CN105814072A - 一种五环三萜结构修饰化合物及其制备方法和应用 - Google Patents
一种五环三萜结构修饰化合物及其制备方法和应用 Download PDFInfo
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- CN105814072A CN105814072A CN201480065401.3A CN201480065401A CN105814072A CN 105814072 A CN105814072 A CN 105814072A CN 201480065401 A CN201480065401 A CN 201480065401A CN 105814072 A CN105814072 A CN 105814072A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
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- Dermatology (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及一种五环三萜结构修饰化合物及其制备方法和应用,本发明的化合物能够有效地治疗银屑病。并且,本发明的化合物能选择性抑制TH1和TH17细胞的体外分化,从而可应用于治疗TH1和TH17介导的自身免疫性疾病。
Description
PCT国内申请,说明书已公开。
Claims (12)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013106233142 | 2013-11-30 | ||
CN201310623314.2A CN104672293B (zh) | 2013-11-30 | 2013-11-30 | 一种五环三萜结构修饰化合物及其制备方法和应用 |
PCT/CN2014/091371 WO2015078321A1 (zh) | 2013-11-30 | 2014-11-18 | 一种五环三萜结构修饰化合物及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
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CN105814072A true CN105814072A (zh) | 2016-07-27 |
CN105814072B CN105814072B (zh) | 2018-08-24 |
Family
ID=53198355
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CN201310623314.2A Active CN104672293B (zh) | 2013-11-30 | 2013-11-30 | 一种五环三萜结构修饰化合物及其制备方法和应用 |
CN201480065401.3A Active CN105814072B (zh) | 2013-11-30 | 2014-11-18 | 一种五环三萜结构修饰化合物及其制备方法和应用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CN201310623314.2A Active CN104672293B (zh) | 2013-11-30 | 2013-11-30 | 一种五环三萜结构修饰化合物及其制备方法和应用 |
Country Status (6)
Country | Link |
---|---|
US (1) | US9725482B2 (zh) |
EP (1) | EP3075739B1 (zh) |
JP (1) | JP6289659B2 (zh) |
CN (2) | CN104672293B (zh) |
DK (1) | DK3075739T3 (zh) |
WO (1) | WO2015078321A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104672293B (zh) * | 2013-11-30 | 2017-01-18 | 苏州博创园生物医药科技有限公司 | 一种五环三萜结构修饰化合物及其制备方法和应用 |
CN106674323B (zh) * | 2015-11-05 | 2019-10-22 | 苏州博创园生物医药科技有限公司 | 具有acc1蛋白调控作用的五环三萜类化合物及其用途 |
CN108358990B (zh) * | 2017-01-26 | 2021-04-20 | 苏州博创园生物医药科技有限公司 | 一种具有抗菌活性的五环三萜类化合物 |
CN110818767B (zh) * | 2018-08-13 | 2022-06-07 | 江苏博创园生物医药科技有限公司 | 3-O-环己甲酰基-11-羰基-β-乳香酸或其类似物的制备及纯化方法 |
WO2022228352A1 (zh) * | 2021-04-25 | 2022-11-03 | 江苏博创园生物医药科技有限公司 | 一种五环三萜类化合物结晶及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101724004A (zh) * | 2008-10-22 | 2010-06-09 | 王宏林 | 一种抗牛皮癣纯天然新药(11-羰基-β-乙酰乳香酸) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002085921A2 (de) * | 2001-03-01 | 2002-10-31 | Johann Jauch | Einfaches verfahren zur synthese von boswelliasäuren und derivaten davon |
KR100496776B1 (ko) | 2001-06-21 | 2005-06-22 | 삼성토탈 주식회사 | 에틸렌 중합 및 공중합용 촉매 |
US20030199581A1 (en) | 2002-03-13 | 2003-10-23 | Seligson Allen L. | Boswellin compositions enhanced with 3-beta-acetyl-11-keto-beta-boswellic acid ("AKBA") industrial manufacture and uses |
US8748598B2 (en) * | 2004-06-18 | 2014-06-10 | Laila Nutraceuticals | Analogs of 3-O-acetyl-11-keto-beta-boswellic acid |
GB0604899D0 (en) * | 2006-03-10 | 2006-04-19 | York Pharma Plc | Derivatives of 18-glycyrrhetinic acid |
CN101775058B (zh) * | 2009-01-08 | 2012-07-18 | 凌沛学 | 一种从乳香中提取的11-羰基-β-乙酰乳香酸及其衍生物的药物制剂的制备和应用 |
CN104672293B (zh) * | 2013-11-30 | 2017-01-18 | 苏州博创园生物医药科技有限公司 | 一种五环三萜结构修饰化合物及其制备方法和应用 |
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2013
- 2013-11-30 CN CN201310623314.2A patent/CN104672293B/zh active Active
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2014
- 2014-11-18 JP JP2016555881A patent/JP6289659B2/ja active Active
- 2014-11-18 WO PCT/CN2014/091371 patent/WO2015078321A1/zh active Application Filing
- 2014-11-18 EP EP14865408.0A patent/EP3075739B1/en active Active
- 2014-11-18 US US15/100,076 patent/US9725482B2/en active Active
- 2014-11-18 DK DK14865408.0T patent/DK3075739T3/en active
- 2014-11-18 CN CN201480065401.3A patent/CN105814072B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101724004A (zh) * | 2008-10-22 | 2010-06-09 | 王宏林 | 一种抗牛皮癣纯天然新药(11-羰基-β-乙酰乳香酸) |
Non-Patent Citations (1)
Title |
---|
AJAY KUMAR ET AL.: "Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
Also Published As
Publication number | Publication date |
---|---|
CN104672293A (zh) | 2015-06-03 |
US9725482B2 (en) | 2017-08-08 |
US20170002039A1 (en) | 2017-01-05 |
EP3075739A4 (en) | 2017-08-02 |
WO2015078321A1 (zh) | 2015-06-04 |
EP3075739A1 (en) | 2016-10-05 |
DK3075739T3 (en) | 2018-12-03 |
CN104672293B (zh) | 2017-01-18 |
JP6289659B2 (ja) | 2018-03-07 |
CN105814072B (zh) | 2018-08-24 |
JP2016538346A (ja) | 2016-12-08 |
EP3075739B1 (en) | 2018-10-17 |
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