CN105597083B - A kind of pair of liver kidney has health food of auxiliary protection function and preparation method thereof - Google Patents
A kind of pair of liver kidney has health food of auxiliary protection function and preparation method thereof Download PDFInfo
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- CN105597083B CN105597083B CN201610068849.1A CN201610068849A CN105597083B CN 105597083 B CN105597083 B CN 105597083B CN 201610068849 A CN201610068849 A CN 201610068849A CN 105597083 B CN105597083 B CN 105597083B
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention relates to the health foods and preparation method thereof that a kind of pair of liver kidney has auxiliary protection function, belong to food processing technology field.Its raw material of the health food includes ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni, cordyceps mycelia powder, whey protein concentrate, soybean protein isolate, VA, VB1、VB2、VB6, xylo-oligosaccharide, lycopene, apple polyphenol.The health food passes through selection raw material meticulously, and scientific composition not only has the effect of auxiliary protection function to liver kidney, also has prevention " three high ", anti-oxidant, anti-aging, improves the health-care effects such as immunity.
Description
Technical field
The present invention relates to the health foods and preparation method thereof that a kind of pair of liver kidney has auxiliary protection function, belong to food processing
Technical field.
Background technique
China is hepatopathy big country, in recent years virus hepatitis, fatty liver, alcoholic liver disease, medicamentous liver lesion and liver cancer
Etc. hepatopathys have become threaten human health one of principal disease.And since living habit and social custom problem lead to some people
Long-term alcohol is even drunk beyond one's capacity, and alcohol has become the second largest killer of liver for being only second to virus hepatitis.In heavy drinker
80% or more has a degree of fatty liver, and 10%~35% can develop into alcoholic hepatitis, and 10%~20% will develop into liver
Hardening, and alcoholic cirrhosis prognosis is poor, survival rate is about 23~50% within 5 years.Investigation points out that China's alcoholic liver disease is in institute
There is the ratio in hepatopathy to have and increase trend year by year, but specific treatment medicine there is no to alcoholic liver disease at present.
The kidney being the origin of congenital constitution.When kidney deficiency, essence, gas, the yin, yang void of kidney decline deficiency, be easy to appear body is thin, spirit not
Vibration, soreness and weakness of waist and knees, dizzy tinnitus, insomnia and dreamful sleep, amnesia of sleeping less, spermatorrhea frequent micturition, hectic fever night sweat, dry or the cold limb cold of shape, asthma are inverse
Etc. symptoms, cause the immunocompetence of people to reduce.And the microcirculqtory system of kidney the problem of also blocking, i.e., kidney network can be presented
It is obstructed, it is the pathogenetic pathologic basis of kidney.Renal insufficiency is as caused by many reasons, and glomerulus seriously destroys, and makes body
Excretion metabolism waste and adjust Water-Electrolyte, in terms of the clinical syndrome that gets muddled after group.
Therefore, the health food that a kind of pair of liver kidney has auxiliary protection function is researched and developed, liver kidney damage is prevented by diet
Wound mitigates the symptom of hepatic and kidney function obstacle person, is very suitable to China's national situation and the needs of patient.Such health food market is also
Sizable development space.
Summary of the invention
In order to solve the above technical problems, it is an object of that present invention to provide the health care foods that a kind of pair of liver kidney has auxiliary protection function
Product and preparation method thereof.For the health food by selecting raw material meticulously, scientific composition not only has auxiliary protection function to liver kidney
Effect also has prevention " three high " (referring to hypertension, hyperglycemia (diabetes) and hyperlipidemia), anti-oxidant, anti-aging, improves
The health-care effects such as immunity.
Realize that the object of the invention technical solution is as follows:
A kind of pair of liver kidney has the health food of auxiliary protection function, and raw material includes ganoderma lucidum, Moringa, cassia seed, Maca, mountain
The fruit of medicinal cornel, cordyceps mycelia powder, whey protein concentrate, soybean protein isolate, VA, VB1、VB2、VB6, xylo-oligosaccharide, lycopene,
Apple polyphenol.
Preferably, its raw material includes 10-200 parts of ganoderma lucidum, 10-150 parts of Moringa, Cassia to the health food in parts by weight
It is 5-50 parts sub-, Maca 10-150 parts, it is 10-200 parts of Fructus Corni, 5-50 parts of cordyceps mycelia powder, 5-50 parts of whey protein concentrate, big
5-50 parts of beans protein isolate, 0.0001-0.0005 parts of VA, VB10.0005-0.005 parts, VB20.0005-0.005 parts, VB6
0.0005-0.005 parts, 0.1-5 parts of xylo-oligosaccharide, 0.01-0.1 parts of lycopene, 0.01-0.1 parts of apple polyphenol.
It is further preferred that its raw material includes 50-150 parts of ganoderma lucidum, Moringa 20-100 to the health food in parts by weight
Part, 10-40 parts of cassia seed, Maca 20-100 parts, 50-150 parts of Fructus Corni, 10-40 parts of cordyceps mycelia powder, whey protein concentrate
10-40 parts, 10-40 parts of soybean protein isolate, 0.0001-0.0005 parts of VA, VB10.001-0.005 parts, VB2 0.001-
0.005 part, VB60.001-0.005 parts, 1-5 parts of xylo-oligosaccharide, 0.02-0.08 parts of lycopene, apple polyphenol 0.02-0.08
Part.
Preferably, the health food in parts by weight its raw material include 120 parts of ganoderma lucidum, 80 parts of Moringa, 15 parts of cassia seed,
35 parts of Maca, 70 parts of Fructus Corni, 20 parts of cordyceps mycelia powder, 15 parts of whey protein concentrate, 25 parts of soybean protein isolate, VA
0.0003 part, VB10.002 part, VB20.003 part, VB60.002 part, 3 parts of xylo-oligosaccharide, 0.05 part of lycopene, apple it is more
0.03 part of phenol.
In above-mentioned health food, it is preferable that the protein content in the whey protein concentrate is >=80% (with dry weight
Meter)；Protein content >=99% in soybean protein isolate；Lycopene content >=10% in lycopene；Apple polyphenol
In apple polyphenol content >=50%.
The parts by weight can be the unit of weight well known in the art such as μ g, mg, g, kg, be also possible to its multiple, and such as 1/
10,1/100,10 times, 100 times etc..
The above-mentioned health food for having auxiliary protection function to liver kidney, wherein ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni,
Cordyceps mycelia powder, whey protein concentrate, soybean protein isolate, VA, VB1、VB2、VB6, xylo-oligosaccharide, lycopene, apple it is more
Phenol is as active raw materials；Preferably, its raw material of above-mentioned health food or auxiliary material further include pharmaceutically or on food or health care
Acceptable carrier on food.
Preferably, the health food is formed into oral preparation；It include: capsule, granule, tablet, packed medicinal tea, powder
Agent etc.；More preferably granule.
It is further preferred that its raw material of the health food or auxiliary material further include microcrystalline cellulose, magnesium stearate.
The present invention also provides the preparation methods of above-mentioned health food, method includes the following steps: weighing according to the proportion each
Ingredient mixes, is prepared into preparation according to conventional preparation method.
Preferably, above-mentioned health food preparation method the following steps are included:
1) ingredient；Required raw material (including ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni, Chinese caterpillar fungus hypha are weighed according to the ratio
Body powder, whey protein concentrate, soybean protein isolate, VA, VB1、VB2、VB6, xylo-oligosaccharide, lycopene, apple polyphenol etc.)；
2) after mixing ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni, the 50%-90% ethyl alcohol of 5-10 times of weight is added to return
Stream extracts 1-3 times, 0.5-3.0 hours each, filtration, and filter residue is spare；Merging filtrate concentrates the filtrate to clear cream (relative density
For 1.10-1.30,30 DEG C), ethyl alcohol, which is added, makes alcohol content up to 70%-75%, obtains solution I；
3) water of 5-15 times of weight is added to decoct 1-3 times filter residue obtained by step 2), 0.5-2 hours each, collecting decoction, filter
It crosses, concentrates the filtrate to clear cream (relative density 1.10-1.30,30 DEG C), add ethyl alcohol to make alcohol content up to 70%-75%, obtain molten
Liquid II；
4) merge the solution I and solution II, stir evenly, stand, it is (relatively close to be concentrated into clear cream for filtration, filtrate recycling ethanol
Spending is 1.10-1.30,30 DEG C)；Remaining raw material (cordyceps mycelia powder, whey protein concentrate, soybean separation protein is added by formula
White, VA, VB1、VB2、VB6, xylo-oligosaccharide, lycopene, apple polyphenol etc.) and appropriate amount of auxiliary materials suitable dosage form is made.It is preferred that
Ground is added appropriate amount of auxiliary materials microcrystalline cellulose, magnesium stearate, granule is made.
Specifically, above-mentioned health food preparation method the following steps are included:
1) ingredient；Required raw material (including ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni, Chinese caterpillar fungus hypha are weighed according to the ratio
Body powder, whey protein concentrate, soybean protein isolate, VA, VB1、VB2、VB6, xylo-oligosaccharide, lycopene, apple polyphenol etc.)；
2) by ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni mix after, with 70%-75% alcohol reflux extract 2 times, the 1st
Secondary that 8 times of w ethanols extraction 3h are added, 6 times of w ethanols of the 2nd addition extract 1h, filter, filter residue is spare；Merging filtrate, will
Filtrate is concentrated into clear cream (relative density 1.10-1.30,30 DEG C), and ethyl alcohol, which is added, makes alcohol content up to 70%-75%, obtains solution I；
3) filter residue obtained by step 2) is added water to cook 2 times, 10 times of weight waters of the 1st addition decoct 2h, the 2nd 8 times of addition
W ethanol extracts 1h, collecting decoction, and filtration concentrates the filtrate to clear cream (relative density 1.10-1.30,30 DEG C), adds second
Alcohol makes alcohol content up to 70%-75%, obtains solution II；
4) merge the solution I and solution II, stir evenly, stand, it is (relatively close to be concentrated into clear cream for filtration, filtrate recycling ethanol
Spending is 1.10-1.30,30 DEG C)；Remaining raw material (cordyceps mycelia powder, whey protein concentrate, soybean separation protein is added by formula
White, VA, VB1、VB2、VB6, xylo-oligosaccharide, lycopene, apple polyphenol etc.) and appropriate amount of auxiliary materials suitable dosage form is made.It is preferred that
Ground is added appropriate amount of auxiliary materials microcrystalline cellulose, magnesium stearate, granule is made.
Unless otherwise specified, concentration of alcohol of the present invention refers both to volumetric concentration.
It is demonstrated experimentally that the present invention extracts traditional Chinese medicinal material raw materials using above-mentioned technique, Chinese medicine original is utmostly remained
The effective ingredient of material, and the effective component extracted is easiest to be absorbed by the body, and enhances the absorption of drug, so as to avoid invalid
Ingredient interferes the problem of drug effect.
Ganoderma lucidum is mild-natured, bitter, nontoxic, and master ties in the heart, invigorating heart gas, bowl spares, increases wisdom, does not forget, and long term usage is made light of one's life by commiting suicide not always, macrobiosis
Angle.Ganoderma lucidum has protective effect to hepatic injury caused by a variety of physical and chemical and biological factors.No matter liver damage occur before or
After generation, liver can all be protected by taking ganoderma lucidum, mitigate hepatic injury.Ganoderma lucidum can promote metabolism of the liver to drug, poisonous substance, in
Virus hepatitis has exact curative effect.Especially chronic hepatitis, ganoderma lucidum can obviously eliminate the diseases such as dizzy, out of strength, nauseous, uncomfortable liver area
Shape, and liver function can be effectively improved, so that indices is tended to be normal.Ganoderma lucidum can be used for treating slow poisoning, all kinds of Chronic Livers
Inflammation, cirrhosis, hepatosis.Ganoderma lucidum kidney tonifying, strengthening the essence, wind-dispelling；It is adjustable immune function, improves body major organ systems,
Such as function of the heart, lung, liver, kidney.Studies have shown that ganoderma lucidum can promote the nucleic acid of serum, liver and marrow and the biology of protein
Synthesis has good kidney tonifying effect.
Moringa (Moringa) is also known as drumstick tree (Drumstick tree), is Capparales Moringaceae, Moringa arbor.
Moringa of the present invention is preferably moringa seeds, i.e. the seed of Moringa tree, is had in fields such as food, medicine, health care, cosmetics
Good application value because be rich in seed oil of Moringa oleigera, reduce blood lipid, blood pressure, weight-reducing, adjust stomach, protect liver guard against
Wine, enhancing human immunity aspect all has significant curative effect.
Cassia seed is the dry mature seed of legume cassia or little cassia tora.Cassia seed bitter, sweet, salty, cold nature enters
Liver, kidney, large intestine channel；Constipation and hyperlipidemia, hypertension are treated in relax bowel and defecation, lipid-loweringing improving eyesight.It clears liver and improve vision, sharp water defaecation has slow
The effect of rushing down, reducing blood pressure and blood fat.
Maca (scientific name: Lepidium meyenii Walp), (Spanish: Maca).It mainly produces in South America peace the
This mountain range and Chinese yunnan Lijing are a kind of crucifers.Due to containing the nutrition there are many balanced and reasonable in Maca
And a variety of biologically active secondary metabolites, therefore, Maca has plurality kinds of health care and therapeutic efficiency and effect, tradition
On can be used for enhancing energy, improve fertility, treatment climacteric syndrome, rheumatism, depression, anemia, in addition, it also has
There is the effects of anticancer and anti-leukocythemia.
Fructus Corni nature and flavor are sour, puckery, slightly warm in nature.Channel tropism returns liver and kidney channel.Fructus Corni tonifies the liver and kidney；Astringing and avoiding visceroptosis；It can mend
The yin of liver kidney, and energy kidney-replenishing, are the panaceas of the tonifying both YIN and YANG of this medicine is mild simply.
Cordyceps sinensis is sweet in flavor warm-natured, protects lung kidney-nourishing, qi-restoratives damage, mends marrow, hemostasis and phlegm, only consumptive disease cough.Cordyceps sinensis can mitigate chronic
Renal lesions improve renal function, mitigate damage of the toxicant to kidney, have anti-renal failure effect.Cordyceps mycelia powder, also known as
Cordyceps sinensis powder, with cordyceps sinensis have the function of similar ingredient and.Cordyceps mycelia powder of the present invention is preferably aweto mycelium
Powder, can be by prior art preparation, also buyable commercial prod.
Lycopene is a kind of natural pigment contained in plant.It is primarily present in the ripening fruits of plant of Solanaceae tomato
In.It is most one of the powerful antioxidant being found in the plant of nature at present.Science proof, the intracorporal singlet oxygen of people
It is the arch-criminal for encroaching on human body self immune system with oxygen radical.The effect of lycopene removing free radical, outclass other
Carotenoid and vitamin E, singlet-oxygen quenching rate constant are 100 times of vitamin E.It can with effectively preventing because
Aging, various diseases caused by immunity degradation.
Whey protein concentrate of the present invention, soybean protein isolate, VA, VB1、VB2、VB6, xylo-oligosaccharide, lycopene,
The equal buyable commercial prod of the supplementary materials such as apple polyphenol.
The present invention is guidance with Chinese Traditional Medicine theory, meticulous from health angle in conjunction with modern medicine study routine
Raw material is selected, scientific composition reaches the health-care effect of auxiliary protection liver kidney, and also there is prevention " three high " (to refer to hypertension, hyperglycemia
(diabetes) and hyperlipidemia), it is anti-oxidant, delay senescence, improve the health-care effects such as immunity.The present invention focuses on human body entirety
Not only there is the health care of auxiliary protection liver kidney to imitate for conditioning and inherent conditioning, the healthy food products developed in conjunction with health
Fruit, additionally it is possible to promote the good health and a long life of human body.
The principles of formulating prescriptions of the present invention: being monarch with ganoderma lucidum, Fructus Corni, using cassia seed, Maca as minister, with Moringa, cordyceps mycelia
Powder is assistant, is to make with lycopene, apple polyphenol, cooperates whey protein concentrate, soybean protein isolate, VA, VB1、VB2、VB6, it is low
Xylan improves product protection liver kidney function effect with collaboration.All medicines share, long memorial liver protects kidney, relieve stagnation analgesic altogether, and protecting liver, lowering enzymes reconcile
The effect of qi and blood, property of the present invention is peaceful, is conducive to long term usage, no adverse side effect.
Selected raw material of the present invention improves human five internal organs, and comprehensive function reaches the health-care effect of protection liver kidney.Wherein pass through tune
Reason heart keeps the motive vigorous, and painstaking effort are full；Liver storing blood keeps qi and blood gentle by improving liver, and blood operation is sufficient, red complexion
Moisten gloss；The spleen being the foundation of acquired constitution, source of generating QI and blood；By function of spleen and stomach regulating, make the strong fortune of its function, qi and blood is vigorous；Lung governing skin and hair,
Enable qi-blood-body fluid spreading whole body by improving lung；Kidney controlling essence storage keeps kidney essense full by conditioning kidney, when kidney qi is vigorous,
Function of five internal organs will also operate normally, and qi and blood is vigorous, and appearance does not wane.
Health food of the present invention is a kind of to follow the fashion, again take into account in a manner of traditional product drink, to reach in satisfied
It is beneficial to the purpose of person in middle and old age and sub-health population health care.Health food action temperature of the present invention and, efficacy stability is nontoxic secondary to make
With suitable long-term drinking.The study found that taking health food of the present invention for a long time also there is prevention " three high " (to refer to hypertension, high blood
Sugared (diabetes) and hyperlipidemia), it is anti-oxidant, delay senescence, improve the health-care effects such as immunity.
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..It is not specified in embodiment specific
Technology or conditions person, described technology or conditions according to the literature in the art, or carried out according to product description.It is used
Production firm person is not specified in reagent or instrument, is the conventional products that can be commercially available by regular distributor.Following embodiment
And in comparative example, whey protein concentrate purchased from inspiring confidence in (Tianjin) International Trading Company Ltd in day pool, protein content be 80% (with
Dry weight meter)；Soybean protein isolate is purchased from Shandong YuWang Industry Co., Ltd, protein content >=99%；Lycopene is purchased from west
Pacify Rayleigh Biotechnology Co., Ltd, lycopene content >=10%；Apple polyphenol is purchased from the biological Co., Ltd of Zhejiang day grass, apple
Fruit polyphenol content >=50%.
Embodiment 1
A kind of pair of liver kidney has the health food of auxiliary protection function, and in parts by weight, raw material includes 200 parts of ganoderma lucidum, peppery
It is 150 parts of wood, 50 parts of cassia seed, 150 parts of Maca, 200 parts of Fructus Corni, 50 parts of cordyceps mycelia powder, 50 parts of whey protein concentrate, big
5-50 parts of beans protein isolate, 0.0001-0.0005 parts of VA, VB10.0005-0.005 parts, VB20.0005-0.005 parts, VB6
0.0005-0.005 parts, 0.1-5 parts of xylo-oligosaccharide, 0.01-0.1 parts of lycopene, 0.01-0.1 parts of apple polyphenol.
Embodiment 2
A kind of pair of liver kidney has the health food of auxiliary protection function, and in parts by weight, raw material includes 10 parts of ganoderma lucidum, Moringa
10 parts, 5 parts of cassia seed, 10 parts of Maca, 10 parts of Fructus Corni, 5 parts of cordyceps mycelia powder, 5 parts of whey protein concentrate, soybean separation protein
White 5 parts, 0.0001 part of VA, VB10.0005 part, VB20.0005 part, VB60.0005 part, 0.1 part of xylo-oligosaccharide, tomato it is red
Plain 0.01,0.01 part of apple polyphenol.
Embodiment 3
A kind of pair of liver kidney has the health food of auxiliary protection function, and in parts by weight, raw material includes 50 parts of ganoderma lucidum, Moringa
20 parts, 10 parts of cassia seed, 20 parts of Maca, 50 parts of Fructus Corni, 10 parts of cordyceps mycelia powder, 10 parts of whey protein concentrate, soybean point
From protein 10 part, 0.0001 part of VA, VB10.001 part, VB20.001 part, VB60.001 part, 1 part of xylo-oligosaccharide, tomato it is red
0.02 part, 0.02 part of apple polyphenol of element.
Embodiment 4
A kind of pair of liver kidney has the health food of auxiliary protection function, and in parts by weight, raw material includes 150 parts of ganoderma lucidum, peppery
It is 100 parts of wood, 40 parts of cassia seed, 100 parts of Maca, 150 parts of Fructus Corni, 40 parts of cordyceps mycelia powder, 40 parts of whey protein concentrate, big
40 parts of beans protein isolate, 0.0005 part of VA, VB1.005 part, VB20.005 part, VB60.005 part, 5 parts of xylo-oligosaccharide, tomato
0.08 part of red pigment, 0.08 part of apple polyphenol.
Embodiment 5
A kind of pair of liver kidney has the health food of auxiliary protection function, and in parts by weight, raw material includes 120 parts of ganoderma lucidum, peppery
Wooden 80 parts, 15 parts of cassia seed, 35 parts of Maca, 70 parts of Fructus Corni, 20 parts of cordyceps mycelia powder, 15 parts of whey protein concentrate, soybean
25 parts of protein isolate, 0.0003 part of VA, VB10.002 part, VB20.003 part, VB60.002 part, 3 parts of xylo-oligosaccharide, tomato
0.05 part of red pigment, 0.03 part of apple polyphenol.
Embodiment 6
A kind of pair of liver kidney has the health food of auxiliary protection function, and in parts by weight, raw material includes 100 parts of ganoderma lucidum, peppery
Wooden 60 parts, 18 parts of cassia seed, 55 parts of Maca, 80 parts of Fructus Corni, 25 parts of cordyceps mycelia powder, 25 parts of whey protein concentrate, soybean
15 parts of protein isolate, 0.0002 part of VA, VB10.003 part, VB20.002 part, VB60.003 part, 2 parts of xylo-oligosaccharide, tomato
0.03 part of red pigment, 0.05 part of apple polyphenol.
Embodiment 7
A kind of pair of liver kidney has the health food of auxiliary protection function, is formulated same as Example 1, the system of the health food
Preparation Method the following steps are included:
1) ingredient；Required raw material is weighed according to the ratio；
2) after mixing ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni, 90% alcohol reflux of 5 times of weight is added to extract 3
It is secondary, it 0.5 hour every time, filters, filter residue is spare；Merging filtrate concentrates the filtrate to clear cream (1.30,30 DEG C of relative density),
Ethyl alcohol, which is added, makes alcohol content up to 75%, obtains solution I；
3) water of 5 times of weight is added to decoct 3 times filter residue obtained by step 2), 0.5 hour every time, collecting decoction, filtration will filter
Liquid is concentrated into clear cream (1.30,30 DEG C of relative density), adds ethyl alcohol to make alcohol content up to 75%, obtains solution II；
4) merge the solution I and solution II, stir evenly, stand, it is (relatively close to be concentrated into clear cream for filtration, filtrate recycling ethanol
Degree is 1.30,30 DEG C)；By formula be added remaining raw material (cordyceps mycelia powder, whey protein concentrate, soybean protein isolate, VA,
VB1、VB2、VB6, xylo-oligosaccharide, lycopene, apple polyphenol etc.) active mixture is made；100 parts of the active mixture is taken, is added
Adding 12.5 parts of maltodextrin, 55.5 parts of microcrystalline cellulose, be uniformly mixed, adds ethanol in proper amount solution softwood, 16 meshes are pelletized, and 60
DEG C drying, 12 mesh sieves, that is, granule.
20g/ bags of product specification；It is recommended that eating method and amount: 3 times a day, 1 bag every time, warm boiled water；Shelf-life
24 months；Storage practice room temperature, ventilation, it is dry at.
Embodiment 8
A kind of pair of liver kidney has the health food of auxiliary protection function, is formulated same as Example 2, the system of the health food
Preparation Method the following steps are included:
1) ingredient；Required raw material is weighed according to the ratio；
2) after mixing ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni, 50% alcohol reflux of 10 times of weight is added to extract 1
It is secondary, it 3.0 hours every time, filters, filter residue is spare；Merging filtrate concentrates the filtrate to clear cream (1.10,30 DEG C of relative density),
Ethyl alcohol, which is added, makes alcohol content up to 70%, obtains solution I；
3) water of 15 times of weight is added to decoct 1 time filter residue obtained by step 2), 2 hours every time, collecting decoction, filtration will filter
Liquid is concentrated into clear cream (1.10,30 DEG C of relative density), adds ethyl alcohol to make alcohol content up to 70%, obtains solution II；
4) merge the solution I and solution II, stir evenly, stand, it is (relatively close to be concentrated into clear cream for filtration, filtrate recycling ethanol
Degree is 1.10,30 DEG C)；By formula be added remaining raw material (cordyceps mycelia powder, whey protein concentrate, soybean protein isolate, VA,
VB1、VB2、VB6, xylo-oligosaccharide, lycopene, apple polyphenol etc.), active mixture is made；100 parts of the active mixture is taken,
12.5 parts of maltodextrin, 55.5 parts of microcrystalline cellulose to be added, is uniformly mixed, ethanol in proper amount solution softwood is added, 16 meshes are pelletized,
60 DEG C of dryings, 12 mesh sieves, that is, granule.
20g/ bags of product specification；It is recommended that eating method and amount: 3 times a day, 1 bag every time, warm boiled water；Shelf-life
24 months；Storage practice room temperature, ventilation, it is dry at.
Embodiment 9
A kind of pair of liver kidney has the health food of auxiliary protection function, is formulated same as Example 3, the system of the health food
Preparation Method the following steps are included:
1) ingredient；Required raw material is weighed according to the ratio；
2) will ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni mix after, with 70% alcohol reflux extract 2 times, the 1st time plus
Enter 8 times of w ethanols and extract 3h, 6 times of w ethanols of the 2nd addition extract 1h, filter, filter residue is spare；Merging filtrate, by filtrate
It is concentrated into clear cream (1.10,30 DEG C of relative density), ethyl alcohol, which is added, makes alcohol content up to 70%, obtains solution I；
3) filter residue obtained by step 2) is added water to cook 2 times, 10 times of weight waters of the 1st addition decoct 2h, the 2nd 8 times of addition
W ethanol extracts 1h, collecting decoction, and filtration concentrates the filtrate to clear cream (1.10,30 DEG C of relative density), ethyl alcohol is added to make to contain
Alcohol amount obtains solution II up to 70%；
4) merge the solution I and solution II, stir evenly, stand, it is (relatively close to be concentrated into clear cream for filtration, filtrate recycling ethanol
Degree is 1.10,30 DEG C)；By formula be added remaining raw material (cordyceps mycelia powder, whey protein concentrate, soybean protein isolate, VA,
VB1、VB2、VB6, xylo-oligosaccharide, lycopene, apple polyphenol etc.), active mixture is made；100 parts of the active mixture is taken,
12.5 parts of maltodextrin, 55.5 parts of microcrystalline cellulose to be added, is uniformly mixed, ethanol in proper amount solution softwood is added, 16 meshes are pelletized,
60 DEG C of dryings, 12 mesh sieves, that is, granule.
20g/ bags of product specification；It is recommended that eating method and amount: 3 times a day, 1 bag every time, warm boiled water；Shelf-life
24 months；Storage practice room temperature, ventilation, it is dry at.
Embodiment 10
A kind of pair of liver kidney has the health food of auxiliary protection function, is formulated same as Example 5, the system of the health food
Preparation Method the following steps are included:
1) ingredient；Required raw material is weighed according to the ratio；
2) will ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni mix after, with 75% alcohol reflux extract 2 times, the 1st time plus
Enter 8 times of w ethanols and extract 3h, 6 times of w ethanols of the 2nd addition extract 1h, filter, filter residue is spare；Merging filtrate, by filtrate
It is concentrated into clear cream (1.30,30 DEG C of relative density), ethyl alcohol, which is added, makes alcohol content up to 75%, obtains solution I；
3) filter residue obtained by step 2) is added water to cook 2 times, 10 times of weight waters of the 1st addition decoct 2h, the 2nd 8 times of addition
W ethanol extracts 1h, collecting decoction, and filtration concentrates the filtrate to clear cream (1.30,30 DEG C of relative density), ethyl alcohol is added to make to contain
Alcohol amount obtains solution II up to 75%；
4) merge the solution I and solution II, stir evenly, stand, it is (relatively close to be concentrated into clear cream for filtration, filtrate recycling ethanol
Degree is 1.30,30 DEG C)；By formula be added remaining raw material (cordyceps mycelia powder, whey protein concentrate, soybean protein isolate, VA,
VB1、VB2、VB6, xylo-oligosaccharide, lycopene, apple polyphenol etc.), active mixture is made；100 parts of the active mixture is taken,
12.5 parts of maltodextrin, 55.5 parts of microcrystalline cellulose to be added, is uniformly mixed, ethanol in proper amount solution softwood is added, 16 meshes are pelletized,
60 DEG C of dryings, 12 mesh sieves, that is, granule.
20g/ bags of product specification；It is recommended that eating method and amount: 3 times a day, 1 bag every time, warm boiled water；Shelf-life
24 months；Storage practice room temperature, ventilation, it is dry at.
Embodiment 11
A kind of pair of liver kidney has the health food of auxiliary protection function, is formulated same as Example 4, the system of the health food
Preparation Method is the same as embodiment 9.
20g/ bags of product specification；It is recommended that eating method and amount: 3 times a day, 1 bag every time, warm boiled water；Shelf-life
24 months；Storage practice room temperature, ventilation, it is dry at.
Embodiment 12
A kind of pair of liver kidney has the health food of auxiliary protection function, and formula is same as Example 6, to make according to a conventional method
At packed medicinal tea.
Embodiment 13
A kind of pair of liver kidney has the health food of auxiliary protection function, and formula is same as Example 2, to make according to a conventional method
At capsule.
Embodiment 14
A kind of pair of liver kidney has the health food of auxiliary protection function, and formula is same as Example 3, and preparation method includes
Obtained active mixture is first made as described in Example 8；Tablet is made in conventional method again.
Embodiment 15
A kind of pair of liver kidney has the health food of auxiliary protection function, and formula is same as Example 4, and preparation method includes
Obtained active mixture is first made as described in Example 9；Capsule is made in conventional method again.
Embodiment 16
A kind of pair of liver kidney has the health food of auxiliary protection function, and formula is same as Example 5, and preparation method includes
Obtained active mixture is first made as described in Example 8；Tablet is made in conventional method again.
Comparative example 1
A kind of Chinese herbal granules, its raw material only includes 120 parts of ganoderma lucidum, 80 parts of Moringa, 15 parts of cassia seed in parts by weight；Its
Preparation method include first by ganoderma lucidum, Moringa, cassia seed as described in Example 10 be made clear cream (i.e. step 4) clear cream, it is relatively close
Degree is 1.30,30 DEG C)；100 parts of the clear cream is taken, 12.5 parts of maltodextrin, 55.5 parts of microcrystalline cellulose are added, is uniformly mixed, adds
Ethanol in proper amount solution softwood, the granulation of 16 meshes, 60 DEG C of dryings, 12 mesh sieves, that is, granule.
Comparative example 2
A kind of Chinese herbal granules, its raw material only includes 35 parts of Maca, 70 parts of Fructus Corni, cordyceps mycelia powder in parts by weight
20 parts, 15 parts of whey protein concentrate, 25 parts of soybean protein isolate；Preparation method includes that Maca, Fructus Corni are first pressed embodiment
Clear cream (i.e. step 4) clear cream, 1.30,30 DEG C of relative density) is made in 10 method；Again by formula be added cordyceps mycelia powder,
Active mixture is made in whey protein concentrate, soybean protein isolate；100 parts of active mixture are taken, maltodextrin 12.5 is added
Part, 55.5 parts of microcrystalline cellulose are uniformly mixed, and add ethanol in proper amount solution softwood, the granulation of 16 meshes, 60 DEG C of dryings, 12 meshes
Whole grain, that is, granule.
Comparative example 3
A kind of Chinese herbal granules, in parts by weight its raw material include 20 parts of cordyceps mycelia powder, 15 parts of whey protein concentrate,
25 parts of soybean protein isolate, 3 parts of xylo-oligosaccharide, 0.05 part of lycopene, 0.03 part of apple polyphenol.Preparation method includes first will
Cordyceps mycelia powder, whey protein concentrate, soybean protein isolate, xylo-oligosaccharide, lycopene, apple polyphenol are uniformly mixed, system
Obtain active mixture；100 parts of active mixture are taken, 12.5 parts of maltodextrin, 55.5 parts of microcrystalline cellulose are added, is uniformly mixed,
Add ethanol in proper amount solution softwood, the granulation of 16 meshes, 60 DEG C of dryings, 12 mesh sieves, that is, granule.
Experimental example 1 has auxiliary protection function zoopery to chemical damage
Experimental method: there is auxiliary guarantor to chemical lesion according in " health food is examined and assessment technique specification -2003 "
Experiment on Function method is protected, using alcoholic hepatic injury model scheme.Laboratory sample: health food granule prepared by embodiment 10,
Control sample: the Chinese herbal granules of comparative example 1-3 preparation.It is every for pressing human body to recommend dosage by laboratory sample and control sample respectively
3 times a day, each 20g is converted to 1g/kgBW by 60kg weight to people (adult).Separately set an alcoholic hepatic injury model group (mould
Type control group) and a negative control group.Every group of 12 animals (male white rat).
Experimental result:
1. influence of the sample to rat body weight: each group rat body weight is consistent before testing, the weight of each all rats of test process
And gain in weight when off-test is compared to each other, difference without conspicuousness (P > 0.05), shows the sample to the weight of rat
Increase satisfaction and significantly affects effect.
2. sample is to the shadow of hepatic tissue lipid peroxidation catabolite malonaldehyde (MDA) content of alcoholic liver injury in rats
Ring: the Liver MDA of liver injury model control rats is aobvious to be higher than negative control group, and the difference of the two is with extremely significant
Property (P < 0.01), illustrate liver injury model set up.The Liver MDA of control group (control sample 1-3, similarly hereinafter) rat is equal
Lower than liver injury model control group, but there are no significant (P > 0.05) for each group and the difference of liver injury model control group, shows this
The lipid peroxide content in liver tissues of rats that sample damages Alcoholic has certain reduction effect, but is not apparent.
The Liver MDA of experimental group (health food granule prepared by embodiment 10, similarly hereinafter) rat is substantially less than hepatic injury mould
It is aobvious to show that the lipid peroxide content in liver tissues of rats that the sample damages Alcoholic has for type control group (P < 0.05)
Write reduction effect.
Influence of 3 samples to hepatic tissue triglycerides (TG) content of alcoholic hepatic injury rat:
The hepatic tissue TG content of liver injury model control rats is apparently higher than negative control, and the difference of the two has extremely aobvious
Work property (P < 0.01), illustrates that hepatic injury is obviously set up.The hepatic tissue TG content of control group 1-3 rat is below liver injury model
Control group, but there are no significant (P > 0.05) for each group and the difference of liver injury model control group, shows that the sample damages Alcoholic
Lipid peroxide content in the liver tissues of rats of wound has certain reduction effect, but is not apparent.The liver of experimental group rat
Tissue T G content is substantially less than liver injury model control group, and difference all has extremely significant property (P < 0.01), illustrates that the sample has
Reduce the effect of hepatic tissue triglycerides (TG) content of the rat of Alcoholic damage.
The influence of hepatic tissue Reductive glutathione (GSH) content for the rat that 4 samples damage Alcoholic:
The hepatic tissue GSH content of liver injury model control rats is significantly lower than negative control group, and the difference of the two has pole
Conspicuousness (P < 0.01) shows that liver injury model is set up.The hepatic tissue GSH content of control group 1-3 rat is obviously higher than model
Control group, there are no significant for single difference (P > 0.05), shows that the GSH in liver tissues of rats that the sample damages Alcoholic contains
The measurer effect of improving, but be not apparent.The difference of experimental group and model control group all has extremely significant property (P <
0.01), show that the sample has the function of improving GSH content in the liver tissues of rats of alcoholic liver injury.
Influence of 5 samples to the hepatic tissue steatosis of alcoholic liver injury in rats: the liver of liver damage model control group rat
Tissue fat denaturation score value is significantly higher than negative control group, and the difference of the two has extremely significant property (P < 0.01), shows that liver damages
Model is set up.The hepatic tissue Steatosis score value of control group 1-3 rat is below liver injury model control group, but each group and liver
There are no significant for the difference of damage model control group (P > 0.05), shows in liver tissues of rats that the sample damages Alcoholic
Steatosis has certain mitigation effect, but is not apparent.The hepatic tissue Steatosis score value of experimental group rat is lower than liver
Model control group is damaged, and the difference of each dosage group and model control group all has extremely significant property (P < 0.01), shows that the sample has
Play the role of mitigating the liver tissues of rats steatosis of alcoholic liver injury.
6 brief summaries: health food granule prepared by the embodiment of the present invention 10 can reduce alcoholic liver injury rat model
Triglycerides (TG) content in hepatic tissue, improves Reductive glutathione (GSH) content in its hepatic tissue, mitigates its hepatic tissue
Steatosis degree, the weight of rat is had no significant effect.It can be seen that the sample, which has, has auxiliary to alcoholic liver injury
Defencive function.
2 toxicity test of experimental example
Laboratory sample: health food granule prepared by embodiment 10, recommending dosage by human body is everyone (adult) daily 3
Secondary, each 20g is converted to 1g/kgBW by 60kg weight.
Experimental method: safety is carried out according to " health food is examined and assessment technique specification " (version in 2003) pertinent regulations
Toxicological evaluation, as a result as follows:
1. acute toxicity test: showing to belong to non-poisonous material to the acute oral experiment of female, male mouse.
2. three genetic toxicity tests: three genetic toxicity tests (Salmonella reversion tests, mouse bone marrow polychromatic erythrocytes micronucleus
Test, mouse inbred strain) result is feminine gender.
During 3.30 days feeding trials, each dosage group rat body weight increases, food utilization is compared with the control group without significant
Sex differernce (P > 0.05).Female, male mouse blood biochemistry index, routine blood indexes and liver/body, spleen/body, kidney/body, male mouse testis/body ratio
There are no significant (P > 0.05) for difference compared with the control group.Liver,spleen,kidney, Stomach duodenum, the inspection of testis (ovary) histopathology
It looks into without obvious damage.
The experiment of 3 human experiment of experimental example
Select 31 age 45 years old~68 years old male alcohol hepatopaths, average age 55.3 years old, without other serious diseases.
Selection alcoholic liver patient criteria: patient has long-term, heavy drinking history, 40 ° daily 2 liang of white wine or more, lasts 3 years or more；
Loss of appetite, fatigue and weak, lean body mass；There is slight or moderate liver fibrosis；Serum glutamic oxalacetic transaminase significantly increases, and paddy third
Transaminase is normal, ratio between two 2: 1~5: 1.
Efficacy determination: effective: to stop excessive drinking；Symptom disappearance-appetite is good, and fatigue and weak disappears, with it energetically；It is thin
Improve, physical comfort；Liver fibrosis checks that 4 indexs are all qualified；Glutamic-oxalacetic transaminease is remarkably decreased, the ratio between with glutamic-pyruvic transaminase
< 2: 1.Effective: excessive drinking is reduced, and loss of appetite, fatigue and weak, lean body mass are alleviated；Grass Valley transaminase decline 10% with
On, but not up to effective standard.It is invalid: to continue to indulge in excessive drinking, symptom is unchanged.
When test-meal is tested, withdraw other medicines and nutrient and healthcare products, takes the health food of the preparation of the embodiment of the present invention 10
Granule, 3 times a day, each 20g, warm boiled water after meal；Observation 6 months are 1 period.Symptom has alleviation after 2 months,
After taking 6 months, symptom is relieved.In 31 people of clinical trial, effective 12 people, effective 15 people, invalid 4 people, total effective rate
87.1%.
The dosage form that granule is taken in this experimental example keeps drug administration simple and easy, effectively raises the absorption of drug
And utilize, in addition, what the present invention took is pure natural medical, any toxic additive and addictive drug are not added, it will not
Appetite-suppressing not will lead to diarrhea, have no toxic side effect, not habituation.It also found when experiment, the weight of most of experimental group subject
Mitigated, and blood lipid, blood pressure have different degrees of reduction, digestion has improvement, and mental attitude significantly improves, and prompts the present invention also
With health-care effects such as reducing blood lipid, blood pressure lowering and weight-reducing.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, fall within the scope of the claimed invention without departing from theon the basis of the spirit of the present invention.
Claims (9)
1. the health food that a kind of pair of liver kidney has auxiliary protection function, which is characterized in that its raw material includes ganoderma lucidum in parts by weight
10-200 parts, 10-150 parts of Moringa, 5-50 parts of cassia seed, Maca 10-150 parts, 10-200 parts of Fructus Corni, cordyceps mycelia powder 5-
50 parts, 5-50 parts of whey protein concentrate, 5-50 parts of soybean protein isolate, 0.0001-0.0005 parts of VA, VB1 0.0005-
0.005 part, VB20.0005-0.005 parts, VB60.0005-0.005 parts, 0.1-5 parts of xylo-oligosaccharide, lycopene 0.01-0.1
Part, 0.01-0.1 parts of apple polyphenol；
The health food is prepared by method comprising the following steps:
1) ingredient；
2) after mixing ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni, the 50%-90% alcohol reflux of 5-10 times of weight is added to mention
It takes 1-3 times, 0.5-3.0 hours each, filtration, filter residue is spare；Merging filtrate concentrates the filtrate to clear cream, and ethyl alcohol, which is added, to be made to contain
Alcohol amount reaches 70%-75%, obtains solution I；
3) water of 5-15 times of weight is added to decoct 1-3 times filter residue obtained by step 2), 0.5-2 hours each, collecting decoction, filtration,
Clear cream is concentrated the filtrate to, adds ethyl alcohol to make alcohol content up to 70%-75%, obtains solution II；
4) merge the solution I and solution II, stir evenly, stand, filtration, filtrate recycling ethanol is concentrated into clear cream；It is added by formula
Suitable dosage form is made in remaining raw material and appropriate amount of auxiliary materials.
2. health food according to claim 1, which is characterized in that its raw material includes ganoderma lucidum 50-150 in parts by weight
Part, 20-100 parts of Moringa, 10-40 parts of cassia seed, Maca 20-100 parts, 50-150 parts of Fructus Corni, cordyceps mycelia powder 10-40
Part, 10-40 parts of whey protein concentrate, 10-40 parts of soybean protein isolate, 0.0001-0.0005 parts of VA, VB1 0.001-0.005
Part, VB20.001-0.005 parts, VB60.001-0.005 parts, 1-5 parts of xylo-oligosaccharide, 0.02-0.08 parts of lycopene, apple
0.02-0.08 parts of polyphenol.
3. health food according to claim 1, which is characterized in that in parts by weight its raw material include 120 parts of ganoderma lucidum, it is peppery
Wooden 80 parts, 15 parts of cassia seed, 35 parts of Maca, 70 parts of Fructus Corni, 20 parts of cordyceps mycelia powder, 15 parts of whey protein concentrate, soybean
25 parts of protein isolate, 0.0003 part of VA, VB10.002 part, VB20.003 part, VB60.002 part, 3 parts of xylo-oligosaccharide, tomato
0.05 part of red pigment, 0.03 part of apple polyphenol.
4. health food according to claim 1-3, which is characterized in that its raw material or auxiliary material further include pharmaceutically
Or acceptable carrier on food or on health food.
5. health food according to claim 1-3, which is characterized in that the health food is formed into oral system
Agent；It include: capsule, granule, tablet, packed medicinal tea, pulvis.
6. health food according to claim 1-3, which is characterized in that its raw material of the health food or auxiliary material
It further include microcrystalline cellulose, magnesium stearate.
7. the preparation method of any one of the claim 1-6 health food, which comprises the following steps:
1) ingredient；
2) after mixing ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni, the 50%-90% alcohol reflux of 5-10 times of weight is added to mention
It takes 1-3 times, 0.5-3.0 hours each, filtration, filter residue is spare；Merging filtrate concentrates the filtrate to clear cream, and ethyl alcohol, which is added, to be made to contain
Alcohol amount reaches 70%-75%, obtains solution I；
3) water of 5-15 times of weight is added to decoct 1-3 times filter residue obtained by step 2), 0.5-2 hours each, collecting decoction, filtration,
Clear cream is concentrated the filtrate to, adds ethyl alcohol to make alcohol content up to 70%-75%, obtains solution II；
4) merge the solution I and solution II, stir evenly, stand, filtration, filtrate recycling ethanol is concentrated into clear cream；It is added by formula
Suitable dosage form is made in remaining raw material and appropriate amount of auxiliary materials.
8. the preparation method of health food according to claim 7, which is characterized in that appropriate microcrystalline cellulose is added in step 4)
Element, magnesium stearate, are made granule.
9. the preparation method of health food according to claim 7, which comprises the following steps:
1) ingredient；
2) will ganoderma lucidum, Moringa, cassia seed, Maca, Fructus Corni mix after, with 70%-75% alcohol reflux extract 2 times, the 1st time plus
Enter 8 times of w ethanols and extract 3h, 6 times of w ethanols of the 2nd addition extract 1h, filter, filter residue is spare；Merging filtrate, by filtrate
It is concentrated into clear cream, ethyl alcohol, which is added, makes alcohol content up to 70%-75%, obtains solution I；
3) filter residue obtained by step 2) is added water to cook 2 times, 10 times of weight waters of the 1st addition decoct 2h, 8 times of weight of the 2nd addition
Ethyl alcohol extracts 1h, collecting decoction, and filtration concentrates the filtrate to clear cream, adds ethyl alcohol to make alcohol content up to 70%-75%, obtains solution II；
4) merge the solution I and solution II, stir evenly, stand, filtration, filtrate recycling ethanol is concentrated into clear cream；It is added by formula
Remaining raw material is added and suitable dosage form is made in appropriate amount of auxiliary materials.
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| CN104547546A (en) * | 2014-12-26 | 2015-04-29 | 扬子江药业集团四川海蓉药业有限公司 | Traditional Chinese medicinal composition for reinforcing kidney and moistening lung and preparation method of traditional Chinese medicinal composition in different dosage forms |
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| CN102742840A (en) * | 2012-07-16 | 2012-10-24 | 西藏然康科技有限公司 | Maca Cordyceps buccal tablet and preparation method thereof |
| CN104547546A (en) * | 2014-12-26 | 2015-04-29 | 扬子江药业集团四川海蓉药业有限公司 | Traditional Chinese medicinal composition for reinforcing kidney and moistening lung and preparation method of traditional Chinese medicinal composition in different dosage forms |
| CN105146542A (en) * | 2015-10-25 | 2015-12-16 | 林爱玉 | Health-care food with antioxidant function and preparation method thereof |
| CN105267695A (en) * | 2015-11-17 | 2016-01-27 | 安徽千方生物科技有限公司 | Ganoderma lucidum spore powder compound product for improving anti-tumor curative effects and method for preparing ganoderma lucidum spore powder compound product |
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