CN105748826A - Traditional Chinese medicine composition for regulating spleen-stomach disharmony as well as oral liquid and preparation method thereof - Google Patents

Traditional Chinese medicine composition for regulating spleen-stomach disharmony as well as oral liquid and preparation method thereof Download PDF

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CN105748826A
CN105748826A CN201610218820.7A CN201610218820A CN105748826A CN 105748826 A CN105748826 A CN 105748826A CN 201610218820 A CN201610218820 A CN 201610218820A CN 105748826 A CN105748826 A CN 105748826A
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chinese medicine
medicine composition
oral liquid
traditional chinese
taste
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张德龙
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Beijing Yuxintang Biotechnology Co Ltd
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Beijing Yuxintang Biotechnology Co Ltd
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention provides a traditional Chinese medicine composition for regulating spleen-stomach disharmony. The traditional Chinese medicine composition is mainly prepared from Chinese yam, cassia seed, platycodon root, grosvener siraitia, white hyacinth bean, gordon euryale seed, flos buddlejae, herba cichorii, cherokee rose fruit and resin of sweetgum. Moreover, the invention also provides oral liquid of the traditional Chinese medicine composition and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition has a significant curative effect on patients with spleen-stomach disharmony; the preparation has very good stability and very high bioavailability; and the preparation method of the traditional Chinese medicine composition can effectively extract active ingredients of various raw medicinal materials, thereby more significantly improving the curative effect of regulating the spleen-stomach disharmony.

Description

A kind of regulate the Chinese medicine composition and oral liquid thereof and preparation method that taste become estranged
Technical field
The invention belongs to the field of Chinese medicines, regulate, particularly to a kind of, the Chinese medicine composition and oral liquid thereof and preparation method that taste become estranged.
Background technology
Along with the development of society, the deterioration of environment and the increasing of life stress, the phychology of people is unbalance, causes the physiological function senilism of human body.Taste are become estranged, high liver fire is contained is its key factor；Show as the symptoms such as habitual constipation is suffered from diarrhoea, complexion is turned white, coldness of the body with chills.
The compositions that disclosed in prior art, many adjustment taste are become estranged, for instance: CN103041282 discloses a kind of Chinese medicine treating asthenia of both the spleen and kidney and preparation method thereof, it is made up of Poria, Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata, Semen Euryales etc.；CN105055995 discloses a kind of Chinese medicine treating incoordination between the spleen and stomach, its by Flos Buddlejae, the moon Herba mesonae chinensis etc. form, etc.；The regulating effect that taste are become estranged by compositions majority disclosed in prior art is poor, and the content of the effective ingredient extracted is low, and the content of active substance is relatively high, causes that the cure rate of the Chinese medicine composition of prior art is low, affects its curative effect.
Summary of the invention
In order to solve above-mentioned technical problem, the present invention provides a kind of and regulates the Chinese medicine composition that taste are become estranged, and said composition has effect that significantly high adjustment taste are become estranged.
The concrete technical scheme of the present invention is as follows:
The present invention provides a kind of and regulates the Chinese medicine composition that taste are become estranged, and this Chinese medicine composition is mainly prepared from by the raw material of following weight portion:
The present invention is drawn by substantial amounts of test, adopts the Chinese medicine composition that the 10 taste crude drug such as Rhizoma Dioscoreae, Semen Cassiae, Radix Platycodonis are prepared from that adjustment taste are become estranged and has good effect, and effective percentage can reach more than 88%.
Preferably, the raw materials used raw material also including following weight portion of described Chinese medicine composition is prepared:
Black tea 10-15 Poria 5-10 Rhizoma Polygonati 40-50
Semen Coicis 5-15 Pericarpium Citri Reticulatae 15-20 Fructus Jujubae 5-10
Cordyceps militaris (L.) Link. 25-35 Radix Glycyrrhizae Preparata 12-20.
Not only significantly improve said composition by the Chinese medicine composition prepared after adding the 7 taste crude drug such as black tea and regulate effect that taste are become estranged, can effectively improve the body cards such as patient's high liver fire simultaneously.
Further improve, prepare the raw materials used raw material also including following weight portion of described Chinese medicine composition:
Herba Lycopodii 15-20 Herba Artemisiae Annuae 5-10 FRUCTUS TERMINALIAE IMMATURUS 20-30.
Not only significantly improve said composition by the Chinese medicine composition prepared after adding above-mentioned 3 taste crude drug and regulate effect that taste are become estranged, additionally play effect of blood fat reducing.
A kind of regulating the Chinese medicine composition that taste are become estranged, this Chinese medicine composition is mainly prepared from by the raw material of following weight portion:
Rhizoma Dioscoreae 20-30 Semen Cassiae 20-30 Radix Platycodonis 20-30
Fructus Momordicae 10-20 Semen Lablab Album 5-10 Semen Euryales 5-10
Black tea 10-15 Poria 5-10 Rhizoma Polygonati 40-50 Fructus Jujubae 5-10
Semen Coicis 5-15 Pericarpium Citri Reticulatae 15-20 Cordyceps militaris (L.) Link. 25-35
Radix Glycyrrhizae Preparata 12-20.
In order to carry and easy to use, Chinese medicine composition and adjuvant and water are made oral liquid by the present invention, and wherein, in described oral liquid, the ratio of weight and number of Chinese medicine composition, adjuvant and water is 1:0.5-1.5:3-5.
Further improving, it is 1-3 part Pullulan, 0.5-1 part isopropyl cetylate and 1.5-2.4 part sodium starch glycol that described adjuvant includes parts by weight.The present invention can significantly improve the dissolubility of Chinese medicine composition in oral liquid by adding above-mentioned 3 kinds of adjuvants, it is possible to promotes the absorption of this Chinese medicine composition.
Further improving, it is 0.3-0.5 part casein and 1-2 part microcrystalline Cellulose that described adjuvant also includes parts by weight.By adding the mixture of casein and microcrystalline Cellulose in adjuvant, it plays the effect improving stability of Oral.One-year age can be preserved under hot and humid environment, occur without muddy and deposited phenomenon.
Further improving, it is 0.4-0.7 part colloidal silica and 0.1-0.3 part xylitol that described adjuvant also includes parts by weight.Effect of anti-corrosive antibacterial can be played by adding the mixture of colloidal silica and xylitol.
The preparation method that another aspect of the present invention additionally provides Chinese medicine composition, the method comprises the steps:
1) Rhizoma Dioscoreae, Semen Cassiae, Radix Platycodonis, Fructus Momordicae, Semen Lablab Album and Semen Euryales are pulverized, it is inoculated in the culture tank containing profitable probliotics, add culture medium to cultivate, condition of culture is: initial ph value is 5.2-5.4, cultivation temperature 28-30 DEG C, shaking speed 200-220 rev/min, incubation time 3-5 days, it is thus achieved that culture fluid；Described culture medium is that 1-2 part peptone, 2-3 part gelatin, 5-10 part glutathion, 3-6 part tristerin, 1-2 part vitamin E, 2-5 part sodium chloride and 0.5-1 part potassium dihydrogen phosphate form by parts by weight；
2) by step 1) culture fluid that obtains is sonicated, and the time of supersound process is 5-10min, and ultrasonic power is 80-100kHz；
3) by the ferment in second time liquid petroleum ether extraction three times through supersound process, discard petroleum ether layer, collect water layer；
4) Flos Buddlejae, Herba Cichorii, Fructus Rosae Laevigatae and Resina Liquidambaris are joined in 5-7 times amount water, decoct 1-2h, decocts 3 times, merge decoction liquor, filtration, then by filtrate and step 3) water layer collected merges, and spray drying prepares Chinese medicine composition.
The content that the Chinese medicine composition prepared by above method is remarkably improved in compositions active component, makes the Chinese medicine composition of preparation have and regulates effect that taste are become estranged higher.
The present invention provides a kind of and regulates the Chinese medicine composition that taste are become estranged, and said composition has effect that well adjustment taste are become estranged, and simultaneously to adjusting the body cards such as high liver fire Sheng, reduces blood fat and is respectively provided with the curative effect arrived very much.
Detailed description of the invention
Embodiment 1
A kind of Chinese medicine composition, this Chinese medicine composition is grouped into by the one-tenth of following weight:
Embodiment 2
A kind of Chinese medicine composition, this Chinese medicine composition is grouped into by the one-tenth of following weight:
The preparation method of this Chinese medicine composition is as follows:
1) Rhizoma Dioscoreae, Semen Cassiae, Radix Platycodonis, Fructus Momordicae, Semen Lablab Album and Semen Euryales are pulverized, be inoculated in the culture tank containing profitable probliotics, add culture medium and cultivate, condition of culture is: initial ph value is 5.2, cultivation temperature 28 DEG C, shaking speed 200 revs/min, incubation time 3 days, it is thus achieved that culture fluid；Described culture medium is that 1 part of peptone, 2 parts of gelatin, 5 parts of glutathion, 3 parts of tristerins, 1 part of vitamin E, 2 parts of sodium chloride and 0.5 part of potassium dihydrogen phosphate form by parts by weight；
2) by step 1) culture fluid that obtains is sonicated, and the time of supersound process is 5min, and ultrasonic power is 80kHz；
3) by the ferment in second time liquid petroleum ether extraction three times through supersound process, discard petroleum ether layer, collect water layer；
4) Flos Buddlejae, Herba Cichorii, Fructus Rosae Laevigatae and Resina Liquidambaris are joined in 5 times amount water, decoct 2h, decocts 3 times, merge decoction liquor, filtration, then by filtrate and step 3) water layer collected merges, and spray drying prepares Chinese medicine composition.
Embodiment 3
A kind of Chinese medicine composition, this Chinese medicine composition is grouped into by the one-tenth of following weight:
Embodiment 4
A kind of Chinese medicine composition, this Chinese medicine composition is grouped into by the one-tenth of following weight:
The preparation method of this Chinese medicine composition is as follows:
1) Rhizoma Dioscoreae, Semen Cassiae, Radix Platycodonis, Fructus Momordicae, Semen Lablab Album, Semen Euryales, black tea, Poria, Rhizoma Polygonati, Semen Coicis, Pericarpium Citri Reticulatae, Fructus Jujubae, Cordyceps militaris (L.) Link. and Radix Glycyrrhizae Preparata are pulverized, it is inoculated in the culture tank containing profitable probliotics, add culture medium to cultivate, condition of culture is: initial ph value is 5.4, cultivation temperature 30 DEG C, shaking speed 220 revs/min, incubation time 5 days, it is thus achieved that culture fluid；Described culture medium is that 2 parts of peptones, 3 parts of gelatin, 10 parts of glutathion, 6 parts of tristerins, 2 parts of vitamin Es, 5 parts of sodium chloride and 1 part of potassium dihydrogen phosphate form by parts by weight；
2) by step 1) culture fluid that obtains is sonicated, and the time of supersound process is 10min, and ultrasonic power is 100kHz；
3) by the ferment in second time liquid petroleum ether extraction three times through supersound process, discard petroleum ether layer, collect water layer；
4) Flos Buddlejae, Herba Cichorii, Fructus Rosae Laevigatae and Resina Liquidambaris are joined in 7 times amount water, decoct 1h, decocts 3 times, merge decoction liquor, filtration, then by filtrate and step 3) water layer collected merges, and spray drying prepares Chinese medicine composition.
Embodiment 5
A kind of Chinese medicine composition, this Chinese medicine composition is grouped into by the one-tenth of following weight:
Embodiment 6
A kind of Chinese medicine composition, this Chinese medicine composition is grouped into by the one-tenth of following weight:
The preparation method of this Chinese medicine composition is as follows:
1) Rhizoma Dioscoreae, Semen Cassiae, Radix Platycodonis, Fructus Momordicae, Semen Lablab Album and Semen Euryales are pulverized, be inoculated in the culture tank containing profitable probliotics, add culture medium and cultivate, condition of culture is: initial ph value is 5.3, cultivation temperature 29 DEG C, shaking speed 210 revs/min, incubation time 4 days, it is thus achieved that culture fluid；Described culture medium is that 1.5 parts of peptones, 2.5 parts of gelatin, 7 parts of glutathion, 5 parts of tristerins, 1.5 parts of vitamin Es, 3 parts of sodium chloride and 0.7 part of potassium dihydrogen phosphate form by parts by weight；
2) by step 1) culture fluid that obtains is sonicated, and the time of supersound process is 7min, and ultrasonic power is 90kHz；
3) by the ferment in second time liquid petroleum ether extraction three times through supersound process, discard petroleum ether layer, collect water layer；
4) Flos Buddlejae, Herba Cichorii, Fructus Rosae Laevigatae, Resina Liquidambaris, Herba Lycopodii, Herba Artemisiae Annuae and FRUCTUS TERMINALIAE IMMATURUS are joined in 6 times amount water, decoct 2h, decoct 3 times, merge decoction liquor, filtering, then by filtrate and step 3) water layer collected merges, and spray drying prepares Chinese medicine composition.
Embodiment 7
A kind of Chinese medicine composition, this Chinese medicine composition is grouped into by the one-tenth of following weight:
Embodiment 8
A kind of Chinese medicine composition, this Chinese medicine composition is grouped into by the one-tenth of following weight:
The preparation method of this Chinese medicine composition is as follows:
1) Rhizoma Dioscoreae, Semen Cassiae, Radix Platycodonis, Fructus Momordicae, Semen Lablab Album, Semen Euryales, black tea, Poria, Rhizoma Polygonati, Semen Coicis, Pericarpium Citri Reticulatae, Fructus Jujubae, Cordyceps militaris (L.) Link. and Radix Glycyrrhizae Preparata are pulverized, it is inoculated in the culture tank containing profitable probliotics, add culture medium to cultivate, condition of culture is: initial ph value is 5.4, cultivation temperature 30 DEG C, shaking speed 220 revs/min, incubation time 5 days, it is thus achieved that culture fluid；Described culture medium is that 2 parts of peptones, 3 parts of gelatin, 10 parts of glutathion, 6 parts of tristerins, 2 parts of vitamin Es, 5 parts of sodium chloride and 1 part of potassium dihydrogen phosphate form by parts by weight；
2) by step 1) culture fluid that obtains is sonicated, and the time of supersound process is 10min, and ultrasonic power is 100kHz；
3) by the ferment in second time liquid petroleum ether extraction three times through supersound process, discarding petroleum ether layer, collect water layer, filter, spray drying prepares Chinese medicine composition.
Embodiment 9 oral liquid
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Embodiment 10 oral liquid
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Embodiment 11 oral liquid
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Embodiment 12 oral liquid
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Embodiment 13 oral liquid
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Embodiment 14
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Embodiment 15 oral liquid
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Reference examples 1 oral liquid
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Reference examples 2 oral liquid
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Reference examples 3 oral liquid
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Reference examples 4 oral liquid
The consumption of each composition of oral liquid is:
Prepared by conventional method.
Reference examples 5
A kind of Chinese medicine composition, this Chinese medicine composition is grouped into by the one-tenth of following weight:
Rhizoma Dioscoreae 20g Semen Cassiae 20g Radix Platycodonis 20g
Fructus Momordicae 10g Semen Lablab Album 5g Semen Euryales 5g.
Reference examples 6
A kind of Chinese medicine composition, this Chinese medicine composition is grouped into by the one-tenth of following weight:
Test example 1 vitro release determination test
The drug release rate detection of oral liquid: check with reference to 2010 editions version " Chinese Pharmacopoeia " annex XIXD vitro drug release degree.
Take the oral liquid of above example 9, reference examples 1 and reference examples 2 respectively, put in medicament dissolution instrument, separately sampled in 1h, 2h, 4h, 6h, 12h, 16h, 24h, detect dissolution percentage rate by high performance liquid chromatography, and calculating the cumulative release percentage rate of medicine, result is in Table 1.
Dissolution (%) result of the test of table 1 inventive samples
The whole dissolution of the oral liquid of embodiment 9 effective ingredient in 12h as can be seen from the table, and the oral liquid of comparative examples 1-2 still has fractions not have dissolution in 24h, and then affect its curative effect.
Test example 2 stability test
1. accelerated test
The oral liquid of Example 12, comparative examples 3 and comparative examples 4, all at temperature 40 DEG C ± 2 DEG C, place 6 months when relative humidity is 75% ± 5%, testing, 1 month period, 2 months, 3 months, 6 the end of month are separately sampled once, the detection character of oral liquid, color and luster, abnormal smells from the patient, main constituent content (labelled amount %), moisture, it was found that the indices of embodiment 12 has no significant change；And the color of the oral liquid of comparative examples 3 and comparative examples 4 substantially deepens, and precipitation occurs.
2. long term test
The oral liquid of Example 12, comparative examples 3 and comparison 4, all at temperature 25 DEG C ± 2 DEG C, place 12 months when relative humidity is 60% ± 10%, testing, 0 month period, 3 months, 6 months, 9 months, 12 the end of month are separately sampled once, the detection character of oral liquid, color and luster, main constituent content (labelled amount %), moisture, it was found that the indices of embodiment 10 has no significant change；And the color of the oral liquid of comparative examples 3 and comparative examples 4 substantially deepens, the content of main component is decreased obviously, and muddy and precipitation occurs.
It can be seen that the mixture of casein and microcrystalline Cellulose is remarkably improved the stability of oral liquid from accelerated test and long term test, lacking one of them composition, or change one of them composition, the stability of oral liquid declines.
Test example 3 effectiveness comparison
One, the effect that taste are become estranged
(1) tcm diagnosis standard
Main symptom: distension and fullness in the abdomen, unsuitable diet, feel sick, dark tongue quality, yellow fur；
(2) Chinese medical discrimination
Pattern of syndrome: dysfunction of the spleen in transportation, incoordination between the spleen and stomach；
(3) Western medicine diagnose standard
The intestines and stomach dysbacteriosis, gastric motility declines, and central functions is lacked of proper care, cause feel sick, minimizings of abdominal distention, diet, epigastric discomfort etc. are demonstrate,proved；
(4) test crowd
175 examples meet taste and become estranged the experimenter of symptom, and the age is all between 25-60 year.
(5) packet
The experimenter that become estranged by 175 example taste is randomly divided into 1 group of 25 people of test, tests 2 group of 25 people, tests 3 group of 25 people, test 4 group of 25 people, tests 5 group of 25 people, compares 1 group of 25 people and 2 group of 25 people of comparison；Test 1 group and use the embodiment of the present invention, the Chinese medicine composition described in 7；Test 2 groups of Chinese medicine compositions using the embodiment of the present invention 8；Test 3 groups of Chinese medicine compositions using the embodiment of the present invention 1；Test 4 groups of Chinese medicine compositions using the embodiment of the present invention 2；Test 5 groups of Chinese medicine compositions using the embodiment of the present invention 3；Compare 1 group of Chinese medicine composition using reference examples 5；Compare 2 groups of Chinese medicine compositions using reference examples 6；6 groups all use 6 months.
(6) functional evaluation
1. curative effect observation
According to the guideline of clinical investigations that Chinese traditional treatment taste are become estranged, specially formulate the card classification of symptom body and curative effect judging standard
A degree is standards of grading
Violent abdominal distention 3 points of moderate abdominal distention of 4 points of severe abdominal distention 2 points
Normal 0 point of slight abdominal distention 1 point
B is with fed state for standards of grading
Do not take food completely 4 points and only enter seldom food 3 points and eat less food person 2 points
Trencherman 0 point is normally entered than normal feed less slightly person 1 point
Relatively 4 points of temper discomforts of severe one are lighter 3 points for temper discomfort
Spleen district without uncomfortable, dizzy, feel sick 2 points nearly dizzy 1 point normal 0 point
2. Outcome measure
Recovery from illness: clinical symptoms, body card integration reduces >=95%；
Effective: clinical symptoms, body card integration reduces 70-90%；
Effective: clinical symptoms, body card integration reduces 50-70%；
Invalid: clinical symptoms, body card integration reduces≤50%；
(7) statistical analysis
Test data adopt spss10.0 software carry out statistical analysis, measurement data withComparing employing t inspection between group, in group, different time points compare employing one factor analysis of variance, and P < 0.05 is variant.
(8) result
The result of 7 groups of subject immune's power changes is in Table 2；
27 groups of compositionss of table regulate effectiveness comparison that taste become estranged ()
Test 1-5 group is compared with compareing 1 group and comparison 2 groups, and the adjustment curative effect that taste are become estranged there are differences (P < 0.05).
(9) conclusion
After using the Chinese medicine composition of embodiment 1-3 and embodiment 7-8, every body card that patient's taste are become estranged can be significantly improved；But test 2-5 group regulating effect is apparently higher than testing 1 group, there is significant difference with matched group.
Two, the therapeutic effect to high liver fire
1. physical data:
Body is demonstrate,proved: often feel fatigue, conjunctival congestion, liver-fire weight, irritability；Age is between 25-50 year；
2. packet and administration: 75 example high liver fire patients are randomly divided into 3 groups, often organize 25 people, test 1 group: use the Chinese medicine composition described in the embodiment of the present invention 1；Test 2 groups of Chinese medicine compositions using the embodiment of the present invention 3；Compare 1 group of Chinese medicine composition using CN105381200 disclosed treatment hyperactivity of hesrt-fire and liver-fire；It within 4 weeks, it is a course for the treatment of；
3. observation index: observe the body card before and after treatment；
4. curative effect determinate standard:
Cure: clinical symptoms body card disappears；
Effective: clinical symptoms body card is basic to disappear；
Effective: clinical symptoms body is demonstrate,proved big portion and disappeared；
Invalid: unchanged；
5. therapeutic outcome
Test group and matched group to the therapeutic effect of high liver fire respectively in Table 3.
Each group of therapeutic effect to high liver fire of table 3 compares
Test 2 groups with test 1 group, compare 1 group of curative effect to high liver fire and there are differences (P < 0.05).
6. conclusion: it is 100% to the effective percentage of high liver fire that the present invention tests 2 groups of compositionss provided, and curative effect is superior to matched group；In verifying its curative effect process, do not find any untoward reaction and abnormal phenomena.
Three, the therapeutic effect to hyperlipidemia
1. physical data: for investigating the clinical efficacy of the present composition further, selects 75 example hyperlipemic patients that the curative effect of oral liquid of the present invention is carried out clinical observation；This 75 example MethodsThe cases enrolled all meets the diagnostic criteria of hyperlipidemia；Cholesterol >=15.72mmol/L, triglyceride >=2.26mmol/L confirmation is hyperlipemic patients；Age is between 25-50 year；
2. packet and administration: 75 example hyperlipemic patients are randomly divided into 3 groups, often organize 25 people, test 1 group: use the Chinese medicine composition described in the embodiment of the present invention 1；Test 2 groups of Chinese medicine compositions using the embodiment of the present invention 5；Compare 1 group and use Xuezhikang；It within 4 weeks, it is a course for the treatment of；
3. observation index: observe the change of the amount of cholesterol and triglyceride before and after treatment；
4. curative effect determinate standard: according to country " clinical diagnosis is according to curing improvement standard "
Cure: clinical symptoms body card disappears, and the cholesterol of hyperlipemic patients and the recovery of triglyceride are normal；
Effective: clinical symptoms body card is basic to disappear, and the cholesterol of hyperlipemic patients declines more than 20%, or the amount of triglyceride declines 40%；
Effective: clinical symptoms body is demonstrate,proved big portion and disappeared, and the cholesterol of hyperlipemic patients declines at 10%-20%, or the amount of triglyceride drops to 20%-40%；
Invalid: the cholesterol of hyperlipemic patients and the amount of triglyceride are unchanged；
5. therapeutic outcome
Test group and matched group to the therapeutic effect of hyperlipidemia respectively in Table 4.
Each group of therapeutic effect to hyperlipidemia of table 4 compares
Test 2 groups with test 1 group, compare 1 group of curative effect to hyperlipidemia and there are differences (P < 0.05).
6. conclusion: it is 96.0% to the effective percentage of hyperlipidemia that the present invention tests 2 groups of compositionss provided, and curative effect is superior to matched group；In verifying its curative effect process, do not find any untoward reaction and abnormal phenomena.

Claims (10)

1. one kind regulates the Chinese medicine composition that taste are become estranged, it is characterised in that described Chinese medicine composition is mainly prepared from by the raw material of following weight portion:
2. the Chinese medicine composition that adjustment taste as claimed in claim 1 are become estranged, it is characterised in that prepare the raw materials used raw material also including following weight portion of described Chinese medicine composition:
Black tea 10-15 Poria 5-10 Rhizoma Polygonati 40-50
Semen Coicis 5-15 Pericarpium Citri Reticulatae 15-20 Fructus Jujubae 5-10
Cordyceps militaris (L.) Link. 25-35 Radix Glycyrrhizae Preparata 12-20.
3. the Chinese medicine composition that adjustment taste as claimed in claim 1 are become estranged, it is characterised in that prepare the raw materials used raw material also including following weight portion of described Chinese medicine composition:
Herba Lycopodii 15-25 Herba Artemisiae Annuae 5-10 FRUCTUS TERMINALIAE IMMATURUS 20-30.
4. one kind regulates the Chinese medicine composition that taste are become estranged, it is characterised in that described Chinese medicine composition is mainly prepared from by the raw material of following weight portion:
5. an oral liquid, the arbitrary described adjustment taste of claim 1-4 Chinese medicine composition, adjuvant and the water become estranged form, it is characterised in that the ratio of weight and number of described Chinese medicine composition, adjuvant and water is 1:0.5-1.5:3-5.
6. oral liquid as claimed in claim 5, it is characterised in that it is 1-3 part Pullulan, 0.5-1 part isopropyl cetylate and 1.5-2.4 part sodium starch glycol that described adjuvant includes parts by weight.
7. oral liquid as claimed in claim 6, it is characterised in that it is 0.3-0.5 part casein and 1-2 part microcrystalline Cellulose that described adjuvant also includes parts by weight.
8. oral liquid as claimed in claim 7, it is characterised in that it is 0.4-0.7 part colloidal silica and 0.1-0.3 part xylitol that described adjuvant also includes parts by weight.
9. the preparation method of the Chinese medicine composition described in a claim 1, it is characterised in that described method comprises the steps:
1) Rhizoma Dioscoreae, Semen Cassiae, Radix Platycodonis, Fructus Momordicae, Semen Lablab Album and Semen Euryales are pulverized, it is inoculated in the culture tank containing profitable probliotics, add culture medium to cultivate, condition of culture is: initial ph value is 5.2-5.4, cultivation temperature 28-30 DEG C, shaking speed 200-220 rev/min, incubation time 3-5 days, it is thus achieved that culture fluid；Described culture medium is that 1-2 part peptone, 2-3 part gelatin, 5-10 part glutathion, 3-6 part tristerin, 1-2 part vitamin E, 2-5 part sodium chloride and 0.5-1 part potassium dihydrogen phosphate form by parts by weight；
2) by step 1) culture fluid that obtains is sonicated, and the time of supersound process is 5-10min, and ultrasonic power is 80-100kHz；
3) by the ferment in second time liquid petroleum ether extraction three times through supersound process, discard petroleum ether layer, collect water layer；
4) Flos Buddlejae, Herba Cichorii, Fructus Rosae Laevigatae and Resina Liquidambaris are joined in 5-7 times amount water, decoct 1-2h, decocts 3 times, merge decoction liquor, filtration, then by filtrate and step 3) water layer collected merges, and spray drying prepares Chinese medicine composition.
10. the arbitrary described Chinese medicine composition of claim 1-4 preparation regulate taste become estranged, application in the medicine of high liver fire, reduction blood fat.
CN201610218820.7A 2016-04-08 2016-04-08 Traditional Chinese medicine composition for regulating spleen-stomach disharmony as well as oral liquid and preparation method thereof Pending CN105748826A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062229A (en) * 2007-05-19 2007-10-31 周海萍 Nutritional medicine for promoting digestion
CN104474202A (en) * 2014-12-04 2015-04-01 邹士东 Pharmaceutical composition for treating anorexia
CN105056092A (en) * 2015-08-21 2015-11-18 北京汉典制药有限公司 Preparation method of ginseng, poria cocos and white atractylodes rhizome granules and prepared ginseng, poria cocos and white atractylodes rhizome granules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062229A (en) * 2007-05-19 2007-10-31 周海萍 Nutritional medicine for promoting digestion
CN104474202A (en) * 2014-12-04 2015-04-01 邹士东 Pharmaceutical composition for treating anorexia
CN105056092A (en) * 2015-08-21 2015-11-18 北京汉典制药有限公司 Preparation method of ginseng, poria cocos and white atractylodes rhizome granules and prepared ginseng, poria cocos and white atractylodes rhizome granules

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