CN105534725B - A kind of comprehensive function type toothpaste containing nanometer diamond alkene - Google Patents

A kind of comprehensive function type toothpaste containing nanometer diamond alkene Download PDF

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Publication number
CN105534725B
CN105534725B CN201511010873.1A CN201511010873A CN105534725B CN 105534725 B CN105534725 B CN 105534725B CN 201511010873 A CN201511010873 A CN 201511010873A CN 105534725 B CN105534725 B CN 105534725B
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diamond alkene
nanometer diamond
function type
type toothpaste
comprehensive function
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CN105534725A (en
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郭留希
赵清国
何本锋
刘永奇
杨晋中
张建华
武艳强
邵静茹
穆小娜
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Zhengzhou Synthetic Diamond and Products Engineering Technology Research Center Co Ltd
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Zhengzhou Synthetic Diamond and Products Engineering Technology Research Center Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

Abstract

The invention discloses a kind of comprehensive function type toothpaste containing nanometer diamond alkene, belong to oral hygiene and healthcare field, which is prepared by the raw material of following weight percentage：Nanometer diamond alkene 0.5% ~ 1%, rubbing agent 15% ~ 50%, p-hydroxybenzoate 0.1% ~ 0.3%, hydroxyethyl cellulose 1.5% ~ 2.5%, sanlose 1% ~ 1.5%, strontium chloride 0.6% ~ 1.5%, aurantiin 1.0% ~ 3.0%, compound Chlorhexidine 0.01% ~ 0.05%, thickener 2% ~ 5%, sweetener 0.03% ~ 0.1%, preservative 0.05% ~ 0.1%, wetting agent 20% ~ 25%, lauryl sodium sulfate 1% ~ 4%, surplus are deionized water.Nanometer diamond alkene is with the addition of in integrated function type toothpaste provided by the invention, integrated function type toothpaste can handle a variety of oral problems simultaneously, and the with obvious effects and duration is long；The method that integrated function type toothpaste can substitute other treatment mouth disease to a certain extent reduces the maintenance cost in oral cavity.

Description

A kind of comprehensive function type toothpaste containing nanometer diamond alkene
Technical field
The invention belongs to oral hygienes and healthcare field, and in particular to a kind of comprehensive function type tooth containing nanometer diamond alkene Cream.
Background technology
The health status in oral cavity is to reflect the mirror of life and health, but modern life rhythm is fast, and operating pressure is big, For other diseases such as such as heart disease, hypertension that compare, oral health issue is said by people to be ignored or even has among the people The wrong saying of " toothache is not disease ".Oral health focuses on removing swill and dirt, and control bacterium colony enhances physiology It stimulates, makes the good environment of oral cavity and dentognathic system there are one cleaning health.
Toothpaste is the most important cleaning supplies that oral hygiene health is used in daily life.With continually developing for new material With the continuous improvement of technological level, various types of toothpaste are also come out one after another, and diversified trend also occurs in function.In numerous teeth In cream species, medicated toothpaste is very big in the usage amount of China, and not only possessing plays the role of toothpaste, also the temperature with Chinese herbal medicine With property and effect, can play and dispel implication, anti-inflammation and sterilization and it is clearing heat and detoxicating the effects that.
All medicated toothpaste is all among some medicinal herb components or its extract are mixed into toothpaste, to pass through brush at present Tooth and the process gargled carry out hygiene care to oral cavity.Although Chinese herbal toothpaste property is mild, can bactericidal antiphlogistic etc., deposit In the following shortcoming：
1st, in the toothpaste containing drug ingedient, since powder particle thickness is uneven, it is difficult to the other components in toothpaste Effectively uniformly mixing, the result is that more difficult come into full contact with oral cavity tissue and reduce actual efficacy.
2nd, in drug containing formulation of tooth-paste, although can be uniformly mixed in formulation of tooth-paste, this mixing is also only Physical mixed, in practice as the quick processes such as brush teeth and gargle are brought away from oral environment, drug ingedient is deposited in the oral cavity It stays the time short and drug effect can not be released effectively.These drug ingedients can generate centainly after being mixed together with the other ingredients of toothpaste The physical reaction of degree, the original effect of drug ingedient decrease due to these are reacted, so as to reduce drug on the whole Therapeutic effect.
The content of the invention
It is an object of the invention to provide a kind of good comprehensive function type toothpaste containing nanometer diamond alkene of using effect.
Based on above-mentioned purpose, the present invention uses following technical scheme：A kind of comprehensive function type tooth containing nanometer diamond alkene Cream is prepared by the raw material of following weight percentage：Nanometer diamond alkene 0.5% ~ 1%, rubbing agent 15% ~ 50%, para hydroxybenzene first Acid esters 0.1% ~ 0.3%, hydroxyethyl cellulose 1.5% ~ 2.5%, sanlose 1% ~ 1.5%, strontium chloride 0.6% ~ 1.5%, Aurantiin 1.0% ~ 3.0%, compound Chlorhexidine 0.01% ~ 0.05%, thickener 2% ~ 5%, sweetener 0.03% ~ 0.1%, preservative 0.05% ~ 0.1%, wetting agent 20% ~ 25%, lauryl sodium sulfate 1% ~ 4%, surplus are deionized water.
Further, the nanometer diamond alkene is lamellar mono-crystalline structures, is sp between the carbon atom of same lamella3Track Hydridization carbon key connection is sp between carbon atom between layers2Hydridization carbon key connection, C content are 99~100%, spacing of lattice For 0.21nm；Grain size is R, 20≤R≤500nm.
Further, through surface-functionalized processing, processing procedure is the nanometer diamond alkene：Nanometer diamond alkene is placed in matter Amount is than being 1 ︰（2~5）Dense HNO3/ dense H2SO4Mixed liquor in, be heated to reflux at 90 DEG C for 24 hours after centrifugation；Taking precipitate is used It is 5.0 ~ 6.0 that deionized water, which is washed to cleaning solution pH,；Again with 0.1 ~ 0.5molL-1Na2SiO3Aqueous solution is washed to cleaning solution PH is 7.0 ~ 7.5, carries out ultrasonic disperse while washing, drying is finally washed with deionized.
Further, the rubbing agent is pressed by two water salt of calcium monohydrogen phosphate and calcium monohydrogen phosphate anhydrous salt（7~9）The ratio of ︰ 1 is mixed It closes.
Further, the preservative is one or both of sorbic acid and sorbate.
The above-mentioned comprehensive function type toothpaste containing nanometer diamond alkene is prepared according to procedure below：
（1）Nanometer diamond alkene, strontium chloride, aurantiin, compound chlorhexidine and part thickener are being shaken using deionized water It swings and is sufficiently mixed in machine uniformly, prevent from precipitating；
（2）Rubbing agent, p-hydroxybenzoate, sanlose, sweetener and hydroxyethyl cellulose are dissolved In remaining deionized water, add wetting agent and thickener adjusts the humidity and viscosity of material, prevent toothpaste component from drying Cure；
（3）By step（1）And step（2）In obtained material be sufficiently mixed, add in remaining thickener, preservative and ten Degassing process is carried out up to lotion of toothpaste after mixer high speed stirs evenly after sodium dialkyl sulfate.
Comprehensive function type toothpaste provided by the invention has the following advantages：
（1）Strontium chloride can be absorbed by dentinal tubule and generate osteoid product strontium carbonate, carbonic acid in the present invention Strontium, which is deposited at dentinal tubule mouth, blocks external substance entrance.Aurantiin is a kind of Flavonoid substances, has higher sterilizing Inflammation-diminishing function plays the function except halitosis in toothpaste.Compound Chlorhexidine is a kind of canker sore repair medicine ingredient.
（2）Nanometer diamond alkene has high-specific surface area and very strong adsorption capacity in itself, by surface-functionalized and active It after change processing, can increase the active site on nanometer diamond alkene surface, further increase the adsorption energy of nanometer diamond alkene Power, and nanometer diamond alkene is made to possess the characteristics of selective absorption.The drug ingedients such as strontium chloride, aurantiin and compound chlorhexidine are born It is loaded on nanometer diamond alkene, strontium chloride enters with nanometer diamond alkene at the dentinal tubule mouth on tooth during brushing teeth, and bears The hydroxyapatite effect generation hydroxyl saamite of the strontium chloride and dentine that are loaded in nanometer diamond alkene surface increases afterwards The volume of nanometer diamond alkene blocks external substance and enters dentinal tubule moderate stimulation tooth god so as to be loaded with dentinal tubule Through；Meanwhile nanometer diamond alkene its surface-active by surface-functionalized processing is higher, but internal structure is still stable Diamond structures, the nanometer diamond alkene by surface-functionalized processing can not only carry drug ingedient and be applied to oral cavity tissue area Domain, and will not decomposition be corroded by complicated oral cavity materialization environment；The then shape between layers of nanometer diamond alkene layer structure Into " cavernous body " structure of drug molecule, drug ingedient reaches regular point in stratiform " cavernous body " structure of diamond alkene Cloth is stored (see Fig. 1), and can play the role of sustained release, considerably increases the residence time of drug ingedient in the oral cavity, is risen The effect of sustainable protection oral hygiene is arrived.
（3）The present invention uses nanometer diamond alkene as raw material, and nanometer diamond alkene hardness is high, wearability is good, can be effectively clear Except the stain of dental surface；Meanwhile the particle of nanometer diamond alkene is superfine, and comprehensive polishing, and energy can be carried out to tooth It is enough that effective " polishing " is carried out to tooth, oral cavity spot is avoided to be attached to dental surface.In addition, nanometer diamond alkene is pure carbon object Matter has good biocompatibility, and biological rejection reaction will not be generated to gum and other oral cavity tissues, and can be discharged In vitro.
（4）Nanometer diamond alkene, integrated function type toothpaste energy are with the addition of in integrated function type toothpaste provided by the invention Enough to handle a variety of oral problems simultaneously, the with obvious effects and duration is long；Integrated function type toothpaste can replace to a certain extent For the method for other treatment mouth disease, the maintenance cost in oral cavity is reduced.By surface-functionalized nanometer diamond alkene not only It can carry more drug ingedients, and since it with nano-scale and strong absorption property can then be firmly attached to oral cavity In and be easily detected by gargling or diet and be brought away from oral environment, while the sponge structure of its interlayer can it is continual to Entrained drug ingedient is sustained in oral environment, has thus achieved the purpose that lasting to safeguard oral health.
Description of the drawings
Fig. 1 is state diagram of the different pharmaceutical component in nanometer diamond alkene.
Specific embodiment
With reference to embodiment, the present invention is described in detail.
The preparation of 1 nanometer diamond alkene of embodiment
Nanometer diamond alkene is prepared using following methods：
（1）It is preliminary broken：Diamond raw material is sent into the particle for crushing and sifting out more than 70 mesh in ball milling shaping barrel, when crushing Between for 1-5h, the coarse fodder below 70 mesh returns to ball milling shaping barrel and is crushed again；Particle screens out 800 mesh through multistage vibrating sieving machine Above fines, sieve time of shaking are 30min-2h, which repeats more than sieving once；
（2）It crushes again：800 mesh more than fineves will be screened out to be delivered in air-flow crusher, using high pressure draught to thin Fine powders more than 8000 mesh is screened out after feed powder is broken, residue on sieve Returning flow crusher is crushed again；
（3）Pickling：Fine powders more than 8000 mesh is placed in the concentrated sulfuric acid and 2 ~ 7h of pickling, mistake in concentrated nitric acid mixed liquor first Filter, cleaning, the concentrated sulfuric acid and concentrated nitric acid mixed liquor by mass fraction be 98% concentrated sulfuric acid and mass fraction be 10% concentrated nitric acid by It is 5 according to mass ratio:1 mixes；Then by fine powder be placed in 140 DEG C ~ 160 DEG C mass fractions be 5% ~ 8% dilute hydrochloric acid in 4 ~ 9h, Filtering；The fine powder is placed in 10 ~ 20 h in hydrofluoric acid again, remove the metal impurities in material and is crushed in ball milling shaping, air-flow Then the impurity being attached in the process on material is cleaned using deionized water to cleaning solution pH close to 7；
（4）Sorting：Material after cleaning is centrifuged, supernatant liquid is taken to carry out 1-5 days precipitations and is sorted, in removal Layer clear liquid, gets product nanometer diamond alkene after lower sediment thing is dried；In step with centrifugal separation, centrifugation time 30min- 2h, rotating speed 8000rpm-15000rpm.
Nanometer diamond alkene is prepared as lamellar mono-crystalline structures, is sp between the carbon atom of same lamella3Orbital hybridization carbon Key connection is sp between carbon atom between layers2Hydridization carbon key connection, C content are 99~100%, and spacing of lattice is 0.21nm；Grain size is R, 20≤R≤500nm.
The nanometer diamond alkene that embodiment 2-8 is prepared using embodiment 1 is as raw material.
Embodiment 2
A kind of comprehensive function type toothpaste containing nanometer diamond alkene, is prepared by the raw material of following weight percentage：It receives Rice diamond alkene（Without surface-functionalized processing）0.7%th, rubbing agent 40%, p-hydroxybenzoate 0.15%, hydroxy ethyl fiber Element 2%, sanlose 1.2%, strontium chloride 1.2%, aurantiin 3.0%, compound Chlorhexidine 0.04%, thickener 3.5%, sweet tea Taste agent 0.05%, preservative 0.08%, wetting agent 22%, lauryl sodium sulfate 2.5%, surplus are deionized water.
The above-mentioned comprehensive function type toothpaste containing nanometer diamond alkene is prepared according to procedure below：
（1）Nanometer diamond alkene, strontium chloride, aurantiin, compound chlorhexidine and part thickener are being shaken using deionized water It swings and is sufficiently mixed in machine uniformly, prevent from precipitating；
（2）Rubbing agent, p-hydroxybenzoate, sanlose, sweetener and hydroxyethyl cellulose are dissolved In remaining deionized water, add wetting agent and thickener adjusts the humidity and viscosity of material, prevent toothpaste component from drying Cure；
（3）By step（1）And step（2）In obtained material be sufficiently mixed, add in remaining thickener, preservative and ten It is stirred for carrying out degassing process after sodium dialkyl sulfate after machine high speed stirs evenly up to lotion of toothpaste.
Embodiment 3
Embodiment 3 and embodiment 2 the difference is that：Embodiment 3 uses the nanometer diamond through surface-functionalized processing Alkene prepares comprehensive function type toothpaste.Specially：A kind of comprehensive function type toothpaste containing nanometer diamond alkene, by following weight percentage The raw material of ratio is prepared：Nanometer diamond alkene 0.7%, rubbing agent 40%, p-hydroxybenzoate by surface-functionalized processing 0.15%th, hydroxyethyl cellulose 2%, sanlose 1.2%, strontium chloride 1.2%, aurantiin 3.0%, compound Chlorhexidine 0.04%th, thickener 3.5%, sweetener 0.05%, preservative 0.08%, wetting agent 22%, lauryl sodium sulfate 2.5%, surplus are Deionized water.
Through surface-functionalized processing, processing procedure is the nanometer diamond alkene：Nanometer diamond alkene is placed in mass ratio as 1 ︰ 2 Dense HNO3/ dense H2SO4Mixed liquor in, 90 DEG C be heated to reflux for 24 hours after centrifugation；Taking precipitate be washed with deionized to Cleaning solution pH is 5.0 ~ 6.0；0.2molL is used again-1Na2SiO3It is 7.0 ~ 7.5 that aqueous solution, which is washed to cleaning solution pH, is being washed While carry out ultrasonic disperse, drying is finally washed with deionized.
The above-mentioned comprehensive function type toothpaste containing nanometer diamond alkene is prepared according to following steps：
（1）Using deionized water by nanometer diamond alkene, strontium chloride, aurantiin, the compound chlorine Jing Guo surface-functionalized processing Determined and part thickener earthquake machine in be sufficiently mixed uniformly, prevent from precipitating；
（2）Rubbing agent, p-hydroxybenzoate, sanlose, sweetener and hydroxyethyl cellulose are dissolved In remaining deionized water, add wetting agent and thickener adjusts the humidity and viscosity of material, prevent toothpaste component from drying Cure；
（3）By step（1）And step（2）In obtained material be sufficiently mixed, add in remaining thickener, preservative and ten It is stirred for carrying out degassing process after sodium dialkyl sulfate after machine high speed stirs evenly up to lotion of toothpaste.
Embodiment 4-8
Weight percent and remarks section according to the raw material given by table 1 prepare being bored containing nanometer for embodiment 4-8 The comprehensive function type toothpaste of stone alkene.Embodiment 4-8 uses the nanometer diamond alkene through surface-functionalized processing.
The preparation method reference implementation example 3 for the comprehensive function type toothpaste containing nanometer diamond alkene that embodiment 4-8 is provided, The difference is that dense HNO in the surface-functionalized processing procedure of nanometer diamond alkene3With dense H2SO4Mass ratio, Na2SiO3It is water-soluble The concentration of liquid is different, and concrete outcome is shown in Table 2.
Remarks：Sorbic acid is used as preservative in embodiment 4-5 and comparative example 1, two water salt of calcium monohydrogen phosphate and calcium monohydrogen phosphate Anhydrous salt presses 7：1 ratio is mixed with rubbing agent；Embodiment 6-7 uses sorbate as preservative, two water salt of calcium monohydrogen phosphate 8 are pressed with calcium monohydrogen phosphate anhydrous salt：1 ratio is mixed with rubbing agent；Embodiment 8 is using sorbic acid and the mixture of sorbate For preservative, two water salt of calcium monohydrogen phosphate and calcium monohydrogen phosphate anhydrous salt press 9：1 ratio is mixed with rubbing agent.
Comparative example 1
Ratio according to each raw material of the comparative example 1 provided in table 1 prepares toothpaste, wherein not adding by surface-functionalized The nanometer diamond alkene of processing, its preparation method reference implementation example 2.
1 antiallergy of effect test is tested
Artificial egg's shell test material as a comparison is selected, is used after certain spotization processing is carried out to its surface.
The reason for selecting artificial egg's shell is as follows：1st, the composition of tooth and egg shell is all and the egg shell based on calcium salt It is approached with the Mohs' hardness of tooth, the former Mohs' hardness is 3.5 ~ 5, and the latter's Mohs' hardness is 4.5 ~ 6.5；2nd, the tooth sheet of tooth Matter surface is thick with many exposed dentinal tubules, and at 2.5 μm or so, the stomata on egg shell surface is straight in the aperture of these tubules Footpath scope is at 1.5 ~ 2.5 μm；3rd, acetic acid is that a kind of food acids, and to egg shell and dentine are touched in life It is all corrosive, is simulated using the environment of the very much like physical characteristics of dentin surface and egg surface and acetic acid in anti-toothpaste Desensitizer is with the anti-allergic effects to tooth.
It takes the artificial egg's shell handled through surface blotization and is divided into four groups, every group has 5 parallel tests, respectively using real Apply example 2（Nano diamond alkene is used as raw material）, embodiment 3（Use the nanometer diamond alkene Jing Guo surface-functionalized processing for Raw material）, embodiment 4（The nanometer diamond alkene Jing Guo surface-functionalized processing is used as raw material）With comparative example 1（It is added without nanometer brill Stone alkene）The toothpaste of preparation carries out four groups of samples the friction treatment of same number in same time t, is corresponding in turn to, remembers respectively For 1 group of experiment, 2 groups of experiment, 3 groups of experiment, 4 groups of experiment；It is then placed in after being impregnated in certain density acetum and is struck It hits, eggshell is tapped until its breakage using the same dynamics that taps, and count number of taps, every group of experiment takes final result Average value, concrete outcome is shown in Table 3.
From the results shown in Table 3,1 group is tested, 2 groups of experiment and the breakage that is averaged of 3 groups of processed egg shells of experiment strike Number is hit higher than 4 groups of experiment, this explanation has better antiallergic effect containing toothpaste provided by the invention；With nanometer diamond Alkene content raises, antiallergic effect enhancing.Meanwhile as processing extends processing time, the average damaged percussion of each test group Number is consequently increased, but tests 4 groups（It is added without nanometer diamond alkene）Antiallergic effect it is increased not apparent enough, explanation is received Rice diamond alkene has preferable slow release effect, can drug desensitization ingredient be discharged into pathological area so as to improve antiallergic effect.
Meanwhile it was found from 1 group of comparing result with testing 2 groups of experiment, after carrying out functionalization to nanometer diamond alkene, The active site on nanometer diamond alkene surface increases, and the active ingredient of load increases, and the antiallergic effect of toothpaste can be remarkably reinforced.
2 whitening of effect test and bactericidal effect
Commercially available porcelain tooth surface is handled（With a diameter of 10 μm of iron wire brush, 50 frictions, make its surface repeatedly Roughness it is identical, convenient for the attachment of subsequent step bacterium and fouling product）, it is then immersed in dirty water and impregnates, makes its surface A certain number of bacteriums are grown while spot.By treated, baking-ceramic tooth is divided into four groups, and every group of 5 parallel tests are distinguished Using 2（Nano diamond alkene is used as raw material）, embodiment 3（Use the nanometer diamond alkene Jing Guo surface-functionalized processing for Raw material）With comparative example 1（It is added without nanometer diamond alkene）The toothpaste of preparation is handled, and is corresponding in turn to, be denoted as respectively experiment 5 groups, 6 groups and 7 groups of experiment are tested, record baking-ceramic tooth improves time during 3 color ranges, and detects bacteria containing amount on baking-ceramic tooth, result of the test It is shown in Table 4.
From the result of the test of table 4 can be seen that experiment 5 groups and test 6 groups in used the identical color range of baking-ceramic tooth raising Time significantly lower than 7 groups of time of experiment, illustrate that nanometer diamond alkene is added in toothpaste can improve whitening effect.Meanwhile It tests baking-ceramic tooth surface colony in 5 groups and 6 groups of experiment and reduces quantity apparently higher than testing 7 groups, bacterium colony recovers needed for previous level The time wanted higher than 7 groups of experiment, this is because nanometer diamond alkene has slow releasing function, can effectively inhibit bacterium colony and continue to grow.
In addition, it was found from 5 groups of Comparative results with testing 6 groups of experiment, by the slow of surface-functionalized nanometer diamond alkene The effect released, which is higher than, without surface-functionalized nanometer diamond alkene, uses surface-functionalized nanometer diamond alkene to be prepared for raw material Toothpaste fungistatic effect it is relatively good.

Claims (4)

1. a kind of comprehensive function type toothpaste containing nanometer diamond alkene, which is characterized in that by the raw material system of following weight percentage It is standby to form：Nanometer diamond alkene 0.5% ~ 1%, rubbing agent 15% ~ 50%, p-hydroxybenzoate 0.1% ~ 0.3%, hydroxyethyl cellulose 1.5% ~ 2.5%, sanlose 1% ~ 1.5%, strontium chloride 0.6% ~ 1.5%, aurantiin 1.0% ~ 3.0%, compound Chlorhexidine 0.01% ~ 0.05%, thickener 2% ~ 5%, sweetener 0.03% ~ 0.1%, preservative 0.05% ~ 0.1%, wetting agent 20% ~ 25%, 12 Sodium alkyl sulfate 1% ~ 4%, surplus are deionized water；The nanometer diamond alkene is lamellar mono-crystalline structures, and the carbon of same lamella is former It is sp between son3Orbital hybridization carbon key connection is sp between carbon atom between layers2Hydridization carbon key connection, C content 99 ~100%, spacing of lattice 0.21nm；Grain size is R, 20≤R≤500nm.
2. the comprehensive function type toothpaste according to claim 1 containing nanometer diamond alkene, which is characterized in that the nanometer Diamond alkene carries out surface-functionalized processing, and process is：Through surface-functionalized processing, processing procedure is the nanometer diamond alkene： Nanometer diamond alkene is placed in mass ratio as 1 ︰（2~5）Dense HNO3/ dense H2SO4Mixed liquor in, it is heavy to be heated to reflux centrifuging afterwards for 24 hours It forms sediment；It is 5.0 ~ 6.0 that taking precipitate, which is washed with deionized to cleaning solution pH,；Again with 0.1 ~ 0.5molL-1Na2SiO3It is water-soluble It is 7.0 ~ 7.5 that liquid, which is washed to cleaning solution pH, carries out ultrasonic disperse while washing, drying is finally washed with deionized.
3. the comprehensive function type toothpaste according to claim 1 containing nanometer diamond alkene, which is characterized in that the rubbing agent It is pressed by two water salt of calcium monohydrogen phosphate and calcium monohydrogen phosphate anhydrous salt（7~9）The ratio of ︰ 1 mixes.
4. the comprehensive function type toothpaste according to claim 1 containing nanometer diamond alkene, which is characterized in that the preservative For one or both of sorbic acid and sorbate.
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