CN105749330A - Gel state wound dressing for trauma - Google Patents
Gel state wound dressing for trauma Download PDFInfo
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- CN105749330A CN105749330A CN201610092791.4A CN201610092791A CN105749330A CN 105749330 A CN105749330 A CN 105749330A CN 201610092791 A CN201610092791 A CN 201610092791A CN 105749330 A CN105749330 A CN 105749330A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
The invention provides a gel state wound dressing for trauma. Main components of the gel state wound dressing for the trauma comprise polyhexamethylene biguanidine hydrochloride and cocoalkanoylamido propyl betaine, wherein the content of the polyhexamethylene biguanidine hydrochloride is 0.1 to 1 mass percent, and the content of the cocoalkanoylamido propyl betaine is 0.1 to 1.5 mass percent; the wound dressing also comprises a gel, and water is used as solvent. The gel state wound dressing provided by the invention has the advantages of lower toxicity, good tolerance, no irritation, higher antibacterial activity as well as efficacy of alleviating pain, reducing peculiar smell of wound and promoting wound healing.
Description
Technical field
The present invention relates to medical instruments field, particularly relate to the outer wound surgical dressing of a kind of gel state.
Background technology
The skin soft tissue wounds such as open wound, soft tissue infection's ulceration mouth, operative incision, it is necessary to carry out treatment of wounds to ensure the cleaning of wound, aseptic, promote promote granulation growth, promote wound healing.For the process of above-mentioned wound, it is generally required to carry out debridement and process of changing dressings.The gel state dressing used when changing dressings generally is referred to as the outer wound surgical dressing of gel state.
The application of the outer wound surgical dressing of current gel state is very extensive, and this kind of dressing can make wound keep moist environment, and sterilizing is antibacterial, certain closing wound can also be played, make the effect of itself and external environment isolation, it is possible to effectively facilitate granulation tissue growth, promote the healing of wound.Application comparison wound dressing widely generally has silver ion dressing, chitosan dressing, chemosterilant dressing and gel sponge class dressing etc. several on the market at present.Silver ion dressing and chitosan dressing mainly using silver ion or chitosan as biocide, are aided with other dispensing.Through present medical research, silver ion and chitosan all have certain toxicity, although it all has good sterilizing and antibacterial effect, but skin soft tissue is all had and injures definitely, the health of patient can be worked the mischief by abuse, thus the control of current this kind of dressing is very strict.Chemosterilant dressing is then main with chemicals for biocide, equally also has good sterilizing and antibacterial effect.But current chemosterilant is primarily present problem below: first, most of chemicals all have certain zest, can increase the pain of patient, and some patients also has anaphylaxis；Secondly, most chemicals does not suppress and treatment effect for soft tissue transudate, uses this kind of dressing wound abnormal flavour bigger；Finally, chemical classes preparation generally all lacks the effect promoting granulation tissue growth, it is impossible to make wound healing.And what gel sponge class dressing mainly used when wound drainage, it is necessary to coordinating negative pressure to use, range of application is narrower, and price is also sufficiently expensive.
Summary of the invention
The technical problem to be solved is aiming at the deficiency of above-mentioned background technology, there is provided a kind of gel state outer wound surgical dressing, there is low toxicity, good toleration and tack, and nonirritant, there is relatively high antibacterial activity, moreover it is possible to have and slow down pain, reduction wound abnormal flavour and promote effect of wound healing.
For solving above-mentioned technical problem, the outer wound surgical dressing of gel state provided by the invention, the outer wound surgical dressing main component of described gel state includes hexamethylene and cocamido propyl betaine, wherein the weight/mass percentage composition of hexamethylene is 0.1% ~ 1.5%, and the weight/mass percentage composition of cocamido propyl betaine is 0.1% ~ 1.5%；Described wound dressing also includes gel, and solvent is water.
In technique scheme, the weight/mass percentage composition of described hexamethylene preferably 0.15% ~ 0.85%, it is most preferred that 0.42% ~ 0.58%.
In technique scheme, the weight/mass percentage composition of described cocamido propyl betaine preferably 0.15% ~ 0.85%, it is preferred that 0.52% ~ 0.62%, it is most preferred that 0.55% ~ 0.58%.
In technique scheme, described gel preferred mass percentage composition is the chitosan of 0.5% ~ 2%, it is most preferred that weight/mass percentage composition is the chitosan of 1% ~ 1.5%.
In technique scheme, the outer wound surgical dressing of described gel state also includes wetting agent, and the weight/mass percentage composition of described wetting agent is 12% ~ 18%.
In technique scheme, described wetting agent preferably glycerine.
Compared with prior art, the beneficial effects of the present invention is: 1) adopt appropriate hexamethylene as biocide, while taking into account sterilizing and be antibacterial, it is ensured that dressing has low toxicity, good toleration, and sensitization is extremely low；2) use cocamido propyl betaine as surfactant, and have employed applicable consumption, zest is extremely low and has certain bactericidal effect concurrently, and this material can also keep wettability and the pliability of skin soft tissue, it is possible to wound healing has very strong facilitation；3) mixing of above two material uses, moreover it is possible to the abnormal flavour effectively reducing wound produces；4) showing through clinic, inventive formulation also has the effect of inhibition of pain sense, it is possible to effectively reduce the misery of patient.
Detailed description of the invention
It is described in further detail below in conjunction with specific embodiments of the invention:
The outer wound surgical dressing of gel state designed by the present invention, the outer wound surgical dressing main component of described gel state includes hexamethylene and cocamido propyl betaine, wherein the weight/mass percentage composition of hexamethylene is 0.1% ~ 1.5%, and the weight/mass percentage composition of cocamido propyl betaine is 0.1% ~ 1.5%；Described wound dressing also includes gel, and solvent is water.In actual disposition process, due to the relation of material purity, inevitably also have certain impurity and exist.
Through inventor's clinical research for many years, hexamethylene has good sterilizing and antibacterial effect, is very suitable for for wound dressing.But the handle control for consumption is very crucial, and dosage is crossed conference and caused that it has toxicity and zest, the too small effect not reaching again preventing and treating wound infection of dosage.Inventor is after substantial amounts of sterilizing experiment and toxicity test, it has been found that hexamethylene weight/mass percentage composition controls in 0.1% ~ 2% interval, it is possible to effectively play sterilizing and antibacterial effect, and toxicity is also within acceptable scope simultaneously.
When carrying out the studies above, inventor have found that the simple healing selecting hexamethylene can not well promote wound surface, thus select which kind of assistant medicament matched, also key very.After inventor have passed through substantial amounts of experiment and combination selection, it has been found that cocamido propyl betaine coordinates with hexamethylene can play good effect.In this stage research process, inventor have found that when the two combination uses, fungistatic effect is fairly obvious, when the two combination uses, it is possible to reduce the consumption of hexamethylene further, reduce the toxicity of whole dressing.The weight/mass percentage composition of hexamethylene is 0.1% ~ 1.5%, when the weight/mass percentage composition of cocamido propyl betaine is 0.1% ~ 1.5%, product not only has fabulous sterilization effect, and toxicity also reduces significantly than being used alone poly-hexamethyl biguanide hydrochloride.Carry out in zoopery and clinical experiment process follow-up, inventor is also found surprisingly that both with the use of playing softening skin soft tissue, keeping the effect of wound moist degree, it is possible to promote wound healing, the two is utilized in conjunction with there is the effect reducing pain clinically simultaneously.
Through the studies above, inventor optimizes formula further.
The weight/mass percentage composition of hexamethylene described in inventive formulation preferably 0.15% ~ 0.85%, it is most preferred that 0.42% ~ 0.58%.
The weight/mass percentage composition of cocamido propyl betaine described in inventive formulation preferably 0.15% ~ 0.85%, it is preferred that 0.52% ~ 0.62%, it is most preferred that 0.55% ~ 0.58%.
The present invention adopts gel preparations, mainly considers that gel state dressing can be attached at wound surface, can play isolation wound and avoid the effect of outside germ contamination wound.Thus the consumption of gel is more crucial equally, the addition of gel needs to ensure that product has certain viscosity, it is possible to good is attached to wound, can not affect again the main component effect to wound of dressing simultaneously.Inventor finally found that selection chitosan is that ratio is better suited as gel.Gel preferred mass percentage composition is the chitosan of 0.5% ~ 2%, it is most preferred that weight/mass percentage composition is the chitosan of 1% ~ 1.5%.Adopt this kind of gel to enable to dressing as clear as crystal, slightly yellowing, and have good adhesiving effect.Adopting trace chitosan not only can reach the purpose of plastic, and the chitosan of this content does not have Side effect, and chitosan is biological species macromole, compares to chemical classes gel, zest is lower, and sensitization is also lower.
Although cocamido propyl betaine coordinates with hexamethylene can play the effect keeping wound moist degree, but the dressing wettability of gel state is limited.In order to enable better to keep wettability, the present invention can also add wetting agent that weight/mass percentage composition is 12% ~ 18% in order to be humidified, it is possible to advantageously promotes the healing of wound.Described gel can select glycerol, propylene glycol, sorbitol etc., it is preferable that glycerol.
The embodiment of the present invention:
Embodiment 1: the outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 0.1%, cocamido propyl betaine weight/mass percentage composition 0.1%.Described gel is chitosan, weight/mass percentage composition 2%.Finally encapsulation, sterilizing obtains final products.
Embodiment 2:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 0.15%, cocamido propyl betaine weight/mass percentage composition 0.24%.Described gel is chitosan, weight/mass percentage composition 2%.Finally encapsulation, sterilizing obtains final products.
Embodiment 3:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 0.22%, cocamido propyl betaine weight/mass percentage composition 0.15%.Described gel is chitosan, weight/mass percentage composition 1.5%.Finally encapsulation, sterilizing obtains final products.
Embodiment 4:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 0.42%, cocamido propyl betaine weight/mass percentage composition 0.52%.Described gel is chitosan, weight/mass percentage composition 1.5%.Finally encapsulation, sterilizing obtains final products.
Embodiment 5:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 0.58%, cocamido propyl betaine weight/mass percentage composition 0.62%.Described gel is chitosan, weight/mass percentage composition 1%.Also need the glycerol adding 12% as wetting agent simultaneously.Finally encapsulation, sterilizing obtains final products.
Embodiment 6:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 0.55%, cocamido propyl betaine weight/mass percentage composition 0.55%.Described gel is chitosan, weight/mass percentage composition 1%.Also need the glycerol adding 14% as wetting agent simultaneously.Finally encapsulation, sterilizing obtains final products.
Embodiment 7:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 0.45%, cocamido propyl betaine weight/mass percentage composition 0.58%.Described gel is chitosan, weight/mass percentage composition 0.5%.Also need the glycerol adding 16% as wetting agent simultaneously.Finally encapsulation, sterilizing obtains final products.
Embodiment 8:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 0.85%, cocamido propyl betaine weight/mass percentage composition 0.85%.Described gel is chitosan, weight/mass percentage composition 0.5%.Also need the glycerol adding 18% as wetting agent simultaneously.Finally encapsulation, sterilizing obtains final products.
Embodiment 9:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 1.2%, cocamido propyl betaine weight/mass percentage composition 1.2%.Described gel is chitosan, weight/mass percentage composition 1.2%.Also need the propylene glycol adding 14% as wetting agent simultaneously.Finally encapsulation, sterilizing obtains final products.
Embodiment 10:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 1.5%, cocamido propyl betaine weight/mass percentage composition 1%.Described gel is chitosan, weight/mass percentage composition 1.4%.Also need the propylene glycol adding 16% as wetting agent simultaneously.Finally encapsulation, sterilizing obtains final products.
Embodiment 11:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 1%, cocamido propyl betaine weight/mass percentage composition 1.5%.Described gel is chitosan, weight/mass percentage composition 1.5%.Also need the sorbitol adding 15% as wetting agent simultaneously.Finally encapsulation, sterilizing obtains final products.
Embodiment 12:The outer wound surgical dressing of a kind of gel state, including hexamethylene and cocamido propyl betaine, add water and be configured to solution shape so that it is middle hexamethylene weight/mass percentage composition 0.48%, cocamido propyl betaine weight/mass percentage composition 0.56%.Described gel is chitosan, weight/mass percentage composition 1.5%.Also need the sorbitol adding 18% as wetting agent simultaneously.Finally encapsulation, sterilizing obtains final products.
Application examples of the present invention:
Zoopery 1:With embodiment of the present invention product, rabbit being sticked experiment, result shows: experimental rabbit is showed no the symptoms such as discharge, erythema, edema；Tissue slice is observed and is shown, shows no obvious abnormalities.It is judged to nonirritant product.
Zoopery 2:With embodiment of the present invention product, Cavia porcellus is sticked test, carry out system test and scoring according to the relevant regulations of GB/T16866,10-2005.Result shows: experimental guinea pig all occurred without delayed hypersensitivity in 48 hours.
Zoopery 3:With embodiment of the present invention product for experimental group product, for matched group product, rabbit being sticked experiment with the chitosan dressing generally sold on the market and chemicals dressing, result shows: adopt the wound healing time of the experimental group rabbit of product of the present invention to shorten more than 20% than matched group rabbit.
Clinical practice example:Carrying out clinical research under meeting country's relevant laws and regulations premise, result shows: being used alone this product and can improve rapidly the wound situation of patient, infection rate substantially reduces, and after not finding to apply this product, allergy or systemic reaction occurs.Patient generally experiences comfortable, and dressing adhesiveness is better, it is easy to accept, and after patient generally feels to use this product, pain has obvious improvement.
The core of the present invention is to utilize hexamethylene and cocamido propyl betaine to prepare the outer wound surgical dressing of gel state for main component; play preventing and treating wound infection; promote wound healing; and the effect that effectively reduction of patient is painful; therefore; on the basis of the principle of the invention, any change utilizing above-mentioned mechanism or deformation, belong to protection scope of the present invention.
Claims (10)
1. the outer wound surgical dressing of gel state, it is characterized in that: the outer wound surgical dressing main component of described gel state includes hexamethylene and cocamido propyl betaine, wherein the weight/mass percentage composition of hexamethylene is 0.1% ~ 1.5%, and the weight/mass percentage composition of cocamido propyl betaine is 0.1% ~ 1.5%；Described wound dressing also includes gel, and solvent is water.
2. the outer wound surgical dressing of gel state according to claim 1, it is characterised in that: the weight/mass percentage composition of described hexamethylene is 0.15% ~ 0.85%.
3. the outer wound surgical dressing of gel state according to claim 2, it is characterised in that: the weight/mass percentage composition of described hexamethylene is 0.42% ~ 0.58%.
4. the outer wound surgical dressing of gel state according to claim 1, it is characterised in that: the weight/mass percentage composition of described cocamido propyl betaine is 0.15% ~ 0.85%.
5. the outer wound surgical dressing of gel state according to claim 4, it is characterised in that: the weight/mass percentage composition of described cocamido propyl betaine is 0.52% ~ 0.62%.
6. the outer wound surgical dressing of gel state according to claim 5, it is characterised in that: the weight/mass percentage composition of described cocamido propyl betaine is 0.55% ~ 0.58%.
7. the outer wound surgical dressing of gel state according to claim 1 ~ 6, it is characterised in that: described gel is weight/mass percentage composition is the chitosan of 0.5% ~ 2%.
8. the outer wound surgical dressing of gel state according to claim 7, it is characterised in that: described gel is weight/mass percentage composition is the chitosan of 1% ~ 1.5%.
9. the outer wound surgical dressing of gel state according to claim 1 ~ 6, it is characterised in that: the outer wound surgical dressing of described gel state also includes wetting agent, and the weight/mass percentage composition of described wetting agent is 12% ~ 18%.
10. the outer wound surgical dressing of gel state according to claim 9, it is characterised in that: described wetting agent is glycerol.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610092791.4A CN105749330A (en) | 2016-02-19 | 2016-02-19 | Gel state wound dressing for trauma |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610092791.4A CN105749330A (en) | 2016-02-19 | 2016-02-19 | Gel state wound dressing for trauma |
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| CN105749330A true CN105749330A (en) | 2016-07-13 |
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| CN201610092791.4A Pending CN105749330A (en) | 2016-02-19 | 2016-02-19 | Gel state wound dressing for trauma |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823256A (en) * | 2017-10-20 | 2018-03-23 | 湖北中创医疗用品有限公司 | A kind of chitosan oligomer poly hexamethylene biguanide wound care film and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461368A (en) * | 2008-12-22 | 2009-06-24 | 南车戚墅堰机车车辆工艺研究所有限公司 | Spray finishing material with disinfecting and sterilizing functions |
| US20130150451A1 (en) * | 2011-12-07 | 2013-06-13 | Rochal Industries, Llp | Biocidal compositions and methods of using the same |
| CN104399082A (en) * | 2014-12-09 | 2015-03-11 | 南阳市汇博生物技术有限公司 | Nutrient gel for sterilizing and healing wound surface and preparation method of nutrient gel |
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2016
- 2016-02-19 CN CN201610092791.4A patent/CN105749330A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461368A (en) * | 2008-12-22 | 2009-06-24 | 南车戚墅堰机车车辆工艺研究所有限公司 | Spray finishing material with disinfecting and sterilizing functions |
| US20130150451A1 (en) * | 2011-12-07 | 2013-06-13 | Rochal Industries, Llp | Biocidal compositions and methods of using the same |
| CN104399082A (en) * | 2014-12-09 | 2015-03-11 | 南阳市汇博生物技术有限公司 | Nutrient gel for sterilizing and healing wound surface and preparation method of nutrient gel |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823256A (en) * | 2017-10-20 | 2018-03-23 | 湖北中创医疗用品有限公司 | A kind of chitosan oligomer poly hexamethylene biguanide wound care film and preparation method thereof |
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Application publication date: 20160713 |