CN105560827A - 一种用于围绝经期综合征调理的药膏及其制备方法 - Google Patents
一种用于围绝经期综合征调理的药膏及其制备方法 Download PDFInfo
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Abstract
本发明提供了一种用于围绝经期综合征调理的药膏，由以下重量分数的原料制成：阿胶10－20份，龟甲胶10－20份，山药5－10份，枸杞子5－10份，桑葚5－10份，葛根5－8份，黄精5－10份，肉桂3－5份，茯苓5－10份，酸枣仁8－12份，知母8－12份，甘草8－12份，核桃仁10－40份，黑芝麻10－40份，冰糖10－20份，黄酒20－60份。本发明提供的药膏可有效调理围绝经期的精神及生理状态，并且通过补血等调理改善潮热、出汗、心悸、胸闷、腰颈酸痛、焦虑等症状。
Description
技术领域
本发明涉及医药保健领域，具体涉及一种用于围绝经期综合征调理的药膏及其制备方法。
背景技术
围绝经期是指妇女绝经前后的一段时期，从45岁左右开始至停经后12个月内的时期，包括从接近绝经出现与绝经有关的内分泌、生物学和临床特征起至最后1次月经后1年，也就是卵巢功能衰退的征兆，一直持续到最后1次月经后1年，是正常的生理变化时期。
但是，女性在围绝经期由于卵巢功能衰退，体内***水平下降导致神经内分泌调节机制失衡而出现的一系列症状，如潮热、出汗、心悸、胸闷、腰颈酸痛、焦虑等，被称为“围绝经期综合征”。妇女经断之年，肾气渐衰，肾精不足，冲任脉虚，机体处于一种特殊的生理状态。由于肾阴不足，阳失潜藏或肾阳虚衰，经脉失养，从而导致脏腑功能失调，故肾虚是致病之本。肾脏精气亏虚，必然累及八脉，肾水不足，不能化气，而致血瘀。
目前，西医采用激素替代疗法，通过补充外源性的雌、孕激素而改善围绝经期症状，但是近年来美国激素替代疗法临床实验研究显示，连续联合增加心脏病事件、脑卒中、乳腺癌及肺栓塞等有风险。根据中医理论及实践证明长期的食物及中药调理可以显著的改善或减缓围绝经期综合征的症状，可使广大女性平稳的度过围绝经期。
中国专利201510343876.0公开了一种治疗围绝经期综合症的中药制剂，具体中药包括熟附子(先煎)10g、灵磁石(先煎)30g、煅龙骨(先煎)30g、熟地黄10g、山茱萸10g、怀牛膝10g、浮小麦10g、五味子6g、炙甘草6g。方中熟附子、灵磁石、煅龙骨温肾潜阳为君，熟地黄、山茱萸、五味子纳肾填精为臣，浮小麦、炙甘草养心敛汗为佐，怀牛膝引经为使。全方共奏补益心肾，引火归元之功。
中国专利201510329489.1公开了一种治疗围绝经期综合症的中药组合物，由如下重量份数的中药原料制成：仙茅10、黄柏10、仙灵脾15、巴戟天15、知母12、生地30、女贞子15、旱莲草15、生龙骨30、生牡蛎30、珍珠母30、当归20，具有滋肾益阴，补肾扶阳的功效。
发明内容
本发明的一个目的在于，提供一种用于围绝经期综合征调理的药膏，该药膏能够从根本上改善患者肾虚症状，同时具有滋阴养血、补脾养胃的功效。
本发明的另一个目的在于提供制备所述药膏的方法。
为了实现上述目的，本发明的具体方案如下：
一种用于围绝经期综合征调理的药膏，由以下重量分数的原料制成：
阿胶10－20份，龟甲胶10－20份，山药5－10份，枸杞子5－10份，桑葚5－10份，葛根5－8份，黄精5－10份，肉桂3－5份，茯苓5－10份，酸枣仁8－12份，知母8－12份，甘草8－12份，核桃仁10－40份，黑芝麻10－40份，冰糖10－20份，黄酒20－60份。
本发明还提供了制备用于围绝经期综合征调理的药膏的方法，包括以下步骤：
(1)粉碎：称取所述份数的阿胶和龟甲胶，混合粉碎至80－100目，备用；
(2)浓缩液制备：称取所述份数的山药、葛根、黄精、肉桂、茯苓、酸枣仁、知母、甘草，加入8倍重量的纯化水，回流煎煮2－2.5小时，过滤分别回收滤液和滤渣，将回收的所述滤渣经多次回流煎煮，将多次得到的滤液混合后减压浓缩至在70－75℃下相对密度为1.10－1.20，得浓缩液；
(3)化胶：在熬煮容器中加入所述份数的黄酒加热至沸腾，加入所述份数的冰糖，搅拌使其完全溶化后加入步骤(1)中粉碎的阿胶和龟甲胶，并不断搅拌至其完全熔化，得糖胶液；
(4)精炼：将步骤(2)所得的浓缩液加入步骤(3)中制得的所述糖胶液中，继续搅拌，浓缩至水分含量为40％－50％；
(5)混料：称取所述份数的枸杞、桑葚、核桃仁、黑芝麻，并将其加入步骤(4)中的浓缩液中，加热搅拌均匀，即得所述药膏。
本发明提供的一种用于围绝经期综合征调理的药膏，根据中药君、臣、佐、使的配伍机理，以阿胶、龟甲胶为君药，以山药、枸杞子、桑葚、葛根、黄精臣药，以肉桂、茯苓、酸枣仁、知母为佐药，以甘草、核桃仁、黑芝麻为使药。其中阿胶、龟甲胶主攻滋阴养血，山药、枸杞子、桑葚、葛根、黄精补脾养胃，滋补肝肾，集中达到补脾益气的功效，而肉桂、茯苓、酸枣仁、知母补火助阳、散寒止痛、利水渗湿，增强君药和臣药的功效，甘草、核桃仁、黑芝麻均味甘性平，有补脾益气、滋补肝肾的功效。
通过本发明提供的药膏，不仅服用方便，
同时，本发明提供的制备药膏的方法，不仅能使原料中的有效成分最大化地析出，而且对于原料中有效成分的利用率高，各成分之间的融合性高，相互协同能够发挥更好地功效，制成的阿胶糕中的营养成分对于体虚人群同样易于吸收，不会对肠胃造成负担。
本发明正是基于中医的内调配伍机理，在长期实践的基础上而发明的一款适于围绝经期女性长期服用的阿胶膏，其具有口感好，服用方便，效果显著，无副作用的优点。
剂型：为丸剂或膏剂。或者可以经过再加工处理呈散剂、颗粒剂、片剂、胶囊剂、膏剂中的任意一种。
本发明提供的药膏可有效调理围绝经期的精神及生理状态，并且通过补血等调理改善潮热、出汗、心悸、胸闷、腰颈酸痛、焦虑等症状。一般，视服用者的状况，每天可服用7.5－15克/次，每天2次。
此外，本品可作为食品长期服用，在感冒及月经期间暂停服用。
具体实施方式
实施例1：
用于围绝经期调理的阿胶膏，包括以下重量份数的原料：阿胶10份，龟甲胶10份，山药5份，枸杞子5份，桑葚5份，葛根5份，黄精5份，肉桂3份，茯苓5份，酸枣仁8份，知母8份，甘草8份，核桃15份，黑芝麻15份，冰糖10份，黄酒30份。
阿胶膏的制备方法，包括以下步骤：
(1)粉碎：称取阿胶10份，龟甲胶10份，用打粉机粉碎至80－100目，备用。
(2)浓缩液制备：称取山药5份，葛根5份，黄精5份，肉桂3份，茯苓5份，酸枣仁8份，知母8份，甘草8份，加入8倍重量的纯化水，回流煎煮2小时，过滤得滤液a；在滤渣中加入初始药材3倍重量的纯化水，回流煎煮2小时，过滤得滤液b；在滤液渣中加入初始药材3倍量的纯化水，回流煎煮1小时，过滤得滤液c；将滤液a、b、c混合，进行减压浓缩，直到混合液的相对密度为1.10－1.20(70－75℃)，得浓缩液。
(3)化胶。在熬煮的容器中加入30份的黄酒加热至沸腾，加入10份冰糖，搅拌使其溶化。加入(1)中粉碎的阿胶和龟甲胶，并不断搅拌至其完全熔化，得糖胶液。
(4)精炼。将步骤(2)所得浓缩液加入步骤(3)的糖胶液，继续搅拌，浓缩至水分含量在40％－50％。
(5)混料。称取枸杞子5份，桑葚5份，核桃15份，黑芝麻15份，将其加入步骤(4)中的浓缩液中，并加热搅拌均匀，即得阿胶膏。
实施例2：
用于围绝经期调理的阿胶膏，包括以下重量份数的原料：阿胶15份，龟甲胶15份，山药8份，枸杞子8份，桑葚8份，葛根8份，黄精8份，肉桂4份，茯苓6份，酸枣仁10份，知母10份，甘草10份，核桃25份，黑芝麻25份，冰糖15份，黄酒40份。
本发明所述的阿胶膏的制备方法，包括以下步骤：
(1)粉碎：称取阿胶15份，龟甲胶15份，用打粉机粉碎至80－100目，备用。
(2)浓缩液制备：称取山药8份，葛根8份，黄精8份，肉桂4份，茯苓6份，酸枣仁10份，知母10份，甘草10份，加入8倍重量的纯化水，回流煎煮2小时，过滤得滤液a；在滤渣中加入初始药材3倍重量的纯化水，回流煎煮2小时，过滤得滤液b；在滤液渣中加入初始药材3倍量的纯化水，回流煎煮1小时，过滤得滤液c；将滤液a、b、c混合，进行减压浓缩，直到混合液的相对密度为1.10－1.20(70－75℃)，得浓缩液。
(3)化胶。在熬煮的容器中加入40份的黄酒加热至沸腾，加入15份冰糖，搅拌使其溶化。加入(1)中粉碎的阿胶和龟甲胶，并不断搅拌至其完全熔化，得糖胶液。
(4)精炼。将步骤(2)所得浓缩液加入步骤(3)的糖胶液，继续搅拌，浓缩至水分含量在40％－50％。
(5)混料。称取枸杞子8份，桑葚8份，核桃25份，黑芝麻25份，将其加入步骤(4)中的浓缩液中，并加热搅拌均匀，即得阿胶膏。
实验例：
使用实施例2制备的样品，在上海市某中医院对60位45－60岁月经不规律，有出汗、潮热、心烦、心悸、胸闷、乏力、失眠、记忆力减退、腰颈酸痛、焦虑、骨质疏松、血压波动等不同程度症状的女性，连续服用3个月，均得到不同程度的改善。
检测方法：问诊把脉，***、雌三醇、促卵泡素等指标检测。
结果显示：痊愈25例，好转30例，无效5例，总有效率为91.6％。
以上，虽然说明了本发明的几个实施方式，但是这些实施方式只是作为例子提出的，并非用于限定本发明的范围。对于这些新的实施方式，能够以其他各种方式进行实施，在不脱离本发明的要旨的范围内，能够进行各种省略、置换、及变更。这些实施方式和其变形，包含于本发明的范围和要旨中的同时，也包含于权利要求书中记载的发明及其均等范围内。
Claims (6)
1.一种用于围绝经期综合征调理的药膏，其特征在于，由以下重量分数的原料制成：
阿胶10－20份，龟甲胶10－20份，山药5－10份，枸杞子5－10份，桑葚5－10份，葛根5－8份，黄精5－10份，肉桂3－5份，茯苓5－10份，酸枣仁8－12份，知母8－12份，甘草8－12份，核桃仁10－40份，黑芝麻10－40份，冰糖10－20份，黄酒20－60份。
2.根据权利要求1所述的一种用于围绝经期综合征调理的药膏，其特征在于，由以下重量分数的原料制成：
阿胶12－18份，龟甲胶13－17份，山药6－8份，枸杞子6－9份，桑葚7－9份，葛根6－8份，黄精7－10份，肉桂3－4份，茯苓6－8份，酸枣仁9－11份，知母9－11份，甘草9－10份，核桃仁20－30份，黑芝麻20－30份，冰糖13－17份，黄酒30－45份。
3.根据权利要求1所述的一种用于围绝经期综合征调理的药膏，其特征在于，由以下重量分数的原料制成：
阿胶15份，龟甲胶18份，山药7份，枸杞子8份，桑葚8份，葛根7份，黄精9份，肉桂4份，茯苓7份，酸枣仁10份，知母10份，甘草10份，核桃仁25份，黑芝麻25份，冰糖15份，黄酒40份。
4.制备权利要求1－3任一项所述的用于围绝经期综合征调理的药膏的方法，其特征在于，包括以下步骤：
(1)粉碎：称取所述份数的阿胶和龟甲胶，混合粉碎至80－100目，备用；
(2)浓缩液制备：称取所述份数的山药、葛根、黄精、肉桂、茯苓、酸枣仁、知母、甘草，加入8倍重量的纯化水，回流煎煮2－2.5小时，过滤分别回收滤液和滤渣，将回收的所述滤渣经多次回流煎煮，将多次得到的滤液混合后减压浓缩至在70－75℃下相对密度为1.10－1.20，得浓缩液；
(3)化胶：在熬煮容器中加入所述份数的黄酒加热至沸腾，加入所述份数的冰糖，搅拌使其完全溶化后加入步骤(1)中粉碎的阿胶和龟甲胶，并不断搅拌至其完全熔化，得糖胶液；
(4)精炼：将步骤(2)所得的浓缩液加入步骤(3)中制得的所述糖胶液中，继续搅拌，浓缩至水分含量为40％－50％；
(5)混料：称取所述份数的枸杞、桑葚、核桃仁、黑芝麻，并将其加入步骤(4)中的浓缩液中，加热搅拌均匀，即得所述药膏。
5.根据权利要求4所述的用于围绝经期综合征调理的药膏的方法，其特征在于，
步骤(2)中，过滤分别回收滤液和滤渣，将回收的所述滤渣经多次回流煎煮，具体包括：
回收的所述滤液为初始滤液，在回收的所述滤渣中加入制备所述初始滤液的药材总重量3倍的纯化水，回流煎煮2－2.5小时，过滤得二级滤液，同时在回收的滤渣中同样再次加入3倍量的纯化水，回流煎煮1－1.5小时，过滤得三级滤液。
6.根据权利要求4所述的用于围绝经期综合征调理的药膏的方法，其特征在于，所述药膏的剂型为丸剂或膏剂。
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| CN108378189A (zh) * | 2018-01-04 | 2018-08-10 | 白洋 | 一种以中药膏方熬制的阿胶糖果及其制备方法 |
| CN109221994A (zh) * | 2018-09-20 | 2019-01-18 | 山东皇菴堂药业有限公司 | 一种凤巢葆 |
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| CN114010736A (zh) * | 2021-12-24 | 2022-02-08 | 中国人民解放军空军军医大学 | 调摄焦虑抑郁失眠症的中药组合物及其制备方法 |
| CN114010736B (zh) * | 2021-12-24 | 2023-06-02 | 中国人民解放军空军军医大学 | 中药组合物在制备改善非酒精性脂肪肝引起的焦虑抑郁失眠的药物中的应用 |
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