CN105014069A - Magnesium alloy bone scaffold with controllable degradation rate and preparation method of magnesium alloy bone scaffold - Google Patents
Magnesium alloy bone scaffold with controllable degradation rate and preparation method of magnesium alloy bone scaffold Download PDFInfo
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Abstract
Magnesium metal has good biocompatibility and degradability, high specific strength and specific stiffness, and can effectively reduce the stress shielding effect; but the degradation rate is too fast, the excessively-high local PH value can be caused by degradation products, and accordingly inflammation and even cell hemolysis can be caused very easily. Hydroxyapatite becomes a preferred material in active ceramic because of the excellent biocompatibility and bioactivity of the hydroxyapatite; but because of high brittleness and a lower degradation rate, the hydroxyapatite is not suitable for being directly used for load-bearing parts in vitro. The invention provides a magnesium alloy bone scaffold with the controllable degradation rate and a preparation method of the magnesium alloy bone scaffold. Specifically, the hydroxyapatite low in degradation speed and good in bioactivity is composited into magnesium metal so that magnesium alloy can be formed; fast solidification of sintered pieces is achieved through fast heating and cooling of lasers so that the degradation rate of metal magnesium can be decreased; and the degradation rate is controllable by controlling the adding amount.
Description
Technical field
The present invention relates to controlled magnesium alloy bone support of a kind of degradation rate and preparation method thereof, belong to biological manufacture field.
Background technology
Metal material, because having the combination properties such as higher mechanical strength, elasticity and plasticity, plays key player in the biomaterial of repairing bone defect.But current most widely used metal material is as stainless steel, titanium alloy and cobalt alloy etc., easily cause the complication such as the release of stress-shielding effect, toxic metal ions and chronic inflammation, the more important thing is that these metal materials can not be degraded in vivo voluntarily, second operation taking-up need be carried out, not only increase surgery cost, and can cause patient and again injure.
Magnesium metal has good biocompatibility and degradability, has higher specific strength and specific stiffness, and its elastic modelling quantity is also close with people's bone, effectively can reduce stress-shielding effect.But only there is short period (2-3 month) disappearance of will degrading (body implanting material needs the military service phase of at least 3 months usually) in vivo in magnesium, the requirement of bone uptake can not be met, and the too fast liberation of hydrogen that also can cause of degradation rate is accelerated, in addition, catabolite also can cause local ph too high, brings out the inflammation even clinical symptoms such as cell haemolysis.These problems seriously hinder magnesium metal as the application of bone implant material on clinical medicine.
Hydroxyapatite (HAP) with its superior biocompatibility and biologically active by people are paid close attention to.Its chemical composition, crystal structure are very similar to the hydroxyapatite of formation tissue, directly chemical bond can be formed with bone tissue after implanting, and bone tissue can be induced to grow into, oneself becomes the preferred material in active ceramic, but due to higher fragility, lower intensity and the slower degradation rate of hydroxyapatite, make it and be not suitable for the weight bearing area that is directly used in organism.
We know on the other hand, and fast solidification technology can improve composition and the structural homogenity of magnesium alloy, reduce defect, suppress local corrosion; Fast solidification technology also can improve the inertia of Second Phase Particles in magnesium alloy simultaneously, thus alleviates the corrosion tendency of magnesium alloy.What is more important, because fast solidification technology can increase the same solubility of vitreum oxide-film element, promotes to have more protectiveness and the formation having the hyaloid membrane of " self-healing " ability, therefore can improve the decay resistance of magnesium alloy materials.
Therefore, this patent proposes magnesium metal by composite hydroxylapatite composition and utilize fast solidification technology to delay the method for material corrosion speed.To the requirement that magnesium alloy bracket can be made to reach clinical Bone Defect Repari.
Summary of the invention
The object of this invention is to provide controlled magnesium alloy bone support of a kind of degradation rate and preparation method thereof, specifically utilize hydroxyapatite degradation speed is slow and biologically active is good feature to be compound in magnesium metal and form magnesium alloy, and the rapid solidification of sintered part is realized by the feature of laser rapid heating and cooling, to the degradation rate of magnesium metal can be delayed, and by controlling the amount of adding, realize the controlled of degraded.
The preparation method of the magnesium alloy bone support that degradation rate is controlled in the present invention, key step is as follows:
(1) weigh a certain amount of magnesium metal dust and hydroxylapatite ceramic powder respectively, put into the ball mill being connected with argon gas simultaneously, ball milling 3 hours, obtain the composite powder that magnesium metal dust mixes with hydroxylapatite ceramic powder;
(2) preset paving powder craft is adopted, on the laser sintering system developed voluntarily, according to designed structural requirement, at laser power 80 ~ 100W, sweep speed 100 ~ 200mm/min, sweep span 1mm, under spot diameter 0.5mm, argon atmospheric pressure 5MPa, laser is utilized to scan composite powder selectively;
(3) composite powder realizes sintering under the effect of laser, after having sintered one deck, takes out sintered part and re-starts auxiliary powder and sintering, constantly repeat this technique until terminate.Take out after sintered part removes the powder of end sintering and finally obtain magnesium alloy bone support.
Compared with prior art, feature of the present invention is as follows:
(1) biocompatibility utilizing hydroxyapatite good and biologically active, make magnesium alloy bone support have excellent biology performance, and can slow down the degradation rate of magnesium metal.
(2) in conjunction with the ultrafast heating of laser and the feature of cooling, the rapid solidification of magnesium alloy can be realized, composition and the structural homogenity of magnesium alloy can be improved, delay the degradation speed of magnesium alloy further.
(3) magnesium metal has been polymerized the advantage of the two after hydroxyapatite compound, not only increases biological property, and has and be suitable as the tough and tensile metal strength of bone support and hardness.
(4) it is simple that preparation method involved in the present invention has technological process, the advantages such as sintering time is short, working (machining) efficiency is high, safety non-pollution.
Detailed description of the invention
Magnesium alloy bone support that the degradation rate further illustrated in the present invention below in conjunction with example is controlled and preparation method thereof:
Embodiment one:
Weigh 100 grams of magnesium dust (purity > 99.9%, diameter < 30um) and 1 gram of hydroxylapatite ceramic powder (purity > 99%, wide 20nm, long 150nm), put into the ball mill being connected with argon gas, ball milling 3 hours, obtains the composite powder that magnesium dust mixes with hydroxyapatite powder;
(2) preset paving powder craft is adopted to complete composite powder, be seated on sintering platform, according to pre-designed structural requirement, at laser power 90W, sweep speed 150mm/min, sweep span 1mm, under spot diameter 0.5mm, argon atmospheric pressure 5MPa, laser is utilized to scan composite powder selectively;
(3) composite powder realizes sintering under the effect of laser, after having sintered one deck, takes out sintered part and re-starts auxiliary powder and sintering, constantly repeat this technique until terminate.Take out after sintered part utilizes gases at high pressure and hairbrush to remove the powder of end sintering and finally obtain magnesium alloy bone support.
Bone support prepared by said method has the interconnecting pore structure of about 500um size.
Embodiment two: use the technological parameter identical with embodiment one, only changing composite powder proportioning is 100 grams of magnesium dusts and 2 grams of hydroxyapatite powders.
Embodiment three: use the technological parameter identical with embodiment one, only changing composite powder proportioning is 100 grams of magnesium dusts and 0.5 gram of hydroxyapatite powder.
Claims (4)
1. the magnesium alloy bone support that degradation rate is controlled and a preparation method, key step comprises:
(1) weigh a certain amount of magnesium metal dust and hydroxylapatite ceramic powder respectively, put into the ball mill being connected with argon gas simultaneously, ball milling 3 hours, obtain the composite powder that magnesium metal dust mixes with hydroxylapatite ceramic powder;
(2) preset paving powder craft is adopted, on the laser sintering system developed voluntarily, according to designed structural requirement, at laser power 80 ~ 100W, sweep speed 100 ~ 200mm/min, sweep span 1mm, under spot diameter 0.5mm, argon atmospheric pressure 5MPa, laser is utilized to scan composite powder selectively;
(3) composite powder realizes sintering under the effect of laser, after having sintered one deck, takes out sintered part and re-starts auxiliary powder and sintering, constantly repeat this technique until terminate.Take out after sintered part removes the powder of end sintering and finally obtain magnesium alloy bone support.
2. according to the preparation method of the controlled magnesium alloy bone support of degradation rate described in claim 1, it is characterized in that: the biocompatibility utilizing hydroxyapatite good and biologically active, make magnesium alloy bone support have excellent biology performance, and the degradation rate of magnesium metal can be slowed down.
3. according to the preparation method of the controlled magnesium alloy bone support of degradation rate described in claim 1, it is characterized in that: in conjunction with the ultrafast heating of laser and the feature of cooling, the rapid solidification of magnesium alloy can be realized, improve composition and the structural homogenity of magnesium alloy, delay the degradation rate of magnesium alloy further.
4. according to the preparation method of the controlled magnesium alloy bone support of degradation rate described in claim 1, it is characterized in that: magnesium metal has been polymerized the two advantage after hydroxyapatite compound, not only increase biology performance, and have and be suitable as the tough and tensile metal strength of bone support and hardness.
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Cited By (9)
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WO2017152541A1 (en) * | 2016-03-11 | 2017-09-14 | 安徽拓宝增材制造科技有限公司 | Composite biomedical implant material and preparation method therefor |
CN107739939A (en) * | 2017-10-26 | 2018-02-27 | 中南大学 | A kind of Biological magnesium alloy with anti-microbial property and preparation method thereof |
CN109731134A (en) * | 2018-12-26 | 2019-05-10 | 中南大学湘雅二医院 | A kind of modified magnesium alloy bone implant material in surface and preparation method |
CN109925534A (en) * | 2019-01-11 | 2019-06-25 | 中南大学 | A kind of synchronous method for improving iron-based implantation material degradation rate and bioactivity |
CN109954168A (en) * | 2019-04-11 | 2019-07-02 | 江西理工大学 | A kind of iron of uniform fast degradation-nanometer hydroxyapatite medical material and preparation method thereof |
CN110237308A (en) * | 2019-06-06 | 2019-09-17 | 中南大学湘雅二医院 | It is a kind of for repairing the artificial bone and preparation method thereof of tumprigenicity bone defect |
GB2577881A (en) * | 2018-10-08 | 2020-04-15 | Functional Advanced Composite Tech Industries Ltd | Porous bioceramic scaffolds and preparation method thereof |
CN112500150A (en) * | 2020-10-23 | 2021-03-16 | 南京航空航天大学 | Magnesium alloy/biological ceramic porous scaffold and preparation method and application thereof |
CN113616858A (en) * | 2021-07-14 | 2021-11-09 | 西安理工大学 | Magnesium alloy bone splint doped with hydroxyapatite and capable of inhibiting tumor proliferation and preparation method |
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Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2017152541A1 (en) * | 2016-03-11 | 2017-09-14 | 安徽拓宝增材制造科技有限公司 | Composite biomedical implant material and preparation method therefor |
CN107739939A (en) * | 2017-10-26 | 2018-02-27 | 中南大学 | A kind of Biological magnesium alloy with anti-microbial property and preparation method thereof |
GB2577881A (en) * | 2018-10-08 | 2020-04-15 | Functional Advanced Composite Tech Industries Ltd | Porous bioceramic scaffolds and preparation method thereof |
CN109731134A (en) * | 2018-12-26 | 2019-05-10 | 中南大学湘雅二医院 | A kind of modified magnesium alloy bone implant material in surface and preparation method |
CN109925534A (en) * | 2019-01-11 | 2019-06-25 | 中南大学 | A kind of synchronous method for improving iron-based implantation material degradation rate and bioactivity |
CN109925534B (en) * | 2019-01-11 | 2020-07-07 | 中南大学 | Method for synchronously improving degradation rate and bioactivity of iron-based implant |
CN109954168A (en) * | 2019-04-11 | 2019-07-02 | 江西理工大学 | A kind of iron of uniform fast degradation-nanometer hydroxyapatite medical material and preparation method thereof |
CN109954168B (en) * | 2019-04-11 | 2021-08-27 | 江西理工大学 | Uniformly and rapidly degradable iron-nano hydroxyapatite medical material and preparation method thereof |
CN110237308A (en) * | 2019-06-06 | 2019-09-17 | 中南大学湘雅二医院 | It is a kind of for repairing the artificial bone and preparation method thereof of tumprigenicity bone defect |
CN112500150A (en) * | 2020-10-23 | 2021-03-16 | 南京航空航天大学 | Magnesium alloy/biological ceramic porous scaffold and preparation method and application thereof |
CN113616858A (en) * | 2021-07-14 | 2021-11-09 | 西安理工大学 | Magnesium alloy bone splint doped with hydroxyapatite and capable of inhibiting tumor proliferation and preparation method |
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Application publication date: 20151104 |