CN105477350A

CN105477350A - Traditional Chinese medicine composition for treating pruritus due to liver diseases

Info

Publication number: CN105477350A
Application number: CN201610025769.8A
Authority: CN
Inventors: 王江军; 胥丹
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-15
Filing date: 2016-01-15
Publication date: 2016-04-13

Abstract

The invention relates to the field of drug formulation, in particular to a traditional Chinese medicine composition for treating pruritus due to liver diseases. The traditional Chinese medicine composition is characterized by being prepared from the following crude drugs in parts by weight: 9-12 parts of fructus kochiae, 6-9 parts of syzygium sanarangense, 2-5 parts of fructus xanthii, 3-9 parts of radix cynanchi atrati, 6-9 parts of dried tangerine peel, 6-9 parts of whitmania pigra whitman, 20-30 parts of fructus cnidii, 15-60 parts of artemisia argyi, 9-12 parts of vaccaria segetalis, 30-50 parts of herba agrimoniae, 6-9 parts of schefflera arboricola hayata, 3-10 parts of herba lagotis, 6-9 parts of evodia lepta, 15-30 parts of rosa multiflora, 3-9 parts of gentiana scabra, 3-6 parts of impatiens balsamina and 6-9 parts of linseed; the preparation method comprises the steps of adding water into the crude drugs for decocting, and removing the dregs to obtain the filtrate. The traditional Chinese medicine composition has the benefits of being low in cost, less in toxic and side effect, good in treating effect, and capable of treating both symptoms and root causes, treating both excess and deficiency, clearing heat, expelling damp, detoxifying, removing dampness and dredging collaterals.

Description

The Chinese medicine composition for the treatment of hepatopathy pruritus

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine composition for the treatment of hepatopathy pruritus.

Background technology

As everyone knows, skin pruritus a kind ofly only has skin pruritus and without the dermatosis of obvious primary lesion, although without obvious disease damage, but pruritus is not easily eradicated, and sometimes has a strong impact on work and the quality of life of patient.Multiple systemic disease can occur together pruritus, and hepatic disease is the most common.Pruritus occurs together in the hepatopathy of almost all kinds, and clinical manifestation is: obstinate pruritus, and sleeping and eating difficulty peace, anxiety is irritated, and attach most importance to night, the persistent period is long.Study for a long period of time and think that hepatopathy pruritus has following reason: sex hormone level declines, sebaceous gland hypofunction; Cerebral cortex irritability and the imbalance of suppression regulatory function; Cholestasis directly causes bilirubin and raises, hepatocyte injury, abnormal liver function; Metabolism obstacles of blood glucose etc.In recent years research thinks that obstinate pruritus is central, and in patients with chronic liver blood plasma, enkephalin class material increases, and brain strengthens the sensitivity of morphine.Research confirm: severe icterohepatitis more than 95% with blood stasis heat in blood for primary symptom.The traditional Chinese medical science is thought: heat in blood, blood stasis are the main causes causing skin pruritus, and pruritus belongs to " disease of itching " category, and the cause of disease is mostly accumulate in skin by damp and hot, or blood-deficiency leading to hyperactivity of the liver, raw dry, failure of skin and muscle to be nourished humorously or dampness-heat in the liver and gallbladder bet are held concurrently because of caused by retention of damp-heat in the interior.

Modern medicine, only for clinical a certain symptom treatment, adopts the treatment of jaundice eliminating, function of gallbladder promoting, only can make some patients remission, fall flat.Antipruriticly only take stopgap measures, it is basic for fundamentally making hepatopathy alleviate, curing.

Summary of the invention

Object of the present invention is exactly that provide the Chinese medicine composition of the treatment hepatopathy pruritus that a kind of cost is low, toxic and side effects is little, therapeutic effect is good, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, clearing heat and expelling damp, removing toxic substances, dampness removing dredging collateral in order to overcome above-mentioned existing technical deficiency.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine composition for the treatment of hepatopathy pruritus, it is characterized in that being made up of the crude drug of following weight portion: Fructus Kochiae 9-12, Eugenia javanica Lam root 6-9, Fructus Xanthii 2-5, Radix Cynanchi Atrati 3-9, Exocarpium Citri Rubrum 6-9, Hirudo 6-9, Fructus Cnidii 20-30, Folium Artemisiae Argyi 15-60, Semen Vaccariae 9-12, Herba Agrimoniae 30-50, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6-9, Radix Pecteilis susannae 3-10, Foliumet Ramulus Evodiae 6-9, Fructus rosae multiflorae 15-30, Radix Gentianae 3-9, Flos Impatientis 3-6, Semen Lini 6-9, above-mentioned raw materials medicine is added water and decocts, filtrate of removing slag to obtain.

The invention has the beneficial effects as follows, cost is low, toxic and side effects is little, therapeutic effect is good, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, clearing heat and expelling damp, removing toxic substances, dampness removing dredging collateral.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

The Fructus Kochiae, Eugenia javanica Lam root, Fructus Xanthii, Radix Cynanchi Atrati, Exocarpium Citri Rubrum, Hirudo, Fructus Cnidii, Folium Artemisiae Argyi, Semen Vaccariae, Herba Agrimoniae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Pecteilis susannae, Foliumet Ramulus Evodiae, Fructus rosae multiflorae, Radix Gentianae, Flos Impatientis, Semen Lini is adopted to be that raw material is prepared from, above-mentioned raw materials medicine is added water and decocts, filtrate of removing slag to obtain.Its component (weight portion) is often paid as the Fructus Kochiae 12, Eugenia javanica Lam root 9, Fructus Xanthii 5, Radix Cynanchi Atrati 9, Exocarpium Citri Rubrum 9, Hirudo 9, Fructus Cnidii 30, Folium Artemisiae Argyi 60, Semen Vaccariae 12, Herba Agrimoniae 50, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 9, Radix Pecteilis susannae 10, Foliumet Ramulus Evodiae 9, Fructus rosae multiflorae 30, Radix Gentianae 9, Flos Impatientis 6, Semen Lini 6.Getting above-mentioned 17 taste raw material gross weights is 216 grams, and add water about 1100ml, at room temperature soaks 3-4 hour, decoct to 40 minutes, remove slag to obtain filtrate 200ml, and medicinal residues add water 300ml again, decoct 30-40 minute, remove slag to obtain filtrate 100ml, is total to obtain about 300ml medicine juice, i.e. obtained decoction of the present invention, load in sterile glass vials, seal bottle cap is for subsequent use, and every day 1 dose point 2 times is oral, and 2 hours after meal oral.15 days is a course for the treatment of, takes and stops 2 days 1 course for the treatment of, then take next course for the treatment of, generally applies two courses for the treatment of.

Fructus Kochiae diarrhea of heat type of the present invention wets, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus; Eugenia javanica Lam root dampness removing, antipruritic, cure mainly dysuria, skin pruritus; Fructus Xanthii dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, pain relieving.For anemofrigid cold, nasal sinusitis, rheumatic arthralgia, the cards such as rubella pruritus; Radix Cynanchi Atrati has except fidgets due to deficiency, heat clearing away are loose swollen, the effect of granulation promoting pain relieving, can control dribbling urination, nephritis, urinary tract infection, edema, bronchitis and rheumatic lumbago and scelalgia etc.; Exocarpium Citri Rubrum gas alleviating distention in middle-JIAO, drying dampness to eliminate phlegm.For cough with copious phlegm, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed; Hirudo has the effect such as treatment apoplexy, hypertension, the clear stasis of blood, amenorrhea, traumatic injury; Fructus Cnidii warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; Folium Artemisiae Argyi has warming the meridian, dries, cold expelling, hemostasis, antiinflammatory, relieving asthma, cough-relieving, the effect such as antiabortive, antiallergic; Semen Vaccariae has promoting blood circulation to restore menstrual flow, and stimulating milk secretion is subsided a swelling, effect of inducing diuresis for treating stranguria syndrome.For amenorrhea, dysmenorrhea, agalactia, acute mastitis swells and ache, the puckery pain of stranguria; Herba Agrimoniae astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, control epistaxis and have specially good effect, malaria, de-power impairment caused by overstrain, carbuncle; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) has promoting the circulation of QI to relieve pain, promoting blood circulation and detumescence, the effects such as strengthening bone and muscle; Radix Pecteilis susannae expelling cold and relieving exterior syndrome, diuretic dehumidifies, removing toxic substances softening the hard mass, relieving convulsion; Foliumet Ramulus Evodiae heat-clearing and toxic substances removing, expelling wind and removing dampness.Control laryngopharynx swelling and pain, rheumatic ostalgia, malaria, jaundice, eczema, dermatitis; Fructus rosae multiflorae removing pathogenic heat from blood and toxic substance from the body, main carbuncle, malignant boil knot meat, falls muscle and loses skin ulcer, steam, the erosion of the vulva not recover, sharp joint; Radix Gentianae heat clearing and damp drying, eliminating pathogen in the liver is calmed the frightened.Jaundice due to damp-heat, urine leaching pain, swelling of the vulva pudendal pruritus, damp-heat vaginal discharge, the feeling of fullness in the head headache of liver and gall excess-fire; Flos Impatientis can be invigorated blood circulation relieving distension, controls traumatic injury; Blood viscosity falls in Semen Lini, reduces blood fat, prevention blood clotting and blood pressure lowering, anti-apoplexy and myocardial infarction, pulmonary infarction etc.

The each raw material of the present invention also can the embodiment that mixes of ratio (weight portion) listed by according to the form below realize.Its processing technique is identical with embodiment 1.

Embodiment	The Fructus Kochiae	Eugenia javanica Lam root	Fructus Xanthii	Radix Cynanchi Atrati	Exocarpium Citri Rubrum	Hirudo	Fructus Cnidii	Folium Artemisiae Argyi	Semen Vaccariae	Herba Agrimoniae	Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)	Radix Pecteilis susannae	Foliumet Ramulus Evodiae	Fructus rosae multiflorae	Radix Gentianae	Flos Impatientis	Semen Lini
																		Two	9	9	2	9	6	9	20	60	9	50	6	10	6	30	3	6	6
Three	12	6	5	3	9	6	30	15	12	30	9	3	9	15	9	3	9
																		Four	10	7	4	5	7	8	25	45	11	40	7	8	7	20	6	4	8

The clinical trial carried out below in conjunction with my institute is described in further detail the present invention:

Clinical data:

Hepatopathy pruritus patient totally 50 examples that in June, 2012 ~ 2014 year October is in hospital in my institute, man 32 example, female 18 example, 15 ~ 53 years old age.Diagnosis all meets lemology branches of Chinese Medical Association in 2006 and hepatopathy credit can combine revision " chronic hepatopathy guideline of prevention and treatment ", patient all has obvious skin pruritus (severe pruritus: because of pruritus impact sleep and daily life, skin has darker trace of scratching; Moderate pruritus: on sleep and daily life impact little, but need use hands scratch, skin trace of scratching is shallow; Slight pruritus: pruritus can be stood, slightly uses hands scratch sometimes, skin without trace of scratching, on sleep and daily life impact little, but need use hands scratch, skin trace of scratching is shallow); And get rid of the skin pruritus 1. merging erythra; 2. without the skin pruritus of erythra: comprise skin pruritus, various thigmic stimulus sexual factor, anaphylactic disease; 3. life span < 2 months persons are estimated.

Therapeutic Method:

Take embodiment one medicament, every day 1 dose point 2 times is oral, and 2 hours after meal oral.15 days is a course for the treatment of, takes and stops 2 days 1 course for the treatment of, then take next course for the treatment of, generally applies two courses for the treatment of.

The standard of curative effect evaluation:

Cure: liver function recovery is normal, and sign is improved completely, and patient is without pruritus.

Effective: without pruritis, or have slight pruritis, without the need to scratching, can stand, serum total bilirubin declines 1/2 ~ 2/3 than original, and jaundice obviously disappears.

Effective: to have pruritis, need scratch with hands, but without scratching trace, not affect life and sleep, serum total bilirubin declines 1/3 ~ 1/2 than original, and jaundice slightly alleviates.

Invalid: pruritis is without alleviating or increasing the weight of than originally, and serum total bilirubin raises than original.

Total effective rate is that healing adds effective and effective percentage sum.

Treat fruit: cure 38 examples, effective 7 examples, effective 3 examples, invalid 2 examples, total effective rate is 96%;

Model case:

Ma, man, 31 years old, weak, uncomfortable liver area 3 weeks, dim complexion, whole skin, yellow sclera, whole body was dispersed in scratch.Diagnosis: medicamentous liver lesion.Liver power checking: glutamic oxaloacetic transaminase, GOT AST:328U/L, glutamic oxaloacetic transaminase, GOT ALT:605U/L, Glutamyl transpeptidase GGT:291U/L, total bilirubin TBIL:98.51UMOL/L, direct DBIL:72.01UMOL/L, icteric index (serum bilirubin) 48umol, after taking a course for the treatment of of the embodiment of the present invention one Chinese medicine composition, spirit takes a turn for the better, whole skin, yellow sclera obviously disappears, continue to take a course for the treatment of, liver power checking: glutamic oxaloacetic transaminase, GOT AST:205U/L, glutamate pyruvate transaminase ALT:241U/L, Glutamyl transpeptidase GGT:83U/L, total bilirubin TBIL:17.42UMOL/L, bilirubin direct DBIL:12.11UMOL/L, icteric index (serum bilirubin) 14.1umol.Liver power checking all in normal range, without pruritis.

Normal certain, female, 40 years old, more than weak, poor appetite February, whole skin, sclera severe xanthochromia, uncomfortable liver area, abdominal distention was obvious, and night, pruritus was obvious, and prolonged sleep is less than 2 hours, and abdominal ultrasonic is looked into and shown: chronic hepatopathy, cystic polyp, slight splenomegaly.Diagnosis: cirrhosis patients in decompensation.Liver function: AST:565U/L, ALT:718U/L, Glutamyl transpeptidase GGT:360U/L, glutamte dehydrogenase: 17.7U/L, take the invention process one Chinese medicine composition, behind a course for the treatment of sky, spirit takes a turn for the better, skin, yellow sclera obviously disappear, continuous take a course for the treatment of of Chinese medicine composition of the present invention, liver function recovery is normal, and sign is improved completely, patient at night pruritus disappears, and prolonged sleep is greater than 6 hours.

Claims

1. treat the Chinese medicine composition of hepatopathy pruritus for one kind, it is characterized in that being made up of the crude drug of following weight portion: Fructus Kochiae 9-12, Eugenia javanica Lam root 6-9, Fructus Xanthii 2-5, Radix Cynanchi Atrati 3-9, Exocarpium Citri Rubrum 6-9, Hirudo 6-9, Fructus Cnidii 20-30, Folium Artemisiae Argyi 15-60, Semen Vaccariae 9-12, Herba Agrimoniae 30-50, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6-9, Radix Pecteilis susannae 3-10, Foliumet Ramulus Evodiae 6-9, Fructus rosae multiflorae 15-30, Radix Gentianae 3-9, Flos Impatientis 3-6, Semen Lini 6-9, above-mentioned raw materials medicine is added water and decocts, filtrate of removing slag to obtain.