CN105497157A - Medicine used for treating alopecia cicatrisata - Google Patents
Medicine used for treating alopecia cicatrisata Download PDFInfo
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Abstract
The invention relates to medicine used for treating alopecia cicatrisata. The medicine is prepared from, by weight, 20 parts of stellaria dichotoma, 15 parts of caulis spatholobi, 15 parts of tuber fleeceflower stems, 6 parts of liquorice roots, 9 parts of tribulus terrestris, 8 parts of radix lithospermi, 12 parts of fir fruit, 15 parts of serissa japonica, 12 parts of agrimonia pilosa ldb and 12 parts of pittosporoides sleum. According to application of the medicine, stellaria dichotoma tonifies the liver, quiets the heart, arrests sweating and promotes the secretion of saliva or body fluid; caulis spatholobi enriches the blood, and promotes blood circulation to remove mederidian obstruction; tuber fleeceflower stems nourish blood for tranquilization, dispel wind and remove obstruction in the meridians; tribulus terrestris calms the liver, dispels melancholy, and dispels the wind; radix lithospermi cools the blood, activates the blood, removes toxic materials and promotes eruption; the fir fruit removes dampness and regulates qi; serissa japonica dispels the wind, relieves exterior syndromes, clears heat and promotes diuresis; agrimonia pilosa ldb clears heat, benefits dryness, tonifies deficiency and activates the blood; pittosporoides sleum dispels the wind, eliminates dampness, regulates qi and disperses cold; the liquorice roots tonify the spleen and qi, clear away heat and toxic materials, expel phlegm to arrest coughing, relive emergency, stop pain, and moderate the property of herbs. All the drugs are combined, and have the functions of soothing the liver, regulating qi, removing blood stasis, promoting fresh blood production, nourishing the blood, expelling the wind, tonifying qi and promoting hair generation. Clinical experiments prove that the medicine can treat alopecia cicatrisata safely and effectively.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine being used for the treatment of cicatricial alopecia.
Background technology
Cicatricial alopecia is the patchy alopecia trichopathy of a kind of limitation suddenly occurred, and its lesion scalp is normal, NIP and subjective symptoms.The primary disease course of disease, can spontaneous remission and recurrence through slow.If whole hair of scalp all comes off, claim alopecia totalis; The person if all hairs of whole body all do not come off, claims alopecia universalis.Cicatricial alopecia can occur in any age from baby to old man, but more with middle age, and sex difference is not obvious.Primary disease is longer than and is stumbled on or found by other people, and no conscious sympton, minority case at the initial stage of a disease affected part can have mile abnormality to feel.
Cicatricial alopecia is dermatology common disease, and be a kind of damage capacitive disease, the traditional Chinese medical science is referred to as " alopecia areata is sick ", and alopecia is many because of weakness of the spleen and stomach, deficiency of the liver and kindey, deficiency of YIN-blood, disharmony between QI and blood, qi depression to blood stasis, and wind heat blood is dry, and feelings will is hindered and causes.Hair is the sign of blood condition, and taste are the source of QI and bloodization life, therefore the prosperity and decline of its function can affect hair.In addition, the kidney generating marrow and dominating bone, " its Hua Fa ", and if deficiency of kidney-QI, deficiency of the kidney, then dried and withered hairs hair dropped.Therefore, the heart of alopecia and essence, blood and internal organs, spleen, liver, kidney have substantial connection.
Clinical manifestation: the alopecia spot of circle or ellipse appears suddenly in head, number is not etc., not of uniform size, clear border, expands gradually or alopecia district increases, local skin NIP phenomenon, and smoothly light, without any subjective symptoms, is found often.Also a few patients is had can to see erythema and edema in alopecia district in early days.Alopecia district skin is normal, and the hair at its edge often loosens, and is drawn out easily very much, visible dry near-end atrophy when extracting, and upper coarse and lower fine as exclamation mark sample.Cicatricial alopecia generally betides scalp, but also can occur in other position, as the place such as eyebrow, beard.The lighter can have a slice or number small pieces alopecia district, and the case that severe one accounts for 5% ~ 10% continues to develop into mutual fusion, and large stretch of or full capillus falling out, claims alopecia totalis in a short time.Time more serious, eyebrow, beard, armpit hair, pubes, fine hair on birds or animals hair etc. are all tear-away, are called alopecia universalis.
The diagnosis of this disease is main relies on the detection of lab testing 1. body's immunity, comprises interleukin II and acceptor levels measures, T lymphocyte and Subsets thereof, NK cellular level mensuration etc.2. hair microelement detects (CU, Pc, Ca, Zu, Mn, Pb).3. endocrine detects, the growth of hair is by the direct or indirect regulating and controlling of endocrine, as adrenocortical hormone increases, can cause hirsutism, testosterone can promote trunk, extremity, the hair growth of palpus portion and pudendum, in addition, thyroid, parathyroid gland, the function of hypophysis etc. also plays an important role in the course of disease of cicatricial alopecia.4. skin of head microcirculation detects, and microcirculatory perfusion plays an important role in the growth and regrowth process of hair.5. scalp pathological section.
Drug therapy is circulatory system drug 1., as minoxidil; 2. corticosteroid hormone, as prednisone has antiinflammatory and immunosuppressive action; 3. neuroregulation medicine, oryzanol has the effect of good trophic nerve, can improve autonomic nervous dysfunction, has certain regulating action to neurasthenia patient; Simultaneously can stabilizing the emotions, anxiety reduction and tense situation.4. thymosin: the mechanism for the treatment of cicatricial alopecia may be the immunity of the abnormal T cell mediation stimulating SC poison T cell and correct cicatricial alopecia.5. vitamin B1, B6, action and function is mainly reflected in the aspect such as blood, muscle, nerve, skin of human body, can the synthesis of enhancing antibody, in digestive system gastric acid manufacture, fat and protein utilization, maintain sodium/potassium balance (stablizing nervous system).6. treatment by Chinese herbs cicatricial alopecia can use traditional Chinese medical herbal treatment, and effectiveness comparison is desirable.Should be careful in one's diet and living habit simultaneously.
Medical material involved in the present invention is recorded in all as seen " China's book on Chinese herbal medicine ".
Summary of the invention
The present invention aims to provide a kind of medicine being used for the treatment of cicatricial alopecia, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing cicatricial alopecia.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of medicine being used for the treatment of cicatricial alopecia, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Herba Stellariae dichotomae 20 parts, Caulis Spatholobi 15 parts, Caulis Polygoni Multiflori 15 parts, 6 parts, Radix Glycyrrhizae, Fructus Atriplicis Sibiricae 9 parts, Radix Arnebiae (Radix Lithospermi) 8 parts, Semen Abietis Delavayi 12 parts, Serissa foetida 15 parts, Herba silenes fortunei 12 parts, Cortex Nothapodytis Radicis 12 parts.
Below in conjunction with theories of Chinese materia medica, beneficial effect of the present invention is described:
Inventor thinks, cicatricial alopecia many genus blood deficiency can not nourish skin, and hair loses nutrition and comes off, or nervous, and depression of liver-QI is overworked, impairment caused by overstrain heart spleen, and the biochemical weary source of QI and blood, caused by hair mistake is supported.Or deficiency of the liver and kindey, blood and essence asthenia, unable hair care and cause alopecia.Weakness of the spleen and stomach, deficiency of the liver and kindey, cloudy anemia is damaged; Or because of space between skin and muscles solid, ailment said due to cold or exposure is taken advantage of a weak point, strongly fragrant dryness-transformation of a specified duration, causes and sends out the Rong Erfa that becomes homeless; Or because of feelings will unsuccessful, the mind lose peaceful caused by.Treatment is with depressed liver-energy dispersing and QI regulating, and blood stasis dispersing and fresh blood promoting, nourishing blood to expel wind, strengthening spleen, tonifying kidney, QI invigorating hair growth promoting is main.
The present invention uses: Herba Stellariae dichotomae tonifying liver mind calming, and arresting sweating promotes the production of body fluid; Caulis Spatholobi is enriched blood, promoting blood circulation to remove obstruction in the collateral; Caulis Polygoni Multiflori nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral; Fructus Atriplicis Sibiricae suppressing the hyperactive liver resolving depression, dispels the wind; Radix Arnebiae (Radix Lithospermi) removing heat from blood and promoting blood circulation, removing toxic substances rash; Regulate the flow of vital energy during Semen Abietis Delavayi is wet; Serissa foetida dispelling wind to relieve the exterior syndrome, clearing away heat-damp and promoting diuresis; Herba silenes fortunei heat clearing away profit alunite, tonify deficiency is invigorated blood circulation; Cortex Nothapodytis Radicis expelling wind and removing dampness, cold expelling of regulating the flow of vital energy; Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicines share, altogether long memorial liver and qi, blood stasis dispersing and fresh blood promoting, nourishing blood to expel wind, the merit of QI invigorating hair growth promoting.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects 120 routine cicatricial alopecia patients between 2010 04 month-2013 years 04 month altogether.Be divided at random: treatment group 60 example, matched group 60 example.Wherein treatment group man 36 example, female 24 example, 33.78 years old mean age, the course of disease 1 week ~ 32 months; Matched group man 33 example, female 27 example, 34.22 years old mean age, the course of disease 1 week ~ 29 months.The data there was no significant differences such as two groups of sexes, age, courses of disease, have comparability.
Diagnostic criteria:
1. many spiritednesses wound of falling ill and hypertonicity history, be apt to occur in person between twenty and fifty.
2. onset is unexpected, shows as the alopecia of head generation limitation plaque-like, rounded or oval, number, differs in size, and border is obvious, level and smooth gloss after affected part alopecia, NIP and other is abnormal, and edge hair is loosening easily to be pulled out.
3. the course of disease is through slow.Some patients all can take off light by hair, claims alopecia totalis.As alopecia totalis companion eyebrow, armpit hair, pubes and the whole body fine hair on birds or animals hair person of coming off, the alopecia universalis of meaning.About can there is changes such as caving in, coarse in half patient on fingernail.
Inclusive criteria: be cicatricial alopecia through clinical definite, alopecia area is less than 30%, and at 18 ~ 65 years old age, the course of disease is not limit.
Exclusion standard: 1. alopecia totalis patient.2. other any scalp illness alopecias caused by the diseases such as tinea capitis and uloid cicatrix alopecia of patient.3. serious hepatic and kidney function obstacle person is had.4. gestation, women breast-feeding their children and patient suffer from the patient of the diseases such as coronary heart disease, hypertension, diabetes.5. merge at treatments period and use other treatment alopecia medicine person, not by specifying pill taker.
2, Therapeutic Method
The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 3, every day 3 times.Treat 3 months.
Matched group oral vitamin B1, B6,50mg/ time, 2 times/day.Treat 3 months.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
1. cure: new sending out all grows, densely distributed, hair thickness, the same normal hair of color and luster draws and sends out negative;
2. effective: new sending out grows 50% ~ 99%, has more fine hair on birds or animals hair to become coarse wool, draws and sends out negative;
3. effective: new sending out grew for 10% ~ 49% (comprising fine hair on birds or animals hair), but poor growth, draw a test positive or negative;
4. invalid: without new send out grow or kainogenesis long be less than 10% or growth limit, limit come off.
3.2 treatment statistical results are in table 1.
Table 1 liang group comparitive study
Visible, the medicine that the present invention obtains can safe and effective treatment cicatricial alopecia, and cure rate is high.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: Herba Stellariae dichotomae 20 grams, Caulis Spatholobi 15 grams, Caulis Polygoni Multiflori 15 grams, 6 grams, Radix Glycyrrhizae, Fructus Atriplicis Sibiricae 9 grams, Radix Arnebiae (Radix Lithospermi) 8 grams, Semen Abietis Delavayi 12 grams, Serissa foetida 15 grams, Herba silenes fortunei 12 grams, Cortex Nothapodytis Radicis 12 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of cicatricial alopecia.Oral, daily once.
Embodiment 2
Take: Herba Stellariae dichotomae 20 grams, Caulis Spatholobi 15 grams, Caulis Polygoni Multiflori 15 grams, 6 grams, Radix Glycyrrhizae, Fructus Atriplicis Sibiricae 9 grams, Radix Arnebiae (Radix Lithospermi) 8 grams, Semen Abietis Delavayi 12 grams, Serissa foetida 15 grams, Herba silenes fortunei 12 grams, Cortex Nothapodytis Radicis 12 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of cicatricial alopecia.Oral, every bu is taken for twice sooner or later.
Embodiment 3
Take: Herba Stellariae dichotomae 20 grams, Caulis Spatholobi 15 grams, Caulis Polygoni Multiflori 15 grams, 6 grams, Radix Glycyrrhizae, Fructus Atriplicis Sibiricae 9 grams, Radix Arnebiae (Radix Lithospermi) 8 grams, Semen Abietis Delavayi 12 grams, Serissa foetida 15 grams, Herba silenes fortunei 12 grams, Cortex Nothapodytis Radicis 12 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of cicatricial alopecia.Oral, every bu morning, noon and afternoon take for three times.
Claims (4)
1. one kind is used for the treatment of the medicine of cicatricial alopecia, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Herba Stellariae dichotomae 20 parts, Caulis Spatholobi 15 parts, Caulis Polygoni Multiflori 15 parts, 6 parts, Radix Glycyrrhizae, Fructus Atriplicis Sibiricae 9 parts, Radix Arnebiae (Radix Lithospermi) 8 parts, Semen Abietis Delavayi 12 parts, Serissa foetida 15 parts, Herba silenes fortunei 12 parts, Cortex Nothapodytis Radicis 12 parts.
2. a kind of medicine being used for the treatment of cicatricial alopecia as claimed in claim 1, it is characterized in that, its preparation method is: take: Herba Stellariae dichotomae 20 parts, Caulis Spatholobi 15 parts, Caulis Polygoni Multiflori 15 parts, 6 parts, Radix Glycyrrhizae, Fructus Atriplicis Sibiricae 9 parts, Radix Arnebiae (Radix Lithospermi) 8 parts, Semen Abietis Delavayi 12 parts, Serissa foetida 15 parts, Herba silenes fortunei 12 parts, Cortex Nothapodytis Radicis 12 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. a kind of medicine being used for the treatment of cicatricial alopecia as claimed in claim 1, it is characterized in that, its preparation method is: take: Herba Stellariae dichotomae 20 parts, Caulis Spatholobi 15 parts, Caulis Polygoni Multiflori 15 parts, 6 parts, Radix Glycyrrhizae, Fructus Atriplicis Sibiricae 9 parts, Radix Arnebiae (Radix Lithospermi) 8 parts, Semen Abietis Delavayi 12 parts, Serissa foetida 15 parts, Herba silenes fortunei 12 parts, Cortex Nothapodytis Radicis 12 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. a kind of medicine being used for the treatment of cicatricial alopecia as claimed in claim 1, it is characterized in that, its preparation method is: take: Herba Stellariae dichotomae 20 parts, Caulis Spatholobi 15 parts, Caulis Polygoni Multiflori 15 parts, 6 parts, Radix Glycyrrhizae, Fructus Atriplicis Sibiricae 9 parts, Radix Arnebiae (Radix Lithospermi) 8 parts, Semen Abietis Delavayi 12 parts, Serissa foetida 15 parts, Herba silenes fortunei 12 parts, Cortex Nothapodytis Radicis 12 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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CN106362050A (en) * | 2016-10-20 | 2017-02-01 | 赵盼 | Traditional Chinese medicine for cicatricial alopecia treatment |
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Application publication date: 20160420 |