CN105566431B - 一种醋酸乌利司他的杂质及其制备和检测方法 - Google Patents
一种醋酸乌利司他的杂质及其制备和检测方法 Download PDFInfo
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- CN105566431B CN105566431B CN201610091024.1A CN201610091024A CN105566431B CN 105566431 B CN105566431 B CN 105566431B CN 201610091024 A CN201610091024 A CN 201610091024A CN 105566431 B CN105566431 B CN 105566431B
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- 0 CC1([C@]2(CCC3C4CC5)O)OCC*1C23C=C=C4C(CC1)=C5CC11OCCO1 Chemical compound CC1([C@]2(CCC3C4CC5)O)OCC*1C23C=C=C4C(CC1)=C5CC11OCCO1 0.000 description 3
- NNRHYMTXYVBQML-JCRBPUCRSA-N CC(CC1C(C=C2)=CCC2N(C)C)(C(CC2)C(CC3)C1=C(CC1)C3=CC1=O)[C@H]2C(C)=O Chemical compound CC(CC1C(C=C2)=CCC2N(C)C)(C(CC2)C(CC3)C1=C(CC1)C3=CC1=O)[C@H]2C(C)=O NNRHYMTXYVBQML-JCRBPUCRSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
波长 | 杂质 |
302nm | 杂质D、E、F、K |
237nm | 杂质B、C |
258nm | 杂质A、G、H、I、J |
时间(分) | A% | B% |
0 | 90 | 10 |
30 | 40 | 60 |
60 | 40 | 60 |
波长 | 杂质 |
302nm | 杂质D、E、F、K |
237nm | 杂质B、C |
258nm | 杂质A、G、H、I、J |
Claims (4)
Priority Applications (1)
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CN201610091024.1A CN105566431B (zh) | 2016-02-19 | 2016-02-19 | 一种醋酸乌利司他的杂质及其制备和检测方法 |
Applications Claiming Priority (1)
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CN201610091024.1A CN105566431B (zh) | 2016-02-19 | 2016-02-19 | 一种醋酸乌利司他的杂质及其制备和检测方法 |
Publications (2)
Publication Number | Publication Date |
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CN105566431A CN105566431A (zh) | 2016-05-11 |
CN105566431B true CN105566431B (zh) | 2017-11-24 |
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CN201610091024.1A Active CN105566431B (zh) | 2016-02-19 | 2016-02-19 | 一种醋酸乌利司他的杂质及其制备和检测方法 |
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CN (1) | CN105566431B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109369766A (zh) * | 2018-10-31 | 2019-02-22 | 常州四药制药有限公司 | 醋酸乌利司他相关手性杂质及其合成制备方法 |
CN112194699A (zh) * | 2020-11-12 | 2021-01-08 | 湖南新合新生物医药有限公司 | 一种醋酸乌利司他杂质对照品的制备方法 |
CN112578037A (zh) * | 2020-11-12 | 2021-03-30 | 湖南新合新生物医药有限公司 | 一种检测醋酸乌利司他中间体ⅰ中乌双缩酮含量的方法 |
CN112461957B (zh) * | 2020-11-12 | 2022-02-22 | 湖南新合新生物医药有限公司 | 一种检测醋酸乌利司他中间体ii中杂质含量的方法 |
CN112540156B (zh) * | 2020-11-21 | 2022-11-08 | 山东飞扬化工有限公司 | 一种用物理方法检测发酵液中杂酸的装置及方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2854402B1 (fr) * | 2003-04-29 | 2008-07-04 | Aventis Pharma Sa | Nouveau procede et intermediaires de preparation de composes 19-nor-steroides |
CN102516345B (zh) * | 2011-11-01 | 2014-11-26 | 上海优拓医药科技有限公司 | 醋酸乌利司他及其关键中间体的制备方法 |
CN102399253B (zh) * | 2011-11-23 | 2015-12-09 | 北京市科益丰生物技术发展有限公司 | 一种坦勃龙醋酸酯的制备方法 |
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2016
- 2016-02-19 CN CN201610091024.1A patent/CN105566431B/zh active Active
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Application publication date: 20160511 Assignee: Pharmaceutical Co., Ltd., Changzhou Pharmaceutical Factory No.4 Assignor: Changzhou City No.4 Pharmaceutical Factory Co., Ltd. Contract record no.: 2018320000315 Denomination of invention: Ulipristal acetate impurities and preparation and detection method thereof Granted publication date: 20171124 License type: Exclusive License Record date: 20181114 |
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Effective date of registration: 20191213 Address after: 213018 No. 567 Wu Cheng Road, Changzhou, Jiangsu Co-patentee after: Pharmaceutical Co., Ltd., Changzhou Pharmaceutical Factory No.4 Patentee after: Changzhou City No.4 Pharmaceutical Factory Co., Ltd. Address before: 213004 Jiangsu province Changzhou City Palace Road No. 168 Patentee before: Changzhou City No.4 Pharmaceutical Factory Co., Ltd. |