CN105616184B - A kind of hyaluronic acid peptide bond object plane film and preparation method thereof - Google Patents
A kind of hyaluronic acid peptide bond object plane film and preparation method thereof Download PDFInfo
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- CN105616184B CN105616184B CN201410591484.1A CN201410591484A CN105616184B CN 105616184 B CN105616184 B CN 105616184B CN 201410591484 A CN201410591484 A CN 201410591484A CN 105616184 B CN105616184 B CN 105616184B
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- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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Abstract
The invention discloses a kind of hyaluronic acid peptide bond object plane films, are calculated by mass percentage, contain following components：0.1~20 part of hyaluronic acid peptide bond object, 0.1~10.0 part of skin whitening agent, 2.0~20.0 parts of emulsifier, 0.5~20.0 part of keratolytic, 1.0~15.0 parts of external skin wrinkling-preventing agent, 0.1~5.0 part of aromatic, 0.1~10.0 part of glycerine, surplus is water.Comprising with moisturizing, whitening, nti-freckle, smoothing wrinkle, the peptide growth factor for repairing scar in the mask composition of the present invention, such as fibroblast growth factor, epidermal growth factor, vascular endothelial growth factor etc., these peptide growth factors, it is bonded with micromolecule hyaluronic acid, it is released by reversible chemical bond and is absorbed by facial skin in use, long action time, cosmetic result are apparent.
Description
Technical field
The present invention relates to skin care field, specially a kind of hyaluronic acid peptide bond object plane film and preparation method thereof.
Background technology
Facial mask is a kind of currently used cosmetology product, and principle was passed through using the of short duration time for being covered in face
It is temporarily isolating extraneous air and pollution, improves skin temperature, the pore expansion of skin promotes sweat gland secretion and metabolism,
So that the oxygen content of skin is increased, is conducive to the oil substances that skin excludes the product and accumulation of epidermal cell metabolism, face
Moisture content in film penetrates into the cuticula of skin epidermis, and skin becomes soft, naturally bright with elasticity, reaches beautifying and anti-aging
Effect.Facial mask type on domestic market is very more, the various composition in facial mask, such as hyaluronic acid, superoxide dismutase
The substances such as enzyme, fibroblast growth factor impart crease-resistant facial mask whitening antioxygen, moisturizing moisturizing, Firm, sensitive skin, whitening
Moisturizing, moisturizing isolation and other effects, thus liked by numerous people seeking beauties.
Hyaluronic acid also known as sodium hyaluronate are a kind of acid mucopolysaccharides.It is the tender important foundation substance of skin water, itself
It is also a kind of ingredient of human body, there is special water retention, deal to be more up to 100 times of itself weight for it, such as：2%
The water-soluble liquid energy of pure hyaluronic acid firmly hold 98% moisture.It is the substance that moisture retention is best in presently found nature,
It is referred to as ideal natural moisturizing factor (Natural moisturizing factor, NMF).Coordinate with other nutritional ingredients
It uses, the more preferable effect for promoting nutrient absorption can be played.Hyaluronic acid is existed with its unique molecular structure and physicochemical property
Show that a variety of important physiological functions, such as lubricating joint adjust the permeability of vascular wall, regulatory protein matter, water power in body
Matter diffusion and operating are solved, wound healing etc. is promoted.Macromolecular hyaluronic acid (molecular weight ranges 1 800 000~2,200 000) can
One layer of ventilative film is formed in skin surface, skin smooth is made to moisten, and alien bacteria, dust, ultraviolet light can be obstructed and invaded
Enter, protects the skin from infringement；Middle molecular weight hyaluronic acid (molecular weight ranges 1 000 000~1 800 000) can be compacted flesh
Skin, permanent moisturizing；Micromolecule hyaluronic acid (molecular weight ranges 400 000~1 000 000) can penetrate into corium, have slight expand
Capillary is opened, increases blood circulation, improves intermediate supersession, promotes skin-nourishing absorption, have the function of stronger wrinkle-chasing,
Skin elasticity, delay skin aging can be increased.
Palmityl tetrapeptide (Palmitoyl tetrapeptide-3) is a kind of peptide by 4 Amino acid synthesis, widely
In beauty product and cosmetics, it is possible to reduce the generation of interleukins diminishes inflammation, to by anti-inflammatory antioedematous come
Achieve the purpose that anti crease and anti senile old.
Acetic acid M peptides/palmitic acid SymPeptide Matrixyl Acetate/ (Palmitoyl Pentapeptide), for synthesis
Collagen predecessor, can inhibit the generation of metalloprotein amylase, and promote collagen synthesis, act on skin corium
Elastin laminin restore skin elastic.It is effectively improved wrinkle, reproduces smooth resilient skin quality.With apparent anti-aging effects.
Acetyl group hexapeptide/Argireline Acetyl hexapeptide-3, the class Rou Du Rod being composed of six Amino acids
Bacteria factor, the class that is otherwise known as Rou Du Rod rhzomorphs can inhibit nerve conduction, reduce contraction of muscle, prevent expression line, dynamic line
It is formed.It is a kind of biologically active polypeptide, has moisturizing, reduces existing facial wrinkles, and new wrinkle can be effectively prevent to produce
It is raw, there are apparent anti-aging effects.
Fibroblast growth factor (fi-broblast growth factors, FGFs), fibroblast growth factor
It is a kind of multifunctional powerful cell factor, to promoting fibroblastic metabolism and the formation of collagen to play important work(
Can, synthesis and the cell metabolism of the protein of Skin Cell can be enhanced, with delaying skin cell ageing, promote epidermal cell
Reparation and growth, keep skin smooth plump.It is divided into acid fibroblast growth factor and basic fibroblast life
The long factor.Acid fibroblast growth factor (acid fibro-blast growth factor, aFGF), i.e. aFGF, by
147 amino acid compositions, molecular weight are the active peptides of 15.3KD.It is original thin to substitute to promote the generation of neoblast
Born of the same parents improve microcirculation to accelerate the metabolism of pigment, to reach desalination color to reduce melanin and coloured corpuscle content in skin
Plain and ruddy skin effect.By skin renewal, epidermal elasticity, supplement skin-nourishing three approach is promoted to play and prevent and dispel
The effect of wrinkle.To acne of dispelling, color spot of dispelling, brighten, improve skin elasticity, damage skin repair effectively up to 95%, to skin gloss,
It moistens, is soft, subtracting wrinkle etc. effectively up to 93%.Basic fibroblast growth factor (base fibro-blast growth
Factor, bFGF) bFGF is the polypeptide containing 155 amino acid.Senile cell can be updated, to mitigate the heavy of skin pigment
It, achievees the effect that whitening spot-removing.The microenvironment of cell growth can be improved, promote the synthesis of elastomer and collagen,
Make skin high resilience, skin is made to be in sliding tender state.It can promote fibroblastic growth and development, constantly with new thin
Born of the same parents replace aged cells, there is wrinkle resistant, anti-wrinkle effect.
Epidermal growth factor (EGF) is a kind of active material in human body, is made of 53 amino, it can stimulate epithelium
Cell and endothelial cell growth make new epidermal cell constantly grow up to, and dead skin layer is pushed and is gradually fallen off, and keep skin delicate
It is smooth.Collagen and collagen enzymatic synthesis, secretion Collagen material, hyaluronic acid and glycoprotein is promoted to adjust collagenous fibres, have and moisten
Skin, enhancing skin elasticity reduce wrinkle of skin and prevent the effect of skin aging.
Vascular endothelial growth factor (vascular endothelial growth factor, VEGF), is highly conserved
Homodimer glycoprotein.Two molecular weight are respectively that the single-stranded of 24kDa forms dimer with disulfide bond, and early stage is also referred to as blood vessel
P-F, energy vasoactive endothelial cell promote vascular endothelial cell proliferation, increase vasopermeability, can accelerate face
Blood circulation, exclude skin below toxin, enable nutrient enter skin, be fully absorbed by the skin, make skin become water it is tender,
It is smooth.The blood Rapid Circulation of face can play the role of the skin-active that wrinkles simultaneously, keep skin ruddy careful, remove the work(of acne nti-freckle
Effect.
Superoxide dismutase (Superoxide Dismutase, SOD), is a kind of active material derived from life entity,
Free radical can be removed, good guarantor is played to epidermal cell, sebaceous glands and subcutaneous fat, big eccrine gland, elastin and fiber
Shield acts on, and ensures being normally carried out for skin histology metabolism, makes skin smooth, exquisiteness, flexible, and reduce wrinkle.Thus
Can delay aging not only has the effects that crease-resistant, nti-freckle, depigmentaton, also anti-inflammatory, sun-proof, delay skin aging effect.
The nutritional ingredient contained in facial mask with advances in technology is also more and more, on the one hand these substances can give facial mask
Magical beauty functions are brought, but then, there is also many problem of allowing people to worry.Big point be added in such as facial mask
The natural collagen of son is difficult to be absorbed by the skin, and is not suitable for human skin and absorbs, water-soluble and permeability is also poor；Some in facial mask
Ingredient is unstable, and cosmetic result, anti-aging effects are not good enough, and the beautification function time is short；Facial mask cleaning effect is poor, and skin care ingredient cannot
Deep enough skin permeation, infiltration capacity is also seldom, is not suitable for the people for needing deep layer clean skin；Even added with a large amount of in some facial masks
Chemical preservative, and mineral composition content is more, being irritating to the skin property, and sensibility skin is to be not suitable for use, therefore
Need a kind of safe, non-stimulated and broad spectrum activity facial mask.
Invention content
The technical problem to be solved by the present invention is to overcome the existing defects, provides a kind of hyaluronic acid peptide bond object plane film
Preparation method, be calculated by mass percentage, formula contain following components：
0.1~20.0 part of hyaluronic acid peptide bond object, 0.1~10.0 part of skin whitening agent, emulsifier 2.0~20.0
Part, 0.5~20.0 part of keratolytic, 1.0~15.0 parts of external skin wrinkling-preventing agent, 0.1~5.0 part of aromatic, glycerine 0.1~10.0
Part, surplus is water.
Further, it is calculated by mass percentage, formula contains following components：
1.0~3.5 parts of hyaluronic acid peptide bond object, 2.5~5 parts of skin whitening agent, 8~12 parts of emulsifier, cutin is soft
1~4 part of agent, 3~5 parts of external skin wrinkling-preventing agent, 0.1~5 part of aromatic, 2~4 parts of glycerine, surplus is water.
Further, the hyaluronic acid peptide bond object refers to hyaluronic acid and fibroblast growth factor, epithelium
In growth factor, vascular endothelial growth factor, superoxide dismutase, palmityl tetrapeptide, palmitic acid SymPeptide, acetyl group hexapeptide
One or more of conjugation bondings and obtain, the hyaluronan molecule amount selects the ＜ for being easy to be absorbed by human epidermal
The micromolecule hyaluronic acid of 50KDa
Further, a kind of hyaluronic acid peptide bond object plane film, the skin whitening agent be vitamin C,
Any one or a few in Seabuckthorn Oil, tartaric acid, ascorbic acid, gallic acid, kojic acid, vitamin B3.
Further, the keratolytic lanolin, it is sunflower oil, grape seed oil, safflower oil, evening primrose oil, molten
Solve any one or a few in keratinase.
Further, the external skin wrinkling-preventing agent be niacin, niacinamide, D~pantothenic acid, in vitamin E any one or
It is several.
Further, the aromatic is salvia officianlis oil, Rosa Damascana, chamomile essential oil, Lavender, bergamot
Any one or a few in essential oil, lemon, Peppermint essential oil.
Further, the preparation method of the hyaluronic acid peptide bond object, to be 10 by 1.0~5.0g molecular weight,
000~30,000 hyaluronic acid is dissolved in 80~100ml PBS buffer solutions, and it is 7.0~8.0 to adjust pH, and addition 100~
The polypeptide of the open loop of 400mg sodium metaperiodates and 100~200mg, conjugation condensation reaction 8 hours, it is ensured that the reaction was complete；Gel chromatography is pure
After change, freeze-drying, nuclear magnetic resonance confirms.
The preparation method of the hyaluronic acid peptide bond object plane film, includes the following steps：
By 0.1~20 part of hyaluronic acid peptide bond object, 0.1~10 part of skin whitening agent, 2~20 parts of emulsifier, cutin
0.5~20 part of softening agent is added in ultra-pure water, and 40~50 DEG C stir evenly, spare；
(2) 1~15 part of external skin wrinkling-preventing agent, 0.1~5 part of aromatic, 0.1~10 part of glycerine are uniformly mixed, spare；
(3) it is added in the mixture that step (2) obtains, stirs when the mixture obtained by step (1) being cooled to 35 DEG C
Uniformly；
(4) ultra-pure water is added in the mixture obtained to step (3), until mixture gross mass is 100 parts.
The beneficial effects of the invention are as follows：
Include that there is moisturizing, whitening, nti-freckle, the peptide growth factor for repairing scar in the mask composition of the present invention, this
A little peptide growth factors, it is enough to anti-wrinkle, it slows down aging.In order to make growth factor be absorbed well by skin, by polypeptide with
Micromolecule hyaluronic acid is bonded, while reaching skin makeup, the water-retaining property of hyaluronic acid and its can penetrate into corium, have
Mild dilation capillary increases blood circulation, improves intermediate supersession, promotes skin-nourishing absorption, can reach relatively strong
Wrinkle-chasing function, to increase skin elasticity, and then the beauty functions of delay skin aging.Hyaluronic acid and albumen or polypeptide
The facial mask that peptide key compound makes is stablized relatively, is released by reversible chemical bond inhaled by facial skin in use
It receives, long action time, cosmetic result is apparent.
Description of the drawings
Attached drawing is used to provide further understanding of the present invention, and a part for constitution instruction, the reality with the present invention
It applies example to be used to explain the present invention together, not be construed as limiting the invention.In the accompanying drawings：
Fig. 1 is the nuclear-magnetism of acid fibroblast growth factor and hyaluronic acid bonding product in the embodiment of the present invention 4
Spectrogram knot；
Fig. 2 is the nuclear magnetic spectrogram of hyaluronic acid and palmitic acid SymPeptide key compound in the embodiment of the present invention 6.
Specific implementation mode
Hereinafter, preferred embodiments of the present invention will be described, it should be understood that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Embodiment 1
A kind of hyaluronic acid peptide bond object plane film, is calculated by mass percentage, contains following components：
0.1 part of hyaluronic acid and superoxide dismutase key compound, 10.0 parts of vitamin C agent, 2.0 parts of emulsifier, wool
0.5 part of fat, 1.0 parts of niacin, 5.0 parts of salvia officianlis oil, 10.0 parts of glycerine, surplus is water.
Embodiment 2
A kind of hyaluronic acid peptide bond object plane film, is calculated by mass percentage, contains following components：
20.0 parts of hyaluronic acid and palmityl tetrapeptide key compound, 0.1 part of Seabuckthorn Oil, 20.0 parts of emulsifier, sunflower oil
20.0 parts, 15.0 parts of niacinamide, 0.1 part of Rosa Damascana, 0.1 part of glycerine, surplus is water.
Embodiment 3
A kind of hyaluronic acid peptide bond object plane film, is calculated by mass percentage, contains following components：
10.0 parts of hyaluronic acid and vascular endothelial growth factor key compound, 5.0 parts of tartaric acid, 11.0 parts of emulsifier, grape pip
10.5 parts of oil, 8.0 parts of D~pantothenic acid, 2.5 parts of chamomile essential oil, 5.0 parts of glycerine, surplus is water.The facial mask has improvement microcirculation
The function of anti-red blood silk.
Wherein, the preparation process of hyaluronic acid and the key compound of vascular endothelial growth factor is：
The hyaluronic acid that 1.0g molecular weight is 30,000 is dissolved in 80ml PBS buffer solutions (1.25%, w/v), is adjusted
PH is 7.0, and 200mg sodium metaperiodate open loops are added, and the vascular endothelial growth factor of 100mg is added, and is conjugated condensation reaction 8 hours,
Ensure that the reaction was complete；After purification, freeze-drying, nuclear magnetic resonance confirms gel chromatography.
The preparation method of the hyaluronic acid vascular endothelial growth factor key compound facial mask, includes the following steps：
By 10.0 parts of hyaluronic acid and vascular endothelial growth factor key compound, 5.0 parts of tartaric acid, 11.0 parts of emulsifier, grape
10.5 parts of seed oil, is added in ultra-pure water, 40~50 DEG C stir evenly, spare；
(2) 8.0 parts of D~pantothenic acid, 2.5 parts of chamomile essential oil, 5.0 parts of glycerine are uniformly mixed, spare；
(3) it is added in the mixture that step (2) obtains, stirs when the mixture obtained by step (1) being cooled to 35 DEG C
Uniformly；
(4) ultra-pure water is added in the mixture obtained to step (3), until mixture gross mass is 100 parts.
Embodiment 4
A kind of hyaluronic acid peptide bond object plane film, is calculated by mass percentage, contains following components：
2.0 parts of hyaluronic acid and acid fibroblast growth factor key compound, 2.5 parts of ascorbic acid, 8 parts of emulsifier,
1 part of safflower oil, 3 parts of vitamin E, 0.1 part of Lavender, 2 parts of glycerine, surplus is water.The facial mask is that one kind is repaiied with deep layer
The facial mask of multiple function.
Wherein, the preparation process of hyaluronic acid and acid fibroblast growth factor key compound is：
The hyaluronic acid that 3.5g molecular weight is 20,000 is dissolved in 90ml PBS buffer solutions (3.9%, w/v), is adjusted
PH is 7.2, and 400mg sodium metaperiodate open loops are added, and the acid fibroblast growth factor of 200mg is added, and is conjugated condensation reaction 8
Hour, it is ensured that the reaction was complete；After purification, freeze-drying, nuclear magnetic resonance confirms gel chromatography.Acid fibroblast growth factor with thoroughly
The nuclear magnetic spectrogram of bright matter acid bonding product is as shown in Figure 1.
The preparation method of hyaluronic acid and acid fibroblast growth factor key compound facial mask, includes the following steps：
2.0 parts of hyaluronic acid and acid fibroblast growth factor key compound, 2.5 parts of ascorbic acid, 8 parts of emulsifier,
1 part of safflower oil is added in ultra-pure water, and 40~50 DEG C stir evenly, spare；
(2) 3 parts of vitamin E, 0.1 part of Lavender, 2 parts of glycerine are uniformly mixed, spare；
(3) it is added in the mixture that step (2) obtains, stirs when the mixture obtained by step (1) being cooled to 35 DEG C
Uniformly；
(4) ultra-pure water is added in the mixture obtained to step (3), until mixture gross mass is 100 parts.
Embodiment 5
A kind of hyaluronic acid peptide bond object plane film, is calculated by mass percentage, contains following components：
3.5 parts of hyaluronic acid and epidermal growth factor key compound, 5 parts of gallic acid, 12 parts of emulsifier, 4 parts of evening primrose oil,
5 parts of vitamin E, 5 parts of Bergamot, 4 parts of glycerine, surplus is water.The facial mask has anti-acne repair function.
Wherein, the preparation process of hyaluronic acid and epidermal growth factor key compound is：
The hyaluronic acid that 4g molecular weight is 10,000 is dissolved in 100ml PBS buffer solutions (4%, w/v), adjusting pH is
7.5,400mg sodium metaperiodate open loops are added, the epidermal growth factor of 200mg, conjugation condensation reaction 8 hours, it is ensured that reaction is added
Completely；After purification, freeze-drying, nuclear magnetic resonance confirms gel chromatography.
Embodiment 6
A kind of hyaluronic acid peptide bond object plane film, is calculated by mass percentage, contains following components：
3 parts of hyaluronic acid and palmitic acid SymPeptide key compound, 4 parts of kojic acid, 8 parts of emulsifier dissolve 1~4 part of keratinase,
3 parts of niacinamide, 2 parts of lemon, 2 parts of glycerine, surplus is water.A kind of facial mask anti-wrinkle face mask in fact.
Wherein, the preparation process of hyaluronic acid and palmitic acid SymPeptide key compound is：
The hyaluronic acid that 5.0g molecular weight is 25,000 is dissolved in 85ml PBS buffer solutions (5.88%, w/v), is adjusted
PH is 7.5, and 200mg sodium metaperiodate open loops are added, and the palmitic acid SymPeptide key compound of 175mg is added, and conjugation condensation reaction 8 is small
When, it is ensured that the reaction was complete；After purification, freeze-drying, nuclear magnetic resonance confirms gel chromatography.Hyaluronic acid and palmitic acid SymPeptide key compound
Nuclear magnetic spectrogram it is as shown in Figure 2.
Embodiment 7
A kind of hyaluronic acid peptide bond object plane film, is calculated by mass percentage, contains following components：
1.0 parts of hyaluronic acid and acetyl group hexapeptide key compound, 2.5 parts of vitamin B3,9 parts of dissolving keratinases 3 of emulsifier
Part, 4 parts of D~pantothenic acid, 2 parts of Peppermint essential oil, 4 parts of glycerine, surplus is water.
Embodiment 8
A kind of hyaluronic acid peptide bond object plane film, is calculated by mass percentage, contains following components：
Hyaluronic acid and more 5.0 parts of palmityl tetrapeptide key compounds, 2.5 parts of vitamin C, 10 parts of emulsifier, keratolytic
2 parts, 4 parts of vitamin E, 2 parts of Rosa Damascana, 2 parts of glycerine, surplus is water.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
With technical scheme described in the above embodiments is modified or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in the present invention's
Within protection domain.
Claims (7)
1. a kind of hyaluronic acid peptide bond object plane film, which is characterized in that be calculated by mass percentage, contain following components：
0.1~20 part of hyaluronic acid peptide bond object, 0.1~10.0 part of skin whitening agent, 2.0~20.0 parts of emulsifier, cutin
0.5~20.0 part of softening agent, 1.0~15.0 parts of external skin wrinkling-preventing agent, 0.1~5.0 part of aromatic, 0.1~10.0 part of glycerine, surplus
For water；The hyaluronic acid peptide bond object refers to hyaluronic acid and fibroblast growth factor, epidermal growth factor, blood vessel
One or more of endothelial growth factors, superoxide dismutase, palmityl tetrapeptide, palmitic acid SymPeptide, acetyl group hexapeptide
Conjugation is bonded and obtains, and the hyaluronan molecule amount is less than 50KDa；The preparation method of the hyaluronic acid peptide bond object
For the hyaluronic acid that 1~5g molecular weight is 10,000~30,000 is dissolved in 80~100ml PBS buffer solutions, pH is adjusted
It is 7.0~8.0, the polypeptide of the open loop of 100~400mg sodium metaperiodates and 100~200mg is added, is conjugated condensation reaction 8 hours, really
The reaction was complete by guarantor；After purification, freeze-drying, nuclear magnetic resonance confirms gel chromatography.
2. a kind of hyaluronic acid peptide bond object plane film as described in claim 1, which is characterized in that by mass percentage
It calculates, contains following components：
1.0~5.0 parts of hyaluronic acid peptide bond object, 2.5~5 parts of skin whitening agent, 8~12 parts of emulsifier, keratolytic 1
~4 parts, 3~5 parts of external skin wrinkling-preventing agent, 0.1~5 part of aromatic, 2~4 parts of glycerine, surplus is water.
3. a kind of hyaluronic acid peptide bond object plane film as claimed in claim 1 or 2, which is characterized in that the skin is beautiful
White agent is any one or a few in vitamin C, Seabuckthorn Oil, tartaric acid, ascorbic acid, gallic acid, kojic acid, vitamin B3.
4. a kind of hyaluronic acid peptide bond object plane film as claimed in claim 1 or 2, which is characterized in that the cutin is soft
Agent lanolin, sunflower oil, grape seed oil, safflower oil, evening primrose oil, dissolving keratinase in any one or a few.
5. a kind of hyaluronic acid peptide bond object plane film as claimed in claim 1 or 2, which is characterized in that the skin is anti-
Wrinkle agent is any one or a few in niacin, niacinamide, D~pantothenic acid, vitamin E.
6. a kind of hyaluronic acid peptide bond object plane film as claimed in claim 1 or 2, which is characterized in that the aromatic
For appointing in salvia officianlis oil, Rosa Damascana, chamomile essential oil, Lavender, Bergamot, lemon, Peppermint essential oil
Meaning is one or more of.
7. a kind of preparation method of hyaluronic acid peptide bond object plane film, which is characterized in that include the following steps：
0.1~20 part of hyaluronic acid peptide bond object, 0.1~10.0 part of skin whitening agent, 2.0~20.0 parts of emulsifier, cutin
0.5~20.0 part of softening agent is added in ultra-pure water, is stirred evenly at 40~50 DEG C, spare；
(2) 1.0~15 parts of external skin wrinkling-preventing agent, 0.1~5 part of aromatic, 0.1~10 part of glycerine are uniformly mixed, spare；
(3) mixture obtained by step (1) is cooled to 35 DEG C, is added in the mixture that step (2) obtains, stirs evenly；
(4) ultra-pure water is added in the mixture obtained to step (3), until mixture gross mass is 100 parts.
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| CN201410591484.1A CN105616184B (en) | 2014-10-28 | 2014-10-28 | A kind of hyaluronic acid peptide bond object plane film and preparation method thereof |
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| CN201410591484.1A CN105616184B (en) | 2014-10-28 | 2014-10-28 | A kind of hyaluronic acid peptide bond object plane film and preparation method thereof |
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| CN105616184A CN105616184A (en) | 2016-06-01 |
| CN105616184B true CN105616184B (en) | 2018-08-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2810057C2 (en) * | 2018-12-19 | 2023-12-21 | Мерц Фарма Гмбх Энд Ко. Кгаа | Aldehyde modified hyaluronic acid, method of its preparation and its use |
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| CN107185031B (en) * | 2017-05-23 | 2019-03-26 | 广州润虹医药科技股份有限公司 | A kind of biologically active medical dressing and preparation method thereof |
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