CN105663924A - Pharmaceutical composition for preventing or treating type-II diabetic complications and preparation method thereof - Google Patents

Pharmaceutical composition for preventing or treating type-II diabetic complications and preparation method thereof Download PDF

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CN105663924A
CN105663924A CN201610208640.0A CN201610208640A CN105663924A CN 105663924 A CN105663924 A CN 105663924A CN 201610208640 A CN201610208640 A CN 201610208640A CN 105663924 A CN105663924 A CN 105663924A
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parts
rhizoma
pharmaceutical composition
fructus
gypsum fibrosum
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/808—Scrophularia (figwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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Abstract

The invention discloses a pharmaceutical composition for preventing or treating type-II diabetic complications and a preparation method thereof. In the pharmaceutical composition for preventing or treating type-II diabetic complications, the active ingredients consist of the following active pharmaceutical ingredients in parts by weight: 20-40 parts of radix scrophulariae, 100-130 parts of rhizoma dioscoreae, 90-120 parts of radix polygonati officinalis, 80-100 parts of rhizoma coptidis, 100-130 parts of poria cocos, 95-110 parts of cuscuta chinensis, 100-135 parts of fructus mume, 95-110 parts of rhizoma atractylodis macrocephalae, 90-115 parts of herba agrimoniae, 130-155 parts of cortex lycii radicis, 100-125 parts of fructus xanthii, 50-65 parts of malt, 50-65 parts of platycodon, 50-60 parts of folium mori, 30-45 parts of herba epimedii and 280-310 parts of gypsum. Particularly compared with single administration, the pharmaceutical composition for preventing or treating type-II diabetic complications can effectively treat or relieve complications caused by diabetes, realizes unexpected technical effects on improving blood glucose and reducing the levels of blood lipid and glycated serum protein, has an exact curative effect and short onset time, and has remarkable advantages and synergistic effects.

Description

Pharmaceutical composition of prevention or treatment type Ⅱdiabetes mellitus complication and preparation method thereof
Technical field
The present invention relates to pharmaceutical composition for the treatment of type Ⅱdiabetes mellitus complication and preparation method thereof, particularly to prevention or the pharmaceutical composition treating type Ⅱdiabetes mellitus complication and preparation method thereof.
Background technology
Whole world diabetics increases year by year at present, and the diabetics number of China occupies first of the whole world, has reached 1.14 hundred million; And type Ⅱdiabetes mellitus person occupies the 90%-95% accounting for diabetics sum in the diabetic population of China. Type Ⅱdiabetes mellitus has become one of principal disease of the threat whole world or even China's national health, the carbohydrate metabolism disturbance that it is caused, causes microangiopathies, then causes a series of diabetic complication, including retinopathy, cardiovascular and cerebrovascular disease, diabetic nephropathy and diabetes foot disease etc. These diabetic complications allow patient enjoy ailing torment especially. Existing medicine mostly is folk prescription administration in blood glucose controlling, and long-term taking is relatively big to kidney burden, and for the prevention of complication and treatment, has little effect.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency existing in prior art, it is provided that the pharmaceutical composition of prevention or treatment type Ⅱdiabetes mellitus complication.
In order to realize foregoing invention purpose, the invention provides techniques below scheme:
The pharmaceutical composition of prevention or treatment type Ⅱdiabetes mellitus complication, active component is made up of the crude drug of following weight portion: Radix Scrophulariae 20-40 part, Rhizoma Dioscoreae 100-130 part, Rhizoma Polygonati Odorati 90-120 part, Rhizoma Coptidis 80-100 part, Poria 100-130 part, Semen Cuscutae 95-110 part, Fructus Mume 100-135 part, Rhizoma Atractylodis Macrocephalae 95-110 part, Herba Agrimoniae 90-115 part, Cortex Lycii 130-155 part, Fructus Xanthii 100-125 part, Fructus Hordei Germinatus 50-65 part, Radix Platycodonis 50-65 part, Folium Mori 50-60 part, Herba Epimedii 30-45 part, Gypsum Fibrosum 280-310 part.
Further, aforementioned pharmaceutical compositions, active component is preferably made up of the crude drug of following weight portion: Radix Scrophulariae 25-35 part, Rhizoma Dioscoreae 110-120 part, Rhizoma Polygonati Odorati 100-110 part, Rhizoma Coptidis 90-95 part, Poria 110-120 part, Semen Cuscutae 95-110 part, Fructus Mume 110-125 part, Rhizoma Atractylodis Macrocephalae 100-105 part, Herba Agrimoniae 100-110 part, Cortex Lycii 145-152 part, Fructus Xanthii 110-120 part, Fructus Hordei Germinatus 58-62 part, Radix Platycodonis 58-62 part, Folium Mori 55-60 part, Herba Epimedii 40-42 part, Gypsum Fibrosum 295-305 part.
Further, aforementioned pharmaceutical compositions, active component is preferably made up of the crude drug of following weight portion: Radix Scrophulariae 30 parts, Rhizoma Dioscoreae 120 parts, Rhizoma Polygonati Odorati 100 parts, Rhizoma Coptidis 90 parts, 120 parts of Poria, Semen Cuscutae 100 parts, Fructus Mume 120 parts, the Rhizoma Atractylodis Macrocephalae 100 parts, Herba Agrimoniae 100 parts, Cortex Lycii 150 parts, Fructus Xanthii 120 parts, 60 parts of Fructus Hordei Germinatus, Radix Platycodonis 60 parts, 60 parts of Folium Mori, Herba Epimedii 40 parts, Gypsum Fibrosum 300 parts.
Second purpose of the present invention is in that the preparation method providing aforementioned pharmaceutical compositions. The preparation method of the pharmaceutical composition of prevention or treatment type Ⅱdiabetes mellitus complication, comprises the following steps:
(1) take Radix Scrophulariae, Rhizoma Dioscoreae and Gypsum Fibrosum 90-110 part and beat as fine powder, excessively 90-100 mesh sieve;
(2) take remaining components and add the soak by water three times of 5-7 times of quality, decoct 1.5-2.5 hour every time;
(3) merging filtrate, filters, concentrated filtrate, is concentrated into relative density and is 1.06-1.25(90 DEG C) thick paste;
(4) thick paste that fine powder step (1) obtained obtains with step (3) is mixed homogeneously;
(5) dry, pulverize, encapsulated, make 1000.
Compared with prior art, beneficial effects of the present invention: the pharmaceutical composition of present invention prevention or treatment type Ⅱdiabetes mellitus complication, compared with being particularly administered with folk prescription, can effectively treat or complication that diabetes-alleviating causes, beyond thought technique effect is achieved in improving blood glucose, reduction blood fat and glycated serum protein and be horizontal, determined curative effect, onset time is short, has significant advantage, and has synergism.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail. But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to below example, and all technology realized based on present invention belong to the scope of the present invention.
Embodiment 1 is prevented or the pharmaceutical composition treating type Ⅱdiabetes mellitus complication and preparation method thereof
The pharmaceutical composition of prevention or treatment type Ⅱdiabetes mellitus complication, active component is made up of the crude drug of following weight portion:
Radix Scrophulariae 30 parts, Rhizoma Dioscoreae 120 parts, Rhizoma Polygonati Odorati 100 parts, Rhizoma Coptidis 90 parts, 120 parts of Poria, Semen Cuscutae 100 parts, Fructus Mume 120 parts, the Rhizoma Atractylodis Macrocephalae 100 parts, Herba Agrimoniae 100 parts, Cortex Lycii 150 parts, Fructus Xanthii 120 parts, 60 parts of Fructus Hordei Germinatus, Radix Platycodonis 60 parts, 60 parts of Folium Mori, Herba Epimedii 40 parts, Gypsum Fibrosum 300 parts.
The preparation method of the pharmaceutical composition of the prevention of this example or treatment type Ⅱdiabetes mellitus complication, comprises the following steps:
(1) take Radix Scrophulariae, Rhizoma Dioscoreae and Gypsum Fibrosum 110 parts and beat as fine powder, excessively 100 mesh sieves;
(2) take remaining components and add the soak by water three times of 7 times of quality, decoct 2 hours every time;
(3) merging filtrate, filters, concentrated filtrate, is concentrated into relative density and is 1.20(90 DEG C) thick paste;
(4) thick paste that fine powder step (1) obtained obtains with step (3) is mixed homogeneously;
(5) dry, pulverize, encapsulated, make 1000.
Embodiment 2 is prevented or the pharmaceutical composition treating type Ⅱdiabetes mellitus complication and preparation method thereof
The pharmaceutical composition of prevention or treatment type Ⅱdiabetes mellitus complication, active component is made up of the crude drug of following weight portion:
Radix Scrophulariae 20 parts, Rhizoma Dioscoreae 100 parts, Rhizoma Polygonati Odorati 90 parts, Rhizoma Coptidis 80 parts, 100 parts of Poria, Semen Cuscutae 95 parts, Fructus Mume 100 parts, the Rhizoma Atractylodis Macrocephalae 95 parts, Herba Agrimoniae 90 parts, Cortex Lycii 130 parts, Fructus Xanthii 100 parts, 50 parts of Fructus Hordei Germinatus, Radix Platycodonis 50 parts, 50 parts of Folium Mori, Herba Epimedii 30 parts, Gypsum Fibrosum 280 parts.
The preparation method of the pharmaceutical composition of the prevention of this example or treatment type Ⅱdiabetes mellitus complication, comprises the following steps:
(1) take Radix Scrophulariae, Rhizoma Dioscoreae and Gypsum Fibrosum 90 parts and beat as fine powder, excessively 90 mesh sieves;
(2) take remaining components and add the soak by water three times of 5 times of quality, decoct 1.5 hours every time;
(3) merging filtrate, filters, concentrated filtrate, is concentrated into relative density and is 1.15(90 DEG C) thick paste;
(4) thick paste that fine powder step (1) obtained obtains with step (3) is mixed homogeneously;
(5) dry, pulverize, encapsulated, make 1000.
The pharmaceutical composition that the present embodiment obtains is capsule, and content is the little granule of light brown; Gas delicate fragrance, taste is micro-sweet; QI invigorating, yin nourishing, promote the production of body fluid, for diabetes spp deficiency of both QI and YIN person; Oral, one time 4～6,3 times on the one. Take this example compositions, incipient diabetic is had to the effect of glycemic control, diabetes for many years are had to the effect of prevention and complication, simultaneously, long-term taking this example compositions is little to kidney burden, has highly significant effect in prevention and treatment kidney disease, cardiovascular and cerebrovascular disease.
Embodiment 3 is prevented or treats the pharmaceutical composition of type Ⅱdiabetes mellitus complication
The pharmaceutical composition of prevention or treatment type Ⅱdiabetes mellitus complication, active component is made up of the crude drug of following weight portion: Radix Scrophulariae 40 parts, Rhizoma Dioscoreae 130 parts, Rhizoma Polygonati Odorati 120 parts, Rhizoma Coptidis 100 parts, 130 parts of Poria, Semen Cuscutae 110 parts, Fructus Mume 135 parts, the Rhizoma Atractylodis Macrocephalae 110 parts, Herba Agrimoniae 115 parts, Cortex Lycii 155 parts, Fructus Xanthii 125 parts, 65 parts of Fructus Hordei Germinatus, Radix Platycodonis 65 parts, 60 parts of Folium Mori, Herba Epimedii 45 parts, Gypsum Fibrosum 310 parts.
The preparation method of the pharmaceutical composition of the prevention of this example or treatment type Ⅱdiabetes mellitus complication, comprises the following steps:
(1) take Radix Scrophulariae, Rhizoma Dioscoreae and Gypsum Fibrosum 110 parts and beat as fine powder, excessively 100 mesh sieves;
(2) take remaining components and add the soak by water three times of 7 times of quality, decoct 2.5 hours every time;
(3) merging filtrate, filters, concentrated filtrate, is concentrated into relative density and is 1.25(90 DEG C) thick paste;
(4) thick paste that fine powder step (1) obtained obtains with step (3) is mixed homogeneously;
(5) dry, pulverize, encapsulated, make 1000.
Embodiment 4 is prevented or treats the pharmaceutical composition of type Ⅱdiabetes mellitus complication
The pharmaceutical composition of prevention or treatment type Ⅱdiabetes mellitus complication, active component is made up of the crude drug of following weight portion: Radix Scrophulariae 33 parts, Rhizoma Dioscoreae 126 parts, Rhizoma Polygonati Odorati 103 parts, Rhizoma Coptidis 99 parts, 122 parts of Poria, Semen Cuscutae 100 parts, Fructus Mume 110 parts, the Rhizoma Atractylodis Macrocephalae 109 parts, Herba Agrimoniae 105 parts, Cortex Lycii 140 parts, Fructus Xanthii 118 parts, 55 parts of Fructus Hordei Germinatus, Radix Platycodonis 60 parts, 58 parts of Folium Mori, Herba Epimedii 40 parts, Gypsum Fibrosum 304 parts.
(1) take Radix Scrophulariae, Rhizoma Dioscoreae and Gypsum Fibrosum 105 parts and beat as fine powder, excessively 100 mesh sieves;
(2) take remaining components and add the soak by water three times of 6 times of quality, decoct 1.5 hours every time;
(3) merging filtrate, filters, concentrated filtrate, is concentrated into relative density and is 1.06(90 DEG C) thick paste;
(4) thick paste that fine powder step (1) obtained obtains with step (3) is mixed homogeneously;
Dry, pulverize, encapsulated, make 1000.

Claims (5)

1. the pharmaceutical composition of prevention or treatment type Ⅱdiabetes mellitus complication, it is characterized in that, active component is made up of the crude drug of following weight portion: Radix Scrophulariae 20-40 part, Rhizoma Dioscoreae 100-130 part, Rhizoma Polygonati Odorati 90-120 part, Rhizoma Coptidis 80-100 part, Poria 100-130 part, Semen Cuscutae 95-110 part, Fructus Mume 100-135 part, Rhizoma Atractylodis Macrocephalae 95-110 part, Herba Agrimoniae 90-115 part, Cortex Lycii 130-155 part, Fructus Xanthii 100-125 part, Fructus Hordei Germinatus 50-65 part, Radix Platycodonis 50-65 part, Folium Mori 50-60 part, Herba Epimedii 30-45 part, Gypsum Fibrosum 280-310 part.
2. pharmaceutical composition according to claim 1, it is characterized in that, active component is made up of the crude drug of following weight portion: Radix Scrophulariae 25-35 part, Rhizoma Dioscoreae 110-120 part, Rhizoma Polygonati Odorati 100-110 part, Rhizoma Coptidis 90-95 part, Poria 110-120 part, Semen Cuscutae 95-110 part, Fructus Mume 110-125 part, Rhizoma Atractylodis Macrocephalae 100-105 part, Herba Agrimoniae 100-110 part, Cortex Lycii 145-152 part, Fructus Xanthii 110-120 part, Fructus Hordei Germinatus 58-62 part, Radix Platycodonis 58-62 part, Folium Mori 55-60 part, Herba Epimedii 40-42 part, Gypsum Fibrosum 295-305 part.
3. pharmaceutical composition according to claim 2, it is characterized in that, active component is made up of the crude drug of following weight portion: Radix Scrophulariae 30 parts, Rhizoma Dioscoreae 120 parts, Rhizoma Polygonati Odorati 100 parts, Rhizoma Coptidis 90 parts, 120 parts of Poria, Semen Cuscutae 100 parts, Fructus Mume 120 parts, the Rhizoma Atractylodis Macrocephalae 100 parts, Herba Agrimoniae 100 parts, Cortex Lycii 150 parts, Fructus Xanthii 120 parts, 60 parts of Fructus Hordei Germinatus, Radix Platycodonis 60 parts, 60 parts of Folium Mori, Herba Epimedii 40 parts, Gypsum Fibrosum 300 parts.
4. the preparation method of pharmaceutical composition of prevention described in claim 1-3 any one or treatment type Ⅱdiabetes mellitus complication, it is characterised in that comprise the following steps:
Take Radix Scrophulariae, Rhizoma Dioscoreae and Gypsum Fibrosum 90-110 part and beat as fine powder, excessively 90-100 mesh sieve;
Take remaining components and add the soak by water three times of 5-7 times of quality, decoct 1.5-2.5 hour every time;
Merging filtrate, filters, concentrated filtrate, is concentrated into relative density and is 1.06-1.25(90 DEG C) thick paste;
The thick paste that fine powder step (1) obtained obtains with step (3) is mixed homogeneously;
Dry, pulverize, encapsulated, make 1000.
5. preparation method according to claim 4, it is characterised in that the consumption of described step (1) Gypsum Fibrosum is 100 parts.
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CN106421374A (en) * 2016-12-13 2017-02-22 四川西奈生物科技有限公司 Traditional Chinese medicine composition for treating diabetes and application method thereof
CN108524766A (en) * 2018-04-11 2018-09-14 天津国际生物医药联合研究院 A kind of Chinese medicine composition and its application

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN106421374A (en) * 2016-12-13 2017-02-22 四川西奈生物科技有限公司 Traditional Chinese medicine composition for treating diabetes and application method thereof
CN108524766A (en) * 2018-04-11 2018-09-14 天津国际生物医药联合研究院 A kind of Chinese medicine composition and its application

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Application publication date: 20160615