CN105797206A - Biomedical composite implant material and preparing method thereof - Google Patents
Biomedical composite implant material and preparing method thereof Download PDFInfo
- Publication number
- CN105797206A CN105797206A CN201610141352.8A CN201610141352A CN105797206A CN 105797206 A CN105797206 A CN 105797206A CN 201610141352 A CN201610141352 A CN 201610141352A CN 105797206 A CN105797206 A CN 105797206A
- Authority
- CN
- China
- Prior art keywords
- composite
- powder
- implant
- bio
- ball
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002131 composite material Substances 0.000 title claims abstract description 82
- 239000000463 material Substances 0.000 title claims abstract description 68
- 239000007943 implant Substances 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims abstract description 25
- 239000000843 powder Substances 0.000 claims abstract description 75
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 23
- 239000010935 stainless steel Substances 0.000 claims abstract description 23
- 238000000498 ball milling Methods 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 238000002513 implantation Methods 0.000 claims description 29
- 230000008018 melting Effects 0.000 claims description 28
- 238000002844 melting Methods 0.000 claims description 28
- 238000002360 preparation method Methods 0.000 claims description 21
- 235000012241 calcium silicate Nutrition 0.000 claims description 20
- 239000000758 substrate Substances 0.000 claims description 18
- 238000000465 moulding Methods 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 7
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 238000005422 blasting Methods 0.000 claims description 6
- 239000000155 melt Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 abstract description 16
- 239000000378 calcium silicate Substances 0.000 abstract description 2
- 229910052918 calcium silicate Inorganic materials 0.000 abstract description 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 20
- 210000000988 bone and bone Anatomy 0.000 description 11
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000032798 delamination Effects 0.000 description 7
- 229910000831 Steel Inorganic materials 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 239000010959 steel Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 239000004567 concrete Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 230000010287 polarization Effects 0.000 description 5
- 229910052786 argon Inorganic materials 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000007797 corrosion Effects 0.000 description 4
- 238000005260 corrosion Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000003462 bioceramic Substances 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- IXSZQYVWNJNRAL-UHFFFAOYSA-N etoxazole Chemical compound CCOC1=CC(C(C)(C)C)=CC=C1C1N=C(C=2C(=CC=CC=2F)F)OC1 IXSZQYVWNJNRAL-UHFFFAOYSA-N 0.000 description 2
- 210000001981 hip bone Anatomy 0.000 description 2
- 229910052750 molybdenum Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 206010068975 Bone atrophy Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000006004 Quartz sand Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 229910008947 W—Co Inorganic materials 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 229910000963 austenitic stainless steel Inorganic materials 0.000 description 1
- 239000011173 biocomposite Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 210000003109 clavicle Anatomy 0.000 description 1
- 238000011960 computer-aided design Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000013499 data model Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000006101 laboratory sample Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000000537 nasal bone Anatomy 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000001582 osteoblastic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000012890 simulated body fluid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000000216 zygoma Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/20—Direct sintering or melting
- B22F10/28—Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/30—Process control
- B22F10/36—Process control of energy beam parameters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/30—Process control
- B22F10/36—Process control of energy beam parameters
- B22F10/366—Scanning parameters, e.g. hatch distance or scanning strategy
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/60—Treatment of workpieces or articles after build-up
- B22F10/66—Treatment of workpieces or articles after build-up by mechanical means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
- B22F3/10—Sintering only
- B22F3/105—Sintering only by using electric current other than for infrared radiant energy, laser radiation or plasma ; by ultrasonic bonding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/30—Process control
- B22F10/32—Process control of the atmosphere, e.g. composition or pressure in a building chamber
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/30—Process control
- B22F10/36—Process control of energy beam parameters
- B22F10/362—Process control of energy beam parameters for preheating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F2998/00—Supplementary information concerning processes or compositions relating to powder metallurgy
- B22F2998/10—Processes characterised by the sequence of their steps
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/25—Process efficiency
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Automation & Control Theory (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Plasma & Fusion (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Mechanical Engineering (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a composite material. The composite material is prepared from, by volume, 85-95% of stainless steel powder and 5-15% of calcium silicate powder. The invention further provides application of the composite material as a biomedical composite implant material and a preparing method thereof. According to the preparing method of the biomedical composite implant material, after the components are mixed, the stirring and ball milling technology is adopted for preparing composite powder; after a human body implant three-dimensional model is constructed, the slicing technology is adopted for calculating the two-dimensional cross section, the composite powder is laid, scanned through laser beams and melted to form one two-dimensional cross section of an implant, and the steps are repeated, so that the implant body three-dimensional model is formed and subjected to after-treatment to obtain the biomedical composite implant material. According to the biomedical composite implant material and the preparing method thereof, mechanical properties and biocompatibility of the material can be controlled effectively, and various requirements of the human body for the implant material can be met.
Description
Technical field
The invention belongs to biology medical material technical field, relate to a kind of bio-medical composite implantation material and preparation method thereof, tool
Body relates to a kind of employing stirring ball-milling and selective laser melting technology quickly prepares bio-medical 316L rustless steel with calcium silicates again
Close embedded material and method thereof.
Background technology
Selective laser melting technology is that a kind of new pattern laser increases material manufacturing technology, and principle based on layering superposition is swashed by high energy
Light beam is completely melt metal dust, thus the 3 D auto realizing part shapes.This technology is a rapid melting and the mistake of solidification
Journey, formation of parts crystal grain is tiny, high comprehensive performance, has significant advantage in terms of shaping fine labyrinth.Additionally, base
Yu Zengcai manufactures and the feature of dusty material, and selective laser melting technology also has the advantage saving material.Based on above advantage,
This technology has been applied to multiple fields such as Aero-Space, biological manufacture and military project.Especially at biological manufacture view, this technology because of
Its high accuracy, high customization and can shape the feature of complex internal structure, be extremely suitable for the manufacture of human bearing's body.
Bio-medical material refers to for organism diagnoses, treats, repairs or replaces disease damage tissue, organ, or promotes
The material of its function.In hard tissue repair and replacement field, whole world biomaterial industry amount of production is annual the most quickly to be increased.
According to estimates, 300,000 example joint replacement surgery will be carried out every year in the U.S.；The whole world accepts hipbone operation every year then has 500,000 people left
The right side, and this numeral is also increasing with the speed of 100,000 person/year.But only in Britain, the hipbone carried out every year replaces in operation
Just having 18% is to reprocess operation；In China, the most also there is millions of example Cranial defect patient, but in the clinical practice of biologic implant
On, also it is limited only to Maxillary region (such as nasal bone, clavicle, cheekbone etc.), for carrying, position sclerous tissues (such as joint bone, is also the easiest
Impaired position), the most also rarely have real successfully application.Therefore, the artificial hard tissue repair that structure is the most lasting and replacement biology
Material has great practical significance, actively develops correlational study work imperative.
Rustless steel is to apply a class biomaterial the earliest, the most history of over half a century.At medical stainless steel material
In, austenitic stainless steel is because of its good mechanical performance, corrosion resistance and cheap price, and is widely applied.Medical
There is following subject matter in rustless steel: (1) case hardness is relatively low, and wearability is poor, sensitive to spot corrosion in the fluid environment of human body,
And corrosion will pass through the cell reaction to electric current, the pH value of change tissue also discharges Ni, Cr, Mo etc. to human body
Harmful metal ion, causes local organization allergy pain, even induces canceration；(2) elastic modelling quantity differs relatively big with people's osseous tissue,
It is easily generated stress shielding, makes prosthetic loosening, produce bone resorption and atrophy phenomenon, ultimately cause implantation and lost efficacy；(3) bio-compatible
Property poor, surface inactive, implant and form combination of shape and state after human body environment with body system, impact is implanted effect and is caused and plants
Enter failure.
Hydroxyapatite, calcium phosphate, calcium silicates and the similar pottery close with natural bone composition becomes the ideal of skeleton implant
Material.Research shows, calcium silicate powder or pottery have good biological activity and induction and deposition class bone hydroxyapatite in vitro
The ability of layer, the formation of hydroxyapatite layer may advantageously facilitate bone conduction and the osteanagenesis of material, and promotes to be formed with soft/sclerous tissues
Chemical bonding effect.But bioceramic mechanical property is poor, the application in load-bearing bone and large scale bone tissue restoration receives
Limit.Therefore, metal material and bioceramic material are combined and prepare Biocomposite material and increasingly paid attention to by scholars,
Become current study hotspot.
Summary of the invention
The shortcoming of prior art in view of the above, it is an object of the invention to provide the system of a kind of bio-medical composite implantation material
Preparation Method, this kind of bio-medical 316L rustless steel and the preparation method of calcium silicates composite implantation material, it is possible to solve in prior art
Prepare the bottleneck of baroque implant, it is possible to more precisely control implant forming dimension, it is achieved the once one-tenth of implant
Type, and have more preferable biocompatibility than simple metal implant.
Another object of the present invention is to bio-medical 316L rustless steel and the silicon providing a kind of comprehensive mechanical property close with people's bone
Acid calcium composite implantation material, after implanting human body, is prevented effectively from stress shielding, prevents implant from loosening, improves implant material
Stability.
For achieving the above object and other relevant purposes, the present invention provides a kind of composite, by volume percentages, including with
Lower component:
Powder of stainless steel 85-95vol%；
Calcium silicates powder 5-15vol%.
Preferably, described composite, by volume percentages, including following components:
Powder of stainless steel 90vol%；
Calcium silicates powder 10vol%.
Preferably, described powder of stainless steel is 316L powder of stainless steel.
It is highly preferred that the mean diameter of described 316L powder of stainless steel is 40-60 μm.
It is further preferred that the mean diameter of described 316L powder of stainless steel is 50 μm.
Preferably, the mean diameter of described calcium silicates powder is 5-15 μm.
It is highly preferred that the mean diameter of described calcium silicates powder is 10 μm.
The present invention further provides a kind of composite purposes as bio-medical composite implantation material.
The present invention furthermore provides the preparation method of a kind of bio-medical composite implantation material, comprises the following steps:
1), after powder of stainless steel and calcium silicates powder being mixed, stirring ball-milling technique is used to prepare composite powder；
Preferably, described powder of stainless steel and calcium silicates powder, with volume percentage, addition be respectively 85-95vol% and
5-15vol%.
It is highly preferred that described powder of stainless steel and calcium silicates powder, with volume percentage, addition be respectively 90vol% and
10vol%.
Preferably, described powder of stainless steel is 316L powder of stainless steel.
It is highly preferred that the mean diameter of described 316L powder of stainless steel is 40-60 μm.
It is further preferred that the mean diameter of described 316L powder of stainless steel is 50 μm.
Preferably, the mean diameter of described calcium silicates powder is 5-15 μm.
It is highly preferred that the mean diameter of described calcium silicates powder is 10 μm.
Preferably, the ball mill that described stirring ball-milling technique uses is ground.
It is highly preferred that the mill ball used in described ball mill is sintered carbide ball, a diameter of 5 ± 0.1mm of described mill ball.
The material of described sintered carbide ball is YG6 W-Co kind hard alloy.
It is highly preferred that the ball material mass ratio of the mill ball used in described ball mill and composite powder is 9-11:1.
It is further preferred that the ball material mass ratio of described mill ball and composite powder is 10:1.
It is highly preferred that the grinding condition of described ball mill is: the rotating speed of mixing arm: 200-300 rev/min；Ball-milling Time: 10-15
Hour.
2), after building body implant's threedimensional model, use slice process to calculate two-dimensional cross sectional, and two-dimensional cross sectional information is passed
Deliver to the control unit of selective laser melting former；
Preferably, described body implant's threedimensional model uses three-dimensional drawing software to build.Three-dimensional drawing software is used to carry out
When building threedimensional model, needed for needing basis, prepare the practical structures of embedded material, design and set up actual threedimensional model, and will
Three-dimensional model information saves as STL formatted file.
It is highly preferred that a kind of engineering drawing software that described three-dimensional drawing software is in CAD, Solidworks, UG, ProE.
Preferably, described slice process is to import in delamination software by three-dimensional model information, after delamination software step section,
Calculate two-dimensional cross sectional again, and two-dimensional cross sectional information is saved as SLM formatted file.
It is highly preferred that described delamination software is Autofab software.Described Autofab software can be by three-dimensional (3D) model along certain
One direction (Z axis) discrete for a series of two dimension aspect, obtain a series of two dimensional surface information, two dimensional surface thickness is controlled
For 0.1-0.01mm.
Preferably, described selective laser melting former refers to according to selective laser melting technology (Selective Laser
Melting) former be designed, manufactured.
Preferably, the control unit of described selective laser melting former refers to the calculating of selective laser melting former
Machine control system.Those skilled in the art all understand, and the calculating process of unit controlled as described above, all can utilize prior art
In computer, integrated circuit modules, PLD, other hardware or existing software module realize.
Described selective laser melting technology (Selective Laser Melting) is advanced increasing material manufacturing technology, and it need not mould
Tool, " is piled up layer by layer " by dusty material, is completely melt the principle of every layer of powder, by computer-aided design data model,
Quickly produce the controllable precise manufacture of the three-dimensional entity model of complexity.
3) on substrate, lay one layer of composite powder, according to the two-dimensional cross sectional information being stored in described control unit, use and swash
Light beam scans corresponding transverse cross-sectional area and melts the composite powder in transverse cross-sectional area, forms two of implant
Dimension cross section；
Preferably, described substrate is to use nut to be fixed on the underboarding on the workbench of selective laser melting equipment.
It is highly preferred that the specification of described substrate is 300mm × 300mm × 20mm (length × width × height).
Preferably, described substrate needs to preheat before first paving powder.Described preheating is to adjust substrate to laser focusing to click on
OK.Described substrate plays the effect that part is fixed and dispelled the heat in the course of processing.
It is highly preferred that described preheating condition is: preheating temperature: 600-800 DEG C；Preheating time: 3-5min.
Preferably, described one layer of composite powder of laying on substrate, use power spreading device to lay.
It is highly preferred that described power spreading device is powder-laying roller.
Preferably, the thickness of described composite powder is 0.02 ± 0.01mm.
Preferably, described laser beam flying condition is: laser power: 120-180W；Sweep span: 0.07 ± 0.01mm；Sweep
Retouch speed: 350-500mm/s.
It is highly preferred that described laser beam flying condition is: laser power 140-160W；Sweep span 0.07mm；Scanning speed:
400mm/s。
Preferably, before described laser beam is scanned, need the processing adjusting in the cavity of selective laser melting former
Environment.
It is highly preferred that need to carry out evacuation in the cavity of described selective laser melting former.
It is further preferred that described evacuation uses mechanical pump to extract, vacuum is not more than-1Mpa.
It is highly preferred that be filled with high-purity argon gas as protective gas in the cavity of described selective laser melting former.Described height
Pure argon concentration in cavity is not less than 99.99vol%.
It is highly preferred that the concentration of oxygen is less than 0.01vol% in the cavity of described selective laser melting former.Avoid selecting
Property laser fusion former the oxidation of chamber in-vivo metal powder, affect the preparation of described implant material.
4) two-dimensional cross sectional of above-mentioned formation is declined the thickness height of one layer of composite powder；
Preferably, the thickness height of described one layer of composite powder of decline and the thickness height phase laying one layer of composite powder on substrate
Deng.
It is the bench height accurately being adjusted selective laser melting equipment by servomotor that described two-dimensional cross sectional declines, and makes work
The high precision of station declines, thus drives the high precision being fixed on workbench upper substrate to decline, and then makes formation on substrate
The high precision of two-dimensional cross sectional declines.
It is highly preferred that the thickness height of described one layer of composite powder of decline is 0.02 ± 0.01mm.
5) step 3 is repeated) and 4), until it reaches the final two-dimensional cross sectional of described implant threedimensional model, so that planting
Enter body three-dimensional models molding；
6) do blasting treatment after being cooled down by the threedimensional model of molding, obtain bio-medical composite implantation material.
Preferably, room temperature it is cooled to described in.Described room temperature is 20-25 DEG C.
Preferably, described blasting treatment uses compressed air to be power, to form high velocity spray beam by quartz sand high velocity jet to needing
Surface of the work to be processed, to remove the powder residual of surface of the work.Described blasting treatment is the mode of conventional treatment model.
It addition, the present invention further provides a kind of bio-medical composite implantation material, above-mentioned preparation method prepare.
As it has been described above, the invention provides a kind of bio-medical composite implantation material and preparation method thereof, prepare a kind of biological
Medical 316L stainless steel and calcium silicates composite implantation material, its implant material body uses selective laser melting composite powder trifling skill
Art is made, and described composite powder uses stirring ball-milling 316L powder of stainless steel and calcium silicates powder to be prepared from.
Compared with prior art, a kind of bio-medical 316L rustless steel and the calcium silicates composite implantation material preparation side that the present invention provides
Method, integration system is for biomedical implant material, it is not necessary to subsequent treatment, and flow process is simple.This kind of preparation method, solves existing
There is in technology the bottleneck preparing baroque implant, it is possible to more precisely control implant forming dimension, it is achieved to material
Mechanical property control effectively.Meanwhile, composite implantation material performance prepared by this kind of preparation method is close with people's bone, implants
After human body, it is prevented effectively from stress shielding, prevents implant from loosening, improve the stability of implant material, and implant than simple metal
Body has more preferable biocompatibility, and its biocompatibility is conducive to osteoblastic growth, meets each to implant material of human body
The demand of kind.
Accompanying drawing explanation
Fig. 1 be shown as scanning speed be 400mm/s, laser power composite sample stress-strain diagram when being 120-180W
Figure.
Fig. 2 be shown as scanning speed be 350-500mm/s, laser power composite sample stress-strain diagram when being 140W
Figure.
Fig. 3 is shown as composite sample polarization curve under different laser scanning speed 350-500mm/s.
Fig. 4 is shown as composite sample polarization curve under different laser power 120-180W.
Detailed description of the invention
The present invention is expanded on further, it should be appreciated that these embodiments are merely to illustrate the present invention and need not below in conjunction with specific embodiment
In limiting the scope of the invention.
Below by way of specific instantiation, embodiments of the present invention being described, those skilled in the art can be by disclosed by this specification
Content understand other advantages and effect of the present invention easily.The present invention can also be added by the most different detailed description of the invention
To implement or application, the every details in this specification can also be based on different viewpoints and application, in the essence without departing from the present invention
Various modification or change is carried out under god.
It should be clear that the conventional equipment in the not concrete process equipment indicated or device all use this area in the following example or device；
All force value and scope are all referring to relative pressure.
In addition, it is to be understood that the one or more method steps mentioned in the present invention do not repel before and after described combination step all right
There is additive method step or additive method step can also be inserted, except as otherwise noted between these steps specifically mentioned；
Should also be understood that the combination annexation between the one or more equipment/devices mentioned in the present invention is not repelled to set in described combination
Other equipment/devices can also be there are before and after standby/device or can also be inserted it between these two equipment/devices specifically mentioned
His equipment/device, except as otherwise noted.And, except as otherwise noted, the numbering of various method steps only differentiates various method steps
Convenient tool, rather than for limit various method steps ordering or limit the enforceable scope of the present invention, its relativeness
It is altered or modified, in the case of without essence change technology contents, when being also considered as the enforceable category of the present invention.
The equipment used in following example is as follows:
AXT-S series vertical lifting agitating ball mill (Jiangsu Ming Hai machinery)；HRPM-II type SLM system selective laser melts
Change former (Central China University of Science and Technology develops jointly) with Shanghai Spaceflight Equipment Manufacture Head Factory.
Embodiment 1
A kind of bio-medical composite implantation material of preparation, comprises the following steps:
(1) 90vol%316L powder of stainless steel and the 10vol% calcium silicates of mean diameter 10 μm of particle diameter 50 μm it are averaged
Powder mixes, and uses ball mill to be ground, and the mill ball used in ball mill is sintered carbide ball, the diameter of described mill ball
For 5mm, the diameter deviation≤0.1mm of mill ball.The mill ball used in described ball mill with the ratio of grinding media to material of composite powder is
10:1.The rotating speed of mixing arm is 200 revs/min, and Ball-milling Time is 10h.
(2) use CAD software to build body implant's threedimensional model, and three-dimensional model information is saved as STL formatted file.
STL formatted file is imported in Autofab delamination software, after delamination software step section, then calculates two-dimensional cross sectional,
And two-dimensional cross sectional information is saved as SLM formatted file.Autofab software can be discrete for a series of along Z axis by threedimensional model
Two-dimentional aspect, obtain a series of two dimensional surface information, two dimensional surface thickness is controllable to 0.1-0.01mm.Again by SLM lattice
Formula file is sent in the computer control system of selective laser melting former.
(3) composite powder of one layer of 0.02mm of laying on powder-laying roller substrate on the workbench of selective laser melting equipment is used
End, wherein, the size of substrate is 300mm × 300mm × 20mm, and substrate uses nut to fix, and needs before first paving powder
Adjusting and preheat to laser focusing point, preheating temperature is 700 DEG C, and preheating time is 4min.
(4) then, according to the two-dimensional cross sectional information being stored in computer control system, use laser beam flying corresponding
Transverse cross-sectional area also melts the composite powder in transverse cross-sectional area, forms a two-dimensional cross sectional of implant.Laser beam flying bar
Part is: laser power: 120-180W；Sweep span: 0.07mm；Scanning speed: 350-500mm/s.By above-mentioned formation
Two-dimensional cross sectional declines the thickness height of the composite powder of one layer of 0.02mm.
(5) step (3) and (4) is repeated, until it reaches the final two-dimensional cross sectional of described implant threedimensional model, thus
Make implant threedimensional model molding.Do blasting treatment after the threedimensional model of molding is cooled to room temperature, obtain that bio-medical is compound plants
Enter material sample 1#.
Before the laser beam of selective laser melting equipment is scanned, need to adjust the chamber of selective laser melting former
Internal processing environment.Use mechanical pump that working chamber is evacuated to-1Mpa, and be slowly introducing high-purity argon gas as protection
Gas, and make the concentration of oxygen in working chamber less than 0.01%, to avoid metal powder to aoxidize, affect the system of described implant material
Standby.
Embodiment 2
A kind of bio-medical composite implantation material of preparation, comprises the following steps:
(1) 85-95vol%316L powder of stainless steel and the 5-15vol% of mean diameter 5-15 μm of particle diameter 40-60 μm it are averaged
Calcium silicates powder mixes, and uses ball mill to be ground, and the mill ball used in ball mill is sintered carbide ball, described mill ball
A diameter of 5mm, the diameter deviation≤0.1mm of mill ball.The mill ball used in described ball mill and the ball material of composite powder
Ratio is 9-11:1.The rotating speed of mixing arm is 300 revs/min, and Ball-milling Time is 15h.
(2) use Solidworks software building body implant's threedimensional model, and three-dimensional model information is saved as STL lattice
Formula file.STL formatted file is imported in Autofab delamination software, after delamination software step section, then calculates two dimension
Cross section, and two-dimensional cross sectional information is saved as SLM formatted file.Autofab software can be discrete along Z axis by threedimensional model
For a series of two dimension aspect, obtaining a series of two dimensional surface information, two dimensional surface thickness is controllable to 0.1-0.01mm.Again
SLM formatted file is sent in the computer control system of selective laser melting former.
(3) use and lay one layer of 0.02 ± 0.01mm's on powder-laying roller substrate on the workbench of selective laser melting equipment
Composite powder, wherein, the size of substrate is 300mm × 300mm × 20mm, and substrate uses nut to fix, and spreads powder for the first time
Front needs adjust and preheat to laser focusing point, and preheating temperature is 600-800 DEG C, and preheating time is 3-5min.
(4) then, according to the two-dimensional cross sectional information being stored in computer control system, use laser beam flying corresponding
Transverse cross-sectional area also melts the composite powder in transverse cross-sectional area, forms a two-dimensional cross sectional of implant.Laser beam flying bar
Part is: laser power: 120-180W；Sweep span: 0.07 ± 0.01mm；Scanning speed: 350-500mm/s.By above-mentioned
The two-dimensional cross sectional formed declines the thickness height of the composite powder of one layer of 0.02 ± 0.01mm.
(5) step (3) and (4) is repeated, until it reaches the final two-dimensional cross sectional of described implant threedimensional model, thus
Make implant threedimensional model molding.Do blasting treatment after the threedimensional model of molding is cooled to room temperature, obtain that bio-medical is compound plants
Enter material sample 2#.
Before the laser beam of selective laser melting equipment is scanned, need to adjust the chamber of selective laser melting former
Internal processing environment.Use mechanical pump that working chamber is evacuated to-1Mpa, and be slowly introducing high-purity argon gas as protection
Gas, and make the concentration of oxygen in working chamber less than 0.01%, to avoid metal powder to aoxidize, affect the system of described implant material
Standby.
Embodiment 3
By the bio-medical composite implantation material sample 1# of preparation in embodiment 1, measuring its density by electron density instrument is
6.25-6.89g/cm3, with skeleton density closest to.
Measuring its elastic modelling quantity by Hall element method young's elastic modulus tester again, concrete outcome is shown in Table 1.Can by table 1
Knowing, selecting laser scanning speed between 350-500mm/s, measuring the elastic modelling quantity meansigma methods obtained is 160.4-181.2GPa,
With people's flexible bone modulus closest to, result shows that it meets implant material requirement.
Sample elastic modulus (Gpa) under the different laser scanning speed of table 1.
Under conditions of employing scanning speed is 400mm/s, laser power is respectively 120W, 140W, 160W, 180W, right
Bio-medical composite implantation material sample 1# carries out laser beam flying, it is thus achieved that corresponding composite sample stress-strain diagram, specifically
Result is shown in Fig. 1.Meanwhile, scanning speed is used to be respectively 350mm/s, 400mm/s, 450mm/s, 500mm/s, laser merit
Under conditions of rate is 140W, bio-medical composite implantation material sample 1# is carried out laser beam flying, it is thus achieved that corresponding composite
Sample stress-strain diagram, concrete outcome is shown in Fig. 2.According to the composite sample stress-strain diagram in Fig. 1-2, explanation is passed through
Adjusting process parameter, can prepare the sample of different mechanical properties, and in this experimentation, it is thus achieved that meet human bearing
The laboratory sample that bone requires.
Under conditions of using scanning speed to be respectively 350mm/s, 400mm/s, 450mm/s, 500mm/s, to bio-medical
Composite implantation material sample 1# carries out laser beam flying, it is thus achieved that corresponding composite sample polarization curve, concrete outcome is shown in Fig. 3.
Meanwhile, under conditions of using laser power to be respectively 120W, 140W, 160W, 180W, implant material to bio-medical is compound
Material sample 1# carries out laser beam flying, it is thus achieved that corresponding composite sample polarization curve, concrete outcome is shown in Fig. 4.According to Fig. 3-4
In composite sample polarization curve, show this sample have in simulated body fluid excellence decay resistance, implant people
Can effectively reduce implant corrosion probability after body, reduce poisonous plasma diffusing W,Mo probability, extend implant service life, improve
Biocompatibility.
So, the present invention effectively overcomes various shortcoming of the prior art and has high industrial utilization.
The principle of above-described embodiment only illustrative present invention and effect thereof, not for limiting the present invention.Any it is familiar with this skill
Above-described embodiment all can be modified under the spirit and the scope of the present invention or change by the personage of art.Therefore, such as
All that in art, tool usually intellectual is completed under without departing from disclosed spirit and technological thought etc.
Effect is modified or changes, and must be contained by the claim of the present invention.
Claims (10)
1. a composite, by volume percentages, including following components:
Powder of stainless steel 85-95vol%；
Calcium silicates powder 5-15vol%.
Composite the most according to claim 1, it is characterised in that described powder of stainless steel is 316L powder of stainless steel.
3. according to the arbitrary described composite of claim 1-2, as the purposes of bio-medical composite implantation material.
4. a preparation method for bio-medical composite implantation material, comprises the following steps:
1), after powder of stainless steel and calcium silicates powder being mixed, stirring ball-milling technique is used to prepare composite powder；
2), after building body implant's threedimensional model, use slice process to calculate two-dimensional cross sectional, and two-dimensional cross sectional information is passed
Deliver to the control unit of selective laser melting former；
3) on substrate, lay one layer of composite powder, according to the two-dimensional cross sectional information being stored in described control unit, use and swash
Light beam scans corresponding transverse cross-sectional area and melts the composite powder in transverse cross-sectional area, forms two of implant
Dimension cross section；
4) two-dimensional cross sectional of above-mentioned formation is declined the thickness height of one layer of composite powder；
5) step 3 is repeated) and 4), until it reaches the final two-dimensional cross sectional of described implant threedimensional model, so that implanting
Body three-dimensional models molding；
6) do blasting treatment after being cooled down by the threedimensional model of molding, obtain bio-medical composite implantation material.
The preparation method of bio-medical composite implantation material the most according to claim 4, it is characterised in that step 1) in, institute
The ball mill stating the employing of stirring ball-milling technique is ground.
The preparation method of bio-medical composite implantation material the most according to claim 5, it is characterised in that described ball mill includes
Any one of following condition or multinomial:
A1) mill ball used in described ball mill is sintered carbide ball；
A2) mill ball used in described ball mill is 9-11:1 with the ball material mass ratio of composite powder；
A3) grinding condition of described ball mill is: the rotating speed of mixing arm: 200-300 rev/min；Ball-milling Time: 10-15 hour.
The preparation method of bio-medical composite implantation material the most according to claim 4, it is characterised in that step 2) in, institute
Stating body implant's threedimensional model uses three-dimensional drawing software to build.
The preparation method of bio-medical composite implantation material the most according to claim 4, it is characterised in that step 3) in, institute
Stating laser beam flying condition is: laser power: 120-180W；Sweep span: 0.06-0.08mm；Scanning speed:
350-500mm/s。
The preparation method of bio-medical composite implantation material the most according to claim 4, it is characterised in that step 4) in, institute
State the thickness height declining one layer of composite powder equal with the thickness height laying one layer of composite powder on substrate.
10. a bio-medical composite implantation material, is prepared by the preparation method as described in claim 4-9 is arbitrary.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610141352.8A CN105797206B (en) | 2016-03-11 | 2016-03-11 | A kind of bio-medical composite implantation material and preparation method thereof |
| PCT/CN2016/086964 WO2017152541A1 (en) | 2016-03-11 | 2016-06-24 | Composite biomedical implant material and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610141352.8A CN105797206B (en) | 2016-03-11 | 2016-03-11 | A kind of bio-medical composite implantation material and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105797206A true CN105797206A (en) | 2016-07-27 |
| CN105797206B CN105797206B (en) | 2019-04-09 |
Family
ID=56467372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610141352.8A Active CN105797206B (en) | 2016-03-11 | 2016-03-11 | A kind of bio-medical composite implantation material and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN105797206B (en) |
| WO (1) | WO2017152541A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110791681A (en) * | 2019-10-29 | 2020-02-14 | 华中科技大学 | Bioactive Ti-Ta-Nb alloy bone implant and forming method thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113171209B (en) * | 2021-04-27 | 2023-10-20 | 山东大学 | Additive manufacturing nickel-titanium alloy femoral stem prosthesis and preparation method thereof |
| CN115074575A (en) * | 2022-06-13 | 2022-09-20 | 长沙学院 | High-strength high-bioactivity degradable zinc-based composite material and preparation method thereof |
| CN115673339B (en) * | 2023-01-03 | 2023-04-07 | 西安赛隆增材技术股份有限公司 | Three-dimensional manufacturing method of zirconium-niobium alloy orthopedic implant |
| CN117206544B (en) * | 2023-11-09 | 2024-02-20 | 四川工程职业技术学院 | Laser selective melting forming method for Zn-Cu-Mn-Mg alloy porous structure |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512267A (en) * | 2011-12-07 | 2012-06-27 | 上海交通大学 | Bone restoration body with composite porous structure and preparation method thereof |
| US20140314964A1 (en) * | 2013-04-18 | 2014-10-23 | Arcam Ab | Method and apparatus for additive manufacturing |
| CN104399978A (en) * | 2014-11-27 | 2015-03-11 | 华南理工大学 | 3D (Three Dimensional) forming method for large-sized porous amorphous alloy part of complex shape |
| CN104972123A (en) * | 2015-05-22 | 2015-10-14 | 上海悦瑞电子科技有限公司 | 3D printing method for molecular structure model and 3D printer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8454362B2 (en) * | 2006-10-16 | 2013-06-04 | Natural Dental Implants Ag | Customized dental prosthesis for periodontal- or osseointegration, and related systems and methods |
| CN101229587A (en) * | 2008-02-20 | 2008-07-30 | 暨南大学 | Biological ceramics titanium base compound material and manufacturing method thereof |
| CN101269238A (en) * | 2008-04-24 | 2008-09-24 | 中南大学 | 316L toughening HA group biological function gradient material and preparation method thereof |
| CN102634687A (en) * | 2012-04-18 | 2012-08-15 | 北京科技大学 | Method for preparing stainless steel biological porous implant material by selective laser sintering |
| CN105014069A (en) * | 2014-04-23 | 2015-11-04 | 中南大学 | Magnesium alloy bone scaffold with controllable degradation rate and preparation method of magnesium alloy bone scaffold |
-
2016
- 2016-03-11 CN CN201610141352.8A patent/CN105797206B/en active Active
- 2016-06-24 WO PCT/CN2016/086964 patent/WO2017152541A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512267A (en) * | 2011-12-07 | 2012-06-27 | 上海交通大学 | Bone restoration body with composite porous structure and preparation method thereof |
| US20140314964A1 (en) * | 2013-04-18 | 2014-10-23 | Arcam Ab | Method and apparatus for additive manufacturing |
| CN104399978A (en) * | 2014-11-27 | 2015-03-11 | 华南理工大学 | 3D (Three Dimensional) forming method for large-sized porous amorphous alloy part of complex shape |
| CN104972123A (en) * | 2015-05-22 | 2015-10-14 | 上海悦瑞电子科技有限公司 | 3D printing method for molecular structure model and 3D printer |
Non-Patent Citations (3)
| Title |
|---|
| 林红: "《口腔材料学 第2版 第1次印刷》", 31 December 2013, 北京：北京大学医学出版社 * |
| 毛旭艳等: "3D打印生物材料的研究进展", 《济宁医学院学报》 * |
| 胡晓熙等: "《无机材料性质及其发展研究 第1版第1次印刷》", 30 April 2015, 北京：中国水利水电出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110791681A (en) * | 2019-10-29 | 2020-02-14 | 华中科技大学 | Bioactive Ti-Ta-Nb alloy bone implant and forming method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105797206B (en) | 2019-04-09 |
| WO2017152541A1 (en) | 2017-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bai et al. | Additive manufacturing of customized metallic orthopedic implants: Materials, structures, and surface modifications | |
| CN105797206A (en) | Biomedical composite implant material and preparing method thereof | |
| Zhao et al. | Bionic design and 3D printing of porous titanium alloy scaffolds for bone tissue repair | |
| Dall’Ava et al. | 3D printed acetabular cups for total hip arthroplasty: a review article | |
| Ho et al. | A review on 3D printed bioimplants | |
| Buj-Corral et al. | Development of am technologies for metals in the sector of medical implants | |
| Hao et al. | Biomedical titanium alloys and their additive manufacturing | |
| Guo et al. | Biomedical applications of the powder‐based 3D printed titanium alloys: a review | |
| CN103328016B (en) | Implant for in-vivo insertion which is formed with a porous coating layer thereon | |
| CN106312060B (en) | A kind of preparation method of the low modulus medical titanium alloy 3-dimensional metal part of high-performance | |
| CN104784760B (en) | Low-elastic-modulus integrated titanium-based femoral handle and preparation method thereof | |
| Song et al. | The design and manufacturing of a titanium alloy beak for Grus japonensis using additive manufacturing | |
| CN104646669A (en) | Biomedical porous pure-titanium implant material and preparation method thereof | |
| Syam et al. | Rapid prototyping and rapid manufacturing in medicine and dentistry: This paper presents an overview of recent developments in the field of rapid prototyping and rapid manufacturing with special emphasis in medicine and dentistry | |
| Vaiani et al. | Ceramic materials for biomedical applications: an overview on properties and fabrication processes | |
| CN108971500B (en) | High-corrosion-resistance in-situ nano carbide reinforced stainless steel implant and forming method thereof | |
| Koptyug et al. | Additive manufacturing technology applications targeting practical surgery | |
| CN106421892A (en) | Titanium-based tantalum coating bio-scaffold material and preparation method thereof | |
| Du et al. | A systematic approach for making 3D-printed patient-specific implants for craniomaxillofacial reconstruction | |
| Pesode et al. | Additive manufacturing of metallic biomaterials and its biocompatibility | |
| Banerjee et al. | Emerging technologies in arthroplasty: additive manufacturing | |
| CN105256160B (en) | A kind of 3D printing method of ceramic base nickel alloy composite | |
| CN109620475A (en) | One kind being implanted into preparation based on CT data individuation porous titanium alloy shin bone | |
| Dobrzański et al. | Computer aided design in Selective Laser Sintering (SLS)–application in medicine | |
| Sing | Selective laser melting of novel titanium-tantalum alloy as orthopaedic biomaterial |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zong Jin Inventor after: Guan Xianxian Inventor after: Zhou Bingbing Inventor after: Wang Liang Inventor before: Chen Yuechang Inventor before: Zheng Zeng Inventor before: Zhu Jun Inventor before: Han Lisong Inventor before: Wang Shixue |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20170515 Address after: 201406 room 2, building 1800, Lane 1376, Xinyang Road, Shanghai, Fengxian District Applicant after: Shanghai Kun Yao Electromechanical Technology Co. Ltd. Address before: 201406 Shanghai City, Guang Qian Road, No. 558, room 7, building 107 Applicant before: SHANGHAI TUOBAO ELECTROMECHANICAL TECHNOLOGY CO., LTD. |
|
| TA01 | Transfer of patent application right | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zong Jin Inventor after: Zhou Bingbing Inventor after: Wang Liang Inventor before: Zong Jin Inventor before: Guan Xianxian Inventor before: Zhou Bingbing Inventor before: Wang Liang |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170901 Address after: 241200 Anhui city of Wuhu province Fanchang County Economic Development Zone Applicant after: Anhui top technology Co., Ltd. Address before: 201406 room 2, building 1800, Lane 1376, Xinyang Road, Shanghai, Fengxian District Applicant before: Shanghai Kun Yao Electromechanical Technology Co. Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |