CN105709458A - Experimental device for conducting solid-phase extraction on blood sample - Google Patents
Experimental device for conducting solid-phase extraction on blood sample Download PDFInfo
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- CN105709458A CN105709458A CN201610075636.1A CN201610075636A CN105709458A CN 105709458 A CN105709458 A CN 105709458A CN 201610075636 A CN201610075636 A CN 201610075636A CN 105709458 A CN105709458 A CN 105709458A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/405—Concentrating samples by adsorption or absorption
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Abstract
The invention discloses an experimental device for conducting solid-phase extraction on a blood sample.The experimental device can enable operation of achieving solid-phase extraction of the blood sample to be more convenient and rapid, the sample pretreatment speed is greatly increased, the work efficiency is improved, and the experimental device is very practical in the pretreatment process of large-batch samples.By means of using of a high-penetrability flexible sieve plate, passing of macromolecules is convenient, polar molecules can be washed easily, extraction separation of samples which are large in size and are prone to dissociation in a blood sample substrate is convenient, substances with large sizes can be effectively extracted and separated, dissociation of pharmaceutic preparation which are prone to decomposition can be avoided, and a detection deviation in the metabolic process is reduced.
Description
Technical field
The present invention relates to Experiment of Analytical Chemistry pretreatment technology field, particularly relate to a kind of experimental provision that blood sample is carried out Solid-Phase Extraction.
Background technology
Solid-Phase Extraction (Solid-PhaseExtraction, SPE) is the sorption extraction process of a kind of absorption-washing-eluting, is a kind of sample pretreatment technology, can sample be easily separated, purification and concentration.Solid phase is bigger than the solvent of separated and dissolved thing to the absorption affinity of separator, improves the goal object response rate, can more effectively goal object be separated with chaff interference compared with liquid-liquid extraction method.Therefore, solid phase extraction techniques is widely used in the various aspects such as environment measuring analysis, food analysis, pharmaceutical analysis.
Solid-Phase Extraction experimentation need certain device to place solid-phase extraction column, container etc., in order to complete operation quickly and easily.But in real work, being all by the homemade easy device of carton or plank, can only place several pillars, and be the pillar of single specification, pillar can not be connected use, can not place associated vessel, therefore, its function singleness, operation inconvenience, inefficiency.In blood, the extraction of sample and analysis are analysis and processing methods necessary in pharmacokinetics and metabolism group etc..Owing to blood sample substrate is complicated, current commercialization solid phase extraction column stuffing is fine and close, it is difficult to large-sized material (such as liposome) is carried out effective extract and separate.And labile pharmaceutical preparation also can produce dissociating in various degree, cause deviation is produced for the detection in metabolic process.For the problems referred to above, process this field at blood sample, it is provided that a kind of solid phase extraction method that can efficiently separate large scale, easy dissociation substance, the research for some pharmacokinetics has great significance.
Summary of the invention
For overcoming above technical problem, the invention provides a kind of experimental provision that blood sample is carried out Solid-Phase Extraction.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of experimental provision that blood sample carries out Solid-Phase Extraction, including the first solid-phase extraction column, second solid phase extraction column and vacuum tank；
Described first solid-phase extraction column is connected with second solid phase extraction column by sleeve pipe of transferring, described switching sleeve pipe is hollow circular column jecket, the outer wall of the joint of described first solid-phase extraction column connects with the inner wall tightening of switching sleeve pipe, the inwall of described second solid phase extraction column connects with the outer wall fastening of switching sleeve pipe, and described switching sleeve pipe and the first solid-phase extraction column and second solid phase extraction column joint are provided with sealing ring；
Described first solid-phase extraction column (1) and second solid phase extraction column (2) are the double-deck solid-phase extraction columns equipped with different fillers being provided with sieve plate, including: bottom sieve plate (26), are positioned at the fixed screen deck (28) above the nonpolar silica-based filler (27) of bottom, ground floor filler and are positioned at the water absorption filler (29) above fixed screen deck (28)；Described sieve plate is high-penetrability flexibility sieve plate；
The top of described vacuum tank is fastenedly connected with cover plate, and the sidewall at described vacuum tank top is provided with clamp, and described lid is slidably fixed on described clamp, and the junction of described cover plate and described vacuum tank is provided with sealing gasket；Described cover plate is evenly arranged with multiple through hole, it is inserted with hollow sleeve in described through hole, described hollow sleeve is the hollow column jecket that gradient is shunk, the tip size of described hollow sleeve is wider than described through hole, the top of described hollow sleeve connects with the fastening of described second solid phase extraction column, and link is positioned at outside vacuum tank, the outer wall of joint of described second solid phase extraction column connects with the inner wall tightening of hollow sleeve, the bottom of described hollow sleeve extends in collecting pipe, and described hollow sleeve is provided with sealing ring with second solid phase extraction column and through hole joint；
The bottom of described vacuum tank is provided with collecting tank and position, the hole plate of replaceable use, and the left and right inside sidewalls of described vacuum tank is provided with gathering sill, described collecting tank and position, hole plate and is slidably fixed on the sidewall of vacuum tank by gathering sill；The described collecting tank left and right sides is provided with the clamping suitable with gathering sill；On the plate of position, described hole, the position of corresponding described through hole is provided with jack correspondingly, and described collecting pipe is fixed on jack；
On the sidewall of described vacuum tank gathering sill be arranged over bleeding point, described bleeding point is connected with vacuum pump by exhaust tube, and described exhaust tube is provided with VRV and surge flask；The sidewall of described vacuum tank is rotatably connected to hermatic door；The bottom of described vacuum tank is provided with universal wheel.
As preferably, described universal wheel has 4；
As preferably, described hermatic door being provided with swing handle；
As preferably, the sidewall of described hermatic door is provided with sealing gasket；
As preferably, described collecting pipe is test tube, beaker or centrifuge tube；
As preferably, described high-penetrability flexibility sieve plate is that the thread non-woven material of macromolecule is prepared into；
As preferably, described water absorption packing material size is between 200-300 order；
As preferably, the particle diameter of described nonpolar silica-based filler dry powder is 30-50 μm；
As preferably, described water absorption filler is the one in calcium oxide, sodium hydroxide, anhydrous magnesium sulfate, solid calcium chloride and solid magnesium chloride.
The invention has the beneficial effects as follows:
A kind of experimental provision that blood sample carries out Solid-Phase Extraction of the present invention can make the operation of blood sample Solid-Phase Extraction become very convenient, quick, is greatly accelerated sample pre-treatments speed, improves work efficiency, very useful in batch samples pretreatment process.Owing to employing hollow sleeve, it is possible to prevent because there is cross-contamination in the joint portion of pillar with vacuum tank cover plate through hole when changing solid-phase extraction column.The use of switching sleeve pipe can also realize the series connection of different size extraction column and use.The slidably design of clamp, position, hole plate and collecting tank, and the design of hermatic door, it may be achieved extraction column and collection device replace convenient purpose.The use equipped with the double-deck solid-phase extraction column of different fillers being provided with sieve plate can realize the absorption to different material, facilitate moisture impurity in organic sample to remove with the double-deck solid-phase extraction column of water absorption filler equipped with positive sorptive filler to realize sample simultaneously and cross post and separate, enriching the range of application of solid-phase extraction column, adsorbed impurity species increases.The use of high-penetrability flexibility sieve plate, it is easy to passing through of macromole, also polar molecule can be made very easily to wash, be easy in blood sample substrate large scale, legibility separates from the extraction of sample, large-sized material (such as liposome) can be carried out effective extract and separate, and can avoid easily decomposing dissociating of pharmaceutical preparation, reduce the detection error in metabolic process.
Accompanying drawing explanation
Fig. 1 is the structural representation of the embodiment of the present invention.
Fig. 2 is the cross-sectional view of the embodiment of the present invention.
Fig. 3 is the structural representation of embodiment of the present invention collecting tank.
In figure: 1: the first solid-phase extraction column 2: second solid phase extraction column 3: vacuum tank 4: joint 5: sealing ring 6: cover plate 7: clamp 8: sealing gasket 9: through hole 10: hollow sleeve 11: collecting pipe 12: collecting tank 13: position, hole plate 14: gathering sill 15: card adapter plate 16: jack 17: hermatic door 18: bleeding point 19: exhaust tube 20: vacuum pump 21: VRV 22: surge flask 23: universal wheel 24: swing handle 25: switching sleeve pipe 26: bottom sieve plate 27: nonpolar silica-based filler 28: fixed screen deck 29: water absorption filler.
Detailed description of the invention
Below in conjunction with embodiment, and in conjunction with accompanying drawing, technical scheme is further elaborated with.
As it is shown in figure 1, a kind of experimental provision that blood sample is carried out Solid-Phase Extraction, including the first solid-phase extraction column 1, second solid phase extraction column 2 and vacuum tank 3；
Described first solid-phase extraction column 1 is connected with second solid phase extraction column 2 by sleeve pipe 25 of transferring, described switching sleeve pipe 25 is hollow circular column jecket, the outer wall of the joint 4 of described first solid-phase extraction column 1 connects with the inner wall tightening of switching sleeve pipe 25, the inwall of described second solid phase extraction column 2 connects with the outer wall fastening of switching sleeve pipe 25, and described switching sleeve pipe 25 and the first solid-phase extraction column 1 and second solid phase extraction column 2 joint are provided with sealing ring 5；
Described first solid-phase extraction column 1 and second solid phase extraction column 2 are the double-deck solid-phase extraction columns equipped with different fillers being provided with sieve plate, including: bottom sieve plate 26, are positioned at the fixed screen deck 28 above the nonpolar silica-based filler 27 of bottom, ground floor filler and are positioned at the water absorption filler 29 above fixed screen deck 28；Described sieve plate is high-penetrability flexibility sieve plate；
The top of described vacuum tank 3 is fastenedly connected with cover plate 6, and the sidewall at described vacuum tank 3 top is provided with clamp 7, and described cover plate 6 is slidably fixed on described clamp 7, and the junction of described cover plate 6 and described vacuum tank 3 is provided with sealing gasket 8；Described cover plate 6 is evenly arranged with 3 through holes 9, it is inserted with hollow sleeve 10 in described through hole 9, described hollow sleeve 10 is the hollow column jecket that gradient is shunk, the tip size of described hollow sleeve 10 is wider than described through hole 9, the top of described hollow sleeve 10 connects with the fastening of described second solid phase extraction column 2, and link is positioned at vacuum tank 3 outside, the outer wall of the joint 4 of described second solid phase extraction column 2 connects with the inner wall tightening of hollow sleeve 10, the bottom of described hollow sleeve 10 extends in collecting pipe 11, described hollow sleeve 10 is provided with sealing ring 5 with second solid phase extraction column 2 and through hole 9 joint；
The bottom of described vacuum tank 3 is provided with collecting tank 12 and position, the hole plate 13 of replaceable use, and the left and right inside sidewalls of described vacuum tank 3 is provided with gathering sill 14, described collecting tank 12 and position, hole plate 13 and is slidably fixed on the sidewall of vacuum tank 3 by gathering sill 14；Described collecting tank 12 left and right sides is provided with the card adapter plate 15 suitable with gathering sill 14；On position, described hole plate 13, the position of corresponding described through hole 9 is provided with 3 jacks 16 correspondingly, and described collecting pipe 11 is fixed on jack 16；On the sidewall of described vacuum tank 3 gathering sill 14 be arranged over bleeding point 18, described bleeding point 18 is connected with vacuum pump 20 by exhaust tube 19, and described exhaust tube 19 is provided with VRV 21 and surge flask 22；Being rotatably connected to hermatic door 17 on the sidewall of described vacuum tank 3, state and be provided with swing handle on hermatic door, the sidewall of described hermatic door is provided with sealing gasket；The bottom of described vacuum tank 3 is provided with universal wheel 23, it is preferred that described universal wheel has 4；Described collecting pipe can be test tube, beaker or centrifuge tube；Preferably, described high-penetrability flexibility sieve plate is that the thread non-woven material of macromolecule is prepared into, and described water absorption packing material size is between 200-300 order；Preferably, the particle diameter of described nonpolar silica-based filler dry powder is 30-50 μm；Described water absorption filler is the one in calcium oxide, sodium hydroxide, anhydrous magnesium sulfate, solid calcium chloride and solid magnesium chloride.
Claims (9)
1. the experimental provision that blood sample is carried out Solid-Phase Extraction, it is characterised in that: include the first solid-phase extraction column (1), second solid phase extraction column (2) and vacuum tank (3)；
Described first solid-phase extraction column (1) is connected with second solid phase extraction column (2) by sleeve pipe (25) of transferring, described switching sleeve pipe (25) is hollow circular column jecket, the outer wall of the joint (4) of described first solid-phase extraction column (1) connects with the inner wall tightening of switching sleeve pipe (25), the inwall of described second solid phase extraction column (2) connects with the outer wall fastening of switching sleeve pipe (25), and described switching sleeve pipe (25) is provided with sealing ring (5) with the first solid-phase extraction column (1) and second solid phase extraction column (2) joint；
Described first solid-phase extraction column (1) and second solid phase extraction column (2) are the double-deck solid-phase extraction columns equipped with different fillers being provided with sieve plate, including: bottom sieve plate (26), are positioned at the fixed screen deck (28) above the nonpolar silica-based filler (27) of bottom, filler and are positioned at the water absorption filler (29) above fixed screen deck (28)；Described sieve plate is high-penetrability flexibility sieve plate；
The top of described vacuum tank (3) is fastenedly connected with cover plate (6), the sidewall at described vacuum tank (3) top is provided with clamp (7), described cover plate (6) is slidably fixed on described clamp (7), and the junction of described cover plate (6) and described vacuum tank (3) is provided with sealing gasket (8)；Described cover plate (6) is evenly arranged with multiple through hole (9), hollow sleeve (10) it is inserted with in described through hole (9), described hollow sleeve (10) is the hollow column jecket that gradient is shunk, the tip size of described hollow sleeve (10) is wider than described through hole (9), the top of described hollow sleeve (10) connects with the fastening of described second solid phase extraction column (2), and link is positioned at vacuum tank (3) outside, the outer wall of the joint (4) of described second solid phase extraction column (2) connects with the inner wall tightening of hollow sleeve (10), the bottom of described hollow sleeve (10) extends in collecting pipe (11), described hollow sleeve (10) is provided with sealing ring (5) with second solid phase extraction column (2) and through hole (9) joint；
The bottom of described vacuum tank (3) is provided with collecting tank (12) and the position, hole plate (13) of replaceable use, the left and right inside sidewalls of described vacuum tank (3) is provided with gathering sill (14), described collecting tank (12) and position, hole plate (13) and is slidably fixed on the sidewall of vacuum tank (3) by gathering sill (14)；Described collecting tank (12) left and right sides is provided with the card adapter plate (15) suitable with gathering sill (14)；The position of the upper corresponding described through hole (9) in position, described hole plate (13) is provided with jack (16) correspondingly, and described collecting pipe (11) is fixed on jack (16)；
On the sidewall of described vacuum tank (3), gathering sill (14) is arranged over bleeding point (18), described bleeding point (18) is connected with vacuum pump (20) by exhaust tube (19), and described exhaust tube (19) is provided with VRV (21) and surge flask (22)；The sidewall of described vacuum tank (3) is rotatably connected to hermatic door (17)；The bottom of described vacuum tank (3) is provided with universal wheel (23).
2. a kind of experimental provision that blood sample is carried out Solid-Phase Extraction as claimed in claim 1, it is characterised in that: described universal wheel (23) has 4.
3. a kind of experimental provision that blood sample is carried out Solid-Phase Extraction as claimed in claim 1, it is characterised in that: described hermatic door (17) is provided with swing handle (24).
4. a kind of experimental provision that blood sample is carried out Solid-Phase Extraction as claimed in claim 1, it is characterised in that: the sidewall of described hermatic door (17) is provided with sealing gasket.
5. a kind of experimental provision that blood sample is carried out Solid-Phase Extraction as claimed in claim 1, it is characterised in that: described collecting pipe (11) is test tube, beaker or centrifuge tube.
6. a kind of experimental provision that blood sample is carried out Solid-Phase Extraction as described in any one of claim 1-5, it is characterised in that: described high-penetrability flexibility sieve plate is that the thread non-woven material of macromolecule is prepared into.
7. a kind of experimental provision that blood sample is carried out Solid-Phase Extraction as claimed in claim 1, it is characterised in that: described water absorption packing material size is between 200-300 order.
8. a kind of experimental provision that blood sample is carried out Solid-Phase Extraction as claimed in claim 1, it is characterised in that: the particle diameter of described nonpolar silica-based filler dry powder is 30-50 μm.
9. a kind of experimental provision that blood sample is carried out Solid-Phase Extraction as claimed in claim 1, it is characterised in that: described water absorption filler is the one in calcium oxide, sodium hydroxide, anhydrous magnesium sulfate, solid calcium chloride and solid magnesium chloride.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610075636.1A CN105709458B (en) | 2016-02-03 | 2016-02-03 | A kind of experimental provision that Solid Phase Extraction is carried out to blood sample |
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| CN201610075636.1A CN105709458B (en) | 2016-02-03 | 2016-02-03 | A kind of experimental provision that Solid Phase Extraction is carried out to blood sample |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641971A (en) * | 2016-03-21 | 2016-06-08 | 河南师范大学 | Integral solid-phase extraction device |
| CN107748099A (en) * | 2017-10-20 | 2018-03-02 | 西北大学 | A kind of self-heating solid phase saponifiable extraction column preparation method for blood sample pre-treatment |
| CN108225883A (en) * | 2016-12-09 | 2018-06-29 | 中国科学院大连化学物理研究所 | A kind of Solid Phase Extraction and purging integrated apparatus and application method |
| CN109100203A (en) * | 2018-08-22 | 2018-12-28 | 佛山科学技术学院 | A kind of solid-phase extraction column for residue of veterinary drug measurement |
| CN109163951A (en) * | 2018-11-05 | 2019-01-08 | 长沙都正医学检验有限责任公司 | A kind of preparation facilities of TMAO negative sample |
| CN114034537A (en) * | 2021-09-16 | 2022-02-11 | 拉萨海关技术中心 | Solid phase extraction equipment for food detection and separation method |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641971A (en) * | 2016-03-21 | 2016-06-08 | 河南师范大学 | Integral solid-phase extraction device |
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| CN109100203A (en) * | 2018-08-22 | 2018-12-28 | 佛山科学技术学院 | A kind of solid-phase extraction column for residue of veterinary drug measurement |
| CN109163951A (en) * | 2018-11-05 | 2019-01-08 | 长沙都正医学检验有限责任公司 | A kind of preparation facilities of TMAO negative sample |
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| CN114034537A (en) * | 2021-09-16 | 2022-02-11 | 拉萨海关技术中心 | Solid phase extraction equipment for food detection and separation method |
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| CN105709458B (en) | 2018-06-29 |
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