.g. flowering quince
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Animal Husbandry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a pharmaceutical composition having a breast health care function, and a preparation method and use of the pharmaceutical composition. The pharmaceutical composition comprises the following active pharmaceutical ingredients: 5-15 parts by weight of fructus chaenomelis, 1-10 parts by weight of radix angelicae sinensis, 1-9 parts by weight of safflower, 1-9 parts by weight of herba leonuri, 0.5-8 parts by weight of caulis spatholobi, 3-12 parts by weight of semen persicae, 0.5-8 parts by weight of frankincense, 0.5-8 parts by weight of myrrh and 0.1-5 parts by weight of squama manitis. The pharmaceutical composition fully considers the channel tropism, properties and flavor of all the traditional Chinese medicines, and selects the ratio among the traditional Chinese medicines so as to enable the traditional Chinese medicines to cooperate with one another in a compatibility relation of 'monarch, minister, adjuvant and envoy' for realizing combined action, therefore, the pharmaceutical composition has the breast health care function.

Description

A kind of pharmaceutical composition with breast health promotion effect and preparation method thereof and purposes
Technical field
The invention belongs to medicine or field of health care products, be specifically related to a kind of medicine with breast health promotion effect Compositions and preparation method thereof and purposes.
Background technology
Breast is the vitals of female body, is also to embody the significant points that women limbs are beautiful.Along with year The growth in age, the problem of female breast the most gradually highlights, cyclomastopathy, mammary gland fibroma, mammary gland All kinds of mastopathy such as the breast caking that scorching, tuberculosis of breast causes have had a strong impact on the Health and Living of women.
Chinese patent literature CN1291506A discloses the mastotic external used medicine of a kind of preventing and treating, by following The unguentum that the crude drug of proportioning is made: Colla cornus cervi 0.1-0.25g, Moschus 0.01-0.02g, Squama Manis 0.3- 0.52g, Spica Prunellae 0.4-0.6g, sky fourth 0.05-0.10g, Radix Angelicae Sinensis 0.15-0.25g, Oleum Ricini 0.3-0.6g, Vaseline 0.3-0.6g, Fructus Trichosanthis 0.15-0.25g, Colophonium 1.0-1.5g, Camphora 0.2-0.5g, zinc oxide 0.1- 0.2g, Herba Taraxaci 0.3-0.6g etc., but, there is composition complexity, cost relatively in above-mentioned Chinese medicine composition The shortcomings such as height, thus limit its application.
Therefore, study that novel therapeutic effect is good, toxic and side effects is little, it is simple to form, lower-cost tool The medicine having breast health promotion effect is significant.
Summary of the invention
To this end, the present invention propose a kind of pharmaceutical composition with breast health promotion effect and preparation method thereof with Purposes.
For solving above-mentioned technical problem, the present invention is achieved through the following technical solutions:
The present invention provides a kind of pharmaceutical composition with breast health promotion effect, its crude drug composition to include:
Fructus Chaenomelis 5-15 weight portion, Radix Angelicae Sinensis 1-10 weight portion, Flos Carthami 1-9 weight portion, Herba Leonuri 1-9 weight portion, Caulis Spatholobi 0.5-8 weight portion, Semen Persicae 3-12 weight portion, Olibanum 0.5-8 weight portion, Myrrha 0.5-8 weight portion, Squama Manis 0.1-5 weight portion.
Preferably, the above-mentioned pharmaceutical composition with breast health promotion effect of the present invention, its crude drug composition bag Include:
Fructus Chaenomelis 8-10 weight portion, Radix Angelicae Sinensis 4-6 weight portion, Flos Carthami 3-5 weight portion, Herba Leonuri 3-5 weight portion, Caulis Spatholobi 2-4 weight portion, Semen Persicae 5-7 weight portion, Olibanum 2-4 weight portion, Myrrha 2-4 weight portion, Squama Manis 1-2 weight portion.
It is further preferred that the above-mentioned pharmaceutical composition with breast health promotion effect of the present invention, its crude drug Composition includes:
Fructus Chaenomelis 8 weight portion, Radix Angelicae Sinensis 6 weight portion, Flos Carthami 3 weight portion, Herba Leonuri 5 weight portion, Caulis Spatholobi 2 Weight portion, Semen Persicae 7 weight portion, Olibanum 2 weight portion, Myrrha 4 weight portion, Squama Manis 1 weight portion;Or
Fructus Chaenomelis 10 weight portion, Radix Angelicae Sinensis 4 weight portion, Flos Carthami 5 weight portion, Herba Leonuri 3 weight portion, Caulis Spatholobi 4 Weight portion, Semen Persicae 5 weight portion, Olibanum 4 weight portion, Myrrha 2 weight portion, Squama Manis 2 weight portion;Or
Fructus Chaenomelis 9 weight portion, Radix Angelicae Sinensis 5 weight portion, Flos Carthami 4 weight portion, Herba Leonuri 4 weight portion, Caulis Spatholobi 3 Weight portion, Semen Persicae 6 weight portion, Olibanum 3 weight portion, Myrrha 3 weight portion, Squama Manis 1.5 weight portion;Or Person
Fructus Chaenomelis 8.5 weight portion, Radix Angelicae Sinensis 5.5 weight portion, Flos Carthami 4.5 weight portion, Herba Leonuri 3.5 weight portion, chicken Caulis seu Radix Schisandrae Henryi 2.5 weight portion, Semen Persicae 6.5 weight portion, Olibanum 2.5 weight portion, Myrrha 3.5 weight portion, Squama Manis 1.5 Weight portion.
It is further preferred that the above-mentioned pharmaceutical composition with breast health promotion effect of the present invention, its crude drug Composition also includes: Mel 0.05-0.5 weight portion.
It is further preferred that the above-mentioned pharmaceutical composition with breast health promotion effect of the present invention, its crude drug Composition also includes: Mel 0.1-0.3 weight portion.
It is further preferred that the above-mentioned pharmaceutical composition with breast health promotion effect of the present invention, its crude drug Composition also includes: Mel 0.1,0.2 or 0.3 weight portion.
The present invention also provides for the preparation method of the above-mentioned pharmaceutical composition with breast health promotion effect, including with Lower step:
Take the Fructus Chaenomelis of selected weight portion, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, do not have Medicine and Squama Manis, add water 40-100 DEG C and extract at least 1 time, add the water extraction of at least 2 weight times amount every time At least 0.5 hour, filtering, merging filtrate, being concentrated into relative density at 50 DEG C is the clear paste of 1.00-1.30, Obtain.
Preferably, the preparation method of the above-mentioned pharmaceutical composition with breast health promotion effect of the present invention, including Following steps:
Take the Fructus Chaenomelis of selected weight portion, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, do not have Medicine and Squama Manis, add water 60-100 DEG C and extract 1-2 time, and the water extraction 2-4 every time adding 8-20 weight times amount is little Time, filtering, merging filtrate, being concentrated into relative density at 50 DEG C is the clear paste of 1.00-1.30, to obtain final product.
The present invention also provides for the preparation method of the above-mentioned pharmaceutical composition with breast health promotion effect, including with Lower step:
Take the Fructus Chaenomelis of selected weight portion, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, do not have Medicine and Squama Manis, add water 40-100 DEG C and extract at least 1 time, add the water extraction of at least 2 weight times amount every time At least 0.5 hour, filtering, merging filtrate, being concentrated into relative density at 50 DEG C is the clear paste of 1.00-1.30, It is subsequently adding the Mel of selected weight portion, stirring, mix homogeneously, to obtain final product.
Preferably, the preparation method of the above-mentioned pharmaceutical composition with breast health promotion effect of the present invention, including Following steps:
Take the Fructus Chaenomelis of selected weight portion, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, do not have Medicine and Squama Manis, add water 60-100 DEG C and extract 1-2 time, and the water extraction 2-4 every time adding 8-20 weight times amount is little Time, filtering, merging filtrate, being concentrated into relative density at 50 DEG C is the clear paste of 1.00-1.30, is subsequently adding The Mel of selected weight portion, stirring, mix homogeneously, to obtain final product.
The present invention also provides for including the preparation of aforementioned pharmaceutical compositions or including prepared by above-mentioned preparation method The preparation of the pharmaceutical composition obtained,
Described pharmaceutical composition adds customary adjuvant, according to common process, makes the most acceptable Agent, capsule, powder, mixture, pill, granule, solution, syrup, soft extract, beverage, Cookies, confection, cake or patch.
Described customary adjuvant is: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, Correctives, preservative, substrate etc..Filler includes: starch, pregelatinized Starch, lactose, mannitol, Chitin, microcrystalline Cellulose, sucrose etc.;Disintegrating agent includes: starch, pregelatinized Starch, microcrystalline cellulose Element, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl Cellulose is received;Lubricant includes: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide Deng;Suspending agent includes: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl methyl Cellulose etc.;Binding agent includes, starch slurry, polyvinylpyrrolidone, hydroxypropyl methyl cellulose etc.; Sweeting agent includes: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.;Correctives includes: Sweeting agent and various essence;Preservative includes: parabens, benzoic acid, sodium benzoate, sorbic acid and Its esters, benzalkonium bromide, acetic acid chloroethene are fixed, eucalyptus oil etc.;Substrate includes: PEG6000, PEG4000, insect wax etc..
The present invention also provides for aforementioned pharmaceutical compositions, above-mentioned preparation method prepares pharmaceutical composition,
Or the application that the preparation of aforementioned pharmaceutical compositions is in preparing the medicine or health product with breast health promotion effect.
Compared with prior art, the technique scheme of the present invention has the advantage that
[Fructus Chaenomelis] is warm in nature, sour in the mouth, return Liver Channel, spleen channel, has and helps digestion, lactogenic, heat clearing away, dispels the wind Effect.
[Radix Angelicae Sinensis] is warm in nature, sweet in the mouth, pungent, returns Liver Channel, heart channel, spleen channel, has promoting blood circulation and stopping pain, enriches blood Regulating menstruation, effect of loosening bowel to relieve constipation.
[Flos Carthami] is warm in nature, acrid in the mouth, GUIXIN warp, Liver Channel, the effect have activating blood circulation to dissipate blood stasis, stimulating the menstrual flow.
[Herba Leonuri] cold nature, acrid in the mouth, bitter in the mouth, GUIXIN warp, Liver Channel, bladder warp, there is invigorating blood circulation Silt, effect of inducing diuresis to remove edema.
[Caulis Spatholobi] is warm in nature, bitter in the mouth, micro-sweet, returns Liver Channel, has the merit of blood circulation promoting and enriching, relaxing muscles and tendons and activating QI and blood in the collateral Effect.
[Semen Persicae] property put down, bitter in the mouth, GUIXIN warp, Liver Channel, lung meridian, large intestine channel, have activating blood and removing stasis, Effect of loosening bowel to relieve constipation.
[Olibanum] is warm in nature, acrid in the mouth, hardship, GUIXIN warp, Liver Channel, spleen channel, has promoting blood circulation and stopping pain, detumescence Effect of granulation promoting.
[Myrrha] property is put down, bitter in the mouth, and GUIXIN warp, Liver Channel, spleen channel have promoting blood circulation and stopping pain, detumescence and promoting granulation Effect.
[Squama Manis] cold nature, salty in the mouth, return Liver Channel, stomach warp, there is promoting blood circulation to restore menstrual flow, stimulating milk secretion, detumescence Effect of evacuation of pus.
(1) pharmaceutical composition of the present invention, take into full account each Chinese medicine return through and nature and flavor, and select Each Chinese medicine proportioning each other, makes each Chinese medicine mutual according to the compatibility relationship of " monarch, minister, help, make " Coordinate, jointly act on, thus play the effect of breast health promotion;
(2) compositions of the present invention, not only has significant breast health promotion effect, and poison pair is made With less, safety is higher;
(3) compositions of the present invention, only includes nine kinds of crude drug, and composition is simple, cost is relatively low.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, being embodied as below according to the present invention Example also combines accompanying drawing, and the present invention is further detailed explanation, wherein:
Fig. 1 is the newborn pad pasting in the embodiment of the present invention 3;
Fig. 2 is the newborn pad pasting in the embodiment of the present invention 4;
Fig. 3 is the newborn pad pasting in the embodiment of the present invention 5.
Detailed description of the invention
Embodiment 1
The present embodiment has the pharmaceutical composition of breast health promotion effect, and its crude drug consists of: Fructus Chaenomelis 8g, Radix Angelicae Sinensis 6g, Flos Carthami 3g, Herba Leonuri 5g, Caulis Spatholobi 2g, Semen Persicae 7g, Olibanum 2g, Myrrha 4g, Squama Manis 1g;
Its preparation method, comprises the following steps: take the Fructus Chaenomelis of selected weight, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, Myrrha and Squama Manis, add water 60 DEG C and extract 2 times, adds 8 times of weight every time The water extraction of amount 4 hours, filters, and merging filtrate, being concentrated into relative density at 50 DEG C is the clear of 1.00-1.30 Cream, to obtain final product.
The present embodiment has the pharmaceutical composition of breast health promotion effect, adds customary adjuvant, according to conventional work Skill, makes soft extract.
Embodiment 2
The present embodiment has the pharmaceutical composition of breast health promotion effect, and its crude drug consists of: Fructus Chaenomelis 10g, Radix Angelicae Sinensis 4g, Flos Carthami 5g, Herba Leonuri 3g, Caulis Spatholobi 4g, Semen Persicae 5g, Olibanum 4g, Myrrha 2g, Squama Manis 2g;
Its preparation method, comprises the following steps: take the Fructus Chaenomelis of selected weight, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, Myrrha and Squama Manis, add water 100 DEG C and extract 1 time, adds 20 weight times amount Water extraction 2 hours, filter, merging filtrate, being concentrated into relative density at 50 DEG C is the clear paste of 1.00-1.30, Obtain.
The present embodiment has the pharmaceutical composition of breast health promotion effect, adds customary adjuvant, according to conventional work Skill, makes solution.
Embodiment 3
The present embodiment has the pharmaceutical composition of breast health promotion effect, and its crude drug consists of: Fructus Chaenomelis 9g, Radix Angelicae Sinensis 5g, Flos Carthami 4g, Herba Leonuri 4g, Caulis Spatholobi 3g, Semen Persicae 6g, Olibanum 3g, Myrrha 3g, Squama Manis 1.5g, Mel 0.2g;
Its preparation method, comprises the following steps: take the Fructus Chaenomelis of selected weight, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, Myrrha and Squama Manis, add water 80 DEG C and extract 1 time, adds 14 weight times amount Water extraction 3 hours, filter, merging filtrate, being concentrated into relative density at 50 DEG C is the clear paste of 1.00-1.30, It is subsequently adding the Mel of selected weight, stirring, mix homogeneously, to obtain final product.
The present embodiment has the pharmaceutical composition of breast health promotion effect, adds customary adjuvant, and uniform application exists On non-woven fabrics, according to common process, make patch.As it is shown in figure 1, described patch is a diameter of D's Circular newborn pad pasting, it is provided centrally with the manhole of a diameter of d;Wherein, diameter D is 200mm, diameter d are 25mm.
Embodiment 4
The present embodiment has the pharmaceutical composition of breast health promotion effect, and its crude drug consists of: Fructus Chaenomelis 8.5g, Radix Angelicae Sinensis 5.5g, Flos Carthami 4.5g, Herba Leonuri 3.5g, Caulis Spatholobi 2.5g, Semen Persicae 6.5g, Olibanum 2.5g, Myrrha 3.5g, Squama Manis 1.5g, Mel 0.3g;
Its preparation method, comprises the following steps: take the Fructus Chaenomelis of selected weight, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, Myrrha and Squama Manis, add water 70 DEG C and extract 2 times, adds 12 weight every time The water extraction of times amount 2.5 hours, filters, and merging filtrate, being concentrated into relative density at 50 DEG C is 1.00-1.30 Clear paste, be subsequently adding the Mel of selected weight, stirring, mix homogeneously, to obtain final product.
The present embodiment has the pharmaceutical composition of breast health promotion effect, adds facial film gel-type vehicle 5g, mixing Uniformly, add customary adjuvant, according to common process, make patch.As in figure 2 it is shown, described patch is The circular newborn pad pasting of a diameter of D, it is provided centrally with the manhole of a diameter of d, on breast pad pasting also It is provided with the circular mesh of several a diameter of d ';Wherein, diameter D is 240mm, and diameter d is 40mm, diameter d ' are 5-10mm.
Embodiment 5
The present embodiment has the pharmaceutical composition of breast health promotion effect, and its crude drug consists of: Fructus Chaenomelis 8g, Radix Angelicae Sinensis 6g, Flos Carthami 3g, Herba Leonuri 5g, Caulis Spatholobi 2g, Semen Persicae 7g, Olibanum 2g, Myrrha 4g, Squama Manis 1g, Mel 0.1g;
Its preparation method, comprises the following steps: take the Fructus Chaenomelis of selected weight, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, Myrrha and Squama Manis, add water 60 DEG C and extract 2 times, adds 8 times of weight every time The water extraction of amount 4 hours, filters, and merging filtrate, being concentrated into relative density at 50 DEG C is the clear of 1.00-1.30 Cream, is subsequently adding the Mel of selected weight, stirring, mix homogeneously, to obtain final product.
The present embodiment has the pharmaceutical composition of breast health promotion effect, adds facial film gel-type vehicle 10g, mixed Close uniformly, add customary adjuvant, according to common process, make patch.As it is shown on figure 3, described patch For the circular newborn pad pasting of a diameter of D, it is provided centrally with the manhole of a diameter of d, on breast pad pasting It is additionally provided with the foursquare mesh that several length of sides are d ';Diameter D is 220mm, and diameter d is 30mm;Length of side d ' it is 5-10mm.
Experimental example
Experimental example 1
Certain female, married, 30 years old, breast was lax, sagging;Adhere to using the breast of embodiment 3 preparation every day Pad pasting, without anaphylaxis, after using 6 months, breast become whitening skin, compact flexible, breast 1cm has been carried on before relatively using.
Experimental example 2
Certain female, married, 42 years old, breast relaxed, and cyclomastopathy, by being pressed with pain;Adhere to every day making With the newborn pad pasting of embodiment 4 preparation, without anaphylaxis during use, after using 2 months, breast becomes Must full compact, pain disappears, and in breast, lump substantially diminishes.
Experimental example 3
Certain female, 48 years old, married, cyclomastopathy, breast is by being pressed with lump, and pain is strong;Every day adheres to Use the newborn pad pasting of case study on implementation 5 preparation, react without any discomfort during use, after using 3 months, Breast lump softens, and pain substantially weakens.
Obviously, above-described embodiment is only for clearly demonstrating example, and not to embodiment Restriction.For those of ordinary skill in the field, can also do on the basis of the above description Go out change or the variation of other multi-form.Here without also cannot all of embodiment be given exhaustive. And the obvious change thus extended out or variation still in the protection domain of the invention among.

Claims (10)

1. a pharmaceutical composition, it is characterised in that its crude drug composition includes:
Fructus Chaenomelis 5-15 weight portion, Radix Angelicae Sinensis 1-10 weight portion, Flos Carthami 1-9 weight portion, Herba Leonuri 1-9 weight portion, Caulis Spatholobi 0.5-8 weight portion, Semen Persicae 3-12 weight portion, Olibanum 0.5-8 weight portion, Myrrha 0.5-8 weight portion, Squama Manis 0.1-5 weight portion.
Pharmaceutical composition the most according to claim 1, it is characterised in that its crude drug composition includes:
Fructus Chaenomelis 8-10 weight portion, Radix Angelicae Sinensis 4-6 weight portion, Flos Carthami 3-5 weight portion, Herba Leonuri 3-5 weight portion, Caulis Spatholobi 2-4 weight portion, Semen Persicae 5-7 weight portion, Olibanum 2-4 weight portion, Myrrha 2-4 weight portion, Squama Manis 1-2 weight portion.
Pharmaceutical composition the most according to claim 2, it is characterised in that its crude drug composition includes:
Fructus Chaenomelis 8 weight portion, Radix Angelicae Sinensis 6 weight portion, Flos Carthami 3 weight portion, Herba Leonuri 5 weight portion, Caulis Spatholobi 2 Weight portion, Semen Persicae 7 weight portion, Olibanum 2 weight portion, Myrrha 4 weight portion, Squama Manis 1 weight portion;Or
Fructus Chaenomelis 10 weight portion, Radix Angelicae Sinensis 4 weight portion, Flos Carthami 5 weight portion, Herba Leonuri 3 weight portion, Caulis Spatholobi 4 Weight portion, Semen Persicae 5 weight portion, Olibanum 4 weight portion, Myrrha 2 weight portion, Squama Manis 2 weight portion;Or
Fructus Chaenomelis 9 weight portion, Radix Angelicae Sinensis 5 weight portion, Flos Carthami 4 weight portion, Herba Leonuri 4 weight portion, Caulis Spatholobi 3 Weight portion, Semen Persicae 6 weight portion, Olibanum 3 weight portion, Myrrha 3 weight portion, Squama Manis 1.5 weight portion;Or Person
Fructus Chaenomelis 8.5 weight portion, Radix Angelicae Sinensis 5.5 weight portion, Flos Carthami 4.5 weight portion, Herba Leonuri 3.5 weight portion, chicken Caulis seu Radix Schisandrae Henryi 2.5 weight portion, Semen Persicae 6.5 weight portion, Olibanum 2.5 weight portion, Myrrha 3.5 weight portion, Squama Manis 1.5 Weight portion.
4. according to the pharmaceutical composition described in any one of claim 1-3, it is characterised in that its crude drug Composition also includes: Mel 0.05-0.5 weight portion.
5. the preparation method of the pharmaceutical composition described in an any one of claim 1-3, it is characterised in that Comprise the following steps:
Take the Fructus Chaenomelis of selected weight portion, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, do not have Medicine and Squama Manis, add water 40-100 DEG C and extract at least 1 time, add the water extraction of at least 2 weight times amount every time At least 0.5 hour, filtering, merging filtrate, being concentrated into relative density at 50 DEG C is the clear paste of 1.00-1.30, Obtain.
The preparation method of pharmaceutical composition the most according to claim 5, it is characterised in that include with Lower step:
Take the Fructus Chaenomelis of selected weight portion, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, do not have Medicine and Squama Manis, add water 60-100 DEG C and extract 1-2 time, and the water extraction 2-4 every time adding 8-20 weight times amount is little Time, filtering, merging filtrate, being concentrated into relative density at 50 DEG C is the clear paste of 1.00-1.30, to obtain final product.
7. the preparation method of the pharmaceutical composition described in a claim 4, it is characterised in that include with Lower step:
Take the Fructus Chaenomelis of selected weight portion, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, do not have Medicine and Squama Manis, add water 40-100 DEG C and extract at least 1 time, add the water extraction of at least 2 weight times amount every time At least 0.5 hour, filtering, merging filtrate, being concentrated into relative density at 50 DEG C is the clear paste of 1.00-1.30, It is subsequently adding the Mel of selected weight portion, stirring, mix homogeneously, to obtain final product.
The preparation method of pharmaceutical composition the most according to claim 7, it is characterised in that include with Lower step:
Take the Fructus Chaenomelis of selected weight portion, Radix Angelicae Sinensis, Flos Carthami, Herba Leonuri, Caulis Spatholobi, Semen Persicae, Olibanum, do not have Medicine and Squama Manis, add water 60-100 DEG C and extract 1-2 time, and the water extraction 2-4 every time adding 8-20 weight times amount is little Time, filtering, merging filtrate, being concentrated into relative density at 50 DEG C is the clear paste of 1.00-1.30, is subsequently adding The Mel of selected weight portion, stirring, mix homogeneously, to obtain final product.
9. include the preparation of the pharmaceutical composition described in any one of claim 1-4 or include that right is wanted Seek the preparation of the pharmaceutical composition that the preparation method described in any one of 5-8 prepares, it is characterised in that
Described pharmaceutical composition adds customary adjuvant, according to common process, makes the most acceptable Agent, capsule, powder, mixture, pill, granule, solution, syrup, soft extract, beverage, Cookies, confection, cake or patch.
10. described in pharmaceutical composition described in any one of claim 1-4, any one of claim 5-8 The preparation of the pharmaceutical composition described in pharmaceutical composition that preparation method prepares or claim 9 exists Preparation has the application in the medicine of breast health promotion effect or health product.
CN201610475008.2A 2016-06-24 2016-06-24 Pharmaceutical composition having breast health care function, and preparation method and use of pharmaceutical composition Pending CN105902642A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610475008.2A CN105902642A (en) 2016-06-24 2016-06-24 Pharmaceutical composition having breast health care function, and preparation method and use of pharmaceutical composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610475008.2A CN105902642A (en) 2016-06-24 2016-06-24 Pharmaceutical composition having breast health care function, and preparation method and use of pharmaceutical composition

Publications (1)

Publication Number Publication Date
CN105902642A true CN105902642A (en) 2016-08-31

Family

ID=56758662

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610475008.2A Pending CN105902642A (en) 2016-06-24 2016-06-24 Pharmaceutical composition having breast health care function, and preparation method and use of pharmaceutical composition

Country Status (1)

Country Link
CN (1) CN105902642A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111772251A (en) * 2020-08-10 2020-10-16 杜卓航 Functional bra and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101130034A (en) * 2007-09-24 2008-02-27 北京艺信堂医药研究所 Traditional Chinese medicine composition for treating gland hyperplasia
CN101518593A (en) * 2009-03-02 2009-09-02 张之霞 Traditional Chinese medicine composition for curing hyperplasia of mammary glands and resisting tumors and preparation method thereof
CN103933225A (en) * 2014-04-30 2014-07-23 翟峰 Instant medicine for treating hyperplasia of mammary glands and preparation method of instant medicine
CN104586716A (en) * 2013-10-31 2015-05-06 广州熹美生物科技有限公司 Breast nursing cream
CN104840904A (en) * 2015-06-12 2015-08-19 李兰珍 Traditional Chinese medicine composition for treating hyperplasia of mammary glands
CN105079969A (en) * 2015-08-14 2015-11-25 张航铭 Breast-care film with health-care function

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101130034A (en) * 2007-09-24 2008-02-27 北京艺信堂医药研究所 Traditional Chinese medicine composition for treating gland hyperplasia
CN101518593A (en) * 2009-03-02 2009-09-02 张之霞 Traditional Chinese medicine composition for curing hyperplasia of mammary glands and resisting tumors and preparation method thereof
CN104586716A (en) * 2013-10-31 2015-05-06 广州熹美生物科技有限公司 Breast nursing cream
CN103933225A (en) * 2014-04-30 2014-07-23 翟峰 Instant medicine for treating hyperplasia of mammary glands and preparation method of instant medicine
CN104840904A (en) * 2015-06-12 2015-08-19 李兰珍 Traditional Chinese medicine composition for treating hyperplasia of mammary glands
CN105079969A (en) * 2015-08-14 2015-11-25 张航铭 Breast-care film with health-care function

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111772251A (en) * 2020-08-10 2020-10-16 杜卓航 Functional bra and preparation method thereof

Similar Documents

Publication Publication Date Title
CN103285122A (en) Traditional Chinese medicine composition for treating swine mange and scab and preparation method thereof
CN105497496A (en) Traditional Chinese medicine composition with effect of improving male sexual functions and preparation method and application thereof
CN102552517A (en) Gynecological sugar-free gynaecopathia treating particle and preparation method thereof
CN103877247B (en) Medicine being used for the treatment of decubital ulcer and preparation method thereof
CN102228586B (en) Ointment for promoting union of bone fractures and preparation method thereof
CN1109554C (en) Medicine for treating allergic purpura
CN105902642A (en) Pharmaceutical composition having breast health care function, and preparation method and use of pharmaceutical composition
CN110339249A (en) A kind of Chinese medicine composition and its preparation method and application for hemorrhoid anal fissure
CN103611011B (en) A kind of medicine for the treatment of puerperal hypogalactia
CN101961452A (en) Method for preparing neck and waist rehabilitation medicinal plaster for treating osteoproliferation
CN101804153B (en) Lactagogue traditional Chinese medicine granules
WO2001064229A1 (en) A medicine for treating obesity and the method of producing thereof
CN102895577A (en) Traditional Chinese medicine composition for treating baby anorexia, and preparation and application method thereof
CN103417896A (en) Drug-addiction-stopping tea and preparation method thereof
CN102247486B (en) Bone health care marrow filling capsule
CN101049364B (en) Umbilicus pasted powder for eliminating hernia
CN105055685A (en) Ointment for treating chilblain and preparation method of ointment
CN2222542Y (en) Senility-proof health therapy band with kidney tonifying function
CN1985983A (en) Quick acting bone-knitting medicine and plaster and their preparing method
CN105853635A (en) Pharmaceutical composition for treating angina pectoris of coronary heart disease
CN106581578A (en) Pharmaceutical composition for body health care and preparation method of pharmaceutical composition
CN105362907A (en) Effervescent tablet for treating breast cyst and preparation method of effervescent tablet for treating breast cyst
CN105343858A (en) Spleen strengthening meridian warming and activating patch for child and extraction and forming process thereof
CN105477397A (en) Traditional Chinese medicine soft capsule for foot bath
CN102293862A (en) Traditional Chinese medicine preparation for treating impotence

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20160831

RJ01 Rejection of invention patent application after publication