CN105535250A - Drug anesthesia preparation and preparation method and application thereof - Google Patents

Drug anesthesia preparation and preparation method and application thereof Download PDF

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Publication number
CN105535250A
CN105535250A CN201610045922.3A CN201610045922A CN105535250A CN 105535250 A CN105535250 A CN 105535250A CN 201610045922 A CN201610045922 A CN 201610045922A CN 105535250 A CN105535250 A CN 105535250A
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preparation
drug
anesthesia
parts
drug anesthesia
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唐国萍
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention belongs to the technical field of medicines, and relates to a drug anesthesia preparation and a preparation method and application thereof. For the defects in the prior art, the drug anesthesia preparation is prepared from flos daturae, jasmine roots, folium artemisiae argyi, agrimonia pilosa ledeb, aspongopus chinensis dallas and inula flowers. The drug anesthesia preparation has quite good anesthesia and analgesia effects on the aspect of anesthesia, is low in medicine side effect and high in patient satisfaction degree, and has remarkable clinical popularization value.

Description

A kind of drug anesthesia preparation and its production and use
Technical field
The invention belongs to medical art, be specifically related to a kind of drug anesthesia preparation and its production and use.
Background technology
Anesthesia be when performing a surgical operation or be eliminate pain when carrying out diagnostic test operation, ensure patient safety, create the various methods that good surgical condition takes, mainly comprise general anesthesia, local anesthesia and combined anesthesia.In the process of ultrasonic scaling, in clean facing and periodontal pocket, the pessimal stimulation thing such as bacterial plaque, tartar, tartar, calculus, can cause patient teeth and periodontal soft tissue to occur the pain that degree is different.Especially gerontal patient, Periodontal Status is generally not good enough, occurs gingival atrophy, Root exposnre, odontoseisis and the situation such as tooth severe dental attrition and wedge shaped defect, more easily the insufferable pain of patient occurs, brings certain misery and mental pressure to patient.
In the use procedure of Chinese drug anesthesia medicine, although played important effect clinically in the department of stomatology, larynx section etc., but still have that types of drugs is few, prescription change is little; Modern clinical research is few, and using method is single; Clinical study design is strict, lacks the shortcoming and defect that strict contrast etc. is a little.Therefore, in conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, reducing the angle of side effect, study and carry out to Chinese medicine ingredients the preparation that screening is extracted and/or compatibility is obtained, its side effect is little, and safety is high, and advantage is remarkable.
Summary of the invention
In order to overcome prior art deficiency, the invention provides a kind of drug anesthesia preparation, this drug anesthesia preparation good effect, side effect is little, patient satisfaction is high, and it is obtained by following Six-element crude drug: Flos Daturae, Radix Jasmini Sambac, Folium Artemisiae Argyi, Herba Agrimoniae, Aspongopus, Flos Inulae.
Further, in this drug anesthesia preparation recipe, the function of each medicine cures mainly, as follows:
Flos Daturae, pungent, temperature; Poisonous.Return lung, Liver Channel.Antiasthmatic-antitussive, analgesia, spasmolytic.For asthma and cough, coldness and pain in the epigastrium, rheumatic arthralgia, children's's intermittent infantile convulsion; Surgical anesthesia.
Radix Jasmini Sambac, bitter, temperature, poisonous.Anesthesia, pain relieving.Control to fall and damage muscles and bones, dental caries, headache, insomnia.
Folium Artemisiae Argyi, pungent, bitter, temperature; Slightly poisonous.Return liver,spleen,kidney warp.Dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage; External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficient cold type.
Herba Agrimoniae is bitter, puckery, flat.GUIXIN, Liver Channel.Astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.
Aspongopus, salty, temperature.Return liver,spleen,kidney warp.Regulating QI to relieve pain, warming middle-JIAO is supporing yang.For cold syndrome of the stomach distending pain, stomachache due to hyperactive liver-QI attacking the stomach, impotence due to deficiency of the kidney, soreness of waist and knee joint.
Flos Inulae, bitter, pungent, salty, tepor.Return lung, spleen, stomach, large intestine channel.Sending down the abnormal ascending QI, expectorant, row water, preventing or arresting vomiting.For cough due to wind and cold, phlegm retention stores knot, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum, vomiting eructation, epigastric oppression and rigidity.
After drug anesthesia formulation compositions of the present invention, there is significant analgesia, anaesthetic effect.The parts by weight of the present invention to above-mentioned all taste Chinese medicine carry out preferably, preferred condition be after drug matching uses medicine to the enhancing of anesthesia procedures effect.Preferably, drug anesthesia preparation of the present invention is obtained by the crude drug of following weight portion: Flos Daturae 7-18 part, Radix Jasmini Sambac 5-10 part, Folium Artemisiae Argyi 6-12 part, Herba Agrimoniae 8-15 part, Aspongopus 5-8 part, Flos Inulae 5-8 part.As a preferred embodiment of the present invention, drug anesthesia preparation master of the present invention is obtained by the crude drug of following weight portion: Flos Daturae 12 parts, Radix Jasmini Sambac 8 parts, Folium Artemisiae Argyi 9 parts, Herba Agrimoniae 11 parts, Aspongopus 7 parts, Flos Inulae 6 parts.
In order to express drug anesthesia preparation of the present invention better, drug anesthesia preparation of the present invention can be prepared into dosage form conventional clinically.Such as, external preparation.Preferably, drug anesthesia preparation of the present invention conveniently preparation technology be prepared into powder, water preparation or unguentum.
Present invention also offers a kind of preparation method of said medicine preparation for callouse, it mainly comprises following step: get above-mentioned traditional Chinese medicine powder and be broken into coarse powder, with 30% alcohol reflux secondary, each 1 hour, merge extractive liquid, filtered, filtrate recycling ethanol containing crude drug 2g to every 1ml, adds ethanol and makes alcohol content reach 75%, leaves standstill 24 hours, filter, filtrate recycling ethanol containing crude drug 4g, adds water to 8 times amount, cold preservation 48 hours to every 1ml, filter, filtrate concentrates and get final product; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically, as powder, water preparation or unguentum etc. in this preparation method.
The present invention also asks to protect the purposes of said medicine preparation for callouse in the ultrasonic scaling anaesthetic of preparation.The display of pharmacodynamics test example, compares with matched group, and drug anesthesia preparation analgesic effect of the present invention is obviously good than each group of contrast, and the satisfaction of patient is obviously better than contrasting each group, and between group, comparing difference is very remarkable.
In a word, drug anesthesia preparation of the present invention, in analgesia, anesthesia, compared with prior art has following advantage:
1) compared with positive control drug and the random matched group changing prescription, drug anesthesia preparation of Chinese medicine composition of the present invention eases pain, anaesthetic effect is more remarkable, this shows that each component of Chinese medicine of the present invention has significant synergism, significantly can improve the symptom of patient, improves satisfaction.
2) compared with current chemotherapeutic agent, drug anesthesia preparation of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and drug anesthesia preparation of the present invention effect is comprehensive, medication effect is better, significantly improve the compliance of patient, and improve the quality of life of patient.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.
Embodiment 1-6 powder
Table 1 prescription
The various embodiments described above preparation method: get each medical material in compositions, conveniently technique grinds to form powdery, cross 100 mesh sieves, little fire drying is for subsequent use, obtains powder.During use, disinfecting cotton swab dips in smears periodontal, clear water cleaning down after 3 ~ 5min a little back and forth, then carries out ultrasonic scaling treatment.
Embodiment 7-12 water preparation
Table 2 prescription
The various embodiments described above preparation method: get each medical material in prescription, conveniently decocting for Chinese herbal medicine technological operation, filtering medicinal residues and get final product.When this water preparation is used for ultrasonic scaling, disinfecting cotton swab dips in a little medicinal liquid and smears periodontal back and forth, uses clear water cleaning down, then treat after 3 ~ 5min.
Embodiment 13-16, comparative example 1-2 unguentum
Table 3 prescription
The various embodiments described above preparation method: get above-mentioned traditional Chinese medicine powder and be broken into coarse powder, with 30% alcohol reflux secondary, each 1 hour, merge extractive liquid, filters, and filtrate recycling ethanol contains crude drug 2g to every 1ml, adding ethanol makes alcohol content reach 75%, leave standstill 24 hours, filter, filtrate recycling ethanol contains crude drug 4g to every 1ml, add water to 8 times amount, cold preservation 48 hours, filters, namely obtains Chinese medical concrete after filtrate concentrate drying; By Chinese medical concrete drying, pulverize and make dried cream powder, add customary adjuvant components utilising prior art and be prepared into unguentum.During use, disinfecting cotton swab dips in a little ointment uniform application periodontal, and then clear water cleaning down after 2 ~ 3min carries out ultrasonic scaling treatment.
Pharmacodynamics test: drug anesthesia preparation clinical treatment situation of the present invention is observed
1. general clinical data:
Between in January, 2009 to 2011 year December, be willing to old scaling person 200 example of received treatment of Chinese herbs at outpatient clinic.Be divided into treatment group, matched group, contrast I group and contrast II group at random, often organize 50 routine patients.
Wherein, the treatment group age between 55 ~ 79 years old, 58.9 years old mean age.The matched group age between 54 ~ 79 years old, 58.6 years old mean age.Contrast I group of age between 55 ~ 76 years old, 58.1 years old mean age.Contrast II group of age between 54 ~ 79 years old, 58.0 years old mean age.Four groups of patients carry out the general clinical data such as age and sex and compare without significant difference, there is comparability (P > 0.05).
2. therapeutic scheme:
Treatment group: disinfecting cotton swab dips in the ointment uniform application periodontal of a little embodiment 13 preparation, and clear water cleaning down after 2 ~ 3min, then carries out ultrasonic scaling treatment.
Matched group: use cotton balls ethanol (75%) to be carried out the partial smearing of periodontal, enter thorough cleaning with clear water after 2 ~ 3min, then come into effect ultrasonic scaling.
Contrast I group: disinfecting cotton swab dips in the ointment uniform application periodontal of a little comparative example 1 preparation, and clear water cleaning down after 2 ~ 3min, then carries out ultrasonic scaling treatment.
Contrast II group: disinfecting cotton swab dips in the ointment uniform application periodontal of a little comparative example 2 preparation, and clear water cleaning down after 2 ~ 3min, then carries out ultrasonic scaling treatment.
3. analgesic effect:
Analgesic effect is evaluated in the mode of scoring.
0 point: without pain, without uncomfortable sensation in patient treatment procedure;
1 point: mild pain or discomfort, but patient can partner treatment;
2 points: moderate pain, patient pain is comparatively obvious, need interrupt or intermittent treatment;
3 points: severe pain, patient's extreme pain, or can not refuse treatment.
4. statistical method:
This group total data uses SPSS20.0 software kit to carry out date processing.Enumeration data compares employing X 2inspection, meter data adopts ( represent, compare between group and adopt t inspection, represent that difference has statistical significance with P < 0.05.
5. therapeutic outcome:
Four groups specifically ease pain, anaesthetize results contrast, in table 4.
Table 4 eases pain, Comparison (dividing)
n 0 1 2 3
Treatment group 50 48 2 0 0
Matched group 50 0 13 26 11
Contrast I group 50 21 14 10 5
Contrast II group 50 15 13 15 7
In this research, the data of table 4 can show: treatment group is after employing drug anesthesia preparation, analgesia, anaesthetic effect are obviously good than each group of contrast, the satisfaction of patient is obviously better than contrasting each group, between group, comparing difference is very remarkable, has statistical significance (P < 0.05); Specifically, the clinical effectiveness for the treatment of group and contrast I, II group shows, changes prescription and/or proportioning, can not reach the same excellent therapeutic effect of drug anesthesia preparation of the present invention; Meanwhile, contrast without significant difference between each group, not statistically significant (P > 0.05).This shows in ultrasonic scaling procedure, and according to clinical symptoms and the concrete condition of patient, this herbal anesthetic fully, effectively can alleviate the misery of patient, has remarkable anaesthetic effect and analgesic effect, improves the satisfaction of patient, can be used for clinical application.
More than describe the preferred embodiment of the present invention in detail; but the present invention is not limited to the detail in above-mentioned embodiment, within the scope of technical conceive of the present invention; can carry out multiple simple variant to technical scheme of the present invention, these simple variant all belong to protection scope of the present invention.
It should be noted that in addition, each concrete technical characteristic described in above-mentioned detailed description of the invention, in reconcilable situation, can be combined by any suitable mode, in order to avoid unnecessary repetition, the present invention illustrates no longer separately to various possible compound mode.
In addition, also can carry out combination in any between various different embodiment of the present invention, as long as it is without prejudice to thought of the present invention, it should be considered as content disclosed in this invention equally.

Claims (6)

1. a drug anesthesia preparation, is characterized in that, it is obtained by the crude drug of following weight portion: Flos Daturae 7-18 part, Radix Jasmini Sambac 5-10 part, Folium Artemisiae Argyi 6-12 part, Herba Agrimoniae 8-15 part, Aspongopus 5-8 part, Flos Inulae 5-8 part.
2. drug anesthesia preparation drug anesthesia preparation as claimed in claim 1, it is characterized in that, it is obtained by the crude drug of following weight portion: Flos Daturae 12 parts, Radix Jasmini Sambac 8 parts, Folium Artemisiae Argyi 9 parts, Herba Agrimoniae 11 parts, Aspongopus 7 parts, Flos Inulae 6 parts.
3. the drug anesthesia preparation as described in claim 1,2, is characterized in that, it is external preparation.
4. the drug anesthesia preparation as described in claim 1,2, is characterized in that, it is powder, water preparation or unguentum.
5. prepare a method for Chinese drug anesthesia as claimed in claim 4, it is characterized in that, it comprises the following steps: get above-mentioned traditional Chinese medicine powder and be broken into coarse powder, with 30% alcohol reflux secondary, each 1 hour, merge extractive liquid, filter, filtrate recycling ethanol containing crude drug 2g to every 1ml, adds ethanol and makes alcohol content reach 75%, leave standstill 24 hours, filter, filtrate recycling ethanol contains crude drug 4g to every 1ml, add water to 8 times amount, cold preservation 48 hours, filter, filtrate concentrates and get final product.
6. the drug anesthesia preparation as described in claim 1,2 is purposes in the ultrasonic scaling anaesthetic of preparation.
CN201610045922.3A 2016-01-25 2016-01-25 Drug anesthesia preparation and preparation method and application thereof Withdrawn CN105535250A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103705791A (en) * 2014-01-14 2014-04-09 朱洪远 Medicament for clinical anesthesia and preparation method thereof
CN104721632A (en) * 2015-04-15 2015-06-24 晁东辉 Clinical medical herbal anesthetic
CN104758465A (en) * 2015-04-15 2015-07-08 曹元智 Traditional Chinese medicine for tooth extraction anesthesia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103705791A (en) * 2014-01-14 2014-04-09 朱洪远 Medicament for clinical anesthesia and preparation method thereof
CN104721632A (en) * 2015-04-15 2015-06-24 晁东辉 Clinical medical herbal anesthetic
CN104758465A (en) * 2015-04-15 2015-07-08 曹元智 Traditional Chinese medicine for tooth extraction anesthesia

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Application publication date: 20160504