CN105726704A - A traditional Chinese medicine formula for treating severe acute pancreatitis and a preparing method thereof - Google Patents
A traditional Chinese medicine formula for treating severe acute pancreatitis and a preparing method thereof Download PDFInfo
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Abstract
The invention belongs to the technical fields of traditional Chinese medicine and traditional Chinese medicines and particularly relates to a traditional Chinese medicine formula for treating severe acute pancreatitis and a preparing method thereof. The traditional Chinese medicine formula is prepared from 5-8 parts of virgate wormwood herb, 5-8 parts of giant knotweed rhizome, 5-8 parts of rubus alceaefolius, 5-8 parts of radix bupleuri, 3-6 parts of fermented soybean, 3-6 parts of radix berberides wilsoneae, 3-5 parts of whiteflower cacalia seed, 3-5 parts of christina loosestrife, 3-6 parts of linseed, 3-6 parts of Chinese peony, 3-8 parts of rhubarb root and rhizome, 3-8 parts of crystallized sodium sulfate, 3-5 parts of danshen root, 3-5 parts of cape jasmine fruit and 3-5 parts of euphorbia kansui. The preparing method includes decocting with water. Through effects of regulating qi to alleviate mental depression, activating blood circulation to remove stasis, tonifying qi and rescuing yin of the traditional Chinese medicines, the traditional Chinese medicine formula is capable of reducing secretion of pancreatic juice, quickly regulating self inflammatory responses, preventing endotoxin translocation, relieving pain of patients and saving the life of patients.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, particularly to a kind of Chinese medicine formula treating Severe Acute Pancreatitis SAP and preparation method thereof.
Background technology
Acute pancreatitis is that Different types of etiopathogenises causes that pancreatin causes pancreatic tissue autodigestion, edema, hemorrhage even downright bad inflammatory reaction after being activated in pancreas.Clinical increase etc. as feature with acute upper abdominal pain, Nausea and vomiting, heating and blood pancreatin.Not etc., the lighter is not based on pancreas edema, clinical common for lesion degree weight, the state of an illness often in self limiting, prognosis bona, be also called mild acute pancreatitis.The pancreatic hemorrhage of minority severe one is downright bad, normal secondary infection, peritonitis and shock etc., and case fatality rate is high, is called Severe Acute Pancreatitis SAP.
The Severe Acute Pancreatitis SAP of 70%～80% is caused by biliary tract, excessive drinking and eating and drinking too much at one meal, pathogenesis is mainly the pancreatic juice result to pancreas and surrounding tissue autodigestion thereof, inflammatory cytokine is interrelated and cumulative function, causes the generation of the crisis such as vascular leakage, Hypovolemia, multiple system organ failure.The most basic most important link for the treatment of acute pancreatitis is to reduce pancreatic secretion, Chinese patent (CN103191322A) discloses a kind of Chinese medicine treating Severe Acute Pancreatitis SAP, by improve serious symptom urgency patient gastrointestinal function, suppress Digestive system secretion, suppress tryptic activity, thus alleviating pancreatic tissue inflammation, reducing the order of severity of the state of an illness, but Severe Acute Pancreatitis SAP rapid onset, development are rapidly, need fast onset, contain PD rapidly, it is possible to the medicine of recuperating depleted YANG and rescuing the patient from collapse is treated.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine formula treating Severe Acute Pancreatitis SAP, by the regulating the flow of QI to alleviate depression of Chinese medicine, blood circulation promoting and blood stasis dispelling, benefiting QI and recuperating YIN-fluid effect, it is possible to reduce pancreatic juice glandular secretion, quickly regulate auto-inflammatory reaction, prevention Endotoxin Translocation, alleviates patient's misery, saves patients ' lives.
The present invention provides a kind of Chinese medicine formula treating Severe Acute Pancreatitis SAP, formulated by the raw material of Chinese medicine of following parts by weight: Herba Artemisiae Scopariae 5～8 parts, Rhizoma Polygoni Cuspidati 5～8 parts, Radix seu Folium Rubi alceaefolii 5～8 parts, Radix Bupleuri 5～8 parts, tasteless preserved soybean 3～6 parts, little Radix Berberidis 3～6 parts, Semen Caesalpiniae Minacis 3～5 parts, Herba Lysimachiae 3～5 parts, Semen Lini 3～6 parts, Radix Paeoniae 3～6 parts, Radix Et Rhizoma Rhei 3～8 parts, 3～8 parts of Natrii Sulfas, Radix Salviae Miltiorrhizae 3～5 parts, Fructus Gardeniae 3～5 parts, Radix Kansui 3～5 parts.
It is preferred that be that the raw material of Chinese medicine by following parts by weight is formulated: Herba Artemisiae Scopariae 7 parts, Rhizoma Polygoni Cuspidati 6 parts, Radix seu Folium Rubi alceaefolii 6 parts, Radix Bupleuri 7 parts, tasteless preserved soybean 4 parts, little Radix Berberidis 4 parts, Semen Caesalpiniae Minacis 4 parts, Herba Lysimachiae 4 parts, Semen Lini 5 parts, Radix Paeoniae 5 parts, Radix Et Rhizoma Rhei 6 parts, 5 parts of Natrii Sulfas, Radix Salviae Miltiorrhizae 4 parts, Fructus Gardeniae 4 parts, Radix Kansui 4 parts.
Preparation method following steps form: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 2～5cm, and soaked 1～2 hour；Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20～40min to；After cooked, leach medicine juice and decoct as head；Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Pharmacology analysis:
Herba Artemisiae Scopariae: bitter, pungent, is slightly cold.Return spleen, stomach, liver, gallbladder meridian.Clearing away heat-damp and promoting diuresis；Jaundice eliminating.Cure mainly jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis etc..Pharmaceutical research has function of gallbladder promoting, liver function protecting, and antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, coronary dilating etc. acts on.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature；Return liver, gallbladder, lung meridian.Effect dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, relieving cough and resolving phlegm；For jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea, lump in the abdomen, instep beats damage, cough due to lung-heat.
Radix seu Folium Rubi alceaefolii: sweet light is flat.Function blood circulation promoting and blood stasis dispelling, clearing away heat to stop bleeding；Treating acute and chronic hepatitis, hepatosplenomegaly, march hemoglobinuria, mastitis, traumatic hemorrhage, stomatitis.
Radix Bupleuri: nature and flavor are bitter, are slightly cold.Return liver, gallbladder meridian.There is reconciling superficies and interior, soothing the liver, effect of yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.
Tasteless preserved soybean: bitter in the mouth, cold, nontoxic；Enter lung, stomach warp.Effect is induced sweat, relieving restlessness, Xuan Yu, removing toxic substances；Cure mainly typhoid fever calentura, cold and heat, have a headache, irritated, uncomfortable in chest.
Little Radix Berberidis: bitter, cold.Function heat-clearing and toxic substances removing, antiinflammatory, dysentery relieving；Curing mainly dysentery, sore, carbuncle and painful swelling, conjunctivitis, children's's oral erosion, enteritis, pneumonia, upper respiratory tract infection, acute binding film is scorching, mastitis, acute icterohepatitis, furuncle.
Semen Caesalpiniae Minacis: property bitter cold, has dissipating blood stasis, pain relieving, heat clearing away, the effect dried.
Herba Lysimachiae: sweet in the mouth, micro-hardship, cool in nature；Return liver, gallbladder, kidney, bladder warp.Effect relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling；Cure mainly liver and gall and urinary system calculus, pyretic stranguria, oedema due to nephritis, jaundice due to damp-heat, sore carbuncle, venom, traumatic injury.
Semen Lini: sweet in the mouth, tepor, nontoxic；Return lung, liver, large intestine channel.There are lubrication, abirritant effect, can be used for treating local inflammation.
Radix Paeoniae: Radix Paeoniae contains the multi-medicament composition such as peoniflorin and paeoniflorin, has the effect of expansion blood vessel, blood pressure lowering analgesia, heat clearing away spasmolytic, has higher medical value.
Radix Et Rhizoma Rhei: bitter in the mouth, cold；Return spleen, stomach, large intestine, liver, pericardium channel.Effect is attacked stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances；Cure mainly excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, spit blood, spitting of blood, epistaxis, have blood in stool, hematuria, blood-retention, amenorrhea, puerperal the stagnant stomachache of the stasis of blood, lump in the abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, scald.
Natrii Sulfas: salty, bitter, cold；Return stomach warp, lung meridian, spleen channel, kidney channel, small intestine meridian, tri-jiao channel, large intestine channel.Function purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat, cure mainly brokenly painful abdominal mass, in room temperature, help digestion, relieve oedema or abdominal distension through diuresis or purgation, cathartic.For gastral cavilty painful abdominal mass, eat painful abdominal mass, dyspepsia, edema, edema, swelling of the breast, amenorrhea, constipation.
Radix Salviae Miltiorrhizae: nature and flavor are bitter, are slightly cold；GUIXIN, Liver Channel.There are stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris.
Fructus Gardeniae: heat clearing away, pathogenic fire purging, removing heat from blood；Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, haematemesis, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprain and swell and ache, there is the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence.
Radix Kansui: bitter in the mouth；Cold in nature, poisonous；Return spleen channel, lung meridian, kidney channel, bladder warp, large intestine channel, small intestine meridian.Function removing water retention by purgation by swollen, dispersing swelling and dissipating binds；Cure mainly edema, ascites, prolonged fluid-retention blocked-up chest, epilepsy, breath with cough, sphincter disturbance.
The Chinese medicine of the present invention, by the regulating the flow of QI to alleviate depression of Chinese medicine, blood circulation promoting and blood stasis dispelling, benefiting QI and recuperating YIN-fluid effect, it is possible to reduce pancreatic juice glandular secretion, quickly regulate auto-inflammatory reaction, prevent Endotoxin Translocation, alleviate patient's misery, save patients ' lives.
Outcome measure:
Effective: in 3 days, symptom, sign are alleviated, and in 7 days, blood, amylase in urine recover normal substantially.
Effective: in 7 days, symptom, sign alleviate, blood, amylase in urine have downward trend；
Invalid: in 7 days, symptom does not alleviate or worsens；
Therapeutic outcome: treat 129 severe acute pancreatitis, 1st is 1 course for the treatment of, 1 day 2 doses.After taking medicine of the present invention, effective 62 examples, account for 48.1%, effective 65 examples, account for 50.4%, invalid 2 examples, account for 1.5%.
Attached a few example case is described further:
Case 1: grandson so-and-so, female, 52 years old, latter 1 hour upper abdomen center dull pain of taking food before 2 days, increase the weight of gradually, in persistence, radiate to lower back, lie on the back, increase the weight of when coughing or be movable, accompany low grade fever, feel sick, frequently vomit, discharge food, gastric juice and bile, after telling, stomachache is without alleviating, and repeatedly uses analgesic invalid.Result of having a medical check-up shows T39 DEG C, P104 beat/min, R19 beat/min, Bp130/80mmHg, face of acute ill, curling position of lying on one's side, xerosis cutis, without petechia, superficial lymph knot does not touch, and sclera is without xanthochromia, and cardiopulmonary are without exception, and abdomen is smooth, epigastrium is slight muscle tonus, tenderness is obvious, suspicious rebound tenderness, not touching lump, Murphy levies feminine gender, and Liver and kidney district is without substantially kowtowing pain, shifting dullness probable positive, borborygmus is slightly weak, double; two lower limb pneumonedema.Diagnosis is acute critical pancreatitis, then gives treatment by Chinese herbs of the present invention, and effective after 3 days, inflammatory reaction is blocked, and after 7 days, blood, amylase in urine recover normal substantially.
Case 2: Hu, male, 60 years old, morbidity broke out tormina without obvious inducement the same day, under chronognosis xiphoid-process to the right in ictal distending pain, stomachache involves rapidly full abdominal part and changes into persistence, and the sample that lancinates has an intense pain, and radiate to back, accompany Nausea and vomiting, discharge gastric content.Not defecation and aerofluxus since morbidity, and dare not stand up and also dare not deeply breathe, more dare not make abdominal part pressurized.Before 12 hours, stomachache increases the weight of and dysphoria occurs, feels suffocated, and companion body temperature rise emergency treatment then, disconnected disease is Severe Acute Pancreatitis SAP, then gives treatment by Chinese herbs of the present invention, and effective after 3 days, inflammatory reaction is blocked, and after 5 days, blood, amylase in urine recover normal substantially.
Detailed description of the invention
Embodiment 1:
A kind of Chinese medicine formula treating Severe Acute Pancreatitis SAP, formulated by the raw material of Chinese medicine of following parts by weight: Herba Artemisiae Scopariae 7 parts, Rhizoma Polygoni Cuspidati 6 parts, Radix seu Folium Rubi alceaefolii 6 parts, Radix Bupleuri 7 parts, tasteless preserved soybean 4 parts, little Radix Berberidis 4 parts, Semen Caesalpiniae Minacis 4 parts, Herba Lysimachiae 4 parts, Semen Lini 5 parts, Radix Paeoniae 5 parts, Radix Et Rhizoma Rhei 6 parts, 5 parts of Natrii Sulfas, Radix Salviae Miltiorrhizae 4 parts, Fructus Gardeniae 4 parts, Radix Kansui 4 parts.
Preparation method following steps form: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 4cm, and soaked 1.5 hours；Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 30min to；After cooked, leach medicine juice and decoct as head；Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Embodiment 2:
A kind of Chinese medicine formula treating Severe Acute Pancreatitis SAP, formulated by the raw material of Chinese medicine of following parts by weight: Herba Artemisiae Scopariae 5 parts, Rhizoma Polygoni Cuspidati 8 parts, Radix seu Folium Rubi alceaefolii 5 parts, Radix Bupleuri 8 parts, tasteless preserved soybean 3 parts, little Radix Berberidis 6 parts, Semen Caesalpiniae Minacis 3 parts, Herba Lysimachiae 5 parts, Semen Lini 3 parts, Radix Paeoniae 6 parts, Radix Et Rhizoma Rhei 3 parts, 8 parts of Natrii Sulfas, Radix Salviae Miltiorrhizae 3 parts, Fructus Gardeniae 5 parts, Radix Kansui 3 parts.
Preparation method following steps form: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 2cm, and soaked 2 hours；Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20min to；After cooked, leach medicine juice and decoct as head；Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Embodiment 3:
A kind of Chinese medicine formula treating Severe Acute Pancreatitis SAP, formulated by the raw material of Chinese medicine of following parts by weight: Herba Artemisiae Scopariae 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Radix seu Folium Rubi alceaefolii 8 parts, Radix Bupleuri 5 parts, tasteless preserved soybean 6 parts, little Radix Berberidis 3 parts, Semen Caesalpiniae Minacis 5 parts, Herba Lysimachiae 3 parts, Semen Lini 6 parts, Radix Paeoniae 3 parts, Radix Et Rhizoma Rhei 8 parts, 3 parts of Natrii Sulfas, Radix Salviae Miltiorrhizae 5 parts, Fructus Gardeniae 3 parts, Radix Kansui 5 parts.
Preparation method following steps form: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 5cm, and soaked 1 hour；Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 40min to；After cooked, leach medicine juice and decoct as head；Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Below the present invention is described in detail, the above, it is only the preferred embodiments of the invention, when the scope of the present invention can not be limited, namely all done impartial change according to the application scope and modify, all should still belong in covering scope of the present invention.
Claims (3)
1. the Chinese medicine formula treating Severe Acute Pancreatitis SAP, it is characterised in that formulated by the raw material of Chinese medicine of following parts by weight: Herba Artemisiae Scopariae 5～8 parts, Rhizoma Polygoni Cuspidati 5～8 parts, Radix seu Folium Rubi alceaefolii 5～8 parts, Radix Bupleuri 5～8 parts, tasteless preserved soybean 3～6 parts, little Radix Berberidis 3～6 parts, Semen Caesalpiniae Minacis 3～5 parts, Herba Lysimachiae 3～5 parts, Semen Lini 3～6 parts, Radix Paeoniae 3～6 parts, Radix Et Rhizoma Rhei 3～8 parts, 3～8 parts of Natrii Sulfas, Radix Salviae Miltiorrhizae 3～5 parts, Fructus Gardeniae 3～5 parts, Radix Kansui 3～5 parts.
2. a kind of Chinese medicine formula treating Severe Acute Pancreatitis SAP as claimed in claim 1, it is characterised in that formulated by the raw material of Chinese medicine of following parts by weight: Herba Artemisiae Scopariae 7 parts, Rhizoma Polygoni Cuspidati 6 parts, Radix seu Folium Rubi alceaefolii 6 parts, Radix Bupleuri 7 parts, tasteless preserved soybean 4 parts, little Radix Berberidis 4 parts, Semen Caesalpiniae Minacis 4 parts, Herba Lysimachiae 4 parts, Semen Lini 5 parts, Radix Paeoniae 5 parts, Radix Et Rhizoma Rhei 6 parts, 5 parts of Natrii Sulfas, Radix Salviae Miltiorrhizae 4 parts, Fructus Gardeniae 4 parts, Radix Kansui 4 parts.
3. the method for the preparation Chinese medicine formula treating Severe Acute Pancreatitis SAP as claimed in claim 1, it is characterised in that be made up of following steps: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 2～5cm, and soaked 1～2 hour；Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20～40min to；After cooked, leach medicine juice and decoct as head；Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
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| CN201410757101.3A CN105726704A (en) | 2014-12-10 | 2014-12-10 | A traditional Chinese medicine formula for treating severe acute pancreatitis and a preparing method thereof |
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| CN201410757101.3A CN105726704A (en) | 2014-12-10 | 2014-12-10 | A traditional Chinese medicine formula for treating severe acute pancreatitis and a preparing method thereof |
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Application publication date: 20160706 |