CN105853691A

CN105853691A - Traditional Chinese medicine composition for treating fatty liver and preparation method thereof

Info

Publication number: CN105853691A
Application number: CN201610444150.0A
Authority: CN
Inventors: 李登
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-06-17
Filing date: 2016-06-17
Publication date: 2016-08-17

Abstract

The invention discloses a traditional Chinese medicine composition for treating fatty liver and a preparation method thereof. The composition is prepared from the following raw materials in parts by weight: 15-20 parts of garlic residues, 10-20 parts of rabdosia rubescens, 0.2-0.8 part of safrron, 5-8 parts of morinda parvifolia, 10-20 parts of fagopyrum tararicum, 4-12 parts of rhizoma alismatis, 2-6 parts of evodia lepta merr and 10-20 parts of tamarind fruits. The preparation method comprises the following steps: (1) soaking morinda parvifolia in a rice vinegar solution, drying and grinding to obtain fine powder; (2) preparing thick paste from garlic residues, rhizoma alismatis and evodia lepta merr by adopting an ethanol extraction method; (3) preparing thick paste from rabdosia rubescens, saffron, fagopyrum tararicum and tamarind fruits by adopting a water extraction method; and (4) preparing a finished product from the intermediate raw materials prepared in previous steps by adopting a conventional traditional Chinese medicine preparation technology. The traditional Chinese medicine composition has the effects of promoting qi circulation, eliminating blood stasis, strengthening spleen, tonifying lung, nourishing blood and yin, dispelling wind, inducing diuresis, soothing liver, promoting bile flow, lowering blood pressure and the like, has quick response, no toxic or side effect and relapse prevention, has a remarkable curative effect on fatty liver treatment, and is worthy of wide popularization and application.

Description

A kind of Chinese medicine composition treating fatty liver and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, a kind of Chinese medicine composition treating fatty liver and preparation method thereof.

Background technology

Fatty liver refers to the pathological changes that athero is too much in the hepatocyte caused by a variety of causes, in recent years, fat, glycosuria The prevalence of the affluenza such as disease, hyperlipidemia, hypertension raises year by year, causes the number that suffers from fatty liver to rise, normal liver Fat content be about the 3%～5% of liver mass, fatty liver can be formed more than 5%, be severe fatty liver more than 50%； The health of fatty liver disease positive serious threat compatriots, becomes the second largest hepatopathy being only second to viral hepatitis, has been acknowledged as hidden The common cause of covering property liver cirrhosis.

The diverse clinical manifestations of fatty liver, mild fatty liver is many without clinical symptoms, the most tired sense, and most Patients with Fatty Liver More fat, chance on when fatty liver patient is more than health check-up；In, severe fatty liver have the performance of similar chronic hepatitis, can have food Being intended to depressed, lassitude and weak, Nausea and vomiting, hepatic region or upper right abdomen dull pain etc., liver silght enlargement can have tenderness, and quality is slightly Tough, edge is blunt, smooth surface, a few patients can have splenomegaly and liver palm, when intrahepatic fat deposition too much time, liver quilt can be made Film expands, ligaments of liver tractive, and causes upper right abdomen to have an intense pain or tenderness, heating, numeration of leukocyte increase, and mistaken diagnosis be urgency Abdomen disease and make laparotomy ventrotomy；Severe fatty liver patient can have seroperitoneum and lower limbs edema, electrolyte disturbance, as low sodium, Hypokalemia etc..

Fatty liver belongs to reversibility disease, and early diagnosis is also treated in time and often can be recovered normal, at present, the treatment of doctor trained in Western medicine mainly with Blood fat reducing, protecting the liver, drop enzyme for main doctor then, but treatment time is long, less effective, life-time service has untoward reaction；The traditional Chinese medical science Treatment fatty liver reduces phlegm with depressed liver-energy dispersing and QI regulating, dissipating phlegm and removing blood stasis, soothing liver and strengthening spleen, damp eliminating, nourishing the kidney and liver, blood circulation promoting and blood stasis dispelling, heat clearing away Expectorant, benefiting QI for activating blood circulation, dispersing swelling and dissipating binds etc. are principle, have certain curative effect, have no side effect；But, sell in the market and control Treatment fatty liver medicament is various, but the real medicine that therapeutic effect is good, cost performance is high is the most few.

Summary of the invention

It is an object of the invention to provide a kind of depressed liver-energy dispersing and QI regulating, function of gallbladder promoting blood pressure lowering, blood circulation promoting and blood stasis dispelling, the Chinese medicine composition for the treatment of fatty liver Thing and preparation method thereof, with the problem solving to propose in above-mentioned background technology.

For achieving the above object, the present invention provides following technical scheme:

A kind of Chinese medicine composition treating fatty liver, is made up of according to the raw material of weight portion following: Bulbus Allii slag 15-20 part, winter insult Grass 10-20 part, Stigma Croci 0.2-0.8 part, Herba Morindae Parvifoliae 5-8 part, Radix Et Rhizoma Fagopyri Tatarici 10-20 part, Rhizoma Alismatis 4-12 part, three bifurcation hardships 2-6 Part, Fructus Tamarindi Indicae 10-20 part.

As the further scheme of the present invention: the Chinese medicine composition of described treatment fatty liver, by the raw material of following erection weight part Composition: Bulbus Allii slag 17 parts, Rabdosia rubescens 15 parts, Stigma Croci 0.5 part, Herba Morindae Parvifoliae 7 parts, Radix Et Rhizoma Fagopyri Tatarici 15 parts, Rhizoma Alismatis 8 parts, three Bifurcation bitter 4 parts, Fructus Tamarindi Indicae 15 parts.

The preparation method of the Chinese medicine composition of described treatment fatty liver, comprises the following steps:

1) Herba Morindae Parvifoliae weighing formula ratio is cleaned and cuts into slices, and is immersed in rice vinegar solution 3-5 hour, takes out and dry also after immersion Grind, cross 180-300 eye mesh screen, obtain fine powder standby；

2) weigh the Bulbus Allii slag of formula ratio, Rhizoma Alismatis, three bifurcation hardships put into extraction pot, add 75% ethanol with solid-liquid ratio 1:8-12 Solution, heating and refluxing extraction 2-3 time under the conditions of 40-50 DEG C, each 3-6 hour, filter and stand, reclaim ethanol and in The thick paste that relative density is 1.08-1.13 it is concentrated into standby under the conditions of 55 DEG C；

3) weigh the Rabdosia rubescens of formula ratio, Stigma Croci, Radix Et Rhizoma Fagopyri Tatarici and Fructus Tamarindi Indicae and add in extraction pot, add with solid-liquid ratio 1:6-12 Distilled water, boils and extracts 2-3 time, each 3-6 hour, filters after extracting every time, and merging filtrate is further in 55 DEG C of bars The thick paste that relative density is 1.08-1.13 it is concentrated into standby under part；

4) by the thick paste of preparation in the fine powder of preparation, step 2 in step 1 and the thick paste mixing of preparation in step 3, use Conventional Chinese medicine preparation technology makes Chinese medicine composition finished product.

As the present invention further scheme: in described step 1, in rice vinegar solution, acetate concentration is 5-15%.

As the present invention further scheme: in described step 2 and step 3, extraction time is 2 times, and each 4.5 Hour.

As the present invention further scheme: described Chinese medicine composition be prepared as treat the tablet of fatty liver, pill, powder, Capsule, granule, medicated wine, syrup, electuary or tincture.

In the present invention, the pharmacological action of each component is as follows:

1. Bulbus Allii slag: Bulbus Allii slag is the garbage after vapor distillation extracts Oleum Bulbus Allii, containing the necessary mineral of human body in Bulbus Allii slag Matter, multivitamin, 17 kinds of aminoacid, polypeptide and SOD, and except macroelement Ca, the Mg containing needed by human body, The content the most relatively horn of plenty of trace element Fe, Zn useful to human body, and Cu, Mu, the Co etc. containing needed by human； In Bulbus Allii slag, the content of organic germanium is three times in Radix Ginseng, has the strongest antibacterial, the antiinflammatory, sterilizing, blood fat reducing, blood pressure lowering energy Power, to arteriosclerosis, myocardial infarction, thrombosis, diabetes, antiviral, suppression platelet aggregation, anti-curing cancers and swollen Tumor, enhancing immunologic function, slow down aging have significant curative effect.

2. order in June: Labiatae Rabdosia, bitter in the mouth, sweet；Cold nature；Heat-clearing and toxic substances removing, promoting blood circulation and stopping pain；Cure mainly swelling throat Bitterly, headache due to common cold, tracheitis, chronic hepatitis, rheumatic arthritis, snake bite and insect sting；Have good heat clearing away poison, promoting blood circulation and stopping pain, Antibacterial, antitumor action；Rabdosia rubescens contains rubescensine A, rubescensine B and rosmarinic acid, and rubescensine A, winter insult Grass B prime has antitumaous effect, has obvious relief of symptoms effect to primary hepatocarcinoma, has stable and reduces tumor body and extend patient The effect of life；Rabdosia rubescens and chemotherapy, other cancer therapy drug partner treatment cancers have obvious potentiation；Good antimicrobial effect, The decoct of Rabdosia rubescens and alcohol agent can effectively suppress A type and beta hemolytic streptococcus, staphylococcus aureus etc., improve Human body resistance, reduces rapidly the leukocyte caused because of inflammation and increases.

3. Stigma Croci: sweet in the mouth, property are flat；Rich in carotene compounds, have crocin, bayer acid dimethyl ester, kind Flos Carthami hardship glycoside and safranal；For treating troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, spit blood, typhoid fever is gone mad, frightened fear in a trance, blood stasis Have a pain, measles, traumatic injury etc.；Be used as calm, carminative, have blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization effect, Cure mainly that maculae caused by violent heat pathogen, melancholy painful abdominal mass be vexed, palpitation with fear is gone mad；Having choleretic effect, crocetin can reduce cholesterol and increase fat Metabolism, by improving microcirculation, promotes secretion and the excretion of bile, thus reduces the abnormal globulin increased and total bilirubin, Can be used for the treatment of liver cirrhosis after chronic viral hepatitis, the early stage acute liver injury causing noxious substance has chemoprophylaxis to make With；Can be by blood circulation promoting and blood stasis dispelling, effect of anti-inflammation, enhancing body endurance, strengthen lymphproliferation response, improve machine Somatic cell immunity and humoral immunization.

4. Herba Morindae Parvifoliae: sweet in the mouth, pungent, slightly warm in nature；Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling；For few abdomen cold type of pain, rheumatic arthralgia, The soft lumbocrural pain of muscles and bones flaccidity of deficiency of the liver and kindey can also be treated；Containing anthraquinone, flavone compound, saccharide, vitamin C and Zinc, manganese, ferrum etc., have the effect significantly promoting adrenocortical hormone, and can strengthen hypothalamic-pituitary-ovarian rush Huang The function of body, has certain hypotensive effect；It is demonstrated experimentally that Herba Morindae Parvifoliae can increase hypothyroidism mice oxygen consumption, have The effect of suppression young mice atrophy of thymus gland.

5. Radix Et Rhizoma Fagopyri Tatarici: rich in proteins, fat, vitamin B2 and mineral nutrient element, possibly together with Radix Et Rhizoma Fagopyri Tatarici flavone, containing rutin, The aldehydes matters such as Quercetin, double-colored element, camphane phenanthrene alcohol, have vessel softening, improve microcirculation, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, Blood sugar lowering, urine glucose lowering, blood fat reducing, reinforcement insulin peripheral action；Radix Et Rhizoma Fagopyri Tatarici sugar alcohol declines in the effect of human body intestinal canal microorganism Solve DCI, improve the sensitivity of insulin, thus reduce animal and the blood glucose of human body, blood lipid level.

6. Rhizoma Alismatis: sweet in the mouth, light, cold in nature；Return kidney, bladder warp；Promoting diuresis to eliminate damp pathogen, expel the heat-evil, change turbid blood fat reducing；For urine not Profit, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia；Alisol A and Alisol A, B, The acetas of C has cholesterol reducing effect, also can protect the mouse liver because of carbon tetrachloride poisoning；The Rhizoma Alismatis alcohol that rubs can suppress The contraction of the Rabbit thoracic aorta caused by angiotensin, has slight hypotensive effect, can increase coronary flow.

7. three bifurcations are bitter: bitter in the mouth, cold in nature；Return liver, lung, stomach warp, there is the merit of heat-clearing and toxic substances removing, expelling wind and removing dampness, eliminating stasis to stop pain Effect；Containing steroidal saponin, saccharide, phenols, flavones ingredient, containing evolitrine, kokusaginine, dictamine and .beta.-fagarine； Containing volatile oil, it is mainly composed of australene, furfural；Herb contains left-handed edulinine；Treating the liver excess-heat, weakness and coldness of the liver labor Damage, treat laryngopharynx swelling and pain, malaria, icterohepatitis, rheumatic ostalgia.

8. Fructus Tamarindi Indicae: rich in sugar, acetic acid, tartaric acid, formic acid, citric acid, sweet mouthfeel, rich in proteins, fat is with thick Fiber content is few, rich in the multiple elements such as calcium, phosphorus, ferrum, nourishing the liver, promote the production of body fluid drive away summer heat, heat-clearing and toxic substances removing, elimination are had sore throat, Help digest, clean the teeth teeth consolidating；Diarrhoea, flatulence can be treated, prevent and treat vitamin C deficiency, polycholia, can kill parasite of human, Slow down alcoholism；Cytogenetics caused by ionizing radiation 60 ray is damaged and has repair, can be used for blood sugar lowering and fertilizer The auxiliary treatment of fat disease, can suppress lithangiuria etc. to be formed；Escherichia coli, dysentery bacterium and small intestinal are tied Enteritis yersinia all has inhibitory action, reduces the sickness rate that pathogenic entero becteria infects；There is mutation, radioprotective, prevent Cancer effect.

Compared with prior art, the invention has the beneficial effects as follows: the present invention uses natural Chinese prescription to be prepared from, each former Using the compatibility of science between material, meet Chinese medicine and pharmacy and modern medicine theory, drug effect complements each other, and makes the monarch and his subjects help all medicines Coordinating, negative and positive are taken mutually, and the exterior and the interior is helped each other, and has synergism, reaches circulation of qi promoting dissipating blood stasis, strengthening spleen and tonifying lung, nourishing the blood and yin, dispels the wind The effects such as dampness removing, soothing the liver circulation of qi promoting, function of gallbladder promoting blood pressure lowering, have significant curative effect to treatment fatty liver；Instant effect of the present invention, dosage form Various, have no side effect；Therapeutic effect is good, non-relapse after healing, it is possible to reach the purpose for the treatment of both the principal and secondary aspects of a disease, and total effective rate is high, It is widely popularized on clinic and applies.

Detailed description of the invention

Below in conjunction with detailed description of the invention, the technical scheme of this patent is described in more detail.

Embodiment 1

A kind of Chinese medicine composition treating fatty liver, is made up of according to the raw material of weight portion following: Bulbus Allii slag 15 parts, Rabdosia rubescens 10 parts, Stigma Croci 0.2 part, Herba Morindae Parvifoliae 5 parts, Radix Et Rhizoma Fagopyri Tatarici 10 parts, Rhizoma Alismatis 4 parts, three bifurcations bitter 2 parts, Fructus Tamarindi Indicae 10 parts.

Embodiment 2

A kind of Chinese medicine composition treating fatty liver, is made up of according to the raw material of weight portion following: Bulbus Allii slag 20 parts, Rabdosia rubescens 20 parts, Stigma Croci 0.8 part, Herba Morindae Parvifoliae 8 parts, Radix Et Rhizoma Fagopyri Tatarici 20 parts, Rhizoma Alismatis 12 parts, three bifurcations bitter 6 parts, Fructus Tamarindi Indicae 20 parts.

Embodiment 3

A kind of Chinese medicine composition treating fatty liver, is made up of according to the raw material of weight portion following: Bulbus Allii slag 16 parts, Rabdosia rubescens 13 parts, Stigma Croci 0.4 part, Herba Morindae Parvifoliae 6 parts, Radix Et Rhizoma Fagopyri Tatarici 13 parts, Rhizoma Alismatis 6 parts, three bifurcations bitter 3 parts, Fructus Tamarindi Indicae 13 parts.

Embodiment 4

A kind of Chinese medicine composition treating fatty liver, is made up of according to the raw material of weight portion following: Bulbus Allii slag 19 parts, Rabdosia rubescens 17 parts, Stigma Croci 0.6 part, Herba Morindae Parvifoliae 7 parts, Radix Et Rhizoma Fagopyri Tatarici 16 parts, Rhizoma Alismatis 9 parts, three bifurcations bitter 5 parts, Fructus Tamarindi Indicae 17 parts.

Embodiment 5

A kind of Chinese medicine composition treating fatty liver, is made up of according to the raw material of weight portion following: Bulbus Allii slag 17 parts, Rabdosia rubescens 15 parts, Stigma Croci 0.5 part, Herba Morindae Parvifoliae 7 parts, Radix Et Rhizoma Fagopyri Tatarici 15 parts, Rhizoma Alismatis 8 parts, three bifurcations bitter 4 parts, Fructus Tamarindi Indicae 15 parts.

The preparation method of the Chinese medicine composition of the treatment fatty liver described in embodiment 1-5, comprises the following steps:

1) Herba Morindae Parvifoliae weighing formula ratio is cleaned and cuts into slices, and is immersed in rice vinegar solution 3-5 hour, and in rice vinegar solution, acetic acid is dense Degree is 5-15%, takes out and dries and grind, cross 180-300 eye mesh screen, obtain fine powder standby after immersion；

2) weigh the Bulbus Allii slag of formula ratio, Rhizoma Alismatis, three bifurcation hardships put into extraction pot, add 75% ethanol with solid-liquid ratio 1:8-12 Solution, heating and refluxing extraction 2-3 time under the conditions of 40-50 DEG C, each 3-6 hour, filter and stand, reclaim ethanol and in The thick paste that relative density is 1.08-1.13 it is concentrated into standby, preferably heating and refluxing extraction 2 times under the conditions of 55 DEG C, each 4.5 little Time；

3) weigh the Rabdosia rubescens of formula ratio, Stigma Croci, Radix Et Rhizoma Fagopyri Tatarici and Fructus Tamarindi Indicae and add in extraction pot, add with solid-liquid ratio 1:6-12 Distilled water, boils and extracts 2-3 time, each 3-6 hour, filters after extracting every time, and merging filtrate is further in 55 DEG C of bars The thick paste that relative density is 1.08-1.13 it is concentrated into standby under part；Preferably extract twice, each 4.5 hours；

4) by the thick paste of preparation in the fine powder of preparation, step 2 in step 1 and the thick paste mixing of preparation in step 3, use Conventional Chinese medicine preparation technology makes Chinese medicine composition finished product, described Chinese medicine composition be prepared as treating the tablet of fatty liver, pill, Powder, capsule, granule, medicated wine, syrup, electuary or tincture.

1) animal toxicity test is carried out with the Chinese medicine composition of the embodiment of the present invention 5 preparation as follows:

1.1 test drugs: Chinese medicine composition of the present invention is added distilled water and is modulated into the magma of desired concn.

1.2 subjects: regular grade NIH mice, body weight 24g ± 2g, male and female half and half, female mice is all without pregnant；Commonly SD rat, original body mass 220 ± 15g, male and female half and half, female rats is all without pregnant；Laboratory animal is all tested from Peking University Animal center is bought.

2) acute toxicity test

Application mice carries out acute toxicity testing and shows: the medicine pill agent of the mouse stomach present invention, at 728.5g crude drug/kg Under dosage, after administration, mice occurs that light activity reduces, and within about 2 hours, recovers normal, Continuous Observation 7 days after administration, None dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal, test result indicate that: mice The maximum dosage-feeding of the Chinese medicine composition of the gavage present invention is 728.5g crude drug/kg/d (LD50 ＞ 728.5g crude drug/kg)； The Chinese medicine composition clinical application every day total amount of the present invention is 0.29g crude drug/kg/d；By weighing machine, in the mouse stomach present invention The dosis tolerata of drug composition is 2365.8 times of clinical patient, points out this medicine acute toxicity extremely low, clinical drug safety.

3) long term toxicity test

Select SD rat, give the medicine pill of the present invention of Three doses: 55.4g crude drug/kg, 19.2g crude drug/kg, 6.5g (, by 20 times of calculating of clinical application amount, clinical application amount is according to " the People's Republic of China (PRC) for per weight dosage for crude drug/kg Pharmacopeia " 2010 years versions one)；Every day gavage once, continuous 90 days, last be administered latter 24 hours respectively group live and kill 1/2 Animal (male and female half and half), remaining 1/2 animal lives after continuing to observe 2 weeks and kills；The outward appearance of animal, general is observed during test Behavior, food ration, body weight change；Be administered latter 90 days and drug withdrawal within 2 weeks, carry out hematology (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, the index checking such as organ coefficient histopathology.

Result of the test shows: the Chinese medicine composition of the present invention is good at high, medium and low dosage treated animal general state, outward appearance body Levy, behavioral activity, food-intake and body weight increase change the most without exception；Three dosage groups and matched group hematological examination, blood Biochemical, urine biochemical analysis all between normal range, group without significant difference；Each group main organs histopathological examination is not See obvious exception；These parameters drug withdrawal also have no after 2 weeks change, this test dosage be respectively clinical medicine dose 180, 60,20 times, according to result of the test: Chinese medicine preparation of the present invention is at high, medium and low three dosage (55.4g crude drug/kg, 19.2g Crude drug/kg, 6.5g crude drug/kg) continuous 90 days be administered rat is had no significant effect, without clear and definite toxicity target organ and sensitivity Index, convalescent period observation also has no retardance toxic reaction, the dosage safety of the Chinese medicine composition clinical practice of the prompting present invention Property is the highest.

The clinical trial of the present invention is as follows:

1. case selection: select 100 example patients to carry out clinical observation, patient age is in 30-55 year, and the course of disease is many at 2-3, 38 years old mean age, all there are uncomfortable liver area in various degree, abdominal distention, weak, dizzy, the nauseating and symptom such as uncomfortable of defecating, Confirm with the presence of fatty liver through ultrasound diagnosis.

2. medicament selection: treatment group patient takes the pill of the treatment fatty liver of the embodiment of the present invention 5 preparation, oral, every day 2 times, each two, 15 days be a course for the treatment of.

3. efficacy determination:

(1) cure: B ultrasonic display fatty liver disappears, rate and blood-lipid decreased to normal range, and liver function is normal, transference cure；

(2) effective: B ultrasonic display fatty liver degree alleviates, ALT declines ＞ 50%, rate and blood-lipid decreased ＞ 10%, and symptom takes a turn for the better；

(3) invalid: B ultrasonic display fatty liver degree unchanged, rate and blood-lipid decreased ＜ 10%, ALT declines ＜ 20%, symptom without Alleviate.

4. result: in 100 example patients, cures 88 examples, effective 9 examples, invalid 3 examples, and total effective rate is 97%.

5. model case citing:

Case 1: beam, man, 50 years old, suffer from fatty liver 3 years and have a surplus, period took multiple Drug therapy, and the state of an illness is the most anti- Multiple, the situation of hepatic region twinge occurs in the recent period, and with limbs fatigue, the symptom of inappetence, diagnoses through ultrasound diagnosis For fatty liver, and there is a small amount of ascites；Start to take syrup prepared by Chinese medicine composition of the present invention, three times a day, every time 30ml, after treating one month, patients symptomatic alleviates, and continuation medication treatment is after one month, and patient fully recovers, through ultrasound diagnosis, Display liver echo no abnormality seen, liver function recovery is normal；Following up a case by regular visits to after half a year, patient mental is full, has no that other is abnormal.

Case 2: Zhang, female, 45 years old, there is the sensation of the serious twinge in hepatic region in patient after drinking in the recent period, and ultrasound diagnosis diagnoses For mild fatty liver, start to take granule electuary prepared by Chinese medicine composition of the present invention upon somebody's introduction, every day 2 times, every time 1 bag, after treatment first quarter moon, the transference cure of hepatalgia, after the after treatment two weeks that continues to take medicine, through ultrasound diagnosis, suffer from Person's liver function is normal, and patient fully recovers.

Case 3: together certain, female, 60 years old, patient size was the fattest, suffered from fatty liver 3 years, period often occur the soreness of waist, Abdominal distention, the symptom of limbs fatigue, the symptom of hepatic region twinge occurs once in a while, be fatty liver after diagnosing；Start to take in the present invention Tablet prepared by drug composition, three times a day, each 2, after treating one month, patient's soreness of waist, abdominal distention, extremity are weary The symptom of power disappears substantially, and hepatic region is without uncomfortable sensation, and after continuing to take medicine one month, through ultrasound diagnosis, patient fully recovers, Physical recovery is normal, follows up a case by regular visits to without recurrence after 1 year.

Case 4: Liu so-and-so, man, 65 years old, the symptom of right flank pain occurs before patient's two weeks, and with abdominal distention, dizziness, The symptom that health is weak, during recent health check-up, ultrasound diagnosis patient suffers from fatty liver；Start to take Chinese medicine composition system of the present invention Standby capsule, every day 2 times, each 3, after two weeks of taking medicine, patient's abdominal distention, dizzy symptom has taken a turn for the better, After continuing to take medicine one month, patient mental is full, and without uncomfortable sensation, in order to thoroughly cure fatty liver, patient consolidates again and controls Treating two weeks, subsequently drug withdrawal, check that display fatty liver has disappeared, transaminase also recovers normal.

Case 5: Yan so-and-so, female, 63 years old, patient occur in the recent period retch, anorexia, abdominal distention, the soreness of waist, hepatic region twinge, four The symptom that limb is weak, is fatty liver on inspection, and transaminase increases as 45u/L；Start upon somebody's introduction to take Chinese drug-treated group of the present invention Pill prepared by compound, every day 2 times, each 2, after taking medicine one month, patients symptomatic is clearly better, and continues to take medicine one After individual month, patients symptomatic all disappears, and B ultrasonic shows liver's fat loss, and transaminase is 35u/L, suffers from for therapeutic outcome Person is the most satisfied, follows up a case by regular visits to patient without recurrence after 1 year.

Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, In the ken that those of ordinary skill in the art is possessed, it is also possible to make each on the premise of without departing from this patent objective Plant change.

Claims

1. the Chinese medicine composition treating fatty liver, it is characterised in that be made up of according to the raw material of weight portion following: Bulbus Allii slag 15-20 part, Rabdosia rubescens 10-20 part, Stigma Croci 0.2-0.8 part, Herba Morindae Parvifoliae 5-8 part, Radix Et Rhizoma Fagopyri Tatarici 10-20 part, Rhizoma Alismatis 4-12 Part, three bifurcation hardship 2-6 parts, Fructus Tamarindi Indicae 10-20 part.

The Chinese medicine composition for the treatment of fatty liver the most according to claim 1, it is characterised in that by following erection weight part Raw material composition: Bulbus Allii slag 17 parts, Rabdosia rubescens 15 parts, Stigma Croci 0.5 part, Herba Morindae Parvifoliae 7 parts, Radix Et Rhizoma Fagopyri Tatarici 15 parts, Rhizoma Alismatis 8 Part, three bifurcations bitter 4 parts, Fructus Tamarindi Indicae 15 parts.

3. the preparation method of the Chinese medicine composition of the treatment fatty liver as described in claim 1-2 is arbitrary, it is characterised in that Comprise the following steps:

The preparation method of the Chinese medicine composition for the treatment of fatty liver the most according to claim 3, it is characterised in that described step In rapid 1, in rice vinegar solution, acetate concentration is 5-15%.

The preparation method of the Chinese medicine composition for the treatment of fatty liver the most according to claim 3, it is characterised in that described step Rapid 2 and step 3 in, extraction time is 2 times, each 4.5 hours.

The preparation method of the Chinese medicine composition for the treatment of fatty liver the most according to claim 3, it is characterised in that in described Drug composition is prepared as treating the tablet of fatty liver, pill, powder, capsule, granule, medicated wine, syrup, electuary Or tincture.