CN105816836A - Traditional Chinese medicine preparation for treating interstitial pneumonia and application of traditional Chinese medicine preparation - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating interstitial pneumonia. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 15-20 parts of radix ophiopogonis, 15-20 parts of radix polygonati officinalis, 15-20 parts of fritillaria cirrhosa, 15-20 parts of flos farfarae, 10-15 parts of mongolian snake gourd roots, 10-15 parts of mulberry leaves, 10-15 parts of loquat leaves, 10-15 parts of turtle shell, 10-15 parts of platycodon grandiflorum, 10-15 parts of schizonepeta, 10-15 parts of ginger, 6-10 parts of radix stemonae, 6-10 parts of apricot kernel, 6-10 parts of pericarpium citri reticulatae, 6-10 parts of rhodiola rosea and 10-15 parts of raw liquorice. The traditional Chinese medicine preparation is applied to treatment of interstitial pneumonia; the conditions of lung rale, a cough, dyspnea, asthma and the like can be obviously improved; and the traditional Chinese medicine preparation is significant in treatment effect, free of an untoward effect and free of a toxic or side effect.

Description

A kind of Chinese medicine preparation treating interstitial pneumonia and application thereof

Technical field

The invention belongs to field of traditional Chinese, be specifically related to a kind of Chinese medicine preparation treating interstitial pneumonia and application thereof.

Background technology

2013 start, various places, China central and east occur successively on a large scale with long-time haze weather, the constituent of haze is considerably complicated, has a strong impact on the health of respiratory system.It is particulate that the mankind wherein endanger maximum, such as mineral grain thing, Organic aerosol particle, fuel and automobile exhaust gas etc., these materials enter into the human body by air borne, adhere to respiratory tract and pulmonary, stimulate respiratory tract, cause airway inflammation and tracheospasm, increase the weight of respiratory tract disease；Antibacterial, virus are attached on the little granule of PM2.5, quickly enter respiratory tract, and induction is infected.

The diffusivity substance pulmonary disease that interstitial pneumonia is a kind of burst and agnogenic interstitial tissue of lung occurs, mainly invades bronchial wall, alveolar wall, particularly between peribronchial, blood vessel lobule or the connective tissue of alveolar septum.Fall ill in the majority to be grown up, asexuality difference.Most patients has the symptom of similar upper respiratory tract infection at the onset initial stage, and heating, dry cough, can have purulent sputum during secondary infection suddenly；Have uncomfortable in chest, weak, cyanosis, stridulate, feeling of chest tightness, the dyspnea that companion's Progressive symmetric erythrokeratodermia increases the weight of.Pathogenesis is complex, may with virus etc. the infection of microorganism, the suction of organic dust, harmful gas stimulation relevant.This disease treatment difficulty, prognosis is poor.

Western medicine interstitial pneumonia is mainly based on glucocorticoid and immunosuppressant, but Therapeutic Method is more single, the comparison of ingredients of medicine is fixed, all of patient is nearly all to use a kind of Therapeutic Method, and the toxic and side effects of medicine is relatively big, long-term taking can produce dependency, even can induced Diabetic, hypertension, cataract, osteoporosis diseases, plus the medical expense of great number, and not all patient has affordability.From the point of view of the angle of the traditional Chinese medical science, interstitial pneumonia belongs to the categories such as cough, consumptive lung disease, the syndrome of dyspnea and pulmonary distension.Treatment by Chinese herbs interstitial pneumonia has the advantage of uniqueness, it is possible to effectively alleviate patient lungs's fibrosis, and medical expense is relatively low, has no adverse reaction and any toxic and side effects, can prolonged and repeated treat.

Summary of the invention

In order to solve the problems such as interstitial pneumonia treatment is difficult, prognosis is poor, it is an object of the invention to provide a kind of Chinese medicine preparation treating interstitial pneumonia and application thereof.

The present invention solves the technical scheme of its technical problem: a kind of Chinese medicine preparation treating interstitial pneumonia, it is characterized in that, by monarch drug, ministerial drug, adjuvant drug with make medicine form, wherein monarch drug is Radix Ophiopogonis, Rhizoma Polygonati Odorati, Bulbus Fritillariae Cirrhosae, Flos Farfarae, ministerial drug is Radix Trichosanthis, Folium Mori, Folium Eriobotryae, Carapax Trionycis, Radix Platycodonis, Herba Schizonepetae, Rhizoma Zingiberis Recens, adjuvant drug is the Radix Stemonae, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Radix Rhodiolae, and making medicine is Radix Glycyrrhizae；This Chinese medicine preparation is made up of the crude drug of following weight portion: Radix Ophiopogonis 15-20 part, Rhizoma Polygonati Odorati 15-20 part, Bulbus Fritillariae Cirrhosae 15-20 part, Flos Farfarae 15-20 part, Radix Trichosanthis 10-15 part, Folium Mori 10-15 part, Folium Eriobotryae 10-15 part, Carapax Trionycis 10-15 part, Radix Platycodonis 10-15 part, Herba Schizonepetae 10-15 part, Rhizoma Zingiberis Recens 10-15 part, Radix Stemonae 6-10 part, Semen Armeniacae Amarum 6-10 part, Pericarpium Citri Reticulatae 6-10 part, Radix Rhodiolae 6-10 part, Radix Glycyrrhizae 10-15 part.Wherein it is preferably: Radix Ophiopogonis 20 parts, Rhizoma Polygonati Odorati 20 parts, Bulbus Fritillariae Cirrhosae 20 parts, Flos Farfarae 20 parts, Radix Trichosanthis 15 parts, 15 parts of Folium Mori, Folium Eriobotryae 15 parts, Carapax Trionycis 15 parts, Radix Platycodonis 15 parts, Herba Schizonepetae 15 parts, 15 parts of Rhizoma Zingiberis Recens, the Radix Stemonae 10 parts, 10 parts of Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 10 parts, Radix Rhodiolae 10 parts, Radix Glycyrrhizae 15 parts.The Chinese medicine preparation of the present invention purposes in the medicine of preparation treatment interstitial pneumonia.

The effect of Chinese medicine of the present invention:

Radix Ophiopogonis, for the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Nature and flavor: hardship sweet, micro-, are slightly cold.GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst.

Rhizoma Polygonati Odorati, for the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati Polygonatum odoratum (Mill.) Druce.Nature and flavor: sweet in the mouth, property is put down.Attach to the lung and stomach meridians.Effect: nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.Hindering for lung stomach-Yin, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.

Bulbus Fritillariae Cirrhosae, for liliaceous plant Bulbus Fritillariae Cirrhosae Fritillaria cirrhosa D.Don, Fritillaria unibracteata Fritillaria unibracteata Hsiao et K.C.Hsia, Gansu Bulbus Fritillariae Uninbracteatae Fritillaria przewalskii Maxim. or the dry bulb of Bulbus Fritillariae cirrhosae Fritillaria delavayi Franch..Nature and flavor: bitter, sweet, are slightly cold.Return lung, heart channel.Effect: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.

Flos Farfarae, for the dry flower of feverfew coltsfoot Tussilago farfara L..Nature and flavor: hardship pungent, micro-, temperature.Return lung meridian.Effect: nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Cough for new chronic cough, dyspnea and cough with excessive sputum, chronic cough hemoptysis.

Radix Trichosanthis, for cucurbitaceous plant Fructus Trichosanthis Trichosanthes kirilowii Maxim. or the dry root of trichosanthes rosthornii Harms Trichosan-thes rosthornii Herms.Nature and flavor: hardship sweet, micro-, are slightly cold.Attach to the lung and stomach meridians.Effect: clearing away heat and promoting production of body fluid, moistening the lung and resolving phlegm, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst.

Folium Mori, for the dried leaves of moraceae plants Mulberry Morus alba L..Nature and flavor: bitter in the mouth, sweet, cold in nature.Return lung, Liver Channel.Effect: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.

Folium Eriobotryae, for rosaceous plant Folium Eriobotryae Eriobotrya The dried leaves of japonica (Thunb.) Lindl..Nature and flavor: bitter, are slightly cold.Attach to the lung and stomach meridians.Effect: clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastric heat vomiting, dysphoria with smothery sensation is thirsty.

Carapax Trionycis, for Trionychidae animal Trionyx sinensis Wiegmann Trionyx sinensis The carapace of Wiegmann.Nature and flavor: salty, cold.Return liver, kidney channel.Effect: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving.Cure mainly fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN.

Radix Platycodonis, for Campanulaceae Radix Platycodonis Platycodon grandiflorum(Jacq.) dry root of A.DC..Nature and flavor: bitter, pungent are flat.Return lung meridian.Effect: lung qi dispersing sore-throat relieving, evacuation of pus of eliminating the phlegm.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus.

Herba Schizonepetae, for the dry aerial parts of labiate Herba Schizonepetae Schizonepeta tenuifolia Briq..Nature and flavor: acrid in the mouth, micro-hardship are micro-wet.Return lung, Liver Channel.Effect: dispel the wind, induces sweat.Main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain.

Rhizoma Zingiberis Recens, for the fresh rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, tepor, return lung, spleen, stomach warp.Effect: relieving exterior syndrome and dispelling cold, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed.

The Radix Stemonae, for Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona Japonica (Bl.) Miq. or the dried root of radix stemonae tuberosae Stemona tuberosa Lour..Nature and flavor: sweet, bitter, tepor.Return lung meridian.Effect: nourishing the lung to keep the adverse QI downward cough-relieving.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis.

Semen Armeniacae Amarum, for rosaceous plant Prunus armeniaca L.var.ansu Maxim. (bitter Fructus Pruni) Prunus armeniaca L. var. ansu Maxim., Siberia Fructus Pruni (Prunus armeniaca L.var.ansu Maxim.) Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or the dry mature seed of Fructus Pruni Prunus armeniaca L..Nature and flavor: bitter, temperature, poisonous.Enter lung, spleen, large intestine channel.Effect: expelling phlegm for arresting cough, relievings asthma, intestine moistening.Control exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.

Pericarpium Citri Reticulatae, for rutaceae orange Citrus reticulata Blanco and the dry mature skin of variety thereof.Nature and flavor: bitter, pungent, temperature.Return lung, spleen channel.Effect: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Radix Rhodiolae, for the herb of crassulaceae plants full lobe Radix Rhodiolae.Nature and flavor: sweet, puckery, cold.Return lung meridian.Effect: clearing away lung-heat to relieve cough.For cough due to lung-heat, spitting of blood.

Radix Glycyrrhizae, for glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or the dry root of Glycyrrhiza glabra L. Glycyrrhiza glabra L..Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm.

The side of the present invention solves: Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire, Rhizoma Polygonati Odorati nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, Bulbus Fritillariae Cirrhosae clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, Flos Farfarae nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm, above four Chinese medicine, as monarch drug in side, all returns lung meridian, has the effect of nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing.From the point of view of the angle of the traditional Chinese medical science, primary disease belongs to the categories such as cough, consumptive lung disease, the syndrome of dyspnea and pulmonary distension, controls with nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing.With four Chinese medicine as monarch drug, the most fundamentally nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, make disease obtain basic control.Radix Trichosanthis clearing away heat and promoting production of body fluid, moistening the lung and resolving phlegm, detumescence and apocenosis, Folium Mori dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, Folium Eriobotryae clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI, Carapax Trionycis nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, Radix Platycodonis lung qi dispersing sore-throat relieving, evacuation of pus of eliminating the phlegm, Herba Schizonepetae is dispeled the wind, induces sweat, Rhizoma Zingiberis Recens relieving exterior syndrome and dispelling cold, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, ministerial drug in the above seven flavor medicine side of being.On the one hand auxiliary monarch drug nourishing YIN and moistening the lung, effect of preventing phlegm from forming and stopping coughing, on the other hand has lung heat clearing heat clearing away, the effect of evacuation of pus of eliminating the phlegm as ministerial drug.Radix Stemonae nourishing the lung to keep the adverse QI downward cough-relieving, Semen Armeniacae Amarum expelling phlegm for arresting cough, relieving asthma, intestine moistening, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, Radix Rhodiolae clearing away lung-heat to relieve cough, above four Chinese medicine is classified as adjuvant drug, can promote the monarch and his subjects two medicine nourishing YIN and moistening the lung, effect of preventing phlegm from forming and stopping coughing as adjuvant drug, can promote that again body regulating qi-flowing for strengthening spleen, dampness are relievingd asthma.Radix Glycyrrhizae, as making medicine in side, has the effect of coordinating the actions of various ingredients in a prescription, and all medicines of this side share, the monarch and his subjects pull together, assistant makes the most auxiliary, has nourishing YIN and moistening the lung, effect that preventing phlegm from forming and stopping coughing, lung heat clearing heat clearing away, evacuation of pus of eliminating the phlegm, regulating qi-flowing for strengthening spleen, dampness are relievingd asthma, it is possible to effectively treat interstitial pneumonia.

The Chinese medicine preparation of the treatment interstitial pneumonia of the present invention, its formula is made up of the crude drug of following weight portion: Radix Ophiopogonis 15-20 part, Rhizoma Polygonati Odorati 15-20 part, Bulbus Fritillariae Cirrhosae 15-20 part, Flos Farfarae 15-20 part, Radix Trichosanthis 10-15 part, Folium Mori 10-15 part, Folium Eriobotryae 10-15 part, Carapax Trionycis 10-15 part, Radix Platycodonis 10-15 part, Herba Schizonepetae 10-15 part, Rhizoma Zingiberis Recens 10-15 part, Radix Stemonae 6-10 part, Semen Armeniacae Amarum 6-10 part, Pericarpium Citri Reticulatae 6-10 part, Radix Rhodiolae 6-10 part, Radix Glycyrrhizae 10-15 part.

The Chinese medicine preparation preparation method of the present invention is: by the present invention each raw material medicines in portions by weight proportioning, taking each crude drug and be placed in marmite, add water dipped crude drug, overnight.Intense fire infusion 10-20 minute after overnight, fire infusion 30-40 minute of larding speech with literary allusions filtrate, merging gained filtrate after infusion 3-4 time repeatedly, both the decoction for the treatment of interstitial pneumonia of the present invention.Take decoction, take half an hour after meal in sooner or later.

The invention has the beneficial effects as follows: the raw material of the Chinese medicine preparation of the present invention is pure natural plant, safety non-toxic is cheap, easy to use.The all medicines in full side share has nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, lung heat clearing heat clearing away, effect that evacuation of pus of eliminating the phlegm, regulating qi-flowing for strengthening spleen, dampness are relievingd asthma, determined curative effect and safe and reliable, it is possible to be obviously improved the situations such as pulmonary's sound, cough, dyspnea and asthma.

Detailed description of the invention

Embodiment 1:

By each raw material medicines in portions by weight proportioning: Radix Ophiopogonis 20 parts, Rhizoma Polygonati Odorati 20 parts, Bulbus Fritillariae Cirrhosae 20 parts, Flos Farfarae 20 parts, Radix Trichosanthis 15 parts, 15 parts of Folium Mori, Folium Eriobotryae 15 parts, Carapax Trionycis 15 parts, Radix Platycodonis 15 parts, Herba Schizonepetae 15 parts, 15 parts of Rhizoma Zingiberis Recens, the Radix Stemonae 10 parts, 10 parts of Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 10 parts, Radix Rhodiolae 10 parts, Radix Glycyrrhizae 15 parts, capture medical herbs in marmite, add water dipped crude drug, overnight.Intense fire infusion 15 minutes after overnight, the fire infusion 30 minutes of larding speech with literary allusions filtrate, repeatedly merge gained filtrate after infusion 3 times, both the decoction for the treatment of interstitial pneumonia of the present invention.

70 example patients with interstitial pneumonia are randomly divided into treatment group and each 35 examples of matched group.Treatment group takes the present embodiment 1, takes decoction, sooner or later takes half an hour after meal.Matched group uses conventional western medicine Prednisone Therapy.

Efficacy assessment standard:

1) effective: after treating 10 days, the clinical symptom disappearance such as pulmonary's sound, cough, dyspnea and asthma, Thoracic CT scan inspection shows that laboratory and etiologic inspection are the most normal close to normal.

2) taking a turn for the better: after treating 10 days, the clinical symptoms such as pulmonary's sound, cough, dyspnea and asthma disappears substantially, and Thoracic CT scan inspection shows and is obviously improved, and laboratory and etiologic inspection also tend to normally.

3) invalid: after treating 10 days, the state of an illness is without significant change or deterioration.

Result is added up:

1 liang of table group patient outcomes compare

Group	Number of cases	Effective	Take a turn for the better	Invalid	Total effective rate (%)
						Treatment group	35	20	10	5	85.7
Matched group	35	15	12	8	77.1

Wherein, total effective rate=obvious effective rate+improvement rate.

By contrasting the treatment total effective rate of two groups of patients it appeared that treatment group is apparently higher than matched group.Thus illustrating, Chinese medicine preparation of the present invention has good clinical effectiveness in treatment interstitial pneumonia, can be effectively improved the cure rate for the treatment of, and effect is notable, cheap, has no adverse reaction and any toxic and side effects, has wide market application foreground.

Claims (3)

1. the Chinese medicine preparation treating interstitial pneumonia, it is characterized in that, by monarch drug, ministerial drug, adjuvant drug with make medicine form, wherein monarch drug is Radix Ophiopogonis, Rhizoma Polygonati Odorati, Bulbus Fritillariae Cirrhosae, Flos Farfarae, ministerial drug is Radix Trichosanthis, Folium Mori, Folium Eriobotryae, Carapax Trionycis, Radix Platycodonis, Herba Schizonepetae, Rhizoma Zingiberis Recens, adjuvant drug is the Radix Stemonae, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Radix Rhodiolae, and making medicine is Radix Glycyrrhizae；This Chinese medicine preparation is made up of the crude drug of following weight portion: Radix Ophiopogonis 15-20 part, Rhizoma Polygonati Odorati 15-20 part, Bulbus Fritillariae Cirrhosae 15-20 part, Flos Farfarae 15-20 part, Radix Trichosanthis 10-15 part, Folium Mori 10-15 part, Folium Eriobotryae 10-15 part, Carapax Trionycis 10-15 part, Radix Platycodonis 10-15 part, Herba Schizonepetae 10-15 part, Rhizoma Zingiberis Recens 10-15 part, Radix Stemonae 6-10 part, Semen Armeniacae Amarum 6-10 part, Pericarpium Citri Reticulatae 6-10 part, Radix Rhodiolae 6-10 part, Radix Glycyrrhizae 10-15 part.

A kind of Chinese medicine preparation treating interstitial pneumonia the most according to claim 1, it is characterized in that, this Chinese medicine preparation is made up of the crude drug of following weight portion: Radix Ophiopogonis 20 parts, Rhizoma Polygonati Odorati 20 parts, Bulbus Fritillariae Cirrhosae 20 parts, Flos Farfarae 20 parts, Radix Trichosanthis 15 parts, 15 parts of Folium Mori, Folium Eriobotryae 15 parts, Carapax Trionycis 15 parts, Radix Platycodonis 15 parts, Herba Schizonepetae 15 parts, 15 parts of Rhizoma Zingiberis Recens, the Radix Stemonae 10 parts, 10 parts of Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 10 parts, Radix Rhodiolae 10 parts, Radix Glycyrrhizae 15 parts.

A kind of Chinese medicine preparation treating interstitial pneumonia the most according to claim 1 and 2, it is characterised in that described Chinese medicine preparation purposes in the medicine of preparation treatment interstitial pneumonia.