CN105748927A - 一种治疗痛风性关节炎急性发作的中药制剂 - Google Patents
一种治疗痛风性关节炎急性发作的中药制剂 Download PDFInfo
- Publication number
- CN105748927A CN105748927A CN201610156745.6A CN201610156745A CN105748927A CN 105748927 A CN105748927 A CN 105748927A CN 201610156745 A CN201610156745 A CN 201610156745A CN 105748927 A CN105748927 A CN 105748927A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine preparation
- gouty arthritis
- radix
- acute attack
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 75
- 201000005569 Gout Diseases 0.000 title claims abstract description 54
- 206010018634 Gouty Arthritis Diseases 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 45
- 230000001154 acute effect Effects 0.000 title claims abstract description 44
- 229940079593 drug Drugs 0.000 claims abstract description 20
- 239000004863 Frankincense Substances 0.000 claims abstract description 15
- 241001250596 Pleione Species 0.000 claims description 17
- 239000008517 radix Trichosanthis Substances 0.000 claims description 15
- 241000717739 Boswellia sacra Species 0.000 claims description 14
- 241000283956 Manis Species 0.000 claims description 14
- 241001057584 Myrrha Species 0.000 claims description 14
- 231100000614 poison Toxicity 0.000 claims description 11
- 235000005911 diet Nutrition 0.000 claims description 7
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims description 6
- 230000037213 diet Effects 0.000 claims description 6
- 239000002574 poison Substances 0.000 claims description 6
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims description 5
- 229940116269 uric acid Drugs 0.000 claims description 5
- 230000003203 everyday effect Effects 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 230000037396 body weight Effects 0.000 claims description 3
- 230000003750 conditioning effect Effects 0.000 claims description 3
- 230000029142 excretion Effects 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 235000014102 seafood Nutrition 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 12
- 241000049624 Alisma plantago-aquatica subsp. orientale Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 1
- 240000007551 Boswellia serrata Species 0.000 abstract 1
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- 241000935235 Fritillaria meleagris Species 0.000 abstract 1
- 241000931143 Gleditsia sinensis Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241000766380 Iphigenia Species 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 241000283966 Pholidota <mammal> Species 0.000 abstract 1
- 235000008326 Trichosanthes anguina Nutrition 0.000 abstract 1
- 244000078912 Trichosanthes cucumerina Species 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 16
- 210000004369 blood Anatomy 0.000 description 16
- 208000002193 Pain Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 230000001737 promoting effect Effects 0.000 description 10
- 201000010099 disease Diseases 0.000 description 8
- 230000008961 swelling Effects 0.000 description 8
- 230000017531 blood circulation Effects 0.000 description 7
- 208000006820 Arthralgia Diseases 0.000 description 6
- 239000003440 toxic substance Substances 0.000 description 5
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 4
- 239000003172 expectorant agent Substances 0.000 description 4
- 230000003419 expectorant effect Effects 0.000 description 4
- 208000037920 primary disease Diseases 0.000 description 4
- 230000004087 circulation Effects 0.000 description 3
- 206010025482 malaise Diseases 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 208000004044 Hypesthesia Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 210000000544 articulatio talocruralis Anatomy 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 229960001338 colchicine Drugs 0.000 description 2
- 208000034783 hypoesthesia Diseases 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- QYZBCWXZSYTIOY-UHFFFAOYSA-N Mercuric oxide Chemical compound [O-2].[Hg+2] QYZBCWXZSYTIOY-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000001171 synovial bursa Anatomy 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明提供一种治疗痛风性关节炎急性发作的中药制剂,属于中药制剂技术领域,该治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药:当归6g~10g,陈皮6g~10g,浙贝母6g~10g,皂角刺6g~10g,山慈菇6g~10g,赤芍12g~15g、天花粉12g~15g,苍术12g~15g,黄柏12g~15g,萆薢12g~15g,泽泻12g~15g,川牛膝12g~15g,乳香4g~6g,没药4g~6g,甘草4g~6g,穿山甲3g~5g。本发明药物治疗治疗痛风性关节炎急性发作疗效显著,经临床试验证明,无毒副作用,治愈率高,治疗成本低,复发率不高,适合推广应用。
Description
技术领域
本发明属于中药制剂技术领域,尤其涉及一种治疗痛风性关节炎急性发作的中药制剂。
背景技术
痛风是嘌呤代谢紊乱及(或)尿酸***减少所引起的一组代谢性疾病。痛风性关节炎是大多数痛风患者最初和最常见的临床表现。本病初发年龄大多在40岁左右,男性多见,急性期有骤然发作和剧烈关节疼痛肿胀的特征,多数患者的关节炎表现为发作与缓解交替,病程长者发作期长而缓解期短,有的甚至迁延不愈,表现慢性痛风、石性痛风。近年来,随着生活水平的日益提高和饮食结构的改变,痛风性关节炎的发病率明显上升,并有逐渐年轻化的趋势,是临床难治病之一。
痛风性关节炎是尿酸盐结晶沉积在关节滑膜、滑囊、软骨及其他组织中引起的反复发作性炎症性疾病。该病在欧美国家发病率较高,在我国以往较少见。但随着人民生活水平改善及诊疗水平提高,其发病率有增高趋势。。
但是,现代医学应用秋水仙碱等药物可较快地控制急性症状,但因其副作用大,且不能治愈本病,患者往往难以坚持治疗,故复发率也很高,所以,人们越来越多地寻求中医药治疗
因此,发明一种治疗痛风性关节炎急性发作的中药制剂显得非常必要。
发明内容
为了解决上述技术问题,本发明提供一种治疗痛风性关节炎急性发作的中药制剂,以解决现有治疗痛风性关节炎急性发作药物存在着副作用大,且不能治愈本病,患者往往难以坚持治疗,故复发率也很高的问题。一种治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药:当归6g~10g,陈皮6g~10g,浙贝母6g~10g,皂角刺6g~10g,山慈菇6g~10g,赤芍12g~15g、天花粉12g~15g,苍术12g~15g,黄柏12g~15g,萆薢12g~15g,泽泻12g~15g,川牛膝12g~15g,乳香4g~6g,没药4g~6g,甘草4g~6g,穿山甲3g~5g。
优选地,所述的治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药:当归10g~15g,陈皮10g~15g,浙贝母10g~15g,皂角刺10g~15g,山慈菇10g~15g,赤芍15g~20g、天花粉15g~20g,苍术15g~20g,黄柏15g~20g,萆薢15g~20g,泽泻15g~20g,川牛膝15g~20g,乳香6g~8g,没药6g~8g,甘草6g~8g,穿山甲5g~8g。
优选地,所述的治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药优选配比为:当归、陈皮、浙贝母、皂角刺、山慈菇各10g,赤芍、天花粉、苍术、黄柏、萆薢、泽泻、川牛膝各15g,乳香、没药、甘草各6g,穿山甲5g。
优选地,所述的治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药优选配比为:当归、陈皮、浙贝母、皂角刺、山慈菇各6g,赤芍、天花粉、苍术、黄柏、萆薢、泽泻、川牛膝各12g,乳香、没药、甘草各4g,穿山甲3g。
优选地,所述的治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药优选配比为:当归、陈皮、浙贝母、皂角刺、山慈菇各15g,赤芍、天花粉、苍术、黄柏、萆薢、泽泻、川牛膝各20g,乳香、没药、甘草、穿山甲各8g。
优选地,所述的治疗痛风性关节炎急性发作的中药制剂采用水煎内服,每日1剂,煎2汁,分早、晚2次温服,7天为1个疗程。
优选地,所述的治疗痛风性关节炎急性发作的中药制剂采用仙方活命饮加减。所述的仙方活命饮出自《校注妇人良方》,具有清热解毒,消肿溃坚,活血化瘀,理气止痛的功效,仙方活命饮专为实热疮疡而设,因该方组方严谨,配伍精当,活血化瘀而不伤正,散结消肿通络行滞而不伤阴,诸药合用温凉相抵,唯行散之力卓著。
优选地,所述的治疗痛风性关节炎急性发作的中药制剂服药后注意事项:注重调理饮食,限制膏粱厚味,忌酒、咖啡、海鲜、动物内脏及酸性食物,饮食宜清淡;多饮水,增加尿酸浊毒的***;肥胖患者应减肥,保持适中体重。
祖国医学中亦有“痛风”之病名,如朱丹溪《格致余论》就曾列痛风专篇,还相当于祖国医学“痛痹”、“历节”、“脚气”等症。其病因病机历代各家都有论述。朱丹溪《格致余论》载:“痛风者,大率因血受热已自沸腾,其后或涉冷水,或立湿地……寒凉外搏,热血得寒汗浊凝滞,所以作痛,夜则痛甚,行于阴也”。唐·王涛《外台秘要》认为本病“大多是风寒暑湿之毒,因虚所致,将摄失理,受此风邪,经络结滞,蓄于关节之间,或在四肢,其痰昼静而夜发,发时彻骨绞痛”“急则倾泄浊毒,利湿化瘀”。由于痛风性关节炎主要临床表现为病变关节红、肿、热、痛,活动障碍,尤以第一跖趾、跗或踝关节多发,一部分患者伴有发热、心烦口渴、舌红、苔黄,按其证候分析属中医学痹病中“热痹”或“痛痹”范畴。其病因病机多认为与痰瘀湿浊热毒有关,由于过食肥甘滋腻之品或过度饮酒,蕴湿生痰化热,湿热痰浊下注,痹阻关节经络,导致气血流通不畅,不通则痛,故而多见足、踝关节红、肿、热、痛症状,如长期不愈,反复发作,可使关节出现不同程度的骨质破坏与功能障碍。本病患者均有膝部灼热肿痛,舌红苔黄,脉弦滑等症状。除瘀血外与中医“湿热痹”极为相似。
所述的治疗痛风性关节炎急性发作的中药制剂中穿山甲气腥而窜,其走窜之性无微不至,故能宣通脏腑,贯彻经络,透达关窍,凡血凝血聚为病,皆能开之;白芷、防风透达营卫,散结消肿;乳香、没药气香,香能走窜而善行,故能行血散瘀,利气通络,血行气利则疼痛自止;当归尾、赤芍活血散瘀,消肿止痛;苍术、薏苡仁健脾利湿除痹;血瘀之处必有伏阳,故以金银花、天花粉、黄柏清之,黄柏兼燥湿作用;贝母、天花粉同用,协助清热散结消肿;陈皮行气通络,《本草纲目》谓本品“同补药则补,同泻药则泻,同升药则升,同降药则降”,方中配伍应用加强活血消肿之功;川牛膝活血化瘀,引药下行;痛甚之时,气脉必急,故以甘草缓之,甘草兼调和诸药。土茯苓为君药,清热利湿降浊,能入络搜剔湿热之蕴毒。萆薢为臣药,分清泌浊,有除湿、解毒、利关节功能。山慈姑为佐药,味甘、微辛、性寒,入肝、脾经,有清热、解毒、消肿、散结、化痰,促痰瘀消散的作用。加强主药清热解毒,消肿散结之力。诸药合用共奏清热燥湿,活血化瘀,消肿止痛之效。所述的治疗痛风性关节炎急性发作的中药制剂山慈菇、薏苡仁清热解毒、利湿化浊,二药均有增加尿酸有效***的作用,且山慈菇含秋水仙碱能有效缓解痛风发作。研究表明,车前子、山慈姑有一定排尿酸作用,秦艽、伸筋草可解除尿酸性疼痛B%C,所述的治疗痛风性关节炎急性发作的中药制剂中选用此类药不仅能有效提高治疗效果、控制复发,也体现了辨证与辨病治疗相结合的原则。
与现有技术相比,本发明具有如下有益效果:由于本发明的一种治疗痛风性关节炎急性发作的中药制剂广泛应用于治疗痛风性关节炎急性发作。本发明的中药制剂经临床试验证明,无毒副作用,治愈率高,疗效显著,治疗成本低,复发率不高,适合推广应用。
具体实施方式
下面结合实施例对本发明做进一步说明。
实施例1
一种治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药:当归、陈皮、浙贝母、皂角刺、山慈菇各6g,赤芍、天花粉、苍术、黄柏、萆薢、泽泻、川牛膝各12g,乳香、没药、甘草各4g,穿山甲3g。
实施例2
一种治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药:当归、陈皮、浙贝母、皂角刺、山慈菇各10g,赤芍、天花粉、苍术、黄柏、萆薢、泽泻、川牛膝各15g,乳香、没药、甘草各6g,穿山甲5g。
实施例3
一种治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药:当归、陈皮、浙贝母、皂角刺、山慈菇各15g,赤芍、天花粉、苍术、黄柏、萆薢、泽泻、川牛膝各20g,乳香、没药、甘草、穿山甲各8g。
本发明实施例中的中药制剂采用水煎内服,每日1剂,煎2汁,分早、晚2次温服,7天为1个疗程;本发明实施例中的中药制剂服药后注意事项:注重调理饮食,限制膏粱厚味,忌酒、咖啡、海鲜、动物内脏及酸性食物,饮食宜清淡;多饮水,增加尿酸浊毒的***;肥胖患者应减肥,保持适中体重。
临床疗效验证:
(1)临床观察
采用本发明治疗80例患者,其中男40例,女40例;年龄最大者65岁,年龄最小者21岁。
(2)治疗方法
采用水煎内服,每日1剂,煎2汁,分早、晚2次温服,7天为1个疗程。
(3)治疗结果
在80例患者中,服药后多在3-15天见效,经1至2个疗程,治愈率为86%。
临床试验结果表明,本发明药物治疗痛风性关节炎急性发作效显著,经临床试验证明,无毒副作用,治愈率高,疗效显著,治疗成本低,复发率不高,适合推广应用。
利用本发明所述的技术方案,或本领域的技术人员在本发明技术方案的启发下,设计出类似的技术方案,而达到上述技术效果的,均是落入本发明的保护范围。
Claims (8)
1.一种治疗痛风性关节炎急性发作的中药制剂,其特征在于,该治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药:当归6g~10g,陈皮6g~10g,浙贝母6g~10g,皂角刺6g~10g,山慈菇6g~10g,赤芍12g~15g、天花粉12g~15g,苍术12g~15g,黄柏12g~15g,萆薢12g~15g,泽泻12g~15g,川牛膝12g~15g,乳香4g~6g,没药4g~6g,甘草4g~6g,穿山甲3g~5g。
2.如权利要求1所述的治疗痛风性关节炎急性发作的中药制剂,其特征在于,所述的治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药:当归10g~15g,陈皮10g~15g,浙贝母10g~15g,皂角刺10g~15g,山慈菇10g~15g,赤芍15g~20g、天花粉15g~20g,苍术15g~20g,黄柏15g~20g,萆薢15g~20g,泽泻15g~20g,川牛膝15g~20g,乳香6g~8g,没药6g~8g,甘草6g~8g,穿山甲5g~8g。
3.如权利要求1所述的治疗痛风性关节炎急性发作的中药制剂,其特征在于,所述的治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药优选配比为:当归、陈皮、浙贝母、皂角刺、山慈菇各10g,赤芍、天花粉、苍术、黄柏、萆薢、泽泻、川牛膝各15g,乳香、没药、甘草各6g,穿山甲5g。
4.如权利要求1所述的治疗痛风性关节炎急性发作的中药制剂,其特征在于,所述的治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药优选配比为:当归、陈皮、浙贝母、皂角刺、山慈菇各6g,赤芍、天花粉、苍术、黄柏、萆薢、泽泻、川牛膝各12g,乳香、没药、甘草各4g,穿山甲3g。
5.如权利要求1所述的治疗痛风性关节炎急性发作的中药制剂,其特征在于,所述的治疗痛风性关节炎急性发作的中药制剂包括以下重量份数的原料药优选配比为:当归、陈皮、浙贝母、皂角刺、山慈菇各15g,赤芍、天花粉、苍术、黄柏、萆薢、泽泻、川牛膝各20g,乳香、没药、甘草、穿山甲各8g。
6.如权利要求1所述的治疗痛风性关节炎急性发作的中药制剂,其特征在于,所述的治疗痛风性关节炎急性发作的中药制剂采用水煎内服,每日1剂,煎2汁,分早、晚2次温服,7天为1个疗程。
7.如权利要求1所述的治疗痛风性关节炎急性发作的中药制剂,其特征在于,所述的治疗痛风性关节炎急性发作的中药制剂采用仙方活命饮加减。
8.如权利要求1所述的治疗痛风性关节炎急性发作的中药制剂,其特征在于,所述的治疗痛风性关节炎急性发作的中药制剂服药后注意事项:注重调理饮食,限制膏粱厚味,忌酒、咖啡、海鲜、动物内脏及酸性食物,饮食宜清淡;多饮水,增加尿酸浊毒的***;肥胖患者应减肥,保持适中体重。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610156745.6A CN105748927A (zh) | 2016-03-21 | 2016-03-21 | 一种治疗痛风性关节炎急性发作的中药制剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610156745.6A CN105748927A (zh) | 2016-03-21 | 2016-03-21 | 一种治疗痛风性关节炎急性发作的中药制剂 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105748927A true CN105748927A (zh) | 2016-07-13 |
Family
ID=56332146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610156745.6A Pending CN105748927A (zh) | 2016-03-21 | 2016-03-21 | 一种治疗痛风性关节炎急性发作的中药制剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105748927A (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106692787A (zh) * | 2017-02-28 | 2017-05-24 | 云南省中医医院 | 一种治疗急性痛风性关节炎的中药制剂及其制备方法 |
CN107517769A (zh) * | 2017-10-17 | 2017-12-29 | 四川华胜农业股份有限公司 | 一种猕猴桃育苗土壤配方及其制备方法 |
CN108992599A (zh) * | 2017-06-07 | 2018-12-14 | 徐定清 | 一种除湿痛风宁的中药丸剂 |
CN112057587A (zh) * | 2020-10-14 | 2020-12-11 | 深圳市福田区妇幼保健院 | 一种痛风用中药组合物及其制备方法、外用药和应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104689179A (zh) * | 2015-03-25 | 2015-06-10 | 张金钟 | 一种治疗痛风性关节炎急性发作的中药组合物 |
CN105343671A (zh) * | 2015-12-03 | 2016-02-24 | 陈利国 | 一种治疗膝关节滑膜炎药物 |
-
2016
- 2016-03-21 CN CN201610156745.6A patent/CN105748927A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104689179A (zh) * | 2015-03-25 | 2015-06-10 | 张金钟 | 一种治疗痛风性关节炎急性发作的中药组合物 |
CN105343671A (zh) * | 2015-12-03 | 2016-02-24 | 陈利国 | 一种治疗膝关节滑膜炎药物 |
Non-Patent Citations (2)
Title |
---|
华浩明等: "《中医骨伤科处方手册》", 30 November 2006, 科学技术文献出版社 * |
李含文等: "《实用软组织伤病学》", 30 September 2014, 人民体育出版社 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106692787A (zh) * | 2017-02-28 | 2017-05-24 | 云南省中医医院 | 一种治疗急性痛风性关节炎的中药制剂及其制备方法 |
CN108992599A (zh) * | 2017-06-07 | 2018-12-14 | 徐定清 | 一种除湿痛风宁的中药丸剂 |
CN107517769A (zh) * | 2017-10-17 | 2017-12-29 | 四川华胜农业股份有限公司 | 一种猕猴桃育苗土壤配方及其制备方法 |
CN112057587A (zh) * | 2020-10-14 | 2020-12-11 | 深圳市福田区妇幼保健院 | 一种痛风用中药组合物及其制备方法、外用药和应用 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104352991A (zh) | 一种治疗痛风的中药制剂及其制备方法 | |
CN105748927A (zh) | 一种治疗痛风性关节炎急性发作的中药制剂 | |
CN103860774A (zh) | 一种用于治疗痢疾和痔疮的中药组合物及制法 | |
CN104147499A (zh) | 一种治疗脾胃湿热型慢性胃炎的中药组合物及其制备方法 | |
CN109045229A (zh) | 治疗痛风性关节炎的中药组合物及其制备方法 | |
CN104815318A (zh) | 一种治疗痛风的中药制剂 | |
CN104587302A (zh) | 一种治疗急性阑尾炎的中药制剂 | |
CN106039109A (zh) | 防治寒湿阻络型的类风湿性关节炎的中药药酒 | |
CN105943705A (zh) | 一种治疗类风湿性关节炎的中药组合物及其制备方法 | |
CN103055111B (zh) | 一种治疗小儿疳积的中药组合物及其制备方法 | |
CN1248727C (zh) | 一种治疗痹症的胶囊及制作方法 | |
CN103386101B (zh) | 一种治疗非特异性膀胱炎的中药制剂及其制备方法 | |
CN104324280A (zh) | 一种治疗鼻咽癌的中药组合物及其制备方法 | |
CN104740405B (zh) | 一种治疗过敏性紫癜性肾损害的中药制剂及制备方法 | |
CN103585517A (zh) | 一种治疗肝炎、胆囊炎的药物组合物及其制备方法 | |
CN103705856B (zh) | 用于预防放化疗急性放射反应的中药组合物 | |
CN103520538B (zh) | 一种治疗糖尿病引致肾脏损害的药物组合物 | |
Jing et al. | Advances in the Application of State-target Dialectical Theory in the Treatment of Gouty Diseases | |
CN106236971A (zh) | 一种治疗慢性肾炎的中药组合物 | |
CN105727076A (zh) | 一种治疗慢性腹泻的中药组合物 | |
CN104306774A (zh) | 治疗流行性脑脊髓膜炎的中药制剂 | |
CN105106773B (zh) | 一种治疗痛风的中药组合物 | |
CN105434906A (zh) | 一种治疗口舌生疮的药物 | |
CN105055848A (zh) | 一种***的中药组合物 | |
CN104274708A (zh) | 一种用于治疗甲状腺功能亢进症的中药 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20160812 Address after: 450046 Henan city of Zhengzhou province Zheng Dong New District Yongping Road No. 100 (Henan province Luoyang city Chanhe Qiming Road No. 82) Applicant after: Luoyang Orthopedic-Traumatological Hospital Of Henan Province(Henan Provincial Orthopedic Hospital) Address before: 471002 Henan province Luoyang Qiming Chanhe Hui District Road No. 1 Applicant before: Chen Liguo |
|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160713 |
|
RJ01 | Rejection of invention patent application after publication |