CN105581331B - A kind of nutritional composition for calcium supplement - Google Patents
A kind of nutritional composition for calcium supplement Download PDFInfo
- Publication number
- CN105581331B CN105581331B CN201511014069.0A CN201511014069A CN105581331B CN 105581331 B CN105581331 B CN 105581331B CN 201511014069 A CN201511014069 A CN 201511014069A CN 105581331 B CN105581331 B CN 105581331B
- Authority
- CN
- China
- Prior art keywords
- calcium
- nutritional composition
- supplement
- calcium supplement
- oligosaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 82
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 75
- 229940069978 calcium supplement Drugs 0.000 title claims abstract description 73
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 125
- 239000011575 calcium Substances 0.000 claims abstract description 125
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 125
- 241001122767 Theaceae Species 0.000 claims abstract description 51
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 33
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 33
- 230000002485 urinary effect Effects 0.000 claims abstract description 19
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 18
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 13
- 239000011707 mineral Substances 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 230000009467 reduction Effects 0.000 claims description 5
- 235000000346 sugar Nutrition 0.000 claims description 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 4
- 229930003316 Vitamin D Natural products 0.000 claims description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 4
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 4
- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 4
- 235000019166 vitamin D Nutrition 0.000 claims description 4
- 239000011710 vitamin D Substances 0.000 claims description 4
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 4
- 229940046008 vitamin d Drugs 0.000 claims description 4
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims description 3
- 239000003623 enhancer Substances 0.000 claims description 3
- 230000007413 intestinal health Effects 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- -1 sugar Alcohol compound Chemical class 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims description 2
- 125000000647 trehalose group Chemical group 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 abstract description 7
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 34
- 241000700159 Rattus Species 0.000 description 34
- 230000000052 comparative effect Effects 0.000 description 23
- 239000008280 blood Substances 0.000 description 20
- 210000004369 blood Anatomy 0.000 description 20
- 230000037182 bone density Effects 0.000 description 19
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 18
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
- 239000005913 Maltodextrin Substances 0.000 description 15
- 229920002774 Maltodextrin Polymers 0.000 description 15
- 229940035034 maltodextrin Drugs 0.000 description 15
- 238000001035 drying Methods 0.000 description 14
- 238000005469 granulation Methods 0.000 description 14
- 230000003179 granulation Effects 0.000 description 14
- 235000013336 milk Nutrition 0.000 description 14
- 239000008267 milk Substances 0.000 description 14
- 210000004080 milk Anatomy 0.000 description 14
- 238000002156 mixing Methods 0.000 description 14
- 239000000843 powder Substances 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 13
- 239000008103 glucose Substances 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 12
- 230000036772 blood pressure Effects 0.000 description 12
- 238000002425 crystallisation Methods 0.000 description 11
- 230000008025 crystallization Effects 0.000 description 11
- 235000010755 mineral Nutrition 0.000 description 11
- 235000006408 oxalic acid Nutrition 0.000 description 11
- 210000002700 urine Anatomy 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 235000019359 magnesium stearate Nutrition 0.000 description 9
- 239000007910 chewable tablet Substances 0.000 description 8
- 239000000845 maltitol Substances 0.000 description 8
- 235000010449 maltitol Nutrition 0.000 description 8
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 8
- 229940035436 maltitol Drugs 0.000 description 8
- QLOKJRIVRGCVIM-UHFFFAOYSA-N 1-[(4-methylsulfanylphenyl)methyl]piperazine Chemical compound C1=CC(SC)=CC=C1CN1CCNCC1 QLOKJRIVRGCVIM-UHFFFAOYSA-N 0.000 description 7
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- 210000002436 femur neck Anatomy 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 238000007912 intraperitoneal administration Methods 0.000 description 7
- 210000003734 kidney Anatomy 0.000 description 7
- 230000002503 metabolic effect Effects 0.000 description 7
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 7
- 238000004321 preservation Methods 0.000 description 7
- 235000020183 skimmed milk Nutrition 0.000 description 7
- 238000002798 spectrophotometry method Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- 235000019634 flavors Nutrition 0.000 description 6
- 230000037406 food intake Effects 0.000 description 6
- 238000012856 packing Methods 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 5
- 239000000905 isomalt Substances 0.000 description 5
- 235000010439 isomalt Nutrition 0.000 description 5
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 3
- 230000003185 calcium uptake Effects 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 150000005846 sugar alcohols Chemical class 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 210000005239 tubule Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000186000 Bifidobacterium Species 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- 208000001132 Osteoporosis Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- 150000002632 lipids Chemical class 0.000 description 2
- 235000021590 normal diet Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- PFRQBZFETXBLTP-RCIYGOBDSA-N 2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-RCIYGOBDSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- 241000040710 Chela Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- YTBSYETUWUMLBZ-QWWZWVQMSA-N D-threose Chemical compound OC[C@@H](O)[C@H](O)C=O YTBSYETUWUMLBZ-QWWZWVQMSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 108010001441 Phosphopeptides Proteins 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
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- 150000001450 anions Chemical class 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- MWKXCSMICWVRGW-UHFFFAOYSA-N calcium;phosphane Chemical compound P.[Ca] MWKXCSMICWVRGW-UHFFFAOYSA-N 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
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- 235000012000 cholesterol Nutrition 0.000 description 1
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- 238000000576 coating method Methods 0.000 description 1
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- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 239000000945 filler Substances 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
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- 230000000050 nutritive effect Effects 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 235000008939 whole milk Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention provides a kind of nutritional composition for calcium supplement, which includes calcium, oligosaccharide and smears tea.Compared with existing nutritional composition for calcium supplement, the present invention is remarkably improved the absorptivity and bioavailability of calcium, and the problem of can prevent or reduce by constipation caused by replenishing the calcium and calculi in urinary system, is especially suitable for person in middle and old age or has the three high crowds that replenish the calcium edible.
Description
Technical field
The invention belongs to functional food, technical field of health care food, specifically a kind of nutritional composition for calcium supplement.
Background technology
Calcium is the macroelement in human nutrition element, occupies the first place of nutrient.It promote skeleton development and
It maintains all to play a crucial role on the normal function of heart.And mid-aged population calcium absorptivity is inherently relatively low, calcium current
It loses more, and can be also easier to while calcium deficiency with symptoms such as hypertension, hyperlipidemia, hyperglycemia, thus safety is replenished the calcium to it
It is more important.
There are many product replenished the calcium on the market at present, but mostly single calcium or calcium and the trace element production that such as dimension D, CPP are combined
Product.During absorption of human body calcium, since positively charged calcium ion and negatively charged anion all cannot be thin through small intestine
After birth, and it is combined into corresponding slightly solubility calcium salt with phytic acid or oxalic acid, it is excreted with excrement.Thus this kind of calcium supplementing product, calcium
Human body utilization rate it is extremely low, long-term use is also possible to cause the adverse reactions such as constipation, and there are the risks of calculi in urinary system.
Disclosed in a kind of compound calcium preparation for astronaut, CN200810079874.5 disclosed in CN200510123442.6
A kind of high milk calcium granule disclosed in a kind of health products and CN200610023698.4 improving bone and function of joint,
These three calcium-supplementing preparations add a certain amount of oligosaccharide, improve the absorptivity of calcium to a certain extent, reduce by replenishing the calcium
The constipation problem of initiation.But since oligosaccharide is different from intestinal flora producing level, flatulence or hydrochloric acid in gastric juice etc. can be caused, especially
Be not suitable for the crowd of function of intestinal canal weakness.
Therefore, develop it is a kind of it is safer, reasonable, effectively nutritional composition for calcium supplement is still very urgent.
Invention content
The purpose of the present invention is to provide a kind of composition of safely and effectively replenishing the calcium, which has higher calcium
Absorptivity and bioavailability, at the same can effectively prevent or reduce as replenish the calcium it is improper caused by constipation and calculi in urinary system, this
It can also assist reducing blood pressure outside, blood glucose and blood lipid level.
To solve the above problems, the present invention adopts the following technical scheme that：
A kind of nutritional composition for calcium supplement, including calcium, oligosaccharide and tea is smeared, and the mass ratio of three is calcium: oligosaccharide: smear
Tea is 1: 0.3-6: 0.1-2.
Oligosaccharide itself, which has, to be promoted calcium uptake, promotes the activation of Bifidobacterium in human body intestinal canal and maintain intestinal health
Function.In addition the short chain fatty acids generated when oligosaccharide ferments can stimulate intestines peristalsis, increase excrement wettability, Constipation.
It is higher and smear the vitamin C in tea and can promote because smearing tea calcium content itself to be added in nutritional composition for calcium supplement and smear tea
Absorption into human body to calcium.It smears tea and also contains abundant active material such as catechin, tea polysaccharide etc., blood fat, blood glucose water can be reduced
It is flat, increase urinary calculi, to alleviate constipation caused by the insoluble calcium after calcium uptake, prevents calculi in urinary system, especially
The suitable the three high patients for needing to replenish the calcium.
The composition of replenishing the calcium of the present invention, it is determined that the formula ratio of three kinds of compositions, such combination not only ensure that three kinds of battalion
Supporting object, respectively effect gives full play to, and plays the role of synergy between each other：Smear the bacteriostasis and oligosaccharide of tea
Beneficial bacterium activation is combined, and the flora of enteron aisle has been better balanced, and effectively prevents producing sour aerogenesis phenomenon；It not only increases
The body absorption rate of calcium also adds the bioavailability of calcium, make eater after stopping supplementing alimentation composition of the present invention compared with
Still have good bone-forming effect without reversing in the long time.Importantly, such combination can realize reduction or
The effect of preventing calculi in urinary system, overcomes the drawbacks of existing calcium preparation easily leads to calculus, meets the three high patients and renal function
The not demand of the special physiologicals crowd to safely, effectively replenishing the calcium such as complete, functions of intestines and stomach decline crowd.
Preferably, calcium in the nutritional composition for calcium supplement：Oligosaccharide：The mass ratio for smearing tea is 1: 0.5-3: 0.3-1.
It replenishes the calcium in composition and calcium, oligosaccharide and to smear the ratio between tea, inventor has carried out a large amount of zoopery and faced
Bed experiment find three kinds of key compositional object calcium, oligosaccharide and smear tea mass ratio and this numerical value it is closer, calcium absorptivity is got over
Height, this, which fully shows suitable ratio, can enhance the synergistic function of three kinds of substances.
Preferably, calcium source in the nutritional composition for calcium supplement be newborn mineral salt, calcium phosphate, calcium monohydrogen phosphate, calcium carbonate,
One or more of amino acid chelated calcium.Phosphorus has a synergistic effect to the absorption of calcium, and natural phosphorous calcium source is then more easily
It absorbs, and without side-effects, too many hydrochloric acid in gastric juice is not needed in human body and participates in i.e. separable presentation ionic condition, and then is direct by human body
It is absorbed and utilized, adjusts blood calcium balance rapidly, builds up health, irritation is much smaller, substantially without repulsion and allergic phenomena.Amino acid chela
It is a kind of organic calcium substance generated by chemosynthesis reaction by a variety of amino acid and inorganic calcium salt to close calcium, can be significantly
Improve absorptivity of the human body to calcium.The calcium content highest of calcium carbonate（40%）, there is preferable therapeutic effect to osteoporosis, be suitble to
High calcium supplements crowd.
Preferably, the calcium is newborn mineral salt.Newborn mineral salt, which contains, coordinates rational 2: 1 calcium phosphorus ration, naturally occurring
Vitamin D, casein phosphopeptide（CPP）Equal natural nutrition compositions, both contribute to the absorption of calcium.It is compared with other calcium sources,
Ingredient is more abundant, and the absorbability of calcium is more preferable.
Preferably, the oligosaccharide in the nutritional composition for calcium supplement is trehalose, oligofructose, galactooligosaccharide, water
It is one or more in threose and isomaltoketose.Oligosaccharide significantly increases the absorption of calcium, and in enteron aisle
Bifidobacterium, the proliferation facilitation effect of lactobacillus acidophilus it is preferable.
Preferably, the tea fineness of smearing of the nutritional composition for calcium supplement is 800 mesh or more.Smear the increase of tea fineness so that
The active principle smeared in tea is more fully absorbed by the body, auxiliary replenish the calcium, adjust stomach, is hypoglycemic, reducing blood lipid the effect of more
Add apparent.
Preferably, further including promoting calcium enhancer vitamin D, K in the nutritional composition for calcium supplement2, in CPP, CBP one
Kind is several.The delivery of calcium can be participated in by promoting calcium enhancer, promote the absorption efficiency of calcium.
Preferably, also adding glycitols compound in the nutritional composition for calcium supplement.Sugar alcohol can effectively improve the suction of calcium
Yield and retention rate, and its sugariness is high, calorific value is low, does not make blood glucose rise, does not increase cholesterol, thus body fat can be reduced
Build up, and can prevent and adjuvant treatment of diseases.Since the stability of sugar alcohol is good, the matter that preparation more can guarantee product is made
Amount.Meanwhile the refrigerant mouthfeel of sugar alcohol can neutralize the astringent taste of calcium, and composition is made to have excellent mouthfeel.
Preferably, the nutritional composition for calcium supplement includes oral administration solid, liquid or semisolid preparation, such as chewable tablets, thin
Film garment piece, capsule, powders and granules etc..
Preferably, the nutritional composition for calcium supplement is applied to replenish the calcium, protects intestinal health, reduction or prevent urinary system
Calculus.
In conclusion the invention has the advantages that：
1, the nutritional composition for calcium supplement prepared according to ratio of the present invention not only ensure that respectively effect is filled for three nutrients
Distribution is waved, and plays the role of synergy between each other.
2, nutritional composition for calcium supplement of the present invention not only substantially increases the absorptivity of calcium, bioavailability, moreover it is possible to prevent or
The drawbacks of reducing constipation and calculi in urinary system caused by incorrect replenish the calcium, overcoming existing calcium preparation, is particularly suitable for kidney function
Mid-aged population that can be weaker.
3, nutritional composition for calcium supplement of the invention, other than there is good effect of supplemented calcium, moreover it is possible to auxiliary reduces blood pressure,
It is edible to be particularly suitable for three high crowd of person in middle and old age for blood fat and blood glucose.
Specific implementation mode
Realization, functional characteristics and the advantageous effect of purpose are further illustrated the present invention below in conjunction with specific embodiment.This
Specific embodiment is only explanation of the invention, is not limitation of the present invention, and those skilled in the art are reading
The modification of not creative contribution can be made after this specification to the present embodiment as needed, but as long as in the right of the present invention
It is all protected by Patent Law in claimed range.
1. nutritional composition for calcium supplement
Embodiment 1
Weigh mass percent be 50% amino acid chelated calcium, 20% trehalose, 10% oligofructose, 10% smear tea,
9.998% xylitol, 0.002% vitamin D powder.After mixing by all supplementary materials, then 5.0g/ bags are distributed into get replenishing the calcium
Nutrient combination medicinal powder.
Embodiment 2
Mass percent is weighed to be 10% calcium monohydrogen phosphate, 7.1% calcium phosphate, 15% galactooligosaccharide, 5% smear tea, 37.65%
Maltodextrin, 25% whole milk powder, 0.2% magnesium stearate, 0.05%CPP.First above-mentioned supplementary material is uniformly mixed, is added suitable
Purified water granulation, drying are measured, up to the film coated tablet of nutritional composition for calcium supplement after tabletting, coating.
Embodiment 3
Weigh mass percent be 43.5% calcium monohydrogen phosphate, 10% stachyose, 3% smear tea, 1% mulberry leaf powder, 20% xylose
Alcohol, 22.3% maltodextrin, 0.2% magnesium stearate.After mixing by above-mentioned supplementary material, it is filled with capsule filler, warp
Up to nutrient combination composite capsule after polishing, packing.
Embodiment 4
Weigh mass percent be 40% newborn mineral salt, 5% isomaltoketose, 5% smear tea, 0.05% farnoquinone,
30% maltitol, 19.85% whole-fat milk powder, 0.05%CMC, 0.05% potassium sorbate.It is fully molten that suitable quantity of water first is added in CMC
It is swollen uniformly after, add above-mentioned supplementary material and be uniformly mixed, sterilizing, after quantitative separating up to nutritional composition for calcium supplement oral solution.
Embodiment 5
Weigh mass percent be 37.5% newborn mineral salt, 5% oligofructose, 3% smear tea, 31% maltitol, 15%
Whole-fat milk powder, 8.2% maltodextrin, 0.3% magnesium stearate, calcium, oligosaccharide and smear tea three's mass ratio be 1:0.5:
0.3.After mixing by above-mentioned supplementary material, up to nutritional composition for calcium supplement chewable tablets after granulation, drying, tabletting.
Embodiment 6
Weigh mass percent be 20% newborn mineral salt, 25% oligofructose, 10% smear tea, 21.5% maltitol, 15%
Whole-fat milk powder, 8.2% maltodextrin, 0.3% magnesium stearate, calcium, oligosaccharide and smear tea three's mass ratio be 1:5:2.
After mixing by above-mentioned supplementary material, up to nutritional composition for calcium supplement chewable tablets after granulation, drying, tabletting.
Embodiment 7
Weigh mass percent be 20% newborn mineral salt, 10% oligofructose, 5% smear tea, 35% maltitol, 15%
Whole-fat milk powder, 14.8% maltodextrin, 0.3% magnesium stearate, calcium, oligosaccharide and smear tea three's mass ratio be 1:2:1.It will
Above-mentioned supplementary material after mixing, up to nutritional composition for calcium supplement chewable tablets after granulation, drying, tabletting.
Embodiment 8
Weigh mass percent be 37.5% calcium carbonate, 5% xylo-oligosaccharide, 1.5% smear tea, 19.5% skimmed milk power, 30%
Isomalt, 5.9% maltodextrin, 0.5% CBP, 0.1% milk flavour, calcium, oligosaccharide and smear tea three's mass ratio and be
1:0.3:0.1.After mixing by above-mentioned supplementary material, up to nutritional composition for calcium supplement particle after granulation, drying, packing.
Embodiment 9
Weigh mass percent be 25% calcium carbonate, 20% xylo-oligosaccharide, 10% smear tea, 19.5% skimmed milk power, 19% benefit
Longevity sugar, 5.9% maltodextrin, 0.5% CBP, 0.1% milk flavour, calcium, oligosaccharide and smear tea three's mass ratio be 1:
2:1.After mixing by above-mentioned supplementary material, up to nutritional composition for calcium supplement particle after granulation, drying, packing.
Embodiment 10
Weigh mass percent be 12.5% calcium carbonate, 30% xylo-oligosaccharide, 10% smear tea, 19.5% skimmed milk power, 21.5%
Isomalt, 5.9% maltodextrin, 0.5% CBP, 0.1% milk flavour, calcium, oligosaccharide and smear tea three's mass ratio
It is 1:6:2.After mixing by above-mentioned supplementary material, up to nutritional composition for calcium supplement particle after granulation, drying, packing.
Embodiment 11
Weigh mass percent be 36% newborn mineral salt, 5% trehalose, 5% galactooligosaccharide, 2% smear tea, 4% mulberry leaf
Powder, 20% maltitol, 15% skimmed milk powder, 12.8% maltodextrin, 0.2% magnesium stearate.Above-mentioned supplementary material is mixed
After closing uniformly, up to nutritional composition for calcium supplement chewable tablets after granulation, drying, tabletting.
Comparative example 1
Weigh mass percent be 37.5% calcium carbonate, 5% xylo-oligosaccharide, 19.5% skimmed milk power, 31.5% isomalt,
5.9% maltodextrin, 0.5% CBP, 0.1% milk flavour.After mixing by above-mentioned supplementary material, through granulation, drying, point
Up to nutritional composition for calcium supplement particle after dress.
Comparative example 2
Weigh mass percent be 37.5% calcium carbonate, 5% xylo-oligosaccharide, 1.2% smear tea, 19.5% skimmed milk power, 30%
Isomalt, 6.2% maltodextrin, 0.5% CBP, 0.1% milk flavour, calcium, oligosaccharide and smear tea three's mass ratio and be
1:0.3:0.08.After mixing by above-mentioned supplementary material, up to nutritional composition for calcium supplement particle after granulation, drying, packing.
Comparative example 3
Weigh mass percent be 12.5% calcium carbonate, 30% xylo-oligosaccharide, 10.5% smear tea, 20% skimmed milk power, 20.5%
Isomalt, 5.9% maltodextrin, 0.5% CBP, 0.1% milk flavour, calcium, oligosaccharide and smear tea three's mass ratio
It is 1:6:2.1.After mixing by above-mentioned supplementary material, up to nutritional composition for calcium supplement particle after granulation, drying, packing.
Comparative example 4
Weigh mass percent be 37.5% newborn mineral salt, 5% white granulated sugar, 3% smear tea, 31% maltitol, 15% it is complete
Fat milk powder, 8.2% maltodextrin, 0.3% magnesium stearate.After mixing by above-mentioned supplementary material, through granulation, drying, tabletting
Afterwards up to nutritional composition for calcium supplement chewable tablets.
Comparative example 5
Weigh mass percent be 20% newborn mineral salt, 25% oligofructose, 10.2% smear tea, 21.3% maltitol,
15% whole-fat milk powder, 8.2% maltodextrin, 0.3% magnesium stearate, calcium, oligosaccharide and smear tea three's mass ratio be 1:5:
2.5.After mixing by above-mentioned supplementary material, up to nutritional composition for calcium supplement chewable tablets after granulation, drying, tabletting.
Comparative example 6
Weigh mass percent be 37.5% newborn mineral salt, 2.5% oligofructose, 5% smear tea, 31.5% maltitol,
15% whole-fat milk powder, 8.2% maltodextrin, 0.3% magnesium stearate, calcium, oligosaccharide and smear tea three's mass ratio be 1:
0.28:0.5.After mixing by above-mentioned supplementary material, up to nutritional composition for calcium supplement chewable tablets after granulation, drying, tabletting.
2. the animal experiment of effect of supplemented calcium：
Experiment 10 monthly age cleaning grade male SD rats, weight 300-330g.It is adapted under identical environment after feeding 1 week, with
Machine is divided into 7 groups：It tests 1 group, 2 groups of experiment, 3 groups of experiment, blank group, 1 group of control, 2 groups of control, compare 3 groups, every group 10.Greatly
Mouse drinks+1% chlorination ammonium hydroxide of 1% ethylene glycol（Induced rat generates calcinm oxalate calculus）, weigh weekly primary, feed 5 weeks.Ensure every
The calcium intake of rat is about 150mg/d.
Embodiment 12
It tests and is added with nutritional composition for calcium supplement in the feed of 1 group of rat, the nutritional composition for calcium supplement preparation method is such as
Embodiment 6, rat calcium intake are about 150mg/d.
Every rat is collected after experiment with metabolic cage to urinate for 24 hours, enriching hydrochloric acid anti-corrosion, 4 DEG C of preservations.Potassium chromate aoxidizes first
The red Catalytic Spectrophotometric Analysis of base surveys urine oxalic acid, and measures urinary calcium concentration.
Rat weight, 4% yellow Jackets（40mg/kg）Left side internal carotid artery is isolated in intraperitoneal anesthesia, at the neck that then breaks
Extremely.Double kidneys are taken out, are longitudinally splitted, left kidney is fixed with 10% formaldehyde, HE dyed paraffins slice, 200 times of light microscopic observation nephridial tissue grass
Sour calcium crystallization deposition situation.
Embodiment 13
It tests and is added with nutritional composition for calcium supplement in the feed of 2 groups of rats, the nutritional composition for calcium supplement preparation method is such as
Embodiment 9, rat calcium intake are about 150mg/d.
Every rat is collected after experiment with metabolic cage to urinate for 24 hours, enriching hydrochloric acid anti-corrosion, 4 DEG C of preservations.Potassium chromate aoxidizes first
The red Catalytic Spectrophotometric Analysis of base surveys urine oxalic acid, and measures urinary calcium concentration.
Rat weight, 4% yellow Jackets（40mg/kg）Left side internal carotid artery is isolated in intraperitoneal anesthesia, at the neck that then breaks
Extremely.Double kidneys are taken out, are longitudinally splitted, left kidney is fixed with 10% formaldehyde, HE dyed paraffins slice, 200 times of light microscopic observation nephridial tissue grass
Sour calcium crystallization deposition situation.
Embodiment 14
It tests and is added with nutritional composition for calcium supplement in the feed of 3 groups of rats, the nutritional composition for calcium supplement preparation method is such as
Embodiment 10, rat calcium intake are about 150mg/d.
Every rat is collected after experiment with metabolic cage to urinate for 24 hours, enriching hydrochloric acid anti-corrosion, 4 DEG C of preservations.Potassium chromate aoxidizes first
The red Catalytic Spectrophotometric Analysis of base surveys urine oxalic acid, and measures urinary calcium concentration.
Rat weight, 4% yellow Jackets（40mg/kg）Left side internal carotid artery is isolated in intraperitoneal anesthesia, at the neck that then breaks
Extremely.Double kidneys are taken out, are longitudinally splitted, left kidney is fixed with 10% formaldehyde, HE dyed paraffins slice, 200 times of light microscopic observation nephridial tissue grass
Sour calcium crystallization deposition situation.
Comparative example 7
Blank group feeding normal diet.
Every rat is collected after experiment with metabolic cage to urinate for 24 hours, enriching hydrochloric acid anti-corrosion, 4 DEG C of preservations.Potassium chromate aoxidizes first
The red Catalytic Spectrophotometric Analysis of base surveys urine oxalic acid, and measures urinary calcium concentration.
Rat weight, 4% yellow Jackets（40mg/kg）Left side internal carotid artery is isolated in intraperitoneal anesthesia, at the neck that then breaks
Extremely.Double kidneys are taken out, are longitudinally splitted, left kidney is fixed with 10% formaldehyde, HE dyed paraffins slice, 200 times of light microscopic observation nephridial tissue grass
Sour calcium crystallization deposition situation.
Comparative example 8
It compares and is added with nutritional composition for calcium supplement in the feed of 1 group of rat, the nutritional composition for calcium supplement preparation method is such as
Such as comparative example 1, rat calcium intake is about 150mg/d.
Every rat is collected after experiment with metabolic cage to urinate for 24 hours, enriching hydrochloric acid anti-corrosion, 4 DEG C of preservations.Potassium chromate aoxidizes first
The red Catalytic Spectrophotometric Analysis of base surveys urine oxalic acid, and measures urinary calcium concentration.
Rat weight, 4% yellow Jackets（40mg/kg）Left side internal carotid artery is isolated in intraperitoneal anesthesia, at the neck that then breaks
Extremely.Double kidneys are taken out, are longitudinally splitted, left kidney is fixed with 10% formaldehyde, HE dyed paraffins slice, 200 times of light microscopic observation nephridial tissue grass
Sour calcium crystallization deposition situation.
Comparative example 9
It compares and is added with nutritional composition for calcium supplement in the feed of 2 groups of rats, the nutritional composition for calcium supplement preparation method is such as
Comparative example 2, rat calcium intake are about 150mg/d.
Every rat is collected after experiment with metabolic cage to urinate for 24 hours, enriching hydrochloric acid anti-corrosion, 4 DEG C of preservations.Potassium chromate aoxidizes first
The red Catalytic Spectrophotometric Analysis of base surveys urine oxalic acid, and measures urinary calcium concentration.
Rat weight, 4% yellow Jackets（40mg/kg）Left side internal carotid artery is isolated in intraperitoneal anesthesia, at the neck that then breaks
Extremely.Double kidneys are taken out, are longitudinally splitted, left kidney is fixed with 10% formaldehyde, HE dyed paraffins slice, 200 times of light microscopic observation nephridial tissue grass
Sour calcium crystallization deposition situation.
Comparative example 10
It compares and is added with nutritional composition for calcium supplement in the feed of 3 groups of rats, the nutritional composition for calcium supplement preparation method is such as
Comparative example 3, rat calcium intake are about 150mg/d.
Every rat is collected after experiment with metabolic cage to urinate for 24 hours, enriching hydrochloric acid anti-corrosion, 4 DEG C of preservations.Potassium chromate aoxidizes first
The red Catalytic Spectrophotometric Analysis of base surveys urine oxalic acid, and measures urinary calcium concentration.
Rat weight, 4% yellow Jackets（40mg/kg）Left side internal carotid artery is isolated in intraperitoneal anesthesia, at the neck that then breaks
Extremely.Double kidneys are taken out, are longitudinally splitted, left kidney is fixed with 10% formaldehyde, HE dyed paraffins slice, 200 times of light microscopic observation nephridial tissue grass
Sour calcium crystallization deposition situation.
Table 1：Animal test results
（Note：With blank group rat renal tubule crystalline state in comparative example 7 for 10 points, represents and crystallize closer to 10 points
It is coarseer, in heaps and to tend to connection in blocks；Score is lower, represents and crystallizes more tiny, dispersion, and crystallization bright spot is smaller）
As shown in table 1, the rat urine oxalic acid value of experimental group, renal tubule crystallization score value are less than blank group and control group, urine
Calcium value is higher than blank group and control group, this shows that nutritional composition for calcium supplement of the present invention can reduce calculi in urinary system risk.It is real
Test group nutritional composition for calcium supplement of rat institute feeding while adding oligosaccharide, calcium and smearing tea, and 8 groups of rats of comparative example with
Difference lies in no additions to smear tea for experimental group, although 9 groups of comparative example, 10 groups contain calcium, oligosaccharide simultaneously and smear tea,
It is the mass ratio of three not in calcium: oligosaccharide: smears tea=1: in the range of 0.3-6: 0.1-2.From rat urine oxalic acid, urinary calcium,
The numerical value such as renal tubule crystallization can be seen that each numerical value of experimental group is substantially better than control group, and urine oxalic acid crystallization has the tendency that reduction.
This shows that calcium in nutritional composition for calcium supplement, oligosaccharide and the appropriate proportioning of smearing tea have preferable work to slowing down for calculi in urinary system
With.
3. clinical test：
Experiment crowd：Using random sampling group technology, selection 60 is through clinical definite hypertension and with osteoporosis
The middle-aged and the old, age 40-70 Sui, and be randomly divided into experimental group 1, experimental group 2, experimental group 3, blank group, compare 1 group, is right
According to 2 groups, 3 groups, every group 8 of control.Calcium intake reaches 800mg/d.Initial blood pressure, blood glucose, bone density value, weight are measured, is seen
Examine stool situation.
Embodiment 15
The nutritional composition for calcium supplement of daily ingestion of the present embodiment of experimental group 5, makes calcium intake reach 800mg.After three months,
Its blood pressure, blood glucose, bone density, weight are measured.Its femoral neck bone density is measured using Dual-energy X-rays absorptionmetry（BMD）.
Embodiment 16
The nutritional composition for calcium supplement of daily ingestion of the present embodiment of experimental group 6, makes calcium intake reach 800mg.After three months,
Its blood pressure, blood glucose, bone density, weight are measured.Its femoral neck bone density is measured using Dual-energy X-rays absorptionmetry（BMD）.
Embodiment 17
The nutritional composition for calcium supplement of daily ingestion of the present embodiment of experimental group 7, makes calcium intake reach 800mg.After three months,
Its blood pressure, blood glucose, bone density, weight are measured.Its femoral neck bone density is measured using Dual-energy X-rays absorptionmetry（BMD）.
Comparative example 11
Blank group still presses normal diet, does not take any nutritional composition for calcium supplement.After three months, to its blood pressure, blood glucose, bone
Density, weight are measured.Its femoral neck bone density is measured using Dual-energy X-rays absorptionmetry（BMD）.
Comparative example 12
1 group is compareed, the nutritional composition for calcium supplement of daily ingestion of comparative example 4 makes calcium intake reach 800mg.Three
After month, its blood pressure, blood glucose, bone density, weight are measured.Its femoral neck bone density is measured using Dual-energy X-rays absorptionmetry
（BMD）.
Comparative example 13
2 groups are compareed, the nutritional composition for calcium supplement of daily ingestion of comparative example 5 makes calcium intake reach 800mg.Three
After month, its blood pressure, blood glucose, bone density, weight are measured.Its femoral neck bone density is measured using Dual-energy X-rays absorptionmetry
（BMD）.
Comparative example 14
2 groups are compareed, the nutritional composition for calcium supplement of daily ingestion of comparative example 6 makes calcium intake reach 800mg.Three
After month, its blood pressure, blood glucose, bone density, weight are measured.Its femoral neck bone density is measured using Dual-energy X-rays absorptionmetry
（BMD）.
2 clinical trial results of table
As shown in table 2, the nutritional composition for calcium supplement of the present invention that experimental group patient takes contains calcium, smears tea and oligomeric simultaneously
Sugar, blank group does not take any calcium-supplementing nutritive object, and compares the calcium-supplementing preparation that 1 group of patient takes and be free of oligosaccharide, 2 groups of control, 3
Calcium in group: the mass ratio of tea oligosaccharide: is smeared not in the range of 1: 0.3-6: 0.1-2.
Experimental data in table 2 shows that experimental group patient's systolic pressure decreasing value, fasting blood-glucose decreasing value, bone density increase
Value is substantially better than control group patient, illustrates that nutritional composition for calcium supplement of the present invention while increasing bone density, additionally aids drop blood
Pressure, blood glucose, replenish the calcium suitable for hypertension, hyperglycemic patients.In addition, stool frequency data and changes of weight statistics indicate that this
Invention nutritional composition for calcium supplement more helps relax bowel, and loses weight.Compared with experimental group, the contraction of 2 groups and 3 groups patients is compareed
The physical signs such as decreasing value, fasting blood sugar, urinary calcium, bone density value added are pressed also to be significantly lower than experimental group, this shows the battalion that replenishes the calcium
Support composition in calcium, oligosaccharide and smear tea proportioning whether properly to they human body calcium uptake, blood pressure and blood sugar level reduction,
It is most important whether increase of bone density etc. plays synergistic function.
Claims (8)
1. a kind of nutritional composition for calcium supplement, it is characterised in that：The nutritional composition for calcium supplement includes calcium, oligosaccharide and smears tea, calcium:
Oligosaccharide: the mass ratio for smearing tea is 1: 0.5~3: 0.3~1；The tea fineness of smearing is at least 800 mesh.
2. a kind of nutritional composition for calcium supplement as described in claim 1, it is characterised in that：The calcium is newborn mineral salt, calcium phosphate, phosphorus
One or more of sour hydrogen calcium, calcium carbonate, amino acid chelated calcium.
3. a kind of nutritional composition for calcium supplement as claimed in claim 2, it is characterised in that：The calcium is newborn mineral salt.
4. a kind of nutritional composition for calcium supplement as described in claim 1, it is characterised in that：The oligosaccharide is trehalose, oligomeric fruit
It is one or more in sugar, galactooligosaccharide, stachyose and isomaltoketose.
5. a kind of nutritional composition for calcium supplement as claimed in claim 4, it is characterised in that：The nutritional composition for calcium supplement further includes promoting
Calcium enhancer vitamin D, K2, one or more of CPP, CBP.
6. a kind of nutritional composition for calcium supplement as claimed in claim 5, it is characterised in that：The nutritional composition for calcium supplement further includes sugar
Alcohol compound.
7. a kind of nutritional composition for calcium supplement as claimed in claim 6, it is characterised in that：The nutritional composition for calcium supplement includes solid
Body, liquid and semisolid oral formulations.
8. a kind of nutritional composition for calcium supplement as described in claim any one of 1-7, it is characterised in that：The nutritional composition for calcium supplement
Applied to replenish the calcium, protect intestinal health, reduction or prevent calculi in urinary system.
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| WO2004000045A2 (en) * | 2002-06-21 | 2003-12-31 | Canacure Corporation | Liquid compositions comprising non-digestible oligosaccharides and green tea catechins, method and uses thereof |
| CN1579233A (en) * | 2003-08-10 | 2005-02-16 | 西安大鹏生物科技股份有限公司 | Calcium-cupplemeuting health food containing stachyose |
| CN1785427A (en) * | 2005-11-21 | 2006-06-14 | 陈斌 | Compound calcium preparation for astronaut |
| JP2009106216A (en) * | 2007-10-31 | 2009-05-21 | Tsujido Kagaku Kk | Calcium absorption promoter |
| CN101720883A (en) * | 2009-11-26 | 2010-06-09 | 山东龙力生物科技股份有限公司 | Application of xylooligosaccharide used as calcium absorption enhancer |
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2015
- 2015-12-31 CN CN201511014069.0A patent/CN105581331B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004000045A2 (en) * | 2002-06-21 | 2003-12-31 | Canacure Corporation | Liquid compositions comprising non-digestible oligosaccharides and green tea catechins, method and uses thereof |
| CN1579233A (en) * | 2003-08-10 | 2005-02-16 | 西安大鹏生物科技股份有限公司 | Calcium-cupplemeuting health food containing stachyose |
| CN1785427A (en) * | 2005-11-21 | 2006-06-14 | 陈斌 | Compound calcium preparation for astronaut |
| JP2009106216A (en) * | 2007-10-31 | 2009-05-21 | Tsujido Kagaku Kk | Calcium absorption promoter |
| CN101720883A (en) * | 2009-11-26 | 2010-06-09 | 山东龙力生物科技股份有限公司 | Application of xylooligosaccharide used as calcium absorption enhancer |
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Denomination of invention: A calcium supplement nutritional composition Effective date of registration: 20230505 Granted publication date: 20180824 Pledgee: Hangzhou United Rural Commercial Bank Limited by Share Ltd. Zhongshan branch Pledgor: ZHEJIANG CANOBANK HEALTH PRODUCT Co.,Ltd. Registration number: Y2023980039787 |
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