CN105857932B - Cryopreservation tube access device - Google Patents
Cryopreservation tube access device Download PDFInfo
- Publication number
- CN105857932B CN105857932B CN201610273913.XA CN201610273913A CN105857932B CN 105857932 B CN105857932 B CN 105857932B CN 201610273913 A CN201610273913 A CN 201610273913A CN 105857932 B CN105857932 B CN 105857932B
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- China
- Prior art keywords
- cryopreservation tube
- frame
- access device
- liquid nitrogen
- component
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/38—Devices for discharging contents
- B65D25/52—Devices for discharging successive articles or portions of contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D61/00—External frames or supports adapted to be assembled around, or applied to, articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Food Science & Technology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a kind of liquid nitrogen container and cryopreservation tube access device, liquid nitrogen container includes tank body, and tank body is provided with opening, and liquid nitrogen container also includes：Rotating disk, rotating disk are arranged in tank body；Frame is frozen, frame is frozen and is carried on rotating disk, freezing frame includes multilayer placed side, and the scope of the angle of every layer of placed side and rotating disk is 40 degree~60 degree；Central shaft, central shaft are vertically arranged with rotating disk and are fixedly connected with rotating disk；Drive component, drive component electrically connect with central shaft；Drive component is used to drive central shaft to rotate, and central shaft is used to freeze frame rotation by driven by rotary disc and will freeze frame to deliver to opening.The present invention reduces the workload of operating personnel, reduces error rate when manually choosing cryopreservation tube, while avoid the potential safety hazard to operating personnel.Present invention is especially suited for the technical need chosen pipe work, meet the biological specimen library storage of Large Copacity of the biological sample bank of Large Copacity.
Description
Technical field
The present invention relates to a kind of liquid nitrogen container and cryopreservation tube access device.
Background technology
Profound hypothermia biological sample bank is the important infrastructure device of current field of medicaments and biological field research work, passes through liquid
The Cord blood of nitrogen can allow the biological tissue such as blood, stem cell and immunocyte stay active for long periods.
At present, nitrogen storage tank is Manual structure, and cover need to be opened when operating personnel select cryopreservation tube, is stretched out one's hand into tank body simultaneously
Whole freeze after disk takes out is chosen into single branch cryopreservation tube again, and during cryopreservation tube is stored in, it is also desirable to taken entirely disk is frozen
Single branch cryopreservation tube, such access mode are restored again into after going out so that the whole ring for freezing disk all more than -196 DEG C of temperature
In border, the biological property of remaining cryopreservation tube torage cell is influenceed, destroys degree of activation of cells, so as to which the skill of cell storage can not be reached
Art demand.In addition, operating efficiency is very low during hand picking cryopreservation tube, error rate is also higher.Moreover, because liquid nitrogen container and cryopreservation tube
Temperature is extremely low, and manually choosing pipe has very big potential safety hazard to operating personnel.
The content of the invention
The technical problem to be solved in the present invention is when manually choosing cryopreservation tube from liquid nitrogen container in the prior art to overcome,
Influence the biological property of remaining cryopreservation tube torage cell, and the defects of operating efficiency is low, error rate is high, there is provided a kind of liquid nitrogen container and
Cryopreservation tube access device.
The present invention is that solve above-mentioned technical problem by following technical proposals：
A kind of liquid nitrogen container, its feature are that the liquid nitrogen container includes tank body, and the tank body is provided with opening, the liquid nitrogen container
Also include：
Rotating disk, the rotating disk are arranged in the tank body；
Frame is frozen, the frame that freezes is carried on the rotating disk, and the frame that freezes includes multilayer placed side, every layer of placed side
Angular range between the rotating disk is 40 degree~60 degree；
Central shaft, the central shaft are vertically arranged with the rotating disk and are fixedly connected with the rotating disk；
Drive component, the drive component electrically connect with the central shaft；
The drive component is used to drive the central shaft to rotate, and the central shaft is used for by described in the driven by rotary disc
Frame is frozen to rotate and the frame that freezes is delivered into the opening.
It is preferred that the angle between every layer of placed side and the rotating disk is 45 degree.
In this programme, every layer of placed side has gradient, and layer is distributed with layer in sawtooth pattern, and cryopreservation tube is accessed so as to convenient,
Simplify the operation link of access.
It is preferred that the drive component includes shaft coupling, plane bearing and motor, the shaft coupling respectively with it is described
Plane bearing and motor connection；
The bottom of the tank body is provided with axle sleeve, and one end of the central shaft is arranged in the axle sleeve, the central shaft
The other end is extended to outside the tank body and is connected with the plane bearing；
The motor is used to drive the shaft coupling to rotate.
In this programme, the motor carries encoder and carries out angular position feedback, so as to monitor the anglec of rotation.
It is preferred that the opening is provided with leading truck；And/or the opening is provided with fibre optical sensor, the optical fiber passes
Sensor electrically connects with the drive component.
In this programme, the leading truck is used to eliminate the position error for freezing and carrying in frame process of rising or falling,
Guarantee, which freezes frame, to be easily stored in or extract, and ensures the reliability of extraction.
In this programme, the zero-bit of the rotating disk can be set by the fibre optical sensor, so as to eliminate the driving group
Caused accumulated error after part operating for a long time.
It is preferred that the liquid nitrogen container also includes one or more limiting plates, the limiting plate is located at the top of the rotating disk,
And be fixedly connected with the central shaft, it is respectively equipped with clamping part on each limiting plate, it is described to freeze erection and be placed in the clamping
In portion.
It is preferred that the clamping part be arranged in parallel with the rotating disk, and the clamping part is provided with several through holes, the jelly
Frame is deposited through the through hole and is carried on the rotating disk.
In this programme, limiting plate can keep freezing stability of the frame in rotary course, will freeze frame and be limited in institute
State defined location on rotating disk, the relative position for ensureing to freeze frame and the rotating disk in rotary course is fixed, so as to by mesh
Mark freeze frame easily, take out exactly.
It is preferred that the quantity of the limiting plate is 2；And/or the quantity of the through hole is 81.
It is preferred that described one end for freezing frame is provided with iron block.
It is preferred that being equipped with 10 standing grooves on every layer of placed side, the standing groove is used to place cryopreservation tube.
It is preferred that the outer layer of the tank body is vacuum heat-insulating layer.
In this programme, the vacuum heat-insulating layer ensure that the low temperature environment in the tank body.
A kind of cryopreservation tube access device, its feature are that the cryopreservation tube access device includes liquid nitrogen container described above, institute
Stating cryopreservation tube access device also includes shell, cryopreservation tube access element and the docking port with the open butt joint of the liquid nitrogen container, institute
Opening is stated to dock with docking port sealing；
The cryopreservation tube access element is arranged in the shell, and the cryopreservation tube access element be used for by cryopreservation tube from
Extract or be stored in the liquid nitrogen container.
It is preferred that the cryopreservation tube access element includes freezing frame control sub-component and cryopreservation tube control sub-component；
The frame control sub-component that freezes is arranged at the docking port, and the cryopreservation tube control sub-component is arranged at described
Freeze on frame control sub-component；
The frame control sub-component that freezes is extracted or is stored in from the liquid nitrogen container for that will freeze frame, the cryopreservation tube control
Sub-component is used to control what sub-component extracted to freeze extraction or deposit in frame from by the frame that freezes the cryopreservation tube.
It is preferred that the frame control sub-component that freezes includes：
First framework, first framework are fixedly installed in the shell；
Mechanical arm controlling organization, the mechanical arm controlling organization are arranged on first framework；
Mechanical arm, the mechanical arm are arranged on the mechanical arm controlling organization, and the mechanical arm is used for the jelly
Frame is deposited to extract or be stored in from the liquid nitrogen container.
It is preferred that the mechanical arm controlling organization includes at least one first single shaft control mechanism and a second single shaft control
Mechanism processed；
The first single shaft control mechanism is arranged on first framework, and the second single shaft control mechanism is slideably
It is arranged in the first single shaft control mechanism, the mechanical arm is slidably disposed in the second single shaft control mechanism；
The first single shaft control mechanism is used to make the second single shaft control mechanism slide along horizontal direction, and described the
Two single shaft control mechanisms are used to make the mechanical arm slide along vertical direction.
It is preferred that the mechanical arm controlling organization also includes pad rack, the first single shaft control mechanism and described the
Two single shaft control mechanisms pass through the pad rack vertical connection.
It is preferred that one end of the mechanical arm is provided with connector, the connector is used to the frame that freezes being connected to
On the mechanical arm.
It is preferred that the connector includes electromagnet, and when described one end for freezing frame is provided with iron block, the electromagnet
For being connected with the iron block.
It is preferred that the frame control sub-component that freezes also includes the first liquid nitrogen spray device, the first liquid nitrogen spray device is set
It is placed on first framework.
In this programme, the first liquid nitrogen spray device sprays a certain amount of liquid nitrogen to the enclosure, with guarantee
Portion's temperature meets the security of biological specimen in cryopreservation tube.
It is preferred that the frame control sub-component that freezes also includes the first temperature sensor, first temperature sensor is set
It is placed on first framework, first temperature sensor electrically connects with the first liquid nitrogen spray device.
In this programme, first temperature sensor sends a signal to described first when monitoring that temperature is too high
Liquid nitrogen spray device, then the first liquid nitrogen spray device is from enclosure injection liquid nitrogen described in trend, and guarantee is lifted or deposit freezes
Biological specimen is carried out within the scope of suitable temperature all the time during frame, so as to ensure the safety of biological specimen.
It is preferred that the cryopreservation tube control sub-component includes：
Second framework, second framework are fixedly installed in the shell；
Cryopreservation tube Pai Xi mechanisms, the cryopreservation tube Pai Xi mechanisms are arranged on second framework, and the cryopreservation tube row inhales
Mechanism is used to control what sub-component extracted to freeze extraction or deposit in frame from by the frame that freezes the cryopreservation tube；
Cryopreservation tube selects mechanism, and the cryopreservation tube is selected mechanism and is arranged in the cryopreservation tube Pai Xi mechanisms, described to freeze
Pipe selects mechanism and is used to select the cryopreservation tube that need to be extracted or be stored in.
It is preferred that the cryopreservation tube Pai Xi mechanisms include：
Straight line electric cylinders, the straight line electric cylinders are along horizontally arranged on second framework；
Row inhales component, and the angular range that the row inhales between component and the rotating disk of the liquid nitrogen container is 40 degree~60 degree, institute
Component is inhaled by the row of stating includes several row's suction nozzles, and each row's suction nozzle is selected mechanism with the cryopreservation tube respectively and connected by breather pipe
Connect；
Fixed mount, the fixed mount are fixedly installed in the straight line electric cylinders, and the row inhales component and is arranged at the fixation
On frame.
It is preferred that the angle that the row is inhaled between component and the rotating disk is 45 degree.
It is preferred that being respectively equipped with into pipe joint outside the shell and going out pipe joint, the cryopreservation tube, which selects mechanism, to be included：
Middle unloading pipe dish, the middle unloading pipe dish are arranged on second framework, and the middle unloading pipe dish is annual disk,
And at least three access through holes are offered respectively along the radial direction of the middle unloading pipe dish, the middle unloading pipe dish is deposited at each
Take and an access joint be respectively equipped with one end of through hole, two access joints respectively with it is described enter pipe joint and the outlet pipe
Joint is connected by breather pipe, and remaining each access joint is connected with row's suction nozzle by breather pipe respectively；
Pipe fitting is chosen in rotation, and the rotation is chosen pipe fitting and is arranged at the ring interior location of the middle unloading pipe dish, the rotation
The opening portion for choosing pipe fitting corresponds respectively to the other end of the middle unloading pipe dish in each access through hole, and pipe is chosen in the rotation
Accommodating cavity is provided with part, the accommodating cavity is used to house cryopreservation tube, and the rotation chooses pipe fitting and is used to drawing or discharging described freeze
Pipe；
Electric cylinders are rotated, the rotation electric cylinders are fixedly installed on second framework, and the rotation chooses pipe fitting and is arranged at institute
State in rotation electric cylinders, the rotation electric cylinders are rotated for driving rotation to choose pipe fitting.
It is preferred that the rotation is chosen and port is offered on pipe fitting, and the port is connected with the accommodating cavity, institute
State and gas source connector is provided with port, the gas source connector is connected by breather pipe with source of the gas, and the source of the gas is used for by described
Port carries out air inlet or air-breathing.
It is preferred that the quantity of row's suction nozzle is 10, the quantity for accessing joint is 12.
It is preferred that the rotation is chosen and sealed between the opening portion of pipe fitting and the middle unloading pipe dish by encapsulant.
It is preferred that the cryopreservation tube control sub-component also includes the second liquid nitrogen spray device, the second liquid nitrogen spray device is set
It is placed on second framework.
In this programme, the second liquid nitrogen spray device is selected to the cryopreservation tube sprays a certain amount of liquid nitrogen at mechanism,
To ensure that internal temperature meets the security of biological specimen in cryopreservation tube.
It is preferred that the cryopreservation tube control sub-component also includes second temperature sensor, the second temperature sensor is set
It is placed on second framework, the second temperature sensor electrically connects with the second liquid nitrogen spray device.
In this programme, the second temperature sensor sends a signal to described second when monitoring that temperature is too high
Liquid nitrogen spray device, then the second liquid nitrogen spray device is selected from cryopreservation tube described in trend sprays liquid nitrogen at mechanism, mesh is selected in guarantee
Biological specimen is carried out within the scope of suitable temperature all the time during mark cryopreservation tube, so as to ensure the safety of biological specimen.
It is preferred that the cryopreservation tube access device also includes electric-control system, the electric-control system accesses with the cryopreservation tube
Component electrically connects.
In this programme, the automation of cryopreservation tube access procedure is realized by the electric-control system, so as to reduce work
Amount, improves efficiency.
It is preferred that the shell is insulation insulated shell.
In this programme, the insulation insulated shell can ensure that cryopreservation tube is not exposed to extraneous ring during extraction or deposit
In border, while the low temperature in the cryopreservation tube access device can be ensured, to prevent heat conduction loss cold.
It on the basis of common sense in the field is met, above-mentioned each optimum condition, can be combined, it is each preferably real to produce the present invention
Example.
The positive effect of the present invention is：
Liquid nitrogen container provided by the invention realizes the rotation of rotating disk by drive component, it is convenient to choose target cryopreservation tube,
So as to ensure that the biological property of remaining cell pipe torage cell, and reduce the workload of operating personnel, reduce and manually choose
Go out error rate during cryopreservation tube, while avoid the potential safety hazard to operating personnel.
Target cryopreservation tube easily can be stored in liquid nitrogen container by cryopreservation tube access device provided by the invention, or from liquid nitrogen container
Take out target cryopreservation tube, realize the full-automatic storing process of single branch access sample, avoid non-targeted cryopreservation tube exposed to-
In environment more than 196 DEG C of temperature, so as to ensure that the activity of biological specimen, and operation link is simplified.The present invention is by each
The combination of mechanical moving element and the monitoring of each sensor, the strict control of the whole temperature environment for choosing pipe process is realized, allow life
Thing Sample Storehouse chooses pipe process more efficiently, reliably.
Present invention is especially suited for the biological specimen stock for choosing pipe work, meeting Large Copacity of the biological sample bank of Large Copacity
The technical need of storage.
Brief description of the drawings
Fig. 1 is the structural representation of the liquid nitrogen container of present pre-ferred embodiments.
Fig. 2 is the structural representation at limiting plate in the liquid nitrogen container of present pre-ferred embodiments.
Fig. 3 is the structural representation that frame is frozen in the liquid nitrogen container of present pre-ferred embodiments.
Fig. 4 is that the structural representation at frame control sub-component is frozen in the cryopreservation tube access device of present pre-ferred embodiments
Figure.
Fig. 5 controls the structural representation at sub-component for cryopreservation tube in the cryopreservation tube access device of present pre-ferred embodiments
Figure.
Fig. 6 selects the structural representation of mechanism for cryopreservation tube in the cryopreservation tube access device of present pre-ferred embodiments.
Fig. 7 is the structural representation of the cryopreservation tube access device of present pre-ferred embodiments.
Description of reference numerals：
Liquid nitrogen container 1
Tank body 101
Rotating disk 102
Central shaft 103
Freeze frame 104
Placed side 105
Standing groove 106
Motor 107
Shaft coupling 108
Plane bearing 109
Leading truck 110
Opening 111
Limiting plate 112
Through hole 113
Iron block 114
Vacuum heat-insulating layer 115
Cryopreservation tube access device 2
Shell 201
Docking port 202
First framework 203
First single shaft control structure 204
Second single shaft control structure 206
Pad rack 207
Mechanical arm 208
Connector 209
Electromagnet 210
First liquid nitrogen spray device 211
Second framework 212
Arrange suction nozzle 213
Breather pipe 214
Straight line electric cylinders 215
Fixed mount 216
Middle unloading pipe dish 217
Access joint 218
Access through hole 219
Enter pipe joint 220
Pipe fitting 221 is chosen in rotation
Rotate electric cylinders 222
Gas source connector 223
Liquid nitrogen joint 224
Second liquid nitrogen spray device 225
It is incubated insulated shell 226
Embodiment
Name preferred embodiment, and become apparent from intactly illustrating the present invention with reference to accompanying drawing.
As shown in Figure 1 to Figure 3, the liquid nitrogen container 1 that the present embodiment provides includes tank body 101, rotating disk 102, central shaft 103, jelly
Frame 104,2 limiting plates 112 and drive components are deposited, the internal temperature most low energy of tank body 101 reaches -196 DEG C, the environment with outside
Temperature-difference is very big, therefore the outer layer of tank body 101 is set to double-layered vacuum heat-insulation layer, in order to meet the needs of material stress, this
Tank body 101 is designed to the cylinder double-layer vacuum structure of lower arcuate by embodiment.
Wherein, the bottom inside tank body 101 is liquid nitrogen layer, has liquid nitrogen, is rotating disk 102 above the liquid nitrogen layer, is turned
Disk 102 is arranged in tank body 101.Freeze frame 104 to be erected on rotating disk 102, rotating disk 102 freezes frame 104 for carrying, such as Fig. 3
Shown, freezing frame 104 includes multilayer placed side 105, and every layer of placed side 105 offers 10 standing grooves 106, a cryopreservation tube pair
Should be positioned in a standing groove 106, frozen not shown in the present embodiment frame 104 particular number and placed side 105 it is specific
The number of plies, it can be set according to actual conditions, the quantity of standing groove 106 can be also adjusted correspondingly according to actual conditions.Each
Individual to freeze in frame 104, the angle between every layer of placed side 105 and rotating disk 102 is disposed as 45 degree, to cause every layer of placed side
105 have gradient, and layer is distributed with layer in sawtooth pattern, so as to the convenient operation link for accessing cryopreservation tube, simplifying access.Freeze frame
104 top is provided with iron block 114, and iron block 114 is used to be connected with magnet, so as to which convenient extraction or deposit entirely freeze frame
104。
Central shaft 103 is vertically arranged with rotating disk 102 and is fixedly connected with rotating disk 102, and the drive component is arranged at tank body
101 top, and electrically connect with central shaft 103, it is necessary to extract when freezing frame 104, the drive component is used to drive central shaft
103 rotation and by target freeze frame deliver to opening 111 at, its split shed 111 is arranged at the top non-central location of tank body 101,
The size of opening 111 can accommodate deposit or extraction that 3 row freeze frame 104.Easily it can be stored in or carry to ensure to freeze frame 104
Take, and ensure the reliability of extraction, as shown in figure 1, leading truck 110 is provided with opening 111, at the port of leading truck 110
With 45 degree of inclined-planes, corresponding to placed side 105 so that convenient extraction or deposit freeze frame 104, and leading truck 110, which is used to eliminate, to be frozen
The position error carried in the process of rising or falling of frame 104 is deposited, there is guide function.It is open at 111 and is additionally provided with Fibre Optical Sensor
Device (not shown), the fibre optical sensor are electrically connected with the drive component, and rotating disk is set by the fibre optical sensor
102 zero-bit, so as to eliminate caused accumulated error after drive component operating for a long time.
Specifically, the drive component includes motor 107, shaft coupling 108 and plane bearing 109, the bottom of tank body 101
Portion is provided with axle sleeve (not shown), and central shaft 103 runs through rotating disk 102, and rotating disk 102 is fixed in the portion on the lower of central shaft 103
Point, one end of central shaft 103 is arranged in the axle sleeve, and the other end is extended to outside tank body 101 and connected with plane bearing 109
Connect, motor 107 is connected by shaft coupling 108 with plane bearing 109, and motor 107 is used to drive plane bearing 109 to revolve
Turn, so as to drive central shaft 103 to rotate, the driving rotating disk 102 of central shaft 103 rotates, and motor 107 carries encoder and carries out angle
Position feedback is spent, so as to monitor the anglec of rotation.Its turntable 102 is a disk more smaller than the internal diameter of tank body 101, and above
Several small sircle hole (not shown)s can be set, so as to facilitate liquid nitrogen vapor to pass through.
2 limiting plates 112 are located at the top of rotating disk 102 respectively, and are fixedly connected with central shaft 103, therefore can be in
Mandrel 103 is rotated, and clamping part is respectively equipped with each limiting plate 112, is frozen frame 104 and is arranged in the clamping part.Specifically
, as shown in Fig. 2 limiting plate 112 can be a disk more smaller than the internal diameter of tank body 101, and it is be arranged in parallel with rotating disk 102,
The clamping part of each limiting plate 112 is respectively equipped with 81 through holes 113, the size of through hole 113 and the size phase for freezing frame 104
Match somebody with somebody, freeze frame 104 through through hole 113 and being carried on rotating disk 102, limiting plate 112, which can keep freezing frame 104, to be rotated through
Stability in journey, frame 104 will be frozen and be limited in defined location on rotating disk 102, ensure to freeze frame 104 in rotary course with turning
The relative position of disk 102 is fixed, and easily, is exactly taken out so as to which target is frozen into frame.It is although specific in the present embodiment
The quantity of limiting plate 112 and through hole 113 is shown, it is not limited to this quantity, can be adjusted accordingly according to actual conditions
It is whole.Certainly, the clamping part on limiting plate 112 is not limited to set the form or buckle of through hole on the disk in the present embodiment
Etc. form.
In the present embodiment, information labels are posted on each cryopreservation tube, when needing to take some cryopreservation tube in liquid nitrogen container
When, the drive component first obtains the label information on the cryopreservation tube that need to be extracted, to determine to freeze rack position where cryopreservation tube,
After information determines, motor 107 rotates rotating disk 102, and the frame that freezes for being stored with target cryopreservation tube is turned into opening
On position, the target that operating personnel can then will rotate to opening freezes frame by the taking-up of the parts such as magnet, carries out next step
Cryopreservation tube picking works.When needs, which will freeze frame, is put back into liquid nitrogen container, the process that its process freezes frame with taking out is similar, herein
Repeat no more.
The liquid nitrogen container that the present embodiment provides can easily choose target cryopreservation tube, so as to ensure that the storage of remaining cell pipe is thin
The biological property of born of the same parents, and reduce the workload of operating personnel, reduce error rate when manually choosing cryopreservation tube, avoid simultaneously
To the potential safety hazard of operating personnel.
As shown in Figures 4 to 7, the cryopreservation tube access device 2 that the present embodiment also provides includes above-mentioned liquid nitrogen container 1, shell
201st, the docking port 202 and cryopreservation tube access element docked with the opening 111 of liquid nitrogen container 1, the cryopreservation tube access element include
Frame control sub-component and cryopreservation tube control sub-component are frozen, the frame control sub-component that freezes is arranged at docking port 202, described
Cryopreservation tube control sub-component is arranged at described freeze on frame control sub-component.
Wherein, shell 201 is insulation insulated shell 226, and can ensure that cryopreservation tube is not exposed to during extraction or deposit
In external environment, while the low temperature in cryopreservation tube access device 2 can be ensured, to prevent heat conduction loss cold, opening 111 with it is right
The sealing docking of interface 202, the frame control sub-component that freezes extract for that will freeze frame 104 by docking port 202 from liquid nitrogen container 1
Or deposit, the cryopreservation tube control sub-component are used for target cryopreservation tube from by the jelly for freezing frame and controlling sub-component to extract
Deposit and extract or be stored in frame 104.
As shown in figure 4, the frame control sub-component that freezes includes the first framework 203, mechanical arm controlling organization and mechanical arm
208, the mechanical arm controlling organization includes two the first single shaft control mechanisms 204, the second single shaft control mechanism 206 and backing plate branch
Frame 207, the mechanical arm controlling organization are used for the position of control machinery arm 208, and one end of mechanical arm 208 is provided with connector
209, connector 209 includes electromagnet 210, and electromagnet 210 is used to be connected with freezing the iron block 114 of frame 104.
Specifically, the first framework 203 is fixedly installed in shell 201, two the first single shaft control mechanisms 204 are set respectively
It is placed on the first framework 203, the second single shaft control mechanism 206 is respectively slidably arranged at two the first single shaft control mechanisms
On 204, and it is slidably disposed in by the vertical connection of 207 and first single shaft control mechanism of pad rack 204, mechanical arm 208
In second single shaft control mechanism 206, the first single shaft control mechanism 204 is used to control the second single shaft control mechanism 206 and mechanical arm
208 are slided along horizontal direction, and the second single shaft control mechanism 206 is slided for control machinery arm 208 along vertical direction.
When extraction freezes frame 104 from liquid nitrogen container 1, with reference to shown in Fig. 1 and Fig. 4, first docking port 202 and opening 111 are entered
Row docking, after docking by target freeze frame turn to opening 111 at, the control machinery arm 208 of the first single shaft control mechanism 204 along
Rotating disk 102 radially slides, and 3 row stopped at opening 111 freeze target in frame and frozen corresponding to frame on horizontal level, adjust
After the horizontal level of whole mechanical arm 208, the control machinery arm 208 of the second single shaft control mechanism 206 along moving straight down, until
Electromagnet 210 touches the iron block 114 that target freezes frame, and now, the electronic control module of mechanical arm 208 is powered to electromagnet 210,
Electromagnet 210 and iron block 114 by magnetic attraction together with, after adhesive control machinery arm 208 along moving straight up, from
And extract target and freeze frame, wait for choosing pipe work in next step.Similarly, target is frozen into frame to send back in liquid nitrogen container 1
Process and said process are contrary operation, therefore are repeated no more.
In the present embodiment, the steady of frame is frozen in order to ensure that the control machinery arm 208 of the second single shaft control mechanism 206 accesses
Property, there is provided two the first single shaft control mechanisms 204 be arrangeding in parallel, and one of them first single shaft control mechanism 204 mainly rises
Booster action, and two the first single shaft control mechanisms 204 keep synchronous operation, so as to improve the stability in control process.
The frame control sub-component that freezes (does not show also including the first liquid nitrogen spray device 211 and the first temperature sensor in figure
Go out), the first liquid nitrogen spray device 211 is multiinjector structure, and the first liquid nitrogen spray device 211 is arranged on the first framework 203, and is pacified
Dress height the second single shaft control mechanism 206 electronic control module and mechanical arm 208 electronic control module lower section, so as to avoid first
The liquid nitrogen that liquid nitrogen spray device 211 sprays has influence on the operation of electronic control module, before needing access target to freeze frame, the first liquid nitrogen
Injector 211 is to a certain amount of liquid nitrogen of the internal spray of shell 201, to ensure that internal temperature meets the peace of biological specimen in cryopreservation tube
Quan Xing, first temperature sensor are arranged on first framework, first temperature sensor and first liquid nitrogen
Injector electrically connects, and when monitoring that temperature is too high, first temperature sensor sends a signal to the first liquid nitrogen spray device
211, then the first liquid nitrogen spray device 211 is automatically to the internal spray liquid nitrogen of shell 201, and guarantee is lifted or deposit target freezes frame
During biological specimen carried out all the time within the scope of suitable temperature, so as to ensure the safety of biological specimen.
As shown in figure 5, the cryopreservation tube control sub-component includes the second framework 212, cryopreservation tube Pai Xi mechanisms and cryopreservation tube
Mechanism is selected, the second framework 212 is fixedly installed in shell 201, and the cryopreservation tube Pai Xi mechanisms are arranged at the second framework 212
On, the cryopreservation tube is selected mechanism and is arranged in the cryopreservation tube Pai Xi mechanisms, and the cryopreservation tube Pai Xi mechanisms are used to freeze
Pipe from by it is described freeze that frame controls that sub-component extracts freeze and extract or be stored in frame, the cryopreservation tube selects mechanism and is used to choose
Select the cryopreservation tube that need to be extracted or be stored in.
Specifically, the cryopreservation tube Pai Xi mechanisms, which include straight line electric cylinders 215, fixed mount 216 and row, inhales component, straight line electric cylinders
215 on the second framework 212, fixed mount 216 is fixedly installed in straight line electric cylinders 215 along horizontally arranged, and the row inhales
Component is arranged on fixed mount 216, and the row, which inhales component, includes 10 row's suction nozzles 213, and row's suction nozzle 213 is used to inhale from standing groove
Cryopreservation tube is taken or discharges, arranging the quantity of suction nozzle 213 can be carried out accordingly according to the quantity of the standing groove on one layer of placed side 105
Adjustment, each row's suction nozzle 213 are selected mechanism with the cryopreservation tube respectively and are connected by breather pipe 214, and each row's suction nozzle
Angle between 213 and the rotating disk of liquid nitrogen container is 45 degree, has identical gradient to arrange suction nozzle 213 and placed side 105,
So as to convenient cryopreservation tube is drawn or discharged to standing groove.
With reference to shown in Fig. 5 and Fig. 6, the cryopreservation tube select mechanism include middle unloading pipe dish 217, rotation choose pipe fitting 221 and
Rotate electric cylinders 222.It is respectively equipped with outside shell 201 into pipe joint 220, goes out pipe joint and (in the visual angle of accompanying drawing go out pipe joint with entering
Pipe joint 220 is overlapping, therefore not shown in figure) and liquid nitrogen joint 224, liquid nitrogen joint 224 connect the liquid nitrogen source of supply of outside, and
Liquid nitrogen is supplemented to cryopreservation tube access device 2 by liquid nitrogen joint 224.Middle unloading pipe dish 217 is arranged on the second framework 212, in
Unloading pipe dish 217 is annual disk, and offers 12 access through holes 219, middle unloading respectively along the radial direction of middle unloading pipe dish 217
Pipe dish 217 is respectively equipped with an access joint 218, two of which access joint on one end at each access through hole 219
218 respectively with enter pipe joint 220 and it is described go out pipe joint be connected by breather pipe 214, remaining 10 access joint 218 respectively with
Corresponding row suction nozzle 213 connects by breather pipe 214 and (two breather pipes 214 is only schematically drawn in figure), each
The structure all same of joint 218 is accessed, therefore accesses joint 218 and which joint to be connected not specifically limited, access joint with
218 quantity can be also adjusted correspondingly according to the quantity of row's suction nozzle 213.Rotation chooses pipe fitting 221 and is arranged at middle unloading pipe dish
At 217 ring interior location, the opening portion of pipe fitting 221 is chosen in rotation, and to correspond respectively to middle unloading pipe dish 217 logical in each access
The other end at hole 219, and rotation is chosen and sealed between the opening portion of pipe fitting 221 and middle unloading pipe dish 217 by encapsulant,
Rotation is chosen and accommodating cavity (not shown) is provided with pipe fitting 221, and the accommodating cavity is used to house cryopreservation tube, and pipe fitting 221 is chosen in rotation
For drawing or discharging the cryopreservation tube, rotation, which is chosen, offers port on pipe fitting 221, and the port and the accommodating cavity
It is connected, gas source connector 223 is provided with the port, gas source connector 223 is connected by breather pipe with source of the gas, and the source of the gas is used
Air inlet or air-breathing are carried out in passing through the port.Rotation electric cylinders 222 are fixedly installed on the second framework 212, and pipe fitting is chosen in rotation
221 are arranged in rotation electric cylinders 222, and rotation electric cylinders 222 carry encoder rotary angle controllable, and rotation electric cylinders 222 are used for band
Dynamic rotation is chosen pipe fitting 221 and rotated.
When freezing extraction target cryopreservation tube in frame from the target being extracted, the lifting of mechanical arm 208 freezes frame and puts target
The face of putting is aligned to the row and inhaled at component, and straight line electric cylinders 215 control the row to inhale component and be aligned to each row's suction nozzle 213
The opening position of a corresponding standing groove, according to the position of target cryopreservation tube, rotation electric cylinders 222 drive rotation to choose pipe fitting 221 simultaneously
The opening portion that rotation is chosen to pipe fitting 221 is aligned to object access through hole, and object access through hole, which is communicated to, draws target cryopreservation tube
Row's suction nozzle, now, the source of the gas by the port carry out air-breathing, target cryopreservation tube by corresponding breather pipe draw to
In the accommodating cavity, after target cryopreservation tube is contained in the accommodating cavity, rotation chooses pipe fitting 221 and rotates again and rotation is chosen into pipe fitting
221 opening portion goes out access through hole corresponding to pipe joint described in being aligned to, and now, the source of the gas is carried out by the port
Deflate, target cryopreservation tube is transported to the outlet pipe joint by corresponding breather pipe, operating personnel from it is described go out pipe joint carry
Take target cryopreservation tube.Similarly, it is contrary operation target cryopreservation tube to be stored in the process of frame and said process is frozen, operating personnel
Target cryopreservation tube can be stored in by entering pipe joint 220, therefore repeated no more.
It (is to show in figure that the cryopreservation tube control sub-component, which also includes the second liquid nitrogen spray device 225 and second temperature sensor,
Go out), the second liquid nitrogen spray device 225 and the second temperature sensor are respectively arranged on the second framework 212, and second temperature
Degree sensor electrically connects with the second liquid nitrogen spray device 225, before access target cryopreservation tube is needed, the second liquid nitrogen spray device 225
Selected to the cryopreservation tube and a certain amount of liquid nitrogen is sprayed at mechanism, to ensure that internal temperature meets the peace of biological specimen in cryopreservation tube
Quan Xing, the structure of the second liquid nitrogen spray device 225 and the first liquid nitrogen spray device 211, the function of the second temperature sensor and institute
It is similar to state the function of the first temperature sensor, therefore repeats no more.
In the present embodiment, cryopreservation tube access device 2 also includes electric-control system (not shown), the electric-control system with
The cryopreservation tube access element electrical connection, the automation of cryopreservation tube access procedure is realized by the electric-control system, so as to reduce
Workload, improves efficiency.
Target cryopreservation tube easily can be stored in liquid nitrogen container by the cryopreservation tube access device that the present embodiment provides, or from liquid nitrogen container
Middle taking-up target cryopreservation tube, the full-automatic storing process of single branch access sample is realized, avoid non-targeted cryopreservation tube exposure
In environment more than -196 DEG C of temperature, so as to ensure that the activity of biological specimen, and operation link is simplified.The present embodiment leads to
The combination of each mechanical moving element and the monitoring of each sensor are crossed, realizes the strict control of the whole temperature environment for choosing pipe process,
Allow biological sample bank choose pipe process more efficiently, it is reliable.
The pipe of choosing that the cryopreservation tube extraction element that the present embodiment provides is particularly suitable for the biological sample bank of Large Copacity works, and meets
The technical need of the biological specimen library storage of Large Copacity.
Although the foregoing describing the embodiment of the present invention, it will be appreciated by those of skill in the art that these
It is merely illustrative of, protection scope of the present invention is defined by the appended claims.Those skilled in the art is not carrying on the back
On the premise of principle and essence from the present invention, various changes or modifications can be made to these embodiments, but these are changed
Protection scope of the present invention is each fallen within modification.
Claims (26)
1. a kind of cryopreservation tube access device, it is characterised in that the cryopreservation tube access device includes liquid nitrogen container, the liquid nitrogen container bag
Tank body is included, the tank body is provided with opening, and the liquid nitrogen container also includes：
Rotating disk, the rotating disk are arranged in the tank body；
Frame is frozen, the frame that freezes is carried on the rotating disk, and the frame that freezes includes multilayer placed side, every layer of placed side and institute
It is 40 degree~60 degree to state the angular range between rotating disk；
Central shaft, the central shaft are vertically arranged with the rotating disk and are fixedly connected with the rotating disk；
Drive component, the drive component electrically connect with the central shaft；
The drive component is used to drive the central shaft to rotate, and the central shaft is used for by being frozen described in the driven by rotary disc
Frame rotates and the frame that freezes is delivered into the opening；
The cryopreservation tube access device also includes shell, cryopreservation tube access element and docked with the open butt joint of the liquid nitrogen container
Mouthful, the opening is docked with docking port sealing；
The cryopreservation tube access element is arranged in the shell, and the cryopreservation tube access element is used for cryopreservation tube from described
Extract or be stored in liquid nitrogen container；
The cryopreservation tube access element includes freezing frame control sub-component and cryopreservation tube control sub-component；
The frame control sub-component that freezes is arranged at the docking port, and the cryopreservation tube control sub-component is arranged at described freeze
On frame control sub-component；
The frame control sub-component that freezes is extracted or is stored in from the liquid nitrogen container for that will freeze frame, and the cryopreservation tube controls subgroup
Part is used to control what sub-component extracted to freeze extraction or deposit in frame from by the frame that freezes the cryopreservation tube；
The cryopreservation tube control sub-component includes：
Second framework, second framework are fixedly installed in the shell；
Cryopreservation tube Pai Xi mechanisms, the cryopreservation tube Pai Xi mechanisms are arranged on second framework, the cryopreservation tube Pai Xi mechanisms
For by the cryopreservation tube from by it is described freeze that frame controls that sub-component extracts freeze and extract or be stored in frame；
Cryopreservation tube selects mechanism, and the cryopreservation tube is selected mechanism and is arranged in the cryopreservation tube Pai Xi mechanisms, and the cryopreservation tube is chosen
Mechanism is selected to be used to select the cryopreservation tube that need to be extracted or be stored in；
The frame control sub-component that freezes includes：
First framework, first framework are fixedly installed in the shell；
Mechanical arm controlling organization, the mechanical arm controlling organization are arranged on first framework；
Mechanical arm, the mechanical arm are arranged on the mechanical arm controlling organization, and the mechanical arm is used to freeze frame by described
Extract or be stored in from the liquid nitrogen container.
2. cryopreservation tube access device as claimed in claim 1, it is characterised in that the mechanical arm controlling organization includes at least one
Individual first single shaft control mechanism and a second single shaft control mechanism；
The first single shaft control mechanism is arranged on first framework, and the second single shaft control mechanism is mounted slidably
In in the first single shaft control mechanism, the mechanical arm is slidably disposed in the second single shaft control mechanism；
The first single shaft control mechanism is used to make the second single shaft control mechanism slide along horizontal direction, and described second is single
Axle controlling organization is used to make the mechanical arm slide along vertical direction.
3. cryopreservation tube access device as claimed in claim 2, it is characterised in that the mechanical arm controlling organization also includes backing plate
Support, the first single shaft control mechanism and the second single shaft control mechanism pass through the pad rack vertical connection.
4. cryopreservation tube access device as claimed in claim 1, it is characterised in that one end of the mechanical arm is provided with connection
Part, the connector are used to the frame that freezes being connected to the mechanical arm.
5. cryopreservation tube access device as claimed in claim 4, it is characterised in that the connector includes electromagnet, when described
When freezing one end of frame and being provided with iron block, the electromagnet is used to be connected with the iron block.
6. cryopreservation tube access device as claimed in claim 1, it is characterised in that the frame control sub-component that freezes also includes the
One liquid nitrogen spray device, the first liquid nitrogen spray device are arranged on first framework.
7. cryopreservation tube access device as claimed in claim 6, it is characterised in that the frame control sub-component that freezes also includes the
One temperature sensor, first temperature sensor are arranged on first framework, first temperature sensor with it is described
First liquid nitrogen spray device electrically connects.
8. cryopreservation tube access device as claimed in claim 1, it is characterised in that the cryopreservation tube Pai Xi mechanisms include：
Straight line electric cylinders, the straight line electric cylinders are along horizontally arranged on second framework；
Row inhales component, and the angular range that the row inhales between component and the rotating disk of the liquid nitrogen container is 40 degree~60 degree, the row
Inhaling component includes several row's suction nozzles, and each row's suction nozzle is selected mechanism with the cryopreservation tube respectively and is connected by breather pipe；
Fixed mount, the fixed mount are fixedly installed in the straight line electric cylinders, and the row inhales component and is arranged on the fixed mount.
9. cryopreservation tube access device as claimed in claim 8, it is characterised in that the row is inhaled between component and the rotating disk
Angle is 45 degree.
10. cryopreservation tube access device as claimed in claim 8, it is characterised in that be respectively equipped with outside the shell into pipe joint
And going out pipe joint, the cryopreservation tube, which selects mechanism, to be included：
Middle unloading pipe dish, the middle unloading pipe dish are arranged on second framework, and the middle unloading pipe dish is annual disk, and edge
The radial direction for the middle unloading pipe dish offers at least three access through holes respectively, and the middle unloading pipe dish is logical in each access
Be respectively equipped with an access joint on one end at hole, two access joints respectively with it is described enter pipe joint and it is described go out pipe joint
Connected by breather pipe, remaining each access joint is connected with row's suction nozzle by breather pipe respectively；
Pipe fitting is chosen in rotation, and the rotation is chosen pipe fitting and is arranged at the ring interior location of the middle unloading pipe dish, and pipe is chosen in the rotation
The opening portion of part corresponds respectively to the other end of the middle unloading pipe dish in each access through hole, and the rotation is chosen in pipe fitting
Provided with accommodating cavity, the accommodating cavity is used to house cryopreservation tube, and the rotation chooses pipe fitting and is used to drawing or discharging the cryopreservation tube；
Electric cylinders are rotated, the rotation electric cylinders are fixedly installed on second framework, and the rotation chooses pipe fitting and is arranged at the rotation
Turn in electric cylinders, the rotation electric cylinders are rotated for driving rotation to choose pipe fitting.
11. cryopreservation tube access device as claimed in claim 10, it is characterised in that the rotation, which is chosen, offers source of the gas on pipe fitting
Mouthful, and the port is connected with the accommodating cavity, and gas source connector is provided with the port, the gas source connector passes through logical
Tracheae is connected with source of the gas, and the source of the gas is used to carry out air inlet or air-breathing by the port.
12. cryopreservation tube access device as claimed in claim 10, it is characterised in that the quantity for arranging suction nozzle is 10, and access connects
The quantity of head is 12.
13. cryopreservation tube access device as claimed in claim 10, it is characterised in that described to rotate opening portion and the institute for choosing pipe fitting
State and sealed by encapsulant between unloading pipe dish.
14. cryopreservation tube access device as claimed in claim 1, it is characterised in that the cryopreservation tube control sub-component also includes
Second liquid nitrogen spray device, the second liquid nitrogen spray device are arranged on second framework.
15. cryopreservation tube access device as claimed in claim 14, it is characterised in that the cryopreservation tube control sub-component also includes
Second temperature sensor, the second temperature sensor are arranged on second framework, the second temperature sensor and institute
State the electrical connection of the second liquid nitrogen spray device.
16. the cryopreservation tube access device as described in any one in claim 1~15, it is characterised in that the cryopreservation tube is deposited
Device is taken also to include electric-control system, the electric-control system electrically connects with the cryopreservation tube access element.
17. the cryopreservation tube access device as described in any one in claim 1~15, it is characterised in that the shell is guarantor
Warm insulated shell.
18. cryopreservation tube access device as claimed in claim 1, it is characterised in that between every layer of placed side and the rotating disk
Angle is 45 degree.
19. cryopreservation tube access device as claimed in claim 1, it is characterised in that the drive component includes shaft coupling, plane
Bearing and motor, the shaft coupling are connected with the plane bearing and the motor respectively；
The bottom of the tank body is provided with axle sleeve, and one end of the central shaft is arranged in the axle sleeve, the central shaft it is another
End extends to outside the tank body and is connected with the plane bearing；
The motor is used to drive the shaft coupling to rotate.
20. cryopreservation tube access device as claimed in claim 1, it is characterised in that the opening is provided with leading truck；And/or
The opening is provided with fibre optical sensor, and the fibre optical sensor electrically connects with the drive component.
21. cryopreservation tube access device as claimed in claim 1, it is characterised in that the liquid nitrogen container also includes one or more
Limiting plate, the limiting plate are located at the top of the rotating disk, and are fixedly connected with the central shaft, on each limiting plate respectively
It is described to freeze erection and be placed in the clamping part provided with clamping part.
22. cryopreservation tube access device as claimed in claim 21, it is characterised in that the clamping part is parallel with the rotating disk to be set
Put, and the clamping part is provided with several through holes, it is described to freeze frame through the through hole and be carried on the rotating disk.
23. cryopreservation tube access device as claimed in claim 22, it is characterised in that the quantity of the limiting plate is 2；With/
Or, the quantity of the through hole is 81.
24. cryopreservation tube access device as claimed in claim 1, it is characterised in that described one end for freezing frame is provided with iron block.
25. cryopreservation tube access device as claimed in claim 1, it is characterised in that 10 placements are equipped with every layer of placed side
Groove, the standing groove are used to place cryopreservation tube.
26. the cryopreservation tube access device as described in any one in claim 18~25, it is characterised in that outside the tank body
Layer is vacuum heat-insulating layer.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610273913.XA CN105857932B (en) | 2016-04-28 | 2016-04-28 | Cryopreservation tube access device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610273913.XA CN105857932B (en) | 2016-04-28 | 2016-04-28 | Cryopreservation tube access device |
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| CN105857932A CN105857932A (en) | 2016-08-17 |
| CN105857932B true CN105857932B (en) | 2018-02-13 |
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| CN204973978U (en) * | 2015-06-24 | 2016-01-20 | 中国人民解放军总医院 | Test tube rack |
| CN105379706B (en) * | 2015-10-22 | 2018-01-16 | 上海原能细胞医学技术有限公司 | The automatic access control device of frozen cell |
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2016
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Application publication date: 20160817 Assignee: Shanghai primary cell biological low temperature Equipment Co Ltd Assignor: ORIGINCELL TECHNOLOGY GROUP CO., LTD.|SHANGHAI ORIGINCELL MEDICAL TECHNOLOGY CO., LTD.|Shanghai Original Health Management Co., Ltd. Contract record no.: 2018310000021 Denomination of invention: Cryogenic vial storing and fetching device Granted publication date: 20180213 License type: Exclusive License Record date: 20180611 |
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Effective date of registration: 20180628 Address after: No. 380, No. 380, Qu you road, Shanghai, Shanghai Patentee after: Shanghai primary cell biological low temperature Equipment Co Ltd Address before: 201299 C2873 room 24, 2 New Town Road, mud town, Pudong New Area, Shanghai Co-patentee before: SHANGHAI ORIGINCELL MEDICAL TECHNOLOGY CO., LTD. Patentee before: Shanghai Original Health Management Co., Ltd. Co-patentee before: ORIGINCELL TECHNOLOGY GROUP CO., LTD. |