CN105407870A - Organogel composition and organogel mask pack produced by using same - Google Patents

Organogel composition and organogel mask pack produced by using same Download PDF

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Publication number
CN105407870A
CN105407870A CN201380078473.7A CN201380078473A CN105407870A CN 105407870 A CN105407870 A CN 105407870A CN 201380078473 A CN201380078473 A CN 201380078473A CN 105407870 A CN105407870 A CN 105407870A
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organogel
oil
weight
composition
organogel composition
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Inventor
刘眩旿
金钟喆
金成长
梁珍雅
金旼奭
孙泰垣
崔升银
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Genic Co Ltd
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Genic Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212Face masks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/042Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/737Galactomannans, e.g. guar; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8111Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

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  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to an organogel mask pack composition and to an organogel mask pack produced by using same. More specifically, the present invention relates to an organogel composition comprising an oil, an oil gelling agent, water, a polyhydric alcohol, a gelling polymer and a skin-active component, and to an organogel mask pack produced by using same. In the organogel composition according to the present invention, the organogel structure has a lamellar structure similar to skin such that skin affinity is improved, and, as a result, the skin-active component can be transmitted both easily and rapidly. Also, the organogel composition according to the present invention has a relatively high content of oil such that various oil-soluble skin-active components can easily be transmitted and skin moisture maintained for a long time, and transepidermal water loss can be reduced.

Description

The organogel facial film of organogel composition and preparation thereof
Technical field
The present invention relates to the organogel facial film of organogel composition and preparation thereof, relate more specifically to a kind of organogel composition, the active component be wherein suspended in this organogel has good transepidermal absorption, and the organogel facial film using this organogel composition to prepare.
Background technology
Term " organogel " is initial for describing concept (" colloid and the polymer science (Colloid & PolymerScience) " of Rui Si (Luisi) etc. of concrete oil-in-water Microemulsions lyogel, 1990,268 volumes, 356-374 page).
Now, this term comprises the system of gelling, mainly containing system (" pharmaceutical science periodical (JournalofPharmaceuticalScience) " of William's nurse (Williman) etc. by the hydrogenation of two phases of not dissolving each other of the lecithin stabilisation being rich in phosphatidylcholine, 1992,81 volumes, " gel periodical (ColloidJournal) " of 871-874 page and Si Qieqipunuofu (Schchipunov) etc., 1995,57 volumes, 556-560 page).Organogel has the thin slice phase similar to skin texture, it is characterized in that, the acquisition of gel does not need gellant.
Organogel, particularly lecithin oranogel, the affinity had skin because it has the flake structure similar to skin, also can keep moistening effect simultaneously within a very long time on skin.Therefore, organogel uses in various cosmetic composition.
No. 0843155th, Korean Patent discloses the cosmetic composition contained by the ascorbic skin-whitening of the Lecithin Gel stabilisation with lecithin-organogel structure.
In addition, No. 0824212nd, Korean Patent discloses containing the skin care cosmetic composition of the Placenta Hominis of stabilisation by collection in organogel.
Estimate that the organogel composition improved is useful for facial film, in this gel combination, be suspended in active component in organogel can easily and send rapidly.
Summary of the invention
Technical problem
One aspect of the present invention provides a kind of organogel composition, and its active component can easily transepidermal absorption.
Another aspect of the present invention provides the organogel facial film adopting above-mentioned organogel composition to prepare.
Technical scheme
According to an aspect of the present invention, organogel composition comprises oil, oily gellant, polyhydric alcohol, water, gel polymer and active component.
According to another aspect of the present invention, organogel facial film uses above-mentioned organogel composition to prepare.
Beneficial effect
The organogel structure that organogel composition according to the present invention has has the affinity of improvement due to its flake structure (similar to the structure of skin) with skin, and therefore active component can easily and send rapidly.In addition, organogel composition of the present invention has relatively high oil content, and therefore the active component of various oil can easily be sent, and moisture of skin can keep a very long time, thus decreases the water loss of skin.
Preferred forms
According to an aspect of the present invention, provide a kind of organogel composition, in the composition, the active component be suspended in organogel can easily by transepidermal absorption.
More specifically, according to the present invention, organogel composition comprises oil, oily gellant, polyhydric alcohol, water, gel polymer and active component.
Oil used in the present invention can be at least one be selected from lower group: isopropyl myristate, ethyl laurate, ethyl myristate, isopropyl palmitate, Pentamethylene., cyclooctane, trans-decahydronaphthalene, pentane, normal hexane, hexadecane, tripropyl amine (TPA), 1, 7-octadiene, butyl laurate, cyclododecane, dibutyl ethers, isobutyltrimethylmethane., normal octane, tri-n-butylamine, triisobutyl amine, polyol ester, triglyceride, diglyceride, monoglyceride, diglyceride and fatty acid ester, in addition, can be selected from least one of lower group or multiple mixture: ester oil, such as caprylic/capric triglyceride, butanediol dicaprylate/dicaprate, three isooctyl acid glyceride (triethylhexanoin), thylhexoic acid cetyl ester, isopropyl myristate, octyldodecanol, hydrocarbon ils, such as liquid paraffin, vaseline, hydrogenated polydecene, zamene, wax, such as microwax, Cera Flava, lanolin wax, natural oil, such as Jojoba oil (jojobaoil), American Avocado Tree oil, almond oil, olive oil, Oleum sesami, wheat germ oil, safflower oil, Camellia oil, Oleum Ricini, Oleum Vitis viniferae, Oleum Camelliae (Camelliasinensisseedoil), macadimia nut oil, Oleum Cocois, Rosehips oil, fixed oil, argan oil (arganoil), Oleum Hippophae (Hippophaerhamnoidesoil), thorn A Gan set core oil (Arganiaspinosakerneloil), Oleum lavandula angustifolia, silicone oil, such as cyclomethicone, phenyl trimethicone (phenyltrimethicone), cyclopentasiloxane, dimethicone, but be not limited to aforesaid kind.Preferably use ester oil, such as caprylic/capric triglyceride, butanediol dicaprylate/dicaprate, glycerol three (thylhexoic acid) ester, thylhexoic acid cetyl ester, isopropyl myristate, octyldodecanol.
Gross weight for the organogel composition of facial film is benchmark meter, and the content of described oil can be 5-45 % by weight, is more preferably 10-30 % by weight.If the gross weight for the organogel composition of facial film is benchmark meter, the content of described oil is lower than 10 % by weight, and the content of oil is too low can not form required organogel composition, and may reduce the transepidermal absorption of required active component.If the content of fruit oil is higher than 45 % by weight, so oil is from aqueous phase separation, is difficult to form final facial film.
Oil gellant can be selected from least one of lower group: lecithin, pluronic lecithin (Pluroniclecithin), fatty acid sorbitol ester, gelatin, 1B, limonene and polyethylene, and can use their mixture.
Gross weight for the organogel composition of facial film is benchmark meter, and the content of described oily gellant can be 0.1-10 % by weight, is more preferably 3-7 % by weight.If the gross weight for the organogel composition of facial film is benchmark meter, lower than 0.1 % by weight, can there is the problem of oil from aqueous phase separation in the content of described oily gellant.If the content of oily gellant is higher than 10 % by weight, the problem causing organogel low elasticity can be there is.
Polyhydric alcohol used in the present invention together with water as solvent.Described polyhydric alcohol can be selected from least one of lower group: glycerol, ethylene glycol, propylene glycol, dipropylene glycol and butanediol or their mixture.
In the gross weight of organogel composition for benchmark, the content of described polyhydric alcohol can be 0.5-35 % by weight, is more preferably 5-15 % by weight.If the content of polyhydric alcohol is lower than 0.5 % by weight, then gel polymer is difficult to be disperseed.If the content of polyhydric alcohol is higher than 35 % by weight, so the content of water is just relatively low, thus the intensity of gel can reduce in time, and the adhesive characteristics on skin can excessively increase.
In the present invention, the water meter in organogel shows surplus.That is, the amount of the water of interpolation obtains the composition that total amount is 100 % by weight.Sectional type adds water, and add water by this way, other component in addition to water can easily be dissolved.
Described gel polymer is selected from least one of lower group or multiple mixture: natural sugar, such as galactomannan gum, glucomannan, guar gum, locust bean gum, pluronic (Pluronic), agar, algin, carrageenin, xanthan gum, extracellular polysaccharide, gelatin, methylcellulose, cellulose, carboxymethyl cellulose and hydroxyethyl-cellulose; With hydrophilic gellant, such as polyacrylate or its salt, polymethacrylates, CVP Carbopol ETD2050, polyvinyl alcohol, polyacrylamide, poly(ethylene oxide), polymine and polyvinyl pyrrolidone.
In the gross weight of organogel composition of the present invention for benchmark, the content of described gel polymer can be 0.1-10 % by weight, is more preferably 0.5-5 % by weight.In the gross weight of organogel composition for benchmark, if the content of water-soluble polymer is lower than 0.1 % by weight, can gel be formed, but this gel may have high strength and low elasticity, and therefore reduce the adhesiveness with skin.If described polymer content is higher than 20 % by weight, due to gel may loose, rupture and there is low elasticity and be difficult to prepare gel.
In the present invention, at least two kinds of gel polymers can be added to obtain crosslinked substrate.When described substrate is used as beauty treatment skin film, preferably retain the shape of organogel.
Most preferably, at least one can be selected from the polymer of the branching of lower group: galactomannan gum, glucomannan, guar gum, locust bean gum and pluronic, be selected from the electrolysis polymerization thing of lower group with at least one: agar, algin, carrageenin, xanthan gum, extracellular polysaccharide and gelatin mix.
Described electrolysis gel polymer makes compositions of the present invention under room temperature (about 20 DEG C), preferably at 0-30 DEG C, keeps gel state.The gel polymer of described branching makes organogel of the present invention in higher temperature (be 10-50 DEG C, be preferably the about 30-40 DEG C close to human body temperature) current downflow, thus described organogel can be effectively applied to skin.
In the gross weight of compositions for substrate, the gel polymer of branching and the content of electrolysis gel polymer can be respectively 0.05-10 % by weight and 0.05-5 % by weight.If their content deviate from these scopes, gel may not be formed, or gel may not flow at a higher temperature.
In the present compositions, if needed, described gel polymer can mix with the cross-linking agent that at least one is selected from acrylic polymer, styrenic polymer and their mixture.Such as, described cross-linking agent can be selected from lower group one or both or more plant: sodium acrylate/acrylic acid C10-30 alkyi acrylate cross copolymer (crosspolymer) or potassium acrylate/acrylic acid C10-30 alkyi acrylate cross copolymer, acrylate/EHA/HEMA/ styrol copolymer, butylene/ethylene/styrene copolymer, ammonium acrylate/methyl styrene/styrol copolymer, styrene/VP copolymer and phenylethylene ethylene/propenoic acid ester copolymer.
When adding cross-linking agent, it is for improving the physical property of organogel of the present invention, promotes that thin film is formed simultaneously, thus improves with the adhesiveness of skin and effectively keep moisture.In addition, cross-linking agent can be used for giving soft sensation.In the gross weight of described organogel composition for benchmark, described cross-linking agent can add 0.01-5 % by weight.
In addition, it can the active component that use can be selected from least one of lower group in the organogel composition being used as facial film: retinol, retinyl palmitate, retinyl acetate, tretinoin, coenzyme Q10, elastin laminin, collagen, hyaluronic acid, ceramide, collagen, caffeine, chitosan, ascorbic acid, ascorbic acid glucoside, α-bisabolol, tocopherol, tocopheryl acetate, arbutin, nicotiamide, adenosine, vitamin A acetate (retinolacetate, ), vitamin A, D and E and other natural extract, be preferably their mixture.
When preparing facial film with the organogel composition for facial film according to the present invention, especially, the transepidermal absorption of oily component (such as tocopheryl acetate, vitamin A acetate, vitamin A, D and E, ceramide, coenzyme Q10 and α-bisabolol) can greatly be improved.
Described natural extract or multiple extract can be the extracts that at least one is selected from lower group: Aloe, green tea, Radix Ginseng, Radix Ginseng Rubra, pyroligneous acid, Folium Pini, Folium Ginkgo, propolis, Folium Mori, silkworm, Limax mucus, KaKadu Plum (kakaduplum), Camu Camu (camucamu), Acai Petiolus Trachycarpi (acaipalm), squalane, caviar, Broccoli, blue berry, Radix Hamamelidis Mollis, Malpighia coccigera, chlorella, Carcinia mangostana L., Fructus psidii guajavae immaturus, Japanese cherry (Japanesecorneliancherry), Radix Dauci Sativae, coffee bean, Radix Hamamelidis Mollis, spirulina, salmon roe, Fructus Linderae Glaucae (Linderaglauca), Macrocystis pyrifera (L.) Ag., Thallus Laminariae (Thallus Eckloniae), Herba Portulacae, ulva, agar, Mulberry Roots, Fructus Rubi, wild acinus, Sargassum fusiforme (Harv.) Setch (hijiki), gulfweed, Leontopodium leontopodioides (Willd.) Beauv., Flos Chrysanthemi, lavandula angustifolia, Herba Menthae, Eucalyptus, Herba melissae axillaris, Adeps Bovis seu Bubali, Camellia sinensis, Radix Scutellariae (Scutellaria), Herba Houttuyniae (Houttuyniacordata), Fructus Hippophae and Fructus Citri.
In the gross weight of compositions for benchmark, the content of described active component can be 0.05-10 % by weight, is more preferably 2-5 % by weight.In the gross weight of compositions for benchmark, if the content of active component is lower than 10 % by weight, so the effect of beauty treatment skin is low.If the content of active component is higher than 20 % by weight, skin irritation may be there is.
In addition, according to application, if needed, other additive can be added, such as pH adjusting agent, as citric acid, potassium hydroxide and arginine salt; Antiseptic, as parabens, is specially methyl parahydroxybenzoate, propyl p-hydroxybenzoate and phenoxyethanol; Metal ion sealer, as 2NaEDTA; And wetting agent, as betanin, Sorbitol, 1,2-hexanediol and erythritol.
In the gross weight of organogel composition of the present invention for benchmark, the content of described additive can be 0.01-10 % by weight, is more preferably 0.05-5 % by weight.
Organogel composition according to the present invention has the affinity of improvement due to its flake structure (similar to skin) with skin, and therefore active component can easily and rapidly from organogel to dermal delivery.In addition, organogel according to the present invention has relatively high oil content, and therefore the active component of various oil can easily be sent, and moisture of skin can keep a very long time, thus decreases the water loss of skin.
The facial film of organogel composition of the present invention is used to prepare by following methods:
First, if needed, additive is blended in water, and this mixture is heated to dissolve these components at about 70-80 DEG C.In this mixture, add another kind of mixture, in described another kind of mixture, add gel polymer, beautifying skin component and polyhydric alcohol and be dissolved in residue water, the new blend obtained is stirred to obtain homogeneous solution.If needed, also cross-linking agent can be added.If temperature is lower than 70 DEG C, component may not be dissolved completely in water.If temperature is higher than 80 DEG C, some additives or natural constituents may have poor stability.
When preparing organogel of the present invention, the water added reaches certain amount with the compositions obtaining total amount 100 % by weight.Sectional type adds water, adds water by this way and often plants component and can easily dissolve.
Dropwise add at about 70-80 DEG C in the solution of mixing, to prepare organogel solution respectively to the mixture wherein adding oil and oily gellant.If needed, additive such as antiseptic also can be added.If mixing temperature is lower than 70 DEG C, aqueous phase and oil phase can not easily mix, and may be difficult to prepare organogel.If temperature is higher than 80 DEG C, the material in aqueous phase and oil phase may have poor stability.
The organogel solution obtained coating is cooled to room temperature on the support subsequently, is shaped as the form of needs subsequently to prepare facial film.
Described holder can be nylon, artificial silk, adhesive-bonded fabric etc., even more preferably mesh fabric.
Organogel facial film is shaped as there is the required part meeting human body, the such as form of face, lower part of eye, buccal, chin and cervical region, to obtain final facial film.In addition, the two sides of available thin film protection organogel facial film.
Thickness for applying organogel composition on the support can be 0.01-50mm.If thickness is less than 0.01mm, the thickness gel reduced due to it when adhering on skin may disconnect, and in gel, the amount of active component is not enough to them to be delivered to skin very little.If thickness is greater than 50mm, gel is too thick, reduces with the adhesiveness of skin.
Hereinafter, the present invention is described in detail with reference to specific embodiment.Help to understand mode of the present invention by way of example and comprise following examples, but they are not limited to scope of the present invention.
Invention embodiment
Embodiment
1. the preparation of organogel facial film
Embodiment 1 and 2
First, in the first purified water, mix EDTA2Na, betanin and methyl parahydroxybenzoate and be heated to about 75-80 DEG C to dissolve these components.Be added in the solution that is mixed with nicotiamide, butanediol, glycerol, carrageenin and locust bean gum in the second purified water wherein and mix.For embodiment 1 and 2, the content of often kind of component is displayed in Table 1.
Respectively, at 75-80 DEG C, while the described solution of stirring, in described solution, the mixture of caprylic/capric triglyceride (MCT), lecithin and propyl p-hydroxybenzoate is dropwise added to prepare organogel solution.
Described organogel solution is coated in the two sides of artificial mesh fabric, and is shaped as required form to prepare organogel facial film.
Table 1
Embodiment 3 and 4
First, in the first purified water, mix EDTA2Na, Sorbitol, methyl parahydroxybenzoate and sodium acrylate/acrylic acid C10-30 alkyi acrylate cross copolymer, and be heated to about 75-80 DEG C to dissolve these components.In said mixture, add solution and mix, this solution is included in the tocopheryl acetate, glycerol, carrageenin and the locust bean gum that mix in the second purified water.For embodiment 3 and 4, the content of often kind of component is displayed in Table 2.
Respectively, the mixture of the mixture or three isooctyl acid glyceride and lecithin that dropwise add butanediol dicaprylate/dicaprate and lecithin in described solution while stirring described solution at 75-80 DEG C is to prepare organogel solution.
Described organogel solution is coated in the two sides of artificial mesh fabric, and is shaped as required form to prepare organogel facial film.
Table 2
Embodiment 5 and 6
First, in the first purified water, mix EDTA2Na, Sorbitol, butylene/ethylene/styrene copolymer and methyl parahydroxybenzoate and be heated to about 75-80 DEG C to dissolve these components.In said mixture, add solution and mix, this solution is included in the α-bisabolol, glycerol, carrageenin and the glucomannan that mix in the second purified water.For embodiment 5 and 6, the content of often kind of component is displayed in Table 3.
Respectively, at 75-80 DEG C, while the described solution of stirring, in described solution, the mixture of palmityl ethylhexoate and lecithin or the mixture of isopropyl myristate and pluronic lecithin is dropwise added to prepare organogel solution.
Described organogel solution is coated in the two sides of artificial mesh fabric, and is shaped as required form to prepare organogel facial film.
Table 3
Embodiment 7 and 8
First, in the first purified water, mix EDTA2Na, Sorbitol, butylene/ethylene/styrene copolymer and methyl parahydroxybenzoate and be heated to about 75-80 DEG C to dissolve these components.In said mixture, be added in solution and mix, this solution comprises α-bisabolol, glycerol, glucomannan and the gellan or carrageenin that mix in the second purified water.For embodiment 7 and 8, the content of often kind of component is displayed in Table 4.
Respectively, at 75-80 DEG C, while the described solution of stirring, in described solution, the mixture of palmityl ethylhexoate and lecithin or the mixture of isopropyl myristate and pluronic lecithin is dropwise added to prepare organogel solution.
Described organogel solution is coated in the two sides of artificial mesh fabric, and is shaped as required form to prepare organogel facial film.
Table 4
Comparative example 1 and 2
First, in the first purified water, mix EDTA2Na, betanin and methyl parahydroxybenzoate and be heated to about 75-80 DEG C to dissolve these components.In said mixture, add solution and mix, this solution is included in the tocopheryl acetate, glycerol, locust bean gum and the carrageenin that mix in the second purified water.For comparative example 1 and 2, the content of often kind of component is displayed in Table 5.
Respectively, at 75-80 DEG C, while the described solution of stirring, in described solution, the mixture of MCT, lecithin and propyl p-hydroxybenzoate is dropwise added to prepare organogel solution.
Described organogel solution is coated in the two sides of artificial mesh fabric, and is shaped as required form to prepare organogel facial film.
Table 5
Numbering Raw material title Comparative example 1 Comparative example 2
1 First purified water 80.02 10.62
2 EDTA 2Na 0.01 0.01
3 Betanin 0.5 0.5
4 Methyl parahydroxybenzoate 0.2 0.2
5 Second purified water 10 10
6 Tocopheryl acetate 2 2
7 Glycerol 2.5 15
8 Locust bean gum 1.2 1.2
9 Carrageenin 0.45 0.45
10 MCT (caprylic/capric triglyceride) 3 50
11 Lecithin 0.1 10
12 Propyl p-hydroxybenzoate 0.02 0.02
The evaluation of the physical property of organogel facial film
Measure the physical property of the organogel facial film prepared in embodiment and comparative example, and show result in the following table.
(1) evaluation of moistening effect
The organogel of preparation is cut into the circle that diameter is 10mm, measures its initial weight.Then, the Medial upper arm of 20 healthy womens is sticked to.Subsequently, after stripping, measure the weight of the organogel of preparation.Calculate the difference between two weight.In order to prevent moisture from evaporating, cover having safely on this organogel with the vinyl of organogel same size.
In order to evaluate the water quantities of reservation, with moisture of skin tester (Corneometer) CM825 (German C & K company (Courage+KhazakaElectronicGmbH, Germany)) moistening effect on the skin area being stained with organogel is measured, water capacity in described moisture of skin tester energy non-invasive measurement body.In addition, moisture loss amount (g/m is measured with skin water loss tester (Tewarmeter) TM210 (German C & K company) 2h), described skin water loss tester can measure transepidermal moisture loss (TEWL).
Measure and carry out with it in every 20 women, calculate the meansigma methods obtained from these women.The results are shown in Table 6.
(2) skin irritant evaluation
Organogel is cut into the circle that diameter is 10mm, and adhered to the Medial upper arm of 20 healthy womens.Subsequently, after 24 hours, peeled off, according to following standard with the naked eye evaluating skin situation.The results are shown in Table 6.
do not stimulate
Zero: minimal irritation
: erythema
Δ: erythema and edema
X: erythema, edema and blister
(3) evaluation of stability (variable color, gel strength, be separated)
At 25 DEG C, organogel is placed in surrounding air, during this period according to following standard 60 minutes, 5 hours, 10 hours and 24 little physical changes of with the naked eye measuring this organogel constantly.The results are shown in Table 6.
the state kept
Zero: variable color, gel strength (dying down), being separated is less than 10% of overall area
: variable color, gel strength (dying down), being separated is less than 30% of overall area
Δ: variable color, gel strength (dying down), being separated is less than 50% of overall area
X: variable color, gel strength (dying down), being separated is less than 80% of overall area
Table 6
As shown in table 6, demonstrate, according to embodiments of the invention 1-4, there is good moistening effect, low skin irritation and high stability.On the contrary, the moistening effect of comparative example 1 is inadequate, and skin irritation is higher and stability is lower, because comparative example 2 can not prepare gel, therefore can not measure the physical property of comparative example 2.
The evaluation of transepidermal absorption
Carry out skin in vivo with the skin of hairless mouse and transmit test.Each 48 microlitres of sample of embodiment 3 and 4 and comparative example 1 are administered to the skin surface of the 15.0mm diameter of mouse.With transepidermal absorber (Hanson microette tM) amount of the tocopheryl acetate transmitted after 24 hours is measured by liquid chromatograph.The results are shown in Table 7.As shown in table 7, prove that the transepidermal absorption according to embodiments of the invention 3 and 4 is better than the transepidermal absorption of comparative example 1.
Table 7
Sample Embodiment 3 Embodiment 4 Comparative example 1
Transmit 15.3% 16.1% 7.2%
(5) evaluation of wrinkle improvement
The organogel of preparation in embodiment 3 and 4 and comparative example 1 is sticked to equably the around eyes of the 20 years old women in 40-60 position every day for 2 times with the ring form of 20mm.This test is carried out 3 months altogether, measures crows-feet simultaneously.The organogel of preparation in embodiment 3 or 4 is applied in left eye, the compositions of preparation in comparative example 1 is applied in right eye.
After 3 months, with the naked eye evaluate the improvement (by 4 grades of mensuration: do not improve relative to reference examples, slightly improve, appropriateness improves and significantly improve) of wrinkle.The results are shown in Table 8.
Table 8
Do not improve Slight improvement Appropriateness is improved Remarkable improvement
Embodiment 3 1 2 3 4
Embodiment 4 0 2 4 4
Comparative example 1 3 3 3 1
In addition, before and after by organogel repetitive administration to around eyes, the degree of depth (μm) of wrinkle is measured by imaging analysis method.Result (wrinkle depth reduction) is in table 9.
Table 9
Embodiment 3 Embodiment 4 Comparative example 1
Before using 325±41 308±39 295±35
After using 90 days 179±41 255±32 276±37
The reduction of wrinkle depth 14.10% 17.20% 6.40%
As shown in Table 8 and 9, prove that organogel prepared in accordance with the present invention has good transepidermal absorption and effect improving wrinkles.

Claims (16)

1. an organogel composition, described compositions comprises oil, oily gellant, water, polyhydric alcohol, gel polymer and active component.
2. organogel composition as claimed in claim 1, it is characterized in that, described oil is selected from least one in lower group: isopropyl myristate, ethyl laurate, ethyl myristate, isopropyl palmitate, Pentamethylene., cyclooctane, trans-decahydronaphthalene, pentane, normal hexane, hexadecane, tripropyl amine (TPA), 1,7-octadiene, butyl laurate, cyclododecane, dibutyl ethers, isobutyltrimethylmethane., normal octane, tri-n-butylamine, triisobutyl amine, polyol ester, triglyceride, diglyceride, monoglyceride, diglyceride; Caprylic/capric triglyceride, butanediol dicaprylate/dicaprate, three isooctyl acid glyceride, thylhexoic acid cetyl ester, isopropyl myristate, octyldodecanol; Liquid paraffin, vaseline, hydrogenated polydecene, zamene; Microwax, Cera Flava, lanolin wax; Jojoba oil, American Avocado Tree oil, almond oil, olive oil, Oleum sesami, wheat germ oil, safflower oil, Camellia oil, Oleum Ricini, Oleum Vitis viniferae, Oleum Camelliae, macadimia nut oil, Oleum Cocois, Rosehips oil, fixed oil, argan oil, Oleum Hippophae, thorn A Gan set core oil, Oleum lavandula angustifolia; And silicone oil, such as cyclomethicone, phenyl trimethicone, cyclopentasiloxane and dimethyl siloxane.
3. organogel composition as claimed in claim 1, it is characterized in that, in the gross weight of described organogel composition for benchmark, the content of described oil is 5 % by weight-45 % by weight.
4. organogel composition as claimed in claim 1, is characterized in that, described oily gellant is selected from least one of lower group: lecithin, pluronic lecithin, fatty acid sorbitol ester, gelatin, 1B, limonene and polyethylene.
5. organogel composition as claimed in claim 1, it is characterized in that, in the gross weight of described organogel composition for benchmark, the content of described oily gellant is 0.1 % by weight-10 % by weight.
6. organogel composition as claimed in claim 1, is characterized in that, described polyhydric alcohol is selected from least one of lower group: glycerol, ethylene glycol, propylene glycol, dipropylene glycol and butanediol.
7. organogel composition as claimed in claim 1, it is characterized in that, in the gross weight of described organogel composition for benchmark, the content of described polyhydric alcohol is 0.5 % by weight-35 % by weight.
8. organogel composition as claimed in claim 1, it is characterized in that, described gel polymer is selected from least one of lower group: galactomannan gum, glucomannan, guar gum, locust bean gum, pluronic, agar, algin, carrageenin, xanthan gum, extracellular polysaccharide, gelatin, methylcellulose, cellulose, carboxymethyl cellulose, hydroxyethyl-cellulose, polyacrylate or its salt, polymethacrylates, CVP Carbopol ETD2050, polyvinyl alcohol, polyacrylamide, poly(ethylene oxide), polymine and polyvinyl pyrrolidone.
9. organogel composition as claimed in claim 1, it is characterized in that, in the gross weight of described organogel composition for benchmark, the content of described gel polymer is 0.1 % by weight-10 % by weight.
10. organogel composition as claimed in claim 1, it is characterized in that, described active component is selected from least one of lower group: retinol, retinyl palmitate, retinyl acetate, tretinoin, coenzyme Q10, elastin laminin, collagen, hyaluronic acid, ceramide, collagen, caffeine, chitosan, ascorbic acid, ascorbic acid glucoside, α-bisabolol, tocopherol, tocopheryl acetate, arbutin, nicotiamide, adenosine, vitamin A acetate, vitamin A, D and E and natural extract.
11. organogel compositions as claimed in claim 10, it is characterized in that, one or more natural extracts described extract the extract from least one being selected from lower group: Aloe, green tea, Radix Ginseng, Radix Ginseng Rubra, pyroligneous acid, Folium Pini, Folium Ginkgo, propolis, Folium Mori, silkworm, Limax mucus, KaKadu Plum, Camu Camu, Acai Petiolus Trachycarpi, squalane, caviar, Broccoli, blue berry, Radix Hamamelidis Mollis, Malpighia coccigera, chlorella, Carcinia mangostana L., Fructus psidii guajavae immaturus, Japanese cherry, Radix Dauci Sativae, coffee bean, Radix Hamamelidis Mollis, spirulina, salmon roe, Fructus Linderae Glaucae, Macrocystis pyrifera (L.) Ag., Thallus Laminariae (Thallus Eckloniae), Herba Portulacae, ulva, agar, Mulberry Roots, Fructus Rubi, wild acinus, Sargassum fusiforme (Harv.) Setch, gulfweed, Leontopodium leontopodioides (Willd.) Beauv., Flos Chrysanthemi, lavandula angustifolia, Herba Menthae, Eucalyptus, Herba melissae axillaris, Adeps Bovis seu Bubali, Camellia sinensis, Radix Scutellariae, Herba Houttuyniae, Fructus Hippophae and Fructus Citri.
12. organogel compositions as claimed in claim 1, is characterized in that, in the gross weight of described organogel composition for benchmark, the content of described active component is 0.05 % by weight-10 % by weight.
13. organogel compositions as claimed in claim 1, it is characterized in that, described organogel composition also can comprise the cross-linking agent that at least one is selected from lower group: sodium acrylate/acrylic acid C10-30 alkyi acrylate cross copolymer or potassium acrylate/acrylic acid C10-30 alkyi acrylate cross copolymer, acrylate/EHA/HEMA/ styrol copolymer, butylene/ethylene/styrene copolymer, ammonium acrylate/methyl styrene/styrol copolymer, styrene/VP copolymer and phenylethylene ethylene/propenoic acid ester copolymer.
14. organogel compositions as claimed in claim 13, is characterized in that, in the gross weight of described organogel composition for benchmark, the content of described cross-linking agent is 0.01 % by weight-5 % by weight.
15. 1 kinds of organogel facial films, it comprises: the organogel layer that the organogel composition according to any one of claim 1-14 is formed; And holder.
16. organogel facial films as claimed in claim 15, is characterized in that, described organogel layer coating thickness is on the support 0.01mm-50mm.
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