CN105816519A - Pharmaceutical composition for treating emphysema and preparation method thereof - Google Patents
Pharmaceutical composition for treating emphysema and preparation method thereof Download PDFInfo
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- CN105816519A CN105816519A CN201610353305.XA CN201610353305A CN105816519A CN 105816519 A CN105816519 A CN 105816519A CN 201610353305 A CN201610353305 A CN 201610353305A CN 105816519 A CN105816519 A CN 105816519A
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- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention relates to a pharmaceutical composition for treating emphysema and a preparation method thereof .The pharmaceutical composition is prepared from, by weight, 10-50 parts of stalactite, 10-40 parts of radix angelicae pubescentis, 10-40 parts of radix phytolaccae, 20-60 parts of kudzuvine roots, 20-60 parts of honeysuckle stems, 15-45 parts of rhizoma bolbostemmae, 10-40 parts of rhizoma et radix notopterygii, 5-30 parts of benzoin, 10-40 parts of pericarpium trichosanthis, 10-40 parts of herba salviae chinensis and 10-45 parts of gallnuts .The pharmaceutical composition is prepared through water decocting and alcohol soaking processes .The pharmaceutical composition is used for treating 270 emphysema cases, the total effective rate reaches 94.4%, the effect is obvious, and no adverse reaction or toxic and side effect is found, so that it is proved that the pharmaceutical composition is significant in treatment effect on the emphysema and has the good popularization value.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to one treat emophysematous pharmaceutical composition and
Its preparation method.
Background technology
Emphysema refer to terminal bronchiole far-end (alveolar bronchiole, alveolar duct, alveolar sac and lung
Bubble) air flue elasticity attenuation, excessively expand, inflation and Pulmonary volume increase or break with airway walls simultaneously
Bad pathological state.Depending on clinical manifestation mild symptoms payes attention to emphysema degree.In early days can be asymptomatic or only
Feel to breathe hard when work, motion, be gradually difficult to competent original work.Along with emphysema are in progress,
Dyspnea degree increases the weight of therewith so that slightly movable or completely rest time still feel and breathing hard.The most still may be used
Feel weak, weight loss, loss of appetite, upper abdomen distension.It is slow for causing emophysematous main cause
Property bronchitis, therefore degasification is short outer also has the symptoms such as cough, expectoration, only has expiratory phase prolongation in early days
Or it is without exception.Typical case's emphysema person's thorax anteroposterior diameter increases, and in barrel chest, respiratory movement weakens, language
Sound trembles and weakens, percussion hyperresonant note, and border of cardiac dullness reduces, and liver dullness circle moves down, and respiratory murmur lowers,
Sometimes can hear dry, moist rale, increased heart rate, heart sound is low far, and P2 is hyperfunction.Lung
The complication that edema due to disorder of QI causes: 1, spontaneous pneumothorax, spontaneous pneumothorax is concurrently much in emphysema person,
Many because of ruptured pulmonary bulla under pleura, air leaks into caused by pleural space；2, respiratory failure, emphysema are often
Respiratory function is badly damaged, at some inducement such as dry and hard obstruction of respiratory tract infection, secretions, inappropriate
Under the influence of oxygen therapy, surgical operation etc., ventilation and dysfunction of ventilation increase the weight of further, can induce and exhale
Inhale exhaustion；3, chronic pulmonary heart disease, when emphysema are with hypoxemia and carbon dioxide retention,
Alveolar capillary bed destruction etc., all can cause pulmonary hypertension；In cardiac functional compensatory period, there is no the right side
Heart failure shows；4, gastric ulcer, emphysema patient can concurrent gastric ulcer；5, sleep disordered breathing,
In normal person's sleep, ventilation can be in a slight decrease, and when emphysema patient regains consciousness, ventilatory function has reduced.
Current medicine is cured the symptoms, not the disease, and conventional has dependency and side effect.Therefore research and development one
Plant the safely and effectively emophysematous Chinese medicine for the treatment of the most with practical value.
The present inventor, in order to solve the problems referred to above, have developed a kind of new drug.
Summary of the invention
It is an object of the invention to provide one and treat emophysematous pharmaceutical composition.
It is a further object of the present invention to provide a kind of preparation method treating emophysematous pharmaceutical composition.
The present invention provides one to treat emophysematous pharmaceutical composition, and this pharmaceutical composition is by following weight
The medicine of part is made: Stalactitum 10-50 part, Radix Angelicae Pubescentis 10-40 part, Radix Phytolaccae 10-40 part, Radix Puerariae 20-60
Part, Caulis Lonicerae 20-60 part, Rhizoma Bolbostematis 15-45 part, Rhizoma Et Radix Notopterygii 10-40 part, Benzoinum 5-30 part,
Pericarpium Trichosanthis 10-40 part, Herba Salviae Chinensis 10-40 part, Galla Chinensis 10-45 part.
Preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Stalactitum
15-45 part, Radix Angelicae Pubescentis 15-35 part, Radix Phytolaccae 15-35 part, Radix Puerariae 25-55 part, Caulis Lonicerae 25-55 part,
Rhizoma Bolbostematis 20-40 part, Rhizoma Et Radix Notopterygii 15-35 part, Benzoinum 10-25 part, Pericarpium Trichosanthis 15-35 part, stone
See and wear 15-35 part, Galla Chinensis 15-40 part.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following weight portion:
Stalactitum 20-40 part, Radix Angelicae Pubescentis 18-32 part, Radix Phytolaccae 18-32 part, Radix Puerariae 30-50 part, Caulis Lonicerae
30-50 part, Rhizoma Bolbostematis 22-38 part, Rhizoma Et Radix Notopterygii 18-32 part, Benzoinum 12-22 part, Pericarpium Trichosanthis 18-32
Part, Herba Salviae Chinensis 18-32 part, Galla Chinensis 20-35 part.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following weight portion:
Stalactitum 25-35 part, Radix Angelicae Pubescentis 20-30 part, Radix Phytolaccae 20-30 part, Radix Puerariae 35-45 part, Caulis Lonicerae
35-45 part, Rhizoma Bolbostematis 25-35 part, Rhizoma Et Radix Notopterygii 20-30 part, Benzoinum 15-20 part, Pericarpium Trichosanthis 20-30
Part, Herba Salviae Chinensis 20-30 part, Galla Chinensis 22-30 part.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following weight portion:
Stalactitum 30 parts, Radix Angelicae Pubescentis 25 parts, Radix Phytolaccae 25 parts, Radix Puerariae 40 parts, Caulis Lonicerae 40 parts, Rhizoma Bolbostematis
30 parts, Rhizoma Et Radix Notopterygii 25 parts, Benzoinum 18 parts, cortex trichosanthis 25 parts, Herba Salviae Chinensis 25 parts, Galla Chinensis 26 parts.
Pharmaceutical composition of the present invention is possibly together with pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention is solid preparation or liquid preparation, described solid preparation be tablet,
Capsule, granule or pill；Described liquid preparation is oral liquid.
The present invention carry arch a kind of preparation method treating emophysematous pharmaceutical composition, the method include with
Lower step:
By Stalactitum, Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, melon
Pericarpium Trichosanthis, Herba Salviae Chinensis, Galla Chinensis pulverize and sieve, and mix homogeneously with pharmaceutically acceptable carrier or diluent,
It is prepared as preparation.
The present invention carry arch a kind of preparation method treating emophysematous pharmaceutical composition, the method include with
Lower step:
1) weight portion medicine is weighed；
2) Stalactitum being ground into fine powder, the soak by water of addition 1-3 times amount 2-4 time, each 1-3 is little
Time, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds 75%
Ethanol 1-3 times soak 2-5 hour, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 4-6 times amount, decoct 3-5 time, each 2-4 hour, filter, and close
And filtrate, concentrate drying, it is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or
Diluent mix homogeneously, makes preparation.
Preferably, the present invention carry arch treat emophysematous pharmaceutical composition preparation method comprise the following steps:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 3 times of 2 times amount, each 2 hours, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 2 of 75%
Soak 3 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 5 times amount, decoct 4 times, each 3 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or
Diluent mix homogeneously, makes preparation.
Described parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of times amount refers to the weight ratio of medical material.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier that pharmaceutical field is conventional, choosing
One or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
Wherein said filler selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol,
Microcrystalline Cellulose or glucose etc.；
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
Described disintegrating agent selected from microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low take
For hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose；
Described lubricant selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, silicon dioxide,
Pulvis Talci or magnesium stearate；
Described surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, PULLRONIC F68
Copolymer, fatty acid Pyrusussuriensis be smooth or Polysorbate (tween) etc.；
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
The method have the advantages that
Treatment emphysema 270 example, patient mainly shows themselves in that emphysema, breathes hard, and health is weak, body
The heavily symptom such as decline, loss of appetite, taking pharmaceutical composition total effective rate of the present invention reaches 94.4%, effect
Substantially, and do not find untoward reaction and toxic and side effects, medicine composite for curing lung qi of the present invention is described
Swollen evident in efficacy, there is good promotional value.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription: Stalactitum 10g, Radix Angelicae Pubescentis 10g, Radix Phytolaccae 10g, Radix Puerariae 20g, Caulis Lonicerae 20g, Rhizoma Bolbostematis
Female 15g, Rhizoma Et Radix Notopterygii 10g, Benzoinum 5g, Pericarpium Trichosanthis 10g, Herba Salviae Chinensis 10g, Galla Chinensis 10g.
Preparation method:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 2 times of 1 times amount, each 1 hour, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 1 of 75%
Soak 2 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 4 times amount, decoct 3 times, each 2 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, load capsule, make capsule.
Embodiment 2
Prescription: Stalactitum 50g, Radix Angelicae Pubescentis 40g, Radix Phytolaccae 40g, Radix Puerariae 60g, Caulis Lonicerae 60g, Rhizoma Bolbostematis
Female 45g, Rhizoma Et Radix Notopterygii 40g, Benzoinum 30g, Pericarpium Trichosanthis 40g, Herba Salviae Chinensis 40g, Galla Chinensis 45g.
Preparation method:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 4 times of 3 times amount, each 3 hours, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 3 of 75%
Soak 5 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 6 times amount, decoct 5 times, each 4 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, load capsule, make capsule.
Embodiment 3
Prescription: Stalactitum 15g, Radix Angelicae Pubescentis 15g, Radix Phytolaccae 15g, Radix Puerariae 25g, Caulis Lonicerae 25g, Rhizoma Bolbostematis
Female 20g, Rhizoma Et Radix Notopterygii 15g, Benzoinum 10g, Pericarpium Trichosanthis 15, Herba Salviae Chinensis 15g, Galla Chinensis 15g.
Preparation method:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 3 times of 2 times amount, each 2 hours, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 2 of 75%
Soak 3 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 5 times amount, decoct 4 times, each 3 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, tabletting, obtain the tablet of the application.
Embodiment 4
Prescription: Stalactitum 45g, Radix Angelicae Pubescentis 35g, Radix Phytolaccae 35g, Radix Puerariae 55g, Caulis Lonicerae 55g, Rhizoma Bolbostematis
Female 40g, Rhizoma Et Radix Notopterygii 35g, Benzoinum 25g, Pericarpium Trichosanthis 35g, Herba Salviae Chinensis 35g, Galla Chinensis 40g.
Preparation method:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 3 times of 2 times amount, each 2 hours, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 2 of 75%
Soak 4 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 5 times amount, decoct 4 times, each 3 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, be dried, tabletting, obtain the tablet of the application.
Embodiment 5
Prescription: Stalactitum 20g, Radix Angelicae Pubescentis 18g, Radix Phytolaccae 18g, Radix Puerariae 30g, Caulis Lonicerae 30g, Rhizoma Bolbostematis
Female 22g, Rhizoma Et Radix Notopterygii 18g, Benzoinum 12g, Pericarpium Trichosanthis 18g, Herba Salviae Chinensis 18g, Galla Chinensis 20g.
Preparation method:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 3 times of 2 times amount, each 2 hours, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 2 of 75%
Soak 3 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 5 times amount, decoct 4 times, each 3 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, be dried, tabletting, obtain the tablet of the application.
Embodiment 6
Prescription: Stalactitum 40g, Radix Angelicae Pubescentis 32g, Radix Phytolaccae 32g, Radix Puerariae 50g, Caulis Lonicerae 50g, Rhizoma Bolbostematis
Female 38g, Rhizoma Et Radix Notopterygii 32g, Benzoinum 22g, Pericarpium Trichosanthis 32g, Herba Salviae Chinensis 32g, Galla Chinensis 35g.
Preparation method:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 3 times of 2 times amount, each 2 hours, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 2 of 75%
Soak 3 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 5 times amount, decoct 4 times, each 3 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight
The starch of 1/5, mixing, pelletize, be dried, granulate, obtain the granule of the application.
Embodiment 7
Prescription: Stalactitum 25g, Radix Angelicae Pubescentis 20g, Radix Phytolaccae 20g, Radix Puerariae 35g, Caulis Lonicerae 35g, Rhizoma Bolbostematis
Female 25g, Rhizoma Et Radix Notopterygii 20-30g, Benzoinum 15-20g, Pericarpium Trichosanthis 20-30g, Herba Salviae Chinensis 20-30g, five
Gall nut 22-30g.
Preparation method:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 3 times of 2 times amount, each 2 hours, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 2 of 75%
Soak 3 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 5 times amount, decoct 4 times, each 3 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, be dried, tabletting, obtain the tablet of the application.
Embodiment 8
Prescription: Stalactitum 35g, Radix Angelicae Pubescentis 30g, Radix Phytolaccae 30g, Radix Puerariae 45g, Caulis Lonicerae 45g, Rhizoma Bolbostematis
Female 35g, Rhizoma Et Radix Notopterygii 30g, Benzoinum 20g, Pericarpium Trichosanthis 30g, Herba Salviae Chinensis 30g, Galla Chinensis 30g.
Preparation method:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 3 times of 2 times amount, each 2 hours, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 2 of 75%
Soak 3 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 5 times amount, decoct 4 times, each 3 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight
The starch of 1/5, mixing, pelletize, be dried, granulate, obtain the granule of the application.
Embodiment 9
Prescription: Stalactitum 30g, Radix Angelicae Pubescentis 25g, Radix Phytolaccae 25g, Radix Puerariae 40g, Caulis Lonicerae 40g, Rhizoma Bolbostematis
Female 30g, Rhizoma Et Radix Notopterygii 25g, Benzoinum 18g, Pericarpium Trichosanthis 25g, Herba Salviae Chinensis 25g, Galla Chinensis 26g.
Preparation method:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 3 times of 2 times amount, each 2 hours, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 2 of 75%
Soak 3 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 5 times amount, decoct 4 times, each 3 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add and account for mix homogeneously fine powder weight 1/5
Starch, mixing, pelletize, be dried, granulate, obtain the granule of the application.
In order to sketch beneficial effects of the present invention further, inventor has done clinical trial, specific as follows:
One, physical data: inventor's in June, 2005 in December ,-2015 collects 270 example emphysema patient altogether,
The maleest 160 examples, female 110 example.It is randomly divided into 9 groups.The data such as two groups of sexes, age, state of an illness are equal
There was no significant difference, there is comparability.
Two, test method: 9 groups of pharmaceutical compositions that embodiment of the present invention 1-9 is administered orally respectively, a 4g,
One day 3 times, 4 weeks be a course for the treatment of.
Three, criterion of therapeutical effect and therapeutic outcome
1, criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears.
Effective: clinical symptoms disappears substantially.
Effective: clinical symptom relief.
Invalid: clinical symptoms is without being clearly better or increasing the weight of.
2, experimental result
Most patients is using medicine within about 2 weeks, to have significantly sensation according to the inventive method,
Emphysema, breathe hard, and the symptom such as health is weak, weight loss, loss of appetite has alleviated, and continue clothes
With 1-3 the course for the treatment of, effect such as following table:
| Group | Clinical recovery | Effective | Effectively | Invalid | Add up to | Effective percentage (%) |
| Embodiment 1 | 13 | 7 | 9 | 1 | 30 | 96.7% |
| Embodiment 2 | 14 | 6 | 9 | 1 | 30 | 96.7% |
| Embodiment 3 | 15 | 5 | 8 | 2 | 30 | 93.3% |
| Embodiment 4 | 14 | 7 | 8 | 1 | 30 | 96.7% |
| Embodiment 5 | 13 | 9 | 6 | 2 | 30 | 93.3% |
| Embodiment 6 | 16 | 8 | 4 | 2 | 30 | 93.3% |
| Embodiment 7 | 13 | 9 | 5 | 3 | 30 | 90.0% |
| Embodiment 8 | 17 | 7 | 5 | 1 | 30 | 96.7% |
| Embodiment 9 | 15 | 9 | 4 | 2 | 30 | 93.3% |
Treatment emphysema 270 example, total effective rate reaches 94.4%, and effect is obvious, and do not find bad instead
Should illustrate that medicine composite for curing emphysema of the present invention are evident in efficacy with toxic and side effects, have and well push away
Wide value.
Four, model case:
1, certain female: 48 years old, symptom: emphysema, weight loss, to breathe hard, health is weak, with coughing
Cough, take the embodiment of the present invention 1 preparation pharmaceutical composition, a 4g, one day 3 times, after taking 2 weeks,
Emphysema disease gradually alleviates, and cough symptom alleviates, and symptom of breathing hard alleviates；After continuing to take 2 months,
Emphysema persistent ailment is cured, and without recurrence, body constitution is recovered.
2, certain female, 43 years old, symptom: emphysema, with cough, the symptom of expectoration, breathe hard, muddy
Body is weak, takes the pharmaceutical composition of the embodiment of the present invention 2 preparation, a 4g, one day 3 times, takes 1
After individual month, emphysema disease gradually alleviates, remission of coughing；After continuing to take January, brokenk wind
Disease is dispelled, and cough, expectoration symptom alleviate；After taking 1 month again, emphysema persistent ailment is cured, without recurrence,
Body constitution is recovered, honey stomach.
3, certain female, 38 years old, symptom: emphysema, breathe weak after motion, under loss of appetite, body weight
Fall.Treatment: take the pharmaceutical composition of the embodiment of the present invention 3 preparation, a 4g, one day 3 times, take
After 1 month, breathing weak alleviation after motion, emphysema disease gradually alleviates；Adhere to continuing to take 2
After Yue, emphysema persistent ailment is cured, and appetite is recovered, and body constitution improves.
4, certain man, 62 years old, symptom: emphysema, weight loss, have a delicate constitution, movable or have a rest
Time breathe hard, with expectoration symptom.Treatment: take the embodiment of the present invention 4 preparation pharmaceutical composition, one
Secondary 4g, one day 3 times, after taking 1 month, expectoration, remission of breathing hard；After continuing to take 1 month,
Emphysema disease is dispelled, and expectoration symptom alleviates, and body constitution is gradually recovered；After continuing to take 1 month, lung qi
Swollen persistent ailment is cured, and emphysema are recovered without recurrence, body constitution.
5, certain female, 70 years old.Symptom: aging-lung emphysema, time breathe hard, breathe weight, body weight
Decline, appetite low.Take the embodiment of the present invention 5 preparation pharmaceutical composition, a 4g, one day 3 times,
After taking 2 months, emphysema disease is dispelled, and body constitution is gradually recovered, and symptom of breathing hard alleviates；Continue clothes
After 1 month, emphysema persistent ailment is cured, and emphysema are recovered without recurrence, body constitution, breathes normal.
6, certain man, 55 years old, symptom: emphysema, have a delicate constitution, appetite is low, movable or rest time
Breathe hard, treatment: take the pharmaceutical composition of the embodiment of the present invention 6 preparation, a 4g, a day 3 times, imitate
Really: after taking 3 months, emphysema disease is dispelled, and appetite is recovered, and body constitution is gradually recovered.
7, certain female: 44 years old, symptom: emphysema, with cough, the symptom of expectoration, breathe hard, the most weary
Power, take the embodiment of the present invention 7 preparation pharmaceutical composition, a 4g, one day 3 times, after taking 4 weeks,
Emphysema disease gradually alleviates, and cough symptom alleviates, and symptom of breathing hard alleviates；After continuing to take 3 months,
Emphysema persistent ailment is cured, and without recurrence, body constitution is recovered.
8, certain female, 42 years old, symptom: emphysema, breathe weak after motion, under loss of appetite, body weight
Fall.Treatment: take the pharmaceutical composition of the embodiment of the present invention 8 preparation, a 4g, one day 3 times, take
After 1 month, breathing weak alleviation after motion, emphysema disease gradually alleviates；Adhere to taking continuously 1.5
After individual month, emphysema persistent ailment is cured, and appetite is recovered, and body constitution improves.
9, certain female, 65 years old, symptom: emphysema, loss of appetite, have a delicate constitution, movable or rest time
Breathe hard, treatment: take the embodiment of the present invention 9 preparation pharmaceutical composition, a 4g, one day 3 times,
After taking 1 month, expectoration, remission of breathing hard；After continuing to take 1 month, emphysema disease is dispelled,
Expectoration symptom alleviates, and body constitution is gradually recovered；After continuing to take 1 month, emphysema persistent ailment is cured, lung qi
Swollen without recurrence, body constitution is recovered.
Although, used general explanation, detailed description of the invention and test, the present invention made
Detailed description, but on the basis of the present invention, it can be made some amendments or improve, this is right
It is apparent from for those skilled in the art.Therefore, without departing from theon the basis of the spirit of the present invention
These modifications or improvements, belong to the scope of protection of present invention.
Claims (10)
1. treat emophysematous pharmaceutical composition for one kind, it is characterised in that this pharmaceutical composition is by following heavy
The medicine of amount part is made: Stalactitum 10-50 part, Radix Angelicae Pubescentis 10-40 part, Radix Phytolaccae 10-40 part, Radix Puerariae
20-60 part, Caulis Lonicerae 20-60 part, Rhizoma Bolbostematis 15-45 part, Rhizoma Et Radix Notopterygii 10-40 part, Benzoinum 5-30
Part, Pericarpium Trichosanthis 10-40 part, Herba Salviae Chinensis 10-40 part, Galla Chinensis 10-45 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that this pharmaceutical composition by with
The medicine of lower weight portion is made: Stalactitum 15-45 part, Radix Angelicae Pubescentis 15-35 part, Radix Phytolaccae 15-35 part,
Radix Puerariae 25-55 part, Caulis Lonicerae 25-55 part, Rhizoma Bolbostematis 20-40 part, Rhizoma Et Radix Notopterygii 15-35 part, rest in peace
Fragrant 10-25 part, Pericarpium Trichosanthis 15-35 part, Herba Salviae Chinensis 15-35 part, Galla Chinensis 15-40 part.
Pharmaceutical composition the most according to claim 2, it is characterised in that this pharmaceutical composition by
The medicine of following weight portion is made: Stalactitum 20-40 part, Radix Angelicae Pubescentis 18-32 part, Radix Phytolaccae 18-32 part,
Radix Puerariae 30-50 part, Caulis Lonicerae 30-50 part, Rhizoma Bolbostematis 22-38 part, Rhizoma Et Radix Notopterygii 18-32 part, rest in peace
Fragrant 12-22 part, Pericarpium Trichosanthis 18-32 part, Herba Salviae Chinensis 18-32 part, Galla Chinensis 20-35 part.
Pharmaceutical composition the most according to claim 3, it is characterised in that this pharmaceutical composition by with
The medicine of lower weight portion is made: Stalactitum 25-35 part, Radix Angelicae Pubescentis 20-30 part, Radix Phytolaccae 20-30 part,
Radix Puerariae 35-45 part, Caulis Lonicerae 35-45 part, Rhizoma Bolbostematis 25-35 part, Rhizoma Et Radix Notopterygii 20-30 part, rest in peace
Fragrant 15-20 part, Pericarpium Trichosanthis 20-30 part, Herba Salviae Chinensis 20-30 part, Galla Chinensis 22-30 part.
Pharmaceutical composition the most according to claim 4, it is characterised in that this pharmaceutical composition by with
The medicine of lower weight portion is made: Stalactitum 30 parts, Radix Angelicae Pubescentis 25 parts, Radix Phytolaccae 25 parts, Radix Puerariae 40 parts,
Caulis Lonicerae 40 parts, Rhizoma Bolbostematis 30 parts, Rhizoma Et Radix Notopterygii 25 parts, Benzoinum 18 parts, Pericarpium Trichosanthis 25 parts, stone
See and wear 25 parts, Galla Chinensis 26 parts.
6. according to the pharmaceutical composition described in any one of claim 1-5, it is characterised in that this medicine
Compositions is possibly together with pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition the most according to claim 6, it is characterised in that described pharmaceutical composition
For solid preparation or liquid preparation, described solid preparation is tablet, capsule, granule or pill；
Described liquid preparation is oral liquid.
8. the method preparing pharmaceutical composition described in any one of claim 1-5, its feature exists
In, the method comprises the following steps:
By Stalactitum, Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, melon
Pericarpium Trichosanthis, Herba Salviae Chinensis, Galla Chinensis pulverize and sieve, and mix homogeneously with pharmaceutically acceptable carrier or diluent,
It is prepared as preparation.
9. prepare the method for pharmaceutical composition described in any one of claim 1-5 for one kind, it is characterised in that
The method comprises the following steps:
1) weight portion medicine is weighed；
2) Stalactitum being ground into fine powder, the soak by water of addition 1-3 times amount 2-4 time, each 1-3 is little
Time, collecting decoction, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds 75%
Ethanol 1-3 times soak 2-5 hour, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 4-6 times amount, decoct 3-5 time, each 2-4 hour, filter, and close
And filtrate, concentrate drying, it is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or
Diluent mix homogeneously, makes preparation.
The preparation method of pharmaceutical composition the most according to claim 9, it is characterised in that the party
Method comprises the following steps:
1) weight portion medicine is weighed；
2) Stalactitum is ground into fine powder, adds the soak by water 3 times of 2 times amount, each 2 hours, close
And decocting liquid, filter, filtrate concentrate drying, be ground into fine powder, standby；Filtering residue adds the ethanol 2 of 75%
Soak 3 hours again, filter, filtrate concentrate drying, be ground into fine powder, standby；
3) by Radix Angelicae Pubescentis, Radix Phytolaccae, Radix Puerariae, Caulis Lonicerae, Rhizoma Bolbostematis, Rhizoma Et Radix Notopterygii, Benzoinum, Pericarpium Trichosanthis,
Herba Salviae Chinensis, Galla Chinensis add the water of 5 times amount, decoct 4 times, each 3 hours, filter, merging filtrate,
Concentrate drying, is ground into fine powder, standby；
4) by step 2), 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or
Diluent mix homogeneously, makes preparation.
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