CN105878286A - Veterinary drug for preventing and treating plague in poultry and preparation method of veterinary drug - Google Patents
Veterinary drug for preventing and treating plague in poultry and preparation method of veterinary drug Download PDFInfo
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- CN105878286A CN105878286A CN201510203750.3A CN201510203750A CN105878286A CN 105878286 A CN105878286 A CN 105878286A CN 201510203750 A CN201510203750 A CN 201510203750A CN 105878286 A CN105878286 A CN 105878286A
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- veterinary drug
- periplaneta americana
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Abstract
The invention discloses a veterinary drug for preventing and treating plague in poultry and a preparation method of the veterinary drug. The preparation method of the veterinary drug comprises the following steps: crushing dried or fresh periplaneta americana into powder or decocting the dried or fresh periplaneta americana with water, conducting concentrating, conducting ethanol precipitation, performing concentrating, conducting drying, mixing an obtained material with adjuvant materials and crushing an obtained mixture into powder so as to obtain powder. The veterinary drug disclosed by the invention has functions of resisting bacteria and resisting viruses, preventing plague and regulating immunity; and the veterinary drug is especially suitable for preventing and treating the plague in the poultry.
Description
Technical field
The invention belongs to veterinary drug field, be specifically related to a kind of for preventing and the veterinary drug treating poultry pestilence and preparation method thereof.
Background technology
Poultry pestilence will cause thousands of poultry dead every year, causes great economic loss, and scientist finds to cause the existing 15 kinds of HA and 9 kinds of NA of virus of poultry pestilence up to now.These virus some can also infect human body, human health is threatened.
Under society environmental condition, size epidemic disease feelings can constantly occur, during the most a large amount of use Western medicine are prevented and treated, the situation that following two is bad can occur: 1. the Western medicine of the overwhelming majority can form residual and savings in animal body, and people eat the livestock meat after slaughtering and can damage health；2. during life-time service Western medicine, animal is more prone to Drug resistance than human body, and the Drug resistance of animal is more powerful, occurring in that in a lot of rural areas or plant dose is more used the biggest, administration time is shorter and shorter, even every day will the situation of medication, medication various in style, to the crucial moment needing medication to treat, often Expected Results can not reach, cause substantial amounts of poultry dead, bring massive losses to raiser.
Fowl plague is typically to be caused by virus, and such as bird flu or Avian pneumo-encephalitis virus etc., its performance symptom is mainly (1) acute: morbidity is anxious, and the course of disease is short, beyond general performance lethargy,
Condition of illness without feature and sudden death.This type is more common in popular initial stage and chickling.(2) acute: sick just body temperature raises, typically subtracts food or useless food, yearningly drinks increase up to 43 44 DEG C.Lassitude, is reluctant to walk about, general weakness, and feather pine disorderly, closes mesh necking down, peels off slow-witted vertical, bradykinesia, sagging or put under wing, and tail feathers is sagging.Lower limb paresis.It is preced with in kermesinus or atropurpureus, accidental cephalledema.Oral cavity and nasal cavity secretions increase, outside permanent current outlet plenum or nasal cavity, sick chicken often shakes the head, action of constantly choking with sobs.Sick chicken dyspnea, peak with heading is dehisced to make respiratory movement, prolixity capsule flatulence, is amassed and have mucus.Often draw yellow, green and canescence
Stench loose stool.Lay eggs after hen is ill and decline rapidly or stop.Morbidity later stage temperature decline to below room temperature, i.e. death soon.Mortality rate is up to more than 90%.(3) subacute and chronic type.Duck pestilence (duck plague), also referred to as duck viral enteritis (duck virus enteritis), by duck enteritis virus (duck enteritis virus) or to claim duck plague virus (duck plague virus) or the duck claiming duck pestilence herpesvirus (duck plague herpesvirus) to cause, the one infectious disease acute, hot, septic of the Anseriformes birds such as goose, it is characterized in that blood vessel injury, organize hemorrhage, gastrointestinal mucosal is rotten to the corn, pathological changes occurs in lymphatic organ, organa parenchymatosum's degeneration.
In recent years, although having seen the report of some medicines about using Chinese herbal medicine that animal is prevented or to treat, but owing to past people for many years are less to the research of this respect, and what Chinese herbal medicine was taked is the dialectical conditioning means treated, and composition and the therapeutic effect of the most various prescriptions are different from.
Periplaneta americana (Periplanetaamericana L.) belongs to Insecta Blattaria Blattaria Blattidae Periplaneta, it is that in Blattidae, volume is maximum, also be in the world vitality the most by force, the most ancient, so far multiply one of most successful insect assembly, be commonly called as Blatta seu periplaneta, dish mother-in-law worm, steal oil mother-in-law.It is distributed mainly on indoor or the field of tropical and subtropical region, is one of a few Domestic Cockroaches kind, be indoor Dominant variety in southern area.
Periplaneta americana is traditional Chinese crude drug, often it is used as medicine with dry or fresh adult, its salty in the mouth cold in nature is poisonous, there is acid, have the functions such as dissipating blood stasis, removing food stagnancy, removing toxic substances, diuretic, detumescence, cure mainly infantile malnutrition, tonsillitis, health enclosed mass, ulcerative carbuncle swells and ache and Scolopendra bites.Research to periplaneta americana pharmacological action in recent years gets more and more, and its pharmaceutical preparation application clinically is more and more extensive.Modern pharmacological research periplaneta americana has the effect in terms of antitumor action, cardiovascular, promotes tissue repair, antibacterial, antivirus action, antioxidation, enhancing immunity, hepatoprotective effect, antiinflammatory, analgesic activity etc..
Summary of the invention
The technical problem to be solved in the present invention is: be directed to the deficiencies in the prior art, and the effect utilizing periplaneta americana to have antibacterial, antiviral and enhancing immunity provides a kind of veterinary drug that may be used for prevention and treatment poultry pestilence and preparation method thereof.
Thering is provided a kind of veterinary drug, its each weight ratio of constituents of described veterinary drug is for being dried American-cockroach-extract: adjuvant=1:0.5～2.
Further, its each weight ratio of constituents of described veterinary drug is for being dried American-cockroach-extract: adjuvant=1:1.
Thering is provided a kind of its each weight ratio of constituents of veterinary drug is periplaneta americana powder: adjuvant=1:0.5～2.
It is one or more that wherein said adjuvant is selected from dextrin, starch, Icing Sugar.
There is provided the preparation method of a kind of veterinary drug, it is characterised in that comprise the steps:
A, the dry worm of periplaneta americana add 6～the water of 12 times of crude drug amount volumes or the fresh worm of periplaneta americana adds 4～the soak by water of 8 times of crude drug amount volumes 2～4 times, decoct 0.5～2 hour every time and filter, filtrate is in 60 DEG C～80 DEG C of concentrating under reduced pressure, and concentrated solution, in 5 DEG C～15 DEG C of cold preservations 8～24 hours, removes upper strata oils and fats；
It is 50%～80% that b, concentrated solution step a obtained add ethanol alcohol to be sink to containing alcohol concentration, stand 8～24 hours, filter, filtrate is in 60 DEG C～80 DEG C of concentrating under reduced pressure, dried American-cockroach-extract mixes dozen powder with dextrin according to the ratio of 1:0.5～2, crosses 60～100 mesh sieves, and aluminium plastic bag is packed, 3～8g/ bags, last test package.
Further, the preparation method of veterinary drug, it is characterised in that comprise the steps:
A, dry for periplaneta americana worm will be separately added into 10 times, 8 times, 6 times or will be separately added into the water extraction 3 times of 6 times, 4 times, 4 times crude drug amount volumes in fresh for periplaneta americana worm, each 1 hour, filtrate is in 70 DEG C of concentrating under reduced pressure, and concentrated solution, in 10 DEG C of cold preservations 16 hours, removes upper strata oils and fats；
It is 70% that the concentrated solution that b, step a obtain add ethanol alcohol to be sink to containing alcohol concentration, stands 16 hours, filters, filtrate mixes dozen powder with dextrin according to the ratio of 1:1 in 70 DEG C of concentrating under reduced pressure, dried American-cockroach-extract, crosses 80 mesh sieves, aluminium plastic bag is packed, 3～8g/ bags, last test package.
Further described veterinary drug, it is characterised in that main component American-cockroach-extract and doxycycline hydrochloride weight ratio are 1:1.
Above-described veterinary drug, can add in feedstuff as feed additive and be used in conjunction with.
In sum, the veterinary drug prepared by preparation method of the present invention, prevention and treatment poultry pestilence curative effect achieve significant effect: total effective rate has 79% in the experimental result for the treatment of poultry pestilence, its effect and Doxycycline For The Treatment poultry pestilence effect are suitable, treat poultry pestilence and have the total effective rate of 94% after doxycycline drug combination；In preventive effect contrast experiment, veterinary drug of the present invention, compared with vaccine, has obvious preventive effect, and poultry sickness rate is about 1%.
Detailed description of the invention
Below in conjunction with specific embodiment, the detailed description of the invention of the present invention is described in detail:
Embodiment
1
Weigh periplaneta americana dry worm 1000g, be separately added into the soak by water three times of 10L, 8L, 6L, each 1 hour, filtering, filtrate is in 70 DEG C of concentrating under reduced pressure, and concentrated solution was in 10 DEG C of cold preservations 16 hours, after removing upper strata oils and fats, subnatant adds ethanol alcohol and is sink to containing alcohol concentration is 70%, stands 16 hours, filtering, filtrate mixes dozen powder with dextrin in the ratio of 1:1 in 70 DEG C of concentrating under reduced pressure, dried American-cockroach-extract, cross 80 mesh sieves, aluminium plastic bag is packed, 4g/ bag, last test package.
Embodiment
2
Weighing periplaneta americana fresh worm 1000g, cleaning, drying, be put in low-temperature grinding in pulverizer, then cross 80 mesh sieves, then mix in the ratio of 1:2 with starch, aluminium plastic bag is packed, 4g/ bag, last test package.
Embodiment
3
Weighing periplaneta americana dry worm 2000g, be separately added into the soak by water three times of 24L, 16L, 12L, each 2 hours, filter, filtrate is in 80 DEG C of concentrating under reduced pressure, and concentrated solution, in 15 DEG C of cold preservations 24 hours, removes upper strata oils and fats；It is 50% that concentrated solution add ethanol alcohol to be sink to containing alcohol concentration, stands 24 hours, filters, filtrate is dried in 60 DEG C of concentrating under reduced pressure, and dried American-cockroach-extract beats powder with dextrin in the ratio of 1:0.5, crosses 60 mesh sieves, aluminium plastic bag is packed, 4g/ bag, last test package.
Embodiment
4
Weighing periplaneta americana fresh worm 4000g, be separately added into the soak by water three times of 24L, 16L, 16L, each 0.5 hour, filter, filtrate is in 60 DEG C of concentrating under reduced pressure, and concentrated solution, in 5 DEG C of cold preservations 8 hours, removes upper strata oils and fats；It is 80% that concentrated solution add ethanol alcohol to be sink to containing alcohol concentration, stands 16 hours, filters, filtrate is dried in 80 DEG C of concentrating under reduced pressure, and dried American-cockroach-extract beats powder with dextrin in the ratio of 1:1.5, crosses 100 mesh sieves, aluminium plastic bag is packed, 4g/ bag, last test package.
By prevention and treatment two experiment, effect of veterinary drug of the present invention will be described further below.
Experimental example
1
Preventive effect in poultry pestilence is being contrasted by veterinary drug of the present invention with vaccine
1
, the veterinary drug of the present invention preventive effect Experimental comparison to fowl plague
1.1 packet and medications
The present inventor uses the medicine of embodiment 1,2 to do effect test during 2013 to 2014 years pestilence easily occur, adds the medicine of 2.0% embodiment 1,2 in feedstuff when morning and evening feeding, 100 chickens (i.e. embodiment controlling experiment group 1 and test group 2) of each nursing.100 chickens all inject avian influenza virus vaccine inoculation preventing and treating.
1.2 experimental result
When feeding 200 chickens carrying out pestilence preventing and treating to 6 months by the medicine of the present invention, test group 1 falls ill 1, and sickness rate is 1.0%, and test group 2 falls ill 4, and sickness rate is 4%, is weak and sickly chicken itself mostly, the chicken average weight gain 1.4 kilograms lived；And when using 100 chickens of existing vaccine control comparative example to 6 months, 15 morbidities, sickness rate 15%, the chicken average weight gain 0.7 kilogram lived.The prevention fowl plague of embodiment 1 prepared by technical scheme is described, and the good results are evident.
2
, the veterinary drug of the present invention preventive effect Experimental comparison to duck pestilence
2.1 packet and medications
The present inventor uses the medicine of embodiment 1,2 to do effect test during 2013 to 2014 years pestilence easily occur, adds the medicine of 2.0% embodiment 1,2 in feedstuff when morning and evening feeding, 100 ducks (i.e. embodiment controlling experiment group 1 and test group 1) of each nursing.100 ducks all inject avian influenza virus vaccine inoculation preventing and treating.
2.2 experimental result
When feeding 200 ducks carrying out pestilence preventing and treating to 6 months by the medicine of the present invention, test group 1 falls ill 1, and effective percentage is 99.0%, and test group 2 falls ill 5, effective percentage 95%, is weak and sickly chicken itself mostly, the chicken average weight gain 1.6 kilograms lived；And when using 100 ducks of prior art vaccine control comparative example to 6 months, 28 morbidities, sickness rate 28%, the chicken average weight gain 0.6 kilogram lived.
In sum, by using the medicine described in embodiment 1,2 with vaccine, fowl plague, duck pestilence to be prevented, experimental result shows, use veterinary drug of the present invention that poultry pestilence is had more preferable preventive effect, use veterinary drug of the present invention the most not accumulate residual, on human body without impact, the immunity of poultry self can also be improved simultaneously, bird flu virus resistant function to external world increases so that poultry is not easy to suffer from pestilence.
Experimental example
2
Veterinary drug of the present invention treats the Contrast on effect of poultry pestilence with doxycycline hydrochloride
1, packet:
During easily pestilence occurring to 2013 to 2014 years, select the chicken of 300 3 week old, these chickens are suffering from fowl plague symptom, and (body temperature raises, spirit is depressed, loss of appetite or do not eat, feather pine is disorderly, it is envious and sheds tears, conjunctiva inflammation, the symptoms such as secretions increase), it is randomly divided into 3 groups, matched group uses doxycycline hydrochloride (Guangzhou Zhuo Ye health veterinary drug company limited produce) to treat, treatment group 1 uses the medicine described in embodiment 1 to treat, and also uses doxycycline hydrochloride to treat while the medicine that treatment group 2 uses embodiment 1.
2, administering mode
Matched group 1: add the 0.02 of people's water yield～the doxycycline of 0.05% in poultry drinking-water, one day 3 times；
Treatment group 1: the medicine described in embodiment 1 of the 2.0% of addition feedstuff when poultry is fed, one day 3 times；
Treatment group 2: be administered simultaneously the medicine described in embodiment 1 and doxycycline, makes compositions according to American-cockroach-extract and doxycycline hydrochloride weight ratio 1:1, and accounting for feedstuff gross weight ratio is 2%, treats, one day 3 times.
3, experimental result
Matched group 1, treatment group 1, the chicken for the treatment of group 2 are carried out isolation treatment 2 weeks, use healing, improvement, the effect that Drug therapy is described effective, invalid, use total effective rate to make the explanation of further effect of drugs, result such as table 1:
| Cure | Take a turn for the better | Effectively | Invalid | Total effective rate | |
| Matched group 1 | 55 | 18 | 10 | 17 | 83% |
| Treatment group 1 | 53 | 12 | 16 | 16 | 84% |
| Treatment group 2 | 72 | 13 | 9 | 6 | 94% |
As in table 1, result is found out, use the treatment group 1 of medicine described in embodiment 1 in the effect for the treatment of poultry pestilence with use the matched group 1 of doxycycline in the effect for the treatment of poultry pestilence the most suitable, owing to doxycycline belongs to antibiotics, it is not easy to be metabolized out in poultry body, and easily produce drug resistance, so considering, can pay the utmost attention to use veterinary drug of the present invention.And treatment group 2 is doxycycline to be used in combination treat with the medicine many poultry pestilence described in embodiment 1, can be seen that from the result of table 1, the effect of drug combination is substantially than medicine effective being used alone doxycycline, embodiment 1, so selecting veterinary drug of the present invention and antibiotic to be carried out drug combination on medicine in treatment poultry pestilence, acquired effect is unpredictable.
In sum, veterinary drug of the present invention can be used in prevention and treatment poultry pestilence, owing to the composition in American-cockroach-extract is the bioactive substances such as small-molecular peptides, free amino acid, protein, so will not accumulate in poultry body, animal does not develops immunity to drugs, noresidue, on human body without impact.The finished product made is used in birds and raises and can promote.
Claims (9)
1. the veterinary drug being used for preventing and treat poultry pestilence, it is characterised in that described veterinary drug is mainly composed of periplaneta americana.
Veterinary drug the most according to claim 1, it is characterised in that its each weight ratio of constituents of described veterinary drug is for being dried American-cockroach-extract: adjuvant=1:0.5～2.
Veterinary drug the most according to claim 1, it is characterised in that its each weight ratio of constituents of described veterinary drug is for being dried American-cockroach-extract: adjuvant=1:1.
Veterinary drug the most according to claim 1, it is characterised in that its each weight ratio of constituents of described veterinary drug is periplaneta americana powder: adjuvant=1:0.5～2.
5. according to the veterinary drug described in claim 2-3, it is characterised in that it is one or more that described adjuvant is selected from dextrin, starch, Icing Sugar.
6. the preparation method of the veterinary drug described in claim 2, it is characterised in that comprise the steps:
A, the dry worm of periplaneta americana add 6～the water of 12 times of crude drug amount volumes or the fresh worm of periplaneta americana adds 4～the soak by water of 8 times of crude drug amount volumes 2～4 times, decoct 0.5～2 hour every time and filter, filtrate is in 60 DEG C～80 DEG C of concentrating under reduced pressure, and concentrated solution, in 5 DEG C～15 DEG C of cold preservations 8～24 hours, removes upper strata oils and fats；
It is 50%～80% that b, concentrated solution step a obtained add ethanol alcohol to be sink to containing alcohol concentration, stand 8～24 hours, filter, filtrate is in 60 DEG C～80 DEG C of concentrating under reduced pressure, dried American-cockroach-extract mixes dozen powder with dextrin according to the ratio of 1:0.5～2, crosses 60～100 mesh sieves, and aluminium plastic bag is packed, 3～8g/ bags, last test package.
7. the preparation method of the veterinary drug described in claim 6, it is characterised in that comprise the steps:
A, dry for periplaneta americana worm will be separately added into 10 times, 8 times, 6 times or will be separately added into the water extraction 3 times of 6 times, 4 times, 4 times crude drug amount volumes in fresh for periplaneta americana worm, each 1 hour, filtrate is in 70 DEG C of concentrating under reduced pressure, and concentrated solution, in 10 DEG C of cold preservations 16 hours, removes upper strata oils and fats；
It is 70% that the concentrated solution that b, step a obtain add ethanol alcohol to be sink to containing alcohol concentration, stands 16 hours, filters, filtrate mixes dozen powder with dextrin according to the ratio of 1:1 in 70 DEG C of concentrating under reduced pressure, dried American-cockroach-extract, crosses 80 mesh sieves, aluminium plastic bag is packed, 3～8g/ bags, last test package.
Veterinary drug the most according to claim 1, it is characterised in that main component American-cockroach-extract and doxycycline hydrochloride weight ratio are 1:1.
Veterinary drug the most according to claim 1, can add in feedstuff as feed additive and be used in conjunction with.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510203750.3A CN105878286A (en) | 2015-04-27 | 2015-04-27 | Veterinary drug for preventing and treating plague in poultry and preparation method of veterinary drug |
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| CN201510203750.3A CN105878286A (en) | 2015-04-27 | 2015-04-27 | Veterinary drug for preventing and treating plague in poultry and preparation method of veterinary drug |
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| CN105878286A true CN105878286A (en) | 2016-08-24 |
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| CN201510203750.3A Pending CN105878286A (en) | 2015-04-27 | 2015-04-27 | Veterinary drug for preventing and treating plague in poultry and preparation method of veterinary drug |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106727798A (en) * | 2016-12-29 | 2017-05-31 | 成都乾坤动物药业股份有限公司 | A kind of pharmaceutical composition of enhance immunity and its production and use |
| CN107812016A (en) * | 2017-11-23 | 2018-03-20 | 大理大学 | A kind of American-cockroach-extract, preparation method and its application in immunological regulation |
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| CN101254212A (en) * | 2008-03-25 | 2008-09-03 | 浙江大学 | Use of valid target of periplaneta americana |
| CN102743739A (en) * | 2012-05-06 | 2012-10-24 | 大理学院 | Preparation method for blattodea polypeptide substance, and medical use of blattodea polypeptide substance in anti-herpesvirus |
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2015
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| CN101254212A (en) * | 2008-03-25 | 2008-09-03 | 浙江大学 | Use of valid target of periplaneta americana |
| CN102743739A (en) * | 2012-05-06 | 2012-10-24 | 大理学院 | Preparation method for blattodea polypeptide substance, and medical use of blattodea polypeptide substance in anti-herpesvirus |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727798A (en) * | 2016-12-29 | 2017-05-31 | 成都乾坤动物药业股份有限公司 | A kind of pharmaceutical composition of enhance immunity and its production and use |
| CN107812016A (en) * | 2017-11-23 | 2018-03-20 | 大理大学 | A kind of American-cockroach-extract, preparation method and its application in immunological regulation |
| CN107812016B (en) * | 2017-11-23 | 2020-03-27 | 大理大学 | Periplaneta americana extract, preparation method and application thereof in immune regulation |
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