CN105497856A - 用于化疗引起的末梢神经损伤导致的肢端***中药 - Google Patents

用于化疗引起的末梢神经损伤导致的肢端***中药 Download PDF

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CN105497856A
CN105497856A CN201610014781.9A CN201610014781A CN105497856A CN 105497856 A CN105497856 A CN 105497856A CN 201610014781 A CN201610014781 A CN 201610014781A CN 105497856 A CN105497856 A CN 105497856A
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张清
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Shandong Provincial Hospital
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Abstract

本发明公开了一种用于化疗引起的末梢神经损伤导致的肢端***中药，包括以下原料：白芍，桂枝，生姜，熟地，川芎，当归，黄芪，大枣，桃仁、全蝎、僵蚕、党参、茯苓、马钱子、木防己、铁扫竹、五加皮、鸡血藤、秦艽、土元、蚕砂。本发明以多味中药为原料，科学配伍，各原料药之间协同作用，具有通络开痹，养血补气的功效，疗程短，见效快，治疗率高，安全无毒副作用，值得推广。

Description

用于化疗引起的末梢神经损伤导致的肢端***中药
技术领域
本发明涉及中药技术领域，具体涉及一种用于化疗引起的末梢神经损伤导致的肢端***中药。
背景技术
化疗是对病原微生物、寄生虫、恶性肿瘤所致得以疾病的药物晋升治疗，这些特殊的药物可杀灭肿瘤细胞，有时称为细胞毒药物。化疗是肿瘤合作治疗的一个有效手段，但几乎所有的化疗药物都会对周围末梢神经产生损害作用，患者可出现肢端麻痹，肢端感觉迟钝等症状，如长春新碱、长春花碱、长春酰胺、诺威本等均可出现不同程度的神经毒副反应。目前针对化疗引起的末梢神经损伤导致的肢端麻痹尚没有很好的治疗方法。
发明内容
为弥补现有技术的不足，本发明提供一种疗效显著的用于化疗引起的末梢神经损伤导致的肢端***中药。
本发明是通过如下技术方案实现的：
一种用于化疗引起的末梢神经损伤导致的肢端***中药，其特殊之处在于：包括以下重量份数的原料：白芍8-15，桂枝10-15，生姜5-9，熟地5-8，川芎8-15，当归8-15，黄芪10-15，大枣12-15，桃仁8-15、全蝎3-8、僵蚕4-9、党参10-15、茯苓3-7、马钱子2-6、木防己8-10、铁扫竹5-10、五加皮6-9、鸡血藤8-12、秦艽8-12、土元3-5、蚕砂10-15。
本发明的用于化疗引起的末梢神经损伤导致的肢端***中药，在上述原料基础上继续添加以下重量份数的原料：射罔4-8、雪莲花6-12、覆盆子3-5、蚌兰叶4-7、红花3-6。
本发明的用于化疗引起的末梢神经损伤导致的肢端***中药，优选以下重量份数的原料：白芍10，桂枝15，生姜6，熟地6，川芎10，当归10，黄芪12，大枣，桃仁10、全蝎5、僵蚕5、党参12、茯苓6、马钱子4、木防己9、铁扫竹9、五加皮8、鸡血藤10、秦艽10、土元4、蚕砂12。
本发明中各原料药的作用如下：
白芍：味苦、酸，性微寒。归肝、脾经。养血调经，敛阴止汗，柔肝止痛，平抑肝阳。用于血虚萎黄，***，自汗，盗汗，胁痛，腹痛，四肢挛痛，头痛眩晕。
桂枝：味辛、甘，性温。归肺、心、膀胱经。发汗解表、散寒止痛、通阳化气。用于风寒感冒、寒凝血滞诸痛症、痰饮、蓄水证、心悸。
生姜：味辛，性微温。归肺、脾、胃经。解表散寒，温中止呕，温肺止咳，解毒。风寒感冒，脾胃寒症，胃寒呕吐，肺寒咳嗽，解鱼蟹毒。
熟地：味甘，微温。归肝、肾经。补血养阴，填精益髓。可用于血虚萎黄，眩晕，心悸失眠，***，崩漏等症，亦可用于肾阴不足的潮热骨蒸、盗汗、遗精、消渴等症。
川芎：味辛，温。入肝、胆经。行气开郁，法风燥湿，活血止痛。治风冷头痛旋晕，胁痛腹疼，寒痹筋挛，经闭，难产，产后瘀阻块痛，痈疽疮疡。用于***，经闭痛经，瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。
当归：味甘、辛，性温。归肝、心、脾经。补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，***，经闭痛经，虚寒腹痛，风湿痹痛，跌扑损伤，痈疽疮疡，肠燥便秘。酒当归活血通经。用于经闭痛经，风湿痹痛，跌扑损伤。
黄芪：味甘，微温。归肺、脾、肝、肾经。益气固表、敛汗固脱、托疮生肌、利水消肿。用于治疗气虚乏力，中气下陷，久泻脱肛，便血崩漏，表虚自汗，痈疽难溃，久溃不敛，血虚萎黄，内热消渴，慢性肾炎，蛋白尿，糖尿病等。炙黄芪益气补中，生用固表托疮。
大枣：味甘性温。归脾胃经。补中益气、养血安神、缓和药性。用于脾胃气虚、血虚萎黄、血虚失眠多梦等症的治疗。
桃仁：味苦、甘，平。归心、肝、大肠经。活血祛瘀，润肠通便，止咳平喘。用于经闭痛经，瘕瘕痞块，肺痈肠痈，跌扑损伤，肠燥便秘，咳嗽气喘。
全蝎：味辛，平。归肝经。息风镇痉，通络止痛，攻毒散结。用于肝风内动，痉挛抽搐，小儿惊风，中风口，半身不遂，破伤风，风湿顽痹，偏正头痛，疮疡，瘰疬。
僵蚕：味咸、辛，性平。归肝、肺、胃经。息风止痉，祛风止痛，化痰散结。用于肝风夹痰，惊痫抽搐，小儿急惊，破伤风，中风口，风热头痛，目赤咽痛，风疹瘙痒，发颐痄腮。
党参：味甘，平。归脾、肺经。补中，益气，生津。主治脾胃虚弱，气血两亏，体倦无力，食少，口渴，久泻，脱肛。
茯苓：味甘、淡，性平。归心、肺、脾、肾经。利水渗湿，健脾，宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
马钱子：味苦、温。归肝、脾经。有通络止痛，散结消肿的作用。用于跌打损伤，骨折肿痛，风湿顽痹，麻木瘫痪，痈疽疮毒，咽喉肿痛。
木防己：味辛、苦，性寒。归膀胱、肺经。祛风止痛，行水清肿，解毒，降血压。用于风湿痹痛、神经痛、肾炎水肿、***；外治跌打损伤、蛇咬伤。
铁扫竹：性凉，味苦涩，无毒。治创伤，肿毒，口疮，臁疮，吐血，水泻。
五加皮：味辛、苦，性温。肝、肾经。有祛风湿，补益肝肾，强筋壮骨，利水消肿的作用。用于风湿痹病，筋骨痿软，小儿行迟，体虚乏力，水肿，脚气。
鸡血藤：味苦、甘，温。归肝、肾经。活血补血，调经止痛，舒筋活络。用于***，痛经，经闭，风湿痹痛，麻木瘫痪，血虚萎黄。
秦艽：味辛、苦，性平。归胃、肝、胆经。有祛风湿，清湿热，止痹痛，退虚热的作用。用于风湿痹痛，中风半身不遂，筋脉拘挛，骨节酸痛，湿热黄疸，骨蒸潮热，小儿疳积发热。
土元：味咸，寒；有小毒。归肝经。破瘀血，续筋骨。用于血瘀经闭、跌打损伤及症瘕肿块。
蚕砂：性味甘温。入肝、脾、胃经。燥湿祛风，和胃化浊，活血定痛。用于风湿痹痛、头风、头痛、皮肤瘙痒、腰腿冷痛、腹痛吐泻等症。
射罔：味苦，热，有毒。治瘰疬结核，瘘疮毒肿，头风，风痹，腹中症结，疟疾，疝气。
雪莲花：性微凉、味甘。入肺肾经。美容养颜、疏通理气。具有通经活血、散寒除湿、止血消肿、排体内毒素等功效。
覆盆子：味甘、酸，性温。归肝、肾、膀胱经。益肾固精缩尿，养肝明目。用于遗精滑精，遗尿尿频，阳痿早泄，目暗昏花。
蚌兰叶：味甘，凉清热，止血，去瘀。治肺热燥咳，吐血，便血，尿血，痢疾，跌打损伤。
红花：味辛，性温。归心、肝经。活血通经，散瘀止痛。用于经闭，痛经，恶露不行，症瘕痞块，胸痹心痛，瘀滞腹痛，胸胁刺痛，跌扑损伤，疮疡肿痛。
本发明的有益效果是：本发明以多味中药为原料，科学配伍，各原料药之间协同作用，具有通络开痹，养血补气的功效，疗程短，见效快，治疗率高，安全无毒副作用。
具体实施方式
实施例1
中药组份：白芍8克，桂枝10克，生姜5克，熟地5克，川芎8克，当归8克，黄芪10克，大枣12克，桃仁8克、全蝎3克、僵蚕4克、党参10克、茯苓3克、马钱子2克、木防己8克、铁扫竹5克、五加皮6克、鸡血藤8克、秦艽8克、土元3克、蚕砂10克、射罔4克、雪莲花6克、覆盆子3克、蚌兰叶4克、红花3克。
制备工艺：将处方量药材加水煎煮3次，合并煎液。每日一剂，早、晚各服一次，5天一个疗程。
实施例2
中药组份：白芍10克，桂枝15克，生姜6克，熟地6克，川芎10克，当归10克，黄芪12克，大枣克，桃仁10克、全蝎5克、僵蚕5克、党参12克、茯苓6克、马钱子4克、木防己9克、铁扫竹9克、五加皮8克、鸡血藤10克、秦艽10克、土元4克、蚕砂12克。
制备工艺：将处方量药材加水煎煮3次，合并煎液。每日一剂，早、晚各服一次，5天一个疗程。
实施例3
中药组份：白芍15克，桂枝15克，生姜9克，熟地8克，川芎15克，当归15克，黄芪15克，大枣15克，桃仁15克、全蝎8克、僵蚕9克、党参15克、茯苓7克、马钱子6克、木防己10克、铁扫竹10克、五加皮9克、鸡血藤12克、秦艽12克、土元5克、蚕砂15克、射罔8克、雪莲花12克、覆盆子5克、蚌兰叶7克、红花6克。
制备工艺：将处方量药材加水煎煮3次，合并煎液。每日一剂，早、晚各服一次，5天一个疗程。
实施例4：临床观察
（1）一般资料
本发明人于2013年至今对200例患者进行临床观察治疗，治愈180人，有效14人，总有效率高达97%。
（2）治疗方法：每日一剂，早、晚各服一次，5天一个疗程。
（3）疗效评定标准
治愈：症状体征完全消失；
有效：症状体征较减轻；
无效：症状体征与治疗前无改善。
（4）典型病例：
姜某某，43岁，化疗后出现手掌足跟麻木、瘙痒、无痛性红斑和肿胀现象，于2013年8月开始服用本发明的中药，每日一剂，早、晚各服一次，5天一疗程，三个疗程后痊愈。
赵某，69岁，化疗后出现指端麻木、腱反射减弱或消失、感觉异常、少数可发生感觉消失，垂足，肌肉萎缩或麻木、直立性低血压，膀胱张力减弱、便秘现象，于2014年5月开始服用本发明的中药，每日一剂，早、晚各服一次，5天一疗程，五个疗程后痊愈。
张某某，51岁，化疗后出现手足麻木，犹如虫行，面色苍白，自汗，气短乏力，嗜卧懒言，易感冒，大便稀溏，舌淡，舌体胖大，苔薄白，脉弱现象，于2015年1月开始服用本发明的中药，每日一剂，早、晚各服一次，5天一疗程，五个疗程后痊愈。

Claims (3)

1.一种用于化疗引起的末梢神经损伤导致的肢端***中药，其特征在于：包括以下重量份数的原料：白芍8-15，桂枝10-15，生姜5-9，熟地5-8，川芎8-15，当归8-15，黄芪10-15，大枣12-15，桃仁8-15、全蝎3-8、僵蚕4-9、党参10-15、茯苓3-7、马钱子2-6、木防己8-10、铁扫竹5-10、五加皮6-9、鸡血藤8-12、秦艽8-12、土元3-5、蚕砂10-15。
2.根据权利要求1所述的用于化疗引起的末梢神经损伤导致的肢端***中药，其特征在于：还包括以下重量份数的原料：射罔4-8、雪莲花6-12、覆盆子3-5、蚌兰叶4-7、红花3-6。
3.根据权利要求1所述的用于化疗引起的末梢神经损伤导致的肢端***中药，其特征在于：包括以下重量份数的原料：白芍10，桂枝15，生姜6，熟地6，川芎10，当归10，黄芪12，大枣，桃仁10、全蝎5、僵蚕5、党参12、茯苓6、马钱子4、木防己9、铁扫竹9、五加皮8、鸡血藤10、秦艽10、土元4、蚕砂12。
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