CN1058637C - Glossy ganoderma extracting technology - Google Patents
Glossy ganoderma extracting technology Download PDFInfo
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- CN1058637C CN1058637C CN 98120550 CN98120550A CN1058637C CN 1058637 C CN1058637 C CN 1058637C CN 98120550 CN98120550 CN 98120550 CN 98120550 A CN98120550 A CN 98120550A CN 1058637 C CN1058637 C CN 1058637C
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- extracting
- ammonia solution
- extract
- reflux
- ganoderma
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Abstract
The present invention discloses a new process for extracting ganoderma lucidum. The process comprises: firstly, ganoderma lucidum is extracted with an ammonia solution twice; then, the ganoderma lucidum is extracted with water once and is filtered, and filtered solutions are mixed and concentrated. The effective ingredients of the obtained product extracted by the method has high extraction rate and no saline taste, and the method has no corrosion to equipment.
Description
The invention relates to the invention of lucidum extracting method, promptly, belong to the field of Chinese medicines the improvement invention of traditional rare Chinese medicine Ganoderma active ingredient extracting method.
Ganoderma is one of traditional rare Chinese medicine, dietotherapeutic, and make one of mushroom industry, and edible greater than medicinal, produced very big economic benefit and social benefit.But because the fibrosis of Ganoderma medical material adopts common water extracting method up to 80%, it is very low to receive the cream rate, and its dry extract yield is less than 8%.Although bibliographical information is arranged, add extractions such as sodium hydroxide, oxalic acid, ammonium oxalate active ingredient is increased, the dry extract yield improves, and adding sodium hydroxide, oxalic acid, Disodium oxalate. etc. has significant disadvantages.This method is corroded extraction equipment easily, is difficult for neutralizing acid alkalescence, gained finished product salty in the mouth, and the desalination difficulty especially is not suitable for the liquid preparation product.
The object of the invention is exactly to overcome under the situation of above-mentioned shortcoming, in order to improve Ganoderma active ingredient extraction ratio, provides a kind of improved glossy ganoderma extracting technology.
The inventive method is based on following principle and realizes:
Ammonia solution can make fibrous tissue dissociate, and has been equivalent to increase the degree of grinding of medical material.Under the degree of grinding condition of limited, organize dissociation energy to make cell rupture, inclusions is then leached by solvent in the cell.Extract Ganoderma with the method, can make active ingredient and more than 110 kind of contained triterpenes composition and the ammonia salify such as Ganodenic acid of Ganoderma of Ganoderma, easier leaching.
The inventive method is as described below:
With Ganoderma clean, section, pulverize after, extract altogether three times.Wherein the first two times adds 2-10 respectively and doubly measured ammonia solution (0.5%-3% concentration) reflux, extract, 1-3 hour, and medicinal residues add 2-10 times of water gaging again and reflux and carry 1-3 hour, filter, merge three times filtrate, being concentrated into 60 ℃ of heat survey relative densities is about 1.02, and the pH value of concentrated solution is about 6.0, need not neutralize.If make liquid preparation, add micro-citric acid and transfer about PH5.5 and get final product, can not cause the finished product salty in the mouth.
In said method, the first two times extracts the ammonia solution amount added and is preferably and adds 3-8 and doubly measure, preferably 8 times of amounts; The concentration of used ammonia solution is preferably 1%-2%, is preferably 1% (promptly 1: 99).Reflux extracting time is preferably 2 hours.Extract amount of water for the third time and be preferably 8 times of amounts, reflux extracting time is preferably 2 hours.
When making liquid preparation, can add excipient commonly used, flavoring agent, antiseptic etc., for example can add sucrose, cyclamate, sodium glutamate, potassium sorbate, cyclodextrin etc.
Peroral dosage form can be directly made in the Ganoderma active ingredient that the inventive method is extracted, and also can add in other the pharmaceutical composition, as long as adopted lucidum extracting method of the present invention, all belongs to protection scope of the present invention.
The inventive method is compared with extracting method before, has following advantage:
1, the extraction rate height of active ingredient, take this method to extract after, after measured, its active ingredient (ganoderan, amino acid content, n-butyl alcohol extract, trace element, dry extract yield etc.) all increases than conventional water extracting method.See following table for details: the active ingredient extraction rate synopsis of table 1 glossy ganoderma extracting technology and old technology
Table 2, new technology and old technology extract Ganoderma gained amino acid content synopsis
| Old technology (water is carried three times, 2 hours/time) | New technology | |
| Dry extract yield (%) polysaccharide extract rate (%) n-butyl alcohol extract yield (%) amino acid content trace element | 5.97 60.00 1.44 1 1 | 11.80 87.27 2.49 1-2 times 1-10 doubly |
| The aminoacid title | Sample 1 (mg/g) sample 2 (mg/g) |
| Aspartic acid (D) | 0.33 0.25 |
| Glutamic acid (E) | 0.40 0.33 |
| Serine (S) | 0.60 0.45 |
| Glycine (G) | 1.11 0.93 |
| Histidine (H) | 0.14 0.14 |
| Arginine (R) | 0.77 0.55 |
| Threonine (T) | 0.27 0.21 |
| Alanine (A) | 0.25 0.22 |
| Proline (P) | 1.33 1.02 |
| Tyrosine (Y) | 0.01 0.01 |
| Valine (V) | 0.40 0.31 |
| Methionine (M) | 3.22 3.15 |
| Isoleucine (I) | 0.16 0.12 |
| Leucine (L) | 0.21 0.16 |
| Phenylalanine (P) | 0.03 0.01 |
| Lysine (K) | 0.14 0.13 |
Annotate: upward sample 1 is the new technology gained in the table, and sample 2 is the old technology gained.
2, need not neutralizing after the inventive method is extracted, can to reach PH be 6.0, overcome the neutral difficulty of Acidity of Aikalinity in the past.
3, the inventive method is not owing to use highly basic, imputrescibility equipment, and also in extraction, distillation, concentration process, ammonia steam volatilization ease is gone.
Can not cause saline taste when 4, product of the present invention is made liquid preparation, and old technology finished product salty in the mouth, the desalination difficulty especially is not suitable for the liquid preparation product.
Embodiment
Get Ganoderma 300 gram, medical material is through cleaning, the clean after drying of wash quickly, and section is ground into coarse powder, takes by weighing by recipe quantity, reflux, extract, three times, the first two times adds 8 times of amount ammonia solution (1: 99) reflux, extract, 2 hours respectively; Medicinal residues add 8 times of water gaging reflux, extract, 2 hours again, filter, and merge three times filtrate, and (relative density is about 1.02 to be concentrated into about 900ml, 60 ℃ of heat are surveyed), add beta-schardinger dextrin-4g, stir evenly, add sucrose 150g, cyclamate 3g, sodium glutamate 2.5g, potassium sorbate 3g, heating for dissolving filters, and adds water and adjusts volume to 1000ml, the about 0.5g of adding citric acid transfers about pH value to 5.5 again, filters, fill, sterilization is equivalent to about 0.3g crude drug/ml.
Claims (10)
1, a kind of lucidum extracting method, it is characterized in that with Ganoderma clean, section, pulverize after, reflux, extract, is three times altogether, wherein the first two times extracts with ammonia solution, uses water extraction for the last time, filters the back and merges three filtrates, concentrates promptly.
2, according to the method for claim 1, it is characterized in that, add 2-10 when the first two times extracts and doubly measure ammonia solution.
3,, it is characterized in that the first two times adds 3-8 when extracting and doubly measures ammonia solution according to the method for claim 2.
4,, it is characterized in that adding when the first two times extracts 8 times of amount ammonia solutions according to the method for claim 3.
5, according to the method for claim 1, the concentration of used ammonia solution is 0.5%-3% when it is characterized in that extracting.
6, according to the method for claim 5, the concentration of used ammonia solution is 1% when it is characterized in that extracting.
7, according to the method for claim 1, the time that it is characterized in that reflux, extract, is 1-3 hour.
8,, it is characterized in that reflux extracting time is 2 hours according to the method for claim 7.
9, according to the method for claim 1, the pH value that it is characterized in that the gained concentrated solution is 6.0.
10,, it is characterized in that the pH value of concentrated solution is adjusted into 5.5 according to the method for claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98120550 CN1058637C (en) | 1998-10-22 | 1998-10-22 | Glossy ganoderma extracting technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98120550 CN1058637C (en) | 1998-10-22 | 1998-10-22 | Glossy ganoderma extracting technology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1214263A CN1214263A (en) | 1999-04-21 |
| CN1058637C true CN1058637C (en) | 2000-11-22 |
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ID=5226802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 98120550 Expired - Lifetime CN1058637C (en) | 1998-10-22 | 1998-10-22 | Glossy ganoderma extracting technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1058637C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099455C (en) * | 2000-12-25 | 2003-01-22 | 中山大学 | Process for extracting lipid matter of ganoderma spore by immersing extraction |
| CN104137989A (en) * | 2014-07-29 | 2014-11-12 | 湖南正清制药集团股份有限公司 | Sucrose-free ganoderma lucidum oral solution and preparation method thereof |
| CN104257701B (en) * | 2014-09-25 | 2017-07-25 | 齐鲁工业大学 | A kind of method for preparing ganoderma lucidum triterpene compounds |
-
1998
- 1998-10-22 CN CN 98120550 patent/CN1058637C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1214263A (en) | 1999-04-21 |
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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Granted publication date: 20001122 |