CN105597026A - Traditional Chinese medicine decoction for treating cholestatic hepatitis - Google Patents

Abstract

The invention discloses traditional Chinese medicine decoction for treating cholestatic hepatitis. The traditional Chinese medicine decoction is prepared from, by weight, 25-25 parts of herba hyperici japonici, 25-35 parts of corn stigma, 15-25 parts of herba abri, 8-12 parts of radix curcumae, 8-12 parts of rhizoma curcumae longae, 8-12 parts of rhizoma curcumae, 8-12 parts of towel gourd vegetable sponge, 8-12 parts of rhizoma alismatis, 8-12 parts of rhizoma smilacis glabrae, 8-12 parts of fructus citri sarcodactylis, 4-6 parts of pericarpium citri reticulatae viride and 4-6 parts of licorice roots. According to the traditional Chinese medicine decoction for treating the cholestatic hepatitis, dialectical compatibility of the raw materials is achieved, the effects of removing dampness, removing jaundice, activating blood circulation to dissipate blood stasis, removing toxicity, promoting the circulation of qi, soothing the liver and relieving depression are achieved, and the treatment effect on the cholestatic hepatitis is significant.

Description

A kind of traditional Chinese herbal decoction for the treatment of cholestatic hepatitis

Technical field

The present invention relates to a kind of traditional Chinese herbal decoction for the treatment of cholestatic hepatitis.

Background technology

The similar acute icteric hepatitis of cholestatic hepatitis onset, but subjective symptoms is often lighter, and pruitus, defecates greyish white,Often have obvious liver enlargement, liver function test serum bilirubin obviously raises, taking bilirubin direct as main, and factor mobility> 60% or application vitamin K intramuscular injection after within one week, can rise to more than 60%, SBA, γ glutamyl transpeptidase, alkaline phosphataseEnzyme, cholesterol levels can obviously raise, and jaundice continues more than 3 weeks, and except the inside and outside obstructive jaundice of the liver that causes of other reasonPerson, diagnosable is acute viral cholestatic hepatitis, and above-mentioned clinical manifestation person occurs on chronic hepatitis basis, diagnosable is chronic silt courageType hepatitis. Cholestatic hepatitis surely belongs to motherland's medical science " jaundice " category.

Jaundice is with order Huang, body Huang, and urine Huang is a kind of disease of primary symptom, wherein the particularly important spy of this disease of order eyeball xanthochromiaLevy. Jaundice is moved back as suitable with speed, as " Synopsis Golden Chamber jaundice abnormal pulse is demonstrate,proved and controlled " points out: " disease of jaundice, when with 18 days schedule to last,Within ten days that control, be recovered above, anti-acute person is refractory. If " obstinate disease, stagnation of QI-blood, injures liver spleen, have that the disease of leading to is long-pending, bulging itMay. Doctor trained in Western medicine is introduced the harm of jaundice: the function of (one) infringement liver: because hepatitis viruse is invaded liver, and in liver cellConstantly copy. Under the immune response effect of body, damage together liver cell, make liver cell oedema, destruction that liver organization is sent outRaw inflammatory is invaded profit, hyperemia, oedema, ooze out, a series of variations such as degeneration of liver cells and necrosis. Just so just affect hepatic tissueNormal state and structure, damaged the various functions of the bilirubin metabolism of liver. Liver is impaired for a long time, and proliferation of fibrous tissue can be drilledBecome cirrhosis, even develop into liver cancer. (2) threat to life: produce the material of jaundice bilirubin, it has two kinds of forms:It is fat-soluble planting, and another kind is water miscible. Though the toxicity of water soluble bilirubin is little, but can cause that this bilirubin raisesDisease in the liver and gallbladder the harmfulness of human body is exceeded to the toxicity of itself. Fat-soluble bilirubin can be calm to nuclei of cranial nerves, moreLong-pending more, the function affecting the nerves, can cause very harmful nuclear icterus. Nuclear icterus the lighter can affect people's brain, and severe one is worked asTime will threat to life.

Therefore clinical treatment cholestatic hepatitis, needs rapid removing jaundice, very urgent. Therefore find a kind of effectively treatment silt courage type liverScorching method is significant.

Summary of the invention

Based on above-mentioned technical problem, the invention provides a kind of traditional Chinese herbal decoction for the treatment of cholestatic hepatitis.

The technology used in the present invention solution is:

Treat a traditional Chinese herbal decoction for cholestatic hepatitis, it is to be made by the Chinese medicine material of following weight portion proportioning: 25～35 parts of hypericum japonicum, 25～35 parts of corn stigmas, 15～25 parts of Canton love-pea vines, 8～12 parts of root tubers of aromatic turmeric, 8～12 parts, turmeric, curcuma zedoary 8～12 parts, 8～12 parts of luffas, 8～12 parts of rhizoma alismatis, 8～12 parts of smilaxs, 8～12 parts of Buddha's hands, 4～6 parts, rascal, Radix Glycyrrhizae 4～6 parts.

Preferably, the weight portion proportioning of each Chinese medicine material is 30 parts of hypericum japonicum, 30 parts of corn stigmas, 20 parts of Canton love-pea vines, root tuber of aromatic turmeric10 parts, 10 parts, turmeric, 10 parts of curcuma zedoarys, 10 parts of luffas, 10 parts of rhizoma alismatis, 10 parts of smilaxs, 10 parts of Buddha's hands, 5 parts, rascal, Radix Glycyrrhizae 5Part.

Pharmacology of the present invention and beneficial effect are as follows:

Applicant is by clinical observation, in conjunction with the cholestatic hepatitis cause of disease of causing a disease, think that this sick interpretation of the cause, onset and process of an illness mainly blames in wet," Synopsis Golden Chamber jaundice abnormal pulse is demonstrate,proved and controlled " section is pointed out: " yellow family gained, caused by pathogenic dampness ". In damp evil, accumulate, retardance mechanism of qi, gas is capableFreely, in hemostasis, stop, " facing card guide " points out: " the not all right jaundice of qi and blood ". Damp evil and hemostasis are tied mutually, cause bile Bu Xunchang road, outerOverflow skin, on note in order, body Huang, order Huang, bet and urinate Huang in bladder.

In side, hypericum japonicum, corn stigma are that monarch drug in a prescription is with dampness removing removing jaundice, promoting blood circulation to remove blood stasis altogether. Canton love-pea vine, root tuber of aromatic turmeric, turmeric, curcuma zedoary, silkMelon network, rhizoma alismatis be ministerial drug with blood-activating and qi-promoting, eliminating damp, detoxifying; Smilax, Buddha's hand, rascal are adjutant, are aided with clearing damp promoting the circulation of qi, soothing the liver solutionStrongly fragrant; Radix Glycyrrhizae is for making medicine with coordinating the drug actions of a prescription. Full side's compatibility, plays dampness removing removing jaundice altogether, promoting blood circulation to remove blood stasis, removing toxic substances promoting the circulation of qi, the merit of soothing liver-qi stagnationEffect is remarkable to cholestatic hepatitis result for the treatment of.

In the other side, selected each Chinese medicine material is elaborated below:

Hypericum japonicum bitter, flat. Return liver, gallbladder channel. Effect dampness removing removing jaundice, clearing heat and detoxicating, activating blood circulation and reducing swelling. " the sward property of medicine is standbyWant ": " control wine disease, subside a swelling swollen, apply the large sore of disliking, reason infantile malnutrition due to digestive disturbances or intestinalparasites sore is swollen. " " interrogating book on Chinese herbal medicine ": " be coated with fire poison, positive crux subcutaneous ulcer disappears. " " classification grassThe property of medicine ": " separate all snakeworm poison, relieve inflammation or internal heat, stopping leak rushes down, and knife wound is with good. " " south of the Five Ridges gather medicinal herbs record ": " remove the yellow fire poison of nitre, apply shrimp pincers sore,Reason fall beat, snakebite. "

Corn stigma taste is sweet, light, and property is flat, returns bladder, liver, gallbladder channel. Effect inducing diuresis for removing edema, dampness removing removing jaundice. " the southern regions of the Yunnan Province book on Chinese herbal medicine ":" gas under wide intestines. Control married woman's breast knot, alactation, congestion and swelling pain, the heating of being afraid of cold, headache body is tired. " " south of the Five Ridges gather medicinal herbs record ": " and pigMeat is decocted soup and is controlled diabetes, controls again dribbling urination sandstone, if unbearably painful, decoct soup and is taken in small doses at short intervals. " " modern Practical Chinese medicinal ": " be diuresisMedicine, to kidney trouble, edema illness, diabetes etc. are effective. It is again the active drug of cholecystitis, cholelith, hepatitis jaundice etc. " " the peopleBetween conventional glossary of Herbs and Drugs ": " can reduce blood pressure, inducing diuresis to reduce edema. Control nosebleed, red collapsing. " " national Chinese herbal medicine compilation ": " inducing diuresis to reduce edema,Flat liver cholagogic. Treating acute and chronic nephritis, oedema, acute, chronic hepatitis, hypertension, diabetes, chronic paranasal rhinitis, lithangiuria, courageCalculus, and prevent habitual abortion. "

Canton love-pea vine taste is sweet cool, returns liver, stomach warp. Effect clearing heat and promoting diuresis, blood stasis removing analgesic. Main icteric hepatitis, stomachache, rheumatic boneBitterly, fall and beat stasis of blood pain, breast pain. " south of the Five Ridges herbal ": " hot and suffocating clearly, the liver of relaxing, and spleen, continuous injured. " " conventional Chinese medicine handbook " say this product:" clearing heat and promoting diuresis, Shugan Zhitong. Treating acute and chronic hepatitis, cirrhotic ascites ... ". " book on Chinese herbal medicine pushes away old " said " to be had antipyretic diuresis, invigorates blood circulationAnalgesic effect. "

Root tuber of aromatic turmeric taste is pungent, bitter, cold in nature, returns liver, the heart, lung channel. Effect regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice, invigorate blood circulation onlyPromoting qi circulation and removing obstruction in the collateral bitterly,, cool blood clears away heart-fire. " property of medicine opinion ": " control woman place vim and vigour pained, cold air knot is poly-, and warm vinegar rubs and takes it. " " Tang originallyGrass ": " main blood is long-pending, lower gas, and myogenic, hemostasis, broken extravesated blood, blood drenches, hematuria, metal-inflicted wound. " " Amplification on Materia Medica addendum ": " controlling strongly fragrant holding back can notLoose. " " book on Chinese herbal medicine is just ": " antiemetic blood, bleeding from five sense organs or subcutaneous tissue; Alone married woman's cold air blood of controlling amasss, and knot gather qi together is stagnant, and trusted subordinate has a pain. " " book on Chinese herbal medicine is stated ": " controlHeating, strongly fragrant, cough, bleeding from the gum, cough blood, haematuria, has a headache dizzy, mad epilepsy, stagnant under, drench, and the card such as eyes nose glossopharyngeum larynx. " " book on Chinese herbal medicineStandby wanting ": " promoting the circulation of qi, Xie Yu; Let out blood, the broken stasis of blood. Cool heart heat, loose liver depression. "

Turmeric taste is arduous, and temperature, returns spleen, Liver Channel. Effect is broken blood gas, inducing meastruation to relieve menalgia. Tang Materia Medica: " main trusted subordinate ties long-pending, ZhuDisobedient, lower gas, broken blood, except wind-heat, subduing inflammation. Power is strong in root tuber of aromatic turmeric. " " Japan hanako materia medica ": " control abdominal mass clot, carbuncle is swollen, logical monthWarp, controls to fall and flutters hemostasis, detumescence poison; Only storm wind pain cold air, lower food. " " Bencao Tujing ": " and control inflatable and postpartum sepsis make a psychological attack. " " guiding principleOrder ": " control wandering arthritis brachialgia. " " book on Chinese herbal medicine is just ": " and except the depressed inflatable of trusted subordinate, cold air dyspepsia pain. " " book on Chinese herbal medicine is stated ": " control gas card ruffian card,Turgor is breathed heavily and is choked, epigastric pain, the abdomen side of body shoulder back of the body and brachialgia, numbness, hernia. " " medical center bun is wanted ": " control the wind-cold-dampness arthralgia of four limbs. "

Curcuma zedoary taste is pungent, bitter, warm in nature, enters liver, the spleen channel. Blood is broken in effect promoting the circulation of qi, long-pending pain relieving disappears. " Japan hanako materia medica ": " control allGas. Appetizing, helps digestion, logical menstruation, and the hemostasis that disappears, only flutters and damages the lower blood of pain, and interior damage extravesated blood etc. ". " herbal classic is met former ": " zedoary enters liverBroken blood, controls married woman's vim and vigour knot long-pending, and phlegm addiction cold air falls to flutter and damages pain, lower blood, and interior damage extravesated blood, and the poly-blood of logical Liver Channel, covers the special relieving stagnant Qi of this medicineIn blood also ". " book on Chinese herbal medicine is newly organized ": " blood system Chinese medicine also. The specially blood in relieving stagnant Qi, Xuan addiction can be gone, only distressed, logical menstruation, the hemostasis that disappears,Control cholera, rush down and gather, gas in reason. Specially enter that gas divides to break blood, though broken blood is not so felt frustrated yet ".

The sweet property of luffa taste is flat, enters lung, stomach, Liver Channel. There is clearing and activating the channels and collaterals, clearing heat and eliminating phlegm effect. " book on Chinese herbal medicine is new again " recorded:" network that stimulates the menstrual flow, and blood vessels reduce phlegm pleasant ".

Rhizoma alismatis taste is sweet, light, cold, returns kidney, urinary bladder channel. Effect clearing damp and promoting diuresis, clearing heat-fire. " herbal classic ": " main wind-cold-dampness arthralgia,Breast is difficult, and the water that disappears is supported the five internal organs, and beneficial strength is fertile strong. " " not Lu ": " qi-restoratives damages the exhaustion or lesion of the five internal organs, full except the five internal organs ruffian, plays cloudy gas, stopping leak essence, disappearsYearningly, drench drop, cut off the water by bladder, three warmers. " " property of medicine opinion ": " the main essence of suffering from a deficiency of the kidney, from going out, is controlled five pouring, sharp bladder heat, straight through water passage. " " dayChina's son book on Chinese herbal medicine ": " control general debility, main head revolves, the empty ring of ear, muscles and bones contracture, and logical small intestine, only loses drop, hematuria. " " medicine origin ":" control dribbling urination, remove nether world sweat. " curing mainly secret formula " cloud, removes old water, supports new water, diuresis, and consumer edema, oozes to let out and quenches the thirst. " " guiding principleOrder ": " dysentery, colic, beriberi are told, rushed down to preventing or arresting vomiting for excreting dampness heat, row phlegm and retained fluid. "

Smilax taste is sweet, light, flat, returns liver, stomach warp. Effect eliminating damp, detoxifying, strengthening the spleen and stomach, protects liver, easing joint movement. " book on Chinese herbal medicineNew again " also call its " clearing damp heat, relieving rigidity of muscles and joints. " Compendium of Material Medica: " smilax, has red white two kinds, enters medicinal Bai Zheliang. By " middle mountainThrough " cloud, here the mountain of drum stirrup has grass, name is said flourish grass, its leaf is as willow, it is as ovum gallinaceum, the wind of food, be probably this also ... smilaxCan strengthening the spleen and stomach, curing rheumatism, the strong battalion of taste defend from, rheumatism is gone muscles and bones profit. " " book on Chinese herbal medicine justice ": " smilax, dampness removing reduces phlegm and internal heat, energyEnter network, search and pick the damp and hot poison that accumulates. It separates mercury, calomel mercurous chloride poison person, and it is up that carries receipts poison with liter, and this leads as business to ooze under profit, thereforeSpecially control red bayberry carbuncle, go deep into hundred networks, arthralgia, even rotten, poison fire is up again, and sore-throat is burst, and all dislike disease. " " book on Chinese herbal medicine picks upLose ": " careless aetite, root joins together as small cup, and half on soil, and skin is as Poria cocos, the red puckery of meat, people gets Yi Danggu, not hungry ... adjust and endLet out. "

Buddha's hand taste is pungent, bitter, sweet, warm, returns liver, spleen, stomach three warps. Effect regulating qi-flowing for eliminating phlegm, preventing or arresting vomiting dissipate-swelling, liver soothing and speen fortifying, dispel the windHeat-clearing. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " tonifying liver warms up stomach, and preventing or arresting vomiting is told, and the stomach cold that disappears phlegm, controls stomach Qi pain, the only cold pain of face, and middle promoting the circulation of qi. " " guiding principleOrder ": " boil beverage, control mental disorder cough. Decoct soup, control gas pain under the heart. " " herbal classic is met former ": " specially broken stagnant gas. Heavy after controlling under dysentery. " " thisGrass is new again ": " control the gas liver of relaxing, and stomach reduces phlegm, broken long-pending. Control dysphagia and regurgitation, the lump in the abdomen that disappears lump in the abdomen, scrofula. " " book on Chinese herbal medicine is new again ": " control the easypro liver of gas,Reduce phlegm with stomach, broken long-pending, control dysphagia and regurgitation, eliminating mass lump in the abdomen scrofula. "

Rascal toil, tepor, returns liver, gallbladder channel. Effect is soothing the liver relieving stagnant Qi, long-pendingization that disappear is stagnant. " Bencao Tujing ": " the main stagnation of the circulation of vital energy, underFood, broken long-pending knot and diaphragm gas. " " " curing mainly secret formula " cloud; " dividing of the moon of fainting, few sun illly used it. Broken hard addiction, loose stagnant gas, goes the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels allWet, left flank has pneumatosis. " " detailed outline ": " and control the chest diaphragm circulation of vital energy in the wrong direction, hypochondriac pain, underbelly hernia, the breast that disappears is swollen, soothing the liver courage, purging the lung of pathogenic fire gas. " " book on Chinese herbal medicine is standbyWant ": " the eliminating phlegm ruffian that disappears, controls stagnation of liver qi, the many anger of hypochondriac pain, and chronic malaria knot addiction, colic, breast is swollen. "

Radix Glycyrrhizae is sweet, flat, the thoughts of returning home, lung, spleen, stomach warp. Effect is invigorated the spleen and benefited qi, clearing heat and detoxicating, relieving spasm to stop pain, coordinating the drug actions of a prescription. " thisThe grass adopted addendum of spreading out ": " Radix Glycyrrhizae taste is sweet, slow greatly all fire. Part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels medicine use less, probably large slow can not going directly ". " explaining abstruseness of the canon of materia medica ": " Radix Glycyrrhizae, sweetFlat product, solely enter taste, and Li Shizhen (1518-1593 A.D.) is said and can be passed into 12 through person, also non-. Sowing and reaping is done sweet, and the positive taste of soil is mended therefore Radix Glycyrrhizae is Middle PalaceAgent ". " book on Chinese herbal medicine is just ": " Radix Glycyrrhizae, taste to sweet, obtains the property of neutralization, has the merit of adjusting benefits, therefore its poison of the solution that poison obtains, firm medicine obtain sum itsProperty, what medicine administered to bring out the cold obtained helps outside it, put in poison slow its speed. Eliminating evil heat, hard muscles and bones, strengthening the spleen and stomach, longue meat. Enter gas with gas medicine, with bloodMedicine enters blood, without toward can not, therefore claim state old ". " medicine justice ": " Radix Glycyrrhizae, raw with cool and purging intense heat, main loose table heresy, subduing inflammation, relieve sore throatBitterly, separate hundred medicine poison, except stomach accumulated heat, go urinary catheter pain, the power of this sweet cool heat extraction also. Process the bowl spares by temperature, main insufficiency of the spleen cunning is rushed down, empty mouthful of stomachYearningly, fever and chills coughs, breathes hard sleepy, and forced labour is deficient, and the merit that this sweet temperature helps spleen also. "

Side's medicine modern pharmacological research is as follows:

The many-sides such as the selected medicine of we proves mostly to have through modern pharmacological research and good protects the liver, cholagogic, anti-inflammatory, encircle moreThe effect of joint.

Hypericum japonicum low concentration liquid extract has excitation to intestinal tube, and high concentration is spasm and shrinks. Protect the liver, anticancer, antimalarial,Antibacterial action.

Corn stigma has remarkable increase choleresis and promotes the effect of bile excretion, can make the interior organic matter of bile and slag subtractFew, viscosity, proportion and content of bilirubin reduce.

Canton love-pea vine is mainly containing active chemicals such as yearning between lovers alkali, choline, and the thick saponin of Canton love-pea vine is to carbon tetrachloride (CCl4) instituteCause hepatic injury and have remarkable protection effect.

Root tuber of aromatic turmeric has hepatoprotective effect, can be by induction liver microsomes cytochrome P-450, improve liver to the hepatotoxicant that becomesBio-transformation technical ability, strengthens the detoxication of liver, promotes hepatocellular injury reparation; There is choleretic effect, to gall-bladder and 12 fingersIntestines longitudinal muscle has excitation, can strengthen it and shrink, and has invigorating gallbladder and removing gall-stone effect.

Turmeric has choleretic effect, and Curcuma and preserved material can increase the choleresis of dog, makes bile component recover normal, andIncrease gallbladder contraction, its effect is weak and lasting, sustainable 1～2 hour. Curcumin or its sodium salt have choleretic effect, intravenous injectionIn dog, can reduce the content of solid constituent and increase choleresis, but from total absolute value, cholate, bilirubin, courage steroidAlcohol secretory volume all increases, and it is constant that fatty acid composition keeps. The volatile oil proposing in another kind of congener increases choleresis, lookElement causes gallbladder contraction. Curcumen is cholesterine solvent, can be in order to treat Biliary Calculi.

Curcuma zedoary has certain anti-thrombosis function. Curcuma Aromatic Oil has the effect of killing cancer cell; Rcumenol have press downKnurl effect; Oil of zedoary turmeric can strengthen host specificity immunity by immune system and obtain obvious immunoprotective effec; SimultaneouslyAlso has Radiosensitizing tumor-inhibiting action.

The contained oleanolic acid of luffa has therapeutic action to the acute liver damage being caused by carbon tetrachloride, can alleviate liver cellStarch hollow sex change, loose sex change, necrosis of liver cells and leaflet reaction of degeneration (RD).

The fatty contents of rhizoma alismatis has obvious norcholesterol effect and anti-artery congee to experimental hypercholesterolemicrabbits rabbitSample induration. Clinical practice also finds, rhizoma alismatis, in the time reducing serum total cholesterol, also reduces triglycerides, improves highThe content of density lipoprotein and the ratio of HDL-C/T-CHOL. This is to preventing and treating atherosclerotic undoubtedlyFavourable. Rhizoma alismatis can make to raise content fatty in the rabbit liver of and high fat admittedly liquor-saturated with courage and reduce, and showing has lipotropy.

Rat experiment liver damage tool protective effect due to smilax water decoction is poisoning to TAA, alcohol extract acts onNot obvious, the active component of the hepatoprotective effect of prompting smilax has certain hydrophily. Smilax has necessarily prevent liver cancerPractical value.

Pain when Buddha's hand can alleviate digestion, indigestion, flatulence, angina, poor appetite, can drive away intestinal parasite,And obviously eliminate gall stone, promote appetite.

Rascal, containing volatile oil energy stimulating gastrointestinal road, promotes digestive juice secretion and gastrointestinal pneumatosis to get rid of, and has digestion promoting function. Can be aobviousWork increases BF output, and diastole smooth muscle of bile vesica, has choleretic effect.

Radix Glycyrrhizae has obvious antiinflammatory action, and liver is had to significant protective effect, also has lipotropism matter oxidation; GlycyrrhizinElement has activation to reticuloendothelial system, and the Radix Glycyrrhizae ammonium of variable concentrations all has significant increasing to mouse natural killer cell activityBy force; Radix Glycyrrhizae also can strengthen specific immune function; Radix Glycyrrhizae has antitumor action; Radix Glycyrrhizae all has in square medicine combination, formula, immunityDual regulation.

1. clinical data

Adopt experimental technique random, contrast according to " new Chinese medicine guideline of clinical investigations ", choose 2011.01-2013.07 in the hospital of traditional Chinese hospital's hospitalization of Huangdao District, Qingdao City, meets internal medicine branch of China Association of Traditional Chinese Medicine in YichangThe patient of the inclusive criteria of " virus hepatitis Standards of Chinese Medical Syndrome Differentiation " cholestatic hepatitis of revision, the side of employing table of random numberMethod, divides two groups by 40 routine study subjects, wherein male 29 examples, female's 11 examples; 18～68 years old age, average 38 years old; The course of disease 16 days～51My god. There are hepatitis B medical history 36 examples, hepatitis A 3 examples, viral hepatitis type E 1 example. 40 routine patients are divided into 2 groups for the treatment of group, control groups at random, every group each 20Example, from sex, age, course of disease comparison, difference not statistically significant (P > 0.05), data has comparativity.

2. methods for the treatment of

Control group: diammonium glycyrrhizinate injection 150mg, quiet, day is once; " kuhuang " injection 40ml, quiet, day once. Within 4 weeks, be1 course for the treatment of.

Treatment group: diammonium glycyrrhizinate injection 150mg, quiet, day is once; 1 dose of traditional Chinese herbal decoction of the present invention every day, be decocted in water for oral dose, early2 sub-services in evening 4 weeks are 1 course for the treatment of.

3. observation index

1. itch, the clinical symptoms such as weak are improved situation. 2. liver function total bilirubin (TBiL), bilirubin direct(DBiL), alanine aminotransferase (ALT), alkaline phosphatase (ALP), TBA (TBA) improvement situation.

4. curative effect determinate standard

People's Republic of China's traditional Chinese medicine professional standard of issuing with reference to State Administration of Traditional Chinese Medicine " treat by the diagnosis of traditional Chinese medical science diseaseCriterion standard ": 1. cure: jaundice disappears, other transference cures, lab index is normal; 2. take a turn for the better: jaundice and other symptoms subtractGently, bilirubin is normal or reduce other lab index improvements; 3. do not heal: jaundice is not moved back or deepened, other symptoms and laboratoryIndex is without improvement.

5. statistical method

Application SPSS13.0 version statistical software analyzes. Result is with mean ± standard deviation (x ± s) represent. Measurement dataWith t inspection, rate relatively use χ²Inspection, ranked data adopt Ridit to analyze.

6. result

The Comprehensive Clinical curative effect comparison of 6.1 liang of groups, in table 1.

Table 1

(4 weeks) changes of biochemical indexes situation statistical comparison after finishing for 6.2 courses for the treatment ofIn table 2.

Table 2

Epidemiological Analysis by statistics, treatment group and control group comparing difference have conspicuousness (P < 0.05), and treatment group is better than control group.

7. bad reaction

We to the blood analysis before and after study subject treatment, urinalysis, stool routine examination, liver, renal function, electrocardiogram,The safety indexes such as Abdominal B type ultrasonography are all observed, and all patients of result are good to this treatment tolerance, do not find bright during treatmentAobvious bad reaction, medicine to each system all without recent toxicity damage.

8. follow up a case by regular visits to

Two groups of patients all complete the observation of curative effect in March smoothly, and all patients all do not occur serious adverse reaction and should not continueThe special physiological that continued access is put to the test changes.

Detailed description of the invention

Embodiment 1

Take each Chinese medicine material by following weight parts proportioning:

30 parts of hypericum japonicum, 30 parts of corn stigmas, 20 parts of Canton love-pea vines, 10 parts of root tubers of aromatic turmeric, 10 parts, turmeric, 10 parts of curcuma zedoarys, luffa 10Part, 10 parts of rhizoma alismatis, 10 parts of smilaxs, 10 parts of Buddha's hands, 5 parts, rascal, 5 parts, Radix Glycyrrhizae.

Preparation method is as follows:

The Chinese medicine material of load weighted above-mentioned weight portion is put into drug-decocting appliance, add clean water, amount of water is to exceedLiquid level 2～3cm is advisable; Enter to decoct and front above-mentioned Chinese medicine material is soaked to half an hour, make it fully moistening, fully fried in order to concoction;Then (suddenly) fire of useing force boils, then uses literary composition (micro-) fire instead and decoct. Stop when decocting about 15-30 minute, remove the dregs of a decoction, get decoction.

Embodiment 2

Take each Chinese medicine material by following weight parts proportioning:

25 parts of hypericum japonicum, 35 parts of corn stigmas, 15 parts of Canton love-pea vines, 12 parts of root tubers of aromatic turmeric, 8 parts, turmeric, 8 parts of curcuma zedoarys, 8 parts of luffas,12 parts of rhizoma alismatis, 12 parts of smilaxs, 12 parts of Buddha's hands, 6 parts, rascal, 4 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 1.

Embodiment 3

Take each Chinese medicine material by following weight parts proportioning:

35 parts of hypericum japonicum, 25 parts of corn stigmas, 25 parts of Canton love-pea vines, 8 parts of root tubers of aromatic turmeric, 12 parts, turmeric, 12 parts of curcuma zedoarys, luffa 12Part, 8 parts of rhizoma alismatis, 8 parts of smilaxs, 8 parts of Buddha's hands, 4 parts, rascal, 6 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 1.

Claims (2)

1. treat a traditional Chinese herbal decoction for cholestatic hepatitis, it is characterized in that it is the Chinese medicine material system by following weight portion proportioningWork forms: 25～35 parts of hypericum japonicum, 25～35 parts of corn stigmas, 15～25 parts of Canton love-pea vines, 8～12 parts of root tubers of aromatic turmeric, turmeric 8～12Part, 8～12 parts of curcuma zedoarys, 8～12 parts of luffas, 8～12 parts of rhizoma alismatis, 8～12 parts of smilaxs, 8～12 parts of Buddha's hands, rascal 4～64～6 parts, part, Radix Glycyrrhizae.

2. a kind of traditional Chinese herbal decoction for the treatment of cholestatic hepatitis according to claim 1, is characterized in that each Chinese medicine materialWeight portion proportioning is: 30 parts of hypericum japonicum, 30 parts of corn stigmas, 20 parts of Canton love-pea vines, 10 parts of root tubers of aromatic turmeric, 10 parts, turmeric, 10 parts of curcuma zedoarys, sponge gourd10 parts of networks, 10 parts of rhizoma alismatis, 10 parts of smilaxs, 10 parts of Buddha's hands, 5 parts, rascal, 5 parts, Radix Glycyrrhizae.