CN105641971A - Integral solid-phase extraction device - Google Patents
Integral solid-phase extraction device Download PDFInfo
- Publication number
- CN105641971A CN105641971A CN201610160323.6A CN201610160323A CN105641971A CN 105641971 A CN105641971 A CN 105641971A CN 201610160323 A CN201610160323 A CN 201610160323A CN 105641971 A CN105641971 A CN 105641971A
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- solid
- phase extraction
- baffle plate
- extraction column
- hole
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
- G01N2030/062—Preparation extracting sample from raw material
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- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
The invention discloses an integral solid-phase extraction device, which comprises vertical plates, a solid-phase extraction post baffle plate and a conical flask baffle plate, wherein the solid-phase extraction post baffle plate is fixed between the vertical plates and is arranged at the upper parts of the vertical plates; dense through holes are formed in one side of the solid-phase extraction post baffle plate; dispersed through holes are formed in the other side of the solid-phase extraction post baffle plate; a rubber pipe is fixed in a rubber pipe clamp groove and a rubber pipe fixing groove; a connecting hole with an upward opening is formed in the rubber pipe; one end of the rubber pipe is sealed through a corrosion-resistant polyfluortetraethylene plug; the other end of the rubber pipe passes through openings formed in the vertical plates to be connected with a liquid inlet of a conical flask; a gas extraction opening of the conical flask is connected with a vacuum pump; the conical flask baffle plate is arranged under the dispersed through holes; conical flask carrying holes opposite to the dispersed through holes are formed in the conical flask baffle plate. The integral solid-phase extraction device has the advantages that the use is simple and convenient; the cost is low; safety is realized; the environment is protected; activation, enrichment and elution can be performed; most steps of solid-phase extraction are completed.
Description
Technical field
The present invention relates to one utilizes solid adsorbent that sample is carried out pretreated solid-phase extraction device, is specifically related to a kind of comprehensive solid-phase extraction device.
Background technology
Modern analytical technique develops towards quick, trace, trace, polycomponent and highly selective direction, and various novel precise instrument emerges in an endless stream, and sample pretreatment process it is also proposed more and more higher requirement. But, the 60% of analysis operation time is even mostly is be used in the pre-treatment of sample, and testing error is also most of from sample pretreatment process. Solid-Phase Extraction (SPE) is a kind of effective trace and trace substance isolation of purified means. When using cylindricality solid-phase extraction device, generally the step such as the sorption extraction of activated, sample and wash-out by determinand wash-out and is collected in the organic solvent of minimum volume (several milliliters), then concentrates to more small volume for analyzing with nitrogen stripping. Relative to tradition solution extraction method, Solid-Phase Extraction consumption of organic solvent reduces to some extent. Solid-Phase Extraction instrument used and device generally comprise solid-phase extraction column and solid-phase extraction device, solid-phase extraction column is normally filled with cylindricality or the pan of micron particles sorbent material, solid-phase extraction device generally adopts suction type mode of operation, also needs to be furnished with the auxiliary parts such as vacuum pump, blow-dry device, inertia gas source, high volume sampler and surge flask except being equipped with the main element of ability negative pressure. The sample that conventional solid-phase extracting instrument once can process is less, regulates solid-phase extraction column inconvenient, and some parts easily damages, and only has enrichment function, and its price is also higher. Therefore, it is necessary to it is simple and have the comprehensive solid-phase extraction device of multiple function to develop a kind of economical and practical, structure.
Summary of the invention
It is simple, economical and practical and have the comprehensive solid-phase extraction device of multiple function that the technical problem that the present invention solves there is provided a kind of structure.
The present invention adopts following technical scheme for solving the problems of the technologies described above, a kind of comprehensive solid-phase extraction device, it is characterized in that comprising vertical plate and the solid-phase extraction column baffle plate being fixed between vertical plate and heart bottle stopper plate, wherein solid-phase extraction column baffle plate is arranged at the top of vertical plate, the side of solid-phase extraction column baffle plate is provided with intensive through hole, another side of solid-phase extraction column baffle plate is provided with decentralized through hole, this intensity through hole and decentralized through hole are respectively used to place solid-phase extraction column, the both sides of the edge place relative with vertical plate, solid-phase extraction column baffle plate top is respectively equipped with baffle plate, this baffle plate and vertical plate form rubber pipe clamp groove, the other both sides of the edge place on solid-phase extraction column baffle plate top is respectively equipped with rubber hose pickup groove, the vertical plate of both sides is respectively equipped with the opening relative with rubber hose pickup groove, rubber hose is fixed in rubber pipe clamp groove and rubber hose pickup groove, this rubber hose is provided with the connection hole of opening upwards, one end of rubber hose is by the sealing of corrosion-resistant tetrafluoroethylene plug, the other end of rubber hose is connected through the opening on vertical plate with the fluid inlet of Erlenmeyer flask, the bleeding point of this Erlenmeyer flask is connected with vacuum pump, heart bottle stopper plate is arranged at the lower section of decentralized through hole, heart bottle stopper plate is provided with the heart bottle putting hole relative with decentralized through hole, this heart bottle putting hole is for placing heart bottle, the inner side of heart bottle stopper plate is provided with the storage bottle relative with intensive through hole.
The comprehensive solid-phase extraction device of the present invention both can process single sample, the batch processing of sample can also be realized, easy to use, with low cost, safety and environmental protection, and can carry out activating, enrichment and wash-out, complete most of step of Solid-Phase Extraction, eliminate the link that some are loaded down with trivial details, save manpower and space, it is to increase working efficiency.
Accompanying drawing explanation
Fig. 1 is the structural representation of the present invention.
In figure: 1, vertical plate, 2, solid-phase extraction column baffle plate, 3, heart bottle stopper plate, 4, intensive through hole, 5, decentralized through hole, 6, solid-phase extraction column, 7, baffle plate, 8, rubber hose pickup groove, 9, rubber hose, 10, hole is connected, 11, tetrafluoroethylene plug, 12, heart bottle putting hole, 13, heart bottle.
Embodiment
Being described in further details by the foregoing of the present invention by the following examples, but this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on foregoing of the present invention all belong to the scope of the present invention.
A kind of comprehensive solid-phase extraction device, comprise vertical plate 1 and the solid-phase extraction column baffle plate 2 being fixed between vertical plate 1 and heart bottle stopper plate 3, wherein solid-phase extraction column baffle plate 2 is arranged at the top of vertical plate 1, the side of solid-phase extraction column baffle plate 2 is provided with intensive through hole 4, another side of solid-phase extraction column baffle plate 2 is provided with decentralized through hole 5, this intensity through hole 4 and decentralized through hole 5 are respectively used to place solid-phase extraction column 6, the both sides of the edge place relative with vertical plate 1, solid-phase extraction column baffle plate 2 top is respectively equipped with baffle plate 7, this baffle plate 7 forms rubber pipe clamp groove with vertical plate 1, the other both sides of the edge place on solid-phase extraction column baffle plate 2 top is respectively equipped with rubber hose pickup groove 8, the vertical plate 1 of both sides is respectively equipped with the opening relative with rubber hose pickup groove 8, rubber hose 9 is fixed in rubber pipe clamp groove and rubber hose pickup groove 8, this rubber hose 9 is provided with the connection hole 10 of opening upwards, one end of rubber hose 9 is sealed by corrosion-resistant tetrafluoroethylene plug 11, the other end of rubber hose 9 is connected through the opening on vertical plate 1 with the fluid inlet of Erlenmeyer flask, the bleeding point of this Erlenmeyer flask is connected with vacuum pump, heart bottle stopper plate 3 is arranged at the lower section of decentralized through hole 5, heart bottle stopper plate 3 is provided with the heart bottle putting hole 12 relative with decentralized through hole 5, this heart bottle putting hole 12 is for placing heart bottle 13, the inner side of heart bottle stopper plate 3 is provided with the storage bottle relative with intensive through hole 4.
Embodiment 1
1, activate: solid-phase extraction column is inserted in the intensive through hole of solid-phase extraction column baffle plate, storage bottle is placed in the lower section of closed type through hole, joining in solid-phase extraction column by activation solution again, liquid to be activated pours waste liquid into waste liquid barrel after all flowing out, and this process is batch operation;
2, post is crossed: being inserted by Solid-Phase Extraction column sealing in the connection hole of rubber hose, be connected to by sample solution in the solid-phase extraction column activated, open vacuum pump and bleed, when sample solution flows through solid-phase extraction column, target compound is adsorbed on filler;
3, wash-out: the heart bottle collecting elutriant is positioned in heart bottle putting hole, again nitrogen is blown in the decentralized through hole of dry solid-phase extraction column insertion solid-phase extraction column baffle plate, then elutriant is joined in solid-phase extraction column, after wash-out completes, directly get elutriant carry out detecting or concentrated detection further.
Embodiment above describes the ultimate principle of the present invention, main feature and advantage; the technician of the industry should understand; the present invention is not restricted to the described embodiments; the principle that the present invention is just described described in above-described embodiment and specification sheets; under the scope not departing from the principle of the invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the scope of protection of the invention.
Claims (2)
1. a comprehensive solid-phase extraction device, it is characterized in that comprising vertical plate and the solid-phase extraction column baffle plate being fixed between vertical plate and heart bottle stopper plate, wherein solid-phase extraction column baffle plate is arranged at the top of vertical plate, the side of solid-phase extraction column baffle plate is provided with intensive through hole, another side of solid-phase extraction column baffle plate is provided with decentralized through hole, this intensity through hole and decentralized through hole are respectively used to place solid-phase extraction column, the both sides of the edge place relative with vertical plate, solid-phase extraction column baffle plate top is respectively equipped with baffle plate, this baffle plate and vertical plate form rubber pipe clamp groove, the other both sides of the edge place on solid-phase extraction column baffle plate top is respectively equipped with rubber hose pickup groove, the vertical plate of both sides is respectively equipped with the opening relative with rubber hose pickup groove, rubber hose is fixed in rubber pipe clamp groove and rubber hose pickup groove, this rubber hose is provided with the connection hole of opening upwards, one end of rubber hose is by the sealing of corrosion-resistant tetrafluoroethylene plug, the other end of rubber hose is connected through the opening on vertical plate with the fluid inlet of Erlenmeyer flask, the bleeding point of this Erlenmeyer flask is connected with vacuum pump, heart bottle stopper plate is arranged at the lower section of decentralized through hole, heart bottle stopper plate is provided with the heart bottle putting hole relative with decentralized through hole, this heart bottle putting hole is for placing heart bottle, the inner side of heart bottle stopper plate is provided with the storage bottle relative with intensive through hole.
2. the using method of a comprehensive solid-phase extraction device according to claim 1, it is characterized in that concrete steps are: (1) activates, solid-phase extraction column is inserted in the intensive through hole of solid-phase extraction column baffle plate, storage bottle is placed in the lower section of closed type through hole, again activation solution is joined in solid-phase extraction column, liquid to be activated pours waste liquid into waste liquid barrel after all flowing out, and this process is batch operation; (2) crossing post, inserted by Solid-Phase Extraction column sealing in the connection hole of rubber hose, extracting sample solution joins in the solid-phase extraction column activated, and opens vacuum pump and bleeds, and when sample solution flows through solid-phase extraction column, target compound is adsorbed on filler; (3) wash-out, the heart bottle collecting elutriant is positioned in heart bottle putting hole, again nitrogen is blown in the decentralized through hole of dry solid-phase extraction column insertion solid-phase extraction column baffle plate, then elutriant is joined in solid-phase extraction column, after wash-out completes, directly get elutriant carry out detecting or concentrated detection further.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610160323.6A CN105641971B (en) | 2016-03-21 | 2016-03-21 | A kind of comprehensive solid-phase extraction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610160323.6A CN105641971B (en) | 2016-03-21 | 2016-03-21 | A kind of comprehensive solid-phase extraction device |
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| Publication Number | Publication Date |
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| CN105641971A true CN105641971A (en) | 2016-06-08 |
| CN105641971B CN105641971B (en) | 2018-05-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610160323.6A Expired - Fee Related CN105641971B (en) | 2016-03-21 | 2016-03-21 | A kind of comprehensive solid-phase extraction device |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191584A (en) * | 2013-04-26 | 2013-07-10 | 苏州东奇生物科技有限公司 | Portable solid phase extracting device |
| CN203315794U (en) * | 2013-06-18 | 2013-12-04 | 宁波检验检疫科学技术研究院 | Novel solid phase extraction device |
| CN203634858U (en) * | 2013-12-18 | 2014-06-11 | 何孟强 | Multi-column solid-phase extraction device |
| CN204543641U (en) * | 2015-02-03 | 2015-08-12 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Simple solid phase extraction device |
| CN105709458A (en) * | 2016-02-03 | 2016-06-29 | 山东交通学院 | Experimental device for conducting solid-phase extraction on blood sample |
-
2016
- 2016-03-21 CN CN201610160323.6A patent/CN105641971B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191584A (en) * | 2013-04-26 | 2013-07-10 | 苏州东奇生物科技有限公司 | Portable solid phase extracting device |
| CN203315794U (en) * | 2013-06-18 | 2013-12-04 | 宁波检验检疫科学技术研究院 | Novel solid phase extraction device |
| CN203634858U (en) * | 2013-12-18 | 2014-06-11 | 何孟强 | Multi-column solid-phase extraction device |
| CN204543641U (en) * | 2015-02-03 | 2015-08-12 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Simple solid phase extraction device |
| CN105709458A (en) * | 2016-02-03 | 2016-06-29 | 山东交通学院 | Experimental device for conducting solid-phase extraction on blood sample |
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| CN105641971B (en) | 2018-05-01 |
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Granted publication date: 20180501 Termination date: 20190321 |