CN105661021A - Immunity-improving feed additive and preparation method thereof - Google Patents
Immunity-improving feed additive and preparation method thereof Download PDFInfo
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- CN105661021A CN105661021A CN201511011200.8A CN201511011200A CN105661021A CN 105661021 A CN105661021 A CN 105661021A CN 201511011200 A CN201511011200 A CN 201511011200A CN 105661021 A CN105661021 A CN 105661021A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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Abstract
The invention discloses a immunity-improving feed additive. The immunity-improving feed additive comprises the following ingredients in parts by weight: 0.5-2 parts of ferrous glycine, 0.5-2 parts of zinc glycine, 4-8 parts of beta-mannase, 5-10 parts of yeast powder, 8-15 parts of lees and 2-8 parts of traditional Chinese medicine compound; ant the traditional Chinese medicine compound is prepared from the following raw material: Chinese mugwort leaves, Moringa leaves and chrysanthemum flowers, wherein the mass ratio of the Chinese mugwort leaves to the Moringa leaves to the chrysanthemum flowers is (2-4): (1-2): (6-10). The immunity-improving feed additive belongs to the technical field of feed additives. The feed additive provided by the invention has the function of improving fed animals. Moreover, the feed additive also has the advantage of good palatability.
Description
Technical field
The invention belongs to field of feed additive technology, particularly relate to a kind of feed additive improving immunologic function and preparation method thereof.
Background technology
Feed additive refers to a small amount of or trace substance added in Feed Manufacturing processing, use procedure, and in feedstuff, consumption seldom but acts on significantly. Feed additive is the raw material that modern feed industry necessarily uses, and to strengthening normal feedstuff nutritive value, improves breeding performonce fo animals, it is ensured that animal health, saves feed cost, and improving the aspects such as livestock products quality has obvious effect. Feed additive is commonly divided into nutritional feed additive and the big class of non-nutritional feed additive two, nutritional feed additive is mainly used in supplementing aminoacid, vitamin, trace element etc., and non-nutritive additive is mainly used in supplementing such as enzyme preparation, active bacteria formulation, acidulant etc., keep healthy or disease-resistant effect to play.
Chinese patent CN103262945 discloses a kind of feed additive improving people's pig immunity, this feed additive is made up of Polyporus, the Radix Rehmanniae, Radix Ophiopogonis, Radix Notoginseng, Fructus Ligustri Lucidi etc., by rationally selecting Chinese herbal medicine genuine medicinal materials, prescription has effect of tonifying speen and tonifying kidney, depressed liver-energy dispersing and QI regulating, the body resistance strengthening and constitution consolidating, the pyrolysis reading that disappears, people's Sanguis sus domestica can be improved disappear the contents level of immunoglobulin IgG, IgA, IgM etc., improve people's pig immunity.
Chinese patent CN103734541 discloses the biology feed additive of a kind of effective enhancing pigling immunity, this additive is made up of by certain proportioning composite Chinese herbal and microbial ecological agent, composite Chinese herbal is made up of Radix Notoginseng, Herba Dendrobii, Cacumen Platycladi, the Cortex Eucommiae, Radix Rhodiolae etc., and microbial ecological agent is made up of bacillus subtilis, Bacillus licheniformis, bacillus bifidus etc. This feed additive adopts Chinese herbal medicine and microbial ecological agent to carry out organic assembling, by working in coordination with mutually, has invigorating the stomach and promoting digestion, promoting blood circulation to remove blood stasis, improves the effect of intestinal health and enhancing immunity.
Chinese herbal medicine obtains wide application in field of fodder, but existing feed additive needs the Chinese medicine using relatively multi-flavor number to prepare, the shortcoming that composition is more complicated.
Summary of the invention
For solving problems of the prior art, inventor is screened by the lot of experiments component to feed additive and content, unforeseeable discovery: by the addition of the Chinese medicine composition that Folium Artemisiae Argyi, leaf of Moringa and Flos Chrysanthemi prepare, combine, with ferrum glycinate etc., the feed additive obtained and there is the effect of the immunologic function improving letting animals feed and the advantage with good palatability.
The purpose of the present invention will be further described in detail below reflect and description.
The present invention provides a kind of feed additive improving immunologic function, including the component of following parts by weight: ferrum glycinate 0.5 ~ 2 part, zinc glycinate 0.5 ~ 2 part, 'beta '-mannase 4 ~ 8 parts, 10 ~ 15 parts of distiller grains and Chinese medicine composition 4 ~ 10 parts; The raw material of preparing of described Chinese medicine composition includes: Folium Artemisiae Argyi, leaf of Moringa and Flos Chrysanthemi, and the weight ratio of Folium Artemisiae Argyi, leaf of Moringa and Flos Chrysanthemi is 2 ~ 4:1 ~ 2:6 ~ 10.
Preferably, the feed additive of described raising immunologic function, including the component of following parts by weight: ferrum glycinate 1 ~ 2 part, zinc glycinate 1 ~ 2 part, 'beta '-mannase 6 ~ 8 parts, 12 ~ 15 parts of distiller grains and Chinese medicine composition 6 ~ 10 parts.
Preferably, the feed additive of described raising immunologic function, including the component of following parts by weight: ferrum glycinate 1 part, zinc glycinate 2 parts, 'beta '-mannase 6 parts, 14 parts of distiller grains and Chinese medicine composition 8 parts.
Preferably, the feed additive of described raising immunologic function, also include glucose 1 ~ 3 part. The present invention according to actual needs, then can also add the nutritional labeling such as vitamin, immunoglobulin.
Preferably, the preparation of described Chinese medicine composition comprises the steps:
S1 weighs Folium Artemisiae Argyi, leaf of Moringa respectively, pulverizing obtains coarse powder, add the alcoholic solution of concentration of volume percent 50 ~ 80%, the solid-liquid ratio of described coarse powder and alcoholic solution is 1g:(4 ~ 10) mL, extracts 1 ~ 3h, filters under counterflow condition, retain filtering residue, by filtrate reduced in volume and ethanol is evaporated off, dry, obtain extract;
S2 weighs Flos Chrysanthemi, adds described filtering residue, pulverizes through super micron mill and obtains superfine powder, mixes with described extract, obtain Chinese medicine composition.
Preferably, the concentration of volume percent of described alcoholic solution is 60%, and the solid-liquid ratio of described coarse powder and alcoholic solution is 1g:6mL.
Correspondingly, the preparation method that present invention also offers the feed additive improving immunologic function, comprise the steps: to weigh ferrum glycinate, zinc glycinate, 'beta '-mannase, distiller grains and Chinese medicine composition respectively, mixing, granulate, dry, obtain improving the feed additive of immunologic function.
Preferably, the preparation of described Chinese medicine composition comprises the steps:
S1 weighs Folium Artemisiae Argyi, leaf of Moringa respectively, pulverizing obtains coarse powder, add the alcoholic solution of concentration of volume percent 50 ~ 80%, the solid-liquid ratio of described coarse powder and alcoholic solution is 1g:(4 ~ 10) mL, extracts 16 ~ 24h, filters under counterflow condition, retain filtering residue, by filtrate reduced in volume and ethanol is evaporated off, dry, obtain extract;
S2 weighs Flos Chrysanthemi, adds described filtering residue, pulverizes through super micron mill and obtains superfine powder, mixes with described extract, obtain Chinese medicine composition.
Preferably, the concentration of volume percent of described alcoholic solution is 60%, and the solid-liquid ratio of described coarse powder and alcoholic solution is 1g:6mL; The admission pressure of described super micron mill is 0.4 ~ 0.6Mpa, and pulverizing pressure is 0.6 ~ 0.9Mpa.
Additionally, present invention also offers the feed additive improving immunologic function purposes in preparing pig feed.
Compared with prior art, the invention has the beneficial effects as follows: feed additive provided by the invention is without chemicalses such as antibiotic, the synergism such as the Chinese medicine composition prepared by Folium Artemisiae Argyi, leaf of Moringa and Flos Chrysanthemi and ferrum glycinate, need not add microbial ecological agent etc., and component is simple, consumption is few, cost is low, has the effect of the immunologic function improving letting animals feed, the multiple pathogenic bacteria causing diarrhoea can be produced inhibitory action, and there is the advantage of good palatability, be conducive to the healthy growth of letting animals feed. Additionally, the preparation method of feed additive provided by the invention is simple, manufacturing cycle is short, it is adaptable to Industry Promotion.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further detail.
Embodiment one Chinese medicine composition
The raw material of preparing of Chinese medicine composition includes Folium Artemisiae Argyi 10 parts, leaf of Moringa 5 parts, Flos Chrysanthemi 20 parts.
Preparation method: weigh Folium Artemisiae Argyi, leaf of Moringa respectively, pulverizing obtains coarse powder, add the alcoholic solution of concentration of volume percent 60%, the solid-liquid ratio of described coarse powder and alcoholic solution is 1g:6mL, extracts 1.5h, filter under counterflow condition, retain filtering residue, by filtrate reduced in volume and ethanol is evaporated off, dry, obtain extract; Weighing Flos Chrysanthemi, add described filtering residue, pulverize through super micron mill and obtain superfine powder, the admission pressure of super micron mill is 0.5Mpa, and pulverizing pressure is 0.8Mpa, and superfine powder mixes with described extract, obtains Chinese medicine composition.
Embodiment two Chinese medicine composition
The raw material of preparing of Chinese medicine composition includes Folium Artemisiae Argyi 12 parts, leaf of Moringa 4 parts, Flos Chrysanthemi 24 parts.
Preparation method: weigh Folium Artemisiae Argyi, leaf of Moringa respectively, pulverizing obtains coarse powder, add the alcoholic solution of concentration of volume percent 75%, the solid-liquid ratio of described coarse powder and alcoholic solution is 1g:5mL, extracts 2h, filter under counterflow condition, retain filtering residue, by filtrate reduced in volume and ethanol is evaporated off, dry, obtain extract; Weighing Flos Chrysanthemi, add described filtering residue, pulverize through super micron mill and obtain superfine powder, the admission pressure of super micron mill is 0.5Mpa, and pulverizing pressure is 0.8Mpa, and superfine powder mixes with described extract, obtains Chinese medicine composition.
Comparative example one
The raw material of preparing of Chinese medicine composition includes leaf of Moringa 15 parts, Flos Chrysanthemi 20 parts.
Preparation method: weigh leaf of Moringa, pulverizes and obtains coarse powder, and the solid-liquid ratio adding the alcoholic solution of concentration of volume percent 60%, described coarse powder and alcoholic solution is 1g:6mL, extract 1.5h under counterflow condition, filter, retain filtering residue, by filtrate reduced in volume and ethanol is evaporated off, dry, obtain extract; Weighing Flos Chrysanthemi, add described filtering residue, pulverize through super micron mill and obtain superfine powder, the admission pressure of super micron mill is 0.5Mpa, and pulverizing pressure is 0.8Mpa, and superfine powder mixes with described extract, obtains Chinese medicine composition.
Comparative example two
The raw material of preparing of Chinese medicine composition includes Folium Artemisiae Argyi 15 parts, Flos Chrysanthemi 20 parts.
Preparation method: weigh Folium Artemisiae Argyi, pulverizes and obtains coarse powder, and the solid-liquid ratio adding the alcoholic solution of concentration of volume percent 60%, described coarse powder and alcoholic solution is 1g:6mL, extract 1.5h under counterflow condition, filter, retain filtering residue, by filtrate reduced in volume and ethanol is evaporated off, dry, obtain extract; Weighing Flos Chrysanthemi, add described filtering residue, pulverize through super micron mill and obtain superfine powder, the admission pressure of super micron mill is 0.5Mpa, and pulverizing pressure is 0.8Mpa, and superfine powder mixes with described extract, obtains Chinese medicine composition.
Embodiment three feed additive
Feed additive includes the component of following parts by weight: the Chinese medicine composition 8 parts that ferrum glycinate 1 part, zinc glycinate 2 parts, 'beta '-mannase 6 parts, 14 parts of distiller grains and embodiment one prepare.
Preparation method: weigh ferrum glycinate, zinc glycinate, 'beta '-mannase, distiller grains and Chinese medicine composition respectively, mixing, granulate, obtain feed additive.
Embodiment four feed additive
Feed additive includes the component of following parts by weight: the Chinese medicine composition 6 parts that ferrum glycinate 2 parts, zinc glycinate 1 part, 'beta '-mannase 8 parts, 12 parts of distiller grains and embodiment two prepare.
Preparation method is with embodiment three.
Embodiment five feed additive
Feed additive includes the component of following parts by weight: the Chinese medicine composition 8 parts that ferrum glycinate 1 part, zinc glycinate 2 parts, 'beta '-mannase 6 parts, 14 parts of distiller grains, glucose 1 part and embodiment one prepare.
Preparation method is with embodiment three.
Comparative example three
Feed additive includes the component of following parts by weight: the Chinese medicine composition 8 parts that ferrum glycinate 1 part, zinc glycinate 2 parts, 'beta '-mannase 6 parts, 14 parts of distiller grains and comparative example one prepare.
Preparation method is with embodiment three.
Comparative example four
Feed additive includes the component of following parts by weight: the Chinese medicine composition 8 parts that ferrum glycinate 1 part, zinc glycinate 2 parts, 'beta '-mannase 6 parts, 14 parts of distiller grains and comparative example two prepare.
Preparation method is with embodiment three.
Comparative example five
Feed additive includes the component of following parts by weight: the Chinese medicine composition 8 parts that ferrum glycinate 1 part, zinc glycinate 2 parts, glucoseoxidase 6 parts, 14 parts of distiller grains and embodiment one prepare.
Preparation method is with embodiment three.
The toxicity test of feed additive
Adopting horn method to carry out the acute toxicity test of feed additive, take 20 healthy mices (Kunming kind), be randomly divided into 2 groups, often group 10, the feed additive that test group mice gavage 1g every day embodiment three prepares, control group mice is gavage normal saline then. Observing the reaction of mice, find no abnormal response, after 7 days, dislocation is put to death, and carries out hepatic and renal tissue and observe after dissection, and also no abnormal, serum GPT isoreactivity compares without significant difference with matched group. Therefore, feed additive provided by the invention has safety.
The effect test example of feed additive
Choose age in days be 28 ~ 35, the healthy DLY piglet 120 of body weight 6.5-7.0kg, it is randomly divided into 6 groups, often group 20, body weight no difference of science of statistics between each group piglet, through ear vein blood sampling detection blood parameters, respectively organize the content no difference of science of statistics of the total protein between piglet, globulin, IgG, IgA, IgM. On the basis of basal diet, embodiment three groups adds the feed additive that embodiment three prepares, based on addition the 0.1% of daily ration; Embodiment five groups adds the feed additive that embodiment five prepares, based on addition the 0.1% of daily ration; Comparative example three groups adds the feed additive that comparative example three prepares, based on addition the 0.1% of daily ration; Comparative example four groups adds the feed additive that comparative example four prepares, based on addition the 0.1% of daily ration; Comparative example five groups adds the feed additive that comparative example five prepares, based on addition the 0.1% of daily ration; Matched group is without the feed additive beyond basal diet. Terminating test after feeding 30 days, weigh, synotus venous blood collection detection blood parameters, result is as shown in table 1, adopts SPSS17.0 to carry out the statistical analysis of experimental data.
Note: compared with matched group, * P < 0.05, * * P < 0.01; Compared with comparative example three groups,&P < 0.05,&&P < 0.01; Compared with comparative example four groups,#P < 0.05,##P < 0.01; Compared with comparative example five groups,◇P < 0.05,◇◇P < 0.01.
As known from Table 1, compared with matched group, embodiment three groups and embodiment five groups are remarkably improved the content (having significant difference) of the end weight of DLY piglet, total protein, globulin, IgG and IgA, can improve the content (not having significant difference) of IgM. Additionally, embodiment three groups and embodiment five groups are better than comparative example three groups to comparative example five groups in improving the content of body weight, total protein, globulin etc. Therefore, feed additive provided by the invention can improve the immunologic function of DLY piglet.
Above content is in conjunction with concrete preferred implementation further description made for the present invention, it is impossible to assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, it is also possible to make some simple deduction or replace, protection scope of the present invention all should be considered as belonging to.
Claims (10)
1. the feed additive improving immunologic function, it is characterised in that: include the component of following parts by weight: ferrum glycinate 0.5 ~ 2 part, zinc glycinate 0.5 ~ 2 part, 'beta '-mannase 4 ~ 8 parts, 10 ~ 15 parts of distiller grains and Chinese medicine composition 4 ~ 10 parts; The raw material of preparing of described Chinese medicine composition includes: Folium Artemisiae Argyi, leaf of Moringa and Flos Chrysanthemi, and the weight ratio of Folium Artemisiae Argyi, leaf of Moringa and Flos Chrysanthemi is 2 ~ 4:1 ~ 2:6 ~ 10.
2. the feed additive of raising immunologic function according to claim 1, it is characterised in that: include the component of following parts by weight: ferrum glycinate 1 ~ 2 part, zinc glycinate 1 ~ 2 part, 'beta '-mannase 6 ~ 8 parts, 12 ~ 15 parts of distiller grains and Chinese medicine composition 6 ~ 10 parts.
3. the feed additive of raising immunologic function according to claim 1 and 2, it is characterised in that: include the component of following parts by weight: ferrum glycinate 1 part, zinc glycinate 2 parts, 'beta '-mannase 6 parts, 14 parts of distiller grains and Chinese medicine composition 8 parts.
4. the feed additive of raising immunologic function according to claim 1 and 2, it is characterised in that: also include glucose 1 ~ 3 part.
5. the feed additive of raising immunologic function according to claim 1 and 2, it is characterised in that: the preparation of described Chinese medicine composition comprises the steps:
S1 weighs Folium Artemisiae Argyi, leaf of Moringa respectively, pulverizing obtains coarse powder, add the alcoholic solution of concentration of volume percent 50 ~ 80%, the solid-liquid ratio of described coarse powder and alcoholic solution is 1g:(4 ~ 10) mL, extracts 1 ~ 3h, filters under counterflow condition, retain filtering residue, by filtrate reduced in volume and ethanol is evaporated off, dry, obtain extract;
S2 weighs Flos Chrysanthemi, adds described filtering residue, pulverizes through super micron mill and obtains superfine powder, mixes with described extract, obtain Chinese medicine composition.
6. the feed additive of raising immunologic function according to claim 5, it is characterised in that: the concentration of volume percent of described alcoholic solution is 60%, and the solid-liquid ratio of described coarse powder and alcoholic solution is 1g:6mL.
7. the preparation method of the feed additive of raising immunologic function according to claim 1, it is characterized in that: comprise the steps: to weigh ferrum glycinate, zinc glycinate, 'beta '-mannase, distiller grains and Chinese medicine composition respectively, mixing, granulate, dry, obtain improving the feed additive of immunologic function.
8. the preparation method of the feed additive of raising immunologic function according to claim 7, it is characterised in that: the preparation of described Chinese medicine composition comprises the steps:
S1 weighs Folium Artemisiae Argyi, leaf of Moringa respectively, pulverizing obtains coarse powder, add the alcoholic solution of concentration of volume percent 50 ~ 80%, the solid-liquid ratio of described coarse powder and alcoholic solution is 1g:(4 ~ 10) mL, extracts 16 ~ 24h, filters under counterflow condition, retain filtering residue, by filtrate reduced in volume and ethanol is evaporated off, dry, obtain extract;
S2 weighs Flos Chrysanthemi, adds described filtering residue, pulverizes through super micron mill and obtains superfine powder, mixes with described extract, obtain Chinese medicine composition.
9. the preparation method of the feed additive of raising immunologic function according to claim 8, it is characterised in that: the concentration of volume percent of described alcoholic solution is 60%, and the solid-liquid ratio of described coarse powder and alcoholic solution is 1g:6mL;The admission pressure of described super micron mill is 0.4 ~ 0.6Mpa, and pulverizing pressure is 0.6 ~ 0.9Mpa.
10. the feed additive of the raising immunologic function according to any one of claim 1 to 9 purposes in preparing pig feed.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201511011200.8A CN105661021A (en) | 2015-12-30 | 2015-12-30 | Immunity-improving feed additive and preparation method thereof |
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| CN201511011200.8A CN105661021A (en) | 2015-12-30 | 2015-12-30 | Immunity-improving feed additive and preparation method thereof |
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| CN105661021A true CN105661021A (en) | 2016-06-15 |
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| CN201511011200.8A Withdrawn CN105661021A (en) | 2015-12-30 | 2015-12-30 | Immunity-improving feed additive and preparation method thereof |
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| CN108077622A (en) * | 2017-12-29 | 2018-05-29 | 佛山市南海东方澳龙制药有限公司 | A kind of additive and preparation method thereof for improving sow production performance and include its mixed fodder |
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| CN108077622A (en) * | 2017-12-29 | 2018-05-29 | 佛山市南海东方澳龙制药有限公司 | A kind of additive and preparation method thereof for improving sow production performance and include its mixed fodder |
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Application publication date: 20160615 |