CN105521338A - Drop for preventing neonatal jaundice and preparation method of drop - Google Patents

Drop for preventing neonatal jaundice and preparation method of drop Download PDF

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CN105521338A
CN105521338A CN201610023123.6A CN201610023123A CN105521338A CN 105521338 A CN105521338 A CN 105521338A CN 201610023123 A CN201610023123 A CN 201610023123A CN 105521338 A CN105521338 A CN 105521338A
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drop
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rhizoma
radix
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王育新
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Abstract

The invention discloses a drop for preventing neonatal jaundice. The drop is prepared from the following major raw materials in parts by weight: 5-15 parts of polypodium buergerianum miq., 10-20 parts of franzenbach rhubarb root and rhizome, 3-9 parts of yam powder, 3-7 parts of apple, 1-5 parts of orange, 3-8 parts of eleocharis dulcis, 1-5 parts of broken pine pollen powder, 5-15 parts of Chinese sage herb, 4-10 parts of liquorice root, 2-6 parts of lalang grass rhizome, 1-5 parts of niter and 3-8 parts of honeysuckle. The drop disclosed by the invention is easily available in medicinal material source and low in cost; and since the most selected medicinal materials are mild in nature, the drop, when used for a long time, can avoid increased burden on economy and body of a user.

Description

A kind of drop preventing neonatal jaundice and preparation method thereof
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of drop and preparation method of preventing neonatal jaundice.
Background technology
Medically non-full moon (being born in 28 days) neonatal jaundice, be referred to as neonatal jaundice, neonatal jaundice refers to non-neonate, because bilirubin metabolism is abnormal, blood mesobilirubin level is caused to raise, and to come across skin, mucosa and sclera jaundice be the disease of feature, primary disease have physiological and pathologic point.Physiologic jaundice occurs after birth for 2 ~ 3 days, and within 4 ~ 6 days, peak, within 7 ~ 10 days, disappear, premature infant's persistent period is longer, apart from outside slight inappetence, without other clinical symptoms.If within latter 24 hours, namely occur jaundice raw, every day, serum bilirubin increased to over 5mg/dl or >0.5mg/dl per hour; Persistent period is long, and in term infant >2 week, premature infant >4 week does not still move back, even continue intensification increase the weight of repeat after disappearing or raw after just start to occur jaundice in thoughtful several weeks, be pathological jaundice.
The cause of disease: 1. bilirubin generates too much because too much erythrocytic destruction and enterohepatic circulation increase, and serum unconjugated bilirubin is raised.The common cause of disease has: erythrocytosis, extravascular hemolysis, isoimmunization haemolysis, infection, enterohepatic circulation increase, red blood cell enzyme defect, red cell morphology exception, hemoglobinopathy.2. liver bilirubin metabolism obstacle is due to hepatocyte picked-up and the hypofunction of conjugated bilirubin, and serum unconjugated bilirubin is raised.The common cause of disease has: anoxia and infection, Crigler-Najjar syndrome, Gilbert syndrome, Lucey-Driscoll syndrome, medicine (as sulfanilamide, Salicylate, indomethacin, the lanatoside third gradegrade C), CH.3. bile excretion obstacle hepatocyte excretion conjugated bilirubin obstacle or bile duct are obstructed, and can cause conjugated hyperbilirubinemia, but as impaired in accompanied hepatocyte function simultaneously, also can have the rising of unconjugated bilirubin.The common cause of disease has: neonatal hepatitis, congenital metabolic defect are sick, bile duct obstruction.
Clinical manifestation: 1. physiologic jaundice: the lighter is light yellowly confined to neck surface, or involves trunk, and sclera also can disappear after 2 ~ 3 days by xanthochromia, recovers normal to color of the leather on the 5th ~ 6th; Severe one jaundice can throughout whole body equally ahead, vomitus and cerebrospinal fluid etc. also can xanthochromia for up to more than 1 week, particularly indivedual premature infant may persist to 4 weeks, and its excrement is still yellow, without bilirubin in urine.2. jaundice color and luster: the lighter is shallow pattern, severe one color is comparatively dark, but thoroughly red in the ruddy Huang of skin.3. the general only patella ulnaris of trunk, sclera and extremity near-end is more common at jaundice position.4. neonate: ordinary circumstance is good, without anemia, liver spleen not enlargement liver function is normal, bilirubin encephalopathy does not occur.5. premature infant: physiologic jaundice is common compared with term infant, can omit delay and occur for 1 ~ 2 day, and jaundice degree is heavier to disappear also comparatively late, can be extended down to 2 ~ 4 weeks.
In the method for existing Chinese medicine prevention neonatal jaundice, Authorization Notice No. CN102935182B(application number 201210386542.8) patent discloses a kind of decoction for the treatment of neonatal jaundice, it is made up of the crude drug of following weight portion: Radix Glycyrrhizae 5-6, Folium Isatidis 5-6, Rhizoma Imperatae 6-7, Rhizoma Phragmitis 6-7, Flos Lonicerae 3-4, Rhizoma Bistortae 3-4, Rhizoma Atractylodis 2-3, Herba Ludwigiae Prostratae 2-3, CUIYUNCAO 1-2, water is appropriate.Authorization Notice No. CN103055300A(application number 201310052501.X) patent discloses a kind of Chinese medicine composition for the treatment of neonatal jaundice, it is characterized in that, with parts by weight, comprise following component: Herba Artemisiae Scopariae 5-7, Rhizoma Zingiberis 2-4, Radix Codonopsis 5-7, Rhizoma Atractylodis Macrocephalae 5-7, Poria 5-7, Fructus Evodiae 2-4, Pericarpium Citri Reticulatae 2-4, Radix Glycyrrhizae 2-4.
As can be seen here, Chinese medicine occupies very important status in prevention neonatal jaundice, but in patent documentation, is not specifically designed to the drop of prevention neonatal jaundice.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is the drop providing prevention neonatal jaundice, medical material medicine source of the present invention is easy to get, with low cost, selected medical material mostly be mild in medicine property and thing, the drop be prepared into combined by Chinese crude drug and fruit, and life-time service also can not increase the burden on economy and health to user.
Another object of the present invention is just to provide the preparation method of above-mentioned drop.
Technical scheme of the present invention is:
Prevent a drop for neonatal jaundice, take off the primary raw material stating weight proportion and be prepared from: a flag 5-15 part, Radix et Rhizoma Rhei Franzenbachii 10-20 part, Rhizoma Dioscoreae powder 3-9 part, Fructus Mali pumilae 3-7 part, Fructus Citri junoris 1-5 part, Corm Eleocharitis 3-8 part, breaking cellular wall Pollen Pini 1-5 part, Herba Salviae Chinensis 5-15 part, Radix Glycyrrhizae 4-10 part, Rhizoma Imperatae 2-6 part, Sal Nitri 1-5 part, Flos Lonicerae 3-8 part.
Prevent a drop for neonatal jaundice, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: a flag 8-13 part, Radix et Rhizoma Rhei Franzenbachii 13-18 part, Rhizoma Dioscoreae powder 5-7 part, Fructus Mali pumilae 4-6 part, Fructus Citri junoris 2-4 part, Corm Eleocharitis 4-7 part, breaking cellular wall Pollen Pini 2-4 part, Herba Salviae Chinensis 8-13 part, Radix Glycyrrhizae 6-8 part, Rhizoma Imperatae 3-5 part, Sal Nitri 2-4 part, Flos Lonicerae 4-7 part.
Prevent a drop for neonatal jaundice, more preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: 10 parts, flag, Radix et Rhizoma Rhei Franzenbachii 15 parts, Rhizoma Dioscoreae powder 6 parts, Fructus Mali pumilae 5 parts, Fructus Citri junoris 3 parts, Corm Eleocharitis 5.5 parts, breaking cellular wall Pollen Pini 3 parts, Herba Salviae Chinensis 10 parts, 7 parts, Radix Glycyrrhizae, Rhizoma Imperatae 4 parts, Sal Nitri 3 parts, Flos Lonicerae 5 parts.
The preparation method of above-mentioned drop, step is as follows:
(1) be placed in transparent container by Sal Nitri, the light salt brine adding 80-100 DEG C soaks 2-4 hour, and forging is crisp, and it is stand-by to grind to form smalls;
(2) by a flag soaking in rice vinegar 10-20 minute, dryouied by pot, get appropriate food oil and pour in pot, when surrounding plays cigarette, put into a soaked flag, stir-fry 2-6 minute repeatedly, and grinding to form smalls, to cross 80-120 mesh sieve stand-by;
(3) Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and Flos Lonicerae crude drug 2-4 yellow wine is doubly mixed thoroughly, soak 25-45 minute, take out soaked crude drug, be placed in marmite, decoct with water 2 times, each amount of water is 2-4 times of crude drug, each decoction 50-70 minute, filter, twice filtrate merges to obtain mixed liquor;
(4) Fructus Mali pumilae, Fructus Citri junoris and Corm Eleocharitis being removed the peel together stripping and slicing is placed in clean container, add step (1)-(2) gained smalls, Rhizoma Dioscoreae powder and breaking cellular wall Pollen Pini, mix thoroughly, with the stewing 20-40 minute of preservative film parcel, be placed on food steamer and steam 28-46 minute, taking-up is dried in the air cool;
(5) step (4) gains and step (3) gained mixed liquor are mixed thoroughly, decoct and stir 18-26 minute, filter, elimination residue, add white sugar and dextrin mixing in filtrate, high temperature sterilize, subpackage and get final product.
The preparation method of above-mentioned drop, step (1) adds light salt brine immersion 2.5-3.5 hour (preferred, the light salt brine adding 90 DEG C soaks 3 hours) of 85-95 DEG C.
The preparation method of above-mentioned drop, step (2) by a flag with soaking in rice vinegar 13-18 minute (preferred, by flag soaking in rice vinegar 15 minutes).
The preparation method of above-mentioned drop, step (2) stir-fries 3-5 minute repeatedly, grinds to form smalls and crosses 90-110 mesh sieve stand-by (preferred, repeatedly stir-fry 4 minutes, grinding to form smalls, to cross 100 mesh sieves stand-by).
The preparation method of above-mentioned drop, Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and Flos Lonicerae crude drug 2.5-3.5 yellow wine is doubly mixed thoroughly (preferred, to be mixed thoroughly by Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and the Flos Lonicerae yellow wine with crude drug 3 times) by step (3).
The preparation method of above-mentioned drop, each amount of water of step (3) is 2.5-3.5 times of crude drug, each decoction 55-65 minute (preferred, each amount of water is 3 times of crude drug, each decoction 60 minutes).
The preparation method of above-mentioned drop, step (4) the stewing 25-35 minute of preservative film parcel, is placed on food steamer and steams 35-38 minute (preferred, to boil in a covered pot over a slow fire 30 minutes, be placed on food steamer and steam 37 minutes with preservative film parcel).
Best using method: be the therapeutic effect making the present invention reach best, the drop made, each 1-3 drips, a twice-daily.
The pharmacological effect of each crude drug is respectively:
A flag: base is former: for Polypodiaceae subfam. Microsoroideae platymiscium of fainting climbs the herb that star faints.The property of medicine: " Chinese medicinal cryptogam ": " micro-hardship, puckery, cool." function cures mainly: clearing away heat-damp and promoting diuresis.Cure mainly stranguria, jaundice.
Radix et Rhizoma Rhei Franzenbachii: be root and the cervical region of Polygonaceae Rheum plant rheum rhabarbarum.Composition: rheum rhabarbarum root and rhizome is containing general anthraquinone 1.11%, and wherein with emodin, chrysophanol is the combined anthraquinone 1.05% of aglycon, and sequestered is 0.06%, also containing wine plant glycosides, and physcione, and containing a small amount of aloe-emodin.Also containing a large amount of tannin and rheum rhabarbarum polysaccharide.The property of medicine: bitter, cold.Return stomach, large intestine channel.Function cures mainly: removing toxic substances of purging heat, removing heat from blood clots absorbing.Cure mainly jaundice due to damp-heat, dysentery, amenorrhea is suffered from abdominal pain, and spits blood, epistaxis, traumatic injury stasis of blood pain, carbuncle furunculosis, aphthous stomatitis, burn and scald.
Rhizoma Dioscoreae powder: Rhizoma Dioscoreae is also known as Rhizoma Dioscoreae, native potato, mountain Rhizoma Dioscoreae, RHIIZOMA DIOSCOREAE fr0m Henan of China, Rhizomadioscoreae, white Rhizoma Dioscoreae, and be the medical herbs that " China's book on Chinese herbal medicine " records, medicinal source is Dioscoreaceae plant Rhizoma Dioscoreae dry rhizome.Rhizoma Dioscoreae has and nourishes strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequently, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.Rhizoma Dioscoreae has induction and produces interferon, strengthens the effect of immune function of human body.Choline contained by it and lecithin contribute to improving man memory power, normal food can body-building, slow down aging, be the health-care good product that people like.Be the main and auxiliary bionic foods made with Rhizoma amorphophalli with Rhizoma Dioscoreae, having effect of nutritious, healthcare, skin maintenance, is rare health-nutrition cuisines.
Fructus Mali pumilae: reduce cholesterol: keep the stable of blood glucose, effectively can also reduce cholesterol.Cancer-resisting: the danger reducing pulmonary carcinoma, prevention lead poisoning, procyanidin can prevent colon cancer.Blood vessel cleaning agent: improve respiratory system and pulmonary function, protection pulmonary is from polluting and the impact of flue dust.Promote gastrointestinal peristalsis: assist human body to discharge refuse, reduce harmful substance to the harm of skin.Maintain acid-base balance: Fructus Mali pumilae is basic food, eat Fructus Mali pumilae can rapidly in and too much acidic materials in body (comprising the acidic metabolite that the acidic foods such as acid that motion (sports food) produces and fish, meat, egg produce in vivo), physical strength reinforcing and resistance against diseases.Fat-reducing: Fructus Mali pumilae can increase satiety, eats ante cibum and can reduce food-intake, reaches fat-reducing object.The nature and flavor of Fructus Mali pumilae are gentle, containing abundant carbohydrate, vitamin and trace element, there are saccharide, organic acid, pectin, protein, calcium, phosphorus, potassium, ferrum, vitamin A, vitamin B, vitamin C and dietary fiber, separately containing malic acid, tartaric acid, carotene.
Fructus Citri junoris: sweet in the mouth, acid, slightly cool in nature.Energy promoting the production of body fluid to quench thirst, aid digestion, stomach function regulating.Containing compositions such as citric acid, malic acid, succinic acid, saccharide, pectin, vitamin Cs.For deficiency of stomach-Yin, thirsty vexed, insobriety; Dyspepsia, disorder of stomach-QI, vomiting of feeling sick.
Corm Eleocharitis: another name Horse hoof, black taro, Di Li.Flavor efficacy: sweet, cold.Function heat clearing away, reduce phlegm, removing food stagnancy, change wart.Be applicable to that epidemic febrile disease is quenched one's thirst, jaundice, pyretic stranguria, mass in the abdomen, conjunctival congestion, laryngopharynx swelling and pain, wart etc.Prevention acute infectious disease, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, diuresis relieving constipation is eliminated the phlegm, help digestion de-swelling, conditioning hemorrhoid or dysentery is had blood in stool, woman uterine bleeding, lung-dryness syndrome due to deficiency of YIN, phlegm-heat cough, discomfort in the throat, mass in the abdomen are gathered, conjunctival congestion is hidden from view, auxiliary effect such as to bring down a fever.In addition, Corm Eleocharitis contains a kind of antiviral substance can suppress epidemic encephalitis, influenza virus, can be used for the propagation preventing epidemic encephalitis and influenza.
Breaking cellular wall Pollen Pini: trace element, flavonoid, arginine, injection Vitamin B_6, carotene and selenium etc. contained by Pollen Pini, all there is Free Radical in purged body, the activity of body antioxidant reductase (as copper-zinc superoxide dismutase etc.) can be improved, anti-lipid peroxidation reacts, eliminate senile plaque, delaying cell aging.The Pollen Pini of non-breaking cellular wall has very strong water absorption, can dampness astringing to arrest bleeding, and external can be dispeled the wind hemostasis, refreshing body antiinflammatory, non-stimulated to skin, without the side effect such as irritated; , traumatic hemorrhage, diaper dermatitis etc. dripping to eczema, impetigo, skin erosion, dense water have good therapeutical effect.Be particularly useful for infant skin protection to feel well body, control children's skin eczema, curative effect is good, instant effect.
Herba Salviae Chinensis: have another name called Herba Salviae Chinensis, little Radix Salviae Miltiorrhizae, stone great river is the herb of Lamiaceae Salvia platymiscium Salvia chinensis.The property of medicine: feeble QI, acrid in the mouth, hardship, cold nature.Composition: herb is containing different salvianolic acid, Radix Arnebiae (Radix Lithospermi) phenolic acid, rosmarinic acid, and bisflavone, root is containing stachyose etc.Find according to modern pharmacological research, this medical instrument has effect of blood stasis-eliminating and stagnation-dissipating, clearing away heat-damp and promoting diuresis, for phlegm dyspnea, and carbuncle, jaundice due to damp-heat, the diseases such as hepatitis.
Radix Glycyrrhizae: rhizome is cylindrical, there is bud trace on surface, has marrow in the middle part of section.Feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.
Rhizoma Imperatae: sweet, cold.Gui Jing: return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Cure mainly: spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, cough due to lung-heat, gastropyretic vomiting, jaundice due to damp-heat, edema oliguria, the puckery pain of pyretic stranguria.
Sal Nitri: the crystalline solid become through processing and refining for Nitrates Sal Nitri race mineral K Sal Nitri or artifact.Composition: mainly containing potassium nitrate.Because of the difference of the place of production and refinement method, purity differs, normal amount than the impurity do not waited, as sodium chloride, potassium chloride, water etc.The property of medicine: bitter, micro-salty, temperature.Mild toxicity.GUIXIN, spleen, lung meridian.Function cures mainly: assault fortified position and attack and destroy, under diuretic rushes down, and removing toxic substances and promoting subsidence of swelling.Cure mainly heatstroke wound cold, acute filthy disease is vomited and diarrhoea, trusted subordinate's pain, jaundice ， mass in the abdomen, the puckery pain of all pouring, sore throat conjunctival congestion, carbuncle furunculosis.
Flos Lonicerae: modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, stronger restraint is had to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant disease.
Drop of the present invention " more holistic ", both neonatal jaundice can be prevented, appetite can be improved again, most importantly Chinese crude drug and fruit are combined, this is the large feature being different from Drug therapy, and this drop is prepared from according to Chinese medicine principle completely, more safe and reliable, without any side effects, to matrix without any stimulation.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 prevents the drop of neonatal jaundice, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): 5 parts, flag, Radix et Rhizoma Rhei Franzenbachii 10 parts, Rhizoma Dioscoreae powder 3 parts, Fructus Mali pumilae 3 parts, Fructus Citri junoris 1 part, Corm Eleocharitis 3 parts, breaking cellular wall Pollen Pini 1 part, Herba Salviae Chinensis 5 parts, 4 parts, Radix Glycyrrhizae, Rhizoma Imperatae 2 parts, Sal Nitri 1 part, Flos Lonicerae 3 parts.
The preparation method of above-mentioned drop, preparation process is as follows:
(1) be placed in transparent container by Sal Nitri, the light salt brine adding 80 DEG C soaks 2 hours, and forging is crisp, and it is stand-by to grind to form smalls;
(2) by flag soaking in rice vinegar 10 minutes, dryouied by pot, get appropriate food oil and pour in pot, put into a soaked flag, repeatedly stir-fry 2 minutes when surrounding plays cigarette, grinding to form smalls, to cross 80 mesh sieves stand-by;
(3) Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and the Flos Lonicerae yellow wine with crude drug 2 times is mixed thoroughly, soak 25 minutes, take out soaked crude drug, be placed in marmite, decoct with water 2 times, each amount of water is 2 times of crude drug, each decoction 50 minutes, filter, twice filtrate merges to obtain mixed liquor;
(4) Fructus Mali pumilae, Fructus Citri junoris and Corm Eleocharitis are removed the peel together stripping and slicing to be placed in clean container, add step (1)-(2) gained smalls, Rhizoma Dioscoreae powder and breaking cellular wall Pollen Pini, mix thoroughly, boil in a covered pot over a slow fire 20 minutes with preservative film parcel, be placed on food steamer and steam 28 minutes, taking-up is dried in the air cool;
(5) step (4) gains and step (3) gained mixed liquor are mixed thoroughly, decoct and stir 18 minutes, filter, elimination residue, add white sugar and dextrin mixing in filtrate, high temperature sterilize, subpackage and get final product.
Model case one: king XX, man, is people from Jinan, is born 19 days, first visit on June 26 in 1999.Main suit: xanthochromia more than 2 weeks, infant cesarean, find that skin is yellow the 3rd day puerperal, within 2 weeks, looking into liver function serum bilirubin 150umol/L, glutamate pyruvate transaminase 40u/L, within several days, examining because seeing that jaundice loses to alleviate, current infant yellow sclera, face and body skin jaundice, yellow urine, nearly doctor advised uses gained of the present invention to prevent the drop of neonatal jaundice.
Use the present embodiment 1 gained drop, medication is after 1 day, and jaundice obviously alleviates, continuous with jaundice disappearance in 2 days, follows up a case by regular visits to and does not recur.
Embodiment 2: the drop of prevention neonatal jaundice, takes off the primary raw material stating weight proportion and is prepared from (getting 5g for every part): 15 parts, flag, Radix et Rhizoma Rhei Franzenbachii 20 parts, Rhizoma Dioscoreae powder 9 parts, Fructus Mali pumilae 7 parts, Fructus Citri junoris 5 parts, Corm Eleocharitis 8 parts, breaking cellular wall Pollen Pini 5 parts, Herba Salviae Chinensis 15 parts, 10 parts, Radix Glycyrrhizae, Rhizoma Imperatae 6 parts, Sal Nitri 5 parts, Flos Lonicerae 8 parts.
The preparation method of above-mentioned drop, preparation process is as follows:
(1) be placed in transparent container by Sal Nitri, the light salt brine adding 100 DEG C soaks 4 hours, and forging is crisp, and it is stand-by to grind to form smalls;
(2) by flag soaking in rice vinegar 20 minutes, dryouied by pot, get appropriate food oil and pour in pot, put into a soaked flag, repeatedly stir-fry 6 minutes when surrounding plays cigarette, grinding to form smalls, to cross 120 mesh sieves stand-by;
(3) Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and the Flos Lonicerae yellow wine with crude drug 4 times is mixed thoroughly, soak 45 minutes, take out soaked crude drug, be placed in marmite, decoct with water 2 times, each amount of water is 4 times of crude drug, each decoction 70 minutes, filter, twice filtrate merges to obtain mixed liquor;
(4) Fructus Mali pumilae, Fructus Citri junoris and Corm Eleocharitis are removed the peel together stripping and slicing to be placed in clean container, add step (1)-(2) gained smalls, Rhizoma Dioscoreae powder and breaking cellular wall Pollen Pini, mix thoroughly, boil in a covered pot over a slow fire 40 minutes with preservative film parcel, be placed on food steamer and steam 46 minutes, taking-up is dried in the air cool;
(5) step (4) gains and step (3) gained mixed liquor are mixed thoroughly, decoct and stir 26 minutes, filter, elimination residue, add white sugar and dextrin mixing in filtrate, high temperature sterilize, subpackage and get final product.
Embodiment 3: the drop of prevention neonatal jaundice, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part): 8 parts, flag, Radix et Rhizoma Rhei Franzenbachii 13 parts, Rhizoma Dioscoreae powder 5 parts, Fructus Mali pumilae 4 parts, Fructus Citri junoris 2 parts, Corm Eleocharitis 4 parts, breaking cellular wall Pollen Pini 2 parts, Herba Salviae Chinensis 8 parts, 6 parts, Radix Glycyrrhizae, Rhizoma Imperatae 3 parts, Sal Nitri 2 parts, Flos Lonicerae 4 parts.
State the preparation method of drop, preparation process is as follows:
(1) be placed in transparent container by Sal Nitri, the light salt brine adding 85 DEG C soaks 2.5 hours, and forging is crisp, and it is stand-by to grind to form smalls;
(2) by flag soaking in rice vinegar 13 minutes, dryouied by pot, get appropriate food oil and pour in pot, put into a soaked flag, repeatedly stir-fry 3 minutes when surrounding plays cigarette, grinding to form smalls, to cross 90 mesh sieves stand-by;
(3) Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and the Flos Lonicerae yellow wine with crude drug 2.5 times is mixed thoroughly, soak 30 minutes, take out soaked crude drug, be placed in marmite, decoct with water 2 times, each amount of water is 2.5 times of crude drug, each decoction 55 minutes, filter, twice filtrate merges to obtain mixed liquor;
(4) Fructus Mali pumilae, Fructus Citri junoris and Corm Eleocharitis are removed the peel together stripping and slicing to be placed in clean container, add step (1)-(2) gained smalls, Rhizoma Dioscoreae powder and breaking cellular wall Pollen Pini, mix thoroughly, boil in a covered pot over a slow fire 25 minutes with preservative film parcel, be placed on food steamer and steam 35 minutes, taking-up is dried in the air cool;
(5) step (4) gains and step (3) gained mixed liquor are mixed thoroughly, decoct and stir 20 minutes, filter, elimination residue, add white sugar and dextrin mixing in filtrate, high temperature sterilize, subpackage and get final product.
Embodiment 4: the drop of prevention neonatal jaundice, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part): 13 parts, flag, Radix et Rhizoma Rhei Franzenbachii 18 parts, Rhizoma Dioscoreae powder 7 parts, Fructus Mali pumilae 6 parts, Fructus Citri junoris 4 parts, Corm Eleocharitis 7 parts, breaking cellular wall Pollen Pini 4 parts, Herba Salviae Chinensis 13 parts, 8 parts, Radix Glycyrrhizae, Rhizoma Imperatae 5 parts, Sal Nitri 4 parts, Flos Lonicerae 7 parts.
The preparation method of above-mentioned drop, preparation process is as follows:
(1) be placed in transparent container by Sal Nitri, the light salt brine adding 95 DEG C soaks 3.5 hours, and forging is crisp, and it is stand-by to grind to form smalls;
(2) by flag soaking in rice vinegar 18 minutes, dryouied by pot, get appropriate food oil and pour in pot, put into a soaked flag, repeatedly stir-fry 5 minutes when surrounding plays cigarette, grinding to form smalls, to cross 110 mesh sieves stand-by;
(3) Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and the Flos Lonicerae yellow wine with crude drug 3.5 times is mixed thoroughly, soak 40 minutes, take out soaked crude drug, be placed in marmite, decoct with water 2 times, each amount of water is 3.5 times of crude drug, each decoction 65 minutes, filter, twice filtrate merges to obtain mixed liquor;
(4) Fructus Mali pumilae, Fructus Citri junoris and Corm Eleocharitis are removed the peel together stripping and slicing to be placed in clean container, add step (1)-(2) gained smalls, Rhizoma Dioscoreae powder and breaking cellular wall Pollen Pini, mix thoroughly, boil in a covered pot over a slow fire 35 minutes with preservative film parcel, be placed on food steamer and steam 38 minutes, taking-up is dried in the air cool;
(5) step (4) gains and step (3) gained mixed liquor are mixed thoroughly, decoct and stir 24 minutes, filter, elimination residue, add white sugar and dextrin mixing in filtrate, high temperature sterilize, subpackage and get final product.
Model case two: yellow XX, female, Jinan, Shandong Province personage, main suit: more than the skin yellow moon, infant is born yellowing of the skin in a couple of days, nearly more than ten sky skin Huangs increase the weight of, vomiting, abdominal distention, JIUYUE Fengtai County on the 29th the People's Hospital looks into abnormal liver function, healthcare hospital for women & children of JIUYUE 30 Zhu Ru Huainan City, because looking into HBsAb+ after being admitted to hospital, HBcAb+, suggestion turns the contagious department treatment of First People's Hospital of Huainan City, but suffer from house and automatically turn to our hospital, examine as neonatal jaundice (INFANT HEPATITIS SYNDROME), so doctor advised uses gained of the present invention to prevent the drop of neonatal jaundice.
Use the present embodiment 4 gained drop, after 2 days, after infant clothes, jaundice alleviates gradually, continues and transfers to normally by 5 days jaundice, follows up a case by regular visits to without recurrence.
Embodiment 5: the drop of prevention neonatal jaundice, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): 10 parts, flag, Radix et Rhizoma Rhei Franzenbachii 15 parts, Rhizoma Dioscoreae powder 6 parts, Fructus Mali pumilae 5 parts, Fructus Citri junoris 3 parts, Corm Eleocharitis 5.5 parts, breaking cellular wall Pollen Pini 3 parts, Herba Salviae Chinensis 10 parts, 7 parts, Radix Glycyrrhizae, Rhizoma Imperatae 4 parts, Sal Nitri 3 parts, Flos Lonicerae 5 parts.
The preparation method of above-mentioned drop, preparation process is as follows:
(1) be placed in transparent container by Sal Nitri, the light salt brine adding 90 DEG C soaks 3 hours, and forging is crisp, and it is stand-by to grind to form smalls;
(2) by flag soaking in rice vinegar 15 minutes, dryouied by pot, get appropriate food oil and pour in pot, put into a soaked flag, repeatedly stir-fry 4 minutes when surrounding plays cigarette, grinding to form smalls, to cross 100 mesh sieves stand-by;
(3) Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and the Flos Lonicerae yellow wine with crude drug 3 times is mixed thoroughly, soak 35 minutes, take out soaked crude drug, be placed in marmite, decoct with water 2 times, each amount of water is 3 times of crude drug, each decoction 60 minutes, filter, twice filtrate merges to obtain mixed liquor;
(4) Fructus Mali pumilae, Fructus Citri junoris and Corm Eleocharitis are removed the peel together stripping and slicing to be placed in clean container, add step (1)-(2) gained smalls, Rhizoma Dioscoreae powder and breaking cellular wall Pollen Pini, mix thoroughly, boil in a covered pot over a slow fire 30 minutes with preservative film parcel, be placed on food steamer and steam 37 minutes, taking-up is dried in the air cool;
(5) step (4) gains and step (3) gained mixed liquor are mixed thoroughly, decoct and stir 22 minutes, filter, elimination residue, add white sugar and dextrin mixing in filtrate, high temperature sterilize, subpackage and get final product.
The clinical practice of the drop of test example 1 embodiment 5 gained prevention neonatal jaundice: screen 100 routine patients in 4 hospitals, before test 2 days, Continuous Observation is carried out to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group uses embodiment 5 products obtained therefrom, and matched group uses other medicine.
Curative effect situation criterion: effectively: after taking this product, malaise symptoms disappears; Invalid: after taking this product, health is unchanged.Result is as shown in table 1.
Table 1: use embodiment 5 gained drop compliance test result
Experimental group Matched group
Number of cases 50 50
Effective number of cases 49 35
Invalid number of cases 1 15
Obvious effective rate 98% 70%
Therapeutic effect: effective 49 examples (98%), invalid 1 example (2%), obvious effective rate 96%, successful is better than matched group.And invalid in 2 people use after a period of time in continuation, malaise symptoms disappears, and therefore do not get rid of and make result deviation to some extent because service time is short, between the operating period, malaise symptoms or side effect appear in no one.

Claims (10)

1. prevent a drop for neonatal jaundice, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: a flag 5-15 part, Radix et Rhizoma Rhei Franzenbachii 10-20 part, Rhizoma Dioscoreae powder 3-9 part, Fructus Mali pumilae 3-7 part, Fructus Citri junoris 1-5 part, Corm Eleocharitis 3-8 part, breaking cellular wall Pollen Pini 1-5 part, Herba Salviae Chinensis 5-15 part, Radix Glycyrrhizae 4-10 part, Rhizoma Imperatae 2-6 part, Sal Nitri 1-5 part, Flos Lonicerae 3-8 part.
2. the drop of prevention neonatal jaundice according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: a flag 8-13 part, Radix et Rhizoma Rhei Franzenbachii 13-18 part, Rhizoma Dioscoreae powder 5-7 part, Fructus Mali pumilae 4-6 part, Fructus Citri junoris 2-4 part, Corm Eleocharitis 4-7 part, breaking cellular wall Pollen Pini 2-4 part, Herba Salviae Chinensis 8-13 part, Radix Glycyrrhizae 6-8 part, Rhizoma Imperatae 3-5 part, Sal Nitri 2-4 part, Flos Lonicerae 4-7 part.
3. the drop of prevention neonatal jaundice according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: 10 parts, flag, Radix et Rhizoma Rhei Franzenbachii 15 parts, Rhizoma Dioscoreae powder 6 parts, Fructus Mali pumilae 5 parts, Fructus Citri junoris 3 parts, Corm Eleocharitis 5.5 parts, breaking cellular wall Pollen Pini 3 parts, Herba Salviae Chinensis 10 parts, 7 parts, Radix Glycyrrhizae, Rhizoma Imperatae 4 parts, Sal Nitri 3 parts, Flos Lonicerae 5 parts.
4. according to any one of claim 1-3, prevent the preparation method of the drop of neonatal jaundice, it is characterized in that: step is as follows:
(1) be placed in transparent container by Sal Nitri, the light salt brine adding 80-100 DEG C soaks 2-4 hour, and forging is crisp, and it is stand-by to grind to form smalls;
(2) by a flag soaking in rice vinegar 10-20 minute, dryouied by pot, get appropriate food oil and pour in pot, when surrounding plays cigarette, put into a soaked flag, stir-fry 2-6 minute repeatedly, and grinding to form smalls, to cross 80-120 mesh sieve stand-by;
(3) Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and Flos Lonicerae crude drug 2-4 yellow wine is doubly mixed thoroughly, soak 25-45 minute, take out soaked crude drug, be placed in marmite, decoct with water 2 times, each amount of water is 2-4 times of crude drug, each decoction 50-70 minute, filter, twice filtrate merges to obtain mixed liquor;
(4) Fructus Mali pumilae, Fructus Citri junoris and Corm Eleocharitis being removed the peel together stripping and slicing is placed in clean container, add step (1)-(2) gained smalls, Rhizoma Dioscoreae powder and breaking cellular wall Pollen Pini, mix thoroughly, with the stewing 20-40 minute of preservative film parcel, be placed on food steamer and steam 28-46 minute, taking-up is dried in the air cool;
(5) step (4) gains and step (3) gained mixed liquor are mixed thoroughly, decoct and stir 18-26 minute, filter, elimination residue, add white sugar and dextrin mixing in filtrate, high temperature sterilize, subpackage and get final product.
5. the preparation method of drop according to claim 4, is characterized in that: the light salt brine that step (1) adds 85-95 DEG C soaks 2.5-3.5 hour (preferred, the light salt brine adding 90 DEG C soaks 3 hours).
6. the preparation method of drop according to claim 4, is characterized in that: step (2) is by flag soaking in rice vinegar 13-18 minute (preferred, by flag soaking in rice vinegar 15 minutes).
7. the preparation method of drop according to claim 4, is characterized in that: step (2) stir-fries 3-5 minute repeatedly, grinds to form smalls and crosses 90-110 mesh sieve stand-by (preferred, repeatedly stir-fry 4 minutes, grinding to form smalls, to cross 100 mesh sieves stand-by).
8. the preparation method of drop according to claim 4, it is characterized in that: Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and Flos Lonicerae crude drug 2.5-3.5 yellow wine is doubly mixed thoroughly (preferred, to be mixed thoroughly by Radix et Rhizoma Rhei Franzenbachii, Herba Salviae Chinensis, Radix Glycyrrhizae, Rhizoma Imperatae and the Flos Lonicerae yellow wine with crude drug 3 times) by step (3).
9. the preparation method of drop according to claim 4, is characterized in that: each amount of water of step (3) be the 2.5-3.5 of crude drug doubly, to decoct 55-65 minute (preferred, each amount of water is 3 times of crude drug, each decoct 60 minutes) at every turn.
10. the preparation method of drop according to claim 4, is characterized in that: the stewing 25-35 minute of step (4) preservative film parcel, is placed on food steamer and steams 35-38 minute (preferred, with stewing 30 minutes of preservative film parcel, to be placed on food steamer and to steam 37 minutes).
CN201610023123.6A 2016-01-14 2016-01-14 Drop for preventing neonatal jaundice and preparation method of drop Pending CN105521338A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112870234A (en) * 2021-01-27 2021-06-01 四川九章生物科技有限公司 Application of pharmaceutical composition containing chlorogenic acid in preparation of medicines for treating pathological jaundice

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102935182A (en) * 2012-10-13 2013-02-20 凤台县经济开发区中医药研究所 Neonatal jaundice treatment decoction
CN103536790A (en) * 2013-10-14 2014-01-29 刘文武 Traditional Chinese medicine for treating acute icteric hepatitis
CN104984303A (en) * 2015-07-31 2015-10-21 山东省立医院 Traditional Chinese medicine composite for treating child jaundice

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102935182A (en) * 2012-10-13 2013-02-20 凤台县经济开发区中医药研究所 Neonatal jaundice treatment decoction
CN103536790A (en) * 2013-10-14 2014-01-29 刘文武 Traditional Chinese medicine for treating acute icteric hepatitis
CN104984303A (en) * 2015-07-31 2015-10-21 山东省立医院 Traditional Chinese medicine composite for treating child jaundice

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112870234A (en) * 2021-01-27 2021-06-01 四川九章生物科技有限公司 Application of pharmaceutical composition containing chlorogenic acid in preparation of medicines for treating pathological jaundice

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Application publication date: 20160427