CN105616164A - Multi-layer dripping pill device, component thereof and preparation process of multi-layer pill dripping device - Google Patents
Multi-layer dripping pill device, component thereof and preparation process of multi-layer pill dripping device Download PDFInfo
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- CN105616164A CN105616164A CN201610187580.9A CN201610187580A CN105616164A CN 105616164 A CN105616164 A CN 105616164A CN 201610187580 A CN201610187580 A CN 201610187580A CN 105616164 A CN105616164 A CN 105616164A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/40—Heating or cooling means; Combinations thereof
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Abstract
The invention relates to a multi-layer dripping pill device, a component thereof and a preparation process of the multi-layer dripping pill device. On one hand, the dripping head for preparing the multi-layer dripping pill is of a combined structure capable of being detached and assembled and comprises an inner layer material guide-in piece, a middle material guide-in piece, an outer layer material guide-in piece and a connecting part, the whole dripping head is in a barrel shape, and a first connector, a second connector and a third connector are sequentially arranged in the dripping head from top to bottom and used for being connected with the inner layer material guide-in piece, the middle material guide-in layer and the outer layer material guide-in piece respectively so that the three material guide-in pieces can be connected into a coaxial whole in the connecting part. The invention further relates to the multi-layer dripping pill device with the dripping head, the dripping head of the multi-layer dripping pill device, and a method for preparing multi-layer dripping pills through the multi-layer dripping pill device. The multi-layer dripping pill device and the component of the multi-layer dripping pill device have various excellent properties as mentioned in the specification.
Description
Technical field
The present invention relates to technical field of mechanical equipment, particularly relate to pharmaceutical machine apparatus field, more particularly relate to a kind of equipment and the key part thereof of preparing multilayer pill, more particularly relate to a kind of equipment and the key part thereof that can prepare three layers of pill, and the three of these three layers of pills layers can be the material of different properties feature.
Background technology
Pill is a kind of high-end formulation of art of pharmacy, can give medicament with property due to its special construction.
Pill be solid or liquid medicine and suitable material (being commonly referred to as matrix) heat fused mix even after, the pellets preparation drip in not miscible phlegma, shrinking condensation and make, main for orally using.
From the composition of pill, method for making, it has the following feature: 1, equipment simple, easy to operate, be beneficial to labour protection, process cycle is short, productivity height; 2, processing condition are easy to control, steady quality, and dosage is accurate, and heated time is short, and the volatile medicine of oxidizable and tool can increase its stability after being dissolved in matrix; 3, matrix holds liquid drug amount greatly, therefore liquid drug can be made to solidify, and can reach 83.5% as rue oil drips ball oil-containing; 4, with solid dispersion technology prepare drip ball have absorb rapidly, feature that bioavailability is high, be the 1/4 of 100 order fine powders as grisovin drips ball effective dose, the 1/2 of micro-powder (particle diameter less than 5 microns); 5, having developed ear, ophthalmic remedy novel form, department of eye preparation mostly is liquid or semi-solid state formulation, and action time is lasting, is made and drips a ball and can play and prolong effect effect.
Pill has the advantage of " three effects ", and three effects refer to quick-acting, efficient, long-acting. Drip ball mostly be sublingual administration, medicine is directly absorbed by sublingual mucosa, enters blood circulation, avoids the liver first-pass effect caused when swallowing, and medicine in stomach degraded loss, make high drug concentration arrive target organ, rapid-onset. Generally containing taking 5 15 minutes with regard to energy onset, it is no more than at most 30 minutes. What have also adds sustained release dosage, can transformation period of obvious prolong drug, reach long-acting object. When needing, suck.
Current pill mainly contains following kind:
Quick-acting efficient pill: dripping ball is utilize the technology of solid dispersion to be prepared. When stromatolysis, drug disposition disengages with fine crystalline, amorphous fine-particle or molecular form, thus dissolve fast, absorb fast, effect is fast, bioavailability height. The representative instance of this series products is quick-acting cardiac pain pill.
Sustained-release and controlled release drips ball: slow releasing is the medicine slowly stripping in a long time making to drip in ball, and reaches long-acting; It is that medicine is being dripped with constant speed stripping in ball that control is released, and its effect can reach a few days more than, such as chloromycetin controlled release eye-pill.
Solution drips ball: tablet lubricant used, disintegrating agent mostly are water-insoluble, so being generally not capable of configuring clear and bright solution with tablet. And drip a ball used water soluble base and configure, can disintegration be clear and bright solution in water, drip ball than Thailand can be used for disinfection of drinking water as washed.
Suppository drips ball: drip ball with the Water-miscible suppository equally water-soluble base such as available polyoxyethylene glycol, for dissolving generation effect by body fluid during cavity. Such as Norxin Ear drop pill, metronidazole dental dropping pill etc. Dripping ball can equally for rectum, it is possible to directly acts on whole body by rectal absorption, has bioavailability height, act on fast feature.
Hard capsule drips ball: what can load different dissolution rate in hard capsule drips ball, and to form the slow-release pill capsule of required dissolution rate, the hard capsule such as Biphenylylmethylcarbinol drips ball.
Coated drop pill: same to tablet, pill equally need bag sugar-coat, film-coat etc., such as bifendate drop pill.
Elaioplast drop ball: liposome is suspension body, can be made into solid dosage with polyoxyethylene glycol adds liposome under constantly stirring in the Macrogol 4000 of melting to form suspension, and it is shaping to be poured in model condensation.
Enteric coating drips ball: be used in stomach undissolved matrix, is with gelatin solution after matrix becomes ball as food and drink acid antimony potassium drips ball, by formaldehyde treated, the amino of gelatin is not dissolved in gastric juice, dissolve in intestines.
Dry-pressing coated drop pill: to drip centered by ball, press the clothing layer of other drug composition, merged the advantage of two kinds of formulations, such as the pentoxiverin Repone K dry coated tablet of kobadrin. The former is for dripping ball, and the latter is clothing layer.
But, in some cases, Cucumber needs when making pill to partially absorb at special digestive tube, such as, need in little intestinal absorption, and can not contact with in acid gastric juice in stomach. It is even that dropping pill technique can realize producing composition, the pill of high roundness, and drug release can be made even, and time of releasing is long, is convenient to carry and preserve. Dropping pill technique major part domestic at present is single component preparation, can not wrapped up by the material of effective constituent provide protection, it is achieved the object of multiple coatings, and therefore, it is a kind of typical scenario addressed this problem that preparation multilayer drips ball. Particularly,
If multilayer pill equipment and technique thereof are studied successfully, the effective constituent complete parcel of material of anti-hydrochloric acid in gastric juice can be protected, through small intestine even large intestine discharge again, it is achieved maximumization of effect. Such as, the through large intestine of probiotic bacterium. For improving intestinal function, promote that intestinal microflora balance has significant effect. Also can utilize this technological development new medicinal preparation, the medicine being afraid of acid be avoided hydrochloric acid in gastric juice and sends into large intestine, for absorption of human body, it is to increase the result for the treatment of of medicine. Or exploitation multilayer slow releasing pharmaceutical allows the medicine of every layer play effectiveness etc. successively, for medicine or the food of new preparation provides pratical and feasible approach.
A ball for classics is not stratified, drips the mixture that ball is equal from the inside to surface, and along with the needs of preparation development, the exploitation that multilayer drips ball (such as a double-deck ball or three layers balls) presents powerful demand. These multilayers drip the soft capsule that the ball such as double-deck preparation technology dripping ball is different from dropping method and produces because their content is liquid, and multilayer drip ball such as the double-deck internal composition dripping ball at normal temperatures substantially in solid. Therefore, soft capsule production unit/technique cannot be applied to multilayer drip ball (such as double-deck drip ball or three layers drip balls).
Therefore, it is provided that a kind of can dripping become multilayer particularly three layers drip the equipment of balls and/or its parts, and this kind of equipment can provide excellent production efficiency, is still what those skilled in the art urgently expected.
Summary of the invention
It is an object of the invention to provide a kind of can dripping become multilayer particularly three layers drip the equipment of balls and/or its parts, particularly its water dropper parts, these parts are also the core components that preparation multilayer drips ball. Have been surprisingly found that three layers with present configuration feature equipment and/or its parts dripping ball, it is possible to obtain unexpected technique effect. Therefore the present invention is accomplished.
In a first aspect of the present invention, the present invention provides a kind of water dropper for the preparation of multilayer pill, and it is the integrated structure can dismantled and assemble, comprising:
I) internal layer material imports part, it is generally in nail-like, the upper end bulb that the internal layer material of this nail-like imports part is provided with the first interface for being connected with interconnecting piece, the internal layer material of this nail-like imports part and arranges a through internal layer through hole from the top to the bottom, and this internal layer through hole flows to bottom from the upper end that this internal layer material imports part for making internal layer material and flows out;
Ii) intermediate material imports part, it is generally in nail-like, the upper end bulb that the intermediate material of this nail-like imports part is provided with the 2nd interface for being connected with interconnecting piece, and the intermediate material of this nail-like imports part and arranges a through intermediate throughholes from the top to the bottom; The external diameter that internal layer material described in the aperture ratio of this intermediate throughholes imports the lower end needle like section of part is thick, and the lower end needle like section that described internal layer material imports part can insert in this intermediate throughholes;
Iii) outer skin materials imports part, and it is generally in inverted hollow circular cone shape, and the upper end bulb that the outer skin materials of this circular cone shape imports part is provided with the 3rd interface for being connected with interconnecting piece; The hollow parts that the outer skin materials of this circular cone shape imports part inside is thicker than the external diameter of the lower end needle like section of described intermediate material importing part, and the lower end needle like section that described intermediate material imports part can insert in the hollow parts that this outer skin materials imports part inside;
Iv) interconnecting piece, it is generally in barrel-shaped, its inside is disposed with the first interface, the 2nd interface and the 3rd interface from top to bottom, to be respectively used to importing part with internal layer material, intermediate material imports part and outer skin materials importing part three is connected so that described three kinds of materials import part and connect into coaxial unitary form in this interconnecting piece inside.
Dripping in ball production, it is extremely important that water dropper can easily carry out dismantling and assembling, and these work are very big for the time cost impact produced, because the cleaning dripping ball material in many cases is wasted time and energy very much. Applicant not yet find prior art have than the present invention be more convenient for dismounting and assembling multilayer drip ball water dropper design.
The water dropper for the preparation of multilayer pill according to the present invention, wherein said first interface, the 2nd interface and the 3rd interface are in being selected from following structure independently of one another: helicitic texture, patch structure. As long as the structure of these interfaces can reach the requirement of sealing usually.
The water dropper for the preparation of multilayer pill according to the present invention, wherein after described internal layer material imports part, intermediate material importing part, outer skin materials importing part and interconnecting piece assembling, there is a gap between the upper edge of the upper end bulb of the lower edge of the upper end bulb of the internal layer material importing part of described nail-like and the intermediate material importing part of described nail-like, this gap is called the first gap.
The water dropper for the preparation of multilayer pill according to the present invention, described first gap location is just being provided with one or more hole imported for intermediate material by the wherein said wall in barrel-shaped interconnecting piece, this/this some holes is called that intermediate material imports hole. Thus, intermediate material imports hole by the intermediate material of interconnecting piece, enters in the first gap, then the gap slightly formed via the external diameter of the lower end needle like section of the aperture ratio internal layer material importing part of described intermediate throughholes flows to the outlet of water dropper downwards.
The water dropper for the preparation of multilayer pill according to the present invention, wherein after described internal layer material imports part, intermediate material importing part, outer skin materials importing part and interconnecting piece assembling, there is a gap between the upper edge of the upper end bulb of the lower edge of the upper end bulb of the intermediate material importing part of described nail-like and the outer skin materials importing part of described circular cone shape, this gap is called the 2nd gap.
The water dropper for the preparation of multilayer pill according to the present invention, described 2nd gap location is just being provided with one or more hole imported for outer skin materials by the wherein said wall in barrel-shaped interconnecting piece, this/this some holes is called that outer skin materials imports hole. Thus, outer skin materials imports hole by the outer skin materials of interconnecting piece, enter in the 2nd gap, then flow to the outlet of water dropper via the described outer skin materials inner hollow parts of importing part than the gap that the external diameter of the lower end needle like section of intermediate material importing part is slightly formed downwards.
The water dropper for the preparation of multilayer pill according to the present invention, the lower edge that wherein said internal layer material imports part, intermediate material importing part imports part three with outer skin materials is concordant. Thus, when bringing out mouth outflow under this internal layer through hole from the internal layer material of the internal layer through hole outflow of internal layer material importing part inside, it is wrapped to form double-deck piller by the intermediate material flowed out via the first gap; And this bilayer piller is wrapped to form three layers of piller by the outer skin materials flowed out via the 2nd gap then.
The water dropper for the preparation of multilayer pill according to the present invention, the upper end of wherein said internal layer through hole is connected with internal layer material supplying device, to provide uninterrupted internal layer material.
The water dropper for the preparation of multilayer pill according to the present invention, wherein one or more described intermediate material imports hole and is connected with intermediate material supply device, to provide uninterrupted intermediate material.
The water dropper for the preparation of multilayer pill according to the present invention, wherein one or more described outer skin materials imports hole and is connected with outer skin materials supply device, to provide uninterrupted outer skin materials.
The water dropper for the preparation of multilayer pill according to the present invention, it comprises an intermediate material and imports part, and drips ball for the preparation of three layers.
The water dropper for the preparation of multilayer pill according to the present invention, it comprises two intermediate materials and imports part, and drips ball for the preparation of four layers. Preferential, it is substantially identical that described two intermediate materials import part shape, and just thickness length is different; Wherein elongated intermediate material imports part and is connected with described internal layer material importing part, slightly short intermediate material imports part and is connected with outer skin materials importing part, and the intermediate material that elongated intermediate material imports the insertion of part lower end needle like section slightly short imports in the intermediate throughholes in part. Similarly, when comprising three intermediate materials and import part and arrange with above-mentioned similar fashion, it is possible to drip ball for the preparation of five layers.
The water dropper for the preparation of multilayer pill according to the present invention, it comprises 1��4 intermediate material and imports part. Preferential, it comprises 1��3 intermediate material and imports part. Preferential, it comprises 1��2 intermediate material and imports part. Preferential, it comprises 1 intermediate material and imports part.
The water dropper for the preparation of multilayer pill according to the present invention, described first gap location is just being provided with 1��3 intermediate material importing hole by the wherein said wall in barrel-shaped interconnecting piece. preferably being provided with 2 intermediate materials and import hole, one of them hole is for importing intermediate material, and another hole is for subsequent use, can block with stifled head in the not used time, or 2 intermediate materials import Kong Jun for importing intermediate material, or, a hole is for importing intermediate material (its front end is provided with force (forcing) pump to make intermediate material flow to water dropper direction in the way of having pressure), another hole is for deriving intermediate material (its rear end no pressure, and it can derive unnecessary material or the pressure for intermediate material in regulating dropping head) and the material now derived is back to intermediate material pond by loop. have been surprisingly found that, when described first gap location is just being provided with 2 intermediate materials importing holes by the described wall in barrel-shaped interconnecting piece, and hole for import intermediate material and another hole for deriving intermediate material time, higher than only there being the design in an intermediate material importing hole, (drip ball roundness is drip the ratio of the shortest footpath of ball with the longest footpath to the ball roundness of dripping obtained so significantly, arranging a ball roundness average when an intermediate material imports hole is in 0.89��0.92 scope, and when arranging one as mentioned above and enter 2 intermediate materials importing holes that goes out, dripping ball roundness is (two numerical ranges are 6 kinds of different material trial values) in 0.96��0.99 scope, these numerical value are all import Kong Yiru above-mentioned at outer skin materials to enter 2 intermediate materials out and import the water dropper that hole modes arrange and obtain).
The water dropper for the preparation of multilayer pill according to the present invention, described 2nd gap location is just being provided with 1��3 outer skin materials importing hole by the wherein said wall in barrel-shaped interconnecting piece. preferably being provided with 2 outer skin materials and import hole, one of them hole is for importing outer skin materials, and another hole is for subsequent use, can block with stifled head in the not used time, or 2 outer skin materials import Kong Jun for importing outer skin materials, or, a hole is for importing outer skin materials (its front end is provided with force (forcing) pump to make outer skin materials flow to water dropper direction in the way of having pressure), another hole is for deriving outer skin materials (its rear end no pressure, and it can derive unnecessary material or the pressure for outer skin materials in regulating dropping head) and the material now derived is back to outer skin materials pond by loop. have been surprisingly found that, when described 2nd gap location is just being provided with 2 outer skin materials importing holes by the described wall in barrel-shaped interconnecting piece, and hole for import outer skin materials and another hole for deriving outer skin materials time, higher than only there being the design in an outer skin materials importing hole, (arrange a ball roundness average when an outer skin materials imports hole is in 0.88��0.92 scope to the ball roundness of dripping obtained so significantly, and when arranging one as mentioned above and enter 2 outer skin materials importing holes that goes out, dripping ball roundness is (two numerical ranges are 6 kinds of different material trial values) in 0.97��0.99 scope, these numerical value are all import Kong Yiru above-mentioned at intermediate material to enter 2 outer skin materials out and import the water dropper that hole modes arrange and obtain).
The water dropper for the preparation of multilayer pill according to the present invention, it is the water dropper dripping ball for the preparation of three layers. Now intermediate material imports part only.
The water dropper for the preparation of multilayer pill according to the present invention, its internal layer material imports part, intermediate material imports part and outer skin materials importing part three reduces a formation droplet mouth gradually at bottom bore.
The water dropper for the preparation of multilayer pill according to the present invention, along in three concentric(al) circless seen mouth when looking up from its underpart, import part bottom by internal layer material successively from the inside to the outside, intermediate material imports part bottom, outer skin materials imports part bottom three and forms, innermost layer is used for the outflow of internal layer material, middle layer is used for the outflow of intermediate material, and outermost layer is used for the outflow of outer skin materials.
The water dropper for the preparation of multilayer pill according to the present invention, along in three concentric(al) circless, forming innermost layer region, interlayer region, outermost region seen water dropper when looking up from its underpart. when using 6 kinds of different materials to test, have been found that, innermost layer region area: interlayer region area: when selecting in the big mobility scale of outermost region area=1:0.5��5:0.8��10, all can prepare the ball (adopting intermediate material to import hole and outer skin materials importing hole all to adopt as above-mentioned enters a test-results outing the design in 2 holes and obtaining) to drip ball roundness and being greater than 0.96, regrettable is, adopt three layers of design (Fig. 4 of such as CN100506093C-200480028272.1 of some documents, Fig. 1 of CN201750916U-201020224428.1, Fig. 3 of CN104219951A-201280067210.1) test same material, adjust innermost layer region area in these literature protocol: interlayer region area: when outermost region area is also selected in the big mobility scale of 1:0.5��5:0.8��10, gained drips ball roundness all in 0.67��0.86 scope, their dripping successful ground is not as good as the present invention program.
The water dropper for the preparation of multilayer pill according to the present invention, along in three concentric(al) circless seen water dropper when looking up from its underpart, form innermost layer region, interlayer region, outermost region, the area ratio of this three and innermost layer region area: interlayer region area: outermost region area=1:0.5��5:0.8��10.
The water dropper for the preparation of multilayer pill of the present invention, it can be used in conventional multilayer drilling pill device, such as, as said in CN100506093C-200480028272.1, CN201750916U-201020224428.1, CN104219951A-201280067210.1. In an example, the water dropper of the present invention is used for multilayer pill equipment. These multilayer pill equipment generally include the temperature controlling system of the material suppling system, control material and the water dropper temperature that are connected with water dropper.
For this reason, second aspect present invention provides a kind of multilayer pill equipment, comprising:
Water dropper (particularly the water dropper of such as first aspect present invention);
The material supply pipeline being connected with described water dropper;
Material supply is filled with;
For material supply filling, material supply pipeline and water dropper provide temperature controlled temperature controlling system; With
Drip ball receiving trap.
Filling with a set of material supply pipeline and material supply due to one layer of water dropper and is connected, therefore a set of temperature controlling system can control a set of water dropper, material supply pipeline and material supply filling. Certainly, it is also possible to adopt a set of temperature controlling system to fill with control many covers water dropper, material supply pipeline and material supply.
Multilayer pill equipment according to a second aspect of the present invention, wherein said a set of temperature controlling system controls a set of water dropper, material supply pipeline and material supply individually and fills with. Like this, it is possible to easily realize the material to different layers and carry out the temperature control of independent ground.
Multilayer pill equipment according to a second aspect of the present invention, wherein said temperature controlling system is circulating air Controlling System.
Multilayer pill equipment according to a second aspect of the present invention, wherein said ball receiving trap comprises a ball cooling end and drips a ball recovery portion. Described ball cooling end adopts whiteruss etc. usually. This also well known to a person skilled in the art.
Further, third aspect present invention provides the method preparing multilayer pill (such as three layers of pill), and it comprises the steps:
1) material of each layer of ball is dripped in preparation respectively;
2) being added to by each layer material in the filling of corresponding material supply respectively, the material inlet that the filling of each material supply imports part to the material of the corresponding layer of water dropper (particularly the water dropper of such as first aspect present invention) respectively connects;
3) start-up temperature Controlling System, makes the temperature of the material in material supply filling, material supply pipeline and water dropper control in the prescribed value or scope of this material;
4) after each layer temperature of charge balances, open and drip ball dripping program, the ball that drips dripping is dripped in ball receiving trap.
State in the step of preparation method on the invention, although its describe concrete steps in some details or language describe up and down literary composition embodiment part the step described in preparation example distinguish to some extent, but, those skilled in the art can summarize the above method steps completely according to the open in detail of the present invention's full text.
Any embodiment of the either side of the present invention, it is possible to combine with other embodiment, as long as they there will not be contradiction. In addition, in any embodiment of either side of the present invention, any technology feature goes for this technology feature in other embodiment, as long as they there will not be contradiction.
The invention will be further described below.
All documents that the present invention quotes from, their whole contents are incorporated to herein by reference, and if when the implication expressed by these documents and the present invention are inconsistent, being as the criterion with the statement of the present invention. In addition, the various term that the present invention uses and phrase have and well known to a person skilled in the art general implication, nonetheless, the present invention still wishes at this, these terms and phrase to be described in more detail and explained, if any with public affairs, the term mentioned and phrase know that implication is inconsistent, be as the criterion with the implication that the present invention states.
The equipment and process of the present invention provides that one is more advanced and more reliable medicine technique for packing, compares capsule and fills, and packaging technique, multilayer drips ball better tightness, wraps up reliable more comprehensively. After believing industrialization, economic and social benefit will be very remarkable. The investigator of the present invention is devoted to study principle and its implementation of multilayer dropping pill technique; This investigator has manufactured and designed the three layers of drilling pill device that can be used for industrialization.
The multilayer pill equipment of the present invention and technique thereof, this technology can the not congruent medicine of industrialization production spherical shape multilayer or food formulation, it is possible to dripping becomes two layers, three layers, four layers until the number of plies that needs as requested. Three layers of schematic illustration dripping balls are shown in Fig. 1, its mesectoderm and middle layer ratio thicker in existing conventional soft capsule thin skin skin, and as described herein, prior art processes equipment is cannot a ball of the such thickness of dripping.
Accompanying drawing explanation
Fig. 1 is three layers of schematic isometric model diagram dripping ball.
Fig. 2 is the diagrammatic cross-section of the present invention's (three layers) water dropper.
The bottom bore that Fig. 3 is the present invention's (three layers) water dropper reduces a formation droplet mouth gradually, seen mouth schematic diagram when looking up from this water dropper bottom, from figure, along in three concentric(al) circless under this mouth, import part bottom by internal layer material successively from the inside to the outside, intermediate material imports part bottom, outer skin materials imports part bottom three and forms, innermost layer is used for the outflow of internal layer material, and middle layer is used for the outflow of intermediate material, and outermost layer is used for the outflow of outer skin materials.
Fig. 4 is preparation technology's schematic diagram of multilayer pill equipment of the present invention and parts and multilayer pill, illustrate only the flow process of a set of material in figure, and does not illustrate cooling system.
Embodiment
The present invention can be conducted further description by the following examples, but, the scope of the present invention is not limited to following embodiment. One of skill in the art is it can be appreciated that under the prerequisite not deviating from the spirit and scope of the present invention, it is possible to the present invention carries out various change and modification. The material used in test and test method are carried out generality and/or concrete description by the present invention. Although being well known in the art for realizing many materials that the object of the invention uses and working method, but the present invention still describes as far as possible in detail at this work. Following examples illustrate the present invention further, instead of restriction the present invention.
The ball shown in Fig. 1 schematic isometric model diagram can be obtained by multilayer of the present invention (three layers) water dropper.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, schematically as shown in Figure 2, this water dropper is the integrated structure can dismantled and assemble, comprising:
I) internal layer material imports part 1, it is generally in nail-like, the upper end bulb 12 that the internal layer material of this nail-like imports part 1 is provided with the first interface 14 for being connected with interconnecting piece 4, the internal layer material of this nail-like imports part 1 and arranges a through internal layer through hole 11 from the top to the bottom, and this internal layer through hole 11 flows to bottom from the upper end that this internal layer material imports part 1 for making internal layer material and flows out;
Ii) intermediate material imports part 2, it is generally in nail-like, the upper end bulb 22 that the intermediate material of this nail-like imports part 2 is provided with the 2nd interface 24 for being connected with interconnecting piece 4, and the intermediate material of this nail-like imports part 2 and arranges a through intermediate throughholes 21 from the top to the bottom; The external diameter that internal layer material described in the aperture ratio of this intermediate throughholes 21 imports the lower end needle like section of part 1 is thick, and the lower end needle like section that described internal layer material imports part 1 can insert in this intermediate throughholes 21;
Iii) outer skin materials imports part 3, and it is generally in inverted hollow circular cone shape, and the upper end bulb 32 that the outer skin materials of this circular cone shape imports part 3 is provided with the 3rd interface 34 for being connected with interconnecting piece 4; The hollow parts 31 that the outer skin materials of this circular cone shape imports part 3 inside is thicker than the external diameter of the lower end needle like section of described intermediate material importing part 2, and the lower end needle like section that described intermediate material imports part 2 can insert in the hollow parts 31 that this outer skin materials imports part 3 inside;
Iv) interconnecting piece 4, it is generally in barrel-shaped, its inside is disposed with the first interface 14, the 2nd interface 24 and the 3rd interface 34 from top to bottom, to be respectively used to importing part 1 with internal layer material, intermediate material imports part 2 and outer skin materials importing part 3 three is connected so that described three kinds of materials import part and connect into coaxial unitary form in this interconnecting piece 4 inside.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, wherein said first interface 14, the 2nd interface 24 and the 3rd interface 34 are in being selected from following structure independently of one another: helicitic texture, patch structure. As long as the structure of these interfaces can reach the requirement of sealing usually. Helicitic texture is preferential because its be easier to sealing and wearing quality is good.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, wherein after described internal layer material imports part 1, intermediate material importing part 2, outer skin materials importing part 3 and interconnecting piece 4 four assembling, there is a gap between the upper edge of the upper end bulb 22 of the lower edge of the upper end bulb 12 of the internal layer material importing part 1 of described nail-like and the intermediate material importing part 2 of described nail-like, this gap is called the first gap 13.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, described first gap 13 place is just being provided with one or more hole imported for intermediate material by the wherein said wall in barrel-shaped interconnecting piece 4, this/this some holes is called that intermediate material imports hole 41. Thus, intermediate material imports hole 41 by the intermediate material of interconnecting piece 4, enters in the first gap 13, then the gap slightly formed via the external diameter of the lower end needle like section of the aperture ratio internal layer material importing part 1 of described intermediate throughholes 21 flows to the outlet of water dropper downwards. Fig. 2 having illustrated, two intermediate materials import hole 41.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, wherein after described internal layer material imports part 1, intermediate material importing part 2, outer skin materials importing part 3 and interconnecting piece 4 four assembling, there is a gap between the upper edge of the upper end bulb 32 of the lower edge of the upper end bulb 22 of the intermediate material importing part 2 of described nail-like and the outer skin materials importing part 3 of described circular cone shape, this gap is called the 2nd gap 23.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, described 2nd gap 23 place is just being provided with one or more hole imported for outer skin materials by the wherein said wall in barrel-shaped interconnecting piece 4, this/this some holes is called that outer skin materials imports hole 42. Thus, outer skin materials imports hole 42 by the outer skin materials of interconnecting piece 4, enter in the 2nd gap 23, then flow to the outlet of water dropper via the described outer skin materials inner hollow parts 31 of importing part 3 than the gap that the external diameter of the lower end needle like section of intermediate material importing part 2 is slightly formed downwards. Fig. 2 having illustrated, two outer skin materials import hole 42.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, wherein said internal layer material imports part 1, to import the lower edge that part 2 imports part 3 three with outer skin materials be concordant to intermediate material. Thus, from the internal layer material of internal layer through hole 11 outflow of internal layer material importing part 1 inside when this internal layer through hole brings out mouth outflow for 11, it is wrapped to form double-deck piller by the intermediate material flowed out via the first gap 13; And this bilayer piller is wrapped to form three layers of piller by the outer skin materials flowed out via the 2nd gap 23 then.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, the upper end of wherein said internal layer through hole 11 is connected with internal layer material supplying device, to provide uninterrupted internal layer material.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, the described intermediate material of wherein one or more imports hole 41 and is connected with intermediate material supply device, to provide uninterrupted intermediate material.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, the described outer skin materials of wherein one or more imports hole 42 and is connected with outer skin materials supply device, to provide uninterrupted outer skin materials.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, it comprises an intermediate material and imports part 2, and drips balls for the preparation of three layers. The exemplary water dropper of Fig. 2 is exactly the design dripping balls for the preparation of three layers.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, it comprises two intermediate materials and imports parts 2, and drips balls for the preparation of four layers. Preferential, it is substantially identical that described two intermediate materials import part 2 shape, and just thickness length is different; Wherein elongated intermediate material imports part 2 and is connected with described internal layer material importing part 1, slightly short intermediate material imports part 2 and is connected with outer skin materials importing part 3, and the intermediate material that elongated intermediate material imports part 2 times end needle like section insertions slightly short imports in the intermediate throughholes 21 in part 2. Similarly, when comprising three intermediate materials and import part 2 and arrange with above-mentioned similar fashion, it is possible to drip ball for the preparation of five layers.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, it comprises 1��4 intermediate material and imports part 2. Preferential, it comprises 1��3 intermediate material and imports part 2. Preferential, it comprises 1��2 intermediate material and imports part 2. Preferential, it comprises 1 intermediate material and imports part 2. The exemplary water dropper of Fig. 2 is exactly the design dripping balls for the preparation of three layers, it may also be useful to 1 intermediate material imports part 2.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, the wherein said wall in barrel-shaped interconnecting piece 4 imports hole 41 described first gap 13 place is just being provided with 1��3 intermediate material. preferably being provided with 2 intermediate materials and import hole 41, one of them hole is for importing intermediate material, and another hole is for subsequent use, can block with stifled head in the not used time, or 2 intermediate materials import hole 41 all for importing intermediate material, or, a hole is for importing intermediate material (its front end is provided with force (forcing) pump to make intermediate material flow to water dropper direction in the way of having pressure), another hole is for deriving intermediate material (its rear end no pressure, and it can derive unnecessary material or the pressure for intermediate material in regulating dropping head) and the material now derived is back to intermediate material pond by loop. have been surprisingly found that, when described first gap 13 place is just being provided with 2 intermediate materials importing holes 41 by the described wall in barrel-shaped interconnecting piece 4, and hole for import intermediate material and another hole for deriving intermediate material time, higher than only there being the design in an intermediate material importing hole 41, (drip ball roundness is drip the ratio of the shortest footpath of ball with the longest footpath to the ball roundness of dripping obtained so significantly, arranging a ball roundness average when an intermediate material imports hole is in 0.89��0.92 scope, and when arranging one as mentioned above and enter 2 intermediate materials importing holes that goes out, dripping ball roundness is (two numerical ranges are 6 kinds of different material trial values) in 0.96��0.99 scope, these numerical value are all import hole 42 at outer skin materials also to enter 2 intermediate materials out such as above-mentioned one and import the water dropper that hole 41 modes arrange and obtain).
According to the example of the present invention for the preparation of the water dropper of multilayer pill, the wherein said wall in barrel-shaped interconnecting piece 4 imports hole 42 described 2nd gap 23 place is just being provided with 1��3 outer skin materials. preferably being provided with 2 outer skin materials and import hole 42, one of them hole is for importing outer skin materials, and another hole is for subsequent use, can block with stifled head in the not used time, or 2 outer skin materials import hole 42 all for importing outer skin materials, or, a hole is for importing outer skin materials (its front end is provided with force (forcing) pump to make outer skin materials flow to water dropper direction in the way of having pressure), another hole is for deriving outer skin materials (its rear end no pressure, and it can derive unnecessary material or the pressure for outer skin materials in regulating dropping head) and the material now derived is back to outer skin materials pond by loop. have been surprisingly found that, when described 2nd gap 23 place is just being provided with 2 outer skin materials importing holes 42 by the described wall in barrel-shaped interconnecting piece 4, and hole for import outer skin materials and another hole for deriving outer skin materials time, higher than only there being the design in an outer skin materials importing hole 42, (arrange a ball roundness average when an outer skin materials imports hole is in 0.88��0.92 scope to the ball roundness of dripping obtained so significantly, and when arranging one as mentioned above and enter 2 outer skin materials importing holes that goes out, dripping ball roundness is (two numerical ranges are 6 kinds of different material trial values) in 0.97��0.99 scope, these numerical value are all import hole 41 at intermediate material also to enter 2 outer skin materials out such as above-mentioned one and import the water dropper that hole 42 modes arrange and obtain).
According to the example of the present invention for the preparation of the water dropper of multilayer pill, it is the water dropper dripping balls for the preparation of three layers. Now intermediate material imports part 2 only.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, its internal layer material imports part 1, intermediate material imports part 2 and outer skin materials imports part 3 three and reduces gradually to be formed at bottom bore and drip a mouth 5.
As shown in Figure 3, according to the example of the present invention for the preparation of the water dropper of multilayer pill, when looking up from its underpart, seen mouth 5 edges are three concentric(al) circless, import part 1 bottom by internal layer material successively from the inside to the outside, intermediate material imports part 2 bottom, outer skin materials imports part 3 bottom three and forms, innermost layer is used for the outflow of internal layer material, middle layer is used for the outflow of intermediate material, and outermost layer is used for the outflow of outer skin materials.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, as shown in Figure 3, when looking up from its underpart seen water dropper along in three concentric(al) circless, forming innermost layer region 15, interlayer region 25, outermost region 35. when using 6 kinds of different materials to test, have been found that, innermost layer region 15 area: interlayer region 25 area: when selecting in the big mobility scale of outermost region 35 areas=1:0.5��5:0.8��10, all can prepare the ball (adopting intermediate material to import hole 41 and outer skin materials importing hole 42 all to adopt as above-mentioned enters a test-results outing the design in 2 holes and obtaining) to drip ball roundness and being greater than 0.96, regrettable is, adopt three layers of design (Fig. 4 of such as CN100506093C-200480028272.1 of some documents, Fig. 1 of CN201750916U-201020224428.1, Fig. 3 of CN104219951A-201280067210.1) test same material, adjust innermost layer region area in these literature protocol: interlayer region area: when outermost region area is also selected in the big mobility scale of 1:0.5��5:0.8��10, gained drips ball roundness all in 0.67��0.86 scope, their dripping successful ground is not as good as the present invention program.
According to the example of the present invention for the preparation of the water dropper of multilayer pill, it can be used in conventional multilayer drilling pill device, such as, as said in CN100506093C-200480028272.1, CN201750916U-201020224428.1, CN104219951A-201280067210.1. In an example, the water dropper of the present invention is used for multilayer pill equipment. These multilayer pill equipment generally include the temperature controlling system of the material suppling system, control material and the water dropper temperature that are connected with water dropper.
Such as Fig. 4 example, present invention also offers a kind of multilayer pill equipment, comprising:
Water dropper (particularly the water dropper of such as first aspect present invention) 101;
The material supply pipeline 102 being connected with described water dropper;
Material supply fills with 103;
For material supply filling 103, material supply pipeline 102 and water dropper 101 provide temperature controlled temperature controlling system (such as comprising blower fan 104, hot-blast pipe line 105, well heater 106, temp probe 107, volume damper 108); With
Drip ball receiving trap 109.
Filling with a set of material supply pipeline and material supply due to one layer of water dropper and is connected, therefore a set of temperature controlling system can control a set of water dropper, material supply pipeline and material supply filling. Certainly, it is also possible to adopt a set of temperature controlling system to fill with control many covers water dropper, material supply pipeline and material supply. In Fig. 4, example is adopt a set of temperature controlling system to control a set of water dropper, material supply pipeline and material supply to fill with.
An example according to multilayer pill equipment of the present invention, wherein said temperature controlling system is circulating air Controlling System.
An example according to multilayer pill equipment of the present invention, wherein said ball receiving trap 109 comprises a ball cooling end and drips a ball recovery portion (do not express in Fig. 4 and distinguish both this). Described ball cooling end adopts whiteruss etc. usually. This also well known to a person skilled in the art.
Using multilayer pill equipment of the present invention to prepare multilayer pill (such as three layers of pill) is easily realize, and composition graphs 4 is illustrated, and this preparation process is usually looked into and comprised the steps: 1 with it) prepare the material dripping each layer of ball respectively;
2) each layer material adds to corresponding material supply respectively fills with in 103, and each material supply is filled with 103 material inlets importing part respectively to the material of the corresponding layer of water dropper 101 (particularly the water dropper of such as first aspect present invention) and connected;
3) start-up temperature Controlling System (such as comprising blower fan 104, hot-blast pipe line 105, well heater 106, temp probe 107, volume damper 108), the temperature of the material in material supply filling 103, material supply pipeline 102 and water dropper 101 is made to control in the prescribed value or scope of this material;
4) after each layer temperature of charge balances, open and drip ball dripping program, the ball that drips dripping is dripped in ball receiving trap 109.
The above embodiment is only the preferred embodiment lifted for absolutely proving the present invention, and protection scope of the present invention is not limited to this. The equivalent replacement that those skilled in the art do on basis of the present invention or conversion, all within protection scope of the present invention. Protection scope of the present invention is as the criterion with claim book.
Claims (10)
1. the water dropper for the preparation of multilayer pill, it is characterised in that, it is the integrated structure can dismantled and assemble, comprising:
I) internal layer material imports part, it is generally in nail-like, the upper end bulb that the internal layer material of this nail-like imports part is provided with the first interface for being connected with interconnecting piece, the internal layer material of this nail-like imports part and arranges a through internal layer through hole from the top to the bottom, and this internal layer through hole flows to bottom from the upper end that this internal layer material imports part for making internal layer material and flows out;
Ii) intermediate material imports part, it is generally in nail-like, the upper end bulb that the intermediate material of this nail-like imports part is provided with the 2nd interface for being connected with interconnecting piece, and the intermediate material of this nail-like imports part and arranges a through intermediate throughholes from the top to the bottom; The external diameter that internal layer material described in the aperture ratio of this intermediate throughholes imports the lower end needle like section of part is thick, and the lower end needle like section that described internal layer material imports part can insert in this intermediate throughholes;
Iii) outer skin materials imports part, and it is generally in inverted hollow circular cone shape, and the upper end bulb that the outer skin materials of this circular cone shape imports part is provided with the 3rd interface for being connected with interconnecting piece; The hollow parts that the outer skin materials of this circular cone shape imports part inside is thicker than the external diameter of the lower end needle like section of described intermediate material importing part, and the lower end needle like section that described intermediate material imports part can insert in the hollow parts that this outer skin materials imports part inside;
Iv) interconnecting piece, it is generally in barrel-shaped, its inside is disposed with the first interface, the 2nd interface and the 3rd interface from top to bottom, to be respectively used to importing part with internal layer material, intermediate material imports part and outer skin materials importing part three is connected so that described three kinds of materials import part and connect into coaxial unitary form in this interconnecting piece inside.
2. the water dropper for the preparation of multilayer pill according to claim 1, it is characterised in that:
Described first interface, the 2nd interface and the 3rd interface are in being selected from following structure independently of one another: helicitic texture, patch structure;
After described internal layer material imports part, intermediate material importing part, outer skin materials importing part and interconnecting piece assembling, there is a gap between the upper edge of the upper end bulb of the lower edge of the upper end bulb of the internal layer material importing part of described nail-like and the intermediate material importing part of described nail-like, this gap is called the first gap;
Described first gap location is just being provided with one or more hole imported for intermediate material by the described wall in barrel-shaped interconnecting piece, this/this some holes is called that intermediate material imports hole;
After described internal layer material imports part, intermediate material importing part, outer skin materials importing part and interconnecting piece assembling, there is a gap between the upper edge of the upper end bulb of the lower edge of the upper end bulb of the intermediate material importing part of described nail-like and the outer skin materials importing part of described circular cone shape, this gap is called the 2nd gap; And/or
Described 2nd gap location is just being provided with one or more hole imported for outer skin materials by the described wall in barrel-shaped interconnecting piece, this/this some holes is called that outer skin materials imports hole.
3. the water dropper for the preparation of multilayer pill according to claim 1, it is characterised in that:
The lower edge that described internal layer material imports part, intermediate material importing part imports part three with outer skin materials is concordant;
The upper end of described internal layer through hole is connected with internal layer material supplying device, to provide uninterrupted internal layer material;
Wherein one or more described intermediate material imports hole and is connected with intermediate material supply device, to provide uninterrupted intermediate material;
Wherein one or more described outer skin materials imports hole and is connected with outer skin materials supply device, to provide uninterrupted outer skin materials;
It comprises an intermediate material and imports part, and drips ball for the preparation of three layers;
It comprises two intermediate materials and imports part, and drips ball for the preparation of four layers; And/or
It comprises 1��4 intermediate material and imports part; Preferential, it comprises 1��3 intermediate material and imports part; Preferential, it comprises 1��2 intermediate material and imports part; Preferential, it comprises 1 intermediate material and imports part.
4. the water dropper for the preparation of multilayer pill according to claim 1, it is characterised in that:
Described first gap location is just being provided with 1��3 intermediate material importing hole by the described wall in barrel-shaped interconnecting piece; Preferably being provided with 2 intermediate materials and import hole, one of them hole is for importing intermediate material, and another hole is for subsequent use, can block with stifled head in the not used time; Or 2 intermediate materials import Kong Jun for importing intermediate material; Or, a hole is for importing intermediate material (its front end is provided with force (forcing) pump to make intermediate material flow to water dropper direction in the way of having pressure), another hole is for deriving intermediate material (its rear end no pressure, and it can derive unnecessary material or the pressure for intermediate material in regulating dropping head) and the material now derived is back to intermediate material pond by loop; And/or
Described 2nd gap location is just being provided with 1��3 outer skin materials importing hole by the described wall in barrel-shaped interconnecting piece. Preferably being provided with 2 outer skin materials and import hole, one of them hole is for importing outer skin materials, and another hole is for subsequent use, can block with stifled head in the not used time; Or 2 outer skin materials import Kong Jun for importing outer skin materials; Or, a hole is for importing outer skin materials (its front end is provided with force (forcing) pump to make outer skin materials flow to water dropper direction in the way of having pressure), another hole is for deriving outer skin materials (its rear end no pressure, and it can derive unnecessary material or the pressure for outer skin materials in regulating dropping head) and the material now derived is back to outer skin materials pond by loop.
5. the water dropper for the preparation of multilayer pill according to claim 1, it is characterised in that:
It is the water dropper dripping ball for the preparation of three layers;
Its internal layer material imports part, intermediate material imports part and outer skin materials importing part three reduces a formation droplet mouth gradually at bottom bore;
Along in three concentric(al) circless seen mouth when looking up from its underpart, import part bottom by internal layer material successively from the inside to the outside, intermediate material imports part bottom, outer skin materials imports part bottom three and forms, innermost layer is used for the outflow of internal layer material, middle layer is used for the outflow of intermediate material, and outermost layer is used for the outflow of outer skin materials;
Along in three concentric(al) circless, forming innermost layer region, interlayer region, outermost region seen water dropper when looking up from its underpart;
Along in three concentric(al) circless seen water dropper when looking up from its underpart, form innermost layer region, interlayer region, outermost region, the area ratio of this three and innermost layer region area: interlayer region area: outermost region area=1:0.5��5:0.8��10.
6. a multilayer pill equipment, it is characterised in that, comprising:
Water dropper (particularly the water dropper of such as claim 1-5 arbitrary);
The material supply pipeline being connected with described water dropper;
Material supply is filled with;
For material supply filling, material supply pipeline and water dropper provide temperature controlled temperature controlling system; With
Drip ball receiving trap.
7. a multilayer pill equipment, it is characterised in that, wherein said a set of temperature controlling system controls a set of water dropper, material supply pipeline and material supply individually and fills with.
8. a multilayer pill equipment, it is characterised in that, wherein said temperature controlling system is circulating air Controlling System.
9. a multilayer pill equipment, it is characterised in that, wherein said ball receiving trap comprises a ball cooling end and drips a ball recovery portion.
10. preparing the method for multilayer pill (such as three layers of pill), it comprises the steps:
1) material of each layer of ball is dripped in preparation respectively;
2) being added to by each layer material in the filling of corresponding material supply respectively, the material inlet that the filling of each material supply imports part to the material of the corresponding layer of water dropper (particularly the water dropper of such as claim 1-5 arbitrary) respectively connects;
3) start-up temperature Controlling System, makes the temperature of the material in material supply filling, material supply pipeline and water dropper control in the prescribed value or scope of this material;
4) after each layer temperature of charge balances, open and drip ball dripping program, the ball that drips dripping is dripped in ball receiving trap.
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| CN201610187580.9A CN105616164B (en) | 2016-03-30 | 2016-03-30 | The preparation process of multilayer pill equipment and its component and multilayer pill |
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| CN201610187580.9A CN105616164B (en) | 2016-03-30 | 2016-03-30 | The preparation process of multilayer pill equipment and its component and multilayer pill |
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| CN106333860A (en) * | 2016-09-16 | 2017-01-18 | 深圳万和制药有限公司 | Method for improving multilayer dropping pill structure and device using in method |
| CN106924046A (en) * | 2017-04-24 | 2017-07-07 | 中国科学技术大学 | Medicine-carrying capsule prepares shower nozzle and medicine-carrying capsule preparation facilities |
| CN109965327A (en) * | 2019-04-04 | 2019-07-05 | 盐城市元炟科技有限公司 | A kind of seamless soft capsule dripping pill device and dripping forming method |
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| CN201750916U (en) * | 2010-06-07 | 2011-02-23 | 湖北中烟工业有限责任公司 | Three-layer soft capsule dropper head device |
| CN204637003U (en) * | 2015-02-11 | 2015-09-16 | 临沂大学 | A kind of temperature control pill dripping machine of serialization charging |
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| JP2001000509A (en) * | 1999-06-25 | 2001-01-09 | Kao Corp | Production of capsule particle |
| CN101259110A (en) * | 2007-03-06 | 2008-09-10 | 天津天士力制药股份有限公司 | Multi-layer drug delivery system drop pill, preparation and device thereof |
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| CN106333860A (en) * | 2016-09-16 | 2017-01-18 | 深圳万和制药有限公司 | Method for improving multilayer dropping pill structure and device using in method |
| CN106333860B (en) * | 2016-09-16 | 2021-10-19 | 深圳万和制药有限公司 | Method for improving multi-layer dripping pill structure and its used equipment |
| CN106924046A (en) * | 2017-04-24 | 2017-07-07 | 中国科学技术大学 | Medicine-carrying capsule prepares shower nozzle and medicine-carrying capsule preparation facilities |
| CN109965327A (en) * | 2019-04-04 | 2019-07-05 | 盐城市元炟科技有限公司 | A kind of seamless soft capsule dripping pill device and dripping forming method |
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|---|---|
| CN105616164B (en) | 2019-05-31 |
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