CN105732619B - A kind of synthetic method of 5,6,7,8 tetrahydropyridines simultaneously [2,3 d] pyrimidines - Google Patents

A kind of synthetic method of 5,6,7,8 tetrahydropyridines simultaneously [2,3 d] pyrimidines Download PDF

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CN105732619B
CN105732619B CN201610077863.8A CN201610077863A CN105732619B CN 105732619 B CN105732619 B CN 105732619B CN 201610077863 A CN201610077863 A CN 201610077863A CN 105732619 B CN105732619 B CN 105732619B
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pyrimidines
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tetrahydropyridines simultaneously
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CN105732619A (en
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张珉
熊彪
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South China University of Technology SCUT
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

The invention belongs to medication chemistry synthesis technical field, a kind of synthetic method of 5,6,7,8 tetrahydropyridines simultaneously [2,3 d] pyrimidines is disclosed.The synthetic method is：In the reactor, the compound 2, metallic catalyst, part and solvent of compound 1, formula (2) structure with formula (1) structure are added, alkali is added for accelerator, inert gas is passed through, stirring reaction 1~48 hour at 40~150 DEG C, reaction is cooled to room temperature after terminating, dilute reaction solution, filtering, removes solvent under reduced pressure and obtains crude product, and crude by column chromatography purification obtains 5,6,7,8 tetrahydropyridines simultaneously [2,3 d] pyrimidines.The present invention is the tetrahydropyridine of raw material one-step synthesis 5,6,7,8 simultaneously [2,3 d] pyrimidines with alcohol and nitrile, have the advantages that synthesis step simply, it is synthetic method safe operation, advantages of nontoxic raw materials, cheap and good to functional group adaptability.

Description

A kind of synthetic method of 5,6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines
Technical field
The invention belongs to medication chemistry synthesis technical field, and in particular to a kind of 5,6,7,8- tetrahydropyridines are simultaneously [2,3-d] The synthetic method of pyrimidines.
Background technology
Pyrido-pyrimidines are the nitrogen heterocyclics that a class has notable biological activity, in medicine and agricultural chemicals neck Domain extensive application.Numerous pharmaceutical researches show that such compound can be used for sterilization, anti-inflammatory, anti-ventilation, anti-mistake Quick, antitumor, resisting cardiovascular disease, plant reconcile in terms of agrochemical.Wherein, pyrido-pyrimidines are good two Hydrogen folic acid reductase inhibitor, the therapeutic effect to tumour, leukaemia and some neurogenic diseases is especially protruded.In recent years, portion Differentiation compound commercialization, such as sedative (pirenperone), anti-allergic agent (barmastine) and anti-ulcer medicament Deng.Therefore, the synthesis of Pyridopyrimidine is widely paid close attention to always.
The synthetic method of traditional 5,6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines is with 2- amino -3- amidines Yl pyridines, propionic andydride are raw material, and target compound is built by multistep intermolecular condensation, dehydration.However, the method is walked Rapid cumbersome, yield relatively low (B.Vercek, M.J.Org.Chem.1979,44,1695-1699).Additionally, also have utilizing Ring pentanamide and formamide in the presence of POCl3, product are obtained by dehydrating condensation as raw material.Wherein, trichlorine oxygen Phosphorus has tear-gas, high poison and severe corrosive, easily causes environmental pollution, the serious production for threatening people and living safety, so It is extremely restricted in commercial Application (G.Jones, S.P.Stanforth, Organic Reaction, 2000,56).
In recent years, the method on synthesis 5,6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines is also reported successively Road, mainly has：(1) multistep reaction of 2- aminomethyls -3- (2- nitrobenzophenones)-methyl acrylates and formamide, wherein same profit Use POCl3 and carried out cyclization and obtain target product.(S.Nag,S.Madapa,S.Batra,Synthesis,2008,1, 101-109)；(2) condensation reaction of 2- piperidones -3- Ethyl formates and guanidine prepares tetrahydropyridine hepyramine amine, in potassium carbonate In the presence of, single step reaction reached moderate yield (K.Radhakrishnan, N.Sharma, L.M.Kundu, RSC Adv., 2014,4,15087-15090).But, above technology is still present synthesis step complexity, condition and is difficult to control to be limited with substrate Shortcoming.
The content of the invention
In order to solve the shortcoming and defect part of above prior art, primary and foremost purpose of the invention is to provide a kind of 5,6, The synthetic method of 7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines.
The object of the invention is achieved through the following technical solutions：
A kind of synthetic method of 5,6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines, comprises the following steps：
In the reactor, compound 1, compound 2, metallic catalyst, part and solvent are added, alkali is added to promote Agent, is passed through inert gas, stirring reaction 1~48 hour at 40~150 DEG C, and reaction is cooled to room temperature, diluting reaction after terminating Liquid, filtering removes solvent under reduced pressure and obtains crude product, and crude by column chromatography purification obtains 5,6,7,8- tetrahydropyridines simultaneously [2,3-d] Pyrimidines；
Described compound 1 refers to the compound with structure shown in formula (1)；Described compound 2 refers to formula (2) The aromatic nitriles or alkyl nitrile of structure；
In formula, X and Y is carbon atom or nitrogen-atoms；R1And R2It is methyl or hydrogen；R3It is butyl, cyclopropyl, phenyl, 2- thiophene Base, 3- fluorophenyls, 3- cyanophenyls, 4- aminomethyl phenyls, 4- methoxyphenyls, 4- methyl mercaptos phenyl, 4- chlorphenyls, 4- bromobenzenes Base, 4- cyanophenyls, 4-N, N- 3,5-dimethylphenyls or 4- trifluoromethyls.
Partial reaction equation involved by above-mentioned synthetic method is as follows：
Described compound 1 is preferably 2- amino -3- hydroxymethylpyridines, 2- methylol -3- aminopyridines, 6- methyl -2- Amino -3- hydroxymethylpyridines or 1- (PA) ethanol.
Preferred schlenk pipes (history Ranque tube) of described reactor；Described inert gas is nitrogen or argon gas.
The compound 1 is 1 with the mol ratio of compound 2:(1~20)；It is preferred that 1:1.5.
Described metallic catalyst is pungent copper acetate, copper sulphate, iron chloride, palladium, bis-triphenylphosphipalladium palladium dichloride, ring Double (the 4- isopropyl methyls phenyl) rutheniums of diene iridium chloride, iridous chloride, the ruthenium of ten dicarbapentaborane three, dichloro and bi triphenyl phosphine -1H- indenes One or more mixing in ruthenic chloride.
Described part is triphenylphosphine, Phen, double (diphenylphosphine) butane, 2- phenylpyridines and 4,5- couples of 1,4- One or more mixing in diphenylphosphine -9,9- dimethyl xanthene (Xantphos).
Described solvent is acetonitrile, tetrahydrofuran, N,N-dimethylformamide, dimethyl sulfoxide (DMSO), toluene, methyl alcohol, uncle penta One or more mixing in alcohol and water.
The alkali is sodium carbonate, potassium carbonate, cesium carbonate, sodium methoxide, potassium tert-butoxide, sodium tert-butoxide, tert-butyl alcohol lithium, tetramethyl One or more mixing in ethylenediamine and triethylamine；The addition of alkali is (0.5~5) with the mol ratio of compound 1: 1；It is preferred that 0.5:1.
Described column chromatography purification eluent used is petroleum ether:The volume ratio of ethyl acetate is (0.5~50):1 Mixed solvent.
Synthetic method of the invention has the following advantages that and beneficial effect：
The present invention is the tetrahydropyridine of raw material one-step synthesis 5,6,7,8- simultaneously [2,3-d] pyrimidines with alcohol and nitrile, is had There is synthesis step simple, synthetic method safe operation, advantages of nontoxic raw materials, cheap and good to functional group adaptability.
Brief description of the drawings
Fig. 1 and Fig. 2 are respectively the hydrogen spectrogram and carbon spectrogram of the products therefrom of embodiment 1；
Fig. 3 and Fig. 4 are respectively the hydrogen spectrogram and carbon spectrogram of the products therefrom of embodiment 2；
Fig. 5 and Fig. 6 are respectively the hydrogen spectrogram and carbon spectrogram of the products therefrom of embodiment 3；
Fig. 7 and Fig. 8 are respectively the hydrogen spectrogram and carbon spectrogram of the products therefrom of embodiment 4；
Fig. 9 and Figure 10 are respectively the hydrogen spectrogram and carbon spectrogram of the products therefrom of embodiment 5；
Figure 11 and Figure 12 are respectively the hydrogen spectrogram and carbon spectrogram of the products therefrom of embodiment 6；
Figure 13 and Figure 14 are respectively the hydrogen spectrogram and carbon spectrogram of the products therefrom of embodiment 7；
Figure 15 and Figure 16 are respectively the hydrogen spectrogram and carbon spectrogram of the products therefrom of embodiment 8；
Figure 17 and Figure 18 are respectively the hydrogen spectrogram and carbon spectrogram of the products therefrom of embodiment 9.
Specific embodiment
With reference to embodiment, the present invention is described in further detail, but embodiments of the present invention not limited to this.
Embodiment 1
Added in schlenk pipes 0.5 mM of 2- amino -3- hydroxymethylpyridine, 0.75 mM of 4- methyl benzonitrile, 0.25 mM of potassium tert-butoxide, 0.005 mM of ten ruthenium of dicarbapentaborane three, 0.015 mM of double diphenylphosphine -9 of 4,5-, 9- diformazans Base xanthene, 0.3 ml methanol and 1.2 milliliters of tert-pentyl alcohols, are filled with N2Protection, after 130 DEG C of stirring reactions 8 hours, stop plus Heat and stirring, are cooled to room temperature, dilute reaction solution, filtering, vacuum rotary steam removal solvent, then by column chromatographic isolation and purification, obtain To target product, column chromatography eluent used is that volume ratio is 8:1 petroleum ether:Ethyl acetate mixed solvent, yield 91%.
Respectively as depicted in figs. 1 and 2, structural characterization data are as follows for the hydrogen spectrogram and carbon spectrogram of products therefrom：
1H NMR(400MHz,CDCl3):δ=8.07 (d, J=8.0Hz, 2H), 7.94 (s, 1H), 7.15 (d, J= 8.0Hz, 2H), 5.99 (brs, 1H), 3.23 (s, 2H), 2.59 (t, J=5.6Hz, 2H), 2.30 (s, 3H), 1.78-1.82 (m, 2H)。
13C NMR(100MHz,CDCl3):δ=162.72,160.38,153.15,139.82,135.70,129.02, 127.70,110.85,41.08,23.51,21.39,20.62。
IR(KBr):3227,3080,2927,2842,1604,1552,1424,1372,1326,1083,1050,1006, 788,705cm-1。
MS(EI,m/z):225[M]+。
HRMS(ESI):Calcd.for C14H15N3[M+H]+:226.1339；found:226.1339.
The structure for inferring products therefrom according to data above is shown below：
Embodiment 2
0.5 mM of 2- amino -3- hydroxymethylpyridines, 0.75 mM of 4- methoxybenzene first are added in schlenk pipes Nitrile, 0.25 mM of potassium tert-butoxide, 0.005 mM of ten ruthenium of dicarbapentaborane three, 0.015 mM of double diphenylphosphine -9 of 4,5-, 9- Dimethyl xanthene, 0.3 ml methanol and 1.2 milliliters of tert-pentyl alcohols, are filled with N2Protection, after 130 DEG C of stirring reactions 9 hours, stops Only heat and stir, be cooled to room temperature, dilute reaction solution, filtering, vacuum rotary steam removes solvent, then pure by column chromatography for separation Change, obtain target product, column chromatography eluent used is that volume ratio is 7:1 petroleum ether:Ethyl acetate mixed solvent, yield 82%.
Respectively as shown in Figure 3 and Figure 4, structural characterization data are as follows for the hydrogen spectrogram and carbon spectrogram of products therefrom：
1H NMR(400MHz,CDCl3):δ=8.24 (d, J=8.0Hz, 2H), 7.99 (s, 1H), 6.94 (d, J= 7.6Hz,2H),6.14(brs,1H),3.83(s,3H),3.29(s,2H),2.65(s,2H),1.87(s,2H)。
13C NMR(101MHz,CDCl3):δ=162.38,161.10,160.35,153.22,131.25,129.24, 113.56,110.44,55.30,41.06,23.50,20.69。
IR(KBr):3217,3002,2927,2857,1604,1549,1429,1320,1244,1165,1103,1030, 837,790,677cm-1。
MS(EI,m/z):241[M]+。
HRMS(ESI):Calcd.for C14H15N3O[M+H]+:242.1288；found:242.1284.
Infer that products therefrom obtains structure and is shown below according to data above：
Embodiment 3
0.5 mM of 2- amino -3- hydroxymethylpyridines, 0.75 mM of 4- methylthio phenyl first are added in schlenk pipes Nitrile, 0.25 mM of potassium tert-butoxide, 0.005 mM of ten ruthenium of dicarbapentaborane three, 0.015 mM of double diphenylphosphine -9 of 4,5-, 9- Dimethyl xanthene, 0.3 ml methanol and 1.2 milliliters of tert-pentyl alcohols, are filled with N2Protection, after 130 DEG C of stirring reactions 8 hours, stops Only heat and stir, be cooled to room temperature, dilute reaction solution, filtering, vacuum rotary steam removes solvent, then pure by column chromatography for separation Change, obtain target product, column chromatography eluent used is that volume ratio is 8:1 petroleum ether:Ethyl acetate mixed solvent, yield 75%.
Respectively as shown in Figure 5 and Figure 6, structural characterization data are as follows for the hydrogen spectrogram and carbon spectrogram of products therefrom：
1H NMR(400MHz,CDCl3):δ=8.14 (d, J=8.4Hz, 2H), 7.94 (s, 1H), 7.21 (d, J=8.4Hz 2H), 5.42 (brs, 1H), 3.35 (s, 2H), 2.62 (t, J=6.0Hz, 2H), 2.44 (s, 3H), 1.85-1.89 (m, 2H).
13C NMR(101MHz,CDCl3):δ=162.17,160.27,153.26,140.69,135.20,128.08, 125.80,110.94,41.15,23.51,20.69,15.45。
IR(KBr):3234,3070,2942,1600,1545,1425,1325,1222,1183,1091,1007,834, 786cm-1。
MS(EI,m/z):257[M]+。
HRMS(ESI):Calcd.for C14H15N3S[M+H]+:258.1059；found:258.1055.
Infer that products therefrom obtains structure and is shown below according to data above：
Embodiment 4
0.5 mM of 2- amino -3- hydroxymethylpyridines, 0.75 mM of 4- trifluoromethylbenzene are added in schlenk pipes Formonitrile HCN, 0.25 mM of potassium tert-butoxide, 0.005 mM of ten ruthenium of dicarbapentaborane three, 0.015 mM of double diphenylphosphine -9 of 4,5-, 9- dimethyl xanthene, 0.3 ml methanol and 1.2 milliliters of tert-pentyl alcohols, are filled with N2Protection, after 130 DEG C of stirring reactions 12 hours, Stop heating and stir, be cooled to room temperature, dilute reaction solution, filtering, vacuum rotary steam removes solvent, then pure by column chromatography for separation Change, obtain target product, column chromatography eluent used is that volume ratio is 6:1 petroleum ether:Ethyl acetate mixed solvent, yield 72%.
Respectively as shown in Figure 7 and Figure 8, structural characterization data are as follows for the hydrogen spectrogram and carbon spectrogram of products therefrom：
1H NMR(400MHz,CDCl3):δ=8.33 (d, J=8.0Hz, 2H), 7.99 (s, 1H), 7.60 (d, J= 7.6Hz, 2H), 5.37 (brs, 1H), 3.40 (s, 2H), 2.84 (t, J=5.6Hz, 2H), 1.90 (s, 2H).
13C NMR(101MHz,CDCl3):δ=161.24,160.33,153.29,141.74,127.98,125.64, 125.17(q,JC-F=3.7Hz), 111.88,41.17,23.49,20.54.
IR(KBr):3251,3061,2942,2853,1605,1549,1430,1327,1162,1118,1069,855, 790cm-1。
MS(EI,m/z):279[M]+。
HRMS(ESI):Calcd.for C14H12N3F3[M+H]+:280.1056；found:280.1050.
Infer that products therefrom obtains structure and is shown below according to data above：
Embodiment 5
Added in schlenk pipes 0.5 mM of 2- amino -3- hydroxymethylpyridine, 0.75 mM of 2- cyano-thiophene, 0.5 mM of potassium tert-butoxide, 0.005 mM of ten ruthenium of dicarbapentaborane three, 0.015 mM of double diphenylphosphine -9 of 4,5-, 9- diformazans Base xanthene, 0.3 ml methanol and 1.2 milliliters of tert-pentyl alcohols, are filled with N2Protection, after 130 DEG C of stirring reactions 8 hours, stop plus Heat and stirring, are cooled to room temperature, dilute reaction solution, filtering, vacuum rotary steam removal solvent, then by column chromatographic isolation and purification, obtain To target product, column chromatography eluent used is that volume ratio is 6:1 petroleum ether:Ethyl acetate mixed solvent, yield 81%.
Respectively as shown in Figure 9 and Figure 10, structural characterization data are as follows for the hydrogen spectrogram and carbon spectrogram of products therefrom：
1H NMR(400MHz,CDCl3):δ=7.93 (s, 1H), 7.83 (s, 1H), 7.34-7.40 (m, 1H), 7.05- 7.10(m,1H),5.99(brs,1H),3.35(s,2H),2.64(s,2H),1.88(s,2H)。
13C NMR(101MHz,CDCl3):δ=160.11,159.14,153.07,144.26,128.17,127.83, 127.31,110.88,41.11,23.57,20.59。
IR(KBr):3251,2928,2852,1606,1538,1441,1407,1353,1278,1195,1061,1005, 846,787,692cm-1。
MS(EI,m/z):217[M]+。
HRMS(ESI):Calcd.for C11H11N3S[M+H]+:218.0746；found:218.0744.
Infer that products therefrom obtains structure and is shown below according to data above：
Embodiment 6
0.5 mM of 2- amino -3- hydroxymethylpyridines, 0.75 mM of cyclopropanecarbonitrile, 0.25 are added in schlenk pipes MM potassium tert-butoxide, 0.005 mM of ten ruthenium of dicarbapentaborane three, 0.015 mM of double diphenylphosphine -9 of 4,5-, 9- dimethyl oxygens Miscellaneous anthracene, 0.3 ml methanol and 1.2 milliliters of tert-pentyl alcohols, are filled with N2Protection, after 130 DEG C of stirring reactions 15 hours, stop heating and Stirring, is cooled to room temperature, dilute reaction solution, filtering, vacuum rotary steam removal solvent, then by column chromatographic isolation and purification, obtain mesh Mark product, column chromatography eluent used is that volume ratio is 12:1 petroleum ether:Ethyl acetate mixed solvent, yield 56%.
Respectively as is illustrated by figs. 11 and 12, structural characterization data are as follows for the hydrogen spectrogram and carbon spectrogram of products therefrom：
1H NMR(400MHz,CDCl3):δ=7.79 (s, 1H), 5.44 (brs, 1H), 3.40 (s, 2H), 2.62 (t, J= 6.0Hz,2H),1.81-2.01(m,3H),0.96-1.14(m,2H),0.85-0.94(m,2H)。
13C NMR(101MHz,CDCl3):δ=169.24,159.93,152.73,109.68,41.11,23.30, 20.76,17.42,9.17。
IR(KBr):3204,3076,3004,2929,2850,1607,1556,1443,1352,1320,1236,1184, 1119,1018,883,787,695cm-1。
MS(EI,m/z):175[M]+。
HRMS(ESI):Calcd.for C10H13N3[M+H]+:176.1182；found:176.1182.
Infer that products therefrom obtains structure and is shown below according to data above：
Embodiment 7
0.5 mM of 6- methyl-2-amino -3- hydroxymethylpyridines, 0.75 mM of benzene first are added in schlenk pipes Nitrile, 0.25 mM of potassium tert-butoxide, 0.005 mM of ten ruthenium of dicarbapentaborane three, 0.015 mM of double diphenylphosphine -9 of 4,5-, 9- Dimethyl xanthene, 0.3 ml methanol and 1.2 milliliters of tert-pentyl alcohols, are filled with N2Protection, after 130 DEG C of stirring reactions 16 hours, stops Only heat and stir, be cooled to room temperature, dilute reaction solution, filtering, vacuum rotary steam removes solvent, then pure by column chromatography for separation Change, obtain target product, column chromatography eluent used is that volume ratio is 8:1 petroleum ether:Ethyl acetate mixed solvent, yield 48%.
Respectively as shown in Figure 13 and Figure 14, structural characterization data are as follows for the hydrogen spectrogram and carbon spectrogram of products therefrom：
1H NMR(400MHz,CDCl3):δ=8.22-8.37 (m, 2H), 8.05 (s, 1H), 7.37-7.49 (m, 3H), 5.40(brs,1H),3.50-3.67(m,1H),2.63-2.77(m,2H),1.92-2.02(m,1H),1.49-1.60(m,1H), 1.24 (d, J=6.4Hz, 3H).
13C NMR(101MHz,CDCl3):δ=162.63,160.22,153.27,138.44,129.76,128.26, 127.71,110.77,47.06,28.63,22.56,22.07。
IR(KBr):3221,3058,2926,2850,1600,1530,1419,1325,1222,1191,1159,759, 693cm-1。
MS(EI,m/z):225[M]+。
HRMS(ESI):Calcd.for C14H15N3[M+H]+:226.1339；found:226.1332.
Infer that products therefrom obtains structure and is shown below according to data above：
Embodiment 8
Added in schlenk pipes 0.5 mM of 2- methylol -3- aminopyridine, 0.75 mM of 4- methyl benzonitrile, 0.25 mM of potassium tert-butoxide, 0.005 mM of ten ruthenium of dicarbapentaborane three, 0.015 mM of double diphenylphosphine -9 of 4,5-, 9- diformazans Base xanthene, 0.3 ml methanol and 1.2 milliliters of tert-pentyl alcohols, are filled with N2Protection, after 130 DEG C of stirring reactions 12 hours, stop plus Heat and stirring, are cooled to room temperature, dilute reaction solution, filtering, vacuum rotary steam removal solvent, then by column chromatographic isolation and purification, obtain To target product, column chromatography eluent used is that volume ratio is 8:1 petroleum ether:Ethyl acetate mixed solvent, yield 55%.
Respectively as shown in Figure 15 and Figure 16, structural characterization data are as follows for the hydrogen spectrogram and carbon spectrogram of products therefrom：
1H NMR(400MHz,CDCl3):δ=8.15 (s, 2H), 7.96 (s, 1H), 7.22 (s, 2H), 3.93 (brs, 1H),3.33(s,2H),2.94(s,2H),2.38(s,3H),2.04(s,2H)。
13C NMR(101MHz,CDCl3):δ=154.32,150.09,141.13,138.60,137.34,135.65, 129.12,126.76,41.22,29.90,21.08。
IR(KBr):3256,3001,2928,2857,1589,1559,1502,1446,1347,1314,1265,1181, 1008,904,828,768cm-1。
MS(EI,m/z):225[M]+。
HRMS(ESI):Calcd.for C14H15N3[M+H]+:226.1339；found:226.1339.
The structure for inferring products therefrom according to data above is shown below：
Embodiment 9
Added in schlenk pipes 0.5 mM of 1- (PA) ethanol, 0.75 mM of 4- chlorobenzonitrile, 0.25 mM of potassium tert-butoxide, 0.005 mM of ten ruthenium of dicarbapentaborane three, 0.015 mM of double diphenylphosphine -9 of 4,5-, 9- diformazans Base xanthene, 0.3 ml methanol and 1.2 milliliters of tert-pentyl alcohols, are filled with N2Protection, after 140 DEG C of stirring reactions 20 hours, stop plus Heat and stirring, are cooled to room temperature, dilute reaction solution, filtering, vacuum rotary steam removal solvent, then by column chromatographic isolation and purification, obtain To target product, column chromatography eluent used is that volume ratio is 5:1 petroleum ether:Ethyl acetate mixed solvent, yield 76%.
Respectively as shown in Figure 17 and Figure 18, structural characterization data are as follows for the hydrogen spectrogram and carbon spectrogram of products therefrom：
1H NMR(400MHz,CDCl3):δ=8.24 (d, J=8.8Hz, 2H), 7.37 (d, J=8.4Hz, 2H), 5.45 (brs, 1H), 3.39 (s, 2H), 2.66 (t, J=6.4Hz, 2H), 2.36 (s, 3H), 1.87-2.04 (m, 2H).
13C NMR(101MHz,CDCl3):δ=161.70,160.44,160.13,137.15,135.63,129.11, 128.34,108.57,40.93,22.51,21.15,21.03。
IR(KBr):3246,2932,2847,1587,1415,1348,1244,1192,1163,1094,1009,783cm-1。
MS(EI,m/z):259[M]+。
HRMS(ESI):Calcd.for C14H14N3Cl[M+H]+:260.0949；found:260.0949.
The structure for inferring products therefrom according to data above is shown below：
Above-described embodiment is the present invention preferably implementation method, but embodiments of the present invention are not by above-described embodiment Limitation, it is other it is any without departing from Spirit Essence of the invention and the change, modification, replacement made under principle, combine, simplification, Equivalent substitute mode is should be, is included within protection scope of the present invention.

Claims (7)

1. one kind 5, the synthetic method of 6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines, it is characterised in that including as follows Step：
In the reactor, compound 1, compound 2, metallic catalyst, part and solvent are added, alkali is added for accelerator, is led to Enter inert gas, stirring reaction 1~48 hour at 40~150 DEG C, reaction is cooled to room temperature, dilute reaction solution, mistake after terminating Filter, removes solvent under reduced pressure and obtains crude product, and crude by column chromatography purification obtains 5,6,7,8- tetrahydropyridines simultaneously [2,3-d] miazines Compound；
Described compound 1 refers to the compound with structure shown in formula (1)；Described compound 2 refers to formula (2) structure Aromatic nitriles or alkyl nitrile；
In formula, X and Y is carbon atom or nitrogen-atoms；R1And R2It is methyl or hydrogen；R3For butyl, cyclopropyl, phenyl, 2- thienyls, 3- fluorophenyls, 3- cyanophenyls, 4- aminomethyl phenyls, 4- methoxyphenyls, 4- methyl mercaptos phenyl, 4- chlorphenyls, 4- bromophenyls, 4- Cyanophenyl, 4-N, N- 3,5-dimethylphenyls or 4- trifluoromethyls；
Described metallic catalyst is copper acetate, copper sulphate, iron chloride, palladium, bis-triphenylphosphipalladium palladium dichloride, cyclo-octadiene Double (the 4- isopropyl methyls phenyl) rutheniums of iridium chloride, iridous chloride, the ruthenium of ten dicarbapentaborane three, dichloro and bi triphenyl phosphine -1H- indenes chlorinations One or more mixing in ruthenium；
Described part is triphenylphosphine, Phen, the double hexichol of 1,4- double (diphenylphosphine) butane, 2- phenylpyridines and 4,5- One or more mixing in base phosphine -9,9- dimethyl xanthenes；
Described solvent be acetonitrile, tetrahydrofuran, N,N-dimethylformamide, dimethyl sulfoxide (DMSO), toluene, methyl alcohol, tert-pentyl alcohol and One or more mixing in water.
2. according to claim 1 a kind of 5, the synthetic method of 6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines, It is characterized in that：Described compound 1 is 2- amino -3- hydroxymethylpyridines, 2- methylol -3- aminopyridines, 6- methyl -2- ammonia Base -3- hydroxymethylpyridines or 1- (PA) ethanol.
3. according to claim 1 a kind of 5, the synthetic method of 6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines, It is characterized in that：Described reactor is managed for schlenk；Described inert gas is nitrogen or argon gas.
4. according to claim 1 a kind of 5, the synthetic method of 6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines, It is characterized in that：The compound 1 is 1 with the mol ratio of compound 2:(1~20).
5. according to claim 4 a kind of 5, the synthetic method of 6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines, It is characterized in that：The compound 1 is 1 with the mol ratio of compound 2:1.5.
6. according to claim 1 a kind of 5, the synthetic method of 6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines, It is characterized in that：The alkali is sodium carbonate, potassium carbonate, cesium carbonate, sodium methoxide, potassium tert-butoxide, sodium tert-butoxide, tert-butyl alcohol lithium, four One or more mixing in methyl ethylenediamine and triethylamine；The addition of alkali is (0.5 with the mol ratio of compound 1 ~5):1.
7. according to claim 1 a kind of 5, the synthetic method of 6,7,8- tetrahydropyridines simultaneously [2,3-d] pyrimidines, It is characterized in that：Described column chromatography purification eluent used is petroleum ether:The volume ratio of ethyl acetate is (0.5~50):1 Mixed solvent.
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