CN105434930A - Preparation method of cesarean section postoperative oral drug - Google Patents

Preparation method of cesarean section postoperative oral drug Download PDF

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CN105434930A
CN105434930A CN201510949242.XA CN201510949242A CN105434930A CN 105434930 A CN105434930 A CN 105434930A CN 201510949242 A CN201510949242 A CN 201510949242A CN 105434930 A CN105434930 A CN 105434930A
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powder
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苗洁清
宋玲玲
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Abstract

The invention discloses a preparation method of a cesarean section postoperative oral drug, and is used for solving the problem of treatment of cesarean section postoperative gastrointestinal dysfunction. The preparation method is characterized by comprising the steps: (1) extracting volatile oil and drug dregs from stem of obtuseleaf erycibe, folium et ramulus clerodendri trichotomi and root of anglicaapaensis shanet yuan coarse powder for standby application; (2) steaming nostoc flagelliforme for 20 minutes, then drying and crushing into fine powder for standby application; (3) carrying out water extraction and alcohol precipitation of inflorescence of miscanthus sinensis anderss, root bark of chukrasia tabularis, leaf of chinese hibiscus, himalayan teasel root, tortoise shell and the drug dregs obtained in the step (1), and concentrating and drying the supernatant to obtain a dried extract powder; and (4) spraying the volatile oil to the dried extract powder, adding the nostoc flagelliforme fine powder, mixing evenly, passing through a 60 mesh sieve, and packing in capsules to obtain the product. Clinical experiments prove that the drug is used after cesarean section and has the characteristics of good curative effect and higher safety.

Description

A kind of preparation method of cesarean postoperate oral drugs
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of preparation method of cesarean postoperate oral drugs.
Background technology
Cesarean esction refers to take out the operation of fetus through abdominal incision uterus, is important in obstetrics and common surgical, has become and solved difficult labour and some obstetrics' complication, saved the effective means of puerpera and peri-natal infant life.
Cesarean postoperate functional dyspepsia is cesarean postoperate common complication, and some patients's serious symptom or lasting, has a strong impact on its quality of life.Its clinical manifestation mostly is post-operation diarrhea and constipation alternately occurs, diarrhoea shows as noninfectious diarrhea, and diarrhea, amount is many, color is shallow lightly seasoned.Occurrence cause there is no unhygienic diet or intolerance factors, research in recent years shows, this kind puerperal/a part of mechanical stretch be for abdominal cavity intestinal tube internal organs in cesarean section of reason that alternately occurs with constipation of cesarean postoperate diarrhoea, but the puerpera of same spontaneous labor some also there will be above-mentioned symptom, therefore inference, the hormonal readiness in puerperium body is divided to change rapidly, body autonomic nerve disorder, intestinal mucosa is corresponding is in the state of high stress malabsorption, find expression in the absorption of fat disorderly more, it is bad to fat absorption that some patients shows as little intestinal segment, cause colorectum content fat content too high, stimulate the next intestinal cramps, produce diarrhoea, and another part patients to be little intestinal segment excessive to fat absorption, cause colorectum content fat content too low, feces skids off obstacle, furthermore puerperal, abdominal muscle muscular strength declined, and cause difficult defecation.Diarrhoea does not exist merely with constipation symptom, but the reason alternately occurred just is that intestinal mucosa capacity of self-regulation is lost, and food or the slight change of medication, namely break original balance, initiation symptom variation.So, the medication of cesarean postoperate functional dyspepsia also becomes difficult point, then can cause constipation with relieving diarrhea with astringents medicine (as montmorillonite powder etc.), then can cause diarrhoea with loosening bowel to relieve constipation medicine (as MAREN RUNCHANG WAN), it also can cause baby's gastrointestinal dysfunction for puerpera's age of sucking.Therefore, alleviate intestinal mucosa the state of high stress, stablize little intestinal segment fat absorption, be only the basic place for the treatment of.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the preparation method of the little a kind of cesarean postoperate oral drugs of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of preparation method of cesarean postoperate oral drugs, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts, awns, numb chinaberry 3 ~ 12 parts, native Rhizoma Chuanxiong 3 ~ 12 parts, Folium et Ramulus Clerodendri Trichotomi 12 ~ 20 parts, Caulis Erycibes 12 ~ 20 parts, Folium Hibisci Rosae-Sinensis 12 ~ 20 parts, Radix Dipsaci 12 ~ 20 parts, Carapax Et Plastrum Testudinis 3 ~ 12 parts, deliver vegetables 10 ~ 25 parts.
Chinese medicine of the present invention can be prepared from by following method:
(1) Caulis Erycibes, Folium et Ramulus Clerodendri Trichotomi, native Rhizoma Chuanxiong coarse powder are extracted volatile oil with vapor distillation respectively for subsequent use, and it is for subsequent use to collect medicinal residues;
(2) will deliver vegetables after cleaning and steam 20 minutes, dry after taking out, pulverized 150 mesh sieves, become fine powder for subsequent use;
(3) awns, numb chinaberry, Folium Hibisci Rosae-Sinensis, Radix Dipsaci, Carapax Et Plastrum Testudinis and the mixing of step (1) gained medicinal residues are added 8 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 15 minutes, get supernatant, at recovery ethanol disease is concentrated into relative density 1.28 ~ 1.30(60 DEG C), drying under reduced pressure is also pulverized, and get dry extract powder;
(4) gained volatile oil in step (1) is sprayed in step (3) gained dried cream powder, add gained fine powder mixing in step (2), cross 60 mesh sieves, encapsulatedly to form.
Wherein said: awns is the inflorescence of grass awns MiscanthussinensisAnderss..Nature and flavor are sweet; Flat.Function cures mainly: promoting blood circulation to restore menstrual flow.Fiber crops chinaberry is the root bark of Meliaceae plant fiber crops chinaberry ChukrasiatabularisA.Juss.Nature and flavor are bitter; Cold.Function cures mainly: wind and heat dispersing.Soil Rhizoma Chuanxiong is the root of samphire Aba Radix Angelicae Sinensis AnglicaapaensisShanetYuan.Acrid in the mouth; Bitter; Warm in nature.Return spleen; Liver; Lung meridian.Function cures mainly: regulating QI to relieve pain; Relieving cough and asthma.Folium et Ramulus Clerodendri Trichotomi, is Verbena officinalis Ke Cheng paulownia platymiscium clerodendron trichotomum ClerodendrontrichotomumThunb., is used as medicine with root, stem, leaf.Taste bitter, sweet, flat.Merit can remove rheumatism, blood pressure lowering.Caulis Erycibes is the dry rattan of convolvulaceous plant Caulis Erycibes ErycibeobtusfoliaBenth. or erycibe schmidtii Craib Erycibesch-midtiiCraib.Acrid in the mouth, temperature.Return liver, spleen, stomach warp.Merit can expelling wind and removing dampness, reducing swelling and alleviating pain.Folium Hibisci Rosae-Sinensis is the leaf of Malvaceae plant Hibiscus rosasinensis Hibiscusrosa-sinensisL..Sweet in the mouth; Light; Property is put down.GUIXIN; Liver Channel.Function cures mainly: the diarrhea of heat type that disappears wets; Removing toxic substances.Radix Dipsaci is the dry root of Dipsacaceae herbaceos perennial Radix Dipsaci HimalayanTeaselRoot.Bitter in the mouth is pungent; Slightly warm in nature.Return liver, kidney channel.Merit can invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.Carapax Et Plastrum Testudinis is Testudinidae animal Testudinis Chinemysreevesii(Gray) carapace and sternite.Nature and flavor are salty, sweet, are slightly cold.Return liver, kidney, heart channel.Merit can nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood.Deliver vegetables, for nostocaceae plant is delivered vegetables the frond of NostocflagelliformeBorn.etFlah..Function cures mainly: enrich blood; Diuretic antihypertensive; Preventing phlegm from forming and stopping coughing.
In prior art, the diarrhoea alternately occurred for cesarean postoperate and constipation therapy mostly are symptomatic treatment, but its pathogenic factors part is the mechanical stretch for abdominal cavity intestinal tube internal organs in cesarean section, another part is that the hormonal readiness in point puerperium body changes rapidly, body autonomic nerve disorder, intestinal mucosa is corresponding is in the state of high stress and secondary malabsorption, especially disorderly to the absorption of fat.And diarrhoea and constipation symptom do not exist merely, but alternately occur, so this cesarean postoperate functional dyspepsia symptomatic treatment, as can constipation be caused with relieving diarrhea with astringents medicine (as montmorillonite powder etc.) is then many, then diarrhoea can be caused with loosening bowel to relieve constipation medicine (as MAREN RUNCHANG WAN), it also can cause baby's gastrointestinal dysfunction for puerpera's age of sucking.
Compared with prior art, the present invention has following characteristics:
1, prescription does not use the medicine of relieving diarrhea with astringents or loosening bowel to relieve constipation, treatment must aim at the pathogenesis of disease, based on alleviation intestinal mucosa the state of high stress, stablizes little intestinal segment fat absorption.
2, get awns in side, numb chinaberry is monarch, this medicine is to effect of dredging collateral dispelling wind, after entering small intestinal, act on mucous membrane of small intestine, by reducing the state of high stress, increase intestinal absorption ability, awns, numb chinaberry (3:1) mixing water extract animal pharmacological experiment confirm: 1. can raise abdominal postoperative Wistar rat small intestine malabsorption model mucous membrane of small intestine HSP70mRNA transcriptional expression peak value, and promote that it falls after rise as early as possible, reduce subsequent stimuli (the medication 3d: experimental group 0.897 ± 0.041 is higher than model group 0.686 ± 0.025 that stress bring; Medication 7d: experimental group 0.283 ± 0.033 is lower than model group 0.519 ± 0.026, and difference all has statistical significance, P<0.05); 2. dual regulation is had to the kinestate of family's rabbits infestines, i.e. the obvious ileum spasm that Ileum activity suppresses and acetylcholine causes that causes of antagonism epinephrine.
3, auxiliary regulating qi and dredging collateral effect is played in native Rhizoma Chuanxiong, Folium et Ramulus Clerodendri Trichotomi cooperation, and the total coumarin of native Rhizoma Chuanxiong is to rabbit, and in vitro or original position small intestinal has spasmolysis, and Folium et Ramulus Clerodendri Trichotomi has enhancing intestinal smooth muscle tensity and position phasic contractions function, soil Rhizoma Chuanxiong, both Folium et Ramulus Clerodendri Trichotomis opposite effect phase interworking and, run well helpful for recovery intestinal smooth in puerperal, relaxation has and can not increase gastrointestinal burden, and native Rhizoma Chuanxiong, Folium et Ramulus Clerodendri Trichotomi all without obvious effect, show that medicine can not affect recover of uterus in puerperal to isolated rat, Rabbit Uterus.
4, Caulis Erycibes, Folium Hibisci Rosae-Sinensis play the effect of dampness removing, the pungent temperature of Caulis Erycibes, and Folium Hibisci Rosae-Sinensis is put down, and has the merit of heat reliving and toxin-eliminating, and the two coordinates the anxiety without warm-dryness syndrome, are particularly suitable for use in puerperal.
5, Radix Dipsaci, Carapax Et Plastrum Testudinis conception are to alleviate puerperal floating sun and rise, and gas is not descending, affect the operation of intestinal mechanism of qi, and defecation inability or retrain unable.
6, deliver vegetables for the protection of intestinal mucosa.
7, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: awns 20g, numb chinaberry 6g, native Rhizoma Chuanxiong 12g, Folium et Ramulus Clerodendri Trichotomi 15g, Caulis Erycibes 15g, Folium Hibisci Rosae-Sinensis 15g, Radix Dipsaci 15g, Carapax Et Plastrum Testudinis 12g, deliver vegetables 20g.
The preparation method of embodiment 1 is: awns, Folium Hibisci Rosae-Sinensis, numb chinaberry, native Rhizoma Chuanxiong, Folium et Ramulus Clerodendri Trichotomi, Caulis Erycibes, Radix Dipsaci, Carapax Et Plastrum Testudinis, mixing and water adding of delivering vegetables are decocted, filtrate is got after 30 minutes, medicinal residues add water and continue decoction and get filtrate after 20 minutes, and twice filtrate merges, and are divided into two parts of morning and evenings to take.
Embodiment 2, crude drug weight proportion: 10 parts, awns, numb chinaberry 3 parts, native Rhizoma Chuanxiong 3 parts, Folium et Ramulus Clerodendri Trichotomi 12 parts, Caulis Erycibes 12 parts, Folium Hibisci Rosae-Sinensis 12 parts, Radix Dipsaci 12 parts, Carapax Et Plastrum Testudinis 12 parts, deliver vegetables 10 parts.
Embodiment 3, crude drug weight proportion: 20 parts, awns, numb chinaberry 6 parts, native Rhizoma Chuanxiong 12 parts, Folium et Ramulus Clerodendri Trichotomi 15 parts, Caulis Erycibes 15 parts, Folium Hibisci Rosae-Sinensis 15 parts, Radix Dipsaci 15 parts, Carapax Et Plastrum Testudinis 12 parts, deliver vegetables 20 parts.
Embodiment 4, crude drug weight proportion: 30 parts, awns, numb chinaberry 12 parts, native Rhizoma Chuanxiong 6 parts, Folium et Ramulus Clerodendri Trichotomi 20 parts, Caulis Erycibes 20 parts, Folium Hibisci Rosae-Sinensis 20 parts, Radix Dipsaci 20 parts, Carapax Et Plastrum Testudinis 3 parts, deliver vegetables 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Caulis Erycibes, Folium et Ramulus Clerodendri Trichotomi, native Rhizoma Chuanxiong coarse powder are extracted volatile oil with vapor distillation respectively for subsequent use, and it is for subsequent use to collect medicinal residues;
(2) will deliver vegetables after cleaning and steam 20 minutes, dry after taking out, pulverized 150 mesh sieves, become fine powder for subsequent use;
(3) awns, numb chinaberry, Folium Hibisci Rosae-Sinensis, Radix Dipsaci, Carapax Et Plastrum Testudinis and the mixing of step (1) gained medicinal residues are added 8 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 15 minutes, get supernatant, at recovery ethanol disease is concentrated into relative density 1.28 ~ 1.30(60 DEG C), drying under reduced pressure is also pulverized, and get dry extract powder;
(4) gained volatile oil in step (1) is sprayed in step (3) gained dried cream powder, add gained fine powder mixing in step (2), cross 60 mesh sieves, encapsulatedly to form.
Every daily dose is equivalent to crude drug amount 130g/d, is divided into and takes for 2 ~ 3 times.
The efficient combination of said medicine, coordinates mutually, effectively reach the object for cesarean postoperate use, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: in January, 2014 ~ 2015 mature parturient after undergoing caesarean section in year May, and in one week, there is the diarrhoea (defecation frequency > 3 times every day) without infective agent or constipation (infrequent defecation > 3 days) 200 example, age, the mean age was 28.1 years old between 22 ~ 41 years old.Wherein primipara 122 example, multipara 78 example.And get rid of the organic disease such as digestive tract and liver, gallbladder, pancreas, spleen, kidney.And diarrhea patient need assist stool microscopy, just cultivate eliminating infectious diarrhea.
1.1.2 divide into groups: be divided into matched group 67 example, decoction group 66 example and Capsules group 67 example.Compare on age and childbirth base case before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 Therapeutic Method matched group gives symptomatic treatment: diarrhea patient fluid infusion, and as defecation frequency > every day then gives Smectite Powder treatment for 5 times, constipation patient gives oral hemp intestine-moistening pill for curing; It is oral that decoction group gives gained decoction in the embodiment of the present invention 1, every day twice; Capsules group gives gained capsule for treating in the embodiment of the present invention 3.Observe the curative effect after treatment 14d.
1.2.2 observation index: record clinical symptoms, complication and medication related reactions.
1.2.3 curative effect determinate standard: " new drug (Chinese medicine) efficacy assessment standard " issued with reference to State Administration of Traditional Chinese Medicine is formulated, and cures: times of defecation and character, symptom and sign recover normal completely; Effective: stool abnormity number of times is obviously alleviated (diarrhea frequency or constipation defecating interval are reduced to 1/2 before treatment or following), and character takes a turn for the better, and symptom, sign are obviously improved; Effective: stool abnormity number of times, character, symptom, sign make moderate progress; Invalid: symptom, sign have no improvement, or there is diarrhoea, constipation conversion.
1.2.4 statistical analysis: SPSS18.0 carries out statistical analysis.Measurement data t checks, enumeration data χ 2inspection.
2 results.
Comprehensive Clinical comparitive study after 2.1 3 groups for the treatment of 14d, sees the following form:
Group Number of cases Cure Effective Effectively Invalid Total effective rate
Matched group 67 8 25 18 16 76.12%
Decoction group 66 21 14 25 6 90.91%
Capsules group 67 25 12 26 4 94.03%
After treatment 14d, decoction group, Capsules group total effective rate and matched group compare, and have notable statistics difference (χ 2=5.27, P < 0.05; χ 2=8.46, P<0.01), and three groups of cure rates are respectively 11.94%, 31.82%, 37.31%, compare between group, difference is (χ very obviously 2=7.71, P < 0.01; χ 2=11.62, P<0.01).The medicine that two kinds of detailed description of the invention of proved invention prescription are obtained effectively can treat cesarean postoperate function of intestinal canal sexual disorder.
2.2 baby's untoward reaction are compared: three groups of puerperas are breast feeding, matched group, decoction group, Capsules group period in a medicine occur that the incidence rate of the non-lactose intolerance stool abnormity of baby is respectively 13.43%(9/67), 3.03%(2/66), 2.99%(2/67), two experimental grouies are starkly lower than matched group, (χ 2=4.52, P<0.05; χ 2=4.85, P<0.05), confirm thus, the medicine of two experimental grouies on the impact of breast feeding babies lower than matched group symptomatic treatment.
2.3 puerpera's untoward reaction and tolerations: in drug treatment process, three groups are and occur obvious adverse reaction, and before and after treatment, the conventional and hepatic and renal function of hematuria is without significant change.
3. conclusion.
This result of study shows, the decoction group of medicine of the present invention and Capsules group cure rate and total effective rate is used obviously to be better than matched group, and the side effect of digestive tract incidence rate of breast feeding babies is far below matched group, illustrate that medicine prepared by the inventive method has the advantage that curative effect is affirmed, safety is higher in treatment cesarean postoperate function of intestinal canal sexual disorder.

Claims (1)

1. a preparation method for cesarean postoperate oral drugs, is characterized in that, its crude drug is awns, Folium Hibisci Rosae-Sinensis, numb chinaberry, native Rhizoma Chuanxiong, Folium et Ramulus Clerodendri Trichotomi, Caulis Erycibes, Radix Dipsaci, Carapax Et Plastrum Testudinis, deliver vegetables; Preparation method is:
(1) Caulis Erycibes, Folium et Ramulus Clerodendri Trichotomi, native Rhizoma Chuanxiong coarse powder are extracted volatile oil with vapor distillation respectively for subsequent use, and it is for subsequent use to collect medicinal residues;
(2) will deliver vegetables after cleaning and steam 20 minutes, dry after taking out, pulverized 150 mesh sieves, become fine powder for subsequent use;
(3) awns, numb chinaberry, Folium Hibisci Rosae-Sinensis, Radix Dipsaci, Carapax Et Plastrum Testudinis and the mixing of step (1) gained medicinal residues are added 8 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 15 minutes, get supernatant, at recovery ethanol disease is concentrated into relative density 1.28 ~ 1.30(60 DEG C), drying under reduced pressure is also pulverized, and get dry extract powder;
(4) gained volatile oil in step (1) is sprayed in step (3) gained dried cream powder, add gained fine powder mixing in step (2), cross 60 mesh sieves, encapsulatedly to form.
CN201510949242.XA 2015-12-18 2015-12-18 Preparation method of cesarean section postoperative oral drug Pending CN105434930A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105106771A (en) * 2015-09-18 2015-12-02 韩淑臻 Medicine for recovery of puerperae subjected to caesarean birth operations and preparation method of medicine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105106771A (en) * 2015-09-18 2015-12-02 韩淑臻 Medicine for recovery of puerperae subjected to caesarean birth operations and preparation method of medicine

Non-Patent Citations (1)

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Title
王渭川: "《王渭川疑难病症治验选》", 31 January 1984, 四川科学技术文献出版社 *

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