CN105412030A - White staphylococcus tablet for relieving cough and preparation technology thereof - Google Patents
White staphylococcus tablet for relieving cough and preparation technology thereof Download PDFInfo
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- CN105412030A CN105412030A CN201510879039.XA CN201510879039A CN105412030A CN 105412030 A CN105412030 A CN 105412030A CN 201510879039 A CN201510879039 A CN 201510879039A CN 105412030 A CN105412030 A CN 105412030A
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Abstract
The invention relates to a white staphylococcus tablet for relieving a cough. The white staphylococcus tablet is prepared from 40 g of white staphylococcus powder, 25 g of dextrin, 35 g of 70% syrup, 5 g of starch and 0.28 g of magnesium stearate. 1000 tablets are prepared through a conventional method. The tablet has the coordination effect and is low in cost, and clinical verifications show that the tablet has the good treatment effect on cough and asthma.
Description
Technical field
The invention belongs to Chinese medicine technical field, concrete, relate to a kind of White staphylococcus tablet for cough-relieving and preparation technology thereof.
Background technology
Cough is one of modal symptom of respiratory system disease, is the protectiveness respiratory reflex action that human body removes secretions in respiratory tract or foreign body.A lot of reasons can cause cough, as Foreign body aspiration, upper respiratory tract infection, bronchitis, pneumonia and acute laryngitis etc.Usually with the disease such as heating, chest pain, dyspnea, spitting of blood, a large amount of thick sputum, wheezing sound, drumstick finger during coughing fit.The traditional Chinese medical science is thought, cough is divided into exogenous cough and endogenous cough.Exogenous cough refers to the cough caused by being invaded by exogenous pathogen, and exogenous cough is divided into cough due to wind and cold, cough due to pathogenic wind-heat, wind-dryness cough and xeropulmonary cough.Endogenous cough is that endogenous cough can be divided into phlegm dampness in lungs, expectorant heat stagnation lung, liver-fire invading the lung and syndrome of deficiency of lung yin caused by visceral dysfunction, the dry lung of interior heresy.
At present, treat cough and be divided into doctor trained in Western medicine and the traditional Chinese medical science two kinds of therapeutic modalities.Western medical treatment cough, mainly based on antiinflammatory, as the cough caused of catching a cold, except using antiviral to cure cold, also uses antibiotic; The cough caused because of rhinitis, sinusitis, tonsillitis etc. is with caused by trachea concurrent infection mostly, and therefore during treatment, many meetings carry out topical therapeutic for naso-pharynageal disease.The traditional Chinese medical science is mainly different with the cause of disease of endogenous cough according to exogenous cough, takes different therapeutic modalities.Although Western medicine can treat cough, can not improve and nurse one's health respiratory tract function, and take Western medicine for a long time and also can cause Drug resistance, cause cough again outbreak time can not obtain medical treatment.
China's Chinese medicine is thought: " lung governing qi, department breathes "." gas " mentioned here, refers to the gas of breathing on the one hand, refers to that lung and other internal organs show the function of breathing aspect on the one hand." lung opening at nose and throat, outer conjunction fur "." Plain Questions. cough opinion " say: " fur person, also, fur is first by pathogen, and pathogen is to close also from it in the conjunction of lung ", what say is that lung is communicated with the external world by nasopharynx part and skin hair key, just as one barrier, and the defensive enginery of supervisor's human body.Asthma attack seasonal pathogen is contained in lung, but the root of disease is then relevant with kidney and spleen, this is because lung governing qi and take charge of breathing, but the basis of gas is at kidney, suffering from a deficiency of the kidney then can not improving inspiration by invigorating kidney-QI, causes purgation gas to join not normal, << Lei Zheng Zhi Cai >> alleged " the lung being the dominator of QI; the kidney being the root of QI, lung master give vent to anger, kidney governing inspiration; negative and positive intersect; breathing be and, if cashier's abnormal ascending-descending of QI, here this breathes heavily work." describe " and lung governing qi, kidney improving inspiration by invigorating kidney-QI, gas for lung root in kidney " lung kidney between substantial connection, also can common deficiency of kidney-QI person to the dialectical of asthmatic patient.Lung is " device of storage expectorant ", and spleen is " the source of producing phlegm ", if dysfunction of the spleen in transportation, then poly-liquid becomes expectorant, on hinder and cause asthma in lung, << card controls gains in depth of comprehension >> cloud: " the lung being the dominator of QI, spleen then lung mother also; spleen lung has the deficiency that thanks to then gasifies, and deficiency is then very brief and breathe heavily." especially there is prior effect with the prosperity and decline of kidney qi in the advance and retreat of asthma in spleen kidney.
Motherland's medical science have accumulated rich experience in treatment bronchus cough with asthma.In medical practice, in general, the traditional Chinese medical science cure the disease effective, substantially have no side effect.Therefore continue to excavate Chinese material medicine resource, from natural drug, find effective, safe drugs, be the important directions of clinical treatment infantile asthma.
Summary of the invention
The object of the present invention is to provide a kind of White staphylococcus tablet for cough-relieving and preparation technology thereof.Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is the core theory of Chinese medicine disease always, how to take into account secondary pathogenesis for main pathogenesis medication simultaneously, taking into account the treatment of general character and individual character, thus at utmost embody intension and the extension of Chinese traditional treatment disease, is a realistic problem of Chinese patent medicine compatibility.The traditional Chinese medical science is thought, cough is the impairment of dispersing and descending function of the lung caused by exopathogen infringement lungs or visceral dysfunction, abnormal rising of lung-QI.From modern medical theory, cough as a kind of important defense mechanism, the pharyngeal and whole viscous secretion of respiratory tract and the harmful substance of suction and foreign body can be removed by cough.From physiology, coughing to the scavenging action of air flue is useful when excess secretion, and frequently violent cough can affect the breathing of patient and the function of heart.Very long history development procedure be experienced by the understanding of " cough ", " ten cough " from " visceral cough " of "Nei Jing" to Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases ", i.e. wind, cold, , the heart, liver, spleen, kidney, gallbladder, faint and to cough etc. ten kinds: from Au element to cough pathogenesis and Coryza Treated by Syndrome Differentiation, period of Ming and Qing are with Wang Kentang, Zhao Xianke is that the doctor of representative is to the further investigated of cough etiology and pathogenesis, to modern Application high-tech means to cough physiology and pathomechanism profound level dissect, and by means of the new experimental apparatus emerged in an endless stream and experimental technique, then more deep to its research, thoroughly.
Applicant is for cough main pathogenesis characteristics, in conjunction with a large amount of secret recipe according to doctor's row practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, and combine through test for many years, multiple formulations is screened, have found lower Chinese medicine composition exogenous cough and upper respiratory tract infection and bronchitis being had to better therapeutic effect that cooperatively interacts.Choose appropriate Chinese medicine ingredients from a large amount of natural prescription kind, require neither should cause stimulation, the effect of can play peace and quiet again, relievining asthma, relative to Western medicine, tablet of the present invention is rapid-action, effect is strong, short treating period, safety are high, without obvious toxic-side effects.
For realizing the object of the invention, the technical solution used in the present invention is as follows:
For White staphylococcus sheet and the preparation technology thereof of cough-relieving, it is prepared by following raw material and obtains:
White staphylococcus powder 40g, dextrin 25g, 70% syrup (weight ratio) 35g, starch 5g, magnesium stearate 0.28g.
Get above-mentioned raw materials, conventionally pelletize, prepare 1000, tablet.
Preferably, the present invention is used for the White staphylococcus sheet of cough-relieving, and it is prepared by following raw material and obtains:
White staphylococcus powder 40g, Chinese medicine powder 20g, dextrin 25g, 70% syrup (weight ratio) 35g, starch 5g, magnesium stearate 0.28g.
Get above-mentioned raw materials, conventionally pelletize, prepare 1000, tablet.
Described Chinese medicine powder, prepared by the raw material of following weight and obtain:
Fructus Schisandrae Chinensis 40 parts, Herba Lysionoti Pauciflori 38 parts, Semen Juglandis 38 parts, Radix Platycodonis 38 parts, Semen Coicis 35 parts,
Radix Polygalae 35 parts, Olibanum 30 parts, Radix Isatidis 30 parts, 30 parts, Herba Ephedrae, 25 parts, Poria,
Herba Taraxaci 25 parts, Fructus Ligustri Lucidi 25 parts, Folium Ginkgo 20 parts, Rhizoma Dioscoreae 20 parts, Fructus Momordicae 20 parts,
Folium Perillae 15 parts, the Radix Stemonae 15 parts, Herba Schizonepetae 15 parts, Radix Ophiopogonis 10 parts, 10 parts, Radix Glycyrrhizae,
Ramulus Cinnamomi 10 parts, Fructus Crataegi 10 parts, Semen Plantaginis 10 parts, 10 parts, Folium Mori, Fructus Lycii 10 parts, Herba Lycopi 10 parts.
The preparation method of described Chinese medicine powder is as follows:
(1) above-mentioned raw materials is taken for subsequent use
(2) get Semen Juglandis, Radix Platycodonis, Radix Glycyrrhizae, Ramulus Cinnamomi, Fructus Crataegi pulverized 100 mesh sieves, mix homogeneously, prepare complex A;
(3) get Herba Lysionoti Pauciflori, Semen Coicis, Olibanum, Poria, Rhizoma Dioscoreae, the Radix Stemonae, Radix Ophiopogonis decoct with water, first time adds 5 times of weight water, decoct 1 hour, obtain filtrate and medicinal residues after filtration, medicinal residues are added 3 times of weight water and decoct half an hour, after filtration, obtain filtrate, merge twice filtrate, filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtain complex B;
(4) get surplus stock and add 2 times of weight 75%(volume ratios) ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverized and obtained complex C;
(5) namely Homogeneous phase mixing complex A, B, C obtain Chinese medicine powder.
Crude drug White staphylococcus powder (PowderedStaphylococcusAlbus) of the present invention is yellowish-brown powder; Be similar to yeast smelly, tasteless, loss on drying≤7.0%, heavy metal≤0.002%, arsenic salt≤0.0002, must not calculate with organophosphor containing wall phosphoric acid matter and is less than 2.0%, meet national drug Western medicine standard (chemical drugs terrestrial reference rises GB the 16th) numbering WSI-XG-136-2002.By commercially available acquisition.
Medicine of the present invention can adopt the conventional method in existing pharmaceutical field to produce, and can add various pharmaceutically acceptable carrier when needs.Described carrier comprises the excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant etc. of pharmaceutical field routine.
Beneficial effect: the component of medicine of the present invention all adopts natural raw material of Chinese medicine, its preparation is easy, and medicine source is extensive, with low cost, it follows the prescriptions principle of the traditional Chinese medical science, and all medicines share, bring out the best in each other, preparation treating both the principal and secondary aspects of a disease of the present invention, have no side effect, can be used alone and good effect; And the difference for herbal raw material adopts different processing modes, drug effect is discharged to greatest extent, through clinical practice checking, it is reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects, have a extensive future.
Detailed description of the invention
Embodiment 1
For White staphylococcus sheet and the preparation technology thereof of cough-relieving, it is prepared by following raw material and obtains:
White staphylococcus powder 40g, dextrin 25g, 70% syrup (weight ratio) 35g, starch 5g, magnesium stearate 0.28g.
Get above-mentioned raw materials, conventionally pelletize, prepare 1000, tablet.
White staphylococcus sheet of the present invention, usage and dosage, one time 2,3 times on the one.
Embodiment 2
For the White staphylococcus sheet of cough-relieving, it is prepared by following raw material and obtains:
White staphylococcus powder 40g, Chinese medicine powder 20g, dextrin 25g, 70% syrup (weight ratio) 35g, starch 5g, magnesium stearate 0.28g.
Get above-mentioned raw materials, conventionally pelletize, prepare 1000, tablet.
Described Chinese medicine powder, prepared by the raw material of following weight and obtain:
Fructus Schisandrae Chinensis 40 parts, Herba Lysionoti Pauciflori 38 parts, Semen Juglandis 38 parts, Radix Platycodonis 38 parts, Semen Coicis 35 parts,
Radix Polygalae 35 parts, Olibanum 30 parts, Radix Isatidis 30 parts, 30 parts, Herba Ephedrae, 25 parts, Poria,
Herba Taraxaci 25 parts, Fructus Ligustri Lucidi 25 parts, Folium Ginkgo 20 parts, Rhizoma Dioscoreae 20 parts, Fructus Momordicae 20 parts,
Folium Perillae 15 parts, the Radix Stemonae 15 parts, Herba Schizonepetae 15 parts, Radix Ophiopogonis 10 parts, 10 parts, Radix Glycyrrhizae,
Ramulus Cinnamomi 10 parts, Fructus Crataegi 10 parts, Semen Plantaginis 10 parts, 10 parts, Folium Mori, Fructus Lycii 10 parts, Herba Lycopi 10 parts.
The preparation method of described Chinese medicine powder is as follows:
(1) above-mentioned raw materials is taken for subsequent use
(2) get Semen Juglandis, Radix Platycodonis, Radix Glycyrrhizae, Ramulus Cinnamomi, Fructus Crataegi pulverized 100 mesh sieves, mix homogeneously, prepare complex A;
(3) get Herba Lysionoti Pauciflori, Semen Coicis, Olibanum, Poria, Rhizoma Dioscoreae, the Radix Stemonae, Radix Ophiopogonis decoct with water, first time adds 5 times of weight water, decoct 1 hour, obtain filtrate and medicinal residues after filtration, medicinal residues are added 3 times of weight water and decoct half an hour, after filtration, obtain filtrate, merge twice filtrate, filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtain complex B;
(4) get surplus stock and add 2 times of weight 75%(volume ratios) ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverized and obtained complex C;
(5) namely Homogeneous phase mixing complex A, B, C obtain Chinese medicine powder.
White staphylococcus sheet of the present invention, usage and dosage, one time 2,3 times on the one.
Embodiment 3
One, toxicity test
This experiment adopts healthy SD rat, the drug dose gradient that respectively prepared by oral administration embodiment 1, embodiment 2 is 0.2g/kg and 1.0g/kg, successive administration 30 days, during observing rat administration and after drug withdrawal, within 1 week, growth of animal state, movable diet, hematology, blood biochemical analysis, organs and tissues structure and routine urinalysis etc. all have no significant effect, and show that clinical drug safety is reliable.
Two, strong aqua ammonia nebulization research antitussive effect
Get mice 80, male and female half and half, be divided into 4 groups at random, often group gastric infusion respectively, every day 1 time, continuous 3d.Matched group gives Jiangsu Shenhua White staphylococcus tablet prepared by Pharmaceutical (composition is White staphylococcus powder), after last administration 1h, mice accepts strong aqua ammonia spraying 10s, after spraying terminates, take out mice, observe time and the number of times of Respiratory frequency appearance, the cough latent period of record mice and 3min interior cough number of times, the results are shown in Table 1
Table 1 antitussive is tested
Group | Number of cases | Dosage | Cough number of times (3min) |
Model control group (normal saline) | 20 | 30.1±1.25 | |
Matched group | 20 | 0.1g/Kg | 21.3±1.13 |
Embodiment 1 group | 20 | 0.1g/Kg | 19.8±1.23 |
Embodiment 2 groups | 20 | 0.1g/Kg | 15.7±1.16 |
Embodiment 3
Clinical data
This group case selection accepts out-patient's totally 105 examples for medical treatment, and stochastic averagina is divided into three groups, matched group, embodiment 1 group, with embodiment 2 groups, often organize 35 people, three groups of not statistically significants (P>0.05) in sex, age, the course of disease and state of an illness distribution.
With reference to " Chinese medical disease Standardization of diagnosis and curative effect ": (1) cough with dyspnea is sound, or the expectoration of companion's itching throat; (2) exogenous cough, onset is anxious, can with exterior syndromes such as cold and heat; (3) endogenous cough, often because of diseases caused by exogenous pathogenic factor recurrent exerbation, the course of disease is longer, can cough and accompany and breathe heavily; (4) acute stage, have a blood test total white blood cells and neutrophilic granulocyte increased; (5) two lung auscultation audibles and respiratory murmur increase thick, or companion is dispersed in moist rale; (6) conducting lung X-ray examination takes the photograph sheet inspection, normal or increased bronchovascular shadows.
Therapeutic Method
Embodiment 1 group: give embodiment 1 prepare White staphylococcus sheet, one time 2,3 times on the one.
Embodiment 2 groups: give embodiment 2 prepare White staphylococcus sheet, one time 2,3 times on the one.
Matched group: white Portugal coccus sheet prepared by Jiangsu Shenhua Pharmaceutical, a 3-4 sheet, 3 to 4 times on the one;
The standard of curative effect evaluation
Determine that the standard of curative effect evaluation is as follows according to " disease of tcm Standardization of diagnosis and curative effect " (Nanjing: publishing house of Nanjing University, 1994): effective: the transference cures such as cough, heating, watery nasal discharge, headache, pharyngalgia, hemogram, chest film inspection are normal;
Effective: clinical symptom relief, hemogram, chest film inspection take a turn for the better;
Invalid: clinical symptoms is without obviously changing or increasing the weight of.
Therapeutic outcome: efficacy result sees the following form 2:
Table 2
Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
Matched group | 35 | 13 | 12 | 10 | 71.4% |
Embodiment 1 group | 35 | 15 | 11 | 9 | 74.3 |
Embodiment 2 groups | 35 | 21 | 13 | 1 | 97.1% |
Experimental group is matched group significant difference comparatively.
What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should think protection scope of the present invention.
Claims (5)
1., for a White staphylococcus sheet for cough-relieving, it comprises the preparation of following component and obtains:
White staphylococcus powder 40g, dextrin 25g, 70% syrup 35g, starch 5g, magnesium stearate 0.28g, conventionally prepare 1000, tablet.
2. White staphylococcus sheet according to claim 1, it is prepared by following component and obtains:
White staphylococcus powder 40g, Chinese medicine powder 20g, dextrin 25g, 70% syrup (weight ratio) 35g, starch 5g, magnesium stearate 0.28g, conventionally prepare 1000, tablet.
3. White staphylococcus sheet according to claim 2, is characterized in that, described Chinese medicine powder is prepared by the raw material of following weight and obtains:
Fructus Schisandrae Chinensis 40 parts, Herba Lysionoti Pauciflori 38 parts, Semen Juglandis 38 parts, Radix Platycodonis 38 parts, Semen Coicis 35 parts,
Radix Polygalae 35 parts, Olibanum 30 parts, Radix Isatidis 30 parts, 30 parts, Herba Ephedrae, 25 parts, Poria,
Herba Taraxaci 25 parts, Fructus Ligustri Lucidi 25 parts, Folium Ginkgo 20 parts, Rhizoma Dioscoreae 20 parts, Fructus Momordicae 20 parts,
Folium Perillae 15 parts, the Radix Stemonae 15 parts, Herba Schizonepetae 15 parts, Radix Ophiopogonis 10 parts, 10 parts, Radix Glycyrrhizae,
Ramulus Cinnamomi 10 parts, Fructus Crataegi 10 parts, Semen Plantaginis 10 parts, 10 parts, Folium Mori, Fructus Lycii 10 parts, Herba Lycopi 10 parts.
4. White staphylococcus sheet according to claim 3, is characterized in that, the preparation method of described Chinese medicine powder is as follows:
(1) above-mentioned raw materials is taken for subsequent use;
(2) get Semen Juglandis, Radix Platycodonis, Radix Glycyrrhizae, Ramulus Cinnamomi, Fructus Crataegi, pulverized 100 mesh sieves, mix homogeneously, prepare complex A;
(3) get Herba Lysionoti Pauciflori, Semen Coicis, Olibanum, Poria, Rhizoma Dioscoreae, the Radix Stemonae, Radix Ophiopogonis, mixing, decocts with water, and first time adds 5 times of weight water, decocts 1 hour, obtains filtrate and medicinal residues after filtration; Medicinal residues are added 3 times of weight water and decoct half an hour, obtain filtrate after filtration, merge twice filtrate, the filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverize and obtain complex B;
(4) get surplus stock, mixing, add the ethanol of 2 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtains complex C;
(5) Homogeneous phase mixing complex A, B, C, obtain Chinese medicine powder.
5. the purposes of White staphylococcus sheet described in claim 1-3.
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CN108159009A (en) * | 2018-02-28 | 2018-06-15 | 仁和堂药业有限公司 | A kind of preparation method of high stability White staphylococcus tablet |
EP3766509A4 (en) * | 2018-03-16 | 2021-04-21 | Helixmith Co., Ltd | Crude drug composition for preventing or treating respiratory diseases |
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CN108159009A (en) * | 2018-02-28 | 2018-06-15 | 仁和堂药业有限公司 | A kind of preparation method of high stability White staphylococcus tablet |
EP3766509A4 (en) * | 2018-03-16 | 2021-04-21 | Helixmith Co., Ltd | Crude drug composition for preventing or treating respiratory diseases |
JP2021516690A (en) * | 2018-03-16 | 2021-07-08 | ヘリックスミス カンパニー, リミテッド | Herbal composition for the prevention or treatment of respiratory diseases |
JP2022163181A (en) * | 2018-03-16 | 2022-10-25 | ヘリックスミス カンパニー, リミテッド | Crude drug composition for preventing or treating respiratory diseases |
US11541097B2 (en) | 2018-03-16 | 2023-01-03 | Helixmith Co., Ltd. | Crude drug composition for preventing or treating respiratory diseases |
JP7255901B2 (en) | 2018-03-16 | 2023-04-11 | ヘリックスミス カンパニー, リミテッド | Herbal medicine composition for prevention or treatment of respiratory diseases |
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