CN105796657A - Nasal drop for treating rhinitis and preparation method thereof - Google Patents
Nasal drop for treating rhinitis and preparation method thereof Download PDFInfo
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- CN105796657A CN105796657A CN201410840534.5A CN201410840534A CN105796657A CN 105796657 A CN105796657 A CN 105796657A CN 201410840534 A CN201410840534 A CN 201410840534A CN 105796657 A CN105796657 A CN 105796657A
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Abstract
The invention provides a nasal drop for treating rhinitis and a preparation method thereof. The nasal drop comprises, by weight, 13 to 15 parts of mint, 3 to 5 parts of Lepisorus scolopendrius, 3 to 5 parts of Corydalis temullfolia, 2 to 3 parts of Caesalpinia minax, 2 to 3 parts of licorice root and 5 ml of polysorbate-80. According to the invention, traditional Chinese medicines are reasonably combined together and exert synergistic effect; and results of repeated tests show that the nasal drop has the beneficial effects of expanding blood vessels in nasal mucosa, mitigating swelling of a nasal cavity and recovering the functions of nasal mucosa.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, particularly relate to a kind of nasal drop treating rhinitis and preparation method thereof.
Background technology
Rhinitis and nasal cavity inflammatory diseases, be the inflammation of the bronchia mucosal that virus, antibacterial, allergen, various physical and chemical factor and some systemic disease cause.Main clinical manifestation is nasal obstruction, many tears, sense of taste decline, headache and dizzy, hypomnesis etc., and can cause such as the complication such as otitis media, pharyngitis.Especially atrophic rhinitis is a kind of chronic cacorhinia being feature with nasal mucosa degeneration atrophy.When being in a bad way, patient can have the atrophy of concha nasalis periosteum and sclerotin, makes nasal cavity become roomy, and nasal secretion reduces.The nasal cavity of this patient easily has yellowish green dry crusts.If having the antibacterials such as abel's bacillus at nasal cavity growth and breeding, one foul smell will be produced, and become " ozena ".
At present, treatment rhinitis is mainly exceptionally used and orally taken for curing two kinds, and medicine for external use is generally spray or nasal drop, medicine for external use is short for its action time, it is impossible to maintains long curative effect, easily recurs after drug withdrawal, oral medicine is generally antianaphylactic Western medicine or Chinese patent medicine, but general unsatisfactory curative effect.Therefore my company develops a class expansion nasal mucosa vessels, alleviate nasal cavity swelling and the medicine of recovery nasal mucosa function.
Summary of the invention
The present invention provides a kind of nasal drop treating rhinitis and preparation method thereof, can reach expansion nasal mucosa vessels, alleviate nasal cavity swelling and recover the beneficial effect of nasal mucosa function.
Technical problem solved by the invention realizes by the following technical solutions:
A kind of nasal drop treating rhinitis, counts by weight, by Herba Menthae 13-15 part, hides Herba Lepisori Thunbergiani 3-5 part, mountain Herba rutae 3-5 part, Semen Caesalpiniae Minacis 2-3 part, Radix Glycyrrhizae 2-3 part, and Tween-80 5ml forms.
The nasal drop of above-mentioned treatment rhinitis, is obtained by following method:
(1) by Herba Menthae, hide Herba Lepisori Thunbergiani, mountain Herba rutae, Semen Caesalpiniae Minacis and Radix Glycyrrhizae cleaning after drying, be ground into coarse powder, add in 100ml distilled water with the mixing of 5mL Tween-80, extract ingredient with extraction, remove extractant, obtain the total composition of drug extract；
(2) total for drug extract composition is dissolved in 200ml distilled water, mix homogeneously, decoct 30 minutes, leach；Boil second time again and add 800ml distilled water, decoct 60 minutes, filter, concentration；
(3) concentrated solution is circulated 3 times on high pressure homogenizer, first class pressure 150Mpa, secondary pressure 50Mpa, adjust pH to 5-7, filter；
(4) filtrate after above-mentioned concentration adding the ethanol of 95%, makes alcohol content reach 60%, precipitate with ethanol overnight, filters, and filtrate recycling ethanol obtains alcohol deposit fluid, reclaims ethanol, and being concentrated into proportion is 1.01-1.03；
(5) by sterilizing 30min at above-mentioned concentrated solution 100 DEG C, whole process inflated with nitrogen is protected；
(6) subpackage, must treat the nasal drop of rhinitis.
Described Herba Menthae is perennial herb, and high 10～80cm, Herb has fragrance.Acrid in the mouth cool in nature, has the merit of dispelling wind-heat, the head, rash；Function blood circulation promoting, anti-itch detoxification and dispelling wind and heat pathogens.
Described Tibetan Herba Lepisori Thunbergiani is the herb of Plants of Polypodiaceae Lepisorus scolopendriniis (Ham. Ex Don) Mehra et Bir..Bitter in the mouth, micro-sweet, cold nature；Function heat clearing away is by wet.
Described mountain Herba rutae is herb or the root of bloodroot great Ye Herba corydalis edulis.Bitter in the mouth, pungent, cold nature；Function heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.
Described Semen Caesalpiniae Minacis is the seed of leguminous plant south Serpentis.Bitter in the mouth, cool in nature, cold；Function heat clearing away, removing dampness dissipating blood stasis.
Described Radix Glycyrrhizae is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down；Function heat-clearing and toxic substances removing, QI invigorating, lung moistening, and middle emergency, coordinating the actions of various ingredients in a prescription.
Described Tween-80 is a kind of conventional surfactant, and good hydrophilic property, is oil-in-water type, it is possible to use as emulsifying agent.
The preparation method of the nasal drop of above-mentioned treatment rhinitis, concrete preparation process is as follows:
(1) by Herba Menthae, hide Herba Lepisori Thunbergiani, mountain Herba rutae, Semen Caesalpiniae Minacis and Radix Glycyrrhizae cleaning after drying, be ground into coarse powder, add in 100ml distilled water with the mixing of 5mL Tween-80, extract ingredient with extraction, remove extractant, obtain the total composition of drug extract；
(2) total for drug extract composition is dissolved in 200ml distilled water, mix homogeneously, decoct 30 minutes, leach；Boil second time again and add 800ml distilled water, decoct 60 minutes, filter, concentration；
(3) concentrated solution is circulated 3 times on high pressure homogenizer, first class pressure 150Mpa, secondary pressure 50Mpa, adjust pH to 5-7, filter；
(4) filtrate after above-mentioned concentration adding the ethanol of 95%, makes alcohol content reach 60%, precipitate with ethanol overnight, filters, and filtrate recycling ethanol obtains alcohol deposit fluid, reclaims ethanol, and being concentrated into proportion is 1.01-1.03；
(5) by sterilizing 30min at above-mentioned concentrated solution 100 DEG C, whole process inflated with nitrogen is protected；
(6) subpackage, must treat the nasal drop of rhinitis.
Preferably, a kind of nasal drop treating rhinitis, count by weight, by Herba Menthae 14-15 part, hide Herba Lepisori Thunbergiani 4-5 part, mountain Herba rutae 4-5 part, Semen Caesalpiniae Minacis 2-3 part, Radix Glycyrrhizae 2-3 part, Tween-80 5ml forms.
Preferably, a kind of nasal drop treating rhinitis, count by weight, by Herba Menthae 15 parts, hide Herba Lepisori Thunbergiani 5 parts, mountain Herba rutae 5 parts, Semen Caesalpiniae Minacis 3 parts, 3 parts of Radix Glycyrrhizae, Tween-80 5ml forms.
The invention have the benefit that
1, the present invention adopts that pure natural draft Chinese medicine unique formula and technique are refining to be formed, reasonable formula, mutual Synergistic, and adopts Chinese crude drug comparatively common in the localities as raw material, and with low cost, medicine source is easy to get, it is possible to alleviate patient burden.
2, the present invention can be done directly on nasal membrane, make drug absorption rapid-onset, the rhinitis cellular infiltration caused by rhinitis, sinusitis can be alleviated, alleviate and eliminate nasal mucosa edema, resolution, may also suppress connective tissue proliferation under mucosa, it is thus possible to improve the caused nasal obstruction of nasal mucosa swelling, be suitable for treating multiple rhinitis.
3, the present invention is rapid-action, volume is little, easy to use, drug effect is safe and effective, without any side effects, provides more medication for patient and selects.
4, the present invention can clearing heat and moistening dryness and alleviate nasal cavity swelling, can being stained with rete, vibrissa and obstinate pathogenic bacteria carried out high concentration attack from nasal cavity.
5, preparation technology of the present invention is simple, is suitable for the needs that large-scale industrial produces.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of nasal drop treating rhinitis, counts by weight, by Herba Menthae 13 parts, hides Herba Lepisori Thunbergiani 3 parts, mountain Herba rutae 3 parts, Semen Caesalpiniae Minacis 2 parts, 2 parts of Radix Glycyrrhizae, and Tween-80 5ml forms.
The preparation method of the nasal drop of above-mentioned treatment rhinitis, concrete preparation process is as follows:
(1) by Herba Menthae, hide Herba Lepisori Thunbergiani, mountain Herba rutae, Semen Caesalpiniae Minacis and Radix Glycyrrhizae cleaning after drying, be ground into coarse powder, add in 100ml distilled water with the mixing of 5mL Tween-80, extract ingredient with extraction, remove extractant, obtain the total composition of drug extract；
(2) total for drug extract composition is dissolved in 200ml distilled water, mix homogeneously, decoct 30 minutes, leach；Boil second time again and add 800ml distilled water, decoct 40 minutes, filter, concentration；
(3) concentrated solution is circulated 3 times on high pressure homogenizer, first class pressure 100Mpa, secondary pressure 50Mpa, adjust pH to 5-7, filter；
(4) filtrate after above-mentioned concentration adding the ethanol of 95%, makes alcohol content reach 60%, precipitate with ethanol overnight, filters, and filtrate recycling ethanol obtains alcohol deposit fluid, reclaims ethanol, and being concentrated into proportion is 1.01-1.03；
(5) by sterilizing 30min at above-mentioned concentrated solution 100 DEG C, whole process inflated with nitrogen is protected；
(6) subpackage, must treat the nasal drop of rhinitis.
Embodiment 2
A kind of nasal drop treating rhinitis, counts by weight, by Herba Menthae 14 parts, hides Herba Lepisori Thunbergiani 4 parts, mountain Herba rutae 4 parts, Semen Caesalpiniae Minacis 3 parts, 3 parts of Radix Glycyrrhizae, and Tween-80 5ml forms.
The preparation method of the nasal drop of above-mentioned treatment rhinitis, concrete preparation process is as follows:
(1) by Herba Menthae, hide Herba Lepisori Thunbergiani, mountain Herba rutae, Semen Caesalpiniae Minacis and Radix Glycyrrhizae cleaning after drying, be ground into coarse powder, add in 100ml distilled water with the mixing of 5mL Tween-80, extract ingredient with extraction, remove extractant, obtain the total composition of drug extract；
(2) total for drug extract composition is dissolved in 200ml distilled water, mix homogeneously, decoct 30 minutes, leach；Boil second time again and add 800ml distilled water, decoct 50 minutes, filter, concentration；
(3) concentrated solution is circulated 3 times on high pressure homogenizer, first class pressure 120Mpa, secondary pressure 50Mpa, adjust pH to 5-7, filter；
(4) filtrate after above-mentioned concentration adding the ethanol of 95%, makes alcohol content reach 60%, precipitate with ethanol overnight, filters, and filtrate recycling ethanol obtains alcohol deposit fluid, reclaims ethanol, and being concentrated into proportion is 1.01-1.03；
(5) by sterilizing 30min at above-mentioned concentrated solution 100 DEG C, whole process inflated with nitrogen is protected；
(6) subpackage, must treat the nasal drop of rhinitis.
Embodiment 3
A kind of nasal drop treating rhinitis, counts by weight, by Herba Menthae 15 parts, hides Herba Lepisori Thunbergiani 5 parts, mountain Herba rutae 4 parts, Semen Caesalpiniae Minacis 2 parts, 2 parts of Radix Glycyrrhizae, and Tween-80 5ml forms.
The preparation method of the nasal drop of above-mentioned treatment rhinitis, concrete preparation process is as follows:
(1) by Herba Menthae, hide Herba Lepisori Thunbergiani, mountain Herba rutae, Semen Caesalpiniae Minacis and Radix Glycyrrhizae cleaning after drying, be ground into coarse powder, add in 100ml distilled water with the mixing of 5mL Tween-80, extract ingredient with extraction, remove extractant, obtain the total composition of drug extract；
(2) total for drug extract composition is dissolved in 200ml distilled water, mix homogeneously, decoct 30 minutes, leach；Boil second time again and add 800ml distilled water, decoct 50 minutes, filter, concentration；
(3) concentrated solution is circulated 3 times on high pressure homogenizer, first class pressure 150Mpa, secondary pressure 50Mpa, adjust pH to 5-7, filter；
(4) filtrate after above-mentioned concentration adding the ethanol of 95%, makes alcohol content reach 60%, precipitate with ethanol overnight, filters, and filtrate recycling ethanol obtains alcohol deposit fluid, reclaims ethanol, and being concentrated into proportion is 1.01-1.03；
(5) by sterilizing 30min at above-mentioned concentrated solution 100 DEG C, whole process inflated with nitrogen is protected；
(6) subpackage, must treat the nasal drop of rhinitis.
Embodiment 4
A kind of nasal drop treating rhinitis, counts by weight, by Herba Menthae 15 parts, hides Herba Lepisori Thunbergiani 5 parts, mountain Herba rutae 5 parts, Semen Caesalpiniae Minacis 3 parts, 3 parts of Radix Glycyrrhizae, and Tween-80 5ml forms.
The preparation method of the nasal drop of above-mentioned treatment rhinitis, concrete preparation process is as follows:
(1) by Herba Menthae, hide Herba Lepisori Thunbergiani, mountain Herba rutae, Semen Caesalpiniae Minacis and Radix Glycyrrhizae cleaning after drying, be ground into coarse powder, add in 100ml distilled water with the mixing of 5mL Tween-80, extract ingredient with extraction, remove extractant, obtain the total composition of drug extract；
(2) total for drug extract composition is dissolved in 200ml distilled water, mix homogeneously, decoct 30 minutes, leach；Boil second time again and add 800ml distilled water, decoct 60 minutes, filter, concentration；
(3) concentrated solution is circulated 3 times on high pressure homogenizer, first class pressure 150Mpa, secondary pressure 50Mpa, adjust pH to 5-7, filter；
(4) filtrate after above-mentioned concentration adding the ethanol of 95%, makes alcohol content reach 60%, precipitate with ethanol overnight, filters, and filtrate recycling ethanol obtains alcohol deposit fluid, reclaims ethanol, and being concentrated into proportion is 1.01-1.03；
(5) by sterilizing 30min at above-mentioned concentrated solution 100 DEG C, whole process inflated with nitrogen is protected；
(6) subpackage, must treat the nasal drop of rhinitis.
The present invention contrasts ear swelling experiment:
Experiment material:
Animal: similar white mice 80, body weight 25-30g.
Medicine and reagent: anesthetics, dimethylbenzene, normal saline.
Experimental technique:
Taking same kind white mice 80 at random, be randomly divided into 4 groups, often group 20, is spread evenly across two sides before and after mouse right ear respectively under anesthetics effect by dimethylbenzene, and left ear is not coated with, and after causing scorching half an hour after, first group with normal saline, even spread mouse right ear；Second group with the nasal drop in embodiment 1, even spread mouse right ear；3rd group with the nasal drop in embodiment 2, even spread mouse right ear；4th group with the nasal drop in embodiment 3, even spread mouse right ear；5th group with the nasal drop in embodiment 4, even spread mouse right ear；After causing scorching 5h, being put to death by de-for mice neck, cut left and right two ears, lay circular auricle with 5mm card punch respectively at the two same positions of ear, precision weighs auricle weight, calculates swelling rate and inhibitory rate of intumesce.
Ear swelling suppression ratio experimental result:
| Group | Left auricle weight (mg) | Auris dextra tablet weight (mg) | Swelling rate (%) | Inhibitory rate of intumesce (%) |
| First group | 13.5±0.8 | 25.5±2.8 | 92.2 | 7.8 |
| Second group | 13.4±1.1 | 19.6±1.5 | 46.3 | 53.7 |
| 3rd group | 13.6±1.1 | 19.7±1.4 | 44.8 | 55.2 |
| 4th group | 13.5±1.0 | 19.4±1.2 | 43.7 | 56.3 |
| 5th group | 13.5±0.8 | 19.3±1.1 | 42.9 | 57.1 |
Utilize technical solutions according to the invention, or those skilled in the art is under the inspiration of technical solution of the present invention, design similar technical scheme, and reach above-mentioned technique effect, all fall into protection scope of the present invention.
Claims (4)
1. the nasal drop treating rhinitis, it is characterised in that: by Herba Menthae 13-15 part, hiding Herba Lepisori Thunbergiani 3-5 part, mountain Herba rutae 3-5 part, Semen Caesalpiniae Minacis 2-3 part, Radix Glycyrrhizae 2-3 part, Tween-80 5ml forms.
2. the nasal drop for the treatment of rhinitis according to claim 1, it is characterised in that: prepared by following method:
(1) by Herba Menthae, hide Herba Lepisori Thunbergiani, mountain Herba rutae, Semen Caesalpiniae Minacis and Radix Glycyrrhizae cleaning after drying, be ground into coarse powder, add in 100ml distilled water with the mixing of 5mL Tween-80, extract ingredient with extraction, remove extractant, obtain the total composition of drug extract；
(2) total for drug extract composition is dissolved in 200ml distilled water, mix homogeneously, decoct 30 minutes, leach；Boil second time again and add 800ml distilled water, decoct 60 minutes, filter, concentration；
(3) concentrated solution is circulated 3 times on high pressure homogenizer, first class pressure 150Mpa, secondary pressure 50Mpa, adjust pH to 5-7, filter；
(4) filtrate after above-mentioned concentration adding the ethanol of 95%, makes alcohol content reach 60%, precipitate with ethanol overnight, filters, and filtrate recycling ethanol obtains alcohol deposit fluid, reclaims ethanol, and being concentrated into proportion is 1.01-1.03；
(5) by sterilizing 30min at above-mentioned concentrated solution 100 DEG C, whole process inflated with nitrogen is protected；
(6) subpackage, must treat the nasal drop of rhinitis.
3. the nasal drop for the treatment of rhinitis according to claim 1 and 2, it is characterised in that: counting by weight, by Herba Menthae 14-15 part, hide Herba Lepisori Thunbergiani 4-5 part, mountain Herba rutae 4-5 part, Semen Caesalpiniae Minacis 2-3 part, Radix Glycyrrhizae 2-3 part, Tween-80 5ml forms.
4. the nasal drop for the treatment of rhinitis according to claim 3, it is characterised in that: counting by weight, by Herba Menthae 15 parts, hide Herba Lepisori Thunbergiani 5 parts, mountain Herba rutae 5 parts, Semen Caesalpiniae Minacis 3 parts, 3 parts of Radix Glycyrrhizae, Tween-80 5ml forms.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410840534.5A CN105796657A (en) | 2014-12-30 | 2014-12-30 | Nasal drop for treating rhinitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410840534.5A CN105796657A (en) | 2014-12-30 | 2014-12-30 | Nasal drop for treating rhinitis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109521106A (en) * | 2018-10-26 | 2019-03-26 | 健民药业集团股份有限公司 | Method that is a kind of while detecting four kinds of component contents in five composition granule of Radix Astragali ramulus cinnamomi |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103505414A (en) * | 2012-06-28 | 2014-01-15 | 石药集团恩必普药业有限公司 | Butylphthalide nasal drop and preparation method thereof |
| CN104001050A (en) * | 2014-05-27 | 2014-08-27 | 马忠伟 | Traditional Chinese medicine nose drops for treating allergic rhinitis |
-
2014
- 2014-12-30 CN CN201410840534.5A patent/CN105796657A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103505414A (en) * | 2012-06-28 | 2014-01-15 | 石药集团恩必普药业有限公司 | Butylphthalide nasal drop and preparation method thereof |
| CN104001050A (en) * | 2014-05-27 | 2014-08-27 | 马忠伟 | Traditional Chinese medicine nose drops for treating allergic rhinitis |
Non-Patent Citations (1)
| Title |
|---|
| 魏太星: "《最新临床药物手册》", 31 January 1999, 中原农民出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109521106A (en) * | 2018-10-26 | 2019-03-26 | 健民药业集团股份有限公司 | Method that is a kind of while detecting four kinds of component contents in five composition granule of Radix Astragali ramulus cinnamomi |
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Application publication date: 20160727 |