CN105395718A - Externally applied traditional Chinese medicine composition used for treating viral keratitis - Google Patents

Externally applied traditional Chinese medicine composition used for treating viral keratitis Download PDF

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CN105395718A
CN105395718A CN201510959912.6A CN201510959912A CN105395718A CN 105395718 A CN105395718 A CN 105395718A CN 201510959912 A CN201510959912 A CN 201510959912A CN 105395718 A CN105395718 A CN 105395718A
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parts
herba
medicine composition
chinese medicine
radix
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秦蕾蕾
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Qingdao Municipal Hospital
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Qingdao Municipal Hospital
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Abstract

The invention discloses an externally applied traditional Chinese medicine composition used for treating viral keratitis, and belongs to the field of drugs used for treating keratitis. The externally applied traditional Chinese medicine composition is prepared from, by weight, 20 to 30 parts of elephantopus scaber, 10 to 20 parts of thesium chinense, 10 to 20 parts of chamomile, 5 to 10 parts of herba asari, 1 to 5 parts of halloysitum rubrum, 10 to 20 parts of radix polygalae, 8 to 15 parts of rhizoma paridis chinensis, 10 to 20 parts of oldenlandia diffusa, 10 to 20 parts of herba scutellariae barbatae, 8 to 15 parts of rhizoma polygoni cuspidati, 5 to 10 parts of corydalis bungeana, 10 to 20 parts of spica prunellae, 10 to 20 parts of emilia sonchifolia, 8 to 15 parts of radix prismatomeris connatae, 10 to 20 parts of caulis Lonicerae, 8 to 15 parts of radix tinosporae, 5 to 10 parts of pseudo-ginseng, 8 to 15 parts of mulberry leaf, 5 to 10 parts of fructus chaenomelis, and 5 to 10 parts of lignum sappan. The externally applied traditional Chinese medicine composition is applied to human body main and collateral channels, is capable of reaching the deep of focus of infection, clearing heat and cooling blood, detoxifying and inducing dieresis, removing edema and dispersing blood stasis, clearing liver fire, tranquilizing the mind and promoting the intelligence, removing nebula, improving immunity, and treating both manifestation and root cause of diseases; and no recurrence is caused.

Description

A kind of external medicine composition for the treatment of viral keratitis
Technical field
The invention belongs to the technical field of the medicine for the treatment of keratitis, refer to a kind of external medicine composition for the treatment of viral keratitis especially.
Background technology
Viral keratitis is the inflammation caused by viral pathogenesis original sense dye cornea, has the trend obviously rising and aggravate in recent years.Due to its recurrent exerbation, severe cases increases, serious threat visual function, therefore strengthens the research to primary disease, has become the problem that ophthalmology is urgently to be resolved hurrily.Primary disease complicated clinical manifestation, except typical branch, map and plate-like cornea focus form, also have some atypical Clinical changes, this brings very large difficulty to Diagnosis and Treat.Various not only have unique Clinical symptoms, and its pathogeny and Therapeutic Principle are also not quite similar, dye various between can mutually transform, determine that the factor of this conversion is very complicated, outside the Pass having with the immunologic function (mainly cellular immunization) of Virus Type and strain and host, also relevant with Therapeutic Method (particularly the application of Corticosterone).
At present, the treatment of viral keratitis mainly contains two kinds of methods, and one is doctor trained in Western medicine antiviral therapy method, such as: the medicine for external use such as ganciclovir, acycloguanosine (ACV) and injection medicine for external use; Another kind is the prescription of tcm clinical practice through commonly using, and mainly contains: the oral medicine such as Notopterygii Decoction for Eliminating Wind, Sang Ju Yin YINQIAO soup, detoxification soup.But still there is skin bad adaptability in these therapies (traditional Chinese medical science and doctor trained in Western medicine), effective ingredient absorbs slowly, the course for the treatment of is long, the deficiency of easily recurrence, makes its therapeutic effect very undesirable.
Summary of the invention
The invention provides a kind of external medicine composition for the treatment of viral keratitis, solve in prior art the medicine for the treatment of keratitis and there is the problem that the course for the treatment of is long, effective ingredient absorbs slowly and uncertain therapeutic efficacy is cut.
A kind of external medicine composition for the treatment of viral keratitis of the present invention, it is mainly realized by the following technical programs: the raw material comprising following weight portion is made: Herba Elephantopi scaberis 20-30 part, Herba Thesii Longifolii 10-20 part, chamomile 10-20 part, Herba Asari 5-10 part, Halloysitum Rubrum 1-5 part, Radix Polygalae 10-20 part, Rhizoma Paridis 8-15 part, Herba Hedyotidis Diffusae 10-20 part, Herba Scutellariae Barbatae 10-20 part, polygoni cuspidati,radix 8-15 part, Herba Violae 5-10 part, Spica Prunellae 10-20 part, Herba Duchesneae Indicae 10-20 part, xanthorrhiza 8-15 part, Caulis Lonicerae 10-20 part, Radix Tinosporae 8-15 part, Radix Notoginseng 5-10 part, Ramulus Mori 8-15 part, Fructus Chaenomelis 5-10 part, Lignum Sappan 5-10 part.
As the preferred embodiment of one, the raw material comprising following weight portion is made: Herba Elephantopi scaberis 25 parts, Herba Thesii Longifolii 15 parts, chamomile 15 parts, Herba Asari 8 parts, Halloysitum Rubrum 3 parts, Radix Polygalae 15 parts, Rhizoma Paridis 10 parts, Herba Hedyotidis Diffusae 15 parts, Herba Scutellariae Barbatae 15 parts, polygoni cuspidati,radix 12 parts, Herba Violae 8 parts, Spica Prunellae 15 parts, Herba Duchesneae Indicae 15 parts, xanthorrhiza 12 parts, Caulis Lonicerae 15 parts, Radix Tinosporae 10 parts, Radix Notoginseng 7 parts, Ramulus Mori 12 parts, Fructus Chaenomelis 7 parts, Lignum Sappan 8 parts.
As the preferred embodiment of one, the dosage form of described external medicine composition is eye drop.
In Chinese medicine composition of the present invention, Herba Elephantopi scaberis: bitter in the mouth, property is pungent, is slightly cold; Return lung, spleen, Liver Channel; There is removing heat from blood, heat clearing away, dehumidifying, diuretic, effect of removing toxic substances; Cure mainly epistaxis, jaundice, gonorrhea, beriberi, edema, carbuncle, furuncle, snake bite and insect sting, heatstroke is generated heat, maculae caused by violent heat pathogen, bloody dysentery, wind syndrome of head, acute toothache and various diseases associated with inflammation.
In Chinese medicine composition of the present invention, Herba Thesii Longifolii: bitter in the mouth, property is pungent, micro-cool; Return lung, liver, spleen channel; There is heat clearing away of inducing sweat, the effect of expellingging wind and relieving convulsion; Cure mainly flu, heatstroke, infantile pneumonia, infantile convulsion.
In Chinese medicine composition of the present invention, chamomile: bitter in the mouth, property is sweet, micro-perfume (or spice); There is improving eyesight, move back liver-fire, Cure for insomnia, reduce blood pressure, memory reinforcing, the effect of invigorating and refreshing oneself; Emotion restless, the inflammation alleviating patient and pain symptom, help can be pacified fall asleep, treat constipation, alleviate headache, discongest eyestrain, eliminate anxiety, lung moistening, health preserving.
In Chinese medicine composition of the present invention, Herba Asari: acrid in the mouth, warm in nature; GUIXIN, lung, kidney channel; There is expelling wind and cold pain relieving, warming the lung to resolve fluid-retention, sensible effect; Cure mainly affection of exogenous wind-cold, headache, toothache, wind and cold temperature numbness, phlegm retention cough with asthma, nasal obstruction nasal sinusitis, wind-eye corneal nebula, deafness pharyngalgia, aphtha halitosis.
In Chinese medicine composition of the present invention, Halloysitum Rubrum: sweet in the mouth, puckery, property acid, tepor; Return spleen, stomach, the heart, large intestine channel; There is astringing intestine to stop diarrhea, astringing to arrest bleeding, removing dampness sore, effect of granulation promoting; Cure mainly chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, seminal emission, metrorrhagia, leukorrhagia, ulcer being unable to heal, eczema, traumatic hemorrhage.
In Chinese medicine composition of the present invention, Radix Polygalae: bitter in the mouth, property is pungent, tepor; GUIXIN, kidney, lung meridian; The effect of there is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling; Cure mainly that the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration are not well, sore swollen toxin, breast swell and pain.
In Chinese medicine composition of the present invention, Rhizoma Paridis: bitter in the mouth, cool in nature; GUIXIN, liver, lung, stomach, large intestine channel; There is effect of anticancer, the reducing swelling and alleviating pain of relieving internal heat, heat clearing away arresting convulsion, antitussive and antiasthmatic; Cure mainly the diseases such as carbuncle pulmonary tuberculosis chronic cough, traumatic injury, snake bite and insect sting, lymphoid tuberculosis, osteomyelitis.
In Chinese medicine composition of the present invention, Herba Hedyotidis Diffusae: bitter sweet, cold in nature; GUIXIN, liver, spleen channel; There is heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis, heat clearing away dissipating blood stasis, effect of clear infantile malnutrition; Cure mainly dyspnea and cough due to lung-heat, tonsillitis, pharyngolaryngitis, appendicitis, dysentery, jaundice, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom.
In Chinese medicine composition of the present invention, Herba Scutellariae Barbatae: bitter in the mouth, property is pungent, is slightly cold; Return lung, liver, kidney channel; Have heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, effect of inducing diuresis to remove edema; Cure mainly pyretic toxicity carbuncle, have sore throat, lung abscess, acute appendicitis, scrofula, venom, traumatic injury, spit blood, epistaxis, stranguria with blood, edema, ascites and cancer.
In Chinese medicine composition of the present invention, polygoni cuspidati,radix: bitter in the mouth, is slightly cold; Return liver, gallbladder, lung meridian; There is Huoxue San " expectorant, effect of dispel the wind removing toxic substances, anti-inflammatory analgetic; Can remuval of damp and hot jaundice, control chronic tracheitis, reduce blood fat; Cure mainly arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.
In Chinese medicine composition of the present invention, Herba Violae: bitter in the mouth, cold in nature; GUIXIN, spleen channel; There is effect of heat-clearing and toxic substances removing; Cure mainly the high heat of epidemic febrile disease irritated, influenza, infectious hepatitis, nephritis, scrofula, parotitis, furuncle and other pyogenic infection.
In Chinese medicine composition of the present invention, Spica Prunellae: bitter in the mouth, property is pungent, is slightly cold; Return liver, gallbladder meridian; There is the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis; Cure mainly lymphoid tuberculosis, goiter, acute mastitis, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, metrorrhagia, leukorrhagia, Fiedeler's disease type hepatitis and bacillary dysentery etc.
In Chinese medicine composition of the present invention, Herba Duchesneae Indicae: bitter in the mouth; Cool in nature; Return liver, kidney, large intestine channel; There is heat-clearing and toxic substances removing; Effect of dissipating blood stasis for subsidence of swelling; Cure mainly upper respiratory tract infection, oral ulcer, pneumonia, mastitis, enteritis, bacillary dysentery, urinary tract infection, furuncle carbuncle, eczema, traumatic injury.
In Chinese medicine composition of the present invention, xanthorrhiza: bitter in the mouth is micro-cool; There is cooling blood for hemostasis, dampness removing jaundice eliminating, effect of the strong muscle of dissipating blood stasis; Cure mainly gingival hemorrhage, anemia, hepatitis, rheumatic arthritis, traumatic injury, urinary tract infection.
In Chinese medicine composition of the present invention, Caulis Lonicerae: sweet in the mouth, cold in nature; Attach to the lung and stomach meridians; There is heat-clearing and toxic substances removing, effect of dispelling wind dredging collateral; Cure mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, redness and swelling of joints burning pain.
In Chinese medicine composition of the present invention, Radix Tinosporae: bitter in the mouth, cold in nature; Return lung, large intestine channel; There is heat-clearing and toxic substances removing, sore-throat relieving, effect of reducing swelling and alleviating pain; Cure mainly laryngopharynx swelling and pain, carbuncle furunculosis, has loose bowels, dysentery, gastral cavity abdomen burning pain.
In Chinese medicine composition of the present invention, Radix Notoginseng: sweet in the mouth, micro-hardship, warm in nature; Return liver, stomach warp; There is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain; Cure mainly spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.
In Chinese medicine composition of the present invention, Ramulus Mori: bitter in the mouth, property is put down; Return lung, kidney channel; There is wind-damp dispelling, sharp joint, effect of row aqueous vapor; Cure mainly anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen.
In Chinese medicine composition of the present invention, Fructus Chaenomelis: sweet in the mouth, property is put down, and is slightly cold; Return liver, spleen channel; Have aid digestion, nourishing the lung to arrest cough, suppressing the hyperactive liver relaxing muscles and tendons, effect of stomach function regulating removing dampness; Cure mainly arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.
In Chinese medicine composition of the present invention, Lignum Sappan: sweet in the mouth, property is pungent, micro-cool; GUIXIN, liver, stomach, spleen channel; There is blood circulation promoting and blood stasis dispelling, effect of subduing swelling and relieving pain; Cure mainly married woman's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stagnation cardiac and abdominal pain, puerperal blood faints, carbuncle, traumatic injury, tetanus.
Usage of the present invention and consumption: eye drop of the present invention, every eyes drip 1-3 at every turn and drip, and are equivalent to the 1-3g of crude drug amount, every day 3-5 time, and within 1 week, be 1 course for the treatment of, 1-3 the course for the treatment of can cure.
The invention has the beneficial effects as follows: the present invention's each taste herbal raw material scientific compatibility, drug effect complements each other, bring out the best in each other, impose on collaterals of human, through focus depths, with clearing away heat and cooling blood, removing toxic substances diuretic, detumescence dissipating blood stasis for guiding principle, to let out clearly liver-fire, Fructus Alpiniae Oxyphyllae of calming the nerves for order, reach effect of improving acuity of vision and removing nebula, effective ingredient absorbs fast, effectively can eliminate keratopathy, essence treatment is carried out to viral keratitis; C 3 b receptor of red blood cells rosette rate can also be improved, strengthen the body's immunity of patient, prevent recurrence.This Chinese medicine composition external application uses, and application is convenient, short treating period, good effect, and cure rate is high, treating both the principal and secondary aspects of a disease; Its raw material is all selected from natural herbal raw material, prepare easy, medicine source is wide, cost is low, mild in medicine property and, skin adaptability is good, can not cause secondary injury, have no side effect to eyes, greatly reduces economy and the psychological burden of patient.
Detailed description of the invention
Be clearly and completely described technical scheme of the present invention below in conjunction with specific embodiments of the invention, obviously, described embodiment is only a part of embodiment of the present invention, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Treat an external medicine composition for viral keratitis, the raw material comprising following weight portion is made: Herba Elephantopi scaberis 20-30 part, Herba Thesii Longifolii 10-20 part, chamomile 10-20 part, Herba Asari 5-10 part, Halloysitum Rubrum 1-5 part, Radix Polygalae 10-20 part, Rhizoma Paridis 8-15 part, Herba Hedyotidis Diffusae 10-20 part, Herba Scutellariae Barbatae 10-20 part, polygoni cuspidati,radix 8-15 part, Herba Violae 5-10 part, Spica Prunellae 10-20 part, Herba Duchesneae Indicae 10-20 part, xanthorrhiza 8-15 part, Caulis Lonicerae 10-20 part, Radix Tinosporae 8-15 part, Radix Notoginseng 5-10 part, Ramulus Mori 8-15 part, Fructus Chaenomelis 5-10 part, Lignum Sappan 5-10 part.
Preferably, the raw material comprising following weight portion is made: Herba Elephantopi scaberis 25 parts, Herba Thesii Longifolii 15 parts, chamomile 15 parts, Herba Asari 8 parts, Halloysitum Rubrum 3 parts, Radix Polygalae 15 parts, Rhizoma Paridis 10 parts, Herba Hedyotidis Diffusae 15 parts, Herba Scutellariae Barbatae 15 parts, polygoni cuspidati,radix 12 parts, Herba Violae 8 parts, Spica Prunellae 15 parts, Herba Duchesneae Indicae 15 parts, xanthorrhiza 12 parts, Caulis Lonicerae 15 parts, Radix Tinosporae 10 parts, Radix Notoginseng 7 parts, Ramulus Mori 12 parts, Fructus Chaenomelis 7 parts, Lignum Sappan 8 parts.
Particularly, the dosage form of described external medicine composition is eye drop.
embodiment one
A kind of external medicine composition for the treatment of viral keratitis of the present invention, the raw material comprising following weight portion is made: Herba Elephantopi scaberis 20 parts, Herba Thesii Longifolii 10 parts, chamomile 10 parts, Herba Asari 5 parts, Halloysitum Rubrum 1 part, Radix Polygalae 10 parts, Rhizoma Paridis 8 parts, Herba Hedyotidis Diffusae 10 parts, Herba Scutellariae Barbatae 10 parts, polygoni cuspidati,radix 8 parts, Herba Violae 5 parts, Spica Prunellae 10 parts, Herba Duchesneae Indicae 10 parts, xanthorrhiza 8 parts, Caulis Lonicerae 10 parts, Radix Tinosporae 8 parts, Radix Notoginseng 5 parts, Ramulus Mori 8 parts, Fructus Chaenomelis 5 parts, Lignum Sappan 5 parts.
Get above-mentioned raw materials, pulverize, mixing, adds water, and extracts, and sterilization, makes eye drop, and the external application of gained Chinese medicine composition uses, and directly drops to eyes.
embodiment two
A kind of external medicine composition for the treatment of viral keratitis of the present invention, the raw material comprising following weight portion is made: Herba Elephantopi scaberis 25 parts, Herba Thesii Longifolii 15 parts, chamomile 15 parts, Herba Asari 8 parts, Halloysitum Rubrum 3 parts, Radix Polygalae 15 parts, Rhizoma Paridis 10 parts, Herba Hedyotidis Diffusae 15 parts, Herba Scutellariae Barbatae 15 parts, polygoni cuspidati,radix 12 parts, Herba Violae 8 parts, Spica Prunellae 15 parts, Herba Duchesneae Indicae 15 parts, xanthorrhiza 12 parts, Caulis Lonicerae 15 parts, Radix Tinosporae 10 parts, Radix Notoginseng 7 parts, Ramulus Mori 12 parts, Fructus Chaenomelis 7 parts, Lignum Sappan 8 parts.
Get above-mentioned raw materials, pulverize, mixing, adds water, and extracts, and sterilization, makes eye drop, and the external application of gained Chinese medicine composition uses, and directly drops to eyes.
embodiment three
A kind of external medicine composition for the treatment of viral keratitis of the present invention, the raw material comprising following weight portion is made: Herba Elephantopi scaberis 30 parts, Herba Thesii Longifolii 20 parts, chamomile 20 parts, Herba Asari 10 parts, Halloysitum Rubrum 5 parts, Radix Polygalae 20 parts, Rhizoma Paridis 15 parts, Herba Hedyotidis Diffusae 20 parts, Herba Scutellariae Barbatae 20 parts, polygoni cuspidati,radix 15 parts, Herba Violae 10 parts, Spica Prunellae 20 parts, Herba Duchesneae Indicae 20 parts, xanthorrhiza 15 parts, Caulis Lonicerae 20 parts, Radix Tinosporae 15 parts, Radix Notoginseng 10 parts, Ramulus Mori 15 parts, Fructus Chaenomelis 10 parts, Lignum Sappan 10 parts.
Get above-mentioned raw materials, pulverize, mixing, adds water, and extracts, and sterilization, makes eye drop, and the external application of gained Chinese medicine composition uses, and directly drops to eyes.
Set forth the present invention further below in conjunction with concrete test example, wherein, comprise the animal toxicity test of Chinese medicine composition of the present invention, pharmacodynamics test and clinical observation test.
animal toxicity test
Acute toxicity test: get the healthy rabbit 20 without ophthalmic, male and female half and half, body weight 1.8-2.3kg, is divided into two groups, often organizes 10; Two groups of rabbit administrations are given according to 200 times and 350 times of clinical consumption per day respectively by Chinese medicine composition of the present invention, in experiment, every homogeneous branch hole of rabbit drips the medicinal liquid of a Chinese medicine composition of the present invention, another branch hole is contrast (namely not dripping any medicinal liquid), every day 3 times, continuous use 1 week, observes administration reaction every day; Experimental result shows: in the observation period, two treated animals are all without the phenomena of mortality, and in two groups of rabbit, redness, congested phenomenon all do not appear in the eyes dripping medicinal liquid, have no irritative response and other untoward reaction; Observe one week again after drug withdrawal, also do not occur red and swollen and congested phenomenon, have no irritative response and other untoward reaction.Therefore, Chinese medicine composition of the present invention is to after Rabbits with Acute medication, non-stimulated to skin, nontoxic to experimenter, can not cause secondary injury, application safety to eyes.
Long term toxicity test: separately get the healthy rabbit 20 without ophthalmic, male and female half and half, body weight 1.8-2.3kg, is divided into two groups, often organizes 10; Two groups of rabbit administrations are given according to 50 times of clinical consumption per day respectively by Chinese medicine composition of the present invention, in experiment, every homogeneous branch hole of rabbit drips the medicinal liquid of a Chinese medicine composition of the present invention, another branch hole is contrast (namely not dripping any medicinal liquid), every day 3 times, continuous use 16 weeks drug withdrawal 4 weeks, observe administration every day and react; Experimental result shows: in the observation period, two treated animals are all without the phenomena of mortality, and in two groups of rabbit, redness, congested phenomenon all do not appear in the eyes dripping medicinal liquid, have no irritative response and other untoward reaction; Observe 4 weeks again after drug withdrawal, also do not occur red and swollen and congested phenomenon, have no irritative response and other untoward reaction.Therefore, Chinese medicine composition of the present invention is to after rabbit long-term prescription, non-stimulated to skin, nontoxic to experimenter, can not cause secondary injury, application safety to eyes.
animal pharmacodynamics test
1, the foundation of animal model
Get healthy cleaning grade female mice 60, Mus is 3-5 week age, body weight 17-23g, is divided into 6 groups at random, is respectively sham operated rats, model group, the experimental group of three kinds of Chinese medicine compositions composition of embodiment one to embodiment three and the eye drop matched group of certain commercially available treatment viral keratitis.Animal House temperature is 20.0 ± 3.0 DEG C, natural lighting, and feed, with sterilized commercial pellet diet, drinks the tap water of disinfecting, and animal freely ingests drinking-water, each group mice at experimental session by group sub-cage rearing.
After mice conforms 1 week, except sham operated rats, give every mice double ocellus 0.25% chloromycetin eyedrops, every day 2 times simultaneously.Second week starts after experiment mice chloral hydrate 0.06mL intraperitoneal injection of anesthesia, under being placed in microscope, intersecting and scratches cornea of right eye epithelial layer, 5 μ L are contained 1 × 10 with No. 25 aseptic operation blades 7the aseptic minimum basis basal culture medium (MEM) of PFUHSV-I virus is put in cornea of right eye surface and massages rathole eyelid 30s gently.Give mouse cornea fluorescein sodium before and after modeling respectively dye and use examination with slitlamp microscope cornea to change.After mouse cornea infects virus, 18h fluorescein sodium dyes, and checks that cornea changes under slit lamp microscope.Find that former corneal infection shows as acute epitheliated type keratitis, there is point-like, lamellar epithelial defect in mouse cornea, fluorescein sodium stained positive, herpes simplex keratitis mice modeling success.
2, administration
Mice 50 after modeling success, the 2nd day after modeling starts administration, sham operated rats and model group drip the distilled water of identical number, matched group is according to the consumption administration of the eye drop of commercially available treatment viral keratitis, experimental group drips the Chinese medicine composition of 1 embodiment of the present invention one to embodiment three respectively, the passive closed 3-5s of eyes is made, every day 3 times, successive administration 3 weeks after administration.
3, the mensuration expressed of the observation of mice situation and erythrocyte C3breceptor activity
Eyes dyeing is dripped with 2% fluorescein sodium normal saline solution after mouse cornea inoculation HSV-I, eye closing 1min, slit lamp microexamination keratopathy, after medication the 7th, 14,21 day, eyes dyeing is dripped with 2% fluorescein sodium normal saline solution, eye closing 1min, slit lamp microexamination keratopathy, corneal epithelium point-like, dendroid, map shape is painted and substrate is muddy.
Lesion degree criterion: with 0 to 4 score: 0 point: non-coloring and muddiness; 1 point: painted and muddy scope is within 1/4 of cornea area; 2 points: painted and muddy scope is between the 1/4-1/2 of cornea area; 3 points: painted and muddy scope is between the 1/2-3/4 of cornea area; 4 points: painted and muddy scope is more than 3/4 of cornea area.
After last administration 12h, by the intraperitoneal anesthesia of mice chloral hydrate, eyeball is put into 10% formalin and is fixed, and routine paraffin wax embeds.Pluck eyeball and get blood, blood puts into anticoagulant test tube, centrifugal remove supernatant after, cryogenic refrigerator preserve, carry out the experiment of C 3 b receptor of red blood cells rosette rate.
4, data analysis
Carry out statistical disposition with SPSSforWindows10.0 version software, measurement data adopts t inspection, and enumeration data adopts x 2inspection, result of the test is as shown in table 1.
The impact of the scorching model mice of table 1 Chinese medicine composition corneal of the present invention
Remarks: compared with model group, *---P<0.05, * *---P<0.01.
As can be seen from Table 1, compared with model group, three kinds of Chinese medicine compositions of the embodiment of the present invention one to embodiment three gained and the eye drop (matched group in table 1) of commercially available treatment viral keratitis all can make keratopathy degree alleviate in keratopathy, and alleviate gradually along with the prolongation keratopathy degree of administration time; But, compared with the eye drop of commercially available treatment viral keratitis, three kinds of Chinese medicine compositions of the embodiment of the present invention one to embodiment three gained can alleviate keratopathy degree to a greater degree, and alleviate keratopathy degree to a greater degree along with the prolongation of administration time; This demonstrate that Chinese medicine composition of the present invention better can improve keratopathy.Simultaneously, erythrocyte can not only stick and operate harmful immune complex, and energy concentrated antigen, antigen is passed to T lymphocyte, the immunoreation of enhancing and activated T lymphocytes, the C 3 b receptor of red blood cells rosette rate of model group mice significantly reduces, and three kinds of Chinese medicine compositions of the embodiment of the present invention one to embodiment three gained and the eye drop of commercially available treatment viral keratitis all can improve the C 3 b receptor of red blood cells rosette rate of Keratitis Model mice; Compared with the eye drop of certain commercially available treatment viral keratitis, three kinds of Chinese medicine compositions of the embodiment of the present invention one to embodiment three gained can improve the C 3 b receptor of red blood cells rosette rate of Keratitis Model mice to a greater degree.
Therefore, Chinese medicine composition of the present invention has better curative effect compared with the treatment of the eye drop corneal inflammation of certain commercially available treatment viral keratitis.
clinical observation is tested
Patient data
Random selecting 20-55 year viral keratitis patient 200 example, wherein, man 110 example, female 90 example, the course of disease is 5 days to 2 years, first attack 80 example, recurrence 120 example; Two groups are divided into according to the method for M-F, ratio of age and course of disease balanced proportion, be respectively a matched group and a treatment group, often organize each 100 examples, do not have diversity statistically between two groups of patients, two groups of patients all meet the diagnostic criteria of viral keratitis; These two groups of patients are before accepting this treatment, and all once with the Therapeutic Method such as Western medicine or Chinese medicine, but effect is not remarkable, easily recurs, can not dig up the roots.
Diagnostic criteria
Determine with reference to " eye, OtorhinolaryngologicDiseases Diseases diagnostic criteria " and " Chinese medical disease Standardization of diagnosis and curative effect ", " clinical disease diagnosis and curative effect judging standard " determined diagnostic criteria: 1, with on the skin of ophthalmic branch of trigeminal nerve areal area occur herpes and deposit or occupy its sequela, skin lesion does not surmount center line; Or have whole body heating, preauricular lymph nodes enlargement, the viral infection such as lip or skin bleb medical history.2, corneal lesion, can involve epithelium, substrate or form ulcer; Cornea fluorescence staining is to circular spot or dendroid sign; Can with ocular pain, photophobia, shed tears, conjunctival congestion or merge scleritis, iridocyclitis.
Exclusion standard
1, gestation, women breast-feeding their children; 2, allergies person is had; 3, the severe primary diseases such as cardiovascular, liver, kidney and hemopoietic system are associated with, psychotic; 4, the non-viral keratitis caused; 5, the patient of other ocular disease medical histories is associated with; 6, generate heat: body temperature is higher than 38.5 DEG C; 7, allly do not meet inclusive criteria, not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment and safety judgement person.
Therapeutic scheme
Matched group: patient drips the eye drop of certain commercially available treatment viral keratitis deposited respectively, every day 8 times, every eye 2,15 days are 1 course for the treatment of at every turn, use 3 courses for the treatment of continuously;
Treatment group: patient is the Chinese medicine composition prepared of external application the present invention respectively, every day 3 times, every eye 2,1 week are 1 course for the treatment of, use 3 courses for the treatment of continuously at every turn.
Have an eyesight test respectively after each course for the treatment of and slit lamp microscope fluorescence staining inspection local patholoic change situation, and use appropriate cards record, gather therapeutic outcome special messenger keeping after treatment, after all cases completes, carry out statistical procedures.Two groups all strictly control variable factor, do not add the medicine by other influences curative effect and method during treatment; Adopt mono blind method in experiment, total Test process meets moral demand.
Therapeutic effect
The criterion of therapeutical effect assert with reference to " the disease of tcm Standardization of diagnosis and curative effect " and " clinical disease diagnosis and curative effect judging standard " of State Administration of Traditional Chinese Medicine's issue determines following standard.
Cure: conjunctival congestion edema disappears, the multiple dendroid of corneal epithelium infiltrates and disappears, and keratoiridocyclitis disappears, and photophobia is shed tears transference cure, and corneal fluorescein dyeing is negative;
Take a turn for the better: the slight hyperemia of conjunctiva alleviates, the multiple dendroid of corneal epithelium infiltrates and alleviates, and keratoiridocyclitis alleviates, and photophobia symptom of shedding tears alleviates, a little weak positive of cornea fluorescence dyeing;
Invalid: conjunctiva is obviously congested, the multiple dendroid infiltration of corneal epithelium and keratoiridocyclitis are without improvement, and corneal fluorescein stained positive, inflammation does not control or pathological changes increases the weight of.
Clinical observation result
Experimental result adopts SPSSforWindows10.0 version software to carry out statistical disposition, and measurement data adopts t inspection, and enumeration data adopts x 2inspection, clinical treatment outcome situation and curative effect time started, average course for the treatment of and treatment Patients Before And After vision situation of change are carried out respectively adding up and gathering, experimental result is listed in table 2 and table 3 respectively.
Table 2 clinical treatment outcome comparing result
Table 3 clinical treatment outcome comparing result
As can be seen from table 2 and table 3, compared with matched group, Chinese medicine composition of the present invention has better curative effect to viral keratitis treatment, and clearly, cure rate obviously raises advantage, reaches 79%, and all effectively, total effective rate is 100%; Mild in medicine property and, skin adapts to, and can not cause secondary injury to eyes, significantly reduces the misery of patient; Through focus depths, effective ingredient absorbs fast, and namely occurred curative effect about about 2 days greatly, stable curative effect, average course for the treatment of only has 11.78 days, has no side effect, treating both the principal and secondary aspects of a disease, and after treatment, the vision of patient significantly rises.
Model case
Case 1: high certain, man, 27 years old, left eye is dry and astringent, photophobia, shed tears, pain, foreign body sensation, blurred vision 15 days, vision left eye 0.8, right eye 1.5, conjunctiva of left eye mild hyperaemia, the visible intensive point-like defect of corneal epithelium; Examine as viral keratitis; Within first 10 days, drip and applied Beifushu eyedrop eye drip, have no positive effect; Use the eye drop that Chinese medicine composition of the present invention is made, every day 3 times, every eyes 1-3 drips at every turn; Use 2 days, dry and astringent, symptom of shedding tears obviously alleviates; Use after 5 days, pain, foreign body sensation and photophobia symptom are clearly better; After using 1 course for the treatment of, eye symptom all disappears; On inspection, vision left eye 1.2, right eye 1.5, cornea of left eye is negative staining, reaches the therapeutic effect of clinical cure; Follow up a case by regular visits in 1 year and do not recur.
Case 2: Lee, female, 39 years old, the dry and astringent photophobia of right eye, twinge were shed tears, vision declines gradually, repeatedly nearly 2 years of protracted course of disease; Ganciclovir eye drop eye is crossed in once external application, has no positive effect, also the Chinese medicine decoction of once orally taken for curing viral keratitis, and this flavour of a drug road is pained, and be difficult to swallow, the course for the treatment of is long, takes effect slowly, easily recurs, greatly have impact on the mood of patient after drug withdrawal.Check: vision right eye 0.2, left eye 0.8, the mixed congestion of right eye bulbar conjunctiva is obvious, and cornea nasal side is that dendroid is muddy, and fluorescent staining is positive, and left eye is without exception; Diagnosis: right eye herpes simplex keratitis.The eye drop that recent use Chinese medicine composition of the present invention is made, every day 4 times, every eyes 1-3 drips at every turn; Observe after 1 course for the treatment of, dry and astringent, twinge and photophobia are eased, and take a turn for the better gradually depending on thing; After continuing 1 course for the treatment of of use, above-mentioned symptom all disappears, on inspection, vision right eye 0.8, left eye 0.8, cornea of right eye is negative staining, and immunity of organisms increases, and reaches the therapeutic effect of clinical cure; Follow up a case by regular visits in 2 years and do not recur.
Case 3: field, man, 51 years old, right eye suffered from herpes simplex keratitis nearly 1 year, and dry and astringent photophobia, twinge are shed tears and seen the herpes of grain of rice size, blurred vision, bad during fashion; Once the Western medicine of external application for curing viral keratitis, had no positive effect; Also once used the Chinese traditional medicine lotion for the treatment of viral keratitis, Chinese traditional medicine lotion uses inconvenient, obstinate, recurrent exerbation; On inspection, right eye mixed congestion, respectively there is the herpes of a grain of rice size at 5 points around cornea, 9 places, vision left eye 1.1, right eye 0.2; The eye drop that recent use Chinese medicine composition of the present invention is made, every day 5 times, every eyes 1-3 drips at every turn; Observe after 1 course for the treatment of, herpes and twinge symptom are eased, and take a turn for the better depending on thing symptom; After continuing 1 course for the treatment of of use, pain symptom obviously alleviates, one's eyes drop millstones; After continuing 1 course for the treatment of of use, above-mentioned symptom all disappears, on inspection, vision left eye 1.1, right eye 1.0, cornea of right eye is negative staining, reaches the therapeutic effect of clinical cure; Follow up a case by regular visits in 3 years and do not recur.
The invention has the beneficial effects as follows: the present invention's each taste herbal raw material scientific compatibility, drug effect complements each other, bring out the best in each other, impose on collaterals of human, through focus depths, with clearing away heat and cooling blood, removing toxic substances diuretic, detumescence dissipating blood stasis for guiding principle, to let out clearly liver-fire, Fructus Alpiniae Oxyphyllae of calming the nerves for order, reach effect of improving acuity of vision and removing nebula, effective ingredient absorbs fast, effectively can eliminate keratopathy, essence treatment is carried out to viral keratitis; C 3 b receptor of red blood cells rosette rate can also be improved, strengthen the body's immunity of patient, prevent recurrence.This Chinese medicine composition external application uses, and application is convenient, short treating period, good effect, and cure rate is high, treating both the principal and secondary aspects of a disease; Its raw material is all selected from natural herbal raw material, prepare easy, medicine source is wide, cost is low, mild in medicine property and, skin adaptability is good, can not cause secondary injury, have no side effect to eyes, greatly reduces economy and the psychological burden of patient.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (3)

1. treat an external medicine composition for viral keratitis, it is characterized in that, the raw material comprising following weight portion is made:
Herba Elephantopi scaberis 20-30 part, Herba Thesii Longifolii 10-20 part, chamomile 10-20 part, Herba Asari 5-10 part, Halloysitum Rubrum 1-5 part, Radix Polygalae 10-20 part, Rhizoma Paridis 8-15 part, Herba Hedyotidis Diffusae 10-20 part, Herba Scutellariae Barbatae 10-20 part, polygoni cuspidati,radix 8-15 part, Herba Violae 5-10 part, Spica Prunellae 10-20 part, Herba Duchesneae Indicae 10-20 part, xanthorrhiza 8-15 part, Caulis Lonicerae 10-20 part, Radix Tinosporae 8-15 part, Radix Notoginseng 5-10 part, Ramulus Mori 8-15 part, Fructus Chaenomelis 5-10 part, Lignum Sappan 5-10 part.
2. the external medicine composition for the treatment of viral keratitis according to claim 1, is characterized in that, the raw material comprising following weight portion is made:
Herba Elephantopi scaberis 25 parts, Herba Thesii Longifolii 15 parts, chamomile 15 parts, Herba Asari 8 parts, Halloysitum Rubrum 3 parts, Radix Polygalae 15 parts, Rhizoma Paridis 10 parts, Herba Hedyotidis Diffusae 15 parts, Herba Scutellariae Barbatae 15 parts, polygoni cuspidati,radix 12 parts, Herba Violae 8 parts, Spica Prunellae 15 parts, Herba Duchesneae Indicae 15 parts, xanthorrhiza 12 parts, Caulis Lonicerae 15 parts, Radix Tinosporae 10 parts, Radix Notoginseng 7 parts, Ramulus Mori 12 parts, Fructus Chaenomelis 7 parts, Lignum Sappan 8 parts.
3. the external medicine composition for the treatment of viral keratitis according to claim 1 and 2, is characterized in that:
The dosage form of described external medicine composition is eye drop.
CN201510959912.6A 2015-12-21 2015-12-21 Externally applied traditional Chinese medicine composition used for treating viral keratitis Pending CN105395718A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI749568B (en) * 2019-06-04 2021-12-11 旭龍生醫電子股份有限公司 Ophthalmic compositions and medical uses thereof in treatment of myopia

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103800485A (en) * 2014-03-12 2014-05-21 马丽 Traditional Chinese medicine preparation for treating herpes simplex keratitis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103800485A (en) * 2014-03-12 2014-05-21 马丽 Traditional Chinese medicine preparation for treating herpes simplex keratitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI749568B (en) * 2019-06-04 2021-12-11 旭龍生醫電子股份有限公司 Ophthalmic compositions and medical uses thereof in treatment of myopia

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Application publication date: 20160316