CN105688721B - For generating the micro-fluidic chip of spherical microbubble - Google Patents

For generating the micro-fluidic chip of spherical microbubble Download PDF

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Publication number
CN105688721B
CN105688721B CN201610002404.3A CN201610002404A CN105688721B CN 105688721 B CN105688721 B CN 105688721B CN 201610002404 A CN201610002404 A CN 201610002404A CN 105688721 B CN105688721 B CN 105688721B
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microbubble
chip
microchannel
micro
gas
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CN105688721A (en
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包福兵
项素娟
凃程旭
林建忠
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China Jiliang University
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China Jiliang University
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3034—Micromixers using induced convection or movement in the mixture to mix or move the fluids without mechanical means, e.g. thermodynamic instability, strong gradients, etc.
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae
    • B01F33/30121—Interdigital streams, e.g. lamellae the interdigital streams being concentric lamellae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3022—Micromixers the materials to be mixed flowing in the form of droplets the components being formed by independent droplets which are alternated, the mixing of the components being achieved by diffusion between droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Abstract

The invention discloses a kind of micro-fluidic chip for being used to generate spherical microbubble.The present invention is formed by the different chip bonding of MCA in two panels, and the bonding face of two panels chip etches the microchannel of certain thickness and width using optical etching technology.Wherein there are two fluid microchannels in the first chip, a gas microchannel, microbubble generate passage and microbubble output channel, and two fluid microchannels and gas microchannel intersection have the angle of certain angle；Have in second chip with the first chip structure size identical fluid microchannels, gas microchannel and microbubble output channel, but without microbubble generation microchannel.After two panels chip bonding forms, while liquids and gases are injected into microchannel, by adjusting fluid flow, control gas pressure intensity, generate the microbubble of different-diameter size.The present invention breaches limitation of the microbubble of microfiuidic elements generation in terms of planform.

Description

For generating the micro-fluidic chip of spherical microbubble
Technical field
The present invention relates to a kind of micro-fluidic chip, more particularly to a kind of micro-fluidic core for generating spherical micron dimension bubble Piece, belong to field of fluid machinery.
Background technology
In recent years, the unique fluid mechanical characteristic and scale effect that micron dimension bubble has by it, medical science, oil, The fields such as environment, mining, chemical industry, power, metallurgy, nuclear energy are applied widely.It is various to be based on especially in biomedical sector Ultrasonic measurement technology, targeted drug delivery and the gene mediated treatment technology of microbubble are developed rapidly.Micro- gas of generation Bubble size, stability etc. can all influence its effect in every field application.Therefore, further investigate microbubble formation mechenism and Flow behavior, theoretical foundation of the microbubble in multi-field practical application can be established.
With further investigation of the domestic and foreign scholars to microbubble, there is increasing microbubble technology of preparing, such as：Together Axle electrostatic atomization method, ultrasonic cavitation method, emulsion process, freeze-drying, atomization, high pressure homogenization method, interfacial polymerization and miniflow Element method etc..Microfiuidic elements method namely prepares microbubble using micro-fluidic chip, is the new mode of comparison, and this mode can be with By being accurately controlled liquid and gas so as to control the structure of bubble, composition and size, due to each bubble of preparation Mode is almost consistent, it is ensured that the size and polydispersity of microbubble.
But during using micro-fluidic chip preparation micron dimension bubble, due to microchannel in existing micro-fluidic chip The limitation of structure, in experimentation by control liquid and gas obtain microbubble process it is veryer long and cumbersome, be not easy Operation, and the microbubble generated is flat and non-cubic spherical microbubble.And spherical microbubble is more suitable for microbubble flowing The further research and analysis of characteristic and movement mechanism.Therefore, for the deficiency of existing micro-fluidic chip internal channel structure.
The content of the invention
The purpose of the present invention is for the deficiency during existing micro-fluidic chip generation microbubble, there is provided a kind of new Micro-fluidic chip.The micro-fluidic chip is improved to microchannel in chip, and design is re-started to the structure of microchannel, is changed The size of passage each several part.Thus reaching in experimentation can be generated than existing smaller micron amount by simple operations The purpose of the spherical microbubble of level.
In order to realize foregoing invention purpose, the technical solution adopted by the present invention is：It is a kind of to be used to generate spherical microbubble Micro-fluidic chip.Micro-fluidic chip is integrally formed by the different chip bonding of MCA in two panels, the bonding of two panels chip Face etches the microchannel of certain thickness and width using optical etching technology.Wherein there are two liquid micro- logical in the first chip Road, a gas microchannel, microbubble generation passage and microbubble output channel, two fluid microchannels and gas microchannel are handed over The angle of certain angle at boundary be present；Have in second chip micro- with the first chip structure size identical fluid microchannels, gas Passage and microbubble output channel, but without microbubble generation microchannel.After two panels chip bonding forms, while into microchannel Liquids and gases are injected, by adjusting fluid flow, control gas pressure intensity, can using the liquid of gas with various or different viscosities To generate the microbubble of different-diameter size.
Furtherly, the long 40mm of micro-fluidic chip, wide 20mm, two fluid microchannels sizes are identical in every chip, liquid Body microchannel is wide 30 μm；Gas microchannel is wide 40 μm, and microbubble output channel is wide 100 μm, and fluid microchannels, gas microchannel are carved It is 20 μm to lose depth, 40 μm of microbubble output channel etching depth, microbubble 10 μm of channel width of generation, 10 μm of etching depth； Microbubble generation channel etch identical is wide and depth forms square face, the folder between fluid microchannels and gas microchannel Angle is 70 °.
The present invention compared with prior art, has an advantageous effect in that：
1st, the structure of microchannel is one side etching in existing micro-fluidic chip, and the microbubble of generation is round pie two-dimensional gas Bubble.The present invention proposes that micro-fluidic chip is formed by the first chip and the second chip bonding of different MCAs, liquid in chip Body passage, gas passage, microbubble generate passage and width, the etching depth of microbubble output channel are different, especially It is that microbubble generation passage is etched with the first chip, wide 10 μm, 10 μm of depth, side, sectional microbubble generation passage is one The section of square；Second chip does not etch microbubble generation passage, and the width depth equidimension of other passages is and chip One is identical.Interior MCA can generate three-dimensional spherical micron dimension microbubble with the micro-fluidic chip after size-modify, break through Limitation of the microbubble of microfiuidic elements generation in terms of planform.
2nd, the disadvantage brought for the vertical stratification between existing fluid microchannels and gas microchannel in experimentation End, proposes for the angle between fluid microchannels and gas microchannel to be changed to the improvement of 70 ° of angles.Microbubble generates experimentation In, liquid phase is flowed out by both sides, the effect that folder stream focuses on is produced to gas, gas phase is by the symmetrical shearing masterpiece from both sides liquid phase With broken generation bubble, the MCA after improvement compares original structure, and the generating process of microbubble is more stable, raw Controlled range into microbubble size is wider, can generate the microbubble that diameter is less than gas microchannel size.
3rd, the structure of the invention by changing microchannel in micro-fluidic chip, adjusts microchannel each several part difference size, adopts With in experimentation of the micro-fluidic chip for generating micron dimension microbubble, operation is easier, and the micro- gas generated Bulb diameter controlled range is bigger, can generate the microbubble of smaller diameter, about 20 μm of minimum diameter.The microbubble of generation is three-dimensional ball Shape bubble, spherical microbubble are more suitable for the further research of microbubble movement mechanism and flow behavior.
Brief description of the drawings
Fig. 1 is the first chip schematic top plan view in micro-fluidic chip；
Fig. 2 is the second chip schematic top plan view in micro-fluidic chip；
Fig. 3 is micro-fluidic chip side sectional view；
In figure：1st, liquid injection channel, 2 gas injection channels, 3, liquid injection channel, 4 microbubbles generation passage, 5, micro- Bubble output channel, the 6, first chip, the 7, second chip.
Embodiment
As Figure 1-3, using PDMS be the micro-fluidic chip that is made of material as example, specific embodiment party of the invention Case is：
Micro-fluidic chip, cuboid, long 40mm, wide 20mm, high 5mm, it is bonded and is formed by the first chip 6 and the second chip 7, Chip surface etches microchannel using optical etching technology, and the first chip includes liquid injection channel 1,3, and 30 μm of channel width is deep 20 μm of degree, gas injection channel 2,40 μm of channel width, 20 μm of depth, liquid injection channel 1,3 and the intersection of gas injection channel 2 Oblique angle design, angle are 70 °, microbubble generation passage 4,40 μm of passage length, 10 μm of channel width, 10 μm of depth, microbubble generation Passage side, sectional may make up the square that the length of side is 10 μm, microbubble output channel 5,100 μm of channel width, 40 μm of depth.The Two chip fluid passages, gas passage and microbubble output channel and the first chip structure size all same, do not etch first Microbubble generation passage 4 in chip.The micro-fluidic chip formed by the first chip and the second chip bonding, microbubble generation are logical Road section is square structure, and liquid, gas passage are different with the depth of microbubble generation output channel, can generate the ball of solid Shape microbubble.The improvement of fluid passage and gas passage intersection angle makes generation microbubble operation in experimentation simpler Quickly.
When the micro-fluidic chip being made using PDMS carries out microbubble generation experiment, because PDMS materials have bullet Property, and PDMS micro-fluidic chips are firmly bonded together for two layers up and down.Therefore only needed the flat of outfit before use In the insertion chip of scalp acupuncture head gently, the other end of syringe needle is connected with plastic flexible pipe.Then, injector for medical purpose low flow velocity is passed through It is lower that alcohol flushing microchannel is injected into chip, deionized water rinsing microchannel is used again after rinsing a few minutes, to micro- after a few minutes Passage is passed through air, fluid in chip is expelled from coming, hereafter PDMS chips are in stand-by state.
In experimentation, the plastic flexible pipe being connected with liquid injection channel 1,3 is connected with injector for medical purpose, medical injection 5ml deionized water is filled in device, two injector for medical purpose are installed on precise injection pump, with syringe pump promote syringe to Liquid is injected with a firm discharge in fluid passage, filled with the plastic flexible pipe being connected and the injector for medical purpose of gas injection channel 2 It is placed on another precise injection pump, 5ml air is filled in injector for medical purpose, gas flow is set, with syringe pump propelling gas. In chip other end microbubble output channel insertion tack syringe needle connection plastic flexible pipe access microbubble reception device.Micro-fluidic core Piece is positioned under inverted microscope, it is observed that the process of microbubble generation.Difference can be recorded using high-speed camera Different shape in moment microbubble generating process.Meanwhile in experiment, different fluid flow and gas flow can be adjusted, Using the liquid of different viscosities, such as silicone oil, liquid wax, or different gas is used, such as nitrogen, microbubble can be controlled Speed, the microbubble quantity and size of generation of generation.The size that micro-fluidic chip of the present invention is related to is smaller, can produce The spherical microbubble of raw about 20 μm of diameter.
To sum up, the present invention microchannel in chip is designed and improved, make experimentation simple to operation, generation it is micro- Bubble diameter is smaller and spherical for solid
It is described above, only it is presently preferred embodiments of the present invention, not the present invention is imposed any restrictions, it is every according to the present invention Any simple modification, change and the equivalent structure change that technical spirit is made to above example, still fall within skill of the present invention In the protection domain of art scheme.

Claims (2)

1. the micro-fluidic chip for generating spherical microbubble, it is characterised in that：Micro-fluidic chip is overall by microchannel in two panels The different chip bonding of structure forms, and the bonding face of two panels chip etches certain thickness and width using optical etching technology Microchannel；Wherein there are two fluid microchannels in the first chip, a gas microchannel, microbubble generation passage and microbubble are defeated Go out passage, two fluid microchannels and gas microchannel intersection have the angle of certain angle；Have in second chip and first Chip structure size identical fluid microchannels, gas microchannel and microbubble output channel, but it is micro- logical without microbubble generation Road；After two panels chip bonding forms, while liquids and gases are injected into microchannel, by adjusting fluid flow, control gas Pressure, the microbubble of different-diameter size can be generated using the liquid of gas with various or different viscosities.
2. the micro-fluidic chip according to claim 1 for being used to generate spherical microbubble, it is characterised in that：Micro-fluidic chip Long 40mm, wide 20mm, two fluid microchannels sizes are identical in every chip, and fluid microchannels are wide 30 μm；Gas microchannel is wide 40 μm, microbubble output channel is wide 100 μm, and fluid microchannels, gas microchannel etching depth are 20 μm, and microbubble output is logical 40 μm of road etching depth, microbubble 10 μm of channel width of generation, 10 μm of etching depth；Microbubble generation channel etch identical it is wide and Depth forms the face of square, and the angle between fluid microchannels and gas microchannel is 70 °.
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CN109833921B (en) * 2017-11-28 2021-06-11 中国科学院大连化学物理研究所 Preparation method of high-flux controllable double-aqueous-phase liquid drop based on microfluidic technology
CN109030368B (en) * 2018-09-08 2023-06-23 重庆科技学院 Use method of microfluidic chip combined with cuvette
CN109701430A (en) * 2019-01-21 2019-05-03 中国计量大学 A method of vibration pipeline control T-type micro-fluidic chip generates microbubble
CN111686665A (en) * 2019-03-15 2020-09-22 南京延长反应技术研究院有限公司 Micro-interface enhanced reaction system
CN112169720A (en) * 2019-07-04 2021-01-05 南京延长反应技术研究院有限公司 Nano-micro interface enhanced reaction system
CN110387313B (en) * 2019-08-07 2022-09-02 哈尔滨工业大学 Magnetophoretic microfluidic chip based on bubble mixing
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