CN103301356A - Preparation method of enema for chronic renal failure - Google Patents
Preparation method of enema for chronic renal failure Download PDFInfo
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- CN103301356A CN103301356A CN2013102715409A CN201310271540A CN103301356A CN 103301356 A CN103301356 A CN 103301356A CN 2013102715409 A CN2013102715409 A CN 2013102715409A CN 201310271540 A CN201310271540 A CN 201310271540A CN 103301356 A CN103301356 A CN 103301356A
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Abstract
The invention discloses a preparation method of an enema for chronic renal failure for solving the treatment problem of the chronic renal failure. The preparation method is characterized in that the preparation method comprises the following steps of: (1) performing reduced pressure distillation on ailanthus-like pricklyash bark, catclaw buttercup root and dried mussel coarse powder to extract volatile oil; (2) performing reduced pressure decoction on tall gastrodia tuber to obtain a filtrate; (3) performing water decoction on trikeraia hookeri, magnolia amoena, dragon's blood, melanoidin malt, scorch-fried medicated leaven, mimoselike rosewood leaf, peach gum, cassia twig and dregs obtained in the step (1) to obtain a filtrate for later use; (4) merging the filtrates obtained in the steps (2) and (3), performing reduced pressure concentration to obtain a dry extract, and crushing to obtain dry extract powder; (5) spraying the volatile oil obtained in the step (1) into the dry extract powder obtained in the step (4), uniformly mixing, and screening by a 100-mesh screen to obtain colon dialysis concentrated powder; and (6) adding ten times the volume of warm water into the colon dialysis concentrated powder obtained in the step (5) during the use, and uniformly mixing. Clinical experiments prove that by using the enema for treating the chronic renal failure, the frequency of hemodialysis can be reduced, and the preparation method is further worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of chronic renal failure enema preparation method.
Background technology
Chronic renal failure refers to that various nephropathys cause the gradual irreversibility of renal function to go down, until the clinical syndrome that the series of symptoms that afunction occurs and metabolism disorder form is called for short chronic kidney hypofunction.Be the uremia that it has often been said the whole latter stage of chronic kidney hypofunction.Uremia is not an independently disease, but the total clinical syndrome of the nephropathy in various late periods, is that chronic renal failure enters the syndrome that series of clinical manifestations that whole end occurs during the stage forms.
The autoblood dialysis apply to clinical since, make many Uraemia in telophase patients be able to long-term surviving.But hemodialysis also is faced with some problems when constantly prolonging patient's life.The one, expensive expense, the 2nd, how to improve dialysis-effect and Quality of Life.
Previously the report for the treatment of by Chinese herbs chronic renal failure intestinal canal administration is many, rush down below (Radix et Rhizoma Rhei (processed), Fructus Cannabis, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba) such as the enriching blood for moistening the intestine of Guang-amen Hospital, China Traditional Chinese Medicine Instl, there are two problems tradition coloclysis side: the drastic purgation medicine that 1. uses in a large number Radix Et Rhizoma Rhei and so on, clean intestinal lavage although can reach, remove the purpose of vivotoxin, but repeatedly the serious damage of medication intestinal mucosa, the secondary colitis; 2. medicinal liquid mucosa permeability is poor, is difficult to adsorb various toxin in the body by colonic mucosa.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little chronic renal failure enema of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of chronic renal failure enema is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Cortex erythrinaes, 6 ~ 12 parts of Herba Chlorophyti Laxis, go back 3 ~ 10 parts in bobbin, 6 ~ 12 parts of Flos Magnoliae Amoenae, 3 ~ 10 parts of Sanguis Draxonis, 6 ~ 12 parts of Radix Ranunculi Ternatis, 6 ~ 12 parts of Fructus Hordei Germinatus (parched to brown)s, 6 ~ 12 parts of Massa Medicata Fermentata (parched to brown), 6 ~ 12 parts of Mytilus, 1 ~ 5 part of Folium Dalbergiae Mimosoidis, 3 ~ 10 parts of gumshiraz, 10 ~ 25 parts of Ramulus Cinnamomi.
Chinese medicine of the present invention can be prepared from by following method:
(1) volatile oil is extracted in Cortex erythrinae, Radix Ranunculi Ternati, the distilling under reduced pressure of Mytilus coarse powder difference, and mixing for standby use after collecting, the medicinal residues mixing for standby use;
(2) will go back the bobbin decompression and decoct 2 times, each 30min, collecting decoction leaves standstill rear filtration, gets filtrate for later use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Sanguis Draxonis, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and the step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction left standstill rear filtration, gets filtrate for later use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to get dry extract;
(5) gained volatile oil in the step 1 is sprayed in the step 4 gained dry extract, mixing is crossed 100 mesh sieves, gets the concentrated powder of colonic dialysis;
When (6) using, in step 5, add the long-pending warm water of decaploid, mixing in the concentrated powder of gained colonic dialysis.
The pressure of the distilling under reduced pressure in the above-mentioned steps (1) is 0.1Mpa.
The pressure that decompression in the above-mentioned steps (2) decocts is 0.4Mpa.
The pressure of the concentrating under reduced pressure in the above-mentioned steps (4) is 0.4Mpa.
In the prioritization scheme, in step (6), add the long-pending glycerol of monoploid.
Wherein said:
Cortex erythrinae is bark or the root bark of pulse family Erythrinae Arborescentis Erythrina indica Lam..Nature and flavor are bitter, and are flat.Return liver, kidney channel.But the merit wind-damp dispelling, channels sootheing and network vessel quickening.Wind-damp dispelling, the meridian dredging, parasite killing.
Herba Chlorophyti Laxi is herb or the root of feverfew Prenanthes henryi Dunn Prenanthes henryi Dunn.Bitter in the mouth; Cold in nature.But merit heat-clearing and toxic substances removing; The dissipating blood stasis hemostasis.
Also bobbin is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.But merit tonify deficiency subduing the wind syndrome.Main dizzy; Pupil; The wind syndrome of head headache; The weak breath consumption of essence; Early whitening of beard and hair.
Flos Magnoliae Amoenae for Magnoliaceae head Drymotaenium miyoshianum (Mak.) Mak. Magnolia amoena Cheng, is used as medicine with alabastrum.Nature and flavor are bitter, and are cold.But the merit diuresis, detumescence, nourishing the lung to arrest cough.
Sanguis Draxonis, the resin that oozes out for babassu Sanguis Draxonis Daemonorops draco Blume. fruit is through being processed into.Nature and flavor are sweet, salty, and are flat.GUIXIN, Liver Channel.But the merit removing blood stasis and relieving pain, hemostasia and promoting granulation.
Radix Ranunculi Ternati is the dried root of the little Herba Ranunculi Japonici Ranunculus of ranunculaceae plant ternatus Thunb..Nature and flavor are sweet, hot, temperature.Return liver, lung meridian.But the merit eliminating stagnation, detumescence.
Fructus Hordei Germinatus (parched to brown), for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. through the drying of germinateing, fry to burnt brown according to the method for frying, cool sieve dedust bits.Nature and flavor are sweet, and are flat.Return spleen, stomach warp.But the merit promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite moves back newborn relieving distension.
Massa Medicata Fermentata (parched to brown), for the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven that fermentation forms, fry to burnt brown according to frying method.The sweet suffering of nature and flavor, temperature.Enter spleen, stomach warp.But the merit invigorating the spleen and regulating the stomach is in the accent that helps digestion.
Mytilus is Mollusca lamellibranchiata Mytilidae Mytilus crassitesta Lischke Mytilus crassitesta Lischke; Mussel M. edulis L.; Perna uiridis (Linnaeus) M. (Chloromya) smaragdinus Chemnitz; Flat top clam Modiolus modiolus (L.); Philippine pushes up clam M. philippinarum Hanley partially, is used as medicine with meat.Nature and flavor are sweet, temperature.But merit invigorating the liver and kidney; Benefiting essence-blood; Goiter disappears; Remove irritable feverish sensation in the chest, fall the borax poison.
Folium Dalbergiae Mimosoidis is the leaf of leguminous plant trunk rattan Dalbergia mimosoides Franch.GUIXIN; Spleen channel.But merit heat-clearing and toxic substances removing.
Gumshiraz is rosaceous plant peach Prunus persica (L.) Batsch, the resin that flows out on the trunk.Nature and flavor are bitter, flat.Merit can be invigorated blood circulation, and QI invigorating is quenched the thirst.
Ramulus Cinnamomi is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor are hot, sweet, temperature.GUIXIN, lung, urinary bladder channel.But merit diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.
Composition principle: previously the report for the treatment of by Chinese herbs chronic renal failure intestinal canal administration is many, rush down below (Radix et Rhizoma Rhei (processed), Fructus Cannabis, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba) such as enriching blood for moistening the intestine, there are two problems tradition coloclysis side: the drastic purgation medicine that 1. uses in a large number Radix Et Rhizoma Rhei and so on, clean intestinal lavage although can reach, remove the purpose of vivotoxin, but repeatedly the serious damage of medication intestinal mucosa, the secondary colitis; 2. medicinal liquid mucosa permeability is poor, is difficult to adsorb various toxin in the body by colonic mucosa.
Compared with prior art, the present invention has following characteristics:
1, prescription is unique, avoids using bitter cold drastic purgation medicine: get Cortex erythrinae in the side, go back bobbin and be monarch, Cortex erythrinae dosage of record is in " China's book on Chinese herbal medicine ": " taking orally: fry in shallow oil soup, 6-12g "; The inventor experimental results show that (10 ~ 30g) can increase intestinal walls mucosa permeability to middle heavy dose of Cortex erythrinae, promote the intestinal intracavity to exchange, and help mucosa to recover and go back bobbin, and vivotoxin can be effectively removed in the two cooperation, and can not damage intestinal mucosa outward;
2, characteristic of the present invention also is balance and restriction: record Cortex erythrinae in 1. " must joining book on Chinese herbal medicine ": " insufficiency of blood heated person forbidding ", but Renal Failure Patients is often with the resembling of deficiency of YIN-blood, and use Cortex erythrinae this moment then has its hematozemia of fearing and causes the yin asthenia generating intrinsic heat appearance; Therefore add Herba Chlorophyti Laxi and go back bobbin, also but the training of bobbin merit tonify deficiency is basic, and can prevent that Cortex erythrinae from consuming cloudy blood and liver-wind stirring up internally, and the Herba Chlorophyti Laxi bitter in the mouth is cold in nature, utilize its cold heated that prevents on the one hand, but on the other hand its merit dissipating blood stasis hemostasis there is out entire merit in blood system, prevent the Cortex erythrinae moving blood of wandering away, also can not affect Cortex erythrinae simultaneously and work orderly effect; 2. the use of Ramulus Cinnamomi is among the we: a promoting the flow of QI-blood by warming the meridian, and supporing yang activating QI, two Yin Yang balancings are with the bitter cold of balance we invasion by pathogenic cold medicine of a cold nature thing; The application characteristic of Ramulus Cinnamomi is in the prescription of the present invention: measure that larger (" consumption in the Chinese pharmacopoeia is 3 ~ 9g), so too disperse for preventing, gets again Mytilus convergence assistant system, removes irritable feverish sensation in the chest, falls the borax poison;
3, the supplementary drug thing is fewer but better: get the Flos Magnoliae Amoenae assistant in the side and help Herba Chlorophyti Laxi, heat conduction is descending; Radix Ranunculi Ternati and Herba Chlorophyti Laxi collocation have the effect of detoxifcation, eliminating stagnation, pain relieving; Sanguis Draxonis cooperates Cortex erythrinae to increase intestinal walls mucosa permeability; Gumshiraz is invigorated blood circulation, and helps medicine to stay in mucomembranous surface, promotes to absorb;
4, inventor's clinical research is found, the solid protection gastric qi helps the control of the chronic renal failure course of disease and recovers, so select Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown) spleen benefiting and stimulating the appetite;
5, Folium Dalbergiae Mimosoidis is the supplementary drug thing, in " China book on Chinese herbal medicine " record consumption be: " for oral administration: as to fry in shallow oil soup, 9 ~ 15g ", inventor's experimental study are found, get low dose of Folium Dalbergiae Mimosoidis decocting liquid and can improve the intestinal mucosa cytoactive that exsomatizes;
6, the thing homogeneous medicine multiple-effect of getting it filled in the side helps to reduce drug kinds and consumption, does not increase local excitation;
7, medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have preferably curative effect in the following weight parts scope;
8, go back the fruit that bobbin is the orchid Rhizoma Gastrodiae, comparing with Rhizoma Gastrodiae, go back the Esterified Enzyme isozyme (esterase isoenzyme) that bobbin contains, may be the key of its performance pharmacological action, and inventor's experiment draws, and goes back bobbin Esterified Enzyme isozyme content after decompression decocts higher.
9, dosage form is novel, with using with joining, is beneficial to preservation.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: Cortex erythrinae 20g, Herba Chlorophyti Laxi 10g, go back bobbin 6g, Flos Magnoliae Amoenae 10g, Sanguis Draxonis 6g, Radix Ranunculi Ternati 10g, Fructus Hordei Germinatus (parched to brown) 10g, Massa Medicata Fermentata (parched to brown) 10g, Mytilus 10g, Folium Dalbergiae Mimosoidis 2g, gumshiraz 6g, Ramulus Cinnamomi 20g.
The preparation method of embodiment 1 is: with Cortex erythrinae, Herba Chlorophyti Laxi, go back bobbin, Flos Magnoliae Amoenae, Sanguis Draxonis, Radix Ranunculi Ternati, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Mytilus, Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi mixing and water adding and decoct, get filtrate after 30 minutes, medicinal residues add water continuation decoction and get filtrate after 20 minutes, it is the 300ml coloclysis that twice filtrate merging adjusted volume, 5 times weekly.
Embodiment 2, the crude drug weight proportion: 10 parts of Cortex erythrinaes, 6 parts of Herba Chlorophyti Laxis, go back 3 parts in bobbin, 6 parts of Flos Magnoliae Amoenae, 3 parts of Sanguis Draxonis, 6 parts of Radix Ranunculi Ternatis, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 6 parts of Massa Medicata Fermentata (parched to brown), 6 parts of Mytilus, 1 part of Folium Dalbergiae Mimosoidis, 3 parts of gumshiraz, 10 parts of Ramulus Cinnamomi.
Embodiment 2 preparation methoies:
(1) volatile oil is extracted in Cortex erythrinae, Radix Ranunculi Ternati, the distilling under reduced pressure of Mytilus coarse powder difference, and mixing for standby use after collecting, the medicinal residues mixing for standby use;
(2) will go back the bobbin decompression and decoct 2 times, each 30min, collecting decoction leaves standstill rear filtration, gets filtrate for later use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Sanguis Draxonis, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and the step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction left standstill rear filtration, gets filtrate for later use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to get dry extract;
(5) gained volatile oil in the step 1 is sprayed in the step 4 gained dry extract, mixing is crossed 100 mesh sieves, gets the concentrated powder of colonic dialysis;
When (6) using, in step 5, add the long-pending warm water of decaploid, mixing in the concentrated powder of gained colonic dialysis.
Embodiment 3, the crude drug weight proportion: 20 parts of Cortex erythrinaes, 10 parts of Herba Chlorophyti Laxis, go back 6 parts in bobbin, 10 parts of Flos Magnoliae Amoenae, 6 parts of Sanguis Draxonis, 10 parts of Radix Ranunculi Ternatis, 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 parts of Massa Medicata Fermentata (parched to brown), 10 parts of Mytilus, 2 parts of Folium Dalbergiae Mimosoidiss, 6 parts of gumshiraz, 20 parts of Ramulus Cinnamomi.
Embodiment 3 preparation methoies:
(1) volatile oil is extracted in Cortex erythrinae, Radix Ranunculi Ternati, the distilling under reduced pressure of Mytilus coarse powder difference, and mixing for standby use after collecting, the medicinal residues mixing for standby use;
(2) will go back the bobbin decompression and decoct 2 times, each 30min, collecting decoction leaves standstill rear filtration, gets filtrate for later use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Sanguis Draxonis, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and the step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction left standstill rear filtration, gets filtrate for later use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to get dry extract;
(5) gained volatile oil in the step 1 is sprayed in the step 4 gained dry extract, mixing is crossed 100 mesh sieves, gets the concentrated powder of colonic dialysis;
When (6) using, in step 5, add the long-pending warm water of decaploid and the long-pending glycerol of monoploid, mixing in the concentrated powder of gained colonic dialysis.
Wherein, the pressure of the distilling under reduced pressure in the described step (1) is 0.1Mpa; The pressure that decompression in the described step (2) decocts is 0.4Mpa; The pressure of the concentrating under reduced pressure in the described step (4) is 0.4Mpa.
Embodiment 4, the crude drug weight proportion: 30 parts of Cortex erythrinaes, 12 parts of Herba Chlorophyti Laxis, go back 10 parts in bobbin, 12 parts of Flos Magnoliae Amoenae, 10 parts of Sanguis Draxonis, 12 parts of Radix Ranunculi Ternatis, 12 parts of Fructus Hordei Germinatus (parched to brown)s, 12 parts of Massa Medicata Fermentata (parched to brown), 12 parts of Mytilus, 5 parts of Folium Dalbergiae Mimosoidiss, 10 parts of gumshiraz, 25 parts of Ramulus Cinnamomi.
Embodiment 4 preparation methoies:
(1) volatile oil is extracted in Cortex erythrinae, Radix Ranunculi Ternati, the distilling under reduced pressure of Mytilus coarse powder difference, and mixing for standby use after collecting, the medicinal residues mixing for standby use;
(2) will go back the bobbin decompression and decoct 2 times, each 30min, collecting decoction leaves standstill rear filtration, gets filtrate for later use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Sanguis Draxonis, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and the step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction left standstill rear filtration, gets filtrate for later use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to get dry extract;
(5) gained volatile oil in the step 1 is sprayed in the step 4 gained dry extract, mixing is crossed 100 mesh sieves, gets the concentrated powder of colonic dialysis;
When (6) using, in step 5, add the long-pending warm water of decaploid, mixing in the concentrated powder of gained colonic dialysis.
Wherein, the pressure of the distilling under reduced pressure in the described step (1) is 0.1Mpa; The pressure that decompression in the described step (2) decocts is 0.4Mpa; The pressure of the concentrating under reduced pressure in the described step (4) is 0.4Mpa.
Effective combination of said medicine is coordinated mutually, effectively reach the purpose for the treatment of chronic renal failure, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1 data and method.
1.1.1 case is selected: choose in April, 2011 ~ 2013 and be diagnosed as chronic renal failure year January, and meet patient's 90 examples of hemodialysis indication, male 47 examples, women 43 examples; 21～74 years old age, 43.74 ± 11.27 years old mean age; Hemodialysis time average 18 months, protopathy comprise chronic glomerulonephritis 49 examples, chronic pyelonephritis 19 examples, hypertensive nephropathy 10 examples, renal arteriolosclerosis 8 examples, diabetic nephropathy 3 examples, lupus nephritis 1 example.
1.1.2 diagnostic criteria: with reference to " internal medicine " (the 5th edition), the chronic renal failure diagnostic criteria.Dialysis indication: 1. creatinine clearance rate＜10ml/min; 2. BUN〉28.6mmol/L, or SCr 707.2umol/L; 3. hyperpotassemia; 4. metabolic acidosis; 5. mouthful have in uremia's abnormal smells from the patient hold a sinecure the wish forfeiture and feel sick, vomiting etc.; 6. chronic heart failure, renal hypertension or uremic pericarditis use the general treatment nonresponder; 7. uremia's neurological symptom appears, such as personality change, restless legs syndrome etc.
1.1.3 grouping: be divided into matched group, clyster group and colonic dialysis group, every group of 30 examples.Compare in sex, age, the state of an illness, the course of disease before three groups of patient treatments, and the difference not statistically significant (P〉0.05), have comparability.
1.2 method.
1.2.1 Therapeutic Method: all cases are all given high-quality low protein diet and same western medicine, the conventional hemodialysis (CHD) operation.Weekly hemodialysis 3 times of matched group.Weekly hemodialysis 2 times of clyster group, and with gained decoct coloclysis in the embodiment of the invention 1,5 times weekly.The weekly hemodialysis 2 times of colonic dialysis group, and with gained colonic dialysis liquid colonic dialysis in the embodiment of the invention 3,5 times weekly.Treating the course for the treatment of is 4 months.
1.2.2 observation index: blood urea nitrogen (BUN), serum creatinine (Scr), total serum protein (TP), hemoglobin (Hb), residual renal function (RRF), the carbamide of measuring the treatment front and back are removed index (Kt/V).
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ
2Check.
2 results.
2.1 three groups of residual renal functions (RRF) relatively: matched group, clyster group and colonic dialysis group RRF are respectively 6.61 ± 1.27,6.62 ± 1.16,6.72 ± 1.16 before the treatment.Treat after 4 months, obvious decline all appears in three groups of RRF, is respectively 2.71 ± 1.16,3.18 ± 1.46,3.22 ± 1.61.Three groups are relatively, no significant difference (P〉0.05).
2.2 three groups of carbamide are removed index (Kt/V) relatively: three groups of Kt/V are respectively 1.71 ± 0.16,1.26 ± 0.14,1.22 ± 0.15.Three groups are relatively, no significant difference (P〉0.05).
2.3 adverse reaction rate: obvious adverse reaction does not all appear in three groups of patients.
3. conclusion.
This result of study shows, clyster group of the present invention and colonic dialysis group treatment chronic renal failure can be in the situation that the equal curative effect of maintenance reduce the hemodialysis number of times effectively.Have that untoward reaction is light, the higher advantage of safety.
Claims (5)
1. treat the preparation method that enema is used in chronic renal failure for one kind, it is characterized in that, crude drug comprises: Cortex erythrinae, Herba Chlorophyti Laxi, go back bobbin, Flos Magnoliae Amoenae, Sanguis Draxonis, Radix Ranunculi Ternati, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Mytilus, Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi, its preparation method is comprised of following steps:
(1) volatile oil is extracted in Cortex erythrinae, Radix Ranunculi Ternati, the distilling under reduced pressure of Mytilus coarse powder difference, and mixing for standby use after collecting, the medicinal residues mixing for standby use;
(2) will go back the bobbin decompression and decoct 2 times, each 30min, collecting decoction leaves standstill rear filtration, gets filtrate for later use;
(3) gained medicinal residues in Herba Chlorophyti Laxi, Flos Magnoliae Amoenae, Sanguis Draxonis, Fructus Hordei Germinatus (parched to brown), Massa Medicata Fermentata (parched to brown), Folium Dalbergiae Mimosoidis, gumshiraz, Ramulus Cinnamomi and the step 1 are added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction left standstill rear filtration, gets filtrate for later use;
(4) step 2 gained filtrate and step 3 gained filtrate are merged, concentrating under reduced pressure becomes dry extract, pulverizes to get dry extract;
(5) gained volatile oil in the step 1 is sprayed in the step 4 gained dry extract, mixing is crossed 100 mesh sieves, gets the concentrated powder of colonic dialysis;
When (6) using, in step 5, add the long-pending warm water of decaploid, mixing in the concentrated powder of gained colonic dialysis.
2. according to claim 1ly a kind ofly treat chronic renal failure with the preparation method of enema, it is characterized in that: the pressure of the distilling under reduced pressure in the described step (1) is 0.1Mpa.
3. according to claim 1ly a kind ofly treat chronic renal failure with the preparation method of enema, it is characterized in that: the pressure that the decompression in the described step (2) decocts is 0.4Mpa.
4. according to claim 1ly a kind ofly treat chronic renal failure with the preparation method of enema, it is characterized in that: the pressure of the concentrating under reduced pressure in the described step (4) is 0.4Mpa.
5. a kind of preparation method that enema is used in chronic renal failure for the treatment of according to claim 1 is characterized in that: add the long-pending glycerol of monoploid in step (6).
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| CN104257841A (en) * | 2014-10-04 | 2015-01-07 | 李红光 | Traditional Chinese medicine preparation for treating renal failure and preparation method thereof |
| CN104815194A (en) * | 2013-10-15 | 2015-08-05 | 李世胜 | Method for preparing medicine for treating diabetic nephropathy |
| CN105726998A (en) * | 2014-03-24 | 2016-07-06 | 孙峰 | Preparation method of medicine for treating posthepatitic syndrome |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857429A (en) * | 2005-04-30 | 2006-11-08 | 何元仲 | Chinese medicine enema for treating acute pancreatitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1857429A (en) * | 2005-04-30 | 2006-11-08 | 何元仲 | Chinese medicine enema for treating acute pancreatitis |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316258A (en) * | 2013-07-01 | 2013-09-25 | *** | Medicine composition for treating infantile vaginitis |
| CN103316269A (en) * | 2013-07-01 | 2013-09-25 | 付海霞 | Medicine composition for treating primary enuresis |
| CN104815194A (en) * | 2013-10-15 | 2015-08-05 | 李世胜 | Method for preparing medicine for treating diabetic nephropathy |
| CN105726998A (en) * | 2014-03-24 | 2016-07-06 | 孙峰 | Preparation method of medicine for treating posthepatitic syndrome |
| CN104257841A (en) * | 2014-10-04 | 2015-01-07 | 李红光 | Traditional Chinese medicine preparation for treating renal failure and preparation method thereof |
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| CN103301356B (en) | 2015-02-25 |
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