CN105686811B - A kind of minimal removed of intracranial parameter detecting probe - Google Patents

A kind of minimal removed of intracranial parameter detecting probe Download PDF

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Publication number
CN105686811B
CN105686811B CN201610100812.2A CN201610100812A CN105686811B CN 105686811 B CN105686811 B CN 105686811B CN 201610100812 A CN201610100812 A CN 201610100812A CN 105686811 B CN105686811 B CN 105686811B
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China
Prior art keywords
stiff case
optical fiber
parameter detecting
detecting probe
intracranial
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CN201610100812.2A
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CN105686811A (en
Inventor
李韪韬
张言
钱诚
钱志余
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Nanjing University of Aeronautics and Astronautics
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Nanjing University of Aeronautics and Astronautics
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/01Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/03Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
    • A61B5/031Intracranial pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04Constructional details of apparatus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0247Pressure sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0271Thermal or temperature sensors

Abstract

A kind of minimal removed of intracranial parameter detecting probe, comprising: the contact probe head positioned at front end, the contact probe head include a stiff case, the cavity worn for optic module are equipped with inside the stiff case, end is equipped with annular groove;Optic module includes optical fiber and the annular leather plug for being fixed on optical fiber one end, and one end of the non-collar-shaped leather plug of optic module is penetrated from the front end of stiff case, until annular leather plug is completely into the front end contact probe head contact in annular groove, forming complete seal;The first notch is offered in the side wall of the stiff case, is provided with pressure sensor in first notch;The rear end of the stiff case is arranged in medical gels hose, for wrapping up signal wire conduit inside stiff case and optical fiber and the processing module for connecting rear end.The present invention provides a kind of minimal removed of intracranial parameter detecting probe, is used for real-time monitoring encephalic multi-parameter index.

Description

A kind of minimal removed of intracranial parameter detecting probe
Technical field
The invention belongs to Implanted medical system field more particularly to a kind of minimal removed of intracranial parameter detecting probes.
Background technique
In Characters of traumatic brain injury (Traumatic Brain Injury, TBI) patient, there is 20% can leave sequelae, This group of human bodies can be influenced by sequelae for a long time in life afterwards, create a large amount of manpower, material resources and financial resources waste. Study carefully the reason of it is wherein damaged to include Falling Injury, have a fist fight with traffic accident etc..Patients with cerebral injury is often secondary traumatic brain Oedema (Traumatic Brain Edema, TBE) or intracranial hematoma, increase, cerebral blood flow (CBF) to will cause intracranial pressure (ICP) Decline aggravates cerebral injury and causes patient dead.Clinically, the main monitoring index of traumatic brain edema is ICP and CBF.? There is urgent problem to be solved in the Clinics and Practices of traumatic brain edema: lacking a kind of effective multi-parameter monitoring technology;Lack one Kind is directed to the curative effect evaluation model of individual difference;Lack a kind of curative effect comprehensive assessment factor associated with pathologic basis.
Intracranial pressure (Intracranial Pressure, ICP) is to influence one of the principal element of cerebral blood flow (CBF), intracranial pressure Measurement to confirm or exclude increased intracranial pressure, and determine cerebral perfusion pressure it is very necessary, this is also contributed to head trauma injury Person carries out guiding treatment.There is a large amount of evidence to support that, using monitoring intracranial pressure, ICP monitoring has been developed as one very Useful tool, and have become the core to serious cerebral injury patient's Intensive Care Therapy management.
Encephalic temperature (Intracranial Temperature, ICT) and intracranial pressure have certain relevance, meanwhile, Clinically think the variation often variation earlier than ICP of ICT.In Mild Hypothermal Cerebral protection severe traumatic patients with sevious craniocerebral injury In operation, the treatment of ICT is particularly important.
In neurosurgery, local blood oxygen saturation (rSO2) index has weight for evaluation brain oxygen metabolism and prognosis The meaning wanted.By the measurement of brain part blood oxygen saturation, the complication of neurological disease, and predictable neural function can be found in time The generation of energy obstacle.
Currently, clinically lacking while having the instrument of ICP/ICT/rSO2 integration test function, so that in neurosurgery In operation, doctor using subjective and experience come the case where judging patient, can not scientific and effective guided operation, evaluation treatment effect It is undesirable to frequently result in therapeutic effect for fruit.
Meanwhile in neurosurgery, due to lacking many kinds of parameters measuring system, limited parameter is lacked Evaluation method, also none standardized data acquisition and storage specification.In the whole country, it is huge to seem neurosurgery amount Greatly, a series of data are acquired, but lack unified storage standard, the analysis and identification of Future Data can not be carried out.
For this purpose, developing a kind of Data Collective of Parameters instrument in field of neurosurgery urgent need, pass through clinical and underlying diseases Sort research and multi-parameters sampling establish clinical use codes and standards, realize clinical, basic research effective combination and breakthrough.
Summary of the invention
It is an object of the invention to provide a kind of minimal removed of intracranial parameter detecting probe according to above-mentioned status, for real-time Monitor encephalic multi-parameter index.
To achieve the above object, the present invention adopts the following technical scheme:
A kind of minimal removed of intracranial parameter detecting probe, comprising:
Contact probe head positioned at front end, the contact probe head include a stiff case, are equipped with and supply inside the stiff case The cavity that optic module is worn, end are equipped with annular groove;Optic module includes optical fiber and the annular skin for being fixed on optical fiber one end Plug, one end of the non-collar-shaped leather plug of optic module are penetrated from the front end of stiff case, until annular leather plug is recessed completely into annular In slot, the front end contact probe head contact of complete seal is formed;
The first notch is offered on the side side wall of the stiff case, is provided with pressure sensing in first notch Device;
The rear end of the stiff case is arranged in medical gels hose, leads for wrapping up the signal wire inside stiff case Pipe and optical fiber and the processing module for connecting rear end.
Pre-buried temperature sensor in the stiff case, the temperature sensor pass through the processing module of signal wire and rear end Connection.
The rear portion of the stiff case is equipped with the cavity for grafting medical gels hose, and stiff case, which is equipped with, is used for point Second notch of glue, one end of the medical gels hose are interspersed in first in the cavity of stiff case rear end, then by second Notch carries out dispensing and mutually fixes with stiff case.
Airway is equipped in the medical gels hose.
The temperature sensor is thermistor.
The optical fiber is made of two 100 μm of single mode optical fiber, wherein a connection light source, another connection Photoelectric Detection Device.
The light source uses dual wavelength.
The stiff case is the titanium alloy shell that length is 5mm ~ 10mm length.
The titanium alloy shell is an integral molding structure.
Beneficial effects of the present invention:
The first, described front end titanium alloy shell is integrated with pressure sensor, temperature sensor, local blood oxygen saturation light Fibre can be realized measurement while to encephalic multi-physiological-parameter.
The second, described titanium alloy shell shell can guarantee internal other chips in addition to pressure sensor not by outer The influence of portion's mechanical stress.
Possess fluting in third, the titanium alloy shell, totally three, two of them are located at the upper end of shell, a position In the front end of shell.In two of upper end, one is used for placement force sensor, and medical adhesive convenient to use draws chip Foot is physically separated, and without interfering the measurement to intracranial pressure, simplifies welding procedure.
4th, the light source connecting with optical fiber at the same time, connects the another of photoelectric detection system using dual wavelength The light of dual wavelength is also collected, conducted to root optical fiber.The use of optical fiber can conduct the optical superposition of different wave length together, and lead to The algorithm of post-mature and calibration can measure the brain part blood oxygen saturation for obtaining fibre-optical probe position.
Detailed description of the invention
Fig. 1 is the schematic diagram that optic module in encephalic multi-parameter of the present invention probe respectively forms the state that is partially separated.
Fig. 2 is the schematic diagram of the optic module assembled state in encephalic multi-parameter probe of the present invention.
Fig. 3 is the schematic diagram that encephalic multi-parameter probe of the present invention detaches remaining module after optic module.
Fig. 4 is each component part of encephalic multi-parameter probe of the present invention, is assembled into the process schematic completely popped one's head in.
Fig. 5 is the complete diagram of encephalic multi-parameter probe of the present invention.
Fig. 6 is the cross-sectional view on encephalic multi-parameter probe A-direction A of the present invention.
Fig. 7 is the structure size schematic diagram of encephalic multi-parameter probe complete diagram of the present invention.
Wherein: the bis- optical fiber of 1- and its envelope;2- annular leather plug;The first notch of 3-;4- pressure sensor;5- temperature sensing Device;6- airway;7- annular groove;8- colloid hose;9- signal wire and its envelope;10- stiff case;The second slot of 11- Mouthful.
Specific embodiment
By specific embodiment with reference to the accompanying drawings, the present invention is described in further detail below.
As depicted in figs. 1 and 2, the present invention receives access using double transmissions of the optical fiber as near infrared light.And by double optical fiber It is packaged in its envelope, is convenient for subsequent threading technique.One end cap of double optical fiber and its envelope is gone forward side by side in annular leather plug Row is fixed.
As shown in figure 3, the bright side view for removing every other component part except optic module of the chart.
As shown in figure 4, one end of the non-collar-shaped leather plug of optic module is penetrated from the front end of titanium alloy shell.
As shown in figure 5, continue it is above-mentioned penetrate operation, until annular leather plug and annular groove 7 completely attach to, formed completely close The front end contact probe head contact of envelope.
Optic module is contacted by threading technique and stiff case perfection, forms the probe contacts of the front end of sealing.
Pressure sensor 4 is placed in the first notch of stiff case, and this grooving processes are effectively avoided due to pressure The evagination of sensor causes the mechanical damage to intracranial tissue.The pressure sensor, can using the welding procedure for formula of sinking simultaneously It is physically separated with the pin to the sensor, relieves the unnecessary safety such as short circuit as caused by pin sealing problem Property misgivings.The sensor is connected by three signal wires and the processing circuit of rear end, and signal circuit is included in signal wire conduit 9 In.
Temperature sensor 5 is placed in the inside of titanium alloy shell, which follows stiff case contact to be implanted to brain group When knitting, encephalic temperature can be measured, the signal wire of the element is included in signal wire as pressure sensor In conduit 9.
Airway 6, after through 11 dispensing of the second notch, it is easy to cause stiff case inner space and outside empty Air bound is exhausted, and the effect of the airway 6 is exactly in order to avoid this kind of situation.
Medical gels hose 8, for wrapping up signal wire conduit 9 and optic module after stiff case 10.This is medical Colloid hose 8 is interspersed in the rear end of stiff case 10 first, can be by the medical gels hose 8 after operating using dispensing It is fixed together with stiff case 10.
Signal wire conduit 9 mainly wraps up some necessary signal wires, sends it to the processing part of rear end.
Stiff case 10, the stiff case 10 are the protective device of all the sensors and optic module, hard shell It ensure that internal portions are not influenced by external force.As an optimal technical scheme of the invention, the material of the stiff case Material uses titanium alloy.
As shown in fig. 6, the figure is A-A sectional view that present invention composition is completely popped one's head in, stiff case 10 is located at outermost layer use The device in indoor portion, medical gels hose 8 are used to wrap up the conduit and optical fiber and the processing module for connecting rear end of some inside, letter Number wire conduit 9, optic module, airway 6 are located at medical gels inside hose, connect back end processing module, guarantee and rear end Space connection.

Claims (8)

1. a kind of minimal removed of intracranial parameter detecting probe characterized by comprising
Contact probe head positioned at front end, the contact probe head include a stiff case, are equipped with inside the stiff case for optical fiber The cavity that module is worn, end are equipped with annular groove;Optic module includes optical fiber and the annular leather plug for being fixed on optical fiber one end, light One end of the non-collar-shaped leather plug of fiber module is penetrated from the front end of stiff case, until annular leather plug is completely into annular groove, Form the front end contact probe head contact of complete seal;
The first notch is offered on the side side wall of the stiff case, is provided with pressure sensor in first notch;
The rear end of the stiff case is arranged in medical gels hose, for wrap up signal wire conduit inside stiff case and Optical fiber and the processing module for connecting rear end;The optical fiber is made of two 100 μm of single mode optical fiber, wherein a connection light source, Another connection photoelectric detection system, processing module obtain the brain office of fibre-optical probe position by algorithm and calibration, measurement Portion's blood oxygen saturation.
2. minimal removed of intracranial parameter detecting probe according to claim 1, which is characterized in that pre-buried in the stiff case Temperature sensor, the temperature sensor are connected by the processing module of signal wire and rear end.
3. minimal removed of intracranial parameter detecting probe according to claim 1, which is characterized in that the rear portion of the stiff case Equipped with the cavity for grafting medical gels hose, stiff case, which is equipped with, is used for the second notch for dispensing glue, and the medical gels are soft One end of pipe is interspersed in first in the cavity of stiff case rear end, then mutually solid with stiff case by carrying out dispensing to the second notch It is fixed.
4. minimal removed of intracranial parameter detecting probe according to claim 3, which is characterized in that in the medical gels hose Equipped with airway.
5. minimal removed of intracranial parameter detecting probe according to claim 2, which is characterized in that the temperature sensor is heat Quick resistance.
6. minimal removed of intracranial parameter detecting probe according to claim 1, which is characterized in that the light source uses double wave It is long.
7. minimal removed of intracranial parameter detecting probe according to claim 1, which is characterized in that the stiff case is length For the titanium alloy shell of 5mm ~ 10mm length.
8. minimal removed of intracranial parameter detecting probe according to claim 7, which is characterized in that the titanium alloy shell is one Forming structure.
CN201610100812.2A 2016-02-24 2016-02-24 A kind of minimal removed of intracranial parameter detecting probe Active CN105686811B (en)

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CN107126195A (en) * 2017-05-08 2017-09-05 长飞光纤光缆股份有限公司 A kind of insertion type probe
CN107320068B (en) * 2017-06-12 2020-10-16 长飞光纤光缆股份有限公司 Manufacturing method of interventional probe body
CN107184191A (en) * 2017-06-29 2017-09-22 长飞光纤光缆股份有限公司 A kind of miniature insertion type probe
WO2019037071A1 (en) * 2017-08-25 2019-02-28 Cheng Weyland Device and method for feedback and control using optical fibers in catheters
CN107582070B (en) * 2017-09-04 2020-06-02 长飞光纤光缆股份有限公司 Intervention type oxygen partial pressure-temperature composite probe
CN107625516A (en) * 2017-09-04 2018-01-26 长飞光纤光缆股份有限公司 A kind of insertion type medical probe of multi-parameter
CN108325089A (en) * 2018-01-03 2018-07-27 南通大学 A kind of tumour laserthermia and multi-parameters real-time monitoring probe
CN109674460A (en) * 2019-02-18 2019-04-26 中国电子科技集团公司第二十六研究所 A kind of the bougie structure and its packaging method of implanted micro sensor
CN113143231B (en) * 2021-04-19 2023-08-22 武汉理工大学 Human body invasive pressure temperature multi-parameter real-time optical fiber detection method and system

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