CN105616963A

CN105616963A - Preparation method of side-reaction-resistant pharmaceutical powder for postoperative patients with tumor

Info

Publication number: CN105616963A
Application number: CN201610117212.7A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-04-12
Filing date: 2014-04-12
Publication date: 2016-06-01
Also published as: CN103919995A; CN105582301A

Abstract

The invention discloses a preparation method of side-reaction-resistant pharmaceutical powder for postoperative patients with tumor. The side-reaction-resistant pharmaceutical powder is prepared from, by weight, 15 parts of astragalus membranaceus, 10 parts of rhizoma atractylodis macrocephalae (stir-baking with bran), 4 parts of white paeony roots, 9 parts of red-rooted salvia roots, 8 parts of magnolia obavata, 4 parts of rheum officinale, 8 parts of colla corii asini, 5 parts of indigo naturalis, 11 parts of rhizoma anemarrhenae, 6 parts of rhizoma cyperi (vinegar), 10 parts of radix polygonati officinalis, 9 parts of costus roots, 6 parts of herba eupatorii, 5 parts of fructus gardeniae (stir-fried) and 8 parts of rhizoma pinelliae. According to the preparation method, selected materials are all traditional Chinese medicine materials, and no toxic or side effect exists; the medical materials are easy to obtain, medicine cost is low, and no burden is caused to the patients.

Description

The preparation method of the anti-side reaction medicament pulvis of tumour patient after art

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to the anti-side reaction medicament of tumour patient and preparation method after a kind of art.

Background technology

Chemotherapy is current tumour, a kind of therapeutic modality that especially malignant tumor patient the most extensively adopts. Its principle is: utilize chemicals to kill tumour cell, the growth and breeding of inhibition tumor cell and the differentiation of promotion tumour cell. Radiotherapy, i.e. radiation treatment are one of big treatment meanss of cancer three. It is by the radiation exposure tumour of various different-energy, to suppress and to kill a kind of methods for the treatment of of cancer cells. Radiotherapy chemotherapy can be used alone, it is also possible to partner treatment, and as a part for complex therapy, Radiotherapy chemotherapy can improve the curative ratio of tumour. But Radiotherapy chemotherapy belongs to the scope of " sending an expedition against ", often there is attacking the situation that evil wound is positive, Radiotherapy chemotherapy treatment tumour is while killing tumor cell, also normal cell and immunity (opposing) cell are together killed, so being the methods for the treatment of of a kind of " destruction of all people good and bad alike ", therefore Radiotherapy chemotherapy over the course for the treatment of more there are some more serious toxic side effecties, and human body is very harmful.

The side reaction of Radiotherapy chemotherapy shows as:

1. health is weak: patient there will be health fatigue and weak after accepting Radiotherapy chemotherapy, goes out abnormal sweating, drowsiness malaise symptoms of Denging.

2. lower immune function: great majority have the chemotherapeutics of antitumor action that the immunologic function of patient is had restraining effect,

The lower immune function of patient is caused after chemotherapy.

3. gastricism: a lot of chemotherapeutics causes a series of symptoms by the mucous membrane in stimulating gastrointestinal road, such as appetite decline, dietary amount minimizing, Nausea and vomiting, abdominal distension, stomachache, diarrhoea or constipation etc.

4. neural system toxin: mainly after accepting chemotherapy, peripheral terminals nerve is produced detrimental effect, the symptoms such as acroanesthesia can occur in patient, and acra is insensitive by chemotherapeutics.

5. skin abnormality: dry skin shows as skin pruritus, pigmentation and decortication, can produce permanent light brown spot. Wet property cutaneous manifestations, for irradiating position eczema, bubble, can cause erosion, break and burst time serious.

Malignant tumour belongs to the category of the traditional Chinese medical science " amassing ", " empty labor ", there is the performance of vital QI being weakened and pathogen being violent. And due to being continuous of the course of disease, the phenomenon of " chronic disease involving kidney " can be caused. After accepting Radiotherapy chemotherapy, disease that it is weakened body resistance is more obvious, causes because vigour is impaired further: One's spirits are drooping, malaise, the lazy language of speech dysphoria in chestpalms-soles, few etc. Hindering and then feel sick indigestion and loss of appetite in stomach, hinder in kidney then dizziness and tinnitus, dedentition is sent out de-, and soreness of waist foot is soft, hinders in the heart then shortness of breath and palpitation.

Publication number is CN101549154A(application number 200910031557.0) Chinese patent literature disclose a kind of by name " a kind of radioprotective and alleviate the nutritive medium of radiotherapy side effect ", this kind of nutritive medium adds carotene, chitosan, vitamins C, vitamin-E etc. by physiological saline and makes. Application publication number is CN103446206A(application number 201210184710.5) Chinese patent literature disclose a kind of by name " improving composition and the application of toxic side effects caused by malignant tumor patient chemotherapy ", said composition is by glossy ganoderma 5��200 parts, Radix Panacis Quinquefolii or ginseng 5��150 parts, fermented Cordyceps mycopowder 1��90 part and/or Cordyceps sinensis 1��120 part, or by the water of above-mentioned raw materials and/or what alcohol extract formed as active ingredient. Publication number is CN1357354A(application number 01114965.5) Chinese patent literature disclose a kind of by name " medicine for the treatment of concurrent chemoradiotherapy of malignant tumor side reaction and its preparation method ", it is made up of Radix Codonopsis, the Radix Astragali, Poria cocos, the bighead atractylodes rhizome, Glossy Privet Fruit, wolfberry fruit, burnt short, bristly hair or beard, Radix Glycyrrhizae.

In a word, traditional Chinese medicine achieves certain achievement in treatment Radiotherapy chemotherapy toxic side effects, but also there are some problems: existing oncotherapy preparation can not solve the toxic side effects of chemotherapy on human body well, to such an extent as to a lot of tumour patient has died from the toxic side effects of Radiotherapy chemotherapy over the course for the treatment of, therefore need to be improved further perfect.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide the anti-side reaction medicament of tumour patient after a kind of art, has easy operation, feature evident in efficacy, and its adopts Chinese medicinal materials comparatively common in the localities as raw material, with low cost.

The technical scheme of the present invention is:

The anti-side reaction medicament of tumour patient after art, takes off the main raw material stating weight proportion and is prepared from: Radix Astragali 20-30 part, the bighead atractylodes rhizome (bran stir-fry) 6-15 part, root of herbaceous peony 2-6 part, red sage root 6-12 part, river Piao's 4-12 part, rheum officinale 3-6 part, donkey-hide gelatin 5-12 part, indigo naturalis 3-6 part, wind-weed 7-15 part, rhizoma cyperi (vinegar) 4-8 part, radix polygonati officinalis 6-15 part, Radix Aucklandiae (Radix Vladimiriae) 6-12 part, eupatorium 3-9 part, cape jasmine (stir-fry) 3-6 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4-12 part.

The anti-side reaction medicament of tumour patient after art, it is preferable that scheme be take off the main raw material stating weight proportion and be prepared from: Radix Astragali 13-16 part, the bighead atractylodes rhizome (bran stir-fry) 8-12 part, root of herbaceous peony 3-5 part, red sage root 8-10 part, river Piao's 6-10 part, rheum officinale 3-5 part, donkey-hide gelatin 7-10 part, indigo naturalis 4-6 part, wind-weed 9-13 part, rhizoma cyperi (vinegar) 5-7 part, radix polygonati officinalis 8-12 part, Radix Aucklandiae (Radix Vladimiriae) 8-10 part, eupatorium 5-7 part, cape jasmine (stir-fry) 4-6 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7-9 part.

The anti-side reaction medicament of tumour patient after art, scheme more preferably is, takes off the main raw material stating weight proportion and is prepared from: the Radix Astragali 15 parts, the bighead atractylodes rhizome (bran stir-fry) 10 parts, the root of herbaceous peony 4 parts, the red sage root 9 parts, river Piao 8 parts, rheum officinale 4 parts, 8 parts, donkey-hide gelatin, indigo naturalis 5 parts, the wind-weed 11 parts, rhizoma cyperi (vinegar) 6 parts, radix polygonati officinalis 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, eupatorium 6 parts, cape jasmine (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

Present invention also offers and tumour patient anti-side reaction medicament after above-mentioned art is made pharmaceutically acceptable pulvis, aqua, paste, granule, tablet or capsule.

The preparation method of described pulvis is:

Preferably, (1) rheum officinale, indigo naturalis, donkey-hide gelatin are pulverized into fine powder respectively, cross 60-120 order sieve and (cross 85-115 order sieve; More preferably, 105 order sieves are crossed);

Preferably, (2) Radix Astragali, the bighead atractylodes rhizome (bran stir-fry), the root of herbaceous peony, the red sage root, river Piao, the wind-weed, rhizoma cyperi (vinegar), radix polygonati officinalis, Radix Aucklandiae (Radix Vladimiriae), eupatorium, cape jasmine (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding are crossed 85-135 order sieve and (crosses 100-120 order sieve; More preferably, 110 order sieves are crossed);

(3) step (1) and (2) gained are mixed even.

The preparation method of described aqua is:

(2) Radix Astragali, the bighead atractylodes rhizome (bran stir-fry), the root of herbaceous peony, the red sage root, river Piao, the wind-weed, rhizoma cyperi (vinegar), radix polygonati officinalis, Radix Aucklandiae (Radix Vladimiriae), eupatorium, cape jasmine (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, adding water, (water consumption is that doubly (preferred, 3-4 is doubly for the 2.5-4.5 of bulk drug gross weight; More preferably, 3.5 times)) decoct and boil 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; More preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; More preferably, 1.0 hours), filtrate merges, and lets cool;

(3) rheum officinale after step (1) pulverizing, indigo naturalis and donkey-hide gelatin are added step (2) gained liquid, sterile packaged.

The preparation method of described paste is:

(1) rheum officinale, indigo naturalis, donkey-hide gelatin are pulverized into fine powder respectively, cross 60-120 order sieve (preferred, to cross 85-115 order sieve, more preferably, cross 105 order sieves);

(2) Radix Astragali, the bighead atractylodes rhizome (bran stir-fry), the root of herbaceous peony, the red sage root, river Piao, the wind-weed, rhizoma cyperi (vinegar), radix polygonati officinalis, Radix Aucklandiae (Radix Vladimiriae), eupatorium, cape jasmine (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, adding water, (water consumption is that doubly (preferred, 3-4 is doubly for the 2.5-4.5 of bulk drug gross weight; More preferably, 3.5 times)) decoct and boil 2 times, 1.2-2.4 hour first time (preferred, 1.5-2.0 hour; More preferably, 1.8 hours), second time 0.8-1.2 hour (preferred 0.9-1.1 hour; More preferably, 1.0 hours), filtrate merges, and filters, concentrated that relative density is 1.36-1.38(48 DEG C) clear cream;

(3) rheum officinale after step (1) pulverizing, indigo naturalis and donkey-hide gelatin are added the clear cream of step (2) gained, sterile packaged.

The preparation method of described granule is:

Preferably, (3) qinghuo reagent 0.8-1.2 part (0.9-1.1 part; More preferably, 1.0 parts), sucrose 1.5-3.5 part (preferred, 2-3 part; 2.5 parts more preferably), and dextrin 0.8-1.2 part (preferred, 0.9-1.1 part; More preferably, 1.0 parts), add step (1) gained rheum officinale, indigo naturalis and donkey-hide gelatin fine powder after mixing, mixed even, make particle, dry, obtain granule.

Preferably, the preparation method of described tablet is: by claim 5 gained medicament pulvis according to 0.3-0.5g/ sheet (0.35-0.45g/ sheet; More preferably, 0.4g/ sheet) metering, the tablet dosage form of circle or other shapes it is pressed into according to the preparation for processing of tablet.

Preferably, the preparation method of described capsule is: by claim 5 gained medicament pulvis according to 0.4-0.6g/ grain (0.45-0.55g/ grain; More preferably, 0.5g/ grain) metering, it is processed into capsule shape formulation according to the preparation for processing of capsule.

The pharmacology of the present invention's main Chinese medicine material used is as follows:

The Radix Astragali: nature and flavor: taste is sweet, temperature. Gui Jing: return lung, the spleen channel. Effect: benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration by strengthening QI. Curing mainly: the card of all deficiency of vital energy anemia, such as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, prolapse of the anus, uterine prolapse, spontaneous perspiration, night sweat, oedema, blood-arthralgia, ulcer difficulty is burst or is burst for a long time and do not hold back.

The bighead atractylodes rhizome (bran stir-fry): nature and flavor: bitter, sweet, temperature. Gui Jing: return spleen, stomach warp. Effect: invigorating the spleen and benefiting QI, eliminating dampness Li Shui, only sweat, antiabortive. Cure mainly: deficiency-weakness of spleen-QI weak, the few abdominal distension of food, constipation of having loose bowels, the dysuria of fluid-retention stagnating in the interior, oedema, dizziness due to fluid-retention, cold-dampness numbness, bodily pain, spontaneous sweating due to deficiency of QI, threatened abortion.

The root of herbaceous peony: nature and flavor: bitter, acid, micro-cold. Gui Jing: return liver, the spleen channel. Effect: joint venture of nourishing blood, relieving spasm to stop pain, holds back high and level tone liver. Curing mainly: deficiency of blood fever and chills, epigastric pain, hypochondriac pain, limb spasm pain, dysmenorrhoea, menoxenia, uterine bleeding, spontaneous perspiration, night sweat, lower dysentery is had loose bowels, and has a headache dizzy.

The red sage root: nature and flavor: bitter, micro-cold. Gui Jing: the thoughts of returning home, pericardium, Liver Channel. Effect: promoting blood circulation to remove blood stasis, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, and cool blood disappears carbuncle. Curing mainly: menoxenia, dysmenorrhoea, through closing, stomachache of being retarded by silt postpartum, trusted subordinate's pain, lump in the abdomen is gathered, and hot numbness swells and ache, wound, and heat enters ying blood, haves the fidgets, vexed insomnia, carbuncle pyogenic infections from tumour or sore.

River Piao: nature and flavor: bitter, pungent, warm in nature. Gui Jing: return spleen, stomach large intestine channel. Effect: promoting the circulation of qi disappears long-pending, eliminating dampness removes mite, lowering the adverse QI to relieve asthma. Curing mainly: stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity ruffian is vomited and diarrhoea, and phlegm stops up the circulation of vital energy in the wrong direction, breathes with cough.

Rheum officinale: nature and flavor: bitter, cold. Gui Jing: stomach, large intestine, liver, the spleen channel. Effect: attack stagnant, clearing away damp-heat, purging intense heat, cool blood, the stasis of blood of dispelling, removing toxic substances. Cure mainly: real accumulation and constipation, the thermojunction feeling of stuffiness in chest; Damp-heat dysentery, jaundice, gonorrhoea, oedema abdomen is full, dysuria; Hot eyes, swelling and pain in the throat, ulceration on the oral mucosa and the tongue, gastropyretic vomiting, spits blood, spitting of blood, and bleeding from five sense organs or subcutaneous tissue, has blood in stool, hematuria; Storing blood, through closing, stomachache of being retarded by silt postpartum, lump in the abdomen is gathered, wound, and heat poison large carbuncle, erysipelas, scalds.

Donkey-hide gelatin: nature and flavor: taste is sweet is flat. Gui Jing: return liver, lung, kidney channel. Effect: hemostasis of enriching blood, nourishing Yin and moistening lung. Curing mainly: dizziness due to deficiency of blood, spit blood, bleeding from five sense organs or subcutaneous tissue, has blood in stool, bloody flux, gestation hemorrhage, uterine bleeding, and dysphoria is had a sleepless night, deficiency syndrome of the lung cough caused by dryness.

Indigo naturalis: nature and flavor: taste is salty, cold. Gui Jing: return liver, lung, stomach warp. Effect: heat-clearing, cool blood, removing toxic substances. Curing mainly: temperature poison macula, spit blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, pediatric epilepsy scared, liver-fire invading the lung is coughed, swelling and pain in the throat, erysipelas, mumps, and sore swells, snake bite and insect sting.

The wind-weed: nature and flavor: bitter, cold. Gui Jing: return lung, stomach, kidney channel. Effect: heat-clearing and fire-purging, nourshing Yin and drynsessmoistening prescription. Curing mainly: the hot polydipsia of febrile disease height, cough due to lung-heat, hectic fever due to yin hectic fever, seminal emission, night sweat, restlessness of asrhenia type and insomnia, quenches one's thirst.

Rhizoma cyperi (vinegar): nature and flavor: taste hardship pungent, sweet, micro-, flat. Gui Jing: return liver, three burnt warps. Effect: regulate the flow of vital energy Xie Yu, menstruation regulating is antiabortive. Cure mainly: the distending pain over the hypochondrium, distending pain of the breast, hernia pain, menoxenia, the full pain of gastral cavity abdomen ruffian, belch acid regurgitation, evil of vomitting, dysmenorrhea, under uterine bleeding band, threatened abortion.

Radix polygonati officinalis: nature and flavor: taste is sweet, flat. Gui Jing: attach to the lung and stomach meridians. Effect: nourishing Yin and moistening lung, nourishing the stomach to promote the production of body fluid. Curing mainly: cough caused by dryness, labor is coughed, pyreticosis the moon wound, and dry throat is thirsty, quenches one's thirst, deficiency of Yin diseases caused by external factors, dizzy dizzy, muscle arteries and veins contraction pain.

Radix Aucklandiae (Radix Vladimiriae): nature and flavor: taste is pungent, bitter, temperature. Gui Jing: return lung, liver, the spleen channel. Effect: promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach. Curing mainly: chest abdominal distention and pain, vomiting, has loose bowels, and dysentery is tenesmus.

Eupatorium: nature and flavor: taste is pungent, flat. Gui Jing: return spleen, stomach warp. Effect: expelling summer-heat and damp, be amusing and in. Cure mainly: summer-heat and damp or damp-warm syndrome from the beginning of, generate heat nose heave, abdominal distension uncomfortable in chest, gastral cavity ruffian is not hungry, nausea and vomiting, sweet greasy in mouth, quenches one's thirst.

Cape jasmine (stir-fry): nature and flavor: bitter, cold. Gui Jing: the thoughts of returning home, liver, lung, stomach, three burnt warps. Effect: purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body. Curing mainly: pyreticosis is vexed, irascibility hot eyes, headache, jaundice due to damp-heat, drench card, spit blood, bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, ulceration on the oral mucosa and the tongue, sore swollen toxin, sprains and swells and ache.

Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): nature and flavor: taste is pungent, warm. Gui Jing: return spleen, stomach, lung channel. Effect: stopping nausea and vomiting by lowering the adverse flow of QI. Cure mainly: vomiting gastric disorder causing nausea, chest gastral cavity ruffian is vexed, globus hystericus.

Medicament of the present invention, based on traditional Chinese medical herbal treatment Radiotherapy chemotherapy side reaction principle, is make on the basis that have studied lot of documents, pharmacology work and clinical trial. Selected materials of the present invention is traditional Chinese medicine material, without any side effects, and this medicament is completely according to the body and mind feature of Chinese materia medica principle and tumour patient, and the side reaction caused by Radiotherapy chemotherapy has good result for the treatment of.

Embodiment

The technical scheme of the present invention is described in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.

The anti-side reaction medicament of tumour patient after embodiment 1 art, takes off the main raw material stating weight proportion and is prepared from (every part of 10g): the Radix Astragali 15 parts, the bighead atractylodes rhizome (bran stir-fry) 10 parts, the root of herbaceous peony 4 parts, the red sage root 9 parts, river Piao 8 parts, rheum officinale 4 parts, 8 parts, donkey-hide gelatin, indigo naturalis 5 parts, the wind-weed 11 parts, rhizoma cyperi (vinegar) 6 parts, radix polygonati officinalis 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, eupatorium 6 parts, cape jasmine (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

After above-mentioned art, the preparation method of the anti-side reaction medicament pulvis of tumour patient is:

(1) rheum officinale, indigo naturalis, donkey-hide gelatin are pulverized into fine powder respectively, cross 105 order sieves;

(2) Radix Astragali, the bighead atractylodes rhizome (bran stir-fry), the root of herbaceous peony, the red sage root, river Piao, the wind-weed, rhizoma cyperi (vinegar), radix polygonati officinalis, Radix Aucklandiae (Radix Vladimiriae), eupatorium, cape jasmine (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) co-grinding are crossed 110 order sieves;

(3) step (1) and (2) gained are mixed even.

Pulvis instructions of taking of the present invention: pulvis divides 5g/ bag, adopts every day 2-3 time, each one bag, with warm boiled water, and 7 days courses for the treatment of.

Model case one Jiang XX, age: 45 years old, sex: man. In August, 2009 makes carcinoma of gastric cardia Palliative surgery art in hospital, accept chemotherapy to alleviate slight illness after art always, chemotherapy causes following discomfort reaction: appetite is low, malaise and with nausea and vomiting phenomenon, what lassitude, does and all has no spirit, and patient once took the medicine of anti-chemotherapy side effect, without obvious result for the treatment of, seriously have impact on orthobiosis. Take the anti-side reaction medicament of tumour patient after the present embodiment gained art, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of. Taking 21 days, patient's appetite strengthens to some extent, and malaise symptoms is alleviated; Taking 2 months, patients ' vomiting phenomenon disappears, and spirit, muscle power obviously strengthen; Continuing to take two months, malaise symptoms completely dissolve, patient's self-induction is fully recovered.

The anti-side reaction medicament of tumour patient after embodiment 2 art, takes off the main raw material stating weight proportion and is prepared from (every part of 20g): the Radix Astragali 15 parts, the bighead atractylodes rhizome (bran stir-fry) 10 parts, the root of herbaceous peony 4 parts, the red sage root 9 parts, river Piao 8 parts, rheum officinale 4 parts, 8 parts, donkey-hide gelatin, indigo naturalis 5 parts, the wind-weed 11 parts, rhizoma cyperi (vinegar) 6 parts, radix polygonati officinalis 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, eupatorium 6 parts, cape jasmine (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

After above-mentioned art, the preparation method of the anti-side reaction medicament paste of tumour patient is:

(2) Radix Astragali, the bighead atractylodes rhizome (bran stir-fry), the root of herbaceous peony, the red sage root, river Piao, the wind-weed, rhizoma cyperi (vinegar), radix polygonati officinalis, Radix Aucklandiae (Radix Vladimiriae), eupatorium, cape jasmine (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water 3.5 times of bulk drug gross weight (water consumption be) decoct and boil 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, filter, concentrated that relative density is 1.36-1.38(48 DEG C) clear cream;

Paste instructions of taking of the present invention: paste adopts every day 2 times, each 8-10g, takes according to the ratio bath of 1:10,7 days courses for the treatment of.

Model case two poplar XX, age: 65 years old, sex: female. Primary hepatic carcinoma rupture in 2008, acute disease is cut open the belly, and excision cancer block, treats residual cancer by the method for chemotherapy afterwards, and patient's readme chemotherapy can cause some side reactions, mainly contains: tired, hypoimmunity, poor appetite, acra are insensitive, One's spirits are drooping. Taking the anti-side reaction medicament paste of tumour patient after the present embodiment gained art, adopt every day 2 times, each 10g, takes according to the ratio bath of 1:10,7 days courses for the treatment of. Taking 15 days, patient's mental status takes a turn for the better, and appetite strengthens to some extent; Taking 1 month, immunizing power improves, and malaise symptoms disappears gradually; Continue to take 2 months, any discomfort does not occur when patient takes, self-induction malaise symptoms completely dissolve.

The anti-side reaction medicament of tumour patient after embodiment 3 art, takes off the main raw material stating weight proportion and is prepared from (every part of 30g): the Radix Astragali 15 parts, the bighead atractylodes rhizome (bran stir-fry) 10 parts, the root of herbaceous peony 4 parts, the red sage root 9 parts, river Piao 8 parts, rheum officinale 4 parts, 8 parts, donkey-hide gelatin, indigo naturalis 5 parts, the wind-weed 11 parts, rhizoma cyperi (vinegar) 6 parts, radix polygonati officinalis 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, eupatorium 6 parts, cape jasmine (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

After above-mentioned art, the preparation method of the anti-side reaction pharmacy particle agent of tumour patient is:

(3) qinghuo reagent 1.0 parts, sucrose 2.5 parts, 1.0 parts, dextrin, adds step (1) gained rheum officinale, indigo naturalis and donkey-hide gelatin fine powder after mixing, mixed even, makes particle, dry, obtains granule.

Granule instructions of taking of the present invention: granule is divided 10g/ bag, every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.

Model case three king XX, age: 70 years old, sex: man. Patient does stomach resecting operation, does chemotherapy afterwards always and treats, and there will be following malaise symptoms: lassitude after each chemotherapy of patient's readme, and without appetite, malaise, skin abnormality is dry, drowsiness etc. Take the anti-side reaction pharmacy particle agent of tumour patient after the present embodiment gained art, adopt every day 3 times, each 1 one bags, with warm boiled water, 7 days courses for the treatment of. Taking 10 days, patient's appetite strengthens to some extent, and malaise symptoms improves gradually; Taking 1 month, patient's muscle power strengthens, and the mental status obviously takes a turn for the better; Continuing to take 2 months, malaise symptoms disappears.

The anti-side reaction medicament of tumour patient after embodiment 4 art, takes off the main raw material stating weight proportion and is prepared from (every part of 40g): the Radix Astragali 15 parts, the bighead atractylodes rhizome (bran stir-fry) 10 parts, the root of herbaceous peony 4 parts, the red sage root 9 parts, river Piao 8 parts, rheum officinale 4 parts, 8 parts, donkey-hide gelatin, indigo naturalis 5 parts, the wind-weed 11 parts, rhizoma cyperi (vinegar) 6 parts, radix polygonati officinalis 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, eupatorium 6 parts, cape jasmine (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

After above-mentioned art, the preparation method of the anti-side reaction medicament tablet of tumour patient is:

(3) step (1) and (2) gained are mixed even pulvis;

(4) by step (3) gained pulvis according to the metering of 0.4g/ sheet, the tablet dosage form of circle or other shapes it is pressed into according to the preparation for processing of tablet.

Tablets method of the present invention: tablet adopts every day 3 times, each 5-8 sheet, with warm boiled water, 7 days courses for the treatment of.

Model case four Wu XX, age: 63 years old, sex: man. After the right Mandible Malignant Tumor art of patient 10 years, in March, 2007 is at hospital diagnosis, there is a solitary sick point in the right lung middle period, patient coughs, pectoralgia, is diagnosed as lung cancer metastasis, undergos surgery afterwards, slight illness is alleviated by chemicotherapy, but chemicotherapy causes a series of discomfort reaction: acroanesthesia, whole body fatigue and weak, appetite are low, drowsiness after art. Take the anti-side reaction medicament tablet of tumour patient after the present embodiment gained art, adopt every day 3 times, each 8, with warm boiled water, 7 days courses for the treatment of. Taking 7 days, patient's malaise symptoms alleviates to some extent, and food of receiving is gradually many; Taking 2 months, malaise symptoms disappears gradually, and spirit, muscle power obviously strengthen; Continuing to take two months, patient's self-induction is fully recovered.

The anti-side reaction medicament of tumour patient after embodiment 5 art, takes off the main raw material stating weight proportion and is prepared from (every part of 50g): the Radix Astragali 15 parts, the bighead atractylodes rhizome (bran stir-fry) 10 parts, the root of herbaceous peony 4 parts, the red sage root 9 parts, river Piao 8 parts, rheum officinale 4 parts, 8 parts, donkey-hide gelatin, indigo naturalis 5 parts, the wind-weed 11 parts, rhizoma cyperi (vinegar) 6 parts, radix polygonati officinalis 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, eupatorium 6 parts, cape jasmine (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

After above-mentioned art, the preparation method of the anti-side reaction drug capsule agent of tumour patient is:

(3) step (1) and (2) gained are mixed even pulvis;

(4) by step (3) gained pulvis according to the metering of 0.5g/ grain, it is processed into capsule shape formulation according to the preparation for processing of capsule.

Capsule instructions of taking of the present invention: capsule adopts every day 3 times, each 6-10 grain, with warm boiled water, 7 days courses for the treatment of.

Model case five side XX, age: 49 years old, sex: female. In May, 2007 has a stomach upset, the swollen greatly thing of egg is had from touching epigastrium, gastroscopy pathology confirms malignant lymphoma of stomach, chemicotherapy is accepted to reduce slight illness after art, but chemicotherapy causes the malaise symptoms such as nausea and vomiting, poor appetite, tired, the hypoimmunity of spirit, took the medicine of many anti-chemotherapy side effects, all without positive effect. Taking the anti-chemotherapy side effect medicament of tumour patient after the present embodiment gained art, adopt every day 3 times, each 10, take 14 days, patient's malaise symptoms alleviates, and appetite strengthens; Taking 1 month, patient's malaise symptoms disappears gradually, and the mental status takes a turn for the better, and muscle power strengthens; Continuing to take 2 months, patient's self-induction is without malaise symptoms.

The anti-side reaction medicament of tumour patient after embodiment 6 art, takes off the main raw material stating weight proportion and is prepared from (every part of 60g): the Radix Astragali 15 parts, the bighead atractylodes rhizome (bran stir-fry) 10 parts, the root of herbaceous peony 4 parts, the red sage root 9 parts, river Piao 8 parts, rheum officinale 4 parts, 8 parts, donkey-hide gelatin, indigo naturalis 5 parts, the wind-weed 11 parts, rhizoma cyperi (vinegar) 6 parts, radix polygonati officinalis 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, eupatorium 6 parts, cape jasmine (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts.

After above-mentioned art, the preparation method of the anti-side reaction medicament aqua of tumour patient is:

(2) Radix Astragali, the bighead atractylodes rhizome (bran stir-fry), the root of herbaceous peony, the red sage root, river Piao, the wind-weed, rhizoma cyperi (vinegar), radix polygonati officinalis, Radix Aucklandiae (Radix Vladimiriae), eupatorium, cape jasmine (stir-fry) and Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) are placed in marmite, add water 3.5 times of bulk drug gross weight (water consumption be) decoct and boil 2 times, 1.8 hours first times, second time 1.0 hours, filtrate merges, and lets cool;

Aqua instructions of taking of the present invention: aqua adopts every day 2 times (warm), each 300-500ml, 7 days courses for the treatment of.

The clinical application of the anti-side reaction medicament aqua of tumour patient after test example 1 embodiment 6 gained art: in May ,-2012 in July, 2008,8 hospital's screening 200 example patients, wherein women 96 examples, the male sex 104 example. Before test 2 weeks, this crowd being observed continuously, record symptom and change, be divided into two groups, experimental group and control group at random, and experimental group takes embodiment 6 products obtained therefrom, and control group takes other medicine (the conventional medicine such as safe peace oral liquid, selenium Wei Kang). Using method is: taking every day twice (warm), each 300m1-500m1(adjusts to some extent depending on particular case), 7 days courses for the treatment of. Curative effect situation criterion: cure: take a course for the treatment of of this product, malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: to take a course for the treatment of of this product, malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: taking a course for the treatment of of this product, malaise symptoms is unchanged. Result is as shown in table 1.

Table 1: take the checking of embodiment 6 products obtained therefrom result for the treatment of

Result for the treatment of: cure 72 examples (72%), effective 26 examples (26%), invalid 2 examples (2%), always have efficiency 98%. Successful is better than control group.

During taking, self-induction symptom and muscle power psychic changes thereof are as shown in table 2.

Table 2:

As shown in Table 2: take 10 days, the patient of more than 52% feels to take a turn for the better to some extent, and malaise symptoms improves; Taking 20 days, the patient of more than 73% feels to take a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Taking 30 days, more than 96% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and part patient's self-induction is fully recovered. Experimental group is taken more than 30 days, has efficiency can reach 94%, and control group is only 75%.

Finally it should be noted that, embodiment is the embodiment of optimum of the present invention, it is not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, technical scheme described in foregoing embodiments still can be modified by it, or wherein part technology feature carries out equivalent replacement. Within the spirit and principles in the present invention all, any amendment of doing, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. the preparation method of the anti-side reaction medicament pulvis of tumour patient after art, is characterized in that, take off the main raw material stating weight proportion and be prepared from: the Radix Astragali 15 parts, the bighead atractylodes rhizome (bran stir-fry) 10 parts, the root of herbaceous peony 4 parts, the red sage root 9 parts, river Piao 8 parts, rheum officinale 4 parts, 8 parts, donkey-hide gelatin, indigo naturalis 5 parts, the wind-weed 11 parts, rhizoma cyperi (vinegar) 6 parts, radix polygonati officinalis 10 parts, Radix Aucklandiae (Radix Vladimiriae) 9 parts, eupatorium 6 parts, cape jasmine (stir-fry) 5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 parts; Step is,

(3) step (1) and (2) gained are mixed even.