CN105628779A - Online monitor of propofol in blood, and application thereof - Google Patents
Online monitor of propofol in blood, and application thereof Download PDFInfo
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- CN105628779A CN105628779A CN201410587876.0A CN201410587876A CN105628779A CN 105628779 A CN105628779 A CN 105628779A CN 201410587876 A CN201410587876 A CN 201410587876A CN 105628779 A CN105628779 A CN 105628779A
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Abstract
An online monitor of propofol in blood is designed in the invention. Continuous online monitoring of the concentration of propofol in human body blood during operation is realized on the basis of an ion mobility spectrometry technology and a headspace sampling technology.
Description
Technical field
The present invention, based on ion mobility spectrometry and headspace sampling technology, devises the on-line computing model of propofol in a kind of blood, with the monitoring of the anesthesia of patient degree of depth in Rhizoma Atractylodis Macrocephalae.
Background technology
Propofol is a kind of conventional intravenous anesthesia agent, has been widely used in the calmness that induction of anesthesia, anesthesia maintenance and ICU are heavy patient. In operation process, often there is close dependency with its depth of anesthesia in the concentration of propofol in patient blood, therefore monitors the concentration of propofol in patient blood in art and has great importance for Anesthesia Monitoring.
Being presently used for measuring in blood the method for propofol mainly includes high performance liquid chromatography and gas chromatography mass spectrometry etc. But, blood, as a complicated biological sample, must carrying out sample pretreatment before it carries out chromatographic isolation, thus causing above method consuming time longer, and mostly being off-line analysis, it is impossible to fully meet the demand of Anesthesia Monitoring clinically.
Ion mobility spectrometry (IonMobilitySpectrometry, IMS) a kind of separation detection technique that technology 20 century 70 occurs, compared with the conventional art such as mass spectrum, chromatograph, it has the features such as simple in construction, highly sensitive, analysis speed is fast, has been widely used in the on-line monitoring etc. of explosive examination, drugs inspection and VOCs. Ionic migration spectrometer is mainly made up of ion source, ion gate, migration area and detector. Ion source makes sample molecule, N2��O2Ionizing with steam, the ion of generation is easy to and molecule generation ion molecule reaction, obtains multi-products ion. Ion enters migration area by the ion gate periodically opened under the ordering about of electric field, float edema caused by disorder of QI with the neutrality of adverse current to be continually colliding, owing to these ions have different migration rates in the electric field so that different ions is separated, successively arrive detector. The present invention, based on Ion mobility spectrometry, the method adopting headspace sampling, devises the on-line computing model of propofol in a kind of blood.
Summary of the invention
The present invention devises the on-line computing model of propofol in a kind of blood, including headspace sampling room and be core with transference tube ionic migration spectrometer.
Headspace sampling room is an airtight hollow box body, casing be respectively arranged on the left side and the right side carrier gas inlet and carrier gas gas outlet, carrier gas inlet is connected with carrier gas source of the gas, and carrier gas outlet is connected with the air inlet of transference tube; The top of casing is provided with a through hole; One blood catheter outlet is connected with box house by this through hole or stretches to the middle and upper part of casing, and blood catheter entrance is connected with blood source to be measured.
Transference tube includes the ionization source, ion gate, migration area, aperture plate and the ion receiving pole that sequentially coaxially arrange in housing; Housing sidewall near ion receiving pole is provided with drift gas entrance, and drift gas entrance is connected with drift gas source of the gas; Housing sidewall near ionization source is provided with and the air inlet being connected in housing, and air inlet is connected with the carrier gas gas outlet of headspace sampling room; Housing sidewall between ion gate and ionization source is provided with gas outlet, this gas outlet's emptying.
Blood source to be measured is the container with heater, and it can by the blood heat placed in it to 30-60 DEG C.
Heater is heater strip or heating cloth.
Being placed with a container in the bottom of the casing of headspace sampling room, container is placed in immediately below blood catheter outlet, and container can be removed and placed at any time by casing.
Having a through hole in the bottom of the casing of headspace sampling room, through hole is provided with an active clapboard; Active clapboard and the bottom tight engagement of casing, controlled the folding of through hole, the connection namely controlling box house and air or isolation by active clapboard.
The ionization source of transference tube includes radioactive ionization gauge source, light ionization source or discharge ionization source.
Headspace sampling is indoor, and blood sample continuously flow to blood catheter and exports and formed drop of blood, and carrier gas is brought the headspace gas of drop of blood into transference tube and detected.
When drop of blood hangs on the outlet of blood catheter, the dividing plate of box bottom is closed; When drop of blood comes off, the dividing plate of box bottom is in open mode.
The present invention devises the on-line computing model of propofol in a kind of blood. Based on Ion mobility spectrometry and headspace sampling technology, it is achieved that the continuous on-line monitoring of concentration of propofol in blood of human body in art.
Accompanying drawing explanation
Fig. 1 is the structural representation of the on-line computing model of propofol in blood in the present invention.
Wherein, 1 is carrier gas inlet, and 2 is blood catheter entrance, 3 export for blood catheter, and 4 is drop of blood, and 5 is dividing plate, 6 export for carrier gas, and 7 is the air inlet of transference tube, and 8 is ionization source, 9 is gas outlet, and 10 is ion gate, and 11 is migration area, 12 is dead ring, and 13 is conducting ring, and 14 is aperture plate, 15 is ion receiving pole, and 16 is drift gas entrance.
The structural representation of headspace sampling room when Fig. 2 is that in the present invention, drop of blood comes off.
Detailed description of the invention
The present invention devises the on-line computing model of propofol in a kind of blood, including headspace sampling room and be core with transference tube ionic migration spectrometer.
Headspace sampling room is an airtight hollow box body, casing be respectively arranged on the left side and the right side carrier gas inlet and carrier gas gas outlet, carrier gas inlet is connected with carrier gas source of the gas, and carrier gas outlet is connected with the air inlet of transference tube; The top of casing is provided with a through hole; One blood catheter outlet is connected with box house by this through hole or stretches to the middle and upper part of casing, and blood catheter entrance is connected with blood source to be measured;
Ionization source that transference tube includes sequentially coaxially arranging in housing, ion gate, migration area, aperture plate) and ion receiving pole; Housing sidewall near ion receiving pole is provided with drift gas entrance, and drift gas entrance is connected with drift gas source of the gas; Housing sidewall near ionization source is provided with and the air inlet being connected in housing, and air inlet is connected with the carrier gas gas outlet of headspace sampling room; Housing sidewall between ion gate and ionization source is provided with gas outlet, this gas outlet's emptying.
Blood source to be measured is the container with heater, and it can by the blood heat placed in it to 30-60 DEG C.
Heater is heater strip or heating cloth.
Being placed with a container in the bottom of the casing of headspace sampling room, container is placed in immediately below blood catheter outlet, and container can be removed and placed at any time by casing.
Having a through hole in the bottom of the casing of headspace sampling room, through hole is provided with an active clapboard; Active clapboard and the bottom tight engagement of casing, controlled the folding of through hole, the connection namely controlling box house and air or isolation by active clapboard.
The ionization source of transference tube includes radioactive ionization gauge source, light ionization source or discharge ionization source.
Headspace sampling is indoor, and blood sample continuously flow to blood catheter and exports and formed drop of blood, and carrier gas is brought the headspace gas of drop of blood into transference tube and detected.
When drop of blood hangs on the outlet of blood catheter, the dividing plate of box bottom is closed; When drop of blood comes off, the dividing plate of box bottom is in open mode.
Headspace sampling is indoor, and blood sample continuously flow to blood catheter and exports and form drop of blood. When drop of blood hangs on the outlet of blood catheter, the dividing plate of box bottom is closed, and carrier gas is brought the headspace gas of drop of blood into transference tube and detected. When drop of blood drops to the container below the forward of blood catheter exit, the dividing plate of box bottom is in open mode, and this container is removed; Only when the exit of blood catheter forms new drop of blood, placing new container below the forward of blood catheter exit, dividing plate is closed again, starts next one detection circulation.
Claims (8)
1. an on-line computing model for propofol in blood, including headspace sampling room and be core with transference tube ionic migration spectrometer, it is characterised in that:
Headspace sampling room is an airtight hollow box body, casing be respectively arranged on the left side and the right side carrier gas inlet (1) and carrier gas gas outlet (6), carrier gas inlet is connected with carrier gas source of the gas, and carrier gas outlet is connected with the air inlet (7) of transference tube; The top of casing is provided with a through hole; One blood catheter outlet (3) is connected with box house by this through hole or stretches to the middle and upper part of casing, and blood catheter entrance (2) is connected with blood source to be measured;
Transference tube includes the ionization source (8), ion gate (10), migration area (11), aperture plate (14) and the ion receiving pole (15) that sequentially coaxially arrange in housing; Housing sidewall near ion receiving pole is provided with drift gas entrance (16), and drift gas entrance is connected with drift gas source of the gas; Housing sidewall near ionization source is provided with and the air inlet (7) being connected in housing, and air inlet is connected with the carrier gas gas outlet of headspace sampling room; Housing sidewall between ion gate and ionization source is provided with gas outlet (9), this gas outlet's emptying.
2. the on-line computing model of propofol in blood according to claim 1, it is characterised in that:
Blood source to be measured is the container with heater, and it can by the blood heat placed in it to 30-60 DEG C.
3. the on-line computing model of propofol in blood according to claim 2, it is characterised in that:
Described heater is heater strip or heating cloth.
4. the on-line computing model of propofol in blood according to claim 1, it is characterised in that:
Being placed with a container in the bottom of the casing of headspace sampling room, container is placed in immediately below blood catheter outlet, and container can be removed and placed at any time by casing.
5. the on-line computing model of propofol in blood according to claim 1, it is characterised in that:
Having a through hole in the bottom of the casing of headspace sampling room, through hole is provided with an active clapboard (5); Active clapboard and the bottom tight engagement of casing, controlled the folding of through hole, the connection namely controlling box house and air or isolation by active clapboard.
6. the on-line computing model of propofol in blood according to claim 1, it is characterised in that: the ionization source of transference tube includes radioactive ionization gauge source, light ionization source or discharge ionization source.
7. the application of the on-line computing model of propofol in the arbitrary described blood of claim 1-6, it is characterized in that: headspace sampling is indoor, blood sample continuously flow to blood catheter and exports and formed drop of blood (4), and carrier gas is brought the headspace gas of drop of blood into transference tube and detected.
8. the application of the on-line computing model of propofol in blood according to claim 7, it is characterised in that: when drop of blood hangs on the outlet of blood catheter, the dividing plate of box bottom is closed; When drop of blood comes off, the dividing plate of box bottom is in open mode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410587876.0A CN105628779A (en) | 2014-10-28 | 2014-10-28 | Online monitor of propofol in blood, and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410587876.0A CN105628779A (en) | 2014-10-28 | 2014-10-28 | Online monitor of propofol in blood, and application thereof |
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| CN105628779A true CN105628779A (en) | 2016-06-01 |
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| CN201410587876.0A Pending CN105628779A (en) | 2014-10-28 | 2014-10-28 | Online monitor of propofol in blood, and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108088886A (en) * | 2016-11-21 | 2018-05-29 | 中国科学院大连化学物理研究所 | A kind of apparatus and method for quickly distinguishing different aviation oil products |
| CN117434292A (en) * | 2023-11-27 | 2024-01-23 | 苏州邦伊医疗科技有限公司 | Real-time continuous detecting instrument and equipment based on propofol blood concentration in blood |
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| US20030201388A1 (en) * | 2000-11-17 | 2003-10-30 | Saes Getters S.P.A. | Method for measuring the concentration of nitrogen in argon by means of ion mobility spectrometry |
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| CN103884771A (en) * | 2012-12-21 | 2014-06-25 | 中国科学院大连化学物理研究所 | Accurate method for detecting propofol anesthetic in blood |
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2014
- 2014-10-28 CN CN201410587876.0A patent/CN105628779A/en active Pending
Patent Citations (6)
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| US20030201388A1 (en) * | 2000-11-17 | 2003-10-30 | Saes Getters S.P.A. | Method for measuring the concentration of nitrogen in argon by means of ion mobility spectrometry |
| CA2635781A1 (en) * | 2006-01-02 | 2007-07-12 | Excellims Corporation | Multi-dimensional ion mobility spectrometry apparatus and methods |
| CN102455318A (en) * | 2010-10-29 | 2012-05-16 | 中国科学院大连化学物理研究所 | Continuous monitor for detecting aerosol sample |
| CN103299184A (en) * | 2010-10-29 | 2013-09-11 | Atonarp株式会社 | Analysis apparatus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108088886A (en) * | 2016-11-21 | 2018-05-29 | 中国科学院大连化学物理研究所 | A kind of apparatus and method for quickly distinguishing different aviation oil products |
| CN117434292A (en) * | 2023-11-27 | 2024-01-23 | 苏州邦伊医疗科技有限公司 | Real-time continuous detecting instrument and equipment based on propofol blood concentration in blood |
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Application publication date: 20160601 |