CN105481963B - 鳐血管生成抑制因子1功能区变体jg50及其应用 - Google Patents
鳐血管生成抑制因子1功能区变体jg50及其应用 Download PDFInfo
- Publication number
- CN105481963B CN105481963B CN201610017406.XA CN201610017406A CN105481963B CN 105481963 B CN105481963 B CN 105481963B CN 201610017406 A CN201610017406 A CN 201610017406A CN 105481963 B CN105481963 B CN 105481963B
- Authority
- CN
- China
- Prior art keywords
- ray
- functional areas
- ray angiostatin
- variant
- angiostatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 鸡胚数(只) | 用药量(μg/只*天) | 血管分支点数(X拔+S) | 抑制率 |
对照组 | 5 | — | 83.5 | — |
SEQ ID NO:1蛋白 | 5 | 100 | 42.2 | 49.5% |
JG1 (9R/G) | 5 | 100 | 34.0 | 59.3% |
JG2 (9R/W) | 5 | 100 | 71.2 | 14.7% |
JG16 (17F/S) | 5 | 100 | 28.3 | 66.1% |
JG20 (42H/R) | 5 | 100 | 83.5 | 0.0% |
JG23 (42H/D) | 5 | 100 | 34.0 | 59.3% |
JG30 (57S/P) | 5 | 100 | 68.1 | 18.4% |
JG36 (57S/L) | 5 | 100 | 28.2 | 66.2% |
JG42 (62R/V) | 5 | 100 | 39.4 | 52.8% |
JG50 (71K/R) | 5 | 100 | 36.1 | 56.8% |
JG55 (80N/W) | 5 | 100 | 29.7 | 64.4% |
JG60 (89P/V) | 5 | 100 | 34.3 | 58.9% |
JG63 (100G/E) | 5 | 100 | 35.3 | 57.7% |
JG70 (101R/C) | 5 | 100 | 37.3 | 55.3% |
JG80 (129A/S) | 5 | 100 | 63.2 | 24.3% |
JG89 (129A/G) | 5 | 100 | 38.1 | 54.4% |
JG121 (134E/S) | 5 | 100 | 26.7 | 68.0% |
JG135 (151Q/N) | 5 | 100 | 36.0 | 56.9% |
JG164 (163P/K) | 5 | 100 | 25.0 | 70.1% |
JG175 (189K/R) | 5 | 100 | 37.1 | 55.6% |
JG196 (134E/S和 80N/W) | 5 | 100 | 27.8 | 66.7% |
JG217 (217R/ T) | 5 | 100 | 38.6 | 53.8% |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610017406.XA CN105481963B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg50及其应用 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610017406.XA CN105481963B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg50及其应用 |
CN201410249736.2A CN104031136B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体及其应用 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410249736.2A Division CN104031136B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105481963A CN105481963A (zh) | 2016-04-13 |
CN105481963B true CN105481963B (zh) | 2019-08-16 |
Family
ID=51462152
Family Applications (16)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610017406.XA Expired - Fee Related CN105481963B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg50及其应用 |
CN201610017473.1A Active CN105461792B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg164及其应用 |
CN201610017442.6A Active CN105418752B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg89及其应用 |
CN201610017414.4A Active CN105481965B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg63及其应用 |
CN201610017419.7A Active CN105440118B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg70及其应用 |
CN201610017410.6A Active CN105481964B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg60及其应用 |
CN201610017401.7A Pending CN105541984A (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg36及其应用 |
CN201610037005.0A Active CN105481967B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg16及其应用 |
CN201610017478.4A Active CN105418753B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg217及其应用 |
CN201610017470.8A Expired - Fee Related CN105418742B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg135及其应用 |
CN201610017459.1A Active CN105541985B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg121及其应用 |
CN201610017404.0A Active CN105481962B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg42及其应用 |
CN201410249736.2A Expired - Fee Related CN104031136B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体及其应用 |
CN201610017393.6A Pending CN105481961A (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg23及其应用 |
CN201610017475.0A Active CN105481966B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg175及其应用 |
CN201610017409.3A Active CN105440117B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg55及其应用 |
Family Applications After (15)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610017473.1A Active CN105461792B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg164及其应用 |
CN201610017442.6A Active CN105418752B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg89及其应用 |
CN201610017414.4A Active CN105481965B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg63及其应用 |
CN201610017419.7A Active CN105440118B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg70及其应用 |
CN201610017410.6A Active CN105481964B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg60及其应用 |
CN201610017401.7A Pending CN105541984A (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg36及其应用 |
CN201610037005.0A Active CN105481967B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg16及其应用 |
CN201610017478.4A Active CN105418753B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg217及其应用 |
CN201610017470.8A Expired - Fee Related CN105418742B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg135及其应用 |
CN201610017459.1A Active CN105541985B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg121及其应用 |
CN201610017404.0A Active CN105481962B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg42及其应用 |
CN201410249736.2A Expired - Fee Related CN104031136B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体及其应用 |
CN201610017393.6A Pending CN105481961A (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg23及其应用 |
CN201610017475.0A Active CN105481966B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg175及其应用 |
CN201610017409.3A Active CN105440117B (zh) | 2014-06-06 | 2014-06-06 | 鳐血管生成抑制因子1功能区变体jg55及其应用 |
Country Status (1)
Country | Link |
---|---|
CN (16) | CN105481963B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104774898B (zh) * | 2015-04-24 | 2020-07-14 | 浙江海洋学院 | 金枪鱼暗色肉蛋白抗***多肽的用途 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101260151A (zh) * | 2007-03-05 | 2008-09-10 | 广东海洋大学 | 鳐血管生成抑制因子1的分离、一级结构及其用于制备抑制血管生成和防治肿瘤药物的用途 |
CN101724631A (zh) * | 2008-11-03 | 2010-06-09 | 广东海洋大学 | 鳐血管生成抑制因子1功能区的制备及在防治肿瘤药物中的应用 |
CN102167725A (zh) * | 2010-12-07 | 2011-08-31 | 浙江海洋学院 | 一种孔鳐血管生成抑制因子rcaif-i的制备方法 |
-
2014
- 2014-06-06 CN CN201610017406.XA patent/CN105481963B/zh not_active Expired - Fee Related
- 2014-06-06 CN CN201610017473.1A patent/CN105461792B/zh active Active
- 2014-06-06 CN CN201610017442.6A patent/CN105418752B/zh active Active
- 2014-06-06 CN CN201610017414.4A patent/CN105481965B/zh active Active
- 2014-06-06 CN CN201610017419.7A patent/CN105440118B/zh active Active
- 2014-06-06 CN CN201610017410.6A patent/CN105481964B/zh active Active
- 2014-06-06 CN CN201610017401.7A patent/CN105541984A/zh active Pending
- 2014-06-06 CN CN201610037005.0A patent/CN105481967B/zh active Active
- 2014-06-06 CN CN201610017478.4A patent/CN105418753B/zh active Active
- 2014-06-06 CN CN201610017470.8A patent/CN105418742B/zh not_active Expired - Fee Related
- 2014-06-06 CN CN201610017459.1A patent/CN105541985B/zh active Active
- 2014-06-06 CN CN201610017404.0A patent/CN105481962B/zh active Active
- 2014-06-06 CN CN201410249736.2A patent/CN104031136B/zh not_active Expired - Fee Related
- 2014-06-06 CN CN201610017393.6A patent/CN105481961A/zh active Pending
- 2014-06-06 CN CN201610017475.0A patent/CN105481966B/zh active Active
- 2014-06-06 CN CN201610017409.3A patent/CN105440117B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101260151A (zh) * | 2007-03-05 | 2008-09-10 | 广东海洋大学 | 鳐血管生成抑制因子1的分离、一级结构及其用于制备抑制血管生成和防治肿瘤药物的用途 |
CN101724631A (zh) * | 2008-11-03 | 2010-06-09 | 广东海洋大学 | 鳐血管生成抑制因子1功能区的制备及在防治肿瘤药物中的应用 |
CN102167725A (zh) * | 2010-12-07 | 2011-08-31 | 浙江海洋学院 | 一种孔鳐血管生成抑制因子rcaif-i的制备方法 |
Non-Patent Citations (2)
Title |
---|
血管生成抑制因子抗癌研究进展;苏东晓等;《海南大学学报自然科学版》;20091231;第27卷(第3期);第297-301页 * |
赤魟软骨血管生成抑制因子的纯化及抗血管生成活性验证;罗红宇等;《水产学报》;20071130;第31卷(第6期);第813-817页 * |
Also Published As
Publication number | Publication date |
---|---|
CN105418742A (zh) | 2016-03-23 |
CN105418752A (zh) | 2016-03-23 |
CN105481963A (zh) | 2016-04-13 |
CN105481962A (zh) | 2016-04-13 |
CN105481967B (zh) | 2019-08-13 |
CN105440117B (zh) | 2018-10-26 |
CN105440118B (zh) | 2018-10-16 |
CN105541984A (zh) | 2016-05-04 |
CN105461792B (zh) | 2019-08-20 |
CN105541985B (zh) | 2019-08-16 |
CN105440117A (zh) | 2016-03-30 |
CN105418753A (zh) | 2016-03-23 |
CN105481967A (zh) | 2016-04-13 |
CN105440118A (zh) | 2016-03-30 |
CN105481965B (zh) | 2019-04-26 |
CN104031136A (zh) | 2014-09-10 |
CN105418753B (zh) | 2018-12-21 |
CN105481966A (zh) | 2016-04-13 |
CN105481964A (zh) | 2016-04-13 |
CN105481966B (zh) | 2019-05-28 |
CN105418742B (zh) | 2018-12-25 |
CN104031136B (zh) | 2016-08-17 |
CN105461792A (zh) | 2016-04-06 |
CN105481962B (zh) | 2019-08-20 |
CN105481965A (zh) | 2016-04-13 |
CN105418752B (zh) | 2018-12-25 |
CN105541985A (zh) | 2016-05-04 |
CN105481961A (zh) | 2016-04-13 |
CN105481964B (zh) | 2018-10-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105481963B (zh) | 鳐血管生成抑制因子1功能区变体jg50及其应用 | |
CN105112391B (zh) | 一种人源精氨酸酶突变体及其制备方法和用途 | |
CN107488734B (zh) | miR-19a-3p在制备***癌骨转移诊断试剂和治疗药物中的应用 | |
CN113583095B (zh) | 抗肿瘤多肽及其用途 | |
CN104945490A (zh) | 分离的植物防御素多肽及其制备方法和在治疗肺癌中的用途 | |
CN109666064A (zh) | SALL4-RBBp4复合物阻断多肽和衍生抗肿瘤多肽及其应用 | |
CN104592353A (zh) | 一种抗肿瘤肽变体nc2及其应用 | |
CN104672303A (zh) | 一种抗肿瘤肽变体nc6及其应用 | |
CN106349371A (zh) | 人sfrp1变体及其应用 | |
CN106349372A (zh) | 人sfrp1变体及其应用 | |
CN106349368A (zh) | 人sfrp1变体及其应用 | |
CN106349369A (zh) | 人sfrp1变体及其应用 | |
CN106349370A (zh) | 人sfrp1变体及其应用 | |
CN106349367A (zh) | 人sfrp1变体及其应用 | |
CN106349373A (zh) | 人sfrp1变体及其应用 | |
CN106349379A (zh) | 人sfrp1变体及其应用 | |
CN106349376A (zh) | 人sfrp1变体及其应用 | |
CN106349377A (zh) | 人sfrp1变体及其应用 | |
CN104610428A (zh) | 一种抗肿瘤肽变体nc12及其应用 | |
CN104592355A (zh) | 一种抗肿瘤肽变体nc3及其应用 | |
CN104672305A (zh) | 一种抗肿瘤肽变体nc11及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20190703 Address after: 510030 Room 202, No. 13 Dongyuan Xincun, Yuexiu District, Guangzhou City, Guangdong Province Applicant after: Chen Size Applicant after: The First Affiliated Hospital of Guangdong Medical University Address before: 311200 Zhejiang Hangzhou Xiaoshan District North dry Street 48 yuan 3 yuan 201 rooms. Applicant before: Zhang Yong |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190816 Termination date: 20210606 |