CN105753869B - 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 - Google Patents
一种cdk抑制剂和mek抑制剂的共晶及其制备方法 Download PDFInfo
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Description
化合物 | MEK162与LEE011共晶 |
MEK162浓度(mmol/L) | 0.128 |
LEE011浓度(mmol/L) | 0.131 |
摩尔比 | 1∶1 |
化合物 | MEK162/LEE011组分 |
MEK162浓度(mmol/L) | 0.157 |
LEE011浓度(mmol/L) | 0.153 |
摩尔比 | 1∶1 |
起始晶型 | 放置条件 | 放置时间 | 晶型变化 |
晶型I | 25℃/60%RH | 14天 | 晶型I保持不变(如图12) |
晶型I | 40℃/75%RH | 14天 | 晶型I保持不变(如图13) |
起始晶型 | 放置条件 | 放置时间 | 晶型变化 |
晶型II | 25(±3)℃/25%RH | 2天 | 晶型II变成晶型I(如图21) |
起始晶型 | 放置条件 | 放置时间 | 晶型变化 |
晶型III | 25℃/60%RH | 30天 | 晶型III保持不变(如图14) |
晶型III | 40℃/75%RH | 30天 | 晶型III保持不变(如图15) |
Claims (17)
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Publication number | Priority date | Publication date | Assignee | Title |
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WO2014018725A1 (en) * | 2012-07-26 | 2014-01-30 | Novartis Ag | Pharmaceutical combinations of a cdk4/6 inhibitor and a b-raf inhibitor |
WO2014097125A1 (en) * | 2012-12-20 | 2014-06-26 | Novartis Ag | Pharmaceutical combination comprising binimetinib |
WO2014147573A2 (en) * | 2013-03-21 | 2014-09-25 | Novartis Ag | Combination therapy |
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WO2014018725A1 (en) * | 2012-07-26 | 2014-01-30 | Novartis Ag | Pharmaceutical combinations of a cdk4/6 inhibitor and a b-raf inhibitor |
WO2014097125A1 (en) * | 2012-12-20 | 2014-06-26 | Novartis Ag | Pharmaceutical combination comprising binimetinib |
WO2014147573A2 (en) * | 2013-03-21 | 2014-09-25 | Novartis Ag | Combination therapy |
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